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GSE67402: E.coli regulatory changes under long-term starvation

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Results for PurR

Z-value: 3.14

Transcription factors associated with PurR

Gene Symbol Gene ID Gene Info
purR PurR transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
purR0.831.2e-07Click!

Activity profile of PurR motif

Sorted Z-values of PurR motif

Network of associatons between targets according to the STRING database.

Promoter Score Transcript Gene Gene Info
glyA 53.32 serine hydroxymethyltransferase
guaBA 43.34 IMP dehydrogenase
GMP synthetase
purHD 36.61 AICAR transformylase/IMP cyclohydrolase
phosphoribosylamine-glycine ligase
purC 35.55 phosphoribosylaminoimidazole-succinocarboxamide synthase
prs 34.31 ribose-phosphate diphosphokinase
carAB 33.62 carbamoyl phosphate synthetase, β chain
carbamoyl phosphate synthetase, α chain
purL 30.29 phosphoribosylformylglycinamide synthetase
gcvTHP 29.76 glycine cleavage system H protein
glycine decarboxylase
aminomethyltransferase
purEK 27.37 N5-carboxyaminoimidazole ribonucleotide synthetase
N5-carboxyaminoimidazole ribonucleotide mutase
purA 23.80 adenylosuccinate synthetase
cvpA-purF-ubiX 19.39 membrane protein required for colicin V production
amidophosphoribosyl transferase
3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein
hflD-purB 13.42 adenylosuccinate lyase
lysogenization regulator
speAB 9.58 agmatinase
arginine decarboxylase, biosynthetic
purMN 9.57 phosphoribosylglycinamide formyltransferase 1
phosphoribosylformylglycinamide cyclo-ligase
codBA 3.41 cytosine transporter
cytosine deaminase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
30.3 30.3 GO:0006188 IMP biosynthetic process(GO:0006188)
23.8 23.8 GO:0046040 IMP metabolic process(GO:0046040)
20.8 83.1 GO:0006544 glycine metabolic process(GO:0006544) glycine catabolic process(GO:0006546)
14.4 43.3 GO:0046039 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037) GTP metabolic process(GO:0046039) guanosine-containing compound biosynthetic process(GO:1901070)
11.4 34.3 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
8.8 53.0 GO:0006541 glutamine metabolic process(GO:0006541)
5.9 35.2 GO:0006164 purine nucleotide biosynthetic process(GO:0006164)
3.2 9.6 GO:0006527 arginine catabolic process(GO:0006527)
2.5 35.5 GO:0033013 tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014)
1.1 3.4 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) pyrimidine nucleobase transport(GO:0015855)
0.3 13.4 GO:0009408 response to heat(GO:0009408)
0.1 9.6 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 29.8 GO:1990204 oxidoreductase complex(GO:1990204)
1.1 13.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 283.9 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
26.8 107.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
19.9 99.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
6.9 34.3 GO:0042301 phosphate ion binding(GO:0042301)
5.0 29.8 GO:0031405 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) lipoic acid binding(GO:0031405)
4.5 13.4 GO:0016842 amidine-lyase activity(GO:0016842)
3.8 86.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
2.4 9.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.7 3.4 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
1.5 19.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)