YLR154C	29.7274	YDR026c	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-A	24.9315	YDR026c	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B	24.7436	YDR026c	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR242W	23.3902	YDR026c	YGR242W||S000003474|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YFR055W	22.6359	YDR026c	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YCR031C	22.0866	YDR026c	YCR031C|RPS14A|S000000627|Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YGR241C	20.3217	YDR026c	YGR241C|YAP1802|S000003473|Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YFR056C	19.8016	YDR026c	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YHR094C	17.9442	YDR026c	YHR094C|HXT1|S000001136|Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YIL118W	17.3418	YDR026c	YIL118W|RHO3|S000001380|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDR098C	17.035	YDR026c	YDR098C|GRX3|S000002505|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YML043C	17.0243	YDR026c	YML043C|RRN11|S000004507|Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YGR264C	16.9031	YDR026c	YGR264C|MES1|S000003496|Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR265W	16.4254	YDR026c	YGR265W||S000003497|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YLR154W-C	15.902	YDR026c	YLR154W-C|TAR1|S000028422|Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YER131W	15.8495	YDR026c	YER131W|RPS26B|S000000933|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YMR001C-A	14.6015	YDR026c	YMR001C-A||S000028691|Putative protein of unknown function
YOL124C	14.599	YDR026c	YOL124C|TRM11|S000005484|Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YMR183C	14.3374	YDR026c	YMR183C|SSO2|S000004795|Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YDR033W	12.6614	YDR026c	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YMR290W-A	12.5803	YDR026c	YMR290W-A||S000004904|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YMR290C	12.5283	YDR026c	YMR290C|HAS1|S000004903|ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YPR102C	12.4928	YDR026c	YPR102C|RPL11A|S000006306|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YOL005C	12.2526	YDR026c	YOL005C|RPB11|S000005365|RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YDL047W	12.2016	YDR026c	YDL047W|SIT4|S000002205|Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YJL107C	11.6098	YDR026c	YJL107C||S000003643|Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YDL085C-A	11.4929	YDR026c	YDL085C-A||S000007588|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YER146W	10.8814	YDR026c	YER146W|LSM5|S000000948|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR249W	10.6776	YDR026c	YLR249W|YEF3|S000004239|Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YJR094W-A	10.5993	YDR026c	YJR094W-A|RPL43B|S000003855|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YPR119W	10.505	YDR026c	YPR119W|CLB2|S000006323|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YPR074C	10.4759	YDR026c	YPR074C|TKL1|S000006278|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YLR212C	10.4693	YDR026c	YLR212C|TUB4|S000004202|Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YGL179C	10.3835	YDR026c	YGL179C|TOS3|S000003147|Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YMR123W	10.369	YDR026c	YMR123W|PKR1|S000004730|V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YOL086C	10.2	YDR026c	YOL086C|ADH1|S000005446|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YPR157W	10.1212	YDR026c	YPR157W||S000006361|Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR060W	10.0619	YDR026c	YGR060W|ERG25|S000003292|C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YOL123W	10.0134	YDR026c	YOL123W|HRP1|S000005483|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YKL218C	10.0028	YDR026c	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDR060W	9.86169	YDR026c	YDR060W|MAK21|S000002467|Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YOR063W	9.75431	YDR026c	YOR063W|RPL3|S000005589|Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YHR216W	9.54696	YDR026c	YHR216W|IMD2|S000001259|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YDR041W	9.52363	YDR026c	YDR041W|RSM10|S000002448|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YPR029C	9.49712	YDR026c	YPR029C|APL4|S000006233|Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YGL034C	9.33307	YDR026c	YGL034C||S000003002|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR369C	9.17987	YDR026c	YOR369C|RPS12|S000005896|Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YBL077W	9.0671	YDR026c	YBL077W||S000000173|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YFL022C	9.00008	YDR026c	YFL022C|FRS2|S000001872|Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YDR146C	8.97333	YDR026c	YDR146C|SWI5|S000002553|Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YFL015W-A	8.96619	YDR026c	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL079C	8.83458	YDR026c	YNL079C|TPM1|S000005023|Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YFL015C	8.66641	YDR026c	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGL035C	8.58532	YDR026c	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YPL075W	8.49204	YDR026c	YPL075W|GCR1|S000005996|Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YJL106W	8.49032	YDR026c	YJL106W|IME2|S000003642|Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YHR021C	8.48074	YDR026c	YHR021C|RPS27B|S000001063|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YDL007W	8.47049	YDR026c	YDL007W|RPT2|S000002165|One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YOR226C	8.33337	YDR026c	YOR226C|ISU2|S000005752|Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YDR040C	8.20087	YDR026c	YDR040C|ENA1|S000002447|P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YDR144C	8.13809	YDR026c	YDR144C|MKC7|S000002551|GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YKR038C	8.12968	YDR026c	YKR038C|KAE1|S000001746|Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YNL078W	8.11293	YDR026c	YNL078W|NIS1|S000005022|Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YGR266W	8.08661	YDR026c	YGR266W||S000003498|Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YDR279W	8.05622	YDR026c	YDR279W|RNH202|S000002687|Ribonuclease H2 subunit, required for RNase H2 activity
YKL182W	8.04963	YDR026c	YKL182W|FAS1|S000001665|Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YJR009C	8.04438	YDR026c	YJR009C|TDH2|S000003769|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YNL111C	7.95088	YDR026c	YNL111C|CYB5|S000005055|Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YML123C	7.94584	YDR026c	YML123C|PHO84|S000004592|High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YML121W	7.94404	YDR026c	YML121W|GTR1|S000004590|Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YER019C-A	7.91366	YDR026c	YER019C-A|SBH2|S000002127|Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YLL050C	7.87728	YDR026c	YLL050C|COF1|S000003973|Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YMR184W	7.86313	YDR026c	YMR184W|ADD37|S000004796|Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YCR004C	7.82081	YDR026c	YCR004C|YCP4|S000000597|Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL113W	7.80451	YDR026c	YNL113W|RPC19|S000005057|RNA polymerase subunit, common to RNA polymerases I and III
YPL037C	7.76657	YDR026c	YPL037C|EGD1|S000005958|Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YKL063C	7.76299	YDR026c	YKL063C||S000001546|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YNR016C	7.67157	YDR026c	YNR016C|ACC1|S000005299|Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YIL148W	7.64422	YDR026c	YIL148W|RPL40A|S000001410|Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YPR043W	7.639	YDR026c	YPR043W|RPL43A|S000006247|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YPL250W-A	7.63127	YDR026c	YPL250W-A||S000028589|Identified by fungal homology and RT-PCR
YGL148W	7.62597	YDR026c	YGL148W|ARO2|S000003116|Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YGL097W	7.61231	YDR026c	YGL097W|SRM1|S000003065|Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YEL053W-A	7.60853	YDR026c	YEL053W-A||S000028744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YML052W	7.39909	YDR026c	YML052W|SUR7|S000004516|Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YKL009W	7.21927	YDR026c	YKL009W|MRT4|S000001492|Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YNL090W	7.12256	YDR026c	YNL090W|RHO2|S000005034|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YML103C	7.07366	YDR026c	YML103C|NUP188|S000004571|Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YJL158C	7.06315	YDR026c	YJL158C|CIS3|S000003694|Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YDR023W	7.0331	YDR026c	YDR023W|SES1|S000002430|Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YHL015W	6.98794	YDR026c	YHL015W|RPS20|S000001007|Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YOR101W	6.93642	YDR026c	YOR101W|RAS1|S000005627|GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YML124C	6.78924	YDR026c	YML124C|TUB3|S000004593|Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YLR150W	6.75063	YDR026c	YLR150W|STM1|S000004140|Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YGR052W	6.67877	YDR026c	YGR052W|FMP48|S000003284|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR096W	6.57824	YDR026c	YBR096W||S000000300|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YKR013W	6.57532	YDR026c	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YER001W	6.55141	YDR026c	YER001W|MNN1|S000000803|Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YDL048C	6.44528	YDR026c	YDL048C|STP4|S000002206|Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YBL085W	6.40622	YDR026c	YBL085W|BOI1|S000000181|Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YOR153W	6.36434	YDR026c	YOR153W|PDR5|S000005679|Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YIL009W	6.23474	YDR026c	YIL009W|FAA3|S000001271|Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YNL066W	6.21107	YDR026c	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YKR092C	6.19937	YDR026c	YKR092C|SRP40|S000001800|Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YMR177W	6.13556	YDR026c	YMR177W|MMT1|S000004789|Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YHR144C	6.13492	YDR026c	YHR144C|DCD1|S000001187|Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YGL039W	5.92639	YDR026c	YGL039W||S000003007|Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YPL062W	5.90977	YDR026c	YPL062W||S000005983|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YHL028W	5.89998	YDR026c	YHL028W|WSC4|S000001020|ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YLR355C	5.85275	YDR026c	YLR355C|ILV5|S000004347|Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YER156C	5.84706	YDR026c	YER156C||S000000958|Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR272W	5.83536	YDR026c	YOR272W|YTM1|S000005798|Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YHR181W	5.81615	YDR026c	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YDL208W	5.81285	YDR026c	YDL208W|NHP2|S000002367|Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YPL256C	5.80785	YDR026c	YPL256C|CLN2|S000006177|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGL120C	5.80746	YDR026c	YGL120C|PRP43|S000003088|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YPL160W	5.80184	YDR026c	YPL160W|CDC60|S000006081|Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YOR276W	5.79306	YDR026c	YOR276W|CAF20|S000005802|Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YBR143C	5.76796	YDR026c	YBR143C|SUP45|S000000347|Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YDL191W	5.70221	YDR026c	YDL191W|RPL35A|S000002350|Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YGR050C	5.67034	YDR026c	YGR050C||S000003282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR015C	5.64299	YDR026c	YMR015C|ERG5|S000004617|C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YOL139C	5.61225	YDR026c	YOL139C|CDC33|S000005499|Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
YBL032W	5.6111	YDR026c	YBL032W|HEK2|S000000128|RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YEL001C	5.60836	YDR026c	YEL001C|IRC22|S000000727|Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YOR047C	5.60421	YDR026c	YOR047C|STD1|S000005573|Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YMR083W	5.5756	YDR026c	YMR083W|ADH3|S000004688|Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YPL231W	5.47414	YDR026c	YPL231W|FAS2|S000006152|Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated
YIL053W	5.40529	YDR026c	YIL053W|RHR2|S000001315|Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YGR280C	5.37442	YDR026c	YGR280C|PXR1|S000003512|Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YKR012C	5.35401	YDR026c	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YGR195W	5.34565	YDR026c	YGR195W|SKI6|S000003427|3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YGR145W	5.32366	YDR026c	YGR145W|ENP2|S000003377|Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YBR257W	5.31298	YDR026c	YBR257W|POP4|S000000461|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YLR196W	5.3091	YDR026c	YLR196W|PWP1|S000004186|Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YLR413W	5.24077	YDR026c	YLR413W||S000004405|Putative protein of unknown function; YLR413W is not an essential gene
YDL075W	5.23042	YDR026c	YDL075W|RPL31A|S000002233|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YPL178W	5.1896	YDR026c	YPL178W|CBC2|S000006099|Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YER130C	5.17228	YDR026c	YER130C||S000000932|Hypothetical protein
YDR072C	5.1674	YDR026c	YDR072C|IPT1|S000002479|Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YLR132C	5.16292	YDR026c	YLR132C||S000004122|Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YNL065W	5.14605	YDR026c	YNL065W|AQR1|S000005009|Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YDR382W	5.1074	YDR026c	YDR382W|RPP2B|S000002790|Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YGL209W	5.10295	YDR026c	YGL209W|MIG2|S000003177|Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YPL141C	5.01668	YDR026c	YPL141C||S000006062|Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YDR257C	4.99019	YDR026c	YDR257C|SET7|S000002665|Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins
YLL008W	4.97779	YDR026c	YLL008W|DRS1|S000003931|Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YPR074W-A	4.97147	YDR026c	YPR074W-A||S000007631|Hypothetical protein identified by homology
YKR075C	4.94085	YDR026c	YKR075C||S000001783|Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YPR163C	4.93384	YDR026c	YPR163C|TIF3|S000006367|Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YMR121C	4.92858	YDR026c	YMR121C|RPL15B|S000004728|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YJL090C	4.90949	YDR026c	YJL090C|DPB11|S000003626|Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
YDR101C	4.87992	YDR026c	YDR101C|ARX1|S000002508|Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YFR054C	4.87416	YDR026c	YFR054C||S000001950|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL009C-A	4.85068	YDR026c	YIL009C-A|EST3|S000006432|Component of the telomerase holoenzyme, involved in telomere replication
YBR164C	4.84458	YDR026c	YBR164C|ARL1|S000000368|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YOR025W	4.84079	YDR026c	YOR025W|HST3|S000005551|Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YLR197W	4.80976	YDR026c	YLR197W|SIK1|S000004187|Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YHR203C	4.79607	YDR026c	YHR203C|RPS4B|S000001246|Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YJR010W	4.7944	YDR026c	YJR010W|MET3|S000003771|ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YOR271C	4.76829	YDR026c	YOR271C|FSF1|S000005797|Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YDR147W	4.75006	YDR026c	YDR147W|EKI1|S000002554|Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
YOL031C	4.72325	YDR026c	YOL031C|SIL1|S000005391|Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YBL044W	4.71202	YDR026c	YBL044W||S000000140|Putative protein of unknown function; YBL044W is not an essential protein
YDR095C	4.69603	YDR026c	YDR095C||S000002502|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR130C	4.68171	YDR026c	YBR130C|SHE3|S000000334|Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YGR037C	4.61841	YDR026c	YGR037C|ACB1|S000003269|Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YDR094W	4.61623	YDR026c	YDR094W||S000002501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YDR037W	4.60954	YDR026c	YDR037W|KRS1|S000002444|Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YLR328W	4.58794	YDR026c	YLR328W|NMA1|S000004320|Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YML119W	4.58606	YDR026c	YML119W||S000004588|Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YOR157C	4.58167	YDR026c	YOR157C|PUP1|S000005683|Endopeptidase with trypsin-like activity that cleaves after basic residues; beta 2 subunit of 20S proteasome, synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YML024W	4.57866	YDR026c	YML024W|RPS17A|S000004486|Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YJR003C	4.56657	YDR026c	YJR003C||S000003763|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL023C	4.56006	YDR026c	YDL023C||S000002181|Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YPR148C	4.55321	YDR026c	YPR148C||S000006352|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL009C	4.54275	YDR026c	YGL009C|LEU1|S000002977|Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YGR251W	4.52892	YDR026c	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YGR285C	4.52569	YDR026c	YGR285C|ZUO1|S000003517|Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YFL016C	4.50042	YDR026c	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YFL037W	4.48089	YDR026c	YFL037W|TUB2|S000001857|Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YGL202W	4.4724	YDR026c	YGL202W|ARO8|S000003170|Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YGR051C	4.39807	YDR026c	YGR051C||S000003283|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YOL101C	4.37538	YDR026c	YOL101C|IZH4|S000005461|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YMR281W	4.30268	YDR026c	YMR281W|GPI12|S000004894|ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YPL266W	4.27598	YDR026c	YPL266W|DIM1|S000006187|Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YNL075W	4.23424	YDR026c	YNL075W|IMP4|S000005019|Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YKL110C	4.23277	YDR026c	YKL110C|KTI12|S000001593|Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YDL226C	4.23154	YDR026c	YDL226C|GCS1|S000002385|ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YOR046C	4.21504	YDR026c	YOR046C|DBP5|S000005572|Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
YER009W	4.21191	YDR026c	YER009W|NTF2|S000000811|Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YJR076C	4.20597	YDR026c	YJR076C|CDC11|S000003837|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YOR243C	4.20459	YDR026c	YOR243C|PUS7|S000005769|Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YBR256C	4.19528	YDR026c	YBR256C|RIB5|S000000460|Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YBL063W	4.15925	YDR026c	YBL063W|KIP1|S000000159|Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YML001W	4.13812	YDR026c	YML001W|YPT7|S000004460|GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
YOR299W	4.12973	YDR026c	YOR299W|BUD7|S000005825|Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YOL085C	4.10631	YDR026c	YOL085C||S000005445|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YHR127W	4.09955	YDR026c	YHR127W||S000001169|Protein of unknown function; localizes to the nucleus
YEL051W	4.09904	YDR026c	YEL051W|VMA8|S000000777|Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YOR265W	4.09699	YDR026c	YOR265W|RBL2|S000005791|Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A
YLR083C	4.08718	YDR026c	YLR083C|EMP70|S000004073|Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YNR013C	4.07089	YDR026c	YNR013C|PHO91|S000005296|Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YGR078C	4.06938	YDR026c	YGR078C|PAC10|S000003310|Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YGR094W	4.06293	YDR026c	YGR094W|VAS1|S000003326|Mitochondrial and cytoplasmic valyl-tRNA synthetase
YKL122C	4.05747	YDR026c	YKL122C|SRP21|S000001605|Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YHL020C	4.05321	YDR026c	YHL020C|OPI1|S000001012|Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YBL076C	4.04345	YDR026c	YBL076C|ILS1|S000000172|Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YDL112W	4.0354	YDR026c	YDL112W|TRM3|S000002270|2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YIL169C	4.01305	YDR026c	YIL169C||S000001431|Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YBR112C	4.00821	YDR026c	YBR112C|CYC8|S000000316|General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YDR465C	3.99471	YDR026c	YDR465C|RMT2|S000002873|Arginine methyltransferase; ribosomal protein L12 is a substrate
YCR006C	3.9744	YDR026c	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR091C	3.96357	YDR026c	YDR091C|RLI1|S000002498|Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YJL138C	3.96078	YDR026c	YJL138C|TIF2|S000003674|Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YMR011W	3.92572	YDR026c	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YBR158W	3.91026	YDR026c	YBR158W|AMN1|S000000362|Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YDL040C	3.89935	YDR026c	YDL040C|NAT1|S000002198|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YGR025W	3.87817	YDR026c	YGR025W||S000003257|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL055W	3.86656	YDR026c	YGL055W|OLE1|S000003023|Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YNL301C	3.8608	YDR026c	YNL301C|RPL18B|S000005245|Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YLR262C	3.85838	YDR026c	YLR262C|YPT6|S000004252|GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YDL022W	3.85197	YDR026c	YDL022W|GPD1|S000002180|NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YCL058C	3.84762	YDR026c	YCL058C|FYV5|S000000563|Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YDL055C	3.82009	YDR026c	YDL055C|PSA1|S000002213|GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YOL092W	3.81549	YDR026c	YOL092W||S000005452|Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype
YMR205C	3.8085	YDR026c	YMR205C|PFK2|S000004818|Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YBL003C	3.80507	YDR026c	YBL003C|HTA2|S000000099|One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YDR190C	3.78059	YDR026c	YDR190C|RVB1|S000002598|Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YOR342C	3.77252	YDR026c	YOR342C||S000005869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YOL038W	3.77019	YDR026c	YOL038W|PRE6|S000005398|Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YHR180W-A	3.76258	YDR026c	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YNL169C	3.76081	YDR026c	YNL169C|PSD1|S000005113|Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YPR051W	3.75756	YDR026c	YPR051W|MAK3|S000006255|Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YDL213C	3.73495	YDR026c	YDL213C|NOP6|S000002372|Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YIL119C	3.72067	YDR026c	YIL119C|RPI1|S000001381|Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YEL020C-B	3.70295	YDR026c	YEL020C-B||S000028544|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YER091C	3.69142	YDR026c	YER091C|MET6|S000000893|Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YNL069C	3.67618	YDR026c	YNL069C|RPL16B|S000005013|N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YOL049W	3.67475	YDR026c	YOL049W|GSH2|S000005409|Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YDL187C	3.66098	YDR026c	YDL187C||S000002346|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL040C	3.65845	YDR026c	YGL040C|HEM2|S000003008|Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YML053C	3.60647	YDR026c	YML053C||S000004517|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene
YJR145C	3.60423	YDR026c	YJR145C|RPS4A|S000003906|Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YER136W	3.58792	YDR026c	YER136W|GDI1|S000000938|GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YNL132W	3.58573	YDR026c	YNL132W|KRE33|S000005076|Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YEL027W	3.5742	YDR026c	YEL027W|CUP5|S000000753|Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YPR038W	3.57159	YDR026c	YPR038W|IRC16|S000006242|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci
YMR214W	3.51329	YDR026c	YMR214W|SCJ1|S000004827|One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
YDR073W	3.51183	YDR026c	YDR073W|SNF11|S000002480|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YGR249W	3.50839	YDR026c	YGR249W|MGA1|S000003481|Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YHR183W	3.50716	YDR026c	YHR183W|GND1|S000001226|6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YDL022C-A	3.50182	YDR026c	YDL022C-A||S000028537|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YOR340C	3.48963	YDR026c	YOR340C|RPA43|S000005867|RNA polymerase I subunit A43
YER134C	3.48771	YDR026c	YER134C||S000000936|Putative protein of unknown function; non-essential gene
YDR161W	3.48748	YDR026c	YDR161W||S000002568|Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation
YJL111W	3.48102	YDR026c	YJL111W|CCT7|S000003647|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YER118C	3.47587	YDR026c	YER118C|SHO1|S000000920|Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YMR072W	3.47189	YDR026c	YMR072W|ABF2|S000004676|Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
YDR278C	3.46703	YDR026c	YDR278C||S000002686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL031W	3.46496	YDR026c	YDL031W|DBP10|S000002189|Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YJL196C	3.46431	YDR026c	YJL196C|ELO1|S000003732|Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YDR496C	3.45281	YDR026c	YDR496C|PUF6|S000002904|Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA
YHR182C-A	3.44576	YDR026c	YHR182C-A||S000028784|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR017C	3.44449	YDR026c	YBR017C|KAP104|S000000221|Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression
YLR351C	3.42333	YDR026c	YLR351C|NIT3|S000004343|Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YDR450W	3.41844	YDR026c	YDR450W|RPS18A|S000002858|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YBR066C	3.41512	YDR026c	YBR066C|NRG2|S000000270|Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YBR171W	3.40937	YDR026c	YBR171W|SEC66|S000000375|Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YLL027W	3.40376	YDR026c	YLL027W|ISA1|S000003950|Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YKL080W	3.39956	YDR026c	YKL080W|VMA5|S000001563|Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YDL132W	3.38611	YDR026c	YDL132W|CDC53|S000002290|Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YHR170W	3.37242	YDR026c	YHR170W|NMD3|S000001213|Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YNL118C	3.35	YDR026c	YNL118C|DCP2|S000005062|Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YOR133W	3.34934	YDR026c	YOR133W|EFT1|S000005659|Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YIL121W	3.34104	YDR026c	YIL121W|QDR2|S000001383|Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YML102W	3.33373	YDR026c	YML102W|CAC2|S000004570|Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
YFR002W	3.32532	YDR026c	YFR002W|NIC96|S000001898|Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
YPL019C	3.32233	YDR026c	YPL019C|VTC3|S000005940|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YIR013C	3.29928	YDR026c	YIR013C|GAT4|S000001452|Protein containing GATA family zinc finger motifs
YER025W	3.28537	YDR026c	YER025W|GCD11|S000000827|Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YEL029C	3.27015	YDR026c	YEL029C|BUD16|S000000755|Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YPR035W	3.25882	YDR026c	YPR035W|GLN1|S000006239|Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YER070W	3.22932	YDR026c	YER070W|RNR1|S000000872|One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YLL012W	3.22626	YDR026c	YLL012W|YEH1|S000003935|Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YLR042C	3.2144	YDR026c	YLR042C||S000004032|Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YPR037C	3.20411	YDR026c	YPR037C|ERV2|S000006241|Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
YOR198C	3.19555	YDR026c	YOR198C|BFR1|S000005724|Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
YLR285W	3.17798	YDR026c	YLR285W|NNT1|S000004275|Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YBR113W	3.16115	YDR026c	YBR113W||S000000317|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YMR091C	3.13289	YDR026c	YMR091C|NPL6|S000004697|Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length
YLR026C	3.11065	YDR026c	YLR026C|SED5|S000004016|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YOR273C	3.08239	YDR026c	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YGL244W	3.07087	YDR026c	YGL244W|RTF1|S000003213|Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
YGR156W	3.04876	YDR026c	YGR156W|PTI1|S000003388|Pta1p Interacting protein
YML075C	3.04004	YDR026c	YML075C|HMG1|S000004540|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YDR451C	3.0301	YDR026c	YDR451C|YHP1|S000002859|One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YKR035W-A	3.00897	YDR026c	YKR035W-A|DID2|S000006435|Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
YHR167W	2.99322	YDR026c	YHR167W|THP2|S000001210|Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
YCR072C	2.99093	YDR026c	YCR072C|RSA4|S000000668|WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YGR179C	2.99035	YDR026c	YGR179C|OKP1|S000003411|Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YDR412W	2.98588	YDR026c	YDR412W|RRP17|S000002820|Component of the pre-60S pre-ribosomal particle; required for cell viability
YGR113W	2.94643	YDR026c	YGR113W|DAM1|S000003345|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
YOR021C	2.9428	YDR026c	YOR021C||S000005547|Putative protein of unknown function; YOR021C is not an essential gene
YBL002W	2.92958	YDR026c	YBL002W|HTB2|S000000098|One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YMR117C	2.92413	YDR026c	YMR117C|SPC24|S000004723|Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YFL005W	2.92005	YDR026c	YFL005W|SEC4|S000001889|Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YDR050C	2.9134	YDR026c	YDR050C|TPI1|S000002457|Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YDL137W	2.91251	YDR026c	YDL137W|ARF2|S000002296|ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p
YKR094C	2.90595	YDR026c	YKR094C|RPL40B|S000001802|Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YGR135W	2.89536	YDR026c	YGR135W|PRE9|S000003367|Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
YPR041W	2.85665	YDR026c	YPR041W|TIF5|S000006245|Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation
YMR144W	2.84202	YDR026c	YMR144W||S000004752|Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YPR025C	2.81435	YDR026c	YPR025C|CCL1|S000006229|Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
YOL080C	2.8105	YDR026c	YOL080C|REX4|S000005440|Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YKL072W	2.79944	YDR026c	YKL072W|STB6|S000001555|Protein that binds Sin3p in a two-hybrid assay
YIL039W	2.79655	YDR026c	YIL039W|TED1|S000001301|Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YJR065C	2.79631	YDR026c	YJR065C|ARP3|S000003826|Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YPL225W	2.7948	YDR026c	YPL225W||S000006146|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR234C	2.79222	YDR026c	YOR234C|RPL33B|S000005760|Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YNL096C	2.78495	YDR026c	YNL096C|RPS7B|S000005040|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YGR214W	2.78098	YDR026c	YGR214W|RPS0A|S000003446|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YLR180W	2.75493	YDR026c	YLR180W|SAM1|S000004170|S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YGR027C	2.73277	YDR026c	YGR027C|RPS25A|S000003259|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YEL056W	2.70546	YDR026c	YEL056W|HAT2|S000000782|Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YMR305C	2.69626	YDR026c	YMR305C|SCW10|S000004921|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YOR335C	2.68216	YDR026c	YOR335C|ALA1|S000005862|Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YOL079W	2.67853	YDR026c	YOL079W||S000005439|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR099W	2.6785	YDR026c	YDR099W|BMH2|S000002506|14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YDL163W	2.6592	YDR026c	YDL163W||S000002322|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
YGR287C	2.64975	YDR026c	YGR287C||S000003519|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YNR017W	2.64291	YDR026c	YNR017W|TIM23|S000005300|Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YDR153C	2.62559	YDR026c	YDR153C|ENT5|S000002560|Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YKR074W	2.62368	YDR026c	YKR074W|AIM29|S000001782|Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDR498C	2.62284	YDR026c	YDR498C|SEC20|S000002906|Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p
YDR133C	2.61986	YDR026c	YDR133C||S000002540|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOR096W	2.56395	YDR026c	YOR096W|RPS7A|S000005622|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YDL164C	2.55813	YDR026c	YDL164C|CDC9|S000002323|DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YFR051C	2.54817	YDR026c	YFR051C|RET2|S000001947|Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YOR094W	2.53028	YDR026c	YOR094W|ARF3|S000005620|Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity
YGL012W	2.52333	YDR026c	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YOR013W	2.52038	YDR026c	YOR013W|IRC11|S000005539|Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YDR016C	2.51219	YDR026c	YDR016C|DAD1|S000002423|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YGR026W	2.50148	YDR026c	YGR026W||S000003258|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YLR206W	2.49943	YDR026c	YLR206W|ENT2|S000004196|Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YHR026W	2.47705	YDR026c	YHR026W|PPA1|S000001068|Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
YJL124C	2.47102	YDR026c	YJL124C|LSM1|S000003660|Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
YJR126C	2.4707	YDR026c	YJR126C|VPS70|S000003887|Protein of unknown function involved in vacuolar protein sorting
YDL135C	2.45898	YDR026c	YDL135C|RDI1|S000002294|Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
YBL040C	2.44987	YDR026c	YBL040C|ERD2|S000000136|HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YKL190W	2.4469	YDR026c	YKL190W|CNB1|S000001673|Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YER021W	2.44078	YDR026c	YER021W|RPN3|S000000823|Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YGL189C	2.4314	YDR026c	YGL189C|RPS26A|S000003157|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
YOR287C	2.42437	YDR026c	YOR287C||S000005813|Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype
YOR074C	2.40675	YDR026c	YOR074C|CDC21|S000005600|Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YLR254C	2.39942	YDR026c	YLR254C|NDL1|S000004244|Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
YJL105W	2.39236	YDR026c	YJL105W|SET4|S000003641|Protein of unknown function, contains a SET domain
YGR245C	2.39018	YDR026c	YGR245C|SDA1|S000003477|Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YGR054W	2.38432	YDR026c	YGR054W||S000003286|Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
YOR274W	2.37832	YDR026c	YOR274W|MOD5|S000005800|Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YMR221C	2.37545	YDR026c	YMR221C|FMP42|S000004834|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
YHR023W	2.37152	YDR026c	YHR023W|MYO1|S000001065|Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
YDR208W	2.35469	YDR026c	YDR208W|MSS4|S000002616|Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
YGR218W	2.3524	YDR026c	YGR218W|CRM1|S000003450|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
YNL300W	2.34905	YDR026c	YNL300W||S000005244|Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YEL038W	2.3475	YDR026c	YEL038W|UTR4|S000000764|Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus
YOR073W-A	2.34685	YDR026c	YOR073W-A||S000028583|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YDR303C	2.33895	YDR026c	YDR303C|RSC3|S000002711|Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YBL058W	2.33786	YDR026c	YBL058W|SHP1|S000000154|UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
YDL225W	2.32692	YDR026c	YDL225W|SHS1|S000002384|One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
YLR262C-A	2.32262	YDR026c	YLR262C-A|TMA7|S000007246|Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
YGL178W	2.31829	YDR026c	YGL178W|MPT5|S000003146|Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YGL070C	2.31829	YDR026c	YGL070C|RPB9|S000003038|RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
YDL186W	2.31417	YDR026c	YDL186W||S000002345|Putative protein of unknown function; YDL186W is not an essential gene
YJL008C	2.31057	YDR026c	YJL008C|CCT8|S000003545|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YMR082C	2.29638	YDR026c	YMR082C||S000004687|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR156W	2.28779	YDR026c	YDR156W|RPA14|S000002563|RNA polymerase I subunit A14
YBR091C	2.28327	YDR026c	YBR091C|MRS5|S000000295|Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
YGL137W	2.27905	YDR026c	YGL137W|SEC27|S000003105|Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YER135C	2.27642	YDR026c	YER135C||S000000937|Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
YGL088W	2.26971	YDR026c	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YDL173W	2.25327	YDR026c	YDL173W||S000002332|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene
YIL056W	2.25152	YDR026c	YIL056W|VHR1|S000001318|Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YKL062W	2.24658	YDR026c	YKL062W|MSN4|S000001545|Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YER055C	2.2458	YDR026c	YER055C|HIS1|S000000857|ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YML082W	2.24064	YDR026c	YML082W||S000004547|Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YPL144W	2.23836	YDR026c	YPL144W|POC4|S000006065|Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YEL026W	2.23278	YDR026c	YEL026W|SNU13|S000000752|RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YNL338W	2.23132	YDR026c	YNL338W||S000005282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YJR047C	2.20307	YDR026c	YJR047C|ANB1|S000003808|Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YHR154W	2.19848	YDR026c	YHR154W|RTT107|S000001197|Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YPL215W	2.19834	YDR026c	YPL215W|CBP3|S000006136|Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p
YOR349W	2.17762	YDR026c	YOR349W|CIN1|S000005876|Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
YDR052C	2.17757	YDR026c	YDR052C|DBF4|S000002459|Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated
YMR102C	2.17091	YDR026c	YMR102C||S000004708|Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YLL021W	2.16587	YDR026c	YLL021W|SPA2|S000003944|Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YPR156C	2.1644	YDR026c	YPR156C|TPO3|S000006360|Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YBR192W	2.16088	YDR026c	YBR192W|RIM2|S000000396|Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YKR079C	2.15529	YDR026c	YKR079C|TRZ1|S000001787|tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YNL280C	2.1551	YDR026c	YNL280C|ERG24|S000005224|C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YDR172W	2.15079	YDR026c	YDR172W|SUP35|S000002579|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype
YBR078W	2.13967	YDR026c	YBR078W|ECM33|S000000282|GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YBL024W	2.12804	YDR026c	YBL024W|NCL1|S000000120|S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YCR034W	2.12605	YDR026c	YCR034W|FEN1|S000000630|Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YKL145W	2.118	YDR026c	YKL145W|RPT1|S000001628|One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p
YOL021C	2.11622	YDR026c	YOL021C|DIS3|S000005381|Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family
YER074W	2.1161	YDR026c	YER074W|RPS24A|S000000876|Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YGR090W	2.11027	YDR026c	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YKR093W	2.1055	YDR026c	YKR093W|PTR2|S000001801|Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YDR519W	2.09959	YDR026c	YDR519W|FPR2|S000002927|Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking
YEL014C	2.09307	YDR026c	YEL014C||S000000740|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR153C	2.07558	YDR026c	YHR153C|SPO16|S000001196|Protein of unknown function, required for spore formation
YER063W	2.06677	YDR026c	YER063W|THO1|S000000865|Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
YOR011W	2.0605	YDR026c	YOR011W|AUS1|S000005537|Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YPL001W	2.05023	YDR026c	YPL001W|HAT1|S000005922|Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
YPL010W	2.03677	YDR026c	YPL010W|RET3|S000005931|Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YDL029W	2.03351	YDR026c	YDL029W|ARP2|S000002187|Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YGR116W	2.02939	YDR026c	YGR116W|SPT6|S000003348|Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
YDR228C	2.02727	YDR026c	YDR228C|PCF11|S000002636|mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
YJR007W	2.02643	YDR026c	YJR007W|SUI2|S000003767|Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
YGL161C	2.02399	YDR026c	YGL161C|YIP5|S000003129|Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YNL229C	2.01879	YDR026c	YNL229C|URE2|S000005173|Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
YGR130C	2.01879	YDR026c	YGR130C||S000003362|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YKL008C	2.01668	YDR026c	YKL008C|LAC1|S000001491|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YGL200C	2.01359	YDR026c	YGL200C|EMP24|S000003168|Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YKL052C	1.99885	YDR026c	YKL052C|ASK1|S000001535|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YER048C	1.99613	YDR026c	YER048C|CAJ1|S000000850|Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YLR401C	1.97309	YDR026c	YLR401C|DUS3|S000004393|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YAR071W	1.96927	YDR026c	YAR071W|PHO11|S000000094|One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YMR024W	1.96687	YDR026c	YMR024W|MRPL3|S000004626|Mitochondrial ribosomal protein of the large subunit
YHR208W	1.96137	YDR026c	YHR208W|BAT1|S000001251|Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YER064C	1.95881	YDR026c	YER064C||S000000866|Non-essential nuclear protein; null mutation has global effects on transcription
YML069W	1.95656	YDR026c	YML069W|POB3|S000004534|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
YBL070C	1.95016	YDR026c	YBL070C||S000000166|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR044W	1.94789	YDR026c	YDR044W|HEM13|S000002451|Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YOR352W	1.92611	YDR026c	YOR352W||S000005879|Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR215C	1.92345	YDR026c	YDR215C||S000002623|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YEL055C	1.91618	YDR026c	YEL055C|POL5|S000000781|DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YBR049C	1.90794	YDR026c	YBR049C|REB1|S000000253|RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
YIL062C	1.88826	YDR026c	YIL062C|ARC15|S000001324|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YNL287W	1.88173	YDR026c	YNL287W|SEC21|S000005231|Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
YOR008C-A	1.87631	YDR026c	YOR008C-A||S000006431|Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YEL034C-A	1.87136	YDR026c	YEL034C-A||S000028743|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YJL200C	1.8612	YDR026c	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YMR122W-A	1.84309	YDR026c	YMR122W-A||S000007524|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YML063W	1.84198	YDR026c	YML063W|RPS1B|S000004528|Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YJL035C	1.83066	YDR026c	YJL035C|TAD2|S000003572|Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YAL038W	1.82345	YDR026c	YAL038W|CDC19|S000000036|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YMR012W	1.82093	YDR026c	YMR012W|CLU1|S000004614|eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YGL245W	1.81826	YDR026c	YGL245W|GUS1|S000003214|Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
YPL155C	1.81585	YDR026c	YPL155C|KIP2|S000006076|Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
YHR007C	1.8106	YDR026c	YHR007C|ERG11|S000001049|Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YHL029C	1.80418	YDR026c	YHL029C|OCA5|S000001021|Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YDR499W	1.80377	YDR026c	YDR499W|LCD1|S000002907|Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP
YDR207C	1.78918	YDR026c	YDR207C|UME6|S000002615|Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YDR025W	1.778	YDR026c	YDR025W|RPS11A|S000002432|Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YMR318C	1.77744	YDR026c	YMR318C|ADH6|S000004937|NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YMR049C	1.76296	YDR026c	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YNR018W	1.75617	YDR026c	YNR018W|AIM38|S000005301|Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YFL014W	1.75275	YDR026c	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YLR349W	1.75238	YDR026c	YLR349W||S000004341|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YJR123W	1.75193	YDR026c	YJR123W|RPS5|S000003884|Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YER087C-B	1.74801	YDR026c	YER087C-B|SBH1|S000002128|Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p
YLL031C	1.74107	YDR026c	YLL031C|GPI13|S000003954|ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YDL212W	1.73349	YDR026c	YDL212W|SHR3|S000002371|Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YLR110C	1.72885	YDR026c	YLR110C|CCW12|S000004100|Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YIL011W	1.72764	YDR026c	YIL011W|TIR3|S000001273|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YOR332W	1.72599	YDR026c	YOR332W|VMA4|S000005859|Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YGR083C	1.72128	YDR026c	YGR083C|GCD2|S000003315|Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YNR001W-A	1.71263	YDR026c	YNR001W-A||S000007625|Dubious open reading frame unlikely to encode a functional protein; identified by homology
YLL022C	1.71093	YDR026c	YLL022C|HIF1|S000003945|Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing
YBR127C	1.7072	YDR026c	YBR127C|VMA2|S000000331|Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm
YBR198C	1.70559	YDR026c	YBR198C|TAF5|S000000402|Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YOL012C	1.70127	YDR026c	YOL012C|HTZ1|S000005372|Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YPL047W	1.69383	YDR026c	YPL047W|SGF11|S000005968|Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
YER048W-A	1.69165	YDR026c	YER048W-A|ISD11|S000007237|Protein required for mitochondrial iron-sulfur cluster biosynthesis
YJL194W	1.69048	YDR026c	YJL194W|CDC6|S000003730|Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
YLR348C	1.68815	YDR026c	YLR348C|DIC1|S000004340|Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YHR076W	1.67942	YDR026c	YHR076W|PTC7|S000001118|Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YPL235W	1.67039	YDR026c	YPL235W|RVB2|S000006156|Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YPL169C	1.65972	YDR026c	YPL169C|MEX67|S000006090|Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
YBR092C	1.65851	YDR026c	YBR092C|PHO3|S000000296|Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YKL051W	1.65601	YDR026c	YKL051W|SFK1|S000001534|Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YBL069W	1.656	YDR026c	YBL069W|AST1|S000000165|Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
YLR093C	1.65197	YDR026c	YLR093C|NYV1|S000004083|v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
YGR001C	1.65048	YDR026c	YGR001C|AML1|S000003233|Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
YEL053C	1.63643	YDR026c	YEL053C|MAK10|S000000779|Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YHR013C	1.63168	YDR026c	YHR013C|ARD1|S000001055|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YLR227C	1.62613	YDR026c	YLR227C|ADY4|S000004217|Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YIL128W	1.62453	YDR026c	YIL128W|MET18|S000001390|DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
YDR053W	1.61595	YDR026c	YDR053W||S000002460|Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
YPR062W	1.61522	YDR026c	YPR062W|FCY1|S000006266|Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YPR144C	1.61247	YDR026c	YPR144C|NOC4|S000006348|Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YML127W	1.60948	YDR026c	YML127W|RSC9|S000004596|Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YCR012W	1.60932	YDR026c	YCR012W|PGK1|S000000605|3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YAL029C	1.60626	YDR026c	YAL029C|MYO4|S000000027|One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YGR267C	1.59325	YDR026c	YGR267C|FOL2|S000003499|GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
YKL113C	1.59035	YDR026c	YKL113C|RAD27|S000001596|5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YGR202C	1.58227	YDR026c	YGR202C|PCT1|S000003434|Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding
YJL002C	1.5575	YDR026c	YJL002C|OST1|S000003539|Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YDR170C	1.54314	YDR026c	YDR170C|SEC7|S000002577|Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YNL162W	1.541	YDR026c	YNL162W|RPL42A|S000005106|Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YGR131W	1.51991	YDR026c	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YLR224W	1.51804	YDR026c	YLR224W||S000004214|F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YMR320W	1.50901	YDR026c	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR158W	1.5064	YDR026c	YOR158W|PET123|S000005684|Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
YEL013W	1.50429	YDR026c	YEL013W|VAC8|S000000739|Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
YLR133W	1.49493	YDR026c	YLR133W|CKI1|S000004123|Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
YMR146C	1.48801	YDR026c	YMR146C|TIF34|S000004754|Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YGL151W	1.48675	YDR026c	YGL151W|NUT1|S000003119|Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
YER159C	1.48541	YDR026c	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YGL247W	1.48438	YDR026c	YGL247W|BRR6|S000003216|Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores
YPL145C	1.4807	YDR026c	YPL145C|KES1|S000006066|Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
YNL304W	1.45322	YDR026c	YNL304W|YPT11|S000005248|Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells
YNL182C	1.4527	YDR026c	YNL182C|IPI3|S000005126|Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YDR028C	1.45133	YDR026c	YDR028C|REG1|S000002435|Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
YHR039C-A	1.44803	YDR026c	YHR039C-A|VMA10|S000002100|Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification
YNL320W	1.44065	YDR026c	YNL320W||S000005264|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR174W	1.43825	YDR026c	YDR174W|HMO1|S000002581|Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YIL076W	1.43733	YDR026c	YIL076W|SEC28|S000001338|Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YDR152W	1.42699	YDR026c	YDR152W|GIR2|S000002559|Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YDR240C	1.41838	YDR026c	YDR240C|SNU56|S000002648|Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YOR108C-A	1.405	YDR026c	YOR108C-A||S000028711|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR424C	1.39501	YDR026c	YDR424C|DYN2|S000002832|Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
YMR016C	1.3942	YDR026c	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YNL087W	1.39001	YDR026c	YNL087W|TCB2|S000005031|Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
YCR095C	1.38562	YDR026c	YCR095C|OCA4|S000000691|Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YGL206C	1.38486	YDR026c	YGL206C|CHC1|S000003174|Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
YMR212C	1.38454	YDR026c	YMR212C|EFR3|S000004825|Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylated
YNL032W	1.38351	YDR026c	YNL032W|SIW14|S000004977|Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
YDR449C	1.38294	YDR026c	YDR449C|UTP6|S000002857|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGL182C	1.38292	YDR026c	YGL182C||S000003150|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C
YMR296C	1.38241	YDR026c	YMR296C|LCB1|S000004911|Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YLR011W	1.3795	YDR026c	YLR011W|LOT6|S000004001|FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YGL253W	1.3789	YDR026c	YGL253W|HXK2|S000003222|Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YLR208W	1.36856	YDR026c	YLR208W|SEC13|S000004198|Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles
YML085C	1.34314	YDR026c	YML085C|TUB1|S000004550|Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
YPR014C	1.34116	YDR026c	YPR014C||S000006218|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YGR253C	1.33873	YDR026c	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YLR400W	1.32894	YDR026c	YLR400W||S000004392|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR088C	1.32658	YDR026c	YDR088C|SLU7|S000002495|RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YDL084W	1.31866	YDR026c	YDL084W|SUB2|S000002242|Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YLR033W	1.31221	YDR026c	YLR033W|RSC58|S000004023|Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance58KDa subunit
YJR066W	1.31043	YDR026c	YJR066W|TOR1|S000003827|PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
YML088W	1.30942	YDR026c	YML088W|UFO1|S000004553|F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YIR004W	1.30336	YDR026c	YIR004W|DJP1|S000001443|Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
YDR331W	1.30145	YDR026c	YDR331W|GPI8|S000002739|ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YJL076W	1.2962	YDR026c	YJL076W|NET1|S000003612|Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
YAL053W	1.2932	YDR026c	YAL053W|FLC2|S000000049|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YGR192C	1.29202	YDR026c	YGR192C|TDH3|S000003424|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YMR099C	1.2898	YDR026c	YMR099C||S000004705|Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YDR385W	1.28628	YDR026c	YDR385W|EFT2|S000002793|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YGR024C	1.27895	YDR026c	YGR024C|THG1|S000003256|tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
YJL198W	1.27864	YDR026c	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YDR292C	1.27592	YDR026c	YDR292C|SRP101|S000002700|Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
YOL144W	1.26435	YDR026c	YOL144W|NOP8|S000005504|Nucleolar protein required for 60S ribosomal subunit biogenesis
YGL246C	1.26107	YDR026c	YGL246C|RAI1|S000003215|Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing
YER176W	1.26005	YDR026c	YER176W|ECM32|S000000978|DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
YBL036C	1.25439	YDR026c	YBL036C||S000000132|Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YOL011W	1.25405	YDR026c	YOL011W|PLB3|S000005371|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YDR274C	1.25124	YDR026c	YDR274C||S000002682|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL106W	1.2503	YDR026c	YIL106W|MOB1|S000001368|Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
YOR107W	1.24972	YDR026c	YOR107W|RGS2|S000005633|Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YKL209C	1.249	YDR026c	YKL209C|STE6|S000001692|Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YPL177C	1.24828	YDR026c	YPL177C|CUP9|S000006098|Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YKL007W	1.23405	YDR026c	YKL007W|CAP1|S000001490|Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YJL033W	1.22944	YDR026c	YJL033W|HCA4|S000003570|Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YEL033W	1.22591	YDR026c	YEL033W|MTC7|S000000759|Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YLR099W-A	1.22584	YDR026c	YLR099W-A||S000007618|Putative protein of unknown function
YMR093W	1.22066	YDR026c	YMR093W|UTP15|S000004699|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDL043C	1.20642	YDR026c	YDL043C|PRP11|S000002201|Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YOR122C	1.20001	YDR026c	YOR122C|PFY1|S000005648|Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol
YBL052C	1.19795	YDR026c	YBL052C|SAS3|S000000148|Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality
YMR307W	1.19364	YDR026c	YMR307W|GAS1|S000004924|Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YGR034W	1.18626	YDR026c	YGR034W|RPL26B|S000003266|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YPR181C	1.17218	YDR026c	YPR181C|SEC23|S000006385|GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p
YDR309C	1.16811	YDR026c	YDR309C|GIC2|S000002717|Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YDR145W	1.16585	YDR026c	YDR145W|TAF12|S000002552|Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YJR099W	1.15491	YDR026c	YJR099W|YUH1|S000003860|Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YBR011C	1.15374	YDR026c	YBR011C|IPP1|S000000215|Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YER046W	1.1533	YDR026c	YER046W|SPO73|S000000848|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YBR028C	1.15119	YDR026c	YBR028C||S000000232|Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
YLR179C	1.1493	YDR026c	YLR179C||S000004169|Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YMR039C	1.14854	YDR026c	YMR039C|SUB1|S000004642|Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations
YBL012C	1.1474	YDR026c	YBL012C||S000000108|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR406C	1.14619	YDR026c	YLR406C|RPL31B|S000004398|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YJR097W	1.14328	YDR026c	YJR097W|JJJ3|S000003858|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YDR299W	1.13337	YDR026c	YDR299W|BFR2|S000002707|Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A
YLR171W	1.13214	YDR026c	YLR171W||S000004161|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL187C	1.13195	YDR026c	YJL187C|SWE1|S000003723|Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YJL153C	1.13157	YDR026c	YJL153C|INO1|S000003689|Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YLR453C	1.13077	YDR026c	YLR453C|RIF2|S000004445|Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YGR114C	1.12964	YDR026c	YGR114C||S000003346|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YLR282C	1.12091	YDR026c	YLR282C||S000004272|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
YOR151C	1.11594	YDR026c	YOR151C|RPB2|S000005677|RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
YDL076C	1.11409	YDR026c	YDL076C|RXT3|S000002234|Subunit of the RPD3L complex; involved in histone deacetylation
YBR079C	1.10216	YDR026c	YBR079C|RPG1|S000000283|Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YJR086W	1.10145	YDR026c	YJR086W|STE18|S000003846|G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
YIL074C	1.09775	YDR026c	YIL074C|SER33|S000001336|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YCR051W	1.09755	YDR026c	YCR051W||S000000647|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YNL058C	1.09498	YDR026c	YNL058C||S000005003|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YHR163W	1.09241	YDR026c	YHR163W|SOL3|S000001206|6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YPL255W	1.08587	YDR026c	YPL255W|BBP1|S000006176|Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YPL118W	1.08286	YDR026c	YPL118W|MRP51|S000006039|Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YBL083C	1.08283	YDR026c	YBL083C||S000000179|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
YJR133W	1.07472	YDR026c	YJR133W|XPT1|S000003894|Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
YGR138C	1.07337	YDR026c	YGR138C|TPO2|S000003370|Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YGR237C	1.0733	YDR026c	YGR237C||S000003469|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YHR083W	1.07076	YDR026c	YHR083W|SAM35|S000001125|Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YDR534C	1.06932	YDR026c	YDR534C|FIT1|S000002942|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGR079W	1.06914	YDR026c	YGR079W||S000003311|Putative protein of unknown function; YGR079W is not an essential gene
YPR092W	1.0646	YDR026c	YPR092W||S000006296|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR094C	1.06411	YDR026c	YJR094C|IME1|S000003854|Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YBR205W	1.06107	YDR026c	YBR205W|KTR3|S000000409|Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YOL030W	1.06008	YDR026c	YOL030W|GAS5|S000005390|1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YPL211W	1.05863	YDR026c	YPL211W|NIP7|S000006132|Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
YHL031C	1.05781	YDR026c	YHL031C|GOS1|S000001023|v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YER011W	1.05763	YDR026c	YER011W|TIR1|S000000813|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YDL188C	1.05318	YDR026c	YDL188C|PPH22|S000002347|Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YNL284C	1.0525	YDR026c	YNL284C|MRPL10|S000005228|Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
YNL016W	1.05248	YDR026c	YNL016W|PUB1|S000004961|Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YOR014W	1.04621	YDR026c	YOR014W|RTS1|S000005540|B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
YJL148W	1.04481	YDR026c	YJL148W|RPA34|S000003684|RNA polymerase I subunit A34.5
YPL170W	1.04265	YDR026c	YPL170W|DAP1|S000006091|Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YLR256W	1.04258	YDR026c	YLR256W|HAP1|S000004246|Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YJL004C	1.04054	YDR026c	YJL004C|SYS1|S000003541|Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
YPR126C	1.0344	YDR026c	YPR126C||S000006330|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR236C	1.03305	YDR026c	YBR236C|ABD1|S000000440|Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YKR001C	1.03243	YDR026c	YKR001C|VPS1|S000001709|Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
YHR141C	1.03149	YDR026c	YHR141C|RPL42B|S000001183|Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YER045C	1.02348	YDR026c	YER045C|ACA1|S000000847|Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YOR361C	1.02181	YDR026c	YOR361C|PRT1|S000005888|Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YBR175W	1.01804	YDR026c	YBR175W|SWD3|S000000379|Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
YGL135W	1.01798	YDR026c	YGL135W|RPL1B|S000003103|N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YBR199W	1.01373	YDR026c	YBR199W|KTR4|S000000403|Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YBR048W	1.01123	YDR026c	YBR048W|RPS11B|S000000252|Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YIL116W	1.01006	YDR026c	YIL116W|HIS5|S000001378|Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YBR174C	1.00815	YDR026c	YBR174C||S000000378|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
YOR108W	1.00185	YDR026c	YOR108W|LEU9|S000005634|Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YOR341W	0.999021	YDR026c	YOR341W|RPA190|S000005868|RNA polymerase I subunit; largest subunit of RNA polymerase I
YPR182W	0.998408	YDR026c	YPR182W|SMX3|S000006386|Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
YGR084C	0.986009	YDR026c	YGR084C|MRP13|S000003316|Mitochondrial ribosomal protein of the small subunit
YIL163C	0.98588	YDR026c	YIL163C||S000001425|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL004W	0.982749	YDR026c	YOL004W|SIN3|S000005364|Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
YMR100W	0.978047	YDR026c	YMR100W|MUB1|S000004706|Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene
YMR131C	0.974104	YDR026c	YMR131C|RRB1|S000004738|Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YKL153W	0.973365	YDR026c	YKL153W||S000001636|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YNL185C	0.972505	YDR026c	YNL185C|MRPL19|S000005129|Mitochondrial ribosomal protein of the large subunit
YGL038C	0.963403	YDR026c	YGL038C|OCH1|S000003006|Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
YPR039W	0.963382	YDR026c	YPR039W||S000006243|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
YOR320C	0.960307	YDR026c	YOR320C|GNT1|S000005847|N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
YMR153W	0.9577	YDR026c	YMR153W|NUP53|S000004762|Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex
YPL207W	0.95546	YDR026c	YPL207W|TYW1|S000006128|Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YEL062W	0.95416	YDR026c	YEL062W|NPR2|S000000788|Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin
YIL164C	0.951706	YDR026c	YIL164C|NIT1|S000001426|Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YGR140W	0.951657	YDR026c	YGR140W|CBF2|S000003372|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YLR274W	0.950018	YDR026c	YLR274W|MCM5|S000004264|Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YGL225W	0.949062	YDR026c	YGL225W|VRG4|S000003193|Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YJR092W	0.943884	YDR026c	YJR092W|BUD4|S000003852|Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate
YPR167C	0.943095	YDR026c	YPR167C|MET16|S000006371|3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
YLR162W-A	0.937654	YDR026c	YLR162W-A||S000028567|Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YNL057W	0.931723	YDR026c	YNL057W||S000005002|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL241C	0.929137	YDR026c	YPL241C|CIN2|S000006162|GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
YLR412W	0.926357	YDR026c	YLR412W|BER1|S000004404|Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
YGL207W	0.925319	YDR026c	YGL207W|SPT16|S000003175|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
YLR084C	0.924919	YDR026c	YLR084C|RAX2|S000004074|N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p
YNL099C	0.920809	YDR026c	YNL099C|OCA1|S000005043|Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
YIL149C	0.919124	YDR026c	YIL149C|MLP2|S000001411|Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
YDR480W	0.912687	YDR026c	YDR480W|DIG2|S000002888|Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YDR427W	0.904925	YDR026c	YDR427W|RPN9|S000002835|Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
YDR328C	0.904607	YDR026c	YDR328C|SKP1|S000002736|Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
YBR163W	0.904078	YDR026c	YBR163W|DEM1|S000000367|Mitochondrial protein of unknown function; null mutant has defects in cell morphology and in response to air drying; may be regulated by the transcription factor Ace2
YJL007C	0.899996	YDR026c	YJL007C||S000003544|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL148C	0.891722	YDR026c	YOL148C|SPT20|S000005508|Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex
YDL018C	0.888646	YDR026c	YDL018C|ERP3|S000002176|Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YMR076C	0.87968	YDR026c	YMR076C|PDS5|S000004681|Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold
YHR143W-A	0.878859	YDR026c	YHR143W-A|RPC10|S000001185|RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
YMR047C	0.877998	YDR026c	YMR047C|NUP116|S000004650|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p
YFR050C	0.868676	YDR026c	YFR050C|PRE4|S000001946|Beta 7 subunit of the 20S proteasome
YGR189C	0.867095	YDR026c	YGR189C|CRH1|S000003421|Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YGL111W	0.866865	YDR026c	YGL111W|NSA1|S000003079|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YGL252C	0.865563	YDR026c	YGL252C|RTG2|S000003221|Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
YOL161C	0.863422	YDR026c	YOL161C|PAU20|S000005521|Hypothetical protein
YPR091C	0.860046	YDR026c	YPR091C||S000006295|Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene
YGL149W	0.858492	YDR026c	YGL149W||S000003117|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
YML074C	0.857618	YDR026c	YML074C|FPR3|S000004539|Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YDR384C	0.850705	YDR026c	YDR384C|ATO3|S000002792|Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YGR020C	0.848477	YDR026c	YGR020C|VMA7|S000003252|Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YIL161W	0.84727	YDR026c	YIL161W||S000001423|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
YML122C	0.846989	YDR026c	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL177W	0.840042	YDR026c	YGL177W||S000003145|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR031C	0.839831	YDR026c	YHR031C|RRM3|S000001073|DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YNL272C	0.83315	YDR026c	YNL272C|SEC2|S000005216|Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport
YER092W	0.831673	YDR026c	YER092W|IES5|S000000894|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YLR229C	0.826597	YDR026c	YLR229C|CDC42|S000004219|Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YJL039C	0.824784	YDR026c	YJL039C|NUP192|S000003576|Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
YER023C-A	0.823775	YDR026c	YER023C-A||S000028622|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YKL068W-A	0.822602	YDR026c	YKL068W-A||S000028524|Putative protein of unknown function; identified by homology to Ashbya gossypii
YMR319C	0.821433	YDR026c	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YEL022W	0.817355	YDR026c	YEL022W|GEA2|S000000748|Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p
YJL025W	0.814764	YDR026c	YJL025W|RRN7|S000003562|Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein
YLR380W	0.813193	YDR026c	YLR380W|CSR1|S000004372|Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YEL063C	0.808189	YDR026c	YEL063C|CAN1|S000000789|Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
YMR071C	0.807448	YDR026c	YMR071C|TVP18|S000004675|Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
YLR195C	0.803354	YDR026c	YLR195C|NMT1|S000004185|N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
YDR008C	0.803295	YDR026c	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL020W	0.801344	YDR026c	YOL020W|TAT2|S000005380|High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YNL184C	0.801034	YDR026c	YNL184C||S000005128|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL155C	0.800199	YDR026c	YOL155C|HPF1|S000005515|Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YJL006C	0.799199	YDR026c	YJL006C|CTK2|S000003543|Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins
YEL032W	0.798807	YDR026c	YEL032W|MCM3|S000000758|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YPL011C	0.790723	YDR026c	YPL011C|TAF3|S000005932|TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
YBL046W	0.7878	YDR026c	YBL046W|PSY4|S000000142|Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus
YDR365C	0.782647	YDR026c	YDR365C|ESF1|S000002773|Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YKR023W	0.781883	YDR026c	YKR023W||S000001731|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR089W	0.780738	YDR026c	YDR089W||S000002496|Protein of unknown function; deletion confers resistance to Nickel
YOR009W	0.776099	YDR026c	YOR009W|TIR4|S000005535|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
YIR012W	0.77572	YDR026c	YIR012W|SQT1|S000001451|Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YDL205C	0.772022	YDR026c	YDL205C|HEM3|S000002364|Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YHR201C	0.768666	YDR026c	YHR201C|PPX1|S000001244|Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YNR038W	0.764629	YDR026c	YNR038W|DBP6|S000005321|Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YLR168C	0.763596	YDR026c	YLR168C|AIM30|S000004158|Putative protein of unknown function that may be involved in intramitochondrial sorting; similar to Ups1p and to human PRELI; GFP-tagged protein localizes to mitochondria; required for wild-type respiratory growth
YER178W	0.762529	YDR026c	YER178W|PDA1|S000000980|E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
YHR005C-A	0.76047	YDR026c	YHR005C-A|MRS11|S000003530|Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YOR356W	0.758928	YDR026c	YOR356W||S000005883|Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases
YER068W	0.758833	YDR026c	YER068W|MOT2|S000000870|Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
YBR068C	0.751309	YDR026c	YBR068C|BAP2|S000000272|High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains
YPL084W	0.747895	YDR026c	YPL084W|BRO1|S000006005|Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
YIL145C	0.745392	YDR026c	YIL145C|PAN6|S000001407|Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YKR039W	0.744257	YDR026c	YKR039W|GAP1|S000001747|General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YER062C	0.743858	YDR026c	YER062C|HOR2|S000000864|One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YBR007C	0.736842	YDR026c	YBR007C|DSF2|S000000211|Deletion suppressor of mpt5 mutation
YPL112C	0.733788	YDR026c	YPL112C|PEX25|S000006033|Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YGR040W	0.731484	YDR026c	YGR040W|KSS1|S000003272|Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YJL026C-A	0.720787	YDR026c	YJL026C-A||S000028660|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2
YLR222C	0.7135	YDR026c	YLR222C|UTP13|S000004212|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNR052C	0.712181	YDR026c	YNR052C|POP2|S000005335|RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
YLR230W	0.710863	YDR026c	YLR230W||S000004220|Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
YFR037C	0.709183	YDR026c	YFR037C|RSC8|S000001933|Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YKL045W	0.708182	YDR026c	YKL045W|PRI2|S000001528|Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YOR247W	0.70587	YDR026c	YOR247W|SRL1|S000005773|Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YBR202W	0.705702	YDR026c	YBR202W|MCM7|S000000406|Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YPR080W	0.699675	YDR026c	YPR080W|TEF1|S000006284|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YGR017W	0.698793	YDR026c	YGR017W||S000003249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YMR128W	0.698335	YDR026c	YMR128W|ECM16|S000004735|Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
YOR355W	0.697801	YDR026c	YOR355W|GDS1|S000005882|Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL212C	0.69617	YDR026c	YPL212C|PUS1|S000006133|tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
YHR064C	0.691661	YDR026c	YHR064C|SSZ1|S000001106|Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YJR110W	0.691292	YDR026c	YJR110W|YMR1|S000003871|Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family
YOR077W	0.688834	YDR026c	YOR077W|RTS2|S000005603|Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
YDL155W	0.684879	YDR026c	YDL155W|CLB3|S000002314|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YLR099C	0.683736	YDR026c	YLR099C|ICT1|S000004089|Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress
YPL218W	0.681645	YDR026c	YPL218W|SAR1|S000006139|GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
YNL281W	0.68031	YDR026c	YNL281W|HCH1|S000005225|Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus
YBR253W	0.678451	YDR026c	YBR253W|SRB6|S000000457|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YCR094W	0.676774	YDR026c	YCR094W|CDC50|S000000690|Endosomal protein that regulates cell polarity, controls polarized growth; similar to Ynr048wp and Lem3p
YGR139W	0.676493	YDR026c	YGR139W||S000003371|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL068W	0.672506	YDR026c	YGL068W|MNP1|S000003036|Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
YGL058W	0.670529	YDR026c	YGL058W|RAD6|S000003026|Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
YDR284C	0.661705	YDR026c	YDR284C|DPP1|S000002692|Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YML030W	0.65799	YDR026c	YML030W|AIM31|S000004492|Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth rate in minimal glycerol media
YJL162C	0.657504	YDR026c	YJL162C|JJJ2|S000003698|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YNL024C	0.653991	YDR026c	YNL024C||S000004969|Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YNR012W	0.646256	YDR026c	YNR012W|URK1|S000005295|Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
YDR086C	0.646247	YDR026c	YDR086C|SSS1|S000002493|Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YDR155C	0.640528	YDR026c	YDR155C|CPR1|S000002562|Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YFL039C	0.637079	YDR026c	YFL039C|ACT1|S000001855|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YLR283W	0.636469	YDR026c	YLR283W||S000004273|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
YKR072C	0.635881	YDR026c	YKR072C|SIS2|S000001780|Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression
YCR032W	0.634165	YDR026c	YCR032W|BPH1|S000000628|PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
YOR163W	0.632725	YDR026c	YOR163W|DDP1|S000005689|Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YKL053W	0.632088	YDR026c	YKL053W||S000001536|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
YGL224C	0.631521	YDR026c	YGL224C|SDT1|S000003192|Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
YDR035W	0.631421	YDR026c	YDR035W|ARO3|S000002442|3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
YFL038C	0.627497	YDR026c	YFL038C|YPT1|S000001856|Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YBR061C	0.627225	YDR026c	YBR061C|TRM7|S000000265|2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
YCR047C	0.622788	YDR026c	YCR047C|BUD23|S000000643|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YBR106W	0.622336	YDR026c	YBR106W|PHO88|S000000310|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YLR277C	0.621277	YDR026c	YLR277C|YSH1|S000004267|Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs
YOR189W	0.620144	YDR026c	YOR189W|IES4|S000005715|Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
YBL011W	0.613441	YDR026c	YBL011W|SCT1|S000000107|Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
YBR283C	0.611799	YDR026c	YBR283C|SSH1|S000000487|Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YNL289W	0.598463	YDR026c	YNL289W|PCL1|S000005233|Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YOR076C	0.597311	YDR026c	YOR076C|SKI7|S000005602|Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs
YDR154C	0.595573	YDR026c	YDR154C||S000002561|Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YOR330C	0.593588	YDR026c	YOR330C|MIP1|S000005857|Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome.
YGL258W	0.5907	YDR026c	YGL258W|VEL1|S000003227|Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YDR238C	0.590615	YDR026c	YDR238C|SEC26|S000002646|Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YEL021W	0.588994	YDR026c	YEL021W|URA3|S000000747|Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound
YPL238C	0.587184	YDR026c	YPL238C||S000006159|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
YCL007C	0.584552	YDR026c	YCL007C||S000000513|Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
YCR024C-B	0.58447	YDR026c	YCR024C-B||S000028818|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YML064C	0.581915	YDR026c	YML064C|TEM1|S000004529|GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
YDR158W	0.581239	YDR026c	YDR158W|HOM2|S000002565|Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YPR036W	0.577852	YDR026c	YPR036W|VMA13|S000006240|Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
YHL030W	0.57377	YDR026c	YHL030W|ECM29|S000001022|Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
YLR446W	0.573768	YDR026c	YLR446W||S000004438|Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
YDR429C	0.569972	YDR026c	YDR429C|TIF35|S000002837|Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YBR232C	0.568064	YDR026c	YBR232C||S000000436|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL143W	0.567438	YDR026c	YPL143W|RPL33A|S000006064|N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YPR033C	0.566354	YDR026c	YPR033C|HTS1|S000006237|Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YGL238W	0.563243	YDR026c	YGL238W|CSE1|S000003207|Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YOL115W	0.562283	YDR026c	YOL115W|PAP2|S000005475|Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase
YBR233W	0.558022	YDR026c	YBR233W|PBP2|S000000437|RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
YOL006C	0.557175	YDR026c	YOL006C|TOP1|S000005366|Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YNL206C	0.557034	YDR026c	YNL206C|RTT106|S000005150|Protein with a role in regulation of Ty1 transposition
YGL181W	0.556051	YDR026c	YGL181W|GTS1|S000003149|Protein that localizes to the nucleus and is involved in transcription regulation; also localizes to actin patches and plays a role in endocytosis; N-terminus contains an ARF-GAP domain and C-terminus contains a Gln-rich domain
YER112W	0.552135	YDR026c	YER112W|LSM4|S000000914|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR027C	0.551292	YDR026c	YLR027C|AAT2|S000004017|Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YJL218W	0.551045	YDR026c	YJL218W||S000003754|Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YCR047W-A	0.547697	YDR026c	YCR047W-A||S000028608|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YNL056W	0.546888	YDR026c	YNL056W|OCA2|S000005001|Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
YBR044C	0.544143	YDR026c	YBR044C|TCM62|S000000248|Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YNL234W	0.537566	YDR026c	YNL234W||S000005178|Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YOR319W	0.537062	YDR026c	YOR319W|HSH49|S000005846|U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YAL040C	0.536905	YDR026c	YAL040C|CLN3|S000000038|G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YER036C	0.53664	YDR026c	YER036C|ARB1|S000000838|ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YOR311C	0.533988	YDR026c	YOR311C|DGK1|S000005838|Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
YPL267W	0.532052	YDR026c	YPL267W|ACM1|S000006188|Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
YMR125W	0.530852	YDR026c	YMR125W|STO1|S000004732|Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
YLR225C	0.527739	YDR026c	YLR225C||S000004215|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
YAR008W	0.527377	YDR026c	YAR008W|SEN34|S000000066|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YBL034C	0.527155	YDR026c	YBL034C|STU1|S000000130|Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
YBL108W	0.526439	YDR026c	YBL108W||S000000204|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR099W	0.518684	YDR026c	YKR099W|BAS1|S000001807|Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YOR033C	0.517334	YDR026c	YOR033C|EXO1|S000005559|5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
YFR052W	0.515722	YDR026c	YFR052W|RPN12|S000001948|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
YPL237W	0.51499	YDR026c	YPL237W|SUI3|S000006158|Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
YDR535C	0.510933	YDR026c	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YOR269W	0.509032	YDR026c	YOR269W|PAC1|S000005795|Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
YOR326W	0.50461	YDR026c	YOR326W|MYO2|S000005853|One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
YML022W	0.504269	YDR026c	YML022W|APT1|S000004484|Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YDL078C	0.503306	YDR026c	YDL078C|MDH3|S000002236|Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YDL179W	0.503006	YDR026c	YDL179W|PCL9|S000002338|Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
YDR349C	0.50296	YDR026c	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YIR007W	0.501714	YDR026c	YIR007W||S000001446|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YNL135C	0.48774	YDR026c	YNL135C|FPR1|S000005079|Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
YCL049C	0.487329	YDR026c	YCL049C||S000000554|Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YPR195C	0.486134	YDR026c	YPR195C||S000006399|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER050C	0.482507	YDR026c	YER050C|RSM18|S000000852|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
YER086W	0.482412	YDR026c	YER086W|ILV1|S000000888|Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YJL143W	0.481048	YDR026c	YJL143W|TIM17|S000003679|Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import
YLR298C	0.479487	YDR026c	YLR298C|YHC1|S000004289|Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YOR103C	0.474195	YDR026c	YOR103C|OST2|S000005629|Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YLR455W	0.473228	YDR026c	YLR455W||S000004447|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDL071C	0.472692	YDR026c	YDL071C||S000002229|Hypothetical protein
YDL175C	0.47166	YDR026c	YDL175C|AIR2|S000002334|RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p
YBR053C	0.463739	YDR026c	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YCL043C	0.462471	YDR026c	YCL043C|PDI1|S000000548|Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds
YOR181W	0.460088	YDR026c	YOR181W|LAS17|S000005707|Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
YBR211C	0.458867	YDR026c	YBR211C|AME1|S000000415|Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance
YDL240W	0.451675	YDR026c	YDL240W|LRG1|S000002399|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YBL029W	0.451652	YDR026c	YBL029W||S000000125|Non-essential protein of unknown function
YOL142W	0.449242	YDR026c	YOL142W|RRP40|S000005502|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YOR180C	0.447518	YDR026c	YOR180C|DCI1|S000005706|Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini
YGR134W	0.44167	YDR026c	YGR134W|CAF130|S000003366|Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YLR412C-A	0.441276	YDR026c	YLR412C-A||S000028572|Putative protein of unknown function
YOR104W	0.439215	YDR026c	YOR104W|PIN2|S000005630|Protein that induces appearance of [PIN+] prion when overproduced
YKR090W	0.432185	YDR026c	YKR090W|PXL1|S000001798|LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
YGL037C	0.431112	YDR026c	YGL037C|PNC1|S000003005|Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
YDL133W	0.429857	YDR026c	YDL133W||S000002291|Putative protein of unknown function
YMR266W	0.429551	YDR026c	YMR266W|RSN1|S000004879|Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YGR270C-A	0.428634	YDR026c	YGR270C-A||S000028641|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W
YPR052C	0.427289	YDR026c	YPR052C|NHP6A|S000006256|High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YGR180C	0.424042	YDR026c	YGR180C|RNR4|S000003412|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YNL126W	0.423644	YDR026c	YNL126W|SPC98|S000005070|Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YML007W	0.423512	YDR026c	YML007W|YAP1|S000004466|Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
YGR038W	0.423183	YDR026c	YGR038W|ORM1|S000003270|Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YJL150W	0.421401	YDR026c	YJL150W||S000003686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR056W	0.418416	YDR026c	YLR056W|ERG3|S000004046|C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YDR122W	0.416564	YDR026c	YDR122W|KIN1|S000002529|Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YER034W	0.409801	YDR026c	YER034W||S000000836|Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YGL036W	0.407987	YDR026c	YGL036W||S000003004|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
YJL044C	0.403135	YDR026c	YJL044C|GYP6|S000003580|GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
YLL014W	0.402423	YDR026c	YLL014W||S000003937|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene
YPL093W	0.400089	YDR026c	YPL093W|NOG1|S000006014|Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YLR266C	0.39826	YDR026c	YLR266C|PDR8|S000004256|Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YBR012C	0.397876	YDR026c	YBR012C||S000000216|Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YNL235C	0.396726	YDR026c	YNL235C||S000005179|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YDR054C	0.396314	YDR026c	YDR054C|CDC34|S000002461|Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation
YOL022C	0.392483	YDR026c	YOL022C|TSR4|S000005382|Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YIL117C	0.3914	YDR026c	YIL117C|PRM5|S000001379|Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
YLR025W	0.390562	YDR026c	YLR025W|SNF7|S000004015|One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YAL034W-A	0.388928	YDR026c	YAL034W-A|MTW1|S000000032|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
YKR073C	0.388046	YDR026c	YKR073C||S000001781|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL092W	0.381885	YDR026c	YDL092W|SRP14|S000002250|Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YNL189W	0.381135	YDR026c	YNL189W|SRP1|S000005133|Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YBR157C	0.379438	YDR026c	YBR157C|ICS2|S000000361|Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YPR101W	0.378486	YDR026c	YPR101W|SNT309|S000006305|Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p
YER174C	0.373182	YDR026c	YER174C|GRX4|S000000976|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage
YDL017W	0.37164	YDR026c	YDL017W|CDC7|S000002175|DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
YJR098C	0.371208	YDR026c	YJR098C||S000003859|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR157W	0.370432	YDR026c	YDR157W||S000002564|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL061W	0.368144	YDR026c	YNL061W|NOP2|S000005005|Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YLR357W	0.367951	YDR026c	YLR357W|RSC2|S000004349|Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YML111W	0.364254	YDR026c	YML111W|BUL2|S000004579|Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YER044C-A	0.363856	YDR026c	YER044C-A|MEI4|S000001954|Meiosis-specific protein involved in recombination; required for chromosome synapsis; required for production of viable spores
YDR051C	0.363843	YDR026c	YDR051C||S000002458|Protein of unknown function; interacts with Hsp82p in two-hybrid assay; deletion confers sensitivity to Nickel
YBL014C	0.362273	YDR026c	YBL014C|RRN6|S000000110|Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein
YFL008W	0.360812	YDR026c	YFL008W|SMC1|S000001886|Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YOR196C	0.352928	YDR026c	YOR196C|LIP5|S000005722|Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
YMR037C	0.352695	YDR026c	YMR037C|MSN2|S000004640|Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YKL166C	0.35216	YDR026c	YKL166C|TPK3|S000001649|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YDL126C	0.352078	YDR026c	YDL126C|CDC48|S000002284|ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
YPL055C	0.349733	YDR026c	YPL055C|LGE1|S000005976|Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
YJL184W	0.34784	YDR026c	YJL184W|GON7|S000003720|Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p
YOR318C	0.343189	YDR026c	YOR318C||S000005845|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
YLR112W	0.34192	YDR026c	YLR112W||S000004102|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR070W	0.337381	YDR026c	YNR070W||S000005353|Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR191W	0.337112	YDR026c	YLR191W|PEX13|S000004181|Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YIL094C	0.336196	YDR026c	YIL094C|LYS12|S000001356|Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YOR109W	0.336189	YDR026c	YOR109W|INP53|S000005635|Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
YNL268W	0.335095	YDR026c	YNL268W|LYP1|S000005212|Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
YPR168W	0.329199	YDR026c	YPR168W|NUT2|S000006372|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription
YNL186W	0.326915	YDR026c	YNL186W|UBP10|S000005130|Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
YKL144C	0.325935	YDR026c	YKL144C|RPC25|S000001627|RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
YNL029C	0.321872	YDR026c	YNL029C|KTR5|S000004974|Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YMR149W	0.318425	YDR026c	YMR149W|SWP1|S000004757|Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
YDR491C	0.316997	YDR026c	YDR491C||S000002899|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL117W	0.316699	YDR026c	YJL117W|PHO86|S000003653|Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
YPL121C	0.314379	YDR026c	YPL121C|MEI5|S000006042|Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
YGR146C-A	0.312711	YDR026c	YGR146C-A||S000028638|Putative protein of unknown function
YNL027W	0.312199	YDR026c	YNL027W|CRZ1|S000004972|Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
YOR197W	0.308641	YDR026c	YOR197W|MCA1|S000005723|Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment
YOR321W	0.308015	YDR026c	YOR321W|PMT3|S000005848|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals
YDL125C	0.307127	YDR026c	YDL125C|HNT1|S000002283|Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YNL028W	0.306345	YDR026c	YNL028W||S000004973|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR012W	0.306052	YDR026c	YGR012W||S000003244|Putative cysteine synthase, localized to the mitochondrial outer membrane
YHR032W	0.305194	YDR026c	YHR032W||S000001074|Putative protein of unknown function; putative substrate of the cAMP-dependent protein kinase (PKA)
YKL143W	0.303834	YDR026c	YKL143W|LTV1|S000001626|Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YGR231C	0.301273	YDR026c	YGR231C|PHB2|S000003463|Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YOL125W	0.30022	YDR026c	YOL125W|TRM13|S000005485|2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases
YDR363W-A	0.29829	YDR026c	YDR363W-A|SEM1|S000007235|Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
YIL123W	0.294954	YDR026c	YIL123W|SIM1|S000001385|Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YKL191W	0.294619	YDR026c	YKL191W|DPH2|S000001674|Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
YOR354C	0.291919	YDR026c	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR181W	0.290646	YDR026c	YGR181W|TIM13|S000003413|Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YJL001W	0.290422	YDR026c	YJL001W|PRE3|S000003538|Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
YDR261C	0.28675	YDR026c	YDR261C|EXG2|S000002669|Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YPR053C	0.285511	YDR026c	YPR053C||S000006257|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
YCR095W-A	0.285239	YDR026c	YCR095W-A||S000029724|Putative protein of unknown function
YDR241W	0.283474	YDR026c	YDR241W|BUD26|S000002649|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YBR268W	0.282419	YDR026c	YBR268W|MRPL37|S000000472|Mitochondrial ribosomal protein of the large subunit
YLR170C	0.281131	YDR026c	YLR170C|APS1|S000004160|Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
YML041C	0.278737	YDR026c	YML041C|VPS71|S000004505|Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YLR082C	0.276723	YDR026c	YLR082C|SRL2|S000004072|Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
YHR098C	0.27536	YDR026c	YHR098C|SFB3|S000001140|Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate
YOL017W	0.271416	YDR026c	YOL017W|ESC8|S000005377|Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex
YER105C	0.26376	YDR026c	YER105C|NUP157|S000000907|Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p
YGR291C	0.26233	YDR026c	YGR291C||S000003523|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR368W	0.262232	YDR026c	YOR368W|RAD17|S000005895|Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
YGL026C	0.256892	YDR026c	YGL026C|TRP5|S000002994|Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis
YIL072W	0.255926	YDR026c	YIL072W|HOP1|S000001334|Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation
YPR122W	0.253316	YDR026c	YPR122W|AXL1|S000006326|Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
YPR149W	0.25185	YDR026c	YPR149W|NCE102|S000006353|Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YDL157C	0.251205	YDR026c	YDL157C||S000002316|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR226W	0.24747	YDR026c	YLR226W|BUR2|S000004216|Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
YIL029C	0.246387	YDR026c	YIL029C||S000001291|Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YER066C-A	0.244068	YDR026c	YER066C-A||S000002959|Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
YNL040W	0.243849	YDR026c	YNL040W||S000004985|Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene
YMR044W	0.242937	YDR026c	YMR044W|IOC4|S000004647|Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif
YBR081C	0.240794	YDR026c	YBR081C|SPT7|S000000285|Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YHR142W	0.238108	YDR026c	YHR142W|CHS7|S000001184|Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YOR119C	0.237663	YDR026c	YOR119C|RIO1|S000005645|Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YMR019W	0.236831	YDR026c	YMR019W|STB4|S000004621|Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins
YLR313C	0.235194	YDR026c	YLR313C|SPH1|S000004305|Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YKL058W	0.232488	YDR026c	YKL058W|TOA2|S000001541|TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA
YBR229C	0.231931	YDR026c	YBR229C|ROT2|S000000433|Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
YKR028W	0.229622	YDR026c	YKR028W|SAP190|S000001736|Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p
YGR163W	0.229161	YDR026c	YGR163W|GTR2|S000003395|Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
YNL313C	0.227384	YDR026c	YNL313C||S000005257|Putative protein of unknown function; identified as interacting with Kar2p, Grs1p, and Tub3p in high-throughput TAP-tagging experiments; YNL313C is an essential gene
YER019W	0.226966	YDR026c	YER019W|ISC1|S000000821|Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
YNR014W	0.226812	YDR026c	YNR014W||S000005297|Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YML031C-A	0.224011	YDR026c	YML031C-A||S000028809|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS
YAL056C-A	0.223937	YDR026c	YAL056C-A||S000002139|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR034W	0.222931	YDR026c	YPR034W|ARP7|S000006238|Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YPL016W	0.2229	YDR026c	YPL016W|SWI1|S000005937|Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can become prion [SWI+]
YGL098W	0.222169	YDR026c	YGL098W|USE1|S000003066|Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
YGR097W	0.222065	YDR026c	YGR097W|ASK10|S000003329|Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YJR060W	0.217974	YDR026c	YJR060W|CBF1|S000003821|Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA
YDR007W	0.2141	YDR026c	YDR007W|TRP1|S000002414|Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YER149C	0.213216	YDR026c	YER149C|PEA2|S000000951|Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
YDR477W	0.212084	YDR026c	YDR477W|SNF1|S000002885|AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YER002W	0.204245	YDR026c	YER002W|NOP16|S000000804|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YKL135C	0.197428	YDR026c	YKL135C|APL2|S000001618|Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting
YPR146C	0.196909	YDR026c	YPR146C||S000006350|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR281C	0.194235	YDR026c	YBR281C|DUG2|S000000485|Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YKR080W	0.1894	YDR026c	YKR080W|MTD1|S000001788|NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YNL062C	0.188963	YDR026c	YNL062C|GCD10|S000005006|Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YKL040C	0.187731	YDR026c	YKL040C|NFU1|S000001523|Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
YKL042W	0.187641	YDR026c	YKL042W|SPC42|S000001525|Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YGL234W	0.185964	YDR026c	YGL234W|ADE5,7|S000003203|Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YPR194C	0.184651	YDR026c	YPR194C|OPT2|S000006398|Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans
YML031W	0.183061	YDR026c	YML031W|NDC1|S000004493|Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
YFR038W	0.181125	YDR026c	YFR038W|IRC5|S000001934|Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci
YLR275W	0.178626	YDR026c	YLR275W|SMD2|S000004265|Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YNL279W	0.178306	YDR026c	YNL279W|PRM1|S000005223|Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
YNR032W	0.176566	YDR026c	YNR032W|PPG1|S000005315|Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
YHR179W	0.176279	YDR026c	YHR179W|OYE2|S000001222|Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YDR492W	0.174292	YDR026c	YDR492W|IZH1|S000002900|Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YNL263C	0.173967	YDR026c	YNL263C|YIF1|S000005207|Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles
YOL145C	0.172323	YDR026c	YOL145C|CTR9|S000005505|Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats
YPL204W	0.171924	YDR026c	YPL204W|HRR25|S000006125|Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YMR135W-A	0.171156	YDR026c	YMR135W-A||S000004743|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR099W	0.16844	YDR026c	YOR099W|KTR1|S000005625|Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YER027C	0.165616	YDR026c	YER027C|GAL83|S000000829|One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
YOR162C	0.164716	YDR026c	YOR162C|YRR1|S000005688|Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes
YOR012W	0.163693	YDR026c	YOR012W||S000005538|Putative protein of unknown function
YPL120W	0.16326	YDR026c	YPL120W|VPS30|S000006041|Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1
YNL221C	0.161869	YDR026c	YNL221C|POP1|S000005165|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P
YNL064C	0.161264	YDR026c	YNL064C|YDJ1|S000005008|Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
YGL100W	0.161072	YDR026c	YGL100W|SEH1|S000003068|Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p
YDL161W	0.159116	YDR026c	YDL161W|ENT1|S000002320|Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus
YDL006W	0.158709	YDR026c	YDL006W|PTC1|S000002164|Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
YBR093C	0.151866	YDR026c	YBR093C|PHO5|S000000297|Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YOR179C	0.14405	YDR026c	YOR179C|SYC1|S000005705|Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
YGR178C	0.144009	YDR026c	YGR178C|PBP1|S000003410|Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YHR041C	0.143789	YDR026c	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YPR145W	0.143746	YDR026c	YPR145W|ASN1|S000006349|Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YML113W	0.143383	YDR026c	YML113W|DAT1|S000004581|DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
YAL034C-B	0.138904	YDR026c	YAL034C-B||S000002137|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL125W	0.135484	YDR026c	YGL125W|MET13|S000003093|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YKL114C	0.134254	YDR026c	YKL114C|APN1|S000001597|Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
YER037W	0.133394	YDR026c	YER037W|PHM8|S000000839|Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p
YBL016W	0.132831	YDR026c	YBL016W|FUS3|S000000112|Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
YPR185W	0.127203	YDR026c	YPR185W|ATG13|S000006389|Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
YLR223C	0.125985	YDR026c	YLR223C|IFH1|S000004213|Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate
YKL059C	0.123805	YDR026c	YKL059C|MPE1|S000001542|Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YAR007C	0.122428	YDR026c	YAR007C|RFA1|S000000065|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YDL217C	0.119882	YDR026c	YDL217C|TIM22|S000002376|Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane
YEL057C	0.119837	YDR026c	YEL057C||S000000783|Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YBL004W	0.118402	YDR026c	YBL004W|UTP20|S000000100|Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YDL025C	0.114999	YDR026c	YDL025C||S000002183|Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YBR109C	0.112655	YDR026c	YBR109C|CMD1|S000000313|Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
YJL034W	0.112531	YDR026c	YJL034W|KAR2|S000003571|ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
YCR042C	0.112181	YDR026c	YCR042C|TAF2|S000000638|TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation
YNL218W	0.108885	YDR026c	YNL218W|MGS1|S000005162|Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
YLR044C	0.108212	YDR026c	YLR044C|PDC1|S000004034|Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
YNL008C	0.108049	YDR026c	YNL008C|ASI3|S000004953|Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YOR267C	0.107455	YDR026c	YOR267C|HRK1|S000005793|Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YGR196C	0.105788	YDR026c	YGR196C|FYV8|S000003428|Protein of unknown function, required for survival upon exposure to K1 killer toxin
YPL205C	0.1043	YDR026c	YPL205C||S000006126|Hypothetical protein; deletion of locus affects telomere length
YHL004W	0.103054	YDR026c	YHL004W|MRP4|S000000996|Mitochondrial ribosomal protein of the small subunit
YOR118W	0.097542	YDR026c	YOR118W|RTC5|S000005644|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
YMR238W	0.0962707	YDR026c	YMR238W|DFG5|S000004851|Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
YOR317W	0.0932668	YDR026c	YOR317W|FAA1|S000005844|Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YOR085W	0.0927319	YDR026c	YOR085W|OST3|S000005611|Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
YJR025C	0.091248	YDR026c	YJR025C|BNA1|S000003786|3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YNL233W	0.0868942	YDR026c	YNL233W|BNI4|S000005177|Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
YJL140W	0.0864654	YDR026c	YJL140W|RPB4|S000003676|RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions
YOR048C	0.0854375	YDR026c	YOR048C|RAT1|S000005574|Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YJL075C	0.0853897	YDR026c	YJL075C|APQ13|S000003611|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
YBR282W	0.0850993	YDR026c	YBR282W|MRPL27|S000000486|Mitochondrial ribosomal protein of the large subunit
YKR031C	0.0812334	YDR026c	YKR031C|SPO14|S000001739|Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
YGR270W	0.0809753	YDR026c	YGR270W|YTA7|S000003502|Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
YDR506C	0.0804504	YDR026c	YDR506C||S000002914|Possible membrane-localized protein
YLR039C	0.0795473	YDR026c	YLR039C|RIC1|S000004029|Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YAR014C	0.0777611	YDR026c	YAR014C|BUD14|S000000069|Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YMR136W	0.0765615	YDR026c	YMR136W|GAT2|S000004744|Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YNL312W	0.0757186	YDR026c	YNL312W|RFA2|S000005256|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YBL107C	0.0712326	YDR026c	YBL107C||S000000203|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene
YJL186W	0.0708721	YDR026c	YJL186W|MNN5|S000003722|Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YGR021W	0.0676226	YDR026c	YGR021W||S000003253|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR010C	0.0628742	YDR026c	YLR010C|TEN1|S000004000|Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YOL112W	0.0606657	YDR026c	YOL112W|MSB4|S000005472|GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
YMR265C	0.0603006	YDR026c	YMR265C||S000004878|Putative protein of unknown function
YOR095C	0.0580637	YDR026c	YOR095C|RKI1|S000005621|Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YEL031W	0.0567761	YDR026c	YEL031W|SPF1|S000000757|P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YGL228W	0.0555628	YDR026c	YGL228W|SHE10|S000003197|Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
YOR316C-A	0.0542705	YDR026c	YOR316C-A||S000028584|Putative protein of unknown function; identified by fungal homology and RT-PCR
YHL006C	0.0542145	YDR026c	YHL006C|SHU1|S000000998|Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
YLR255C	0.0524563	YDR026c	YLR255C||S000004245|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR325W	0.0514689	YDR026c	YOR325W||S000005852|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
YOR203W	0.0499359	YDR026c	YOR203W||S000005729|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation
YMR062C	0.0492697	YDR026c	YMR062C|ECM40|S000004666|Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YPR121W	0.0489215	YDR026c	YPR121W|THI22|S000006325|Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YKL101W	0.0476344	YDR026c	YKL101W|HSL1|S000001584|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YGR259C	0.0448444	YDR026c	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YLR408C	0.0445071	YDR026c	YLR408C||S000004400|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
YDL185C-A	0.0422752	YDR026c	YDL185C-A||S000007600|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species
YOL164W-A	0.0421995	YDR026c	YOL164W-A||S000028580|Putative protein of unknown function; identified by fungal homology and RT-PCR
YIL028W	0.0391074	YDR026c	YIL028W||S000001290|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR006C	0.0386539	YDR026c	YIR006C|PAN1|S000001445|Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
YLR024C	0.0385759	YDR026c	YLR024C|UBR2|S000004014|Cytoplasmic ubiquitin-protein ligase (E3)
YOR344C	0.0367489	YDR026c	YOR344C|TYE7|S000005871|Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YGR161W-C	0.0320891	YDR026c	YGR161W-C||S000029726|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YCR066W	0.0302989	YDR026c	YCR066W|RAD18|S000000662|Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif
YOR093C	0.0286003	YDR026c	YOR093C||S000005619|Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
YDL005C	0.0278315	YDR026c	YDL005C|MED2|S000002163|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YHR093W	0.0265914	YDR026c	YHR093W|AHT1|S000001135|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YOR324C	0.0250962	YDR026c	YOR324C|FRT1|S000005851|Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress
YNL041C	0.0235932	YDR026c	YNL041C|COG6|S000004986|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL205C	0.0219249	YDR026c	YNL205C||S000005149|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL049C	0.0206544	YDR026c	YNL049C|SFB2|S000004994|Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy
YNR031C	0.0203961	YDR026c	YNR031C|SSK2|S000005314|MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
YKL208W	0.0201772	YDR026c	YKL208W|CBT1|S000001691|Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
YJL065C	0.0131767	YDR026c	YJL065C|DLS1|S000003601|Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing
YPL173W	0.0128076	YDR026c	YPL173W|MRPL40|S000006094|Mitochondrial ribosomal protein of the large subunit
YER115C	0.0118445	YDR026c	YER115C|SPR6|S000000917|Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
YAR015W	0.0105869	YDR026c	YAR015W|ADE1|S000000070|N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YBR135W	0.0101295	YDR026c	YBR135W|CKS1|S000000339|Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
YHR014W	0.00993733	YDR026c	YHR014W|SPO13|S000001056|Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
YGR227W	0.00939451	YDR026c	YGR227W|DIE2|S000003459|Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
YDR420W	0.00667391	YDR026c	YDR420W|HKR1|S000002828|Serine/threonine rich cell surface protein; osmosensor; involved in the regulation of cell wall beta-1,3 glucan synthesis, bud site selection and hyperosmotic response; overexpression confers resistance to Hansenula mrakii killer toxin HM-1
YGL239C	0.00484661	YDR026c	YGL239C||S000003208|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1
YJR090C	0.00143772	YDR026c	YJR090C|GRR1|S000003850|F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
