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GSE67402: E.coli regulatory changes under long-term starvation

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Results for ArgR

Z-value: 0.97

Transcription factors associated with ArgR

Gene Symbol Gene ID Gene Info
argR ArgR transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
argR0.252.1e-01Click!

Activity profile of ArgR motif

Sorted Z-values of ArgR motif

Promoter Log-likelihood Transcript Gene Gene Info
artJ 6.23 L-arginine ABC transporter - periplasmic binding protein
argG 3.69 argininosuccinate synthase
argCBH 3.53 argininosuccinate lyase
acetylglutamate kinase
N-acetylglutamylphosphate reductase
argE 3.35 acetylornithine deacetylase
artPIQM 3.22 L-arginine ABC transporter - membrane subunit
L-arginine ABC transporter - ATP binding subunit
periplasmic binding protein ArtI
L-arginine ABC transporter - membrane subunit
carAB 3.06 carbamoyl phosphate synthetase, β chain
carbamoyl phosphate synthetase, α chain
gltBDF 2.81 glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
argA 2.14 N-acetylglutamate synthase
argI 1.86 ornithine carbamoyltransferase chain I
hisJQMP 1.82 lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit
histidine ABC transporter - periplasmic binding protein
argD 1.59 N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase
argR 0.90 ArgR transcriptional dual regulator
metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp 0.55 tRNAfMet2
ribosome maturation factor RimP
30S ribosomal subunit protein S15
polynucleotide phosphorylase
30S ribosome binding factor
protein chain initiation factor IF2
transcription termination/antitermination L factor
tRNA pseudouridine 55 synthase
metY 0.38 tRNAfMet2

Network of associatons between targets according to the STRING database.

First level regulatory network of ArgR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.3 GO:0090467 L-arginine import(GO:0043091) L-amino acid import(GO:0043092) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine import into cell(GO:1902765) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
1.4 15.2 GO:0009084 glutamine family amino acid biosynthetic process(GO:0009084)
0.3 0.9 GO:0042150 plasmid recombination(GO:0042150)
0.2 0.5 GO:0031119 pseudouridine synthesis(GO:0001522) tRNA pseudouridine synthesis(GO:0031119) RNA 3'-end processing(GO:0031123)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing(GO:0055052)
0.1 10.9 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)
0.1 3.1 GO:1902494 catalytic complex(GO:1902494)
0.0 0.5 GO:0015935 small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627)
0.0 7.2 GO:0005737 cytoplasm(GO:0005737)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0016842 amidine-lyase activity(GO:0016842)
1.1 3.4 GO:0050897 cobalt ion binding(GO:0050897)
1.1 3.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.8 11.1 GO:0016597 amino acid binding(GO:0016597)
0.6 1.9 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.5 2.8 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.4 2.1 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.2 0.5 GO:0004532 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.1 3.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.9 GO:0000975 regulatory region DNA binding(GO:0000975) regulatory region nucleic acid binding(GO:0001067) transcription regulatory region DNA binding(GO:0044212)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage