YGL255W	3.28643	SRD1	YGL255W|ZRT1|S000003224|High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YJR146W	1.7628	SRD1	YJR146W||S000003907|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YKL217W	1.67446	SRD1	YKL217W|JEN1|S000001700|Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YEL070W	1.56308	SRD1	YEL070W|DSF1|S000000796|Deletion suppressor of mpt5 mutation
YFR053C	1.5509	SRD1	YFR053C|HXK1|S000001949|Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YFL052W	1.42963	SRD1	YFL052W||S000001842|Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YKR097W	1.38526	SRD1	YKR097W|PCK1|S000001805|Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YOR343C	1.16895	SRD1	YOR343C||S000005870|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJR147W	1.11781	SRD1	YJR147W|HMS2|S000003908|Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YOR348C	1.05269	SRD1	YOR348C|PUT4|S000005875|Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YGR191W	0.996626	SRD1	YGR191W|HIP1|S000003423|High-affinity histidine permease, also involved in the transport of manganese ions
YJR077C	0.987839	SRD1	YJR077C|MIR1|S000003838|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YJL045W	0.974375	SRD1	YJL045W||S000003581|Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOL154W	0.893339	SRD1	YOL154W|ZPS1|S000005514|Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YGR190C	0.880928	SRD1	YGR190C||S000003422|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YHL021C	0.868673	SRD1	YHL021C|AIM17|S000001013|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YJR078W	0.867023	SRD1	YJR078W|BNA2|S000003839|Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YIL057C	0.866478	SRD1	YIL057C||S000001319|Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YLR375W	0.858405	SRD1	YLR375W|STP3|S000004367|Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YPR027C	0.852029	SRD1	YPR027C||S000006231|Putative protein of unknown function
YEL039C	0.827966	SRD1	YEL039C|CYC7|S000000765|Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YBR085C-A	0.808925	SRD1	YBR085C-A||S000007522|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YLR374C	0.796782	SRD1	YLR374C||S000004366|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YDR453C	0.793678	SRD1	YDR453C|TSA2|S000002861|Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YIR027C	0.792554	SRD1	YIR027C|DAL1|S000001466|Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YNL052W	0.779027	SRD1	YNL052W|COX5A|S000004997|Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YER150W	0.764483	SRD1	YER150W|SPI1|S000000952|GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YMR316C-B	0.758742	SRD1	YMR316C-B||S000004934|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML128C	0.746519	SRD1	YML128C|MSC1|S000004597|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YDR536W	0.745276	SRD1	YDR536W|STL1|S000002944|Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YGL258W-A	0.738566	SRD1	YGL258W-A||S000007607|Putative protein of unknown function
YHR139C	0.731871	SRD1	YHR139C|SPS100|S000001181|Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YGL055W	0.717298	SRD1	YGL055W|OLE1|S000003023|Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YLR203C	0.708814	SRD1	YLR203C|MSS51|S000004193|Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein
YIL037C	0.706236	SRD1	YIL037C|PRM2|S000001299|Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YFR017C	0.690022	SRD1	YFR017C||S000001913|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YNR034W-A	0.679974	SRD1	YNR034W-A||S000007525|Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YDR530C	0.677275	SRD1	YDR530C|APA2|S000002938|Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YIL059C	0.670626	SRD1	YIL059C||S000001321|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YBR145W	0.658725	SRD1	YBR145W|ADH5|S000000349|Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YGL162W	0.654213	SRD1	YGL162W|SUT1|S000003130|Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YMR317W	0.643569	SRD1	YMR317W||S000004936|Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YPL250C	0.604988	SRD1	YPL250C|ICY2|S000006171|Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YNR014W	0.596421	SRD1	YNR014W||S000005297|Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YER147C	0.592679	SRD1	YER147C|SCC4|S000000949|Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YPR028W	0.591658	SRD1	YPR028W|YOP1|S000006232|Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YJL093C	0.569951	SRD1	YJL093C|TOK1|S000003629|Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YBR035C	0.569824	SRD1	YBR035C|PDX3|S000000239|Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YMR319C	0.559144	SRD1	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YKL100C	0.550347	SRD1	YKL100C||S000001583|Putative protein of unknown function with similarity to a human minor histocompatibility antigen; YKL100C is not an essential gene
YHR140W	0.548944	SRD1	YHR140W||S000001182|Putative integral membrane protein of unknown function
YLR312C	0.546232	SRD1	YLR312C|QNQ1|S000004303|Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YHR177W	0.530127	SRD1	YHR177W||S000001220|Putative protein of unknown function
YGR279C	0.52609	SRD1	YGR279C|SCW4|S000003511|Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YEL008W	0.523304	SRD1	YEL008W||S000000734|Hypothetical protein predicted to be involved in metabolism
YBR132C	0.509675	SRD1	YBR132C|AGP2|S000000336|High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YER103W	0.506048	SRD1	YER103W|SSA4|S000000905|Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YPL054W	0.49292	SRD1	YPL054W|LEE1|S000005975|Zinc-finger protein of unknown function
YHR092C	0.489817	SRD1	YHR092C|HXT4|S000001134|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YPR198W	0.479223	SRD1	YPR198W|SGE1|S000006402|Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YEL009C	0.477992	SRD1	YEL009C|GCN4|S000000735|Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDL120W	0.470701	SRD1	YDL120W|YFH1|S000002278|Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia
YOR235W	0.465261	SRD1	YOR235W|IRC13|S000005761|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YML054C	0.463542	SRD1	YML054C|CYB2|S000004518|Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YPL224C	0.460172	SRD1	YPL224C|MMT2|S000006145|Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YJR148W	0.453823	SRD1	YJR148W|BAT2|S000003909|Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YPR197C	0.445003	SRD1	YPR197C||S000006401|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER065C	0.442368	SRD1	YER065C|ICL1|S000000867|Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YBR209W	0.43994	SRD1	YBR209W||S000000413|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YDR100W	0.434672	SRD1	YDR100W|TVP15|S000002507|Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YNR055C	0.430796	SRD1	YNR055C|HOL1|S000005338|Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
YER010C	0.428179	SRD1	YER010C||S000000812|Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YMR243C	0.42786	SRD1	YMR243C|ZRC1|S000004856|Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
YLR295C	0.426985	SRD1	YLR295C|ATP14|S000004286|Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YOR317W	0.425512	SRD1	YOR317W|FAA1|S000005844|Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YBL015W	0.424694	SRD1	YBL015W|ACH1|S000000111|Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YIL012W	0.423521	SRD1	YIL012W||S000001274|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR100C	0.41851	SRD1	YOR100C|CRC1|S000005626|Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YNL074C	0.413945	SRD1	YNL074C|MLF3|S000005018|Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YER141W	0.411074	SRD1	YER141W|COX15|S000000943|Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YNL125C	0.401724	SRD1	YNL125C|ESBP6|S000005069|Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YIL058W	0.401681	SRD1	YIL058W||S000001320|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR030W	0.399352	SRD1	YPR030W|CSR2|S000006234|Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YDL079C	0.398429	SRD1	YDL079C|MRK1|S000002237|Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YDR249C	0.397262	SRD1	YDR249C||S000002657|Putative protein of unknown function
YAL054C	0.386861	SRD1	YAL054C|ACS1|S000000050|Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YDR533C	0.38409	SRD1	YDR533C|HSP31|S000002941|Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YFL051C	0.382037	SRD1	YFL051C||S000001843|Putative protein of unknown function; YFL051C is not an essential gene
YNL144C	0.38166	SRD1	YNL144C||S000005088|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YNL036W	0.381096	SRD1	YNL036W|NCE103|S000004981|Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YGR248W	0.369242	SRD1	YGR248W|SOL4|S000003480|6-phosphogluconolactonase with similarity to Sol3p
YKR042W	0.368276	SRD1	YKR042W|UTH1|S000001750|Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YOL032W	0.366631	SRD1	YOL032W|OPI10|S000005392|Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
YMR155W	0.364911	SRD1	YMR155W||S000004764|Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
YHR086W	0.364879	SRD1	YHR086W|NAM8|S000001128|RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YOR142W	0.361661	SRD1	YOR142W|LSC1|S000005668|Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
YLR331C	0.360578	SRD1	YLR331C|JIP3|S000004323|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YOR149C	0.359821	SRD1	YOR149C|SMP3|S000005675|Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
YDR304C	0.35754	SRD1	YDR304C|CPR5|S000002712|Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
YPL223C	0.357416	SRD1	YPL223C|GRE1|S000006144|Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YOR298C-A	0.353938	SRD1	YOR298C-A|MBF1|S000007253|Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YPR061C	0.35332	SRD1	YPR061C|JID1|S000006265|Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YMR042W	0.349172	SRD1	YMR042W|ARG80|S000004645|Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
YER066W	0.347931	SRD1	YER066W||S000000868|Putative protein of unknown function; YER066W is not an essential gene
YOL082W	0.34747	SRD1	YOL082W|ATG19|S000005442|Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YLR311C	0.344706	SRD1	YLR311C||S000004302|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR022W	0.341272	SRD1	YMR022W|UBC7|S000004624|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
YGR043C	0.34007	SRD1	YGR043C|NQM1|S000003275|Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YLR332W	0.339719	SRD1	YLR332W|MID2|S000004324|O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YKL008C	0.338292	SRD1	YKL008C|LAC1|S000001491|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YGL053W	0.338118	SRD1	YGL053W|PRM8|S000003021|Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YPR013C	0.335739	SRD1	YPR013C||S000006217|Putative zinc finger protein; YPR013C is not an essential gene
YJR150C	0.33476	SRD1	YJR150C|DAN1|S000003911|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YGR268C	0.333654	SRD1	YGR268C|HUA1|S000003500|Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YJL067W	0.331251	SRD1	YJL067W||S000003603|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR210W	0.330634	SRD1	YMR210W||S000004823|Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YML123C	0.328565	SRD1	YML123C|PHO84|S000004592|High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YIL166C	0.328459	SRD1	YIL166C||S000001428|Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YPR160W	0.325172	SRD1	YPR160W|GPH1|S000006364|Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YDR250C	0.325093	SRD1	YDR250C||S000002658|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR152C	0.324588	SRD1	YOR152C||S000005678|Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YNL066W	0.324128	SRD1	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YNL160W	0.321189	SRD1	YNL160W|YGP1|S000005104|Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YPL262W	0.316562	SRD1	YPL262W|FUM1|S000006183|Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YLL051C	0.313592	SRD1	YLL051C|FRE6|S000003974|Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YDR124W	0.312483	SRD1	YDR124W||S000002531|Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YML100W	0.309908	SRD1	YML100W|TSL1|S000004566|Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YAR047C	0.309454	SRD1	YAR047C||S000000083|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR019C	0.308279	SRD1	YAR019C|CDC15|S000000072|Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YPL222W	0.304661	SRD1	YPL222W|FMP40|S000006143|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL052W	0.304281	SRD1	YEL052W|AFG1|S000000778|Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YGR068C	0.304001	SRD1	YGR068C||S000003300|Putative protein of unknown function; YGR068C is not an essential gene.
YNL037C	0.30285	SRD1	YNL037C|IDH1|S000004982|Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YLR228C	0.302155	SRD1	YLR228C|ECM22|S000004218|Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YDR406W	0.301537	SRD1	YDR406W|PDR15|S000002814|Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YJL217W	0.298026	SRD1	YJL217W||S000003753|Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YPR093C	0.296224	SRD1	YPR093C|ASR1|S000006297|Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain
YLR037C	0.296018	SRD1	YLR037C|DAN2|S000004027|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YGL114W	0.295118	SRD1	YGL114W||S000003082|Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YJL068C	0.294213	SRD1	YJL068C||S000003604|Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YJR001W	0.289368	SRD1	YJR001W|AVT1|S000003761|Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YIL047C	0.28777	SRD1	YIL047C|SYG1|S000001309|Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YMR306W	0.284729	SRD1	YMR306W|FKS3|S000004923|Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL162W	0.283848	SRD1	YIL162W|SUC2|S000001424|Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YDR277C	0.278104	SRD1	YDR277C|MTH1|S000002685|Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDR342C	0.270469	SRD1	YDR342C|HXT7|S000002750|High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YBR072W	0.269512	SRD1	YBR072W|HSP26|S000000276|Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOR316C-A	0.267758	SRD1	YOR316C-A||S000028584|Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL142C	0.267747	SRD1	YDL142C|CRD1|S000002301|Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function
YOL052C	0.266717	SRD1	YOL052C|SPE2|S000005412|S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YAR019W-A	0.265949	SRD1	YAR019W-A||S000028735|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL185C	0.264961	SRD1	YJL185C||S000003721|Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YAR027W	0.264107	SRD1	YAR027W|UIP3|S000000075|Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YLR122C	0.262489	SRD1	YLR122C||S000004112|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YHR078W	0.261831	SRD1	YHR078W||S000001120|High osmolarity-regulated gene of unknown function
YDR540C	0.254709	SRD1	YDR540C|IRC4|S000002948|Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR234W	0.254642	SRD1	YGR234W|YHB1|S000003466|Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YDR251W	0.254411	SRD1	YDR251W|PAM1|S000002659|Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YCR021C	0.252331	SRD1	YCR021C|HSP30|S000000615|Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YPR017C	0.250726	SRD1	YPR017C|DSS4|S000006221|Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YCL048W-A	0.249297	SRD1	YCL048W-A||S000087203|Putative protein of unknown function
YKL051W	0.245497	SRD1	YKL051W|SFK1|S000001534|Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YAR053W	0.245389	SRD1	YAR053W||S000000085|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR320W	0.244581	SRD1	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR077C	0.242507	SRD1	YBR077C|SLM4|S000000281|Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YBL047C	0.24191	SRD1	YBL047C|EDE1|S000000143|Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
YHR180W	0.239566	SRD1	YHR180W||S000001223|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR257C	0.239193	SRD1	YGR257C|MTM1|S000003489|Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
YML120C	0.237472	SRD1	YML120C|NDI1|S000004589|NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YDR009W	0.237446	SRD1	YDR009W|GAL3|S000002416|Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YAR060C	0.237365	SRD1	YAR060C||S000000086|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL192W	0.237336	SRD1	YGL192W|IME4|S000003160|Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YOR010C	0.236676	SRD1	YOR010C|TIR2|S000005536|Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YDR034C	0.233438	SRD1	YDR034C|LYS14|S000002441|Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YGR022C	0.233077	SRD1	YGR022C||S000003254|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YMR029C	0.233049	SRD1	YMR029C|FAR8|S000004631|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YKL044W	0.231748	SRD1	YKL044W||S000001527|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR131W	0.231569	SRD1	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YDL085W	0.230967	SRD1	YDL085W|NDE2|S000002243|Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YOL119C	0.230813	SRD1	YOL119C|MCH4|S000005479|Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YMR021C	0.230644	SRD1	YMR021C|MAC1|S000004623|Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YGR023W	0.229845	SRD1	YGR023W|MTL1|S000003255|Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YJR048W	0.229685	SRD1	YJR048W|CYC1|S000003809|Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YJL103C	0.228265	SRD1	YJL103C|GSM1|S000003639|Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YDR322W	0.227611	SRD1	YDR322W|MRPL35|S000002730|Mitochondrial ribosomal protein of the large subunit
YIL060W	0.22587	SRD1	YIL060W||S000001322|Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YMR135C	0.224754	SRD1	YMR135C|GID8|S000004742|Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YLR023C	0.222802	SRD1	YLR023C|IZH3|S000004013|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YIR020W-A	0.22202	SRD1	YIR020W-A||S000007241|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR176W	0.219661	SRD1	YOR176W|HEM15|S000005702|Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YKR066C	0.218627	SRD1	YKR066C|CCP1|S000001774|Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YDR173C	0.218349	SRD1	YDR173C|ARG82|S000002580|Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YOL030W	0.218337	SRD1	YOL030W|GAS5|S000005390|1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YOR273C	0.215055	SRD1	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YDL181W	0.214764	SRD1	YDL181W|INH1|S000002340|Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YHR109W	0.214228	SRD1	YHR109W|CTM1|S000001151|Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
YER179W	0.214106	SRD1	YER179W|DMC1|S000000981|Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein
YPL092W	0.213466	SRD1	YPL092W|SSU1|S000006013|Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YLR123C	0.213346	SRD1	YLR123C||S000004113|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR296W	0.212645	SRD1	YLR296W||S000004287|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR002W	0.212341	SRD1	YHR002W|LEU5|S000001044|Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized
YFR007W	0.21193	SRD1	YFR007W|YFH7|S000001903|Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YPR020W	0.211447	SRD1	YPR020W|ATP20|S000006224|Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YPL244C	0.20976	SRD1	YPL244C|HUT1|S000006165|Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
YPR010C-A	0.209478	SRD1	YPR010C-A||S000122558|Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YDR046C	0.209257	SRD1	YDR046C|BAP3|S000002453|Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YGL193C	0.208801	SRD1	YGL193C||S000003161|Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YLR366W	0.208071	SRD1	YLR366W||S000004358|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YOL128C	0.207667	SRD1	YOL128C|YGK3|S000005488|Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YDR322C-A	0.207255	SRD1	YDR322C-A|TIM11|S000007255|Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
YKL141W	0.207161	SRD1	YKL141W|SDH3|S000001624|Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YGR250C	0.205951	SRD1	YGR250C||S000003482|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPL113C	0.205713	SRD1	YPL113C||S000006034|Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
YGR041W	0.204289	SRD1	YGR041W|BUD9|S000003273|Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
YOR012W	0.203895	SRD1	YOR012W||S000005538|Putative protein of unknown function
YCL042W	0.203196	SRD1	YCL042W||S000000547|Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YMR206W	0.202999	SRD1	YMR206W||S000004819|Putative protein of unknown function; YMR206W is not an essential gene
YOR186W	0.200752	SRD1	YOR186W||S000005712|Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YAR050W	0.200186	SRD1	YAR050W|FLO1|S000000084|Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YMR139W	0.199096	SRD1	YMR139W|RIM11|S000004747|Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta
YJR107W	0.198859	SRD1	YJR107W||S000003868|Putative protein of unknown function; has sequence or structural similarity to lipases
YLR142W	0.198734	SRD1	YLR142W|PUT1|S000004132|Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YER119C	0.196	SRD1	YER119C|AVT6|S000000921|Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YHR179W	0.195174	SRD1	YHR179W|OYE2|S000001222|Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YCL040W	0.194547	SRD1	YCL040W|GLK1|S000000545|Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YKR012C	0.194051	SRD1	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YNL073W	0.192772	SRD1	YNL073W|MSK1|S000005017|Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
YGR281W	0.192223	SRD1	YGR281W|YOR1|S000003513|Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
YGR107W	0.191992	SRD1	YGR107W||S000003339|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR041C	0.191017	SRD1	YMR041C|ARA2|S000004644|NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase
YOR072W	0.19048	SRD1	YOR072W||S000005598|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YKL043W	0.189286	SRD1	YKL043W|PHD1|S000001526|Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YML131W	0.1892	SRD1	YML131W||S000004600|Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YLR104W	0.18907	SRD1	YLR104W||S000004094|Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate
YJL121C	0.188658	SRD1	YJL121C|RPE1|S000003657|D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YEL012W	0.187696	SRD1	YEL012W|UBC8|S000000738|Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YIR020C	0.187552	SRD1	YIR020C||S000001459|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR188C	0.187359	SRD1	YMR188C|MRPS17|S000004800|Mitochondrial ribosomal protein of the small subunit
YOR381W	0.185182	SRD1	YOR381W|FRE3|S000005908|Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YER163C	0.184598	SRD1	YER163C||S000000965|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YAL048C	0.184344	SRD1	YAL048C|GEM1|S000000046|Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death
YFL039C	0.182905	SRD1	YFL039C|ACT1|S000001855|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YAR023C	0.180625	SRD1	YAR023C||S000000074|Putative integral membrane protein, member of DUP240 gene family
YJL151C	0.180098	SRD1	YJL151C|SNA3|S000003687|Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YGR042W	0.179697	SRD1	YGR042W||S000003274|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YDR309C	0.179601	SRD1	YDR309C|GIC2|S000002717|Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YJR151C	0.179459	SRD1	YJR151C|DAN4|S000003912|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YJL056C	0.178559	SRD1	YJL056C|ZAP1|S000003592|Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains
YMR305C	0.177998	SRD1	YMR305C|SCW10|S000004921|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YOR192C	0.177261	SRD1	YOR192C|THI72|S000005718|Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YPL015C	0.176917	SRD1	YPL015C|HST2|S000005936|Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YOR072W-A	0.176323	SRD1	YOR072W-A||S000028582|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YER186C	0.175284	SRD1	YER186C||S000000988|Putative protein of unknown function
YKR044W	0.173993	SRD1	YKR044W|UIP5|S000001752|Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
YDR186C	0.17308	SRD1	YDR186C||S000002594|Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR131C	0.172672	SRD1	YLR131C|ACE2|S000004121|Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate
YOR071C	0.172458	SRD1	YOR071C|NRT1|S000005597|High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YOR150W	0.169808	SRD1	YOR150W|MRPL23|S000005676|Mitochondrial ribosomal protein of the large subunit
YGL088W	0.16859	SRD1	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YGL205W	0.168157	SRD1	YGL205W|POX1|S000003173|Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YDR185C	0.168114	SRD1	YDR185C||S000002593|Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YPL162C	0.167471	SRD1	YPL162C||S000006083|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
YGL007W	0.167237	SRD1	YGL007W|BRP1|S000002975|Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
YBR013C	0.167112	SRD1	YBR013C||S000000217|Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein
YLR110C	0.166617	SRD1	YLR110C|CCW12|S000004100|Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLR395C	0.166564	SRD1	YLR395C|COX8|S000004387|Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YPL156C	0.16596	SRD1	YPL156C|PRM4|S000006077|Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YHR212C	0.165936	SRD1	YHR212C||S000001255|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER158C	0.165126	SRD1	YER158C||S000000960|Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YPL126W	0.164865	SRD1	YPL126W|NAN1|S000006047|U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
YKL031W	0.164849	SRD1	YKL031W||S000001514|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YDR093W	0.164477	SRD1	YDR093W|DNF2|S000002500|Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YLR279W	0.16444	SRD1	YLR279W||S000004269|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL246C	0.16268	SRD1	YPL246C|RBD2|S000006167|Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
YGR182C	0.162552	SRD1	YGR182C||S000003414|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
YBL020W	0.160333	SRD1	YBL020W|RFT1|S000000116|Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein
YOL020W	0.158255	SRD1	YOL020W|TAT2|S000005380|High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YGL161C	0.158238	SRD1	YGL161C|YIP5|S000003129|Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YOL118C	0.157949	SRD1	YOL118C||S000005478|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPR146C	0.157644	SRD1	YPR146C||S000006350|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL043W	0.157024	SRD1	YBL043W|ECM13|S000000139|Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGL258W	0.156412	SRD1	YGL258W|VEL1|S000003227|Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YPL014W	0.156367	SRD1	YPL014W||S000005935|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YML122C	0.155753	SRD1	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL044W	0.155719	SRD1	YHL044W||S000001036|Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
YBR076W	0.155605	SRD1	YBR076W|ECM8|S000000280|Non-essential protein of unknown function
YAL047W-A	0.155331	SRD1	YAL047W-A||S000028733|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR228C	0.153969	SRD1	YOR228C||S000005754|Protein of unknown function, localized to the mitochondrial outer membrane
YGR136W	0.153848	SRD1	YGR136W|LSB1|S000003368|Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YKL170W	0.153795	SRD1	YKL170W|MRPL38|S000001653|Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
YPR011C	0.153675	SRD1	YPR011C||S000006215|Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR248W	0.15206	SRD1	YLR248W|RCK2|S000004238|Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YIL090W	0.151834	SRD1	YIL090W|ICE2|S000001352|Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells
YGL008C	0.151795	SRD1	YGL008C|PMA1|S000002976|Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases
YGL166W	0.149776	SRD1	YGL166W|CUP2|S000003134|Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
YJL130C	0.148629	SRD1	YJL130C|URA2|S000003666|Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YEL017W	0.148238	SRD1	YEL017W|GTT3|S000000743|Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YJL102W	0.148216	SRD1	YJL102W|MEF2|S000003638|Mitochondrial elongation factor involved in translational elongation
YOR382W	0.147952	SRD1	YOR382W|FIT2|S000005909|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGR197C	0.147675	SRD1	YGR197C|SNG1|S000003429|Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YNR073C	0.144936	SRD1	YNR073C||S000005356|Putative mannitol dehydrogenase
YIL046W-A	0.143725	SRD1	YIL046W-A||S000028836|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YPR117W	0.142794	SRD1	YPR117W||S000006321|Putative protein of unknown function
YKR013W	0.139651	SRD1	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YMR244W	0.139109	SRD1	YMR244W||S000004858|Putative protein of unknown function
YIL102C	0.13781	SRD1	YIL102C||S000001364|Putative protein of unknown function
YER133W-A	0.137778	SRD1	YER133W-A||S000028756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YHR211W	0.137003	SRD1	YHR211W|FLO5|S000001254|Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YBR241C	0.134896	SRD1	YBR241C||S000000445|Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YJL052W	0.13465	SRD1	YJL052W|TDH1|S000003588|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YNL176C	0.132546	SRD1	YNL176C||S000005120|Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YDR317W	0.132368	SRD1	YDR317W|HIM1|S000002725|Protein of unknown function involved in DNA repair
YLR297W	0.131492	SRD1	YLR297W||S000004288|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YNL142W	0.131061	SRD1	YNL142W|MEP2|S000005086|Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YEL038W	0.130559	SRD1	YEL038W|UTR4|S000000764|Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus
YBL049W	0.130208	SRD1	YBL049W|MOH1|S000000145|Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YCR005C	0.130177	SRD1	YCR005C|CIT2|S000000598|Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YLR125W	0.129853	SRD1	YLR125W||S000004115|Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YGL028C	0.12936	SRD1	YGL028C|SCW11|S000002996|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YAL020C	0.129073	SRD1	YAL020C|ATS1|S000000018|Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
YBL030C	0.128892	SRD1	YBL030C|PET9|S000000126|Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YBL082C	0.128603	SRD1	YBL082C|ALG3|S000000178|Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
YDR119W-A	0.128385	SRD1	YDR119W-A||S000113555|Putative protein of unknown function
YIL100C-A	0.127547	SRD1	YIL100C-A||S000028794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR096C	0.127228	SRD1	YHR096C|HXT5|S000001138|Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YLL019C	0.127047	SRD1	YLL019C|KNS1|S000003942|Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YLL026W	0.126642	SRD1	YLL026W|HSP104|S000003949|Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YMR148W	0.126251	SRD1	YMR148W||S000004756|Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene
YFR047C	0.125908	SRD1	YFR047C|BNA6|S000001943|Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YOR366W	0.125478	SRD1	YOR366W||S000005893|Hypothetical protein
YLR342W	0.125026	SRD1	YLR342W|FKS1|S000004334|Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YGL052W	0.124087	SRD1	YGL052W||S000003020|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27
YDL095W	0.123706	SRD1	YDL095W|PMT1|S000002253|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals
YMR090W	0.122621	SRD1	YMR090W||S000004696|Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YHR049W	0.122298	SRD1	YHR049W|FSH1|S000001091|Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p
YGR244C	0.121214	SRD1	YGR244C|LSC2|S000003476|Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YGL140C	0.121209	SRD1	YGL140C||S000003108|Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YMR020W	0.120852	SRD1	YMR020W|FMS1|S000004622|Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
YEL011W	0.120184	SRD1	YEL011W|GLC3|S000000737|Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL002W	0.119951	SRD1	YGL002W|ERP6|S000002970|Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL137C	0.119585	SRD1	YNL137C|NAM9|S000005081|Mitochondrial ribosomal component of the small subunit
YAL019W-A	0.118367	SRD1	YAL019W-A||S000028729|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL199C	0.118281	SRD1	YJL199C|MBB1|S000003735|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YMR007W	0.118107	SRD1	YMR007W||S000004609|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL024W	0.117448	SRD1	YPL024W|RMI1|S000005945|Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YHL043W	0.117145	SRD1	YHL043W|ECM34|S000001035|Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YDR175C	0.117074	SRD1	YDR175C|RSM24|S000002582|Mitochondrial ribosomal protein of the small subunit
YIL145C	0.116853	SRD1	YIL145C|PAN6|S000001407|Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YBR269C	0.116503	SRD1	YBR269C|FMP21|S000000473|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR350C	0.116225	SRD1	YDR350C|ATP22|S000002758|Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YKL207W	0.116053	SRD1	YKL207W|LRC3|S000001690|Putative protein of unknown function; non-essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YBR096W	0.11504	SRD1	YBR096W||S000000300|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YOR099W	0.114972	SRD1	YOR099W|KTR1|S000005625|Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YJR095W	0.113105	SRD1	YJR095W|SFC1|S000003856|Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YHR124W	0.112906	SRD1	YHR124W|NDT80|S000001166|Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YMR154C	0.112874	SRD1	YMR154C|RIM13|S000004763|Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB
YGL119W	0.111317	SRD1	YGL119W|ABC1|S000003087|Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis
YJR080C	0.111025	SRD1	YJR080C|AIM24|S000003841|Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media
YPR042C	0.110595	SRD1	YPR042C|PUF2|S000006246|Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
YGR149W	0.110505	SRD1	YGR149W||S000003381|Putative protein of unknown function; predicted to be an integal membrane protein
YCR023C	0.110214	SRD1	YCR023C||S000000617|Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
YJL104W	0.107715	SRD1	YJL104W|PAM16|S000003640|Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain
YBR213W	0.107711	SRD1	YBR213W|MET8|S000000417|Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YOR236W	0.107428	SRD1	YOR236W|DFR1|S000005762|Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YLR373C	0.107018	SRD1	YLR373C|VID22|S000004365|Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
YDL224C	0.106545	SRD1	YDL224C|WHI4|S000002383|Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YHR202W	0.106457	SRD1	YHR202W||S000001245|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YCR010C	0.106259	SRD1	YCR010C|ADY2|S000000603|Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YOR192C-C	0.105942	SRD1	YOR192C-C||S000028857|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YMR280C	0.105731	SRD1	YMR280C|CAT8|S000004893|Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YLR286C	0.105448	SRD1	YLR286C|CTS1|S000004276|Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YDR541C	0.105269	SRD1	YDR541C||S000002949|Putative dihydrokaempferol 4-reductase
YGR106C	0.105202	SRD1	YGR106C|VOA1|S000003338|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YPR062W	0.105171	SRD1	YPR062W|FCY1|S000006266|Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YJL048C	0.10474	SRD1	YJL048C|UBX6|S000003584|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YJL172W	0.104528	SRD1	YJL172W|CPS1|S000003708|Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YEL047C	0.104156	SRD1	YEL047C||S000000773|Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YDR018C	0.103811	SRD1	YDR018C||S000002425|Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YGR288W	0.103788	SRD1	YGR288W|MAL13|S000003520|MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YKR067W	0.103339	SRD1	YKR067W|GPT2|S000001775|Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YKL033W-A	0.102354	SRD1	YKL033W-A||S000007242|Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YPL271W	0.102152	SRD1	YPL271W|ATP15|S000006192|Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YBR067C	0.102117	SRD1	YBR067C|TIP1|S000000271|Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YJL057C	0.101876	SRD1	YJL057C|IKS1|S000003593|Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
YFL030W	0.101479	SRD1	YFL030W|AGX1|S000001864|Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YGL188C	0.101442	SRD1	YGL188C||S000003156|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR110W	0.101189	SRD1	YGR110W||S000003342|Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YHR139C-A	0.101061	SRD1	YHR139C-A||S000003533|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL122W	0.101002	SRD1	YIL122W|POG1|S000001384|Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YLR113W	0.100957	SRD1	YLR113W|HOG1|S000004103|Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YBL099W	0.100941	SRD1	YBL099W|ATP1|S000000195|Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOR175C	0.100565	SRD1	YOR175C|ALE1|S000005701|Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
YLR028C	0.100487	SRD1	YLR028C|ADE16|S000004018|Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YBR053C	0.100214	SRD1	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YBR220C	0.100101	SRD1	YBR220C||S000000424|Putative protein of unknown function; YBR220C is not an essential gene
YGL051W	0.0977386	SRD1	YGL051W|MST27|S000003019|Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
YBL016W	0.0976483	SRD1	YBL016W|FUS3|S000000112|Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
YNR036C	0.0975617	SRD1	YNR036C||S000005319|Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
YCL049C	0.097412	SRD1	YCL049C||S000000554|Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YGR213C	0.0968883	SRD1	YGR213C|RTA1|S000003445|Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YOR311C	0.0964339	SRD1	YOR311C|DGK1|S000005838|Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
YBR201C-A	0.096344	SRD1	YBR201C-A||S000087085|Putative protein of unknown function
YKR009C	0.0963292	SRD1	YKR009C|FOX2|S000001717|Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YDR059C	0.0961091	SRD1	YDR059C|UBC5|S000002466|Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YHR104W	0.0956771	SRD1	YHR104W|GRE3|S000001146|Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YIL043C	0.0954691	SRD1	YIL043C|CBR1|S000001305|Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
YKL178C	0.0954667	SRD1	YKL178C|STE3|S000001661|Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YNL093W	0.0948472	SRD1	YNL093W|YPT53|S000005037|GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YAL039C	0.0942504	SRD1	YAL039C|CYC3|S000000037|Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YKL185W	0.0941152	SRD1	YKL185W|ASH1|S000001668|Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YJR004C	0.0940819	SRD1	YJR004C|SAG1|S000003764|Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YOR387C	0.0936991	SRD1	YOR387C||S000005914|Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YNL055C	0.0936562	SRD1	YNL055C|POR1|S000005000|Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YPR106W	0.0926983	SRD1	YPR106W|ISR1|S000006310|Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
YFR021W	0.0926165	SRD1	YFR021W|ATG18|S000001917|Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
YPL109C	0.0925744	SRD1	YPL109C||S000006030|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL021C	0.0918331	SRD1	YBL021C|HAP3|S000000117|Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
YGR143W	0.0913927	SRD1	YGR143W|SKN1|S000003375|Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
YER068C-A	0.0908378	SRD1	YER068C-A||S000028749|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL117C	0.0900189	SRD1	YPL117C|IDI1|S000006038|Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
YOR365C	0.0899552	SRD1	YOR365C||S000005892|Putative protein of unknown function; YOR365C is not an essential protein
YOR377W	0.0899527	SRD1	YOR377W|ATF1|S000005904|Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation
YHR126C	0.0894042	SRD1	YHR126C||S000001168|Putative protein of unknown function; transcription dependent upon Azf1p
YLR377C	0.0890073	SRD1	YLR377C|FBP1|S000004369|Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YGL056C	0.0887307	SRD1	YGL056C|SDS23|S000003024|One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YMR017W	0.088724	SRD1	YMR017W|SPO20|S000004619|Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YLR124W	0.0886685	SRD1	YLR124W||S000004114|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR212W-A	0.088441	SRD1	YHR212W-A||S000028650|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL040C	0.087975	SRD1	YPL040C|ISM1|S000005961|Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
YBL017C	0.0877747	SRD1	YBL017C|PEP1|S000000113|Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YDR542W	0.0876879	SRD1	YDR542W|PAU10|S000002950|Hypothetical protein
YIL083C	0.0874731	SRD1	YIL083C||S000001345|Putative phosphopantothenoylcysteine synthetase (PPCS) that catalyzes the second step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability
YIL082W	0.087325	SRD1	YIL082W||S000001344|Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
YIL146C	0.0868777	SRD1	YIL146C|ECM37|S000001408|Non-essential protein of unknown function
YKL177W	0.0857471	SRD1	YKL177W||S000001660|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YGL187C	0.0857186	SRD1	YGL187C|COX4|S000003155|Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YGR260W	0.0851533	SRD1	YGR260W|TNA1|S000003492|High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YDR391C	0.0851009	SRD1	YDR391C||S000002799|Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR066W	0.0846461	SRD1	YOR066W|MSA1|S000005592|Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YIL113W	0.0845848	SRD1	YIL113W|SDP1|S000001375|Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YOR075W	0.0842535	SRD1	YOR075W|UFE1|S000005601|t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex
YBL086C	0.0842454	SRD1	YBL086C||S000000182|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YHR136C	0.0838685	SRD1	YHR136C|SPL2|S000001178|Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL315C	0.0838025	SRD1	YNL315C|ATP11|S000005259|Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YMR302C	0.0835121	SRD1	YMR302C|YME2|S000004917|Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
YGL015C	0.0828404	SRD1	YGL015C||S000002983|Hypothetical protein
YNL077W	0.0825313	SRD1	YNL077W|APJ1|S000005021|Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR349C	0.0824046	SRD1	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YOR245C	0.0823634	SRD1	YOR245C|DGA1|S000005771|Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
YGL054C	0.0818138	SRD1	YGL054C|ERV14|S000003022|Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
YDR535C	0.0817997	SRD1	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YDL186W	0.0809153	SRD1	YDL186W||S000002345|Putative protein of unknown function; YDL186W is not an essential gene
YDR022C	0.0807179	SRD1	YDR022C|CIS1|S000002429|Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YLR387C	0.0802291	SRD1	YLR387C|REH1|S000004379|Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains
YER053C	0.079469	SRD1	YER053C|PIC2|S000000855|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YPL257W	0.0792633	SRD1	YPL257W||S000006178|Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YPL183W-A	0.0790566	SRD1	YPL183W-A|RTC6|S000007224|Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YBR125C	0.0790549	SRD1	YBR125C|PTC4|S000000329|Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
YDL130W-A	0.078374	SRD1	YDL130W-A|STF1|S000007232|Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YBR185C	0.0781391	SRD1	YBR185C|MBA1|S000000389|Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane
YIL099W	0.0774408	SRD1	YIL099W|SGA1|S000001361|Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YMR265C	0.0774092	SRD1	YMR265C||S000004878|Putative protein of unknown function
YJL058C	0.0773498	SRD1	YJL058C|BIT61|S000003594|Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity
YOR011W	0.0761157	SRD1	YOR011W|AUS1|S000005537|Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YHL032C	0.0760176	SRD1	YHL032C|GUT1|S000001024|Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YER026C	0.0758823	SRD1	YER026C|CHO1|S000000828|Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YJL166W	0.0756375	SRD1	YJL166W|QCR8|S000003702|Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YDL113C	0.0755958	SRD1	YDL113C|ATG20|S000002271|Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YLR135W	0.0752427	SRD1	YLR135W|SLX4|S000004125|Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YDR125C	0.0750606	SRD1	YDR125C|ECM18|S000002532|Protein of unknown function, similar to Rlp24p
YER069W	0.0741817	SRD1	YER069W|ARG5,6|S000000871|Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YOL106W	0.0735996	SRD1	YOL106W||S000005466|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YIL051C	0.0735801	SRD1	YIL051C|MMF1|S000001313|Mitochondrial protein involved in maintenance of the mitochondrial genome
YGR269W	0.0734032	SRD1	YGR269W||S000003501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
YDR225W	0.0733346	SRD1	YDR225W|HTA1|S000002633|One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YBR054W	0.0729277	SRD1	YBR054W|YRO2|S000000258|Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YKL037W	0.0728556	SRD1	YKL037W|AIM26|S000001520|Putative protein of unknown function; null mutant is viable and displays increased frequency of mitochondrial genome loss (petite formation)
YHR176W	0.0727436	SRD1	YHR176W|FMO1|S000001219|Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YGL194C	0.0717125	SRD1	YGL194C|HOS2|S000003162|Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YBR095C	0.0706974	SRD1	YBR095C|RXT2|S000000299|Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
YGR259C	0.0702465	SRD1	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YIL136W	0.0697416	SRD1	YIL136W|OM45|S000001398|Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YNL210W	0.0695469	SRD1	YNL210W|MER1|S000005154|Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination
YJL163C	0.0693978	SRD1	YJL163C||S000003699|Putative protein of unknown function
YNR001C	0.0693932	SRD1	YNR001C|CIT1|S000005284|Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YDR102C	0.0692289	SRD1	YDR102C||S000002509|Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YOR261C	0.0689992	SRD1	YOR261C|RPN8|S000005787|Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
YJL218W	0.0687314	SRD1	YJL218W||S000003754|Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YOR049C	0.0685043	SRD1	YOR049C|RSB1|S000005575|Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YPL274W	0.068394	SRD1	YPL274W|SAM3|S000006195|High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YDR174W	0.0679754	SRD1	YDR174W|HMO1|S000002581|Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YBR162C	0.0677761	SRD1	YBR162C|TOS1|S000000366|Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YOR284W	0.0676272	SRD1	YOR284W|HUA2|S000005810|Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YHR125W	0.0675584	SRD1	YHR125W||S000001167|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR032C	0.0675518	SRD1	YIR032C|DAL3|S000001471|Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YOR114W	0.0666335	SRD1	YOR114W||S000005640|Putative protein of unknown function; null mutant is viable
YDR241W	0.0664927	SRD1	YDR241W|BUD26|S000002649|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YHR145C	0.0663561	SRD1	YHR145C||S000001188|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL138C	0.0660104	SRD1	YJL138C|TIF2|S000003674|Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YCR018C-A	0.0658658	SRD1	YCR018C-A||S000007230|Putative protein of unknown function; encoded opposite a Ty1 LTR
YOR098C	0.0652098	SRD1	YOR098C|NUP1|S000005624|Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
YPL039W	0.0651669	SRD1	YPL039W||S000005960|Putative protein of unknown function; YPL039W is not an essential gene
YBR021W	0.0650748	SRD1	YBR021W|FUR4|S000000225|Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YKL112W	0.0644445	SRD1	YKL112W|ABF1|S000001595|DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YJR020W	0.0638893	SRD1	YJR020W||S000003781|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL102W	0.0636217	SRD1	YBL102W|SFT2|S000000198|Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YDR135C	0.0636051	SRD1	YDR135C|YCF1|S000002542|Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR
YLR315W	0.0634912	SRD1	YLR315W|NKP2|S000004307|Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
YOR321W	0.0634588	SRD1	YOR321W|PMT3|S000005848|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals
YGR101W	0.063356	SRD1	YGR101W|PCP1|S000003333|Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
YNL211C	0.0633116	SRD1	YNL211C||S000005155|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
YDR092W	0.0630906	SRD1	YDR092W|UBC13|S000002499|Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YFL014W	0.0629252	SRD1	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YKL109W	0.0627504	SRD1	YKL109W|HAP4|S000001592|Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YAR068W	0.0627127	SRD1	YAR068W||S000000091|Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YFL025C	0.0626954	SRD1	YFL025C|BST1|S000001869|GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
YER182W	0.0624885	SRD1	YER182W|FMP10|S000000984|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR428C	0.0620962	SRD1	YDR428C|BNA7|S000002836|Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
YER014C-A	0.0620219	SRD1	YER014C-A|BUD25|S000007590|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLR247C	0.0619315	SRD1	YLR247C|IRC20|S000004237|Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YHR083W	0.0613798	SRD1	YHR083W|SAM35|S000001125|Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YOL151W	0.0612276	SRD1	YOL151W|GRE2|S000005511|3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YMR306C-A	0.0611724	SRD1	YMR306C-A||S000004922|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR052C-A	0.0611516	SRD1	YMR052C-A||S000004655|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL126C	0.0611416	SRD1	YDL126C|CDC48|S000002284|ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
YMR103C	0.0606471	SRD1	YMR103C||S000004709|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR411C	0.0604027	SRD1	YDR411C|DFM1|S000002819|ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes
YGL040C	0.0601845	SRD1	YGL040C|HEM2|S000003008|Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YBR193C	0.0600475	SRD1	YBR193C|MED8|S000000397|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YMR071C	0.0599688	SRD1	YMR071C|TVP18|S000004675|Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
YJR046W	0.0591196	SRD1	YJR046W|TAH11|S000003807|DNA replication licensing factor, required for pre-replication complex assembly
YCR011C	0.0584161	SRD1	YCR011C|ADP1|S000000604|Putative ATP-dependent permease of the ABC transporter family of proteins
YDR136C	0.0582793	SRD1	YDR136C|VPS61|S000002543|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
YJL206C	0.0582161	SRD1	YJL206C||S000003741|Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment
YNL062C	0.0578418	SRD1	YNL062C|GCD10|S000005006|Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YLR393W	0.0578122	SRD1	YLR393W|ATP10|S000004385|Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YDL147W	0.0577385	SRD1	YDL147W|RPN5|S000002306|Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
YKR051W	0.0576804	SRD1	YKR051W||S000001759|Putative protein of unknown function
YKL127W	0.0576289	SRD1	YKL127W|PGM1|S000001610|Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YBR280C	0.057426	SRD1	YBR280C|SAF1|S000000484|F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YBR219C	0.0574063	SRD1	YBR219C||S000000423|Putative protein of unknown function; YBR219C is not an essential gene
YML081C-A	0.0569888	SRD1	YML081C-A|ATP18|S000007247|Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YGL012W	0.0567096	SRD1	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YNL104C	0.0564328	SRD1	YNL104C|LEU4|S000005048|Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YPL272C	0.0563566	SRD1	YPL272C||S000006193|Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YBL081W	0.0560838	SRD1	YBL081W||S000000177|Non-essential protein of unknown function
YER112W	0.0560325	SRD1	YER112W|LSM4|S000000914|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR209C	0.0555646	SRD1	YLR209C|PNP1|S000004199|Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
YKR018C	0.0555109	SRD1	YKR018C||S000001726|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YMR312W	0.0550323	SRD1	YMR312W|ELP6|S000004929|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
YPL059W	0.0548408	SRD1	YPL059W|GRX5|S000005980|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
YKL091C	0.0544998	SRD1	YKL091C||S000001574|Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YPL094C	0.05418	SRD1	YPL094C|SEC62|S000006015|Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YLR027C	0.0535291	SRD1	YLR027C|AAT2|S000004017|Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YBR133C	0.0534957	SRD1	YBR133C|HSL7|S000000337|Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YBR144C	0.0533916	SRD1	YBR144C||S000000348|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YOR072W-B	0.0531803	SRD1	YOR072W-B||S000028516|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YIL029C	0.053137	SRD1	YIL029C||S000001291|Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDL174C	0.053135	SRD1	YDL174C|DLD1|S000002333|D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YML052W	0.0528815	SRD1	YML052W|SUR7|S000004516|Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YDR014W-A	0.0527611	SRD1	YDR014W-A|HED1|S000113613|Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YOR103C	0.0526594	SRD1	YOR103C|OST2|S000005629|Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YMR018W	0.0522454	SRD1	YMR018W||S000004620|Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YML070W	0.0521719	SRD1	YML070W|DAK1|S000004535|Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YHR075C	0.0521547	SRD1	YHR075C|PPE1|S000001117|Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YLR294C	0.0519601	SRD1	YLR294C||S000004285|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YPR015C	0.0518868	SRD1	YPR015C||S000006219|Putative protein of unknown function
YGR254W	0.0516279	SRD1	YGR254W|ENO1|S000003486|Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YMR274C	0.0516022	SRD1	YMR274C|RCE1|S000004887|Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
YDR126W	0.0514821	SRD1	YDR126W|SWF1|S000002533|Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
YFR026C	0.0514533	SRD1	YFR026C||S000001922|Putative protein of unknown function
YOL047C	0.0509898	SRD1	YOL047C||S000005407|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YIL014C-A	0.0509619	SRD1	YIL014C-A||S000003536|Putative protein of unknown function
YCR007C	0.0506874	SRD1	YCR007C||S000000600|Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YHL025W	0.0504848	SRD1	YHL025W|SNF6|S000001017|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
YPR159W	0.0503579	SRD1	YPR159W|KRE6|S000006363|Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p
YNL005C	0.0503573	SRD1	YNL005C|MRP7|S000004950|Mitochondrial ribosomal protein of the large subunit
YOR255W	0.050264	SRD1	YOR255W|OSW1|S000005781|Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
YBR056W	0.0501947	SRD1	YBR056W||S000000260|Putative cytoplasmic protein of unknown function
YML083C	0.0501808	SRD1	YML083C||S000004548|Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YNL177C	0.0500023	SRD1	YNL177C|MRPL22|S000005121|Mitochondrial ribosomal protein of the large subunit
YKL142W	0.0497468	SRD1	YKL142W|MRP8|S000001625|Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2
YPR094W	0.0497264	SRD1	YPR094W|RDS3|S000006298|Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
YPR002C-A	0.0496538	SRD1	YPR002C-A||S000007254|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12
YOR215C	0.0496158	SRD1	YOR215C|AIM41|S000005741|Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays altered rate of mitochondrial loss and reduced growth rate in minimal glycerol media
YJL178C	0.0492629	SRD1	YJL178C|ATG27|S000003714|Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the pre-autophagosomal structure; binds phosphatidylinositol 3-phosphate
YDR296W	0.0491491	SRD1	YDR296W|MHR1|S000002704|Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning
YDR090C	0.049122	SRD1	YDR090C||S000002497|Putative protein of unknown function
YFR044C	0.0490312	SRD1	YFR044C|DUG1|S000001940|Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YPR012W	0.0489954	SRD1	YPR012W||S000006216|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
YJR019C	0.0487922	SRD1	YJR019C|TES1|S000003780|Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YJR045C	0.0487293	SRD1	YJR045C|SSC1|S000003806|Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YPR127W	0.0487016	SRD1	YPR127W||S000006331|Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR353C	0.0483943	SRD1	YOR353C|SOG2|S000005880|Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
YHR048W	0.0482883	SRD1	YHR048W|YHK8|S000001090|Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YMR311C	0.0480846	SRD1	YMR311C|GLC8|S000004928|Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YAL042W	0.0479275	SRD1	YAL042W|ERV46|S000000040|Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
YOL058W	0.0476587	SRD1	YOL058W|ARG1|S000005419|Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YIL129C	0.0476012	SRD1	YIL129C|TAO3|S000001391|Protein involved in cell morphogenesis and proliferation, associated with protein kinase Cbk1p; mutants activate OCH1 transcription
YDR340W	0.0474386	SRD1	YDR340W||S000002748|Putative protein of unknown function
YBR082C	0.0466194	SRD1	YBR082C|UBC4|S000000286|Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YBR037C	0.0465325	SRD1	YBR037C|SCO1|S000000241|Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YCR022C	0.0458955	SRD1	YCR022C||S000000616|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YEL031W	0.0458788	SRD1	YEL031W|SPF1|S000000757|P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YDR281C	0.0456052	SRD1	YDR281C|PHM6|S000002689|Protein of unknown function, expression is regulated by phosphate levels
YGL014W	0.0455937	SRD1	YGL014W|PUF4|S000002982|Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
YPL282C	0.0455255	SRD1	YPL282C|PAU22|S000006203|Hypothetical protein
YNL133C	0.04543	SRD1	YNL133C|FYV6|S000005077|Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YGL003C	0.0454061	SRD1	YGL003C|CDH1|S000002971|Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
YOR213C	0.0450612	SRD1	YOR213C|SAS5|S000005739|Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
YER081W	0.0449939	SRD1	YER081W|SER3|S000000883|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p
YIL045W	0.0448632	SRD1	YIL045W|PIG2|S000001307|Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YBL093C	0.0446018	SRD1	YBL093C|ROX3|S000000189|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
YNL274C	0.0444823	SRD1	YNL274C|GOR1|S000005218|Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR184W	0.0442569	SRD1	YHR184W|SSP1|S000001227|Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
YJL055W	0.0441473	SRD1	YJL055W||S000003591|Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
YGR192C	0.044049	SRD1	YGR192C|TDH3|S000003424|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YLR307W	0.0437437	SRD1	YLR307W|CDA1|S000004298|Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YGR070W	0.0436994	SRD1	YGR070W|ROM1|S000003302|GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YPL240C	0.0434503	SRD1	YPL240C|HSP82|S000006161|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YCL021W-A	0.0431423	SRD1	YCL021W-A||S000007549|Putative protein of unknown function
YOR257W	0.0427509	SRD1	YOR257W|CDC31|S000005783|Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
YGR207C	0.0425005	SRD1	YGR207C||S000003439|Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR022W	0.0422889	SRD1	YBR022W|POA1|S000000226|Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
YNL220W	0.0420554	SRD1	YNL220W|ADE12|S000005164|Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
YBR194W	0.0418722	SRD1	YBR194W|AIM4|S000000398|Protein proposed to be associated with the nuclear pore complex; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and a severe growth defect in minimal glycerol media
YDR434W	0.0417544	SRD1	YDR434W|GPI17|S000002842|Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YNL124W	0.0416541	SRD1	YNL124W|NAF1|S000005068|Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
YFL046W	0.041286	SRD1	YFL046W|FMP32|S000001848|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL042C-A	0.0408111	SRD1	YAL042C-A||S000002138|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene
YHR082C	0.0407956	SRD1	YHR082C|KSP1|S000001124|Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YGL004C	0.0404586	SRD1	YGL004C|RPN14|S000002972|Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm
YBL039W-B	0.0401431	SRD1	YBL039W-B||S000028517|Putative protein of unknown function
YNL284C	0.040046	SRD1	YNL284C|MRPL10|S000005228|Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
YER093C-A	0.0400337	SRD1	YER093C-A|AIM11|S000002960|Putative protein of unknown function; YER093C-A contains an intron; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YER051W	0.0397876	SRD1	YER051W|JHD1|S000000853|JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
YJL120W	0.0397417	SRD1	YJL120W||S000003656|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
YAL016W	0.0396296	SRD1	YAL016W|TPD3|S000000014|Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III
YLR121C	0.0395446	SRD1	YLR121C|YPS3|S000004111|Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YDL196W	0.0395396	SRD1	YDL196W||S000002355|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YDR504C	0.0392909	SRD1	YDR504C|SPG3|S000002912|Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YIL073C	0.0392189	SRD1	YIL073C|SPO22|S000001335|Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis
YHL026C	0.0390323	SRD1	YHL026C||S000001018|Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YPR192W	0.0389939	SRD1	YPR192W|AQY1|S000006396|Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YBL025W	0.0386676	SRD1	YBL025W|RRN10|S000000121|Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YPL184C	0.0386172	SRD1	YPL184C|MRN1|S000006105|Putative RNA binding protein
YGR133W	0.0385545	SRD1	YGR133W|PEX4|S000003365|Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
YDL012C	0.0385504	SRD1	YDL012C||S000002170|Plasma membrane protein of unknown function; YDL012C is not an essential gene
YPR170W-B	0.0385006	SRD1	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YGR132C	0.0383878	SRD1	YGR132C|PHB1|S000003364|Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YBR134W	0.0383739	SRD1	YBR134W||S000000338|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR074W	0.037603	SRD1	YHR074W|QNS1|S000001116|Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YOR008C	0.0375434	SRD1	YOR008C|SLG1|S000005534|Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
YNR004W	0.0370618	SRD1	YNR004W||S000005287|Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C
YLR403W	0.036889	SRD1	YLR403W|SFP1|S000004395|Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YER056C	0.0368556	SRD1	YER056C|FCY2|S000000858|Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
YDR171W	0.0368284	SRD1	YDR171W|HSP42|S000002578|Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YLR402W	0.0365992	SRD1	YLR402W||S000004394|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL050C	0.0361612	SRD1	YFL050C|ALR2|S000001844|Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
YJR127C	0.0361034	SRD1	YJR127C|RSF2|S000003888|Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions
YGR088W	0.0360018	SRD1	YGR088W|CTT1|S000003320|Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YGR120C	0.0359847	SRD1	YGR120C|COG2|S000003352|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL285W	0.035415	SRD1	YNL285W||S000005229|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL242W	0.0352409	SRD1	YDL242W||S000002401|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL010C	0.0352044	SRD1	YKL010C|UFD4|S000001493|Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
YNL179C	0.0351663	SRD1	YNL179C||S000005123|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YDR008C	0.0350668	SRD1	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR422W	0.0349818	SRD1	YLR422W||S000004414|Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
YBR149W	0.0347436	SRD1	YBR149W|ARA1|S000000353|NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YJR051W	0.0345459	SRD1	YJR051W|OSM1|S000003812|Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity
YDR103W	0.0344446	SRD1	YDR103W|STE5|S000002510|Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YGR146C	0.0343847	SRD1	YGR146C||S000003378|Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR223W	0.0342828	SRD1	YDR223W|CRF1|S000002631|Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YHR204W	0.0340455	SRD1	YHR204W|MNL1|S000001247|Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
YMR040W	0.0339688	SRD1	YMR040W|YET2|S000004643|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YLR089C	0.0338652	SRD1	YLR089C|ALT1|S000004079|Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR043C	0.0336656	SRD1	YHR043C|DOG2|S000001085|2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
YIL029W-A	0.0335191	SRD1	YIL029W-A||S000028788|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL024C	0.033187	SRD1	YNL024C||S000004969|Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YKL186C	0.0326791	SRD1	YKL186C|MTR2|S000001669|mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
YGL107C	0.0326699	SRD1	YGL107C|RMD9|S000003075|Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
YPR064W	0.0322262	SRD1	YPR064W||S000006268|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YMR237W	0.0320358	SRD1	YMR237W|BCH1|S000004850|Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes
YCR028C	0.0319671	SRD1	YCR028C|FEN2|S000000623|Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph
YER067W	0.0318649	SRD1	YER067W||S000000869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YDL097C	0.0318229	SRD1	YDL097C|RPN6|S000002255|Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
YPR035W	0.0317876	SRD1	YPR035W|GLN1|S000006239|Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YGL167C	0.0317671	SRD1	YGL167C|PMR1|S000003135|High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
YLR256W	0.0316016	SRD1	YLR256W|HAP1|S000004246|Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YML025C	0.0314237	SRD1	YML025C|YML6|S000004487|Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
YNR071C	0.031249	SRD1	YNR071C||S000005354|Putative protein of unknown function
YNL300W	0.031238	SRD1	YNL300W||S000005244|Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YGR010W	0.0312108	SRD1	YGR010W|NMA2|S000003242|Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+)
YJL144W	0.0312067	SRD1	YJL144W||S000003680|Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YML012C-A	0.0311505	SRD1	YML012C-A||S000004474|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1
YBR052C	0.0310141	SRD1	YBR052C|RFS1|S000000256|Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YHR210C	0.0307503	SRD1	YHR210C||S000001253|Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YBR107C	0.0303491	SRD1	YBR107C|IML3|S000000311|Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
YER048W-A	0.0303068	SRD1	YER048W-A|ISD11|S000007237|Protein required for mitochondrial iron-sulfur cluster biosynthesis
YMR253C	0.0299564	SRD1	YMR253C||S000004866|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YPR067W	0.0298187	SRD1	YPR067W|ISA2|S000006271|Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
YLR112W	0.0297735	SRD1	YLR112W||S000004102|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL109C	0.0297275	SRD1	YDL109C||S000002267|Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene
YIL084C	0.0294472	SRD1	YIL084C|SDS3|S000001346|Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
YHR011W	0.0293585	SRD1	YHR011W|DIA4|S000001053|Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
YDR137W	0.0292468	SRD1	YDR137W|RGP1|S000002544|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
YPR166C	0.0289821	SRD1	YPR166C|MRP2|S000006370|Mitochondrial ribosomal protein of the small subunit
YMR279C	0.0289208	SRD1	YMR279C||S000004892|Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YIL050W	0.0288542	SRD1	YIL050W|PCL7|S000001312|Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YCL041C	0.0287335	SRD1	YCL041C||S000000546|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
YDL195W	0.0285578	SRD1	YDL195W|SEC31|S000002354|Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation
YKR098C	0.0285265	SRD1	YKR098C|UBP11|S000001806|Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
YCL026C-A	0.0282482	SRD1	YCL026C-A|FRM2|S000000589|Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases
YAL016C-A	0.0281801	SRD1	YAL016C-A||S000028728|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL080W	0.0281133	SRD1	YKL080W|VMA5|S000001563|Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YMR098C	0.0278595	SRD1	YMR098C|ATP25|S000004704|Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YGR121C	0.0277823	SRD1	YGR121C|MEP1|S000003353|Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YGL199C	0.0277294	SRD1	YGL199C||S000003167|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
YIL007C	0.0276526	SRD1	YIL007C|NAS2|S000001269|Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p
YGR036C	0.0274685	SRD1	YGR036C|CAX4|S000003268|Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YLR365W	0.0274363	SRD1	YLR365W||S000004357|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YPL025C	0.0272098	SRD1	YPL025C||S000005946|Hypothetical protein
YGR239C	0.0271523	SRD1	YGR239C|PEX21|S000003471|Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YDL057W	0.026677	SRD1	YDL057W||S000002215|Putative protein of unknown function; YDL057W is not an essential gene
YDL188C	0.0262901	SRD1	YDL188C|PPH22|S000002347|Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YNL025C	0.0261065	SRD1	YNL025C|SSN8|S000004970|Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
YDL243C	0.0259618	SRD1	YDL243C|AAD4|S000002402|Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YPR070W	0.0259392	SRD1	YPR070W|MED1|S000006274|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YBR085W	0.0257231	SRD1	YBR085W|AAC3|S000000289|Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YKL032C	0.0256857	SRD1	YKL032C|IXR1|S000001515|Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YNR061C	0.0254415	SRD1	YNR061C||S000005344|Putative protein of unknown function
YDR047W	0.0252528	SRD1	YDR047W|HEM12|S000002454|Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YIL006W	0.0250829	SRD1	YIL006W|YIA6|S000001268|Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
YFL061W	0.0247068	SRD1	YFL061W|DDI2|S000001833|Protein whose expression is induced by DNA damage
YJR034W	0.0246983	SRD1	YJR034W|PET191|S000003795|Protein required for assembly of cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL004W	0.0246475	SRD1	YHL004W|MRP4|S000000996|Mitochondrial ribosomal protein of the small subunit
YFR030W	0.0243214	SRD1	YFR030W|MET10|S000001926|Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YPL047W	0.024321	SRD1	YPL047W|SGF11|S000005968|Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
YMR150C	0.0243157	SRD1	YMR150C|IMP1|S000004758|Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YLR299W	0.0242173	SRD1	YLR299W|ECM38|S000004290|Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YOR124C	0.0241738	SRD1	YOR124C|UBP2|S000005650|Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity
YML058W-A	0.0235794	SRD1	YML058W-A|HUG1|S000007472|Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage
YPR009W	0.0234955	SRD1	YPR009W|SUT2|S000006213|Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YBR078W	0.0232071	SRD1	YBR078W|ECM33|S000000282|GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YKL071W	0.0231659	SRD1	YKL071W||S000001554|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJL171C	0.0226511	SRD1	YJL171C||S000003707|GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
YER189W	0.0224805	SRD1	YER189W||S000000991|Putative protein of unknown function
YDR221W	0.0223709	SRD1	YDR221W|GTB1|S000002629|Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER
YER050C	0.0222658	SRD1	YER050C|RSM18|S000000852|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
YOL042W	0.02221	SRD1	YOL042W|NGL1|S000005402|Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL078W	0.0222022	SRD1	YNL078W|NIS1|S000005022|Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YDL127W	0.0221731	SRD1	YDL127W|PCL2|S000002285|G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth
YGL160W	0.0220497	SRD1	YGL160W|AIM14|S000003128|Putative protein of unknown function; similar to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes, null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDR258C	0.0219923	SRD1	YDR258C|HSP78|S000002666|Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YJL174W	0.0219865	SRD1	YJL174W|KRE9|S000003710|Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
YOL117W	0.0219687	SRD1	YOL117W|RRI2|S000005477|Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
YOR016C	0.0218246	SRD1	YOR016C|ERP4|S000005542|Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YBR076C-A	0.0217827	SRD1	YBR076C-A||S000028533|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YHL046C	0.0214993	SRD1	YHL046C|PAU13|S000001038|Putative protein of unknown function; not an essential gene
YNL328C	0.0213906	SRD1	YNL328C|MDJ2|S000005272|Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
YMR151W	0.02095	SRD1	YMR151W|YIM2|S000004759|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
YNL327W	0.0207679	SRD1	YNL327W|EGT2|S000005271|Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YDR532C	0.0207549	SRD1	YDR532C||S000002940|Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p
YBR109W-A	0.0207252	SRD1	YBR109W-A||S000028737|Putative protein of unknown function; questionable ORF from MIPS
YHL006C	0.0206743	SRD1	YHL006C|SHU1|S000000998|Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
YNL335W	0.0206648	SRD1	YNL335W|DDI3|S000005279|Hypothetical protein
YHR076W	0.0206432	SRD1	YHR076W|PTC7|S000001118|Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YOR177C	0.0206306	SRD1	YOR177C|MPC54|S000005703|Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
YOR097C	0.0206066	SRD1	YOR097C||S000005623|Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene
YML056C	0.020525	SRD1	YML056C|IMD4|S000004520|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YOL077W-A	0.0201933	SRD1	YOL077W-A|ATP19|S000007339|Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
YDR222W	0.0201801	SRD1	YDR222W||S000002630|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YAL067C	0.0200514	SRD1	YAL067C|SEO1|S000000062|Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YFR045W	0.0200003	SRD1	YFR045W||S000001941|Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YLR148W	0.0199255	SRD1	YLR148W|PEP3|S000004138|Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
YHL045W	0.019878	SRD1	YHL045W||S000001037|Putative protein of unknown function; not an essential gene
YNL121C	0.0198248	SRD1	YNL121C|TOM70|S000005065|Component (70 kDa) of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
YOR179C	0.0186289	SRD1	YOR179C|SYC1|S000005705|Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
YOR057W	0.0184349	SRD1	YOR057W|SGT1|S000005583|Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex
YDR276C	0.0182076	SRD1	YDR276C|PMP3|S000002684|Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YOR197W	0.0181474	SRD1	YOR197W|MCA1|S000005723|Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment
YKL215C	0.0180163	SRD1	YKL215C||S000001698|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPL260W	0.0178306	SRD1	YPL260W||S000006181|Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene
YIL120W	0.0173984	SRD1	YIL120W|QDR1|S000001382|Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
YDR007W	0.0172989	SRD1	YDR007W|TRP1|S000002414|Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YER188C-A	0.01728	SRD1	YER188C-A||S000028764|Putative protein of unknown function
YBR250W	0.0171822	SRD1	YBR250W|SPO23|S000000454|Protein of unknown function; associates with meiosis-specific protein Spo1p
YPR156C	0.0165799	SRD1	YPR156C|TPO3|S000006360|Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YHR072W	0.0164331	SRD1	YHR072W|ERG7|S000001114|Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YMR089C	0.016379	SRD1	YMR089C|YTA12|S000004695|Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YGR033C	0.0163339	SRD1	YGR033C|TIM21|S000003265|Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes
YML055W	0.0163252	SRD1	YML055W|SPC2|S000004519|Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25
YIL116W	0.0162665	SRD1	YIL116W|HIS5|S000001378|Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YMR114C	0.0161333	SRD1	YMR114C||S000004720|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
YGL117W	0.0161326	SRD1	YGL117W||S000003085|Putative protein of unknown function
YLL015W	0.0161079	SRD1	YLL015W|BPT1|S000003938|ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
YGR286C	0.0157699	SRD1	YGR286C|BIO2|S000003518|Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YDL006W	0.0155572	SRD1	YDL006W|PTC1|S000002164|Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
YHR041C	0.015431	SRD1	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YCL043C	0.0153134	SRD1	YCL043C|PDI1|S000000548|Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds
YAL028W	0.0150851	SRD1	YAL028W|FRT2|S000000026|Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YNL128W	0.0150628	SRD1	YNL128W|TEP1|S000005072|Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation
YGR230W	0.0149423	SRD1	YGR230W|BNS1|S000003462|Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
YML098W	0.0149391	SRD1	YML098W|TAF13|S000004564|TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
YEL050C	0.0149135	SRD1	YEL050C|RML2|S000000776|Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YGL139W	0.014677	SRD1	YGL139W|FLC3|S000003107|Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YIL048W	0.0145257	SRD1	YIL048W|NEO1|S000001310|Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YOR262W	0.0144929	SRD1	YOR262W||S000005788|Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B
YFR023W	0.0144646	SRD1	YFR023W|PES4|S000001919|Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YJL119C	0.0144354	SRD1	YJL119C||S000003655|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR006C	0.0142586	SRD1	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR231W	0.0142471	SRD1	YOR231W|MKK1|S000005757|Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p
YPL230W	0.0141224	SRD1	YPL230W|USV1|S000006151|Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YBR110W	0.01394	SRD1	YBR110W|ALG1|S000000314|Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
YER147C-A	0.0138535	SRD1	YER147C-A||S000028759|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL164W	0.0137493	SRD1	YOL164W|BDS1|S000005524|Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources
YGR178C	0.0137011	SRD1	YGR178C|PBP1|S000003410|Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YML076C	0.0136417	SRD1	YML076C|WAR1|S000004541|Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
YAR069C	0.0136379	SRD1	YAR069C||S000000092|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR108W	0.0136378	SRD1	YBR108W|AIM3|S000000312|Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YHR073W	0.0136229	SRD1	YHR073W|OSH3|S000001115|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YGR161W-C	0.0136094	SRD1	YGR161W-C||S000029726|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YKL210W	0.0135711	SRD1	YKL210W|UBA1|S000001693|Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability
YFL055W	0.013149	SRD1	YFL055W|AGP3|S000001839|Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YMR068W	0.01286	SRD1	YMR068W|AVO2|S000004672|Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YCR003W	0.012715	SRD1	YCR003W|MRPL32|S000000596|Mitochondrial ribosomal protein of the large subunit
YLR278C	0.0126246	SRD1	YLR278C||S000004268|Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YER148W	0.0124818	SRD1	YER148W|SPT15|S000000950|TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YPL261C	0.0124751	SRD1	YPL261C||S000006182|Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
YDR294C	0.0124709	SRD1	YDR294C|DPL1|S000002702|Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
YML099C	0.0122501	SRD1	YML099C|ARG81|S000004565|Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
YPL028W	0.0119257	SRD1	YPL028W|ERG10|S000005949|Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YEL049W	0.0118377	SRD1	YEL049W|PAU2|S000000775|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YIL034C	0.0117415	SRD1	YIL034C|CAP2|S000001296|Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YKR062W	0.0115476	SRD1	YKR062W|TFA2|S000001770|TFIIE small subunit, involved in RNA polymerase II transcription initiation
YHR071C-A	0.0115237	SRD1	YHR071C-A||S000028781|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W
YBR044C	0.0113213	SRD1	YBR044C|TCM62|S000000248|Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YHR001W	0.0111574	SRD1	YHR001W|OSH7|S000001043|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YAL067W-A	0.0111329	SRD1	YAL067W-A||S000028593|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL190C	0.0111003	SRD1	YPL190C|NAB3|S000006111|Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p
YDR091C	0.011047	SRD1	YDR091C|RLI1|S000002498|Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YBL001C	0.0108597	SRD1	YBL001C|ECM15|S000000097|Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
YOL033W	0.0108317	SRD1	YOL033W|MSE1|S000005393|Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene
YNL232W	0.0107875	SRD1	YNL232W|CSL4|S000005176|Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation
YOR007C	0.0107153	SRD1	YOR007C|SGT2|S000005533|Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70
YMR059W	0.0104979	SRD1	YMR059W|SEN15|S000004663|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YHR005C-A	0.0100831	SRD1	YHR005C-A|MRS11|S000003530|Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YJL005W	0.0100591	SRD1	YJL005W|CYR1|S000003542|Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YBR243C	0.0100578	SRD1	YBR243C|ALG7|S000000447|UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YDR158W	0.00993633	SRD1	YDR158W|HOM2|S000002565|Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YGR215W	0.00964338	SRD1	YGR215W|RSM27|S000003447|Mitochondrial ribosomal protein of the small subunit
YNL079C	0.0096232	SRD1	YNL079C|TPM1|S000005023|Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YDL119C	0.00951936	SRD1	YDL119C||S000002277|Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
YLR421C	0.00949988	SRD1	YLR421C|RPN13|S000004413|Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome
YLR390W-A	0.00944333	SRD1	YLR390W-A|CCW14|S000006429|Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
YMR266W	0.00938132	SRD1	YMR266W|RSN1|S000004879|Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YDR121W	0.00937594	SRD1	YDR121W|DPB4|S000002528|Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
YOR053W	0.00923762	SRD1	YOR053W||S000005579|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
YKL090W	0.00923346	SRD1	YKL090W|CUE2|S000001573|Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YGL096W	0.0091987	SRD1	YGL096W|TOS8|S000003064|Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YDR463W	0.00902023	SRD1	YDR463W|STP1|S000002871|Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing
YBR295W	0.00889161	SRD1	YBR295W|PCA1|S000000499|Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YFL004W	0.0087835	SRD1	YFL004W|VTC2|S000001890|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion
YML081W	0.00842169	SRD1	YML081W||S000004546|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YPL259C	0.00833508	SRD1	YPL259C|APM1|S000006180|Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YDR353W	0.00810665	SRD1	YDR353W|TRR1|S000002761|Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YLR268W	0.00803554	SRD1	YLR268W|SEC22|S000004258|R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YMR307W	0.00797	SRD1	YMR307W|GAS1|S000004924|Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YKL162C	0.00757903	SRD1	YKL162C||S000001645|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YER066C-A	0.00755664	SRD1	YER066C-A||S000002959|Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
YDL118W	0.00750975	SRD1	YDL118W||S000002276|Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein
YLR324W	0.00730835	SRD1	YLR324W|PEX30|S000004316|Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YKR059W	0.00730303	SRD1	YKR059W|TIF1|S000001767|Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YIL101C	0.00714029	SRD1	YIL101C|XBP1|S000001363|Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YNL185C	0.00712912	SRD1	YNL185C|MRPL19|S000005129|Mitochondrial ribosomal protein of the large subunit
YNL320W	0.00710081	SRD1	YNL320W||S000005264|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL187W	0.00704735	SRD1	YPL187W|MF(ALPHA)1|S000006108|Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YOR232W	0.00699554	SRD1	YOR232W|MGE1|S000005758|Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE
YAL058W	0.00699262	SRD1	YAL058W|CNE1|S000000054|Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
YHR042W	0.00672726	SRD1	YHR042W|NCP1|S000001084|NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
YKL138C-A	0.00649526	SRD1	YKL138C-A|HSK3|S000028421|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YDR176W	0.00620583	SRD1	YDR176W|NGG1|S000002583|Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
YGL001C	0.00611705	SRD1	YGL001C|ERG26|S000002969|C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YPL172C	0.00592137	SRD1	YPL172C|COX10|S000006093|Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
YOL152W	0.00563621	SRD1	YOL152W|FRE7|S000005512|Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YIL039W	0.00552192	SRD1	YIL039W|TED1|S000001301|Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YML035C	0.00547729	SRD1	YML035C|AMD1|S000004498|AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
YDR057W	0.00546172	SRD1	YDR057W|YOS9|S000002464|ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family
YMR137C	0.00543249	SRD1	YMR137C|PSO2|S000004745|Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation
YDR503C	0.00542216	SRD1	YDR503C|LPP1|S000002911|Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
YNL184C	0.00504008	SRD1	YNL184C||S000005128|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML023C	0.00473059	SRD1	YML023C|NSE5|S000004485|Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair
YHR159W	0.00464989	SRD1	YHR159W||S000001202|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YLR345W	0.00456064	SRD1	YLR345W||S000004337|Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
YGL254W	0.00447592	SRD1	YGL254W|FZF1|S000003223|Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers
YNR049C	0.00425503	SRD1	YNR049C|MSO1|S000005332|Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions; required for sporulation
YCR012W	0.00415658	SRD1	YCR012W|PGK1|S000000605|3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YIL036W	0.00414831	SRD1	YIL036W|CST6|S000001298|Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance
YLR166C	0.00399306	SRD1	YLR166C|SEC10|S000004156|Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
YOR017W	0.00385717	SRD1	YOR017W|PET127|S000005543|Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane
YFL056C	0.00380514	SRD1	YFL056C|AAD6|S000001838|Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YER133W	0.00348084	SRD1	YER133W|GLC7|S000000935|Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YDL227C	0.0034467	SRD1	YDL227C|HO|S000002386|Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
YLL060C	0.00335601	SRD1	YLL060C|GTT2|S000003983|Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YBR068C	0.00323628	SRD1	YBR068C|BAP2|S000000272|High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains
YJL159W	0.00248639	SRD1	YJL159W|HSP150|S000003695|O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation
YDL207W	0.00236571	SRD1	YDL207W|GLE1|S000002366|Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal
YKR096W	0.00215753	SRD1	YKR096W||S000001804|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain
YDL011C	0.00214621	SRD1	YDL011C||S000002169|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YGR198W	0.00213719	SRD1	YGR198W|YPP1|S000003430|Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
YBR164C	0.00204189	SRD1	YBR164C|ARL1|S000000368|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YFL021W	0.0020356	SRD1	YFL021W|GAT1|S000001873|Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YOR033C	0.00203212	SRD1	YOR033C|EXO1|S000005559|5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
YKL075C	0.00196052	SRD1	YKL075C||S000001558|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
YBR186W	0.00194737	SRD1	YBR186W|PCH2|S000000390|Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA
YER119C-A	0.00192668	SRD1	YER119C-A||S000002961|Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
YDR408C	0.00183641	SRD1	YDR408C|ADE8|S000002816|Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YKR101W	0.00183518	SRD1	YKR101W|SIR1|S000001809|Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YML022W	0.0017629	SRD1	YML022W|APT1|S000004484|Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YER111C	0.00171875	SRD1	YER111C|SWI4|S000000913|DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YDR335W	0.00167995	SRD1	YDR335W|MSN5|S000002743|Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP
YGL077C	0.00155598	SRD1	YGL077C|HNM1|S000003045|Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YMR099C	0.00120356	SRD1	YMR099C||S000004705|Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YNL219C	0.0011536	SRD1	YNL219C|ALG9|S000005163|Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
YFR009W	0.00101747	SRD1	YFR009W|GCN20|S000001905|Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YJR033C	0.00100411	SRD1	YJR033C|RAV1|S000003794|Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
YGR125W	0.00080814	SRD1	YGR125W||S000003357|Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YMR138W	0.000764516	SRD1	YMR138W|CIN4|S000004746|GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
YGL032C	0.000661377	SRD1	YGL032C|AGA2|S000003000|Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YER190W	0.00063826	SRD1	YER190W|YRF1-2|S000000992|Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR115W	0.000444345	SRD1	YMR115W|FMP24|S000004721|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR145C	0.000276335	SRD1	YMR145C|NDE1|S000004753|Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YMR201C	0.000221795	SRD1	YMR201C|RAD14|S000004814|Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
YMR135W-A	0.000181932	SRD1	YMR135W-A||S000004743|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL140W	0.000142137	SRD1	YKL140W|TGL1|S000001623|Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
