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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zfp423

Z-value: 0.44

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Transcription factors associated with Zfp423

Gene Symbol Gene ID Gene Info
Zfp423
ENSMUSG00000045333.9 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87959560_879595950.261.2e-01Click!

Activity profile of Zfp423 motif

Sorted Z-values of Zfp423 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_86628174 1.96 ENSMUST00000043400.6
Asprv1
aspartic peptidase, retroviral-like 1
chr12_+_109459843 1.35 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr17_-_23645264 1.01 ENSMUST00000024696.7
Mmp25
matrix metallopeptidase 25
chr15_+_101293196 0.92 ENSMUST00000071328.6
6030408B16Rik
RIKEN cDNA 6030408B16 gene
chr19_+_7268296 0.88 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chrX_+_7822289 0.87 ENSMUST00000009875.4
Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chrX_-_75130844 0.81 ENSMUST00000114092.1
ENSMUST00000132501.1
ENSMUST00000153318.1
ENSMUST00000155742.1
Mpp1
membrane protein, palmitoylated
chr10_+_3973086 0.64 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr4_+_154237525 0.60 ENSMUST00000152159.1
Megf6
multiple EGF-like-domains 6
chrX_-_75130996 0.58 ENSMUST00000033775.2
Mpp1
membrane protein, palmitoylated
chr9_-_37552904 0.57 ENSMUST00000065668.5
Nrgn
neurogranin
chr10_+_60349318 0.57 ENSMUST00000105459.1
4632428N05Rik
RIKEN cDNA 4632428N05 gene
chrX_-_75130914 0.52 ENSMUST00000114091.1
Mpp1
membrane protein, palmitoylated
chr15_+_78244781 0.47 ENSMUST00000096357.5
ENSMUST00000133618.1
Ncf4
neutrophil cytosolic factor 4
chr7_+_29307924 0.46 ENSMUST00000108230.1
ENSMUST00000065181.5
Dpf1
D4, zinc and double PHD fingers family 1
chr7_+_30421724 0.44 ENSMUST00000108176.1
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr5_-_22344690 0.43 ENSMUST00000062372.7
ENSMUST00000161356.1
Reln
reelin
chr11_-_106160101 0.42 ENSMUST00000045923.3
Limd2
LIM domain containing 2
chr4_-_106464167 0.41 ENSMUST00000049507.5
Pcsk9
proprotein convertase subtilisin/kexin type 9
chr11_-_94474088 0.37 ENSMUST00000107786.1
ENSMUST00000107791.1
ENSMUST00000103166.2
ENSMUST00000107792.1
ENSMUST00000100561.3
ENSMUST00000107793.1
ENSMUST00000107788.1
ENSMUST00000107790.1
ENSMUST00000107789.1
ENSMUST00000107785.1
ENSMUST00000021234.8
Cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr17_+_55986494 0.36 ENSMUST00000011733.8
Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr7_-_141443314 0.34 ENSMUST00000106005.2
Lrdd
leucine-rich and death domain containing
chr16_+_17489639 0.33 ENSMUST00000023448.6
Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chr17_-_36867187 0.33 ENSMUST00000025329.6
ENSMUST00000174195.1
Trim15
tripartite motif-containing 15
chr17_-_32166879 0.33 ENSMUST00000087723.3
Notch3
notch 3
chr4_+_150914562 0.30 ENSMUST00000135169.1
Tnfrsf9
tumor necrosis factor receptor superfamily, member 9
chr2_+_164785994 0.28 ENSMUST00000152471.1
Snx21
sorting nexin family member 21
chr8_-_83699095 0.28 ENSMUST00000005616.8
Pkn1
protein kinase N1
chr2_+_13573927 0.28 ENSMUST00000141365.1
ENSMUST00000028062.2
Vim
vimentin
chr17_-_35074485 0.27 ENSMUST00000007259.3
Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr11_+_54902917 0.26 ENSMUST00000149324.1
Gpx3
glutathione peroxidase 3
chr2_+_106693185 0.25 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr19_-_10869757 0.23 ENSMUST00000120524.1
ENSMUST00000025645.7
Tmem132a
transmembrane protein 132A
chr1_-_51941261 0.22 ENSMUST00000097103.3
Gm8420
predicted gene 8420
chr17_-_29347902 0.22 ENSMUST00000095427.4
ENSMUST00000118366.1
Mtch1
mitochondrial carrier homolog 1 (C. elegans)
chr2_+_164785823 0.21 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
Snx21
sorting nexin family member 21
chr11_+_82101836 0.20 ENSMUST00000000194.3
Ccl12
chemokine (C-C motif) ligand 12
chr7_+_127485221 0.20 ENSMUST00000048896.6
Fbrs
fibrosin
chr17_-_10840285 0.18 ENSMUST00000041463.6
Pacrg
PARK2 co-regulated
chr4_+_42917234 0.18 ENSMUST00000107976.2
ENSMUST00000069184.2
N28178
expressed sequence N28178
chr15_+_101174096 0.18 ENSMUST00000000544.9
Acvr1b
activin A receptor, type 1B
chr2_+_180499893 0.17 ENSMUST00000029084.2
Ntsr1
neurotensin receptor 1
chr15_-_98777261 0.16 ENSMUST00000166022.1
Wnt10b
wingless related MMTV integration site 10b
chr4_-_117125618 0.16 ENSMUST00000183310.1
Btbd19
BTB (POZ) domain containing 19
chr7_-_5014645 0.15 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr19_+_10041548 0.15 ENSMUST00000115995.2
Fads3
fatty acid desaturase 3
chr7_-_105633525 0.15 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
Trim3
tripartite motif-containing 3
chr11_+_54902743 0.15 ENSMUST00000082430.3
Gpx3
glutathione peroxidase 3
chr12_+_102948843 0.14 ENSMUST00000101099.5
Unc79
unc-79 homolog (C. elegans)
chr7_-_45694369 0.14 ENSMUST00000040636.6
Sec1
secretory blood group 1
chr19_+_6401675 0.13 ENSMUST00000113471.1
ENSMUST00000113469.2
Rasgrp2
RAS, guanyl releasing protein 2
chr7_+_64153835 0.13 ENSMUST00000085222.5
ENSMUST00000107525.1
Trpm1
transient receptor potential cation channel, subfamily M, member 1
chr7_-_19458494 0.13 ENSMUST00000085715.5
Mark4
MAP/microtubule affinity-regulating kinase 4
chr17_+_69156791 0.13 ENSMUST00000112680.1
