YDR133C	10.3058	REI1	YDR133C||S000002540|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YNR001W-A	9.11476	REI1	YNR001W-A||S000007625|Dubious open reading frame unlikely to encode a functional protein; identified by homology
YFR055W	8.58512	REI1	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C	8.56524	REI1	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YPL014W	5.60921	REI1	YPL014W||S000005935|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YGR249W	5.37277	REI1	YGR249W|MGA1|S000003481|Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YBR126C	5.27269	REI1	YBR126C|TPS1|S000000330|Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YOL086C	5.18248	REI1	YOL086C|ADH1|S000005446|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YGL179C	5.10105	REI1	YGL179C|TOS3|S000003147|Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YIL162W	4.9371	REI1	YIL162W|SUC2|S000001424|Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YOL085C	4.77327	REI1	YOL085C||S000005445|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YBR126W-A	4.62014	REI1	YBR126W-A||S000028600|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YHL021C	3.99625	REI1	YHL021C|AIM17|S000001013|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YPR160W	3.91361	REI1	YPR160W|GPH1|S000006364|Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YBR183W	3.85887	REI1	YBR183W|YPC1|S000000387|Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YKL096W-A	3.73552	REI1	YKL096W-A|CWP2|S000001956|Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YDR516C	3.52999	REI1	YDR516C|EMI2|S000002924|Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YER066C-A	3.47913	REI1	YER066C-A||S000002959|Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
YGR138C	3.45339	REI1	YGR138C|TPO2|S000003370|Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YHL003C	3.38395	REI1	YHL003C|LAG1|S000000995|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YBR182C-A	3.25206	REI1	YBR182C-A||S000028603|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YNL160W	3.23185	REI1	YNL160W|YGP1|S000005104|Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YOL154W	3.02352	REI1	YOL154W|ZPS1|S000005514|Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YGR192C	3.01975	REI1	YGR192C|TDH3|S000003424|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YGR254W	2.95917	REI1	YGR254W|ENO1|S000003486|Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YJL158C	2.95069	REI1	YJL158C|CIS3|S000003694|Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YNL028W	2.83084	REI1	YNL028W||S000004973|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL048C	2.75774	REI1	YJL048C|UBX6|S000003584|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YJR073C	2.74002	REI1	YJR073C|OPI3|S000003834|Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
YGR139W	2.70159	REI1	YGR139W||S000003371|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL015W-A	2.68822	REI1	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL015C	2.68154	REI1	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YBR092C	2.60591	REI1	YBR092C|PHO3|S000000296|Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YHR094C	2.54541	REI1	YHR094C|HXT1|S000001136|Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YER067W	2.53859	REI1	YER067W||S000000869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YDR044W	2.53711	REI1	YDR044W|HEM13|S000002451|Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YDR095C	2.50546	REI1	YDR095C||S000002502|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR258W	2.4931	REI1	YLR258W|GSY2|S000004248|Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YGR052W	2.4705	REI1	YGR052W|FMP48|S000003284|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGL253W	2.45478	REI1	YGL253W|HXK2|S000003222|Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YPR119W	2.44178	REI1	YPR119W|CLB2|S000006323|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDL205C	2.40713	REI1	YDL205C|HEM3|S000002364|Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YER066W	2.322	REI1	YER066W||S000000868|Putative protein of unknown function; YER066W is not an essential gene
YNR014W	2.25741	REI1	YNR014W||S000005297|Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YMR290C	2.23512	REI1	YMR290C|HAS1|S000004903|ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDR345C	2.22648	REI1	YDR345C|HXT3|S000002753|Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR033W	2.17871	REI1	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YFR015C	2.1762	REI1	YFR015C|GSY1|S000001911|Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YKL091C	2.13971	REI1	YKL091C||S000001574|Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YIL111W	2.13963	REI1	YIL111W|COX5B|S000001373|Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YGR108W	2.10972	REI1	YGR108W|CLB1|S000003340|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YML103C	2.06683	REI1	YML103C|NUP188|S000004571|Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YOR273C	1.99114	REI1	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YLR286C	1.96734	REI1	YLR286C|CTS1|S000004276|Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YER124C	1.96037	REI1	YER124C|DSE1|S000000926|Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YLR150W	1.95951	REI1	YLR150W|STM1|S000004140|Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YPR074C	1.95546	REI1	YPR074C|TKL1|S000006278|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YLR109W	1.94313	REI1	YLR109W|AHP1|S000004099|Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YNL178W	1.94065	REI1	YNL178W|RPS3|S000005122|Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YMR290W-A	1.93044	REI1	YMR290W-A||S000004904|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YJL153C	1.91498	REI1	YJL153C|INO1|S000003689|Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YER131W	1.85319	REI1	YER131W|RPS26B|S000000933|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YMR261C	1.83992	REI1	YMR261C|TPS3|S000004874|Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YNL300W	1.82559	REI1	YNL300W||S000005244|Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YDR517W	1.82511	REI1	YDR517W|GRH1|S000002925|Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YLR177W	1.81212	REI1	YLR177W||S000004167|Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
YDL055C	1.80284	REI1	YDL055C|PSA1|S000002213|GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YPL037C	1.75171	REI1	YPL037C|EGD1|S000005958|Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YGR234W	1.74565	REI1	YGR234W|YHB1|S000003466|Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YPR157W	1.73338	REI1	YPR157W||S000006361|Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR086C	1.72878	REI1	YGR086C|PIL1|S000003318|Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YJR094W-A	1.7094	REI1	YJR094W-A|RPL43B|S000003855|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YBR206W	1.69644	REI1	YBR206W||S000000410|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3
YGL202W	1.69015	REI1	YGL202W|ARO8|S000003170|Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YHR180W-A	1.67353	REI1	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YML052W	1.64803	REI1	YML052W|SUR7|S000004516|Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YDL023C	1.63089	REI1	YDL023C||S000002181|Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YBR158W	1.62626	REI1	YBR158W|AMN1|S000000362|Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YKL008C	1.62608	REI1	YKL008C|LAC1|S000001491|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YOL101C	1.61375	REI1	YOL101C|IZH4|S000005461|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YJL196C	1.5775	REI1	YJL196C|ELO1|S000003732|Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YEL001C	1.56598	REI1	YEL001C|IRC22|S000000727|Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YPR149W	1.5575	REI1	YPR149W|NCE102|S000006353|Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YMR266W	1.55161	REI1	YMR266W|RSN1|S000004879|Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YHR181W	1.54756	REI1	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YLR154C	1.53376	REI1	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YNL066W	1.52656	REI1	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YPR196W	1.52288	REI1	YPR196W||S000006400|Putative maltose activator
YMR297W	1.52273	REI1	YMR297W|PRC1|S000004912|Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YER001W	1.49347	REI1	YER001W|MNN1|S000000803|Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YER088C-A	1.48824	REI1	YER088C-A||S000028754|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR082C	1.48258	REI1	YMR082C||S000004687|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL012W	1.4793	REI1	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YLR257W	1.46915	REI1	YLR257W||S000004247|Putative protein of unknown function
YCR009C	1.42267	REI1	YCR009C|RVS161|S000000602|Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YDR541C	1.42109	REI1	YDR541C||S000002949|Putative dihydrokaempferol 4-reductase
YJR103W	1.41589	REI1	YJR103W|URA8|S000003864|Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YDL022W	1.4154	REI1	YDL022W|GPD1|S000002180|NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YMR262W	1.41066	REI1	YMR262W||S000004875|Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
YOR317W	1.40423	REI1	YOR317W|FAA1|S000005844|Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YEL056W	1.40405	REI1	YEL056W|HAT2|S000000782|Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YHR163W	1.37489	REI1	YHR163W|SOL3|S000001206|6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YDR185C	1.37127	REI1	YDR185C||S000002593|Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YDR344C	1.366	REI1	YDR344C||S000002752|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL033W	1.36524	REI1	YAL033W|POP5|S000000031|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YJR074W	1.36219	REI1	YJR074W|MOG1|S000003835|Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
YPL247C	1.35166	REI1	YPL247C||S000006168|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YGR279C	1.34212	REI1	YGR279C|SCW4|S000003511|Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YNL029C	1.34092	REI1	YNL029C|KTR5|S000004974|Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YBL044W	1.33967	REI1	YBL044W||S000000140|Putative protein of unknown function; YBL044W is not an essential protein
YKL182W	1.33397	REI1	YKL182W|FAS1|S000001665|Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YER130C	1.33384	REI1	YER130C||S000000932|Hypothetical protein
YKL090W	1.28999	REI1	YKL090W|CUE2|S000001573|Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YOR226C	1.25544	REI1	YOR226C|ISU2|S000005752|Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YDR309C	1.23183	REI1	YDR309C|GIC2|S000002717|Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YGL148W	1.22542	REI1	YGL148W|ARO2|S000003116|Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YIL051C	1.21491	REI1	YIL051C|MMF1|S000001313|Mitochondrial protein involved in maintenance of the mitochondrial genome
YHR162W	1.21305	REI1	YHR162W||S000001205|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YER083C	1.20885	REI1	YER083C|GET2|S000000885|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
YGL199C	1.2023	REI1	YGL199C||S000003167|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
YHR010W	1.20223	REI1	YHR010W|RPL27A|S000001052|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YBR085C-A	1.19777	REI1	YBR085C-A||S000007522|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YLR437C	1.19465	REI1	YLR437C||S000004429|Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YDR276C	1.1905	REI1	YDR276C|PMP3|S000002684|Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YGL225W	1.1879	REI1	YGL225W|VRG4|S000003193|Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YJR113C	1.18728	REI1	YJR113C|RSM7|S000003874|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YNL193W	1.17647	REI1	YNL193W||S000005137|Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
YPL263C	1.16997	REI1	YPL263C|KEL3|S000006184|Cytoplasmic protein of unknown function
YFR054C	1.16974	REI1	YFR054C||S000001950|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR094W	1.1637	REI1	YDR094W||S000002501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YLL050C	1.14377	REI1	YLL050C|COF1|S000003973|Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YJR102C	1.14314	REI1	YJR102C|VPS25|S000003863|Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YPL274W	1.14256	REI1	YPL274W|SAM3|S000006195|High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YDL022C-A	1.13995	REI1	YDL022C-A||S000028537|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YMR205C	1.13375	REI1	YMR205C|PFK2|S000004818|Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YKL128C	1.13208	REI1	YKL128C|PMU1|S000001611|Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YHL028W	1.12779	REI1	YHL028W|WSC4|S000001020|ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YGR127W	1.12774	REI1	YGR127W||S000003359|Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
YKR074W	1.12446	REI1	YKR074W|AIM29|S000001782|Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YHR190W	1.11949	REI1	YHR190W|ERG9|S000001233|Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
YPL087W	1.10483	REI1	YPL087W|YDC1|S000006008|Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity
YLR154W-B	1.1023	REI1	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YEL073C	1.09568	REI1	YEL073C||S000000799|Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline
YDR279W	1.08257	REI1	YDR279W|RNH202|S000002687|Ribonuclease H2 subunit, required for RNase H2 activity
YBR177C	1.07676	REI1	YBR177C|EHT1|S000000381|Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YDR074W	1.0741	REI1	YDR074W|TPS2|S000002481|Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YER177W	1.07203	REI1	YER177W|BMH1|S000000979|14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YOL155C	1.05993	REI1	YOL155C|HPF1|S000005515|Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YGR242W	1.0459	REI1	YGR242W||S000003474|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YGR107W	1.04379	REI1	YGR107W||S000003339|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR241C	1.03224	REI1	YGR241C|YAP1802|S000003473|Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YEL038W	1.03092	REI1	YEL038W|UTR4|S000000764|Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus
YDL125C	1.02495	REI1	YDL125C|HNT1|S000002283|Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YPR063C	1.01904	REI1	YPR063C||S000006267|ER-localized protein of unknown function
YAL038W	1.01714	REI1	YAL038W|CDC19|S000000036|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YHR141C	1.00494	REI1	YHR141C|RPL42B|S000001183|Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YMR246W	1.00413	REI1	YMR246W|FAA4|S000004860|Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YGR020C	1.003	REI1	YGR020C|VMA7|S000003252|Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YGR050C	0.99208	REI1	YGR050C||S000003282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL037C	0.982394	REI1	YGL037C|PNC1|S000003005|Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
YJL007C	0.980896	REI1	YJL007C||S000003544|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR013C	0.976711	REI1	YNR013C|PHO91|S000005296|Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YLR312W-A	0.973282	REI1	YLR312W-A|MRPL15|S000004304|Mitochondrial ribosomal protein of the large subunit
YJR114W	0.970957	REI1	YJR114W||S000003875|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YFL022C	0.959119	REI1	YFL022C|FRS2|S000001872|Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YKR066C	0.953669	REI1	YKR066C|CCP1|S000001774|Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YML004C	0.949495	REI1	YML004C|GLO1|S000004463|Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
YDR245W	0.94461	REI1	YDR245W|MNN10|S000002653|Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
YOR013W	0.938544	REI1	YOR013W|IRC11|S000005539|Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YNL030W	0.933917	REI1	YNL030W|HHF2|S000004975|One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YDR002W	0.929906	REI1	YDR002W|YRB1|S000002409|Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YOR320C	0.9289	REI1	YOR320C|GNT1|S000005847|N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
YGR131W	0.92635	REI1	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YDR385W	0.926268	REI1	YDR385W|EFT2|S000002793|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YHR025W	0.903829	REI1	YHR025W|THR1|S000001067|Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YPR148C	0.897459	REI1	YPR148C||S000006352|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER182W	0.896397	REI1	YER182W|FMP10|S000000984|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL301C	0.896033	REI1	YNL301C|RPL18B|S000005245|Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YML102W	0.895303	REI1	YML102W|CAC2|S000004570|Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
YLR012C	0.89039	REI1	YLR012C||S000004002|Putative protein of unknown function; YLR012C is not an essential gene
YLR029C	0.888168	REI1	YLR029C|RPL15A|S000004019|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YLR206W	0.888093	REI1	YLR206W|ENT2|S000004196|Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YDR381W	0.886884	REI1	YDR381W|YRA1|S000002789|Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YGL040C	0.881311	REI1	YGL040C|HEM2|S000003008|Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YMR194C-A	0.873328	REI1	YMR194C-A||S000007250|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER019C-A	0.866853	REI1	YER019C-A|SBH2|S000002127|Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YGR264C	0.856026	REI1	YGR264C|MES1|S000003496|Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YMR083W	0.855018	REI1	YMR083W|ADH3|S000004688|Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YOL030W	0.845911	REI1	YOL030W|GAS5|S000005390|1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YOR376W-A	0.836583	REI1	YOR376W-A||S000028586|Putative protein of unknown function; identified by fungal homology and RT-PCR
YOR047C	0.826596	REI1	YOR047C|STD1|S000005573|Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YGL082W	0.824469	REI1	YGL082W||S000003050|Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
YAL029C	0.815468	REI1	YAL029C|MYO4|S000000027|One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YCR031C	0.809762	REI1	YCR031C|RPS14A|S000000627|Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YKL127W	0.801266	REI1	YKL127W|PGM1|S000001610|Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YPL015C	0.792529	REI1	YPL015C|HST2|S000005936|Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YGR266W	0.781866	REI1	YGR266W||S000003498|Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YJR009C	0.777447	REI1	YJR009C|TDH2|S000003769|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YDL101C	0.777214	REI1	YDL101C|DUN1|S000002259|Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
YOR293W	0.773997	REI1	YOR293W|RPS10A|S000005819|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YGL039W	0.772883	REI1	YGL039W||S000003007|Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YMR265C	0.76457	REI1	YMR265C||S000004878|Putative protein of unknown function
YCR024C-B	0.762389	REI1	YCR024C-B||S000028818|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YMR296C	0.761948	REI1	YMR296C|LCB1|S000004911|Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YKL097C	0.761789	REI1	YKL097C||S000001580|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YKR075C	0.760853	REI1	YKR075C||S000001783|Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YBR118W	0.759325	REI1	YBR118W|TEF2|S000000322|Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YDR450W	0.759035	REI1	YDR450W|RPS18A|S000002858|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YGR247W	0.757532	REI1	YGR247W|CPD1|S000003479|Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression
YAL003W	0.748014	REI1	YAL003W|EFB1|S000000003|Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YBR048W	0.747948	REI1	YBR048W|RPS11B|S000000252|Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YGL068W	0.746573	REI1	YGL068W|MNP1|S000003036|Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
YKL044W	0.739477	REI1	YKL044W||S000001527|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR031C-A	0.738316	REI1	YGR031C-A|NAG1|S000028636|Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; null is hypersensitive to calcofluor white; overlaps the uncharacterized ORF YGR031W
YGR106C	0.738188	REI1	YGR106C|VOA1|S000003338|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YGR194C	0.735539	REI1	YGR194C|XKS1|S000003426|Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
YPL225W	0.73413	REI1	YPL225W||S000006146|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR265W	0.723887	REI1	YGR265W||S000003497|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YPR194C	0.723851	REI1	YPR194C|OPT2|S000006398|Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans
YDL191W	0.719749	REI1	YDL191W|RPL35A|S000002350|Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YBR149W	0.717843	REI1	YBR149W|ARA1|S000000353|NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YAR002C-A	0.712009	REI1	YAR002C-A|ERP1|S000002129|Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YNR003C	0.709053	REI1	YNR003C|RPC34|S000005286|RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YGL255W	0.704677	REI1	YGL255W|ZRT1|S000003224|High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YDR435C	0.70293	REI1	YDR435C|PPM1|S000002843|Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
YDR278C	0.702577	REI1	YDR278C||S000002686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR027C	0.702242	REI1	YIR027C|DAL1|S000001466|Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YMR251W-A	0.701763	REI1	YMR251W-A|HOR7|S000004864|Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YIL163C	0.70057	REI1	YIL163C||S000001425|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR316C-A	0.697952	REI1	YOR316C-A||S000028584|Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR050C	0.692121	REI1	YDR050C|TPI1|S000002457|Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YNL043C	0.692099	REI1	YNL043C||S000004988|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YNL134C	0.691214	REI1	YNL134C||S000005078|Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YHR020W	0.691167	REI1	YHR020W||S000001062|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
YDR225W	0.685507	REI1	YDR225W|HTA1|S000002633|One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YGL229C	0.66954	REI1	YGL229C|SAP4|S000003198|Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
YJL008C	0.668176	REI1	YJL008C|CCT8|S000003545|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YPL108W	0.667091	REI1	YPL108W||S000006029|Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YJL167W	0.666856	REI1	YJL167W|ERG20|S000003703|Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YPL239W	0.665809	REI1	YPL239W|YAR1|S000006160|Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YOL015W	0.664533	REI1	YOL015W|IRC10|S000005375|Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YHR087W	0.662825	REI1	YHR087W|RTC3|S000001129|Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YLR154W-A	0.662199	REI1	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YJR001W	0.65758	REI1	YJR001W|AVT1|S000003761|Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YGL103W	0.651794	REI1	YGL103W|RPL28|S000003071|Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YOR008C-A	0.651759	REI1	YOR008C-A||S000006431|Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YGL070C	0.65162	REI1	YGL070C|RPB9|S000003038|RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
YCR085W	0.648357	REI1	YCR085W||S000000681|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL043W	0.63936	REI1	YKL043W|PHD1|S000001526|Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YGL161C	0.638904	REI1	YGL161C|YIP5|S000003129|Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YDR509W	0.637538	REI1	YDR509W||S000002917|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR217W	0.63253	REI1	YMR217W|GUA1|S000004830|GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YIL169C	0.630782	REI1	YIL169C||S000001431|Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YNL010W	0.6297	REI1	YNL010W||S000004955|Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
YNL320W	0.629456	REI1	YNL320W||S000005264|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR508C	0.628886	REI1	YDR508C|GNP1|S000002916|High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YJL029C	0.628752	REI1	YJL029C|VPS53|S000003566|Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YEL051W	0.627037	REI1	YEL051W|VMA8|S000000777|Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YDR531W	0.625498	REI1	YDR531W||S000002939|Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YOR092W	0.625439	REI1	YOR092W|ECM3|S000005618|Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YOR342C	0.625102	REI1	YOR342C||S000005869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YJL178C	0.624113	REI1	YJL178C|ATG27|S000003714|Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the pre-autophagosomal structure; binds phosphatidylinositol 3-phosphate
YGR181W	0.6211	REI1	YGR181W|TIM13|S000003413|Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YDR046C	0.613207	REI1	YDR046C|BAP3|S000002453|Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YKL065C	0.602233	REI1	YKL065C|YET1|S000001548|Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YKL014C	0.599099	REI1	YKL014C|URB1|S000001497|Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YMR173W	0.598733	REI1	YMR173W|DDR48|S000004784|DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
YOL016C	0.59619	REI1	YOL016C|CMK2|S000005376|Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YPL075W	0.592067	REI1	YPL075W|GCR1|S000005996|Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YNL073W	0.589956	REI1	YNL073W|MSK1|S000005017|Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
YOL059W	0.588767	REI1	YOL059W|GPD2|S000005420|NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YOR161C	0.588554	REI1	YOR161C|PNS1|S000005687|Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
YDR032C	0.584323	REI1	YDR032C|PST2|S000002439|Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR215C	0.581091	REI1	YDR215C||S000002623|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YHL002W	0.580545	REI1	YHL002W|HSE1|S000000994|Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YKL068W-A	0.578703	REI1	YKL068W-A||S000028524|Putative protein of unknown function; identified by homology to Ashbya gossypii
YPL224C	0.57809	REI1	YPL224C|MMT2|S000006145|Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YER081W	0.57661	REI1	YER081W|SER3|S000000883|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p
YMR173W-A	0.573051	REI1	YMR173W-A||S000004785|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W
YKL037W	0.568345	REI1	YKL037W|AIM26|S000001520|Putative protein of unknown function; null mutant is viable and displays increased frequency of mitochondrial genome loss (petite formation)
YOR292C	0.562077	REI1	YOR292C||S000005818|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
YDR098C	0.558649	REI1	YDR098C|GRX3|S000002505|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPR074W-A	0.557868	REI1	YPR074W-A||S000007631|Hypothetical protein identified by homology
YNL031C	0.5555	REI1	YNL031C|HHT2|S000004976|One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YKL218C	0.55484	REI1	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YEL020C-B	0.553664	REI1	YEL020C-B||S000028544|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YGR008C	0.551569	REI1	YGR008C|STF2|S000003240|Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YJL193W	0.551312	REI1	YJL193W||S000003729|Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YDR158W	0.547519	REI1	YDR158W|HOM2|S000002565|Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YGR180C	0.546901	REI1	YGR180C|RNR4|S000003412|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YLR056W	0.54448	REI1	YLR056W|ERG3|S000004046|C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YJL177W	0.540296	REI1	YJL177W|RPL17B|S000003713|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YPL154C	0.532241	REI1	YPL154C|PEP4|S000006075|Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
YLR413W	0.5294	REI1	YLR413W||S000004405|Putative protein of unknown function; YLR413W is not an essential gene
YPR156C	0.527715	REI1	YPR156C|TPO3|S000006360|Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YDR284C	0.527062	REI1	YDR284C|DPP1|S000002692|Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YLR110C	0.526387	REI1	YLR110C|CCW12|S000004100|Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YJR145C	0.521058	REI1	YJR145C|RPS4A|S000003906|Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YDR047W	0.519168	REI1	YDR047W|HEM12|S000002454|Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YDR129C	0.51821	REI1	YDR129C|SAC6|S000002536|Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YFR031C-A	0.51741	REI1	YFR031C-A|RPL2A|S000002104|Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YNL130C	0.515759	REI1	YNL130C|CPT1|S000005074|Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YGR111W	0.512334	REI1	YGR111W||S000003343|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR134W	0.512244	REI1	YOR134W|BAG7|S000005660|Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p
YJL133W	0.508011	REI1	YJL133W|MRS3|S000003669|Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron
YHL002C-A	0.504239	REI1	YHL002C-A||S000028770|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR354C	0.504139	REI1	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL150W	0.498979	REI1	YKL150W|MCR1|S000001633|Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
YEL017W	0.49834	REI1	YEL017W|GTT3|S000000743|Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YLR333C	0.495496	REI1	YLR333C|RPS25B|S000004325|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YPR062W	0.491248	REI1	YPR062W|FCY1|S000006266|Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YHR104W	0.489314	REI1	YHR104W|GRE3|S000001146|Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YHR019C	0.480362	REI1	YHR019C|DED81|S000001061|Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YBR263W	0.478157	REI1	YBR263W|SHM1|S000000467|Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YOR272W	0.476239	REI1	YOR272W|YTM1|S000005798|Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YHR009C	0.46674	REI1	YHR009C||S000001051|Putative protein of unknown function; not an essential gene
YAR003W	0.465976	REI1	YAR003W|SWD1|S000000064|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
YLR325C	0.465528	REI1	YLR325C|RPL38|S000004317|Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YDL047W	0.464832	REI1	YDL047W|SIT4|S000002205|Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YFL016C	0.463607	REI1	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YCR012W	0.460938	REI1	YCR012W|PGK1|S000000605|3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YIR021W	0.45895	REI1	YIR021W|MRS1|S000001460|Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKL009W	0.454405	REI1	YKL009W|MRT4|S000001492|Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YHR083W	0.45284	REI1	YHR083W|SAM35|S000001125|Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YOR230W	0.452581	REI1	YOR230W|WTM1|S000005756|Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
YPL007C	0.452354	REI1	YPL007C|TFC8|S000005928|One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
YMR042W	0.451637	REI1	YMR042W|ARG80|S000004645|Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
YOR321W	0.449893	REI1	YOR321W|PMT3|S000005848|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals
YMR122W-A	0.449583	REI1	YMR122W-A||S000007524|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YCR050C	0.44834	REI1	YCR050C||S000000646|Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
YEL039C	0.434732	REI1	YEL039C|CYC7|S000000765|Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YDL048C	0.43353	REI1	YDL048C|STP4|S000002206|Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YGL147C	0.432205	REI1	YGL147C|RPL9A|S000003115|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YGL209W	0.429277	REI1	YGL209W|MIG2|S000003177|Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YLR212C	0.42757	REI1	YLR212C|TUB4|S000004202|Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YCR022C	0.419081	REI1	YCR022C||S000000616|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YCL064C	0.416772	REI1	YCL064C|CHA1|S000000569|Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YOL031C	0.416414	REI1	YOL031C|SIL1|S000005391|Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YNL263C	0.408901	REI1	YNL263C|YIF1|S000005207|Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles
YBR154C	0.408519	REI1	YBR154C|RPB5|S000000358|RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YIR013C	0.40766	REI1	YIR013C|GAT4|S000001452|Protein containing GATA family zinc finger motifs
YDL129W	0.407012	REI1	YDL129W||S000002287|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene
YLR446W	0.405464	REI1	YLR446W||S000004438|Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
YAR071W	0.405018	REI1	YAR071W|PHO11|S000000094|One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YHR140W	0.399712	REI1	YHR140W||S000001182|Putative integral membrane protein of unknown function
YMR258C	0.39902	REI1	YMR258C||S000004871|Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene
YIL050W	0.398812	REI1	YIL050W|PCL7|S000001312|Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YBR161W	0.397742	REI1	YBR161W|CSH1|S000000365|Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p
YPR028W	0.396338	REI1	YPR028W|YOP1|S000006232|Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YMR199W	0.393917	REI1	YMR199W|CLN1|S000004812|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOR131C	0.393246	REI1	YOR131C||S000005657|Putative protein of unknown function; non-essential gene
YDR233C	0.392557	REI1	YDR233C|RTN1|S000002641|ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; also interacts with Sbh1p; null mutant has an altered (mostly cisternal) ER morphology; member of the RTNLA (reticulon-like A) subfamily
YHR201C	0.392556	REI1	YHR201C|PPX1|S000001244|Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YCR051W	0.390422	REI1	YCR051W||S000000647|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YLL023C	0.389288	REI1	YLL023C||S000003946|Protein of unknown function; highly conserved across species and orthologous to human TMEM33; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the endoplasmic reticulum
YML100W	0.386165	REI1	YML100W|TSL1|S000004566|Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YOR101W	0.385317	REI1	YOR101W|RAS1|S000005627|GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YGL104C	0.384941	REI1	YGL104C|VPS73|S000003072|Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YFR051C	0.384568	REI1	YFR051C|RET2|S000001947|Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YDL072C	0.382732	REI1	YDL072C|YET3|S000002230|Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein
YDL024C	0.380885	REI1	YDL024C|DIA3|S000002182|Protein of unknown function, involved in invasive and pseudohyphal growth
YKL051W	0.377019	REI1	YKL051W|SFK1|S000001534|Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YHR092C	0.374107	REI1	YHR092C|HXT4|S000001134|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YNR053C	0.372972	REI1	YNR053C|NOG2|S000005336|Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YGL055W	0.37006	REI1	YGL055W|OLE1|S000003023|Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YJL136C	0.368034	REI1	YJL136C|RPS21B|S000003672|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YNL045W	0.359756	REI1	YNL045W||S000004990|Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOL130W	0.359257	REI1	YOL130W|ALR1|S000005490|Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YER147C-A	0.358621	REI1	YER147C-A||S000028759|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL077W	0.357998	REI1	YBL077W||S000000173|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YGR068C	0.356876	REI1	YGR068C||S000003300|Putative protein of unknown function; YGR068C is not an essential gene.
YOR029W	0.356262	REI1	YOR029W||S000005555|Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL004C	0.35315	REI1	YPL004C|LSP1|S000005925|Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YBR210W	0.352598	REI1	YBR210W|ERV15|S000000414|Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YMR303C	0.352226	REI1	YMR303C|ADH2|S000004918|Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YBR178W	0.347307	REI1	YBR178W||S000000382|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YNL048W	0.346696	REI1	YNL048W|ALG11|S000004993|Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER
YGR195W	0.339794	REI1	YGR195W|SKI6|S000003427|3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YLR075W	0.336034	REI1	YLR075W|RPL10|S000004065|Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YDR023W	0.334659	REI1	YDR023W|SES1|S000002430|Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YLR436C	0.33353	REI1	YLR436C|ECM30|S000004428|Non-essential protein of unknown function
YBR032W	0.329829	REI1	YBR032W||S000000236|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YLR089C	0.329143	REI1	YLR089C|ALT1|S000004079|Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR418W	0.328141	REI1	YDR418W|RPL12B|S000002826|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YHR182C-A	0.327698	REI1	YHR182C-A||S000028784|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL103W	0.323521	REI1	YOL103W|ITR2|S000005463|Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YOR277C	0.322047	REI1	YOR277C||S000005803|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YMR319C	0.321725	REI1	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YML119W	0.321588	REI1	YML119W||S000004588|Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YMR169C	0.320832	REI1	YMR169C|ALD3|S000004779|Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YJR025C	0.316069	REI1	YJR025C|BNA1|S000003786|3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YPL003W	0.315495	REI1	YPL003W|ULA1|S000005924|Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
YAR020C	0.315343	REI1	YAR020C|PAU7|S000000073|Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YHR183W	0.313395	REI1	YHR183W|GND1|S000001226|6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YBR093C	0.312707	REI1	YBR093C|PHO5|S000000297|Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YLR108C	0.312106	REI1	YLR108C||S000004098|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YMR315W	0.311381	REI1	YMR315W||S000004932|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene
YML054C-A	0.310833	REI1	YML054C-A||S000028573|Putative protein of unknown function
YKL007W	0.310372	REI1	YKL007W|CAP1|S000001490|Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YMR049C	0.309343	REI1	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YPL257W	0.308962	REI1	YPL257W||S000006178|Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YEL058W	0.308705	REI1	YEL058W|PCM1|S000000784|Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YEL063C	0.308452	REI1	YEL063C|CAN1|S000000789|Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
YEL066W	0.306693	REI1	YEL066W|HPA3|S000000792|D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YDL124W	0.303984	REI1	YDL124W||S000002282|NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YDR533C	0.300206	REI1	YDR533C|HSP31|S000002941|Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YML120C	0.299206	REI1	YML120C|NDI1|S000004589|NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YJR086W	0.29903	REI1	YJR086W|STE18|S000003846|G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
YGR248W	0.297177	REI1	YGR248W|SOL4|S000003480|6-phosphogluconolactonase with similarity to Sol3p
YKL096W	0.296613	REI1	YKL096W|CWP1|S000001579|Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YML075C	0.295222	REI1	YML075C|HMG1|S000004540|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YPR064W	0.294543	REI1	YPR064W||S000006268|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR195W	0.292308	REI1	YHR195W|NVJ1|S000001238|Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
YLR455W	0.28847	REI1	YLR455W||S000004447|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YER122C	0.287227	REI1	YER122C|GLO3|S000000924|ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
YDR465C	0.286762	REI1	YDR465C|RMT2|S000002873|Arginine methyltransferase; ribosomal protein L12 is a substrate
YDR391C	0.286687	REI1	YDR391C||S000002799|Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YKL152C	0.286155	REI1	YKL152C|GPM1|S000001635|Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YGL201C	0.281608	REI1	YGL201C|MCM6|S000003169|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YMR122C	0.280753	REI1	YMR122C||S000004729|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL004W	0.27841	REI1	YHL004W|MRP4|S000000996|Mitochondrial ribosomal protein of the small subunit
YGR036C	0.276145	REI1	YGR036C|CAX4|S000003268|Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YJL107C	0.276044	REI1	YJL107C||S000003643|Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YBR254C	0.275854	REI1	YBR254C|TRS20|S000000458|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
YGR253C	0.275796	REI1	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YDL195W	0.274799	REI1	YDL195W|SEC31|S000002354|Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation
YLR027C	0.274565	REI1	YLR027C|AAT2|S000004017|Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YPR165W	0.274501	REI1	YPR165W|RHO1|S000006369|GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YDR156W	0.273366	REI1	YDR156W|RPA14|S000002563|RNA polymerase I subunit A14
YMR032W	0.273179	REI1	YMR032W|HOF1|S000004635|Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YDR247W	0.27206	REI1	YDR247W|VHS1|S000002655|Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YGR124W	0.271707	REI1	YGR124W|ASN2|S000003356|Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YLR013W	0.271416	REI1	YLR013W|GAT3|S000004003|Protein containing GATA family zinc finger motifs
YKL119C	0.270591	REI1	YKL119C|VPH2|S000001602|Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YIL123W	0.269215	REI1	YIL123W|SIM1|S000001385|Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YER137C	0.269155	REI1	YER137C||S000000939|Putative protein of unknown function
YPL117C	0.26908	REI1	YPL117C|IDI1|S000006038|Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
YBR286W	0.26858	REI1	YBR286W|APE3|S000000490|Vacuolar aminopeptidase Y, processed to mature form by Prb1p
YKL153W	0.268489	REI1	YKL153W||S000001636|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YOR247W	0.267632	REI1	YOR247W|SRL1|S000005773|Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YIL137C	0.266666	REI1	YIL137C|TMA108|S000001399|Protein that associates with ribosomes; putative metalloprotease
YGR218W	0.263129	REI1	YGR218W|CRM1|S000003450|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
YLR372W	0.262628	REI1	YLR372W|SUR4|S000004364|Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YFR021W	0.260779	REI1	YFR021W|ATG18|S000001917|Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
YGR031W	0.259781	REI1	YGR031W||S000003263|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR139W	0.259168	REI1	YBR139W||S000000343|Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YDL126C	0.257752	REI1	YDL126C|CDC48|S000002284|ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
YOR028C	0.256818	REI1	YOR028C|CIN5|S000005554|Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YBL092W	0.256389	REI1	YBL092W|RPL32|S000000188|Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YDR099W	0.256184	REI1	YDR099W|BMH2|S000002506|14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YCR006C	0.252942	REI1	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL158W	0.252053	REI1	YGL158W|RCK1|S000003126|Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YER148W	0.24855	REI1	YER148W|SPT15|S000000950|TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YDR349C	0.246189	REI1	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YLR355C	0.245039	REI1	YLR355C|ILV5|S000004347|Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YOR049C	0.244911	REI1	YOR049C|RSB1|S000005575|Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YER178W	0.238528	REI1	YER178W|PDA1|S000000980|E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
YGR155W	0.238477	REI1	YGR155W|CYS4|S000003387|Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YPL095C	0.238262	REI1	YPL095C|EEB1|S000006016|Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification
YCL063W	0.236934	REI1	YCL063W|VAC17|S000000568|Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YOR375C	0.236393	REI1	YOR375C|GDH1|S000005902|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YDR408C	0.23516	REI1	YDR408C|ADE8|S000002816|Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YJL141C	0.234441	REI1	YJL141C|YAK1|S000003677|Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
YJR010W	0.233277	REI1	YJR010W|MET3|S000003771|ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YER168C	0.233188	REI1	YER168C|CCA1|S000000970|ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
YGR269W	0.231337	REI1	YGR269W||S000003501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
YPL145C	0.22937	REI1	YPL145C|KES1|S000006066|Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
YOR106W	0.227422	REI1	YOR106W|VAM3|S000005632|Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
YMR281W	0.22676	REI1	YMR281W|GPI12|S000004894|ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YIL133C	0.225792	REI1	YIL133C|RPL16A|S000001395|N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YLL028W	0.225113	REI1	YLL028W|TPO1|S000003951|Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YHL015W	0.224378	REI1	YHL015W|RPS20|S000001007|Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YJL151C	0.222665	REI1	YJL151C|SNA3|S000003687|Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YKR038C	0.222074	REI1	YKR038C|KAE1|S000001746|Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YPR069C	0.222056	REI1	YPR069C|SPE3|S000006273|Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YIL015W	0.221908	REI1	YIL015W|BAR1|S000001277|Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YHR142W	0.22182	REI1	YHR142W|CHS7|S000001184|Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YLR347C	0.221608	REI1	YLR347C|KAP95|S000004339|Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex
YKR092C	0.219294	REI1	YKR092C|SRP40|S000001800|Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YCR004C	0.219268	REI1	YCR004C|YCP4|S000000597|Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR052C	0.219242	REI1	YBR052C|RFS1|S000000256|Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR015C	0.21833	REI1	YMR015C|ERG5|S000004617|C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YNL055C	0.214457	REI1	YNL055C|POR1|S000005000|Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YMR119W	0.214408	REI1	YMR119W|ASI1|S000004725|Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YLL055W	0.213981	REI1	YLL055W|YCT1|S000003978|High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YML124C	0.212474	REI1	YML124C|TUB3|S000004593|Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YOR095C	0.212071	REI1	YOR095C|RKI1|S000005621|Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YKL013C	0.211973	REI1	YKL013C|ARC19|S000001496|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YOL022C	0.21193	REI1	YOL022C|TSR4|S000005382|Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YER181C	0.211196	REI1	YER181C||S000000983|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
YMR320W	0.20986	REI1	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR047C	0.209578	REI1	YHR047C|AAP1|S000001089|Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YIR020C	0.208184	REI1	YIR020C||S000001459|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR058C	0.207218	REI1	YJR058C|APS2|S000003819|Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
YBR207W	0.207065	REI1	YBR207W|FTH1|S000000411|Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis
YNL307C	0.206739	REI1	YNL307C|MCK1|S000005251|Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
YCR023C	0.206705	REI1	YCR023C||S000000617|Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
YLL049W	0.205852	REI1	YLL049W|LDB18|S000003972|Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YLR183C	0.205405	REI1	YLR183C|TOS4|S000004173|Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YNR004W	0.204552	REI1	YNR004W||S000005287|Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C
YOR299W	0.204517	REI1	YOR299W|BUD7|S000005825|Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YCR102W-A	0.20371	REI1	YCR102W-A||S000007231|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR120C	0.203372	REI1	YLR120C|YPS1|S000004110|Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YDL146W	0.203235	REI1	YDL146W|LDB17|S000002305|Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YBR015C	0.201971	REI1	YBR015C|MNN2|S000000219|Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YKL117W	0.201634	REI1	YKL117W|SBA1|S000001600|Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YLL063C	0.200516	REI1	YLL063C|AYT1|S000003986|Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
YPR181C	0.199891	REI1	YPR181C|SEC23|S000006385|GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p
YER094C	0.19974	REI1	YER094C|PUP3|S000000896|Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YJL217W	0.199527	REI1	YJL217W||S000003753|Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YGR125W	0.199246	REI1	YGR125W||S000003357|Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YJR057W	0.198591	REI1	YJR057W|CDC8|S000003818|Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YGR161W-C	0.198223	REI1	YGR161W-C||S000029726|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YLR009W	0.196982	REI1	YLR009W|RLP24|S000003999|Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YBL031W	0.196767	REI1	YBL031W|SHE1|S000000127|Cytoskeletal protein of unknown function; overexpression causes growth arrest
YER156C	0.196417	REI1	YER156C||S000000958|Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YFR052W	0.1964	REI1	YFR052W|RPN12|S000001948|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
YML132W	0.195375	REI1	YML132W|COS3|S000004601|Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YEL068C	0.194925	REI1	YEL068C||S000000794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR305C	0.192454	REI1	YMR305C|SCW10|S000004921|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YFL005W	0.191225	REI1	YFL005W|SEC4|S000001889|Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YDL137W	0.190772	REI1	YDL137W|ARF2|S000002296|ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p
YLR412C-A	0.189894	REI1	YLR412C-A||S000028572|Putative protein of unknown function
YGL162W	0.189543	REI1	YGL162W|SUT1|S000003130|Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YLR113W	0.187656	REI1	YLR113W|HOG1|S000004103|Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YIL054W	0.18558	REI1	YIL054W||S000001316|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR106C	0.185138	REI1	YMR106C|YKU80|S000004712|Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YOR385W	0.185094	REI1	YOR385W||S000005912|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
YKR093W	0.184993	REI1	YKR093W|PTR2|S000001801|Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YJL213W	0.184347	REI1	YJL213W||S000003749|Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YNL035C	0.182416	REI1	YNL035C||S000004980|Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YPL245W	0.182153	REI1	YPL245W||S000006166|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YJL222W-A	0.180919	REI1	YJL222W-A||S000028663|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL039W	0.180853	REI1	YOL039W|RPP2A|S000005399|Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YCR045C	0.180113	REI1	YCR045C||S000000641|Putative protein of unknown function
YOL081W	0.180069	REI1	YOL081W|IRA2|S000005441|GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YBR066C	0.179073	REI1	YBR066C|NRG2|S000000270|Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YJL028W	0.178694	REI1	YJL028W||S000003565|Protein of unknown function; may interact with ribosomes, based on co-purification experiments
YPL109C	0.178694	REI1	YPL109C||S000006030|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER133W	0.177667	REI1	YER133W|GLC7|S000000935|Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YMR243C	0.177519	REI1	YMR243C|ZRC1|S000004856|Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
YKL118W	0.177129	REI1	YKL118W||S000001601|Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YLR421C	0.176336	REI1	YLR421C|RPN13|S000004413|Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome
YLR062C	0.175122	REI1	YLR062C|BUD28|S000004052|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YDR110W	0.17511	REI1	YDR110W|FOB1|S000002517|Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
YGR255C	0.174883	REI1	YGR255C|COQ6|S000003487|Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YMR267W	0.174706	REI1	YMR267W|PPA2|S000004880|Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
YFR004W	0.173058	REI1	YFR004W|RPN11|S000001900|Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates
YHR124W	0.172587	REI1	YHR124W|NDT80|S000001166|Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YJR127C	0.172063	REI1	YJR127C|RSF2|S000003888|Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions
YER003C	0.171821	REI1	YER003C|PMI40|S000000805|Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YDL078C	0.168146	REI1	YDL078C|MDH3|S000002236|Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YOL005C	0.167945	REI1	YOL005C|RPB11|S000005365|RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YBR130C	0.167759	REI1	YBR130C|SHE3|S000000334|Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YNL275W	0.166585	REI1	YNL275W|BOR1|S000005219|Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
YNL336W	0.165319	REI1	YNL336W|COS1|S000005280|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YBR214W	0.163337	REI1	YBR214W|SDS24|S000000418|One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YEL057C	0.162632	REI1	YEL057C||S000000783|Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YOR087W	0.160822	REI1	YOR087W|YVC1|S000005613|Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
YPR080W	0.160751	REI1	YPR080W|TEF1|S000006284|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YER073W	0.160615	REI1	YER073W|ALD5|S000000875|Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YCR101C	0.159722	REI1	YCR101C||S000000698|Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
YNL011C	0.159619	REI1	YNL011C||S000004956|Putative protein of unknown function; YNL011C is not an essential gene
YHL034C	0.159182	REI1	YHL034C|SBP1|S000001026|Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
YMR121C	0.158754	REI1	YMR121C|RPL15B|S000004728|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YOR280C	0.158343	REI1	YOR280C|FSH3|S000005806|Serine hydrolase; sequence is similar to Fsh1p and Fsh2p
YDR157W	0.157693	REI1	YDR157W||S000002564|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL009C-A	0.157262	REI1	YIL009C-A|EST3|S000006432|Component of the telomerase holoenzyme, involved in telomere replication
YIL056W	0.157143	REI1	YIL056W|VHR1|S000001318|Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YNL219C	0.156354	REI1	YNL219C|ALG9|S000005163|Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
YNL241C	0.156352	REI1	YNL241C|ZWF1|S000005185|Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YPR029C	0.155488	REI1	YPR029C|APL4|S000006233|Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YHR024C	0.154171	REI1	YHR024C|MAS2|S000001066|Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YML051W	0.153031	REI1	YML051W|GAL80|S000004515|Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
YBR027C	0.1527	REI1	YBR027C||S000000231|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL052W	0.152454	REI1	YEL052W|AFG1|S000000778|Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YGL256W	0.152135	REI1	YGL256W|ADH4|S000003225|Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YJL011C	0.152033	REI1	YJL011C|RPC17|S000003548|RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YDR154C	0.150492	REI1	YDR154C||S000002561|Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YGR094W	0.150422	REI1	YGR094W|VAS1|S000003326|Mitochondrial and cytoplasmic valyl-tRNA synthetase
YPL246C	0.149663	REI1	YPL246C|RBD2|S000006167|Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
YGL238W	0.148233	REI1	YGL238W|CSE1|S000003207|Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YLR076C	0.147697	REI1	YLR076C||S000004066|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YJL068C	0.146135	REI1	YJL068C||S000003604|Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YGR030C	0.145752	REI1	YGR030C|POP6|S000003262|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YGR060W	0.145664	REI1	YGR060W|ERG25|S000003292|C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YER146W	0.145387	REI1	YER146W|LSM5|S000000948|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YGR090W	0.144942	REI1	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YDR206W	0.144934	REI1	YDR206W|EBS1|S000002614|Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
YPL265W	0.143928	REI1	YPL265W|DIP5|S000006186|Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YDR224C	0.143925	REI1	YDR224C|HTB1|S000002632|One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YJR101W	0.14368	REI1	YJR101W|RSM26|S000003862|Mitochondrial ribosomal protein of the small subunit
YER028C	0.143172	REI1	YER028C|MIG3|S000000830|Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YGR270C-A	0.143024	REI1	YGR270C-A||S000028641|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W
YGL063W	0.142666	REI1	YGL063W|PUS2|S000003031|Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
YIL145C	0.141059	REI1	YIL145C|PAN6|S000001407|Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YNL044W	0.140295	REI1	YNL044W|YIP3|S000004989|Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
YBR298C	0.140103	REI1	YBR298C|MAL31|S000000502|Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
YDL145C	0.140053	REI1	YDL145C|COP1|S000002304|Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YKL151C	0.139022	REI1	YKL151C||S000001634|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJR133W	0.138571	REI1	YJR133W|XPT1|S000003894|Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
YPL272C	0.137973	REI1	YPL272C||S000006193|Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YJR085C	0.13763	REI1	YJR085C||S000003845|Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR367W	0.137603	REI1	YLR367W|RPS22B|S000004359|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YIL059C	0.137592	REI1	YIL059C||S000001321|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YOL161C	0.136679	REI1	YOL161C|PAU20|S000005521|Hypothetical protein
YNL138W	0.135199	REI1	YNL138W|SRV2|S000005082|CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
YNL162W	0.1341	REI1	YNL162W|RPL42A|S000005106|Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YOR009W	0.133965	REI1	YOR009W|TIR4|S000005535|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
YOR315W	0.133486	REI1	YOR315W|SFG1|S000005842|Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YER102W	0.133037	REI1	YER102W|RPS8B|S000000904|Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YDL100C	0.131921	REI1	YDL100C|GET3|S000002258|Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking; has low-level ATPase activity and is involved in resistance to heat and metal stress
YIL108W	0.131567	REI1	YIL108W||S000001370|Putative metalloprotease
YJL212C	0.130791	REI1	YJL212C|OPT1|S000003748|Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YPR038W	0.130753	REI1	YPR038W|IRC16|S000006242|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci
YNL302C	0.130388	REI1	YNL302C|RPS19B|S000005246|Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YIL109C	0.129774	REI1	YIL109C|SEC24|S000001371|Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p
YFR011C	0.129593	REI1	YFR011C|AIM13|S000001907|Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media
YPL012W	0.128634	REI1	YPL012W|RRP12|S000005933|Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats
YML122C	0.128484	REI1	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR039C	0.127336	REI1	YMR039C|SUB1|S000004642|Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations
YBR026C	0.126026	REI1	YBR026C|ETR1|S000000230|2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
YIL096C	0.125891	REI1	YIL096C||S000001358|Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YCL021W-A	0.125622	REI1	YCL021W-A||S000007549|Putative protein of unknown function
YIL066W-A	0.125541	REI1	YIL066W-A||S000028791|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR167C	0.125532	REI1	YOR167C|RPS28A|S000005693|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein
YOR019W	0.125444	REI1	YOR019W||S000005545|Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YOL121C	0.124889	REI1	YOL121C|RPS19A|S000005481|Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YML130C	0.124637	REI1	YML130C|ERO1|S000004599|Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YML123C	0.124548	REI1	YML123C|PHO84|S000004592|High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YLR220W	0.124537	REI1	YLR220W|CCC1|S000004210|Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation
YGR149W	0.124185	REI1	YGR149W||S000003381|Putative protein of unknown function; predicted to be an integal membrane protein
YLR450W	0.124184	REI1	YLR450W|HMG2|S000004442|One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks
YLR042C	0.124051	REI1	YLR042C||S000004032|Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YKL212W	0.123892	REI1	YKL212W|SAC1|S000001695|Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
YCR104W	0.123736	REI1	YCR104W|PAU3|S000000701|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR249C	0.122894	REI1	YDR249C||S000002657|Putative protein of unknown function
YPR037C	0.122212	REI1	YPR037C|ERV2|S000006241|Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
YGR121W-A	0.121978	REI1	YGR121W-A||S000028550|Putative protein of unknown function
YDR535C	0.121876	REI1	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YBR121C	0.12183	REI1	YBR121C|GRS1|S000000325|Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YPR036W	0.121447	REI1	YPR036W|VMA13|S000006240|Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
YOR271C	0.121236	REI1	YOR271C|FSF1|S000005797|Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YIL009W	0.121222	REI1	YIL009W|FAA3|S000001271|Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGR021W	0.121077	REI1	YGR021W||S000003253|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR092C	0.120833	REI1	YMR092C|AIP1|S000004698|Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats
YDR041W	0.120685	REI1	YDR041W|RSM10|S000002448|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YOR145C	0.119933	REI1	YOR145C|PNO1|S000005671|Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
YDR252W	0.119699	REI1	YDR252W|BTT1|S000002660|Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
YBR003W	0.118748	REI1	YBR003W|COQ1|S000000207|Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
YER056C-A	0.118623	REI1	YER056C-A|RPL34A|S000002135|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YEL067C	0.118237	REI1	YEL067C||S000000793|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER021W	0.116701	REI1	YER021W|RPN3|S000000823|Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YMR177W	0.116589	REI1	YMR177W|MMT1|S000004789|Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YOL129W	0.115569	REI1	YOL129W|VPS68|S000005489|Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
YLR088W	0.11456	REI1	YLR088W|GAA1|S000004078|Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
YBL087C	0.114361	REI1	YBL087C|RPL23A|S000000183|Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YGL125W	0.113499	REI1	YGL125W|MET13|S000003093|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YLR411W	0.113119	REI1	YLR411W|CTR3|S000004403|High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YIR020W-A	0.112865	REI1	YIR020W-A||S000007241|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YIL011W	0.112759	REI1	YIL011W|TIR3|S000001273|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YML003W	0.112362	REI1	YML003W||S000004462|Putative protein of unknown function
YFL054C	0.112247	REI1	YFL054C||S000001840|Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YPL006W	0.112127	REI1	YPL006W|NCR1|S000005927|Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YCR073C	0.11179	REI1	YCR073C|SSK22|S000000669|MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
YLR063W	0.111623	REI1	YLR063W||S000004053|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
YGR268C	0.111334	REI1	YGR268C|HUA1|S000003500|Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YGR148C	0.110519	REI1	YGR148C|RPL24B|S000003380|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YKR045C	0.110509	REI1	YKR045C||S000001753|Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YIL016W	0.110153	REI1	YIL016W|SNL1|S000001278|Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
YOR026W	0.110029	REI1	YOR026W|BUB3|S000005552|Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
YBR211C	0.108261	REI1	YBR211C|AME1|S000000415|Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance
YDR261C	0.107815	REI1	YDR261C|EXG2|S000002669|Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YGL262W	0.107674	REI1	YGL262W||S000003231|Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
YIR042C	0.107553	REI1	YIR042C||S000001481|Putative protein of unknown function; YIR042C is a non-essential gene
YPR170W-B	0.107356	REI1	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YIL148W	0.10708	REI1	YIL148W|RPL40A|S000001410|Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YAL067W-A	0.106141	REI1	YAL067W-A||S000028593|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDL189W	0.105949	REI1	YDL189W|RBS1|S000002348|Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YJL186W	0.105574	REI1	YJL186W|MNN5|S000003722|Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YDR179W-A	0.105242	REI1	YDR179W-A||S000002587|Putative protein of unknown function
YNL189W	0.105003	REI1	YNL189W|SRP1|S000005133|Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YNL338W	0.104877	REI1	YNL338W||S000005282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YKL062W	0.104633	REI1	YKL062W|MSN4|S000001545|Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YGR214W	0.104436	REI1	YGR214W|RPS0A|S000003446|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YDR234W	0.103785	REI1	YDR234W|LYS4|S000002642|Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YNR050C	0.102504	REI1	YNR050C|LYS9|S000005333|Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YMR058W	0.102323	REI1	YMR058W|FET3|S000004662|Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
YHR017W	0.102256	REI1	YHR017W|YSC83|S000001059|Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YBR011C	0.101562	REI1	YBR011C|IPP1|S000000215|Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YOR284W	0.101525	REI1	YOR284W|HUA2|S000005810|Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YOR096W	0.101209	REI1	YOR096W|RPS7A|S000005622|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YOR163W	0.101091	REI1	YOR163W|DDP1|S000005689|Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YNL051W	0.100948	REI1	YNL051W|COG5|S000004996|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YAL007C	0.100645	REI1	YAL007C|ERP2|S000000005|Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YBL063W	0.100642	REI1	YBL063W|KIP1|S000000159|Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YDR005C	0.0997958	REI1	YDR005C|MAF1|S000002412|Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB
YOR386W	0.0995734	REI1	YOR386W|PHR1|S000005913|DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
YGR191W	0.0992326	REI1	YGR191W|HIP1|S000003423|High-affinity histidine permease, also involved in the transport of manganese ions
YPL144W	0.0986757	REI1	YPL144W|POC4|S000006065|Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YDL046W	0.0983363	REI1	YDL046W|NPC2|S000002204|Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
YER087C-B	0.0975034	REI1	YER087C-B|SBH1|S000002128|Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p
YOR168W	0.0964349	REI1	YOR168W|GLN4|S000005694|Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
YNL015W	0.0961561	REI1	YNL015W|PBI2|S000004960|Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
YPR170W-A	0.0961431	REI1	YPR170W-A||S000028861|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YER133W-A	0.0959432	REI1	YER133W-A||S000028756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YER057C	0.0958469	REI1	YER057C|HMF1|S000000859|Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
YLR008C	0.095758	REI1	YLR008C|PAM18|S000003998|J-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p
YFR024C-A	0.0956071	REI1	YFR024C-A|LSB3|S000002968|Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YLR002C	0.0955179	REI1	YLR002C|NOC3|S000003992|Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YER036C	0.0946679	REI1	YER036C|ARB1|S000000838|ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YBL055C	0.0942841	REI1	YBL055C||S000000151|3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YDR009W	0.0930715	REI1	YDR009W|GAL3|S000002416|Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YDR307W	0.0926936	REI1	YDR307W||S000002715|Putative protein of unknown function
YGL257C	0.0925587	REI1	YGL257C|MNT2|S000003226|Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YOR278W	0.0922832	REI1	YOR278W|HEM4|S000005804|Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway
YNL264C	0.0922686	REI1	YNL264C|PDR17|S000005208|Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
YNR071C	0.0916071	REI1	YNR071C||S000005354|Putative protein of unknown function
YMR298W	0.0911201	REI1	YMR298W|LIP1|S000004913|Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
YNL284C	0.0906416	REI1	YNL284C|MRPL10|S000005228|Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
YDR451C	0.0905119	REI1	YDR451C|YHP1|S000002859|One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YIL114C	0.0902677	REI1	YIL114C|POR2|S000001376|Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YGR190C	0.0901244	REI1	YGR190C||S000003422|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YGR123C	0.0892012	REI1	YGR123C|PPT1|S000003355|Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YIL004C	0.0890908	REI1	YIL004C|BET1|S000001266|Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YLL026W	0.0888577	REI1	YLL026W|HSP104|S000003949|Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YIL127C	0.0884218	REI1	YIL127C||S000001389|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YPL250W-A	0.0883838	REI1	YPL250W-A||S000028589|Identified by fungal homology and RT-PCR
YOR351C	0.0880891	REI1	YOR351C|MEK1|S000005878|Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
YNR055C	0.0876173	REI1	YNR055C|HOL1|S000005338|Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
YKL143W	0.087374	REI1	YKL143W|LTV1|S000001626|Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YHR089C	0.0872104	REI1	YHR089C|GAR1|S000001131|Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YMR136W	0.0870717	REI1	YMR136W|GAT2|S000004744|Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YIL067C	0.0867837	REI1	YIL067C||S000001329|Uncharacterized protein of unknown function
YIL003W	0.0861491	REI1	YIL003W|CFD1|S000001265|Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
YPL126W	0.0861082	REI1	YPL126W|NAN1|S000006047|U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
YDL148C	0.0858965	REI1	YDL148C|NOP14|S000002307|Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YNL016W	0.0830362	REI1	YNL016W|PUB1|S000004961|Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YIL116W	0.0823153	REI1	YIL116W|HIS5|S000001378|Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YML009C	0.0817767	REI1	YML009C|MRPL39|S000004468|Mitochondrial ribosomal protein of the large subunit
YFR050C	0.0817277	REI1	YFR050C|PRE4|S000001946|Beta 7 subunit of the 20S proteasome
YLR178C	0.0815197	REI1	YLR178C|TFS1|S000004168|Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YLR112W	0.0815026	REI1	YLR112W||S000004102|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR039W	0.0806451	REI1	YPR039W||S000006243|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
YKL144C	0.0806095	REI1	YKL144C|RPC25|S000001627|RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
YDR203W	0.0797281	REI1	YDR203W||S000002611|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR041C	0.0796769	REI1	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YOR011W	0.0793282	REI1	YOR011W|AUS1|S000005537|Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YGR250C	0.0792417	REI1	YGR250C||S000003482|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR012C	0.0789415	REI1	YBR012C||S000000216|Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YPR158W	0.077916	REI1	YPR158W||S000006362|Putative protein of unknown function
YOR146W	0.0778636	REI1	YOR146W||S000005672|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YDR534C	0.0775501	REI1	YDR534C|FIT1|S000002942|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YFR003C	0.0768123	REI1	YFR003C|YPI1|S000001899|Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen
YJL039C	0.0760583	REI1	YJL039C|NUP192|S000003576|Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
YER007W	0.0757028	REI1	YER007W|PAC2|S000000809|Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
YDL132W	0.0750306	REI1	YDL132W|CDC53|S000002290|Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YDR510W	0.0749637	REI1	YDR510W|SMT3|S000002918|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YOR086C	0.0748645	REI1	YOR086C|TCB1|S000005612|Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YCL035C	0.0746776	REI1	YCL035C|GRX1|S000000540|Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YEL008W	0.0746405	REI1	YEL008W||S000000734|Hypothetical protein predicted to be involved in metabolism
YIL021W	0.0746379	REI1	YIL021W|RPB3|S000001283|RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YKL052C	0.0740217	REI1	YKL052C|ASK1|S000001535|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YDL112W	0.0733861	REI1	YDL112W|TRM3|S000002270|2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YKR014C	0.0729532	REI1	YKR014C|YPT52|S000001722|GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YBL029C-A	0.0727986	REI1	YBL029C-A||S000007591|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
YOL040C	0.0727334	REI1	YOL040C|RPS15|S000005400|Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YLR375W	0.0724532	REI1	YLR375W|STP3|S000004367|Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YKL213C	0.0722666	REI1	YKL213C|DOA1|S000001696|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
YKL164C	0.071309	REI1	YKL164C|PIR1|S000001647|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YLR192C	0.0705559	REI1	YLR192C|HCR1|S000004182|Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
YKR027W	0.0703852	REI1	YKR027W|BCH2|S000001735|Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YOR352W	0.0703003	REI1	YOR352W||S000005879|Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR008C	0.0702348	REI1	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL215C	0.0698699	REI1	YKL215C||S000001698|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YIL064W	0.0691941	REI1	YIL064W||S000001326|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
YPR182W	0.0687288	REI1	YPR182W|SMX3|S000006386|Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
YGL239C	0.0677221	REI1	YGL239C||S000003208|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1
YKL120W	0.0677103	REI1	YKL120W|OAC1|S000001603|Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YIL058W	0.0662852	REI1	YIL058W||S000001320|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL211C	0.0661978	REI1	YJL211C||S000003747|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
YJL016W	0.0659113	REI1	YJL016W||S000003553|Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
YNL208W	0.0649203	REI1	YNL208W||S000005152|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi
YDR040C	0.0642301	REI1	YDR040C|ENA1|S000002447|P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YPL112C	0.0638201	REI1	YPL112C|PEX25|S000006033|Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YMR079W	0.0634376	REI1	YMR079W|SEC14|S000004684|Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs
YIL166C	0.0628339	REI1	YIL166C||S000001428|Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YOR105W	0.0626339	REI1	YOR105W||S000005631|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR199W	0.0624475	REI1	YBR199W|KTR4|S000000403|Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YFR032C-A	0.0620214	REI1	YFR032C-A|RPL29|S000006437|Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
YMR087W	0.0619389	REI1	YMR087W||S000004693|Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
YJR147W	0.061919	REI1	YJR147W|HMS2|S000003908|Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YKL223W	0.0618846	REI1	YKL223W||S000001706|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL012W	0.061738	REI1	YIL012W||S000001274|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR201C	0.060978	REI1	YLR201C|COQ9|S000004191|Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
YPL082C	0.060173	REI1	YPL082C|MOT1|S000006003|Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
YIR007W	0.0600975	REI1	YIR007W||S000001446|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YKL149C	0.0600221	REI1	YKL149C|DBR1|S000001632|RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
YCR102C	0.0586549	REI1	YCR102C||S000000699|Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YCL034W	0.0579373	REI1	YCL034W|LSB5|S000000539|Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YJL210W	0.0578149	REI1	YJL210W|PEX2|S000003746|RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
YER118C	0.0575543	REI1	YER118C|SHO1|S000000920|Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YDR202C	0.0575494	REI1	YDR202C|RAV2|S000002610|Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
YNL008C	0.0569566	REI1	YNL008C|ASI3|S000004953|Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YPL136W	0.0560063	REI1	YPL136W||S000006057|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
YJL187C	0.0558189	REI1	YJL187C|SWE1|S000003723|Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YPL111W	0.0550868	REI1	YPL111W|CAR1|S000006032|Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YDR204W	0.054735	REI1	YDR204W|COQ4|S000002612|Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
YHR172W	0.0543782	REI1	YHR172W|SPC97|S000001215|Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YNR060W	0.053961	REI1	YNR060W|FRE4|S000005343|Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YJL128C	0.0528499	REI1	YJL128C|PBS2|S000003664|MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition
YOR314W	0.0527461	REI1	YOR314W||S000005841|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL224C	0.0522379	REI1	YKL224C|PAU16|S000001707|Putative protein of unknown function
YDR337W	0.0517414	REI1	YDR337W|MRPS28|S000002745|Mitochondrial ribosomal protein of the small subunit
YDR155C	0.0514043	REI1	YDR155C|CPR1|S000002562|Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YIL033C	0.0511057	REI1	YIL033C|BCY1|S000001295|Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YNR036C	0.0510744	REI1	YNR036C||S000005319|Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
YDL081C	0.050679	REI1	YDL081C|RPP1A|S000002239|Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
YLR329W	0.0503529	REI1	YLR329W|REC102|S000004321|Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
YHR180W	0.0500548	REI1	YHR180W||S000001223|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR023C	0.0497681	REI1	YBR023C|CHS3|S000000227|Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YPL250C	0.0497538	REI1	YPL250C|ICY2|S000006171|Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YBR082C	0.049641	REI1	YBR082C|UBC4|S000000286|Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YML074C	0.0474466	REI1	YML074C|FPR3|S000004539|Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YGL160W	0.0472837	REI1	YGL160W|AIM14|S000003128|Putative protein of unknown function; similar to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes, null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YLR380W	0.0470162	REI1	YLR380W|CSR1|S000004372|Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YKR042W	0.0466803	REI1	YKR042W|UTH1|S000001750|Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YHR203C	0.0460218	REI1	YHR203C|RPS4B|S000001246|Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YNL049C	0.0459787	REI1	YNL049C|SFB2|S000004994|Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy
YHL037C	0.0459777	REI1	YHL037C||S000001029|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML038C	0.0454927	REI1	YML038C|YMD8|S000004502|Putative nucleotide sugar transporter, has similarity to Vrg4p
YKR026C	0.0449663	REI1	YKR026C|GCN3|S000001734|Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YMR078C	0.0449233	REI1	YMR078C|CTF18|S000004683|Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
YJL106W	0.0448601	REI1	YJL106W|IME2|S000003642|Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YEL053C	0.0444634	REI1	YEL053C|MAK10|S000000779|Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YAL061W	0.04403	REI1	YAL061W|BDH2|S000000057|Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YMR222C	0.0437322	REI1	YMR222C|FSH2|S000004835|Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p
YLR250W	0.0436604	REI1	YLR250W|SSP120|S000004240|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR058C	0.0434474	REI1	YBR058C|UBP14|S000000262|Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
YDR506C	0.0434079	REI1	YDR506C||S000002914|Possible membrane-localized protein
YGR232W	0.0432185	REI1	YGR232W|NAS6|S000003464|Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6
YBR054W	0.0429622	REI1	YBR054W|YRO2|S000000258|Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YKR043C	0.0428512	REI1	YKR043C||S000001751|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YMR011W	0.0426795	REI1	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR398W	0.0424526	REI1	YDR398W|UTP5|S000002806|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YBL091C	0.0422409	REI1	YBL091C|MAP2|S000000187|Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
YLR182W	0.0420283	REI1	YLR182W|SWI6|S000004172|Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
YCR047W-A	0.0413323	REI1	YCR047W-A||S000028608|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YPR002C-A	0.0407547	REI1	YPR002C-A||S000007254|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12
YDR010C	0.040424	REI1	YDR010C||S000002417|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR100C	0.040092	REI1	YJR100C|AIM25|S000003861|Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation); similar to murine NOR1
YDL242W	0.0397523	REI1	YDL242W||S000002401|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR438C-A	0.0393825	REI1	YLR438C-A|LSM3|S000006434|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YPR070W	0.0393743	REI1	YPR070W|MED1|S000006274|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YDR476C	0.0388394	REI1	YDR476C||S000002884|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YLR453C	0.0383846	REI1	YLR453C|RIF2|S000004445|Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YJL162C	0.0380939	REI1	YJL162C|JJJ2|S000003698|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR121W	0.0380152	REI1	YJR121W|ATP2|S000003882|Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YBR053C	0.0378893	REI1	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YIL029C	0.0370019	REI1	YIL029C||S000001291|Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YFR020W	0.0367329	REI1	YFR020W||S000001916|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL186C	0.0365618	REI1	YGL186C|TPN1|S000003154|Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YDR088C	0.0362337	REI1	YDR088C|SLU7|S000002495|RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YPL249C-A	0.0360193	REI1	YPL249C-A|RPL36B|S000006438|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YJL200C	0.0359088	REI1	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YOL011W	0.0355445	REI1	YOL011W|PLB3|S000005371|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YER103W	0.0350576	REI1	YER103W|SSA4|S000000905|Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YFL053W	0.034756	REI1	YFL053W|DAK2|S000001841|Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YER123W	0.0344804	REI1	YER123W|YCK3|S000000925|Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p
YDL190C	0.0339815	REI1	YDL190C|UFD2|S000002349|Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
YOR061W	0.0337025	REI1	YOR061W|CKA2|S000005587|Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YJL122W	0.0334598	REI1	YJL122W|ALB1|S000003658|Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YDR241W	0.0333227	REI1	YDR241W|BUD26|S000002649|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YER034W	0.0323516	REI1	YER034W||S000000836|Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YOL157C	0.0322047	REI1	YOL157C||S000005517|Putative protein of unknown function
YBL085W	0.0321331	REI1	YBL085W|BOI1|S000000181|Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YPR086W	0.0321044	REI1	YPR086W|SUA7|S000006290|Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
YER188W	0.0313355	REI1	YER188W||S000000990|Hypothetical protein
YMR093W	0.0310304	REI1	YMR093W|UTP15|S000004699|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNL173C	0.030784	REI1	YNL173C|MDG1|S000005117|Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
YNL337W	0.0305002	REI1	YNL337W||S000005281|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR374W	0.0296467	REI1	YOR374W|ALD4|S000005901|Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YBL090W	0.0296397	REI1	YBL090W|MRP21|S000000186|Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YHR016C	0.0295389	REI1	YHR016C|YSC84|S000001058|Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p
YBL011W	0.029348	REI1	YBL011W|SCT1|S000000107|Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
YBL036C	0.0289667	REI1	YBL036C||S000000132|Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YHR086W	0.028868	REI1	YHR086W|NAM8|S000001128|RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YJL093C	0.028572	REI1	YJL093C|TOK1|S000003629|Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YHL039W	0.0283891	REI1	YHL039W||S000001031|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YFL029C	0.0280466	REI1	YFL029C|CAK1|S000001865|Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
YHR037W	0.0280184	REI1	YHR037W|PUT2|S000001079|Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
YKL189W	0.0273407	REI1	YKL189W|HYM1|S000001672|Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YJL140W	0.0271783	REI1	YJL140W|RPB4|S000003676|RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions
YLR274W	0.0270565	REI1	YLR274W|MCM5|S000004264|Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YLR163C	0.0269483	REI1	YLR163C|MAS1|S000004153|Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YER159C	0.0261296	REI1	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YHR050W	0.0257194	REI1	YHR050W|SMF2|S000001092|Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YOL152W	0.0250059	REI1	YOL152W|FRE7|S000005512|Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YKR035W-A	0.0249133	REI1	YKR035W-A|DID2|S000006435|Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
YBR002C	0.0245248	REI1	YBR002C|RER2|S000000206|Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YCR081W	0.0241787	REI1	YCR081W|SRB8|S000000677|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
YGR231C	0.0241598	REI1	YGR231C|PHB2|S000003463|Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YER052C	0.0237027	REI1	YER052C|HOM3|S000000854|Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YDL147W	0.0234054	REI1	YDL147W|RPN5|S000002306|Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
YLR374C	0.0224911	REI1	YLR374C||S000004366|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YPL137C	0.0222172	REI1	YPL137C|GIP3|S000006058|Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YOR246C	0.0217092	REI1	YOR246C||S000005772|Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YMR041C	0.0216319	REI1	YMR041C|ARA2|S000004644|NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase
YLR185W	0.0213104	REI1	YLR185W|RPL37A|S000004175|Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YDR240C	0.0210332	REI1	YDR240C|SNU56|S000002648|Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YDR017C	0.0199491	REI1	YDR017C|KCS1|S000002424|Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
YJL078C	0.0196501	REI1	YJL078C|PRY3|S000003614|Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins
YER153C	0.0189183	REI1	YER153C|PET122|S000000955|Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
YDR357C	0.0181908	REI1	YDR357C||S000002765|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR058C-A	0.0176501	REI1	YBR058C-A|TSC3|S000007521|Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YHL026C	0.0169737	REI1	YHL026C||S000001018|Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YCR048W	0.0166485	REI1	YCR048W|ARE1|S000000644|Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen
YDR208W	0.0165731	REI1	YDR208W|MSS4|S000002616|Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
YLR191W	0.0163304	REI1	YLR191W|PEX13|S000004181|Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YNL071W	0.0161471	REI1	YNL071W|LAT1|S000005015|Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
YJL064W	0.0161431	REI1	YJL064W||S000003600|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
YBL058W	0.0157962	REI1	YBL058W|SHP1|S000000154|UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
YDR007W	0.0146801	REI1	YDR007W|TRP1|S000002414|Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YOR274W	0.0143417	REI1	YOR274W|MOD5|S000005800|Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YHR199C	0.0139276	REI1	YHR199C|AIM46|S000001242|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDR403W	0.0130899	REI1	YDR403W|DIT1|S000002811|Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
YMR223W	0.0126304	REI1	YMR223W|UBP8|S000004836|Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
YHR081W	0.0125505	REI1	YHR081W|LRP1|S000001123|Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YIL028W	0.0123422	REI1	YIL028W||S000001290|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL085W	0.0118551	REI1	YGL085W||S000003053|Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YML110C	0.0112731	REI1	YML110C|COQ5|S000004578|2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YKR090W	0.0109813	REI1	YKR090W|PXL1|S000001798|LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
YOR010C	0.0102238	REI1	YOR010C|TIR2|S000005536|Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YOR107W	0.00996294	REI1	YOR107W|RGS2|S000005633|Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YBR044C	0.00987764	REI1	YBR044C|TCM62|S000000248|Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YER006C-A	0.00977083	REI1	YER006C-A||S000028745|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2
YNL306W	0.00883093	REI1	YNL306W|MRPS18|S000005250|Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
YIL106W	0.00875375	REI1	YIL106W|MOB1|S000001368|Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
YCR084C	0.00787452	REI1	YCR084C|TUP1|S000000680|General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
YKL030W	0.00785968	REI1	YKL030W||S000001513|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
YNL285W	0.0078256	REI1	YNL285W||S000005229|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL086C	0.00779585	REI1	YBL086C||S000000182|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YFL017W-A	0.00766285	REI1	YFL017W-A|SMX2|S000002965|Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
YJR080C	0.00719711	REI1	YJR080C|AIM24|S000003841|Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media
YKL063C	0.00679461	REI1	YKL063C||S000001546|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YJL199C	0.00622541	REI1	YJL199C|MBB1|S000003735|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YHR038W	0.00618982	REI1	YHR038W|RRF1|S000001080|Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YCR049C	0.00608235	REI1	YCR049C||S000000645|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL026C	0.00580225	REI1	YAL026C|DRS2|S000000024|Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
YMR086C-A	0.00575062	REI1	YMR086C-A||S000004691|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR251W	0.00473675	REI1	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YGR235C	0.00457629	REI1	YGR235C||S000003467|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR373C	0.00448718	REI1	YLR373C|VID22|S000004365|Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
YGR099W	0.00400317	REI1	YGR099W|TEL2|S000003331|Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect
YLL053C	0.00385866	REI1	YLL053C||S000003976|Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YML117W	0.00338904	REI1	YML117W|NAB6|S000004585|Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data
YMR145C	0.00322923	REI1	YMR145C|NDE1|S000004753|Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YML016C	0.00269707	REI1	YML016C|PPZ1|S000004478|Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YNR033W	0.00252169	REI1	YNR033W|ABZ1|S000005316|Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB
YOL109W	0.00231072	REI1	YOL109W|ZEO1|S000005469|Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
YLR353W	0.00196434	REI1	YLR353W|BUD8|S000004345|Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YKR044W	0.00154608	REI1	YKR044W|UIP5|S000001752|Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
YOR376W	0.00128993	REI1	YOR376W||S000005903|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YJL198W	0.00128392	REI1	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YNL020C	0.000967586	REI1	YNL020C|ARK1|S000004965|Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis
YLR361C	0.000702718	REI1	YLR361C|DCR2|S000004353|Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
YJL024C	0.000671522	REI1	YJL024C|APS3|S000003561|Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function