ENSMUST00000080208.5
Epb4.1l3
erythrocyte protein band 4.1-like 3
chr2_-_29055051 0.13 ENSMUST00000113843.1
ENSMUST00000157048.2
1700101E01Rik
RIKEN cDNA 1700101E01 gene
chrX_+_101254528 0.13 ENSMUST00000062000.4
Foxo4
forkhead box O4
chr1_+_134289997 0.12 ENSMUST00000027730.4
Myog
myogenin
chr1_-_54926311 0.12 ENSMUST00000179030.1
ENSMUST00000044359.9
Ankrd44
ankyrin repeat domain 44
chr11_+_60469339 0.12 ENSMUST00000071880.2
ENSMUST00000081823.5
ENSMUST00000094135.2
Myo15
myosin XV
chr16_+_58408443 0.12 ENSMUST00000046663.7
Dcbld2
discoidin, CUB and LCCL domain containing 2
chr9_+_57130690 0.11 ENSMUST00000160147.1
ENSMUST00000161663.1
ENSMUST00000034836.9
ENSMUST00000161182.1
Man2c1
mannosidase, alpha, class 2C, member 1
chr2_-_29253001 0.11 ENSMUST00000071201.4
Ntng2
netrin G2
chr15_-_78718113 0.11 ENSMUST00000088592.4
Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr13_-_47106176 0.11 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek
DEK oncogene (DNA binding)
chr14_+_119138415 0.11 ENSMUST00000065904.3
Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr7_-_16286744 0.10 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9
coiled-coil domain containing 9
chr6_+_6863769 0.10 ENSMUST00000031768.6
Dlx6
distal-less homeobox 6
chr9_-_21127346 0.10 ENSMUST00000001036.10
Tyk2
tyrosine kinase 2
chrX_+_58030622 0.09 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr5_+_24423851 0.09 ENSMUST00000141966.1
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr15_-_66286224 0.09 ENSMUST00000070256.7
Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr5_+_31297551 0.08 ENSMUST00000072228.5
Gckr
glucokinase regulatory protein
chrX_+_58030999 0.07 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3
zinc finger protein of the cerebellum 3
chr5_+_24423805 0.05 ENSMUST00000153274.1
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr6_-_124756478 0.05 ENSMUST00000088357.5
Atn1
atrophin 1
chr11_-_33203588 0.04 ENSMUST00000037746.6
Tlx3
T cell leukemia, homeobox 3
chr11_+_11115784 0.04 ENSMUST00000056344.4
Vwc2
von Willebrand factor C domain containing 2
chr10_+_81136223 0.03 ENSMUST00000048128.8
Zbtb7a
zinc finger and BTB domain containing 7a
chr7_+_64153916 0.03 ENSMUST00000107527.2
Trpm1
transient receptor potential cation channel, subfamily M, member 1
chr8_+_27260327 0.03 ENSMUST00000033880.5
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr9_+_120492606 0.02 ENSMUST00000007139.4
Eif1b
eukaryotic translation initiation factor 1B
chr7_-_105744312 0.02 ENSMUST00000141116.1
Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr4_+_129513581 0.02 ENSMUST00000062356.6
Marcksl1
MARCKS-like 1
chr10_+_82954344 0.01 ENSMUST00000095396.3
Gm4799
predicted gene 4799
chr14_+_70553687 0.01 ENSMUST00000161069.1
Hr
hairless
chr7_-_133122615 0.00 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr11_-_76846968 0.00 ENSMUST00000021201.5
Cpd
carboxypeptidase D
chr10_-_14705459 0.00 ENSMUST00000149485.1
ENSMUST00000154132.1
Vta1
Vps20-associated 1 homolog (S. cerevisiae)
chr5_-_136565432 0.00 ENSMUST00000176172.1
Cux1
cut-like homeobox 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0060022 hard palate development(GO:0060022)
0.1 0.4 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.1 0.6 GO:0046654 10-formyltetrahydrofolate metabolic process(GO:0009256) tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.4 GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.1 0.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.2 GO:0051885 positive regulation of anagen(GO:0051885)
0.1 0.3 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.3 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.1 0.3 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.3 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 0.2 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.0 1.9 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.3 GO:0072104 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.0 1.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.4 GO:0033085 negative regulation of T cell differentiation in thymus(GO:0033085) positive regulation of thymocyte apoptotic process(GO:0070245) negative regulation of thymocyte aggregation(GO:2000399)
0.0 0.1 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.0 0.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.1 GO:0009750 response to fructose(GO:0009750)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.6 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.5 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:2001032 cell quiescence(GO:0044838) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.6 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.3 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.5 GO:0071565 nBAF complex(GO:0071565)
0.0 1.9 GO:0030863 cortical cytoskeleton(GO:0030863)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 0.6 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.8 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.4 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 2.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 1.0 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.3 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 1.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis