YLR174W	23.0486	YLR278C	YLR174W|IDP2|S000004164|Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YJR095W	21.368	YLR278C	YJR095W|SFC1|S000003856|Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPL223C	21.0981	YLR278C	YPL223C|GRE1|S000006144|Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YJL045W	19.9995	YLR278C	YJL045W||S000003581|Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOR343C	19.7669	YLR278C	YOR343C||S000005870|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNR002C	18.4427	YLR278C	YNR002C|ATO2|S000005285|Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YLR377C	18.339	YLR278C	YLR377C|FBP1|S000004369|Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YER065C	15.3925	YLR278C	YER065C|ICL1|S000000867|Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YJL116C	15.3767	YLR278C	YJL116C|NCA3|S000003652|Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YFR053C	15.2758	YLR278C	YFR053C|HXK1|S000001949|Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YMR107W	15.2603	YLR278C	YMR107W|SPG4|S000004713|Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YKR097W	14.9351	YLR278C	YKR097W|PCK1|S000001805|Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YDR277C	14.3881	YLR278C	YDR277C|MTH1|S000002685|Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR017W	13.6702	YLR278C	YMR017W|SPO20|S000004619|Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YBR072W	13.5093	YLR278C	YBR072W|HSP26|S000000276|Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YAL062W	13.3288	YLR278C	YAL062W|GDH3|S000000058|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YIL057C	11.9538	YLR278C	YIL057C||S000001319|Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YHR096C	11.2541	YLR278C	YHR096C|HXT5|S000001138|Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YGR032W	10.8314	YLR278C	YGR032W|GSC2|S000003264|Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YJR048W	10.7036	YLR278C	YJR048W|CYC1|S000003809|Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR100C	10.4806	YLR278C	YOR100C|CRC1|S000005626|Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YPL171C	10.4782	YLR278C	YPL171C|OYE3|S000006092|Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YMR206W	10.3745	YLR278C	YMR206W||S000004819|Putative protein of unknown function; YMR206W is not an essential gene
YAR053W	9.73198	YLR278C	YAR053W||S000000085|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR139C	9.61469	YLR278C	YHR139C|SPS100|S000001181|Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YFL030W	9.59689	YLR278C	YFL030W|AGX1|S000001864|Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YML042W	9.25157	YLR278C	YML042W|CAT2|S000004506|Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YOR348C	9.25147	YLR278C	YOR348C|PUT4|S000005875|Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YBL015W	9.08725	YLR278C	YBL015W|ACH1|S000000111|Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YPL222W	9.0169	YLR278C	YPL222W|FMP40|S000006143|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL109W	8.96025	YLR278C	YKL109W|HAP4|S000001592|Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YGR067C	8.40358	YLR278C	YGR067C||S000003299|Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YGR110W	8.36938	YLR278C	YGR110W||S000003342|Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YBR116C	8.26227	YLR278C	YBR116C||S000000320|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YLL041C	8.17478	YLR278C	YLL041C|SDH2|S000003964|Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJL161W	7.51667	YLR278C	YJL161W|FMP33|S000003697|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR211W	7.30384	YLR278C	YHR211W|FLO5|S000001254|Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YAR060C	7.21865	YLR278C	YAR060C||S000000086|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR007C	7.08675	YLR278C	YCR007C||S000000600|Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YBL064C	6.98882	YLR278C	YBL064C|PRX1|S000000160|Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YPR023C	6.97639	YLR278C	YPR023C|EAF3|S000006227|Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YFL052W	6.96389	YLR278C	YFL052W||S000001842|Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YML089C	6.91421	YLR278C	YML089C||S000004554|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR036C	6.74399	YLR278C	YDR036C|EHD3|S000002443|3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YPR001W	6.74007	YLR278C	YPR001W|CIT3|S000006205|Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YEL008W	6.68629	YLR278C	YEL008W||S000000734|Hypothetical protein predicted to be involved in metabolism
YEL009C	6.59263	YLR278C	YEL009C|GCN4|S000000735|Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YPR151C	6.44263	YLR278C	YPR151C|SUE1|S000006355|Mitochondrial protein required for degradation of unstable forms of cytochrome c
YDL244W	6.19822	YLR278C	YDL244W|THI13|S000002403|Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YLR004C	6.06307	YLR278C	YLR004C|THI73|S000003994|Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YDR536W	5.91935	YLR278C	YDR536W|STL1|S000002944|Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YCR005C	5.87767	YLR278C	YCR005C|CIT2|S000000598|Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YPR030W	5.87152	YLR278C	YPR030W|CSR2|S000006234|Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YKR009C	5.76406	YLR278C	YKR009C|FOX2|S000001717|Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YGL258W-A	5.61073	YLR278C	YGL258W-A||S000007607|Putative protein of unknown function
YDR070C	5.57388	YLR278C	YDR070C|FMP16|S000002477|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR087C	5.54098	YLR278C	YGR087C|PDC6|S000003319|Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YMR244W	5.51122	YLR278C	YMR244W||S000004858|Putative protein of unknown function
YHL024W	5.49399	YLR278C	YHL024W|RIM4|S000001016|Putative RNA-binding protein required for the expression of early and middle sporulation genes
YPL201C	5.45977	YLR278C	YPL201C|YIG1|S000006122|Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YOL084W	5.37939	YLR278C	YOL084W|PHM7|S000005444|Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YLR149C	5.34012	YLR278C	YLR149C||S000004139|Putative protein of unknown function; YLR149C is not an essential gene
YOR139C	5.32128	YLR278C	YOR139C||S000005665|Hypothetical protein
YGL045W	5.2718	YLR278C	YGL045W|RIM8|S000003013|Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YKL148C	5.26816	YLR278C	YKL148C|SDH1|S000001631|Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YPL250C	5.25473	YLR278C	YPL250C|ICY2|S000006171|Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YPL186C	5.17571	YLR278C	YPL186C|UIP4|S000006107|Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YDL214C	5.141	YLR278C	YDL214C|PRR2|S000002373|Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YOR140W	5.12721	YLR278C	YOR140W|SFL1|S000005666|Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YLR296W	5.10153	YLR278C	YLR296W||S000004287|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER158C	5.06525	YLR278C	YER158C||S000000960|Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YOR049C	4.89776	YLR278C	YOR049C|RSB1|S000005575|Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YHR212C	4.87203	YLR278C	YHR212C||S000001255|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL017C	4.87054	YLR278C	YPL017C|IRC15|S000005938|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YOR120W	4.80045	YLR278C	YOR120W|GCY1|S000005646|Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YPR013C	4.75316	YLR278C	YPR013C||S000006217|Putative zinc finger protein; YPR013C is not an essential gene
YGR045C	4.75279	YLR278C	YGR045C||S000003277|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL163C	4.74389	YLR278C	YGL163C|RAD54|S000003131|DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YOL060C	4.70062	YLR278C	YOL060C|MAM3|S000005421|Protein required for normal mitochondrial morphology, has similarity to hemolysins
YDR216W	4.67525	YLR278C	YDR216W|ADR1|S000002624|Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YBR203W	4.65153	YLR278C	YBR203W|COS111|S000000407|Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR006C	4.64914	YLR278C	YPR006C|ICL2|S000006210|2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YPL185W	4.61631	YLR278C	YPL185W||S000006106|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YLR366W	4.60849	YLR278C	YLR366W||S000004358|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YKR102W	4.53081	YLR278C	YKR102W|FLO10|S000001810|Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YLR122C	4.49659	YLR278C	YLR122C||S000004112|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YPL024W	4.44758	YLR278C	YPL024W|RMI1|S000005945|Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YHR212W-A	4.44599	YLR278C	YHR212W-A||S000028650|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL181W	4.35509	YLR278C	YPL181W|CTI6|S000006102|Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YDR406W	4.34788	YLR278C	YDR406W|PDR15|S000002814|Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YML090W	4.33724	YLR278C	YML090W||S000004555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YAL039C	4.33064	YLR278C	YAL039C|CYC3|S000000037|Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YGR144W	4.32499	YLR278C	YGR144W|THI4|S000003376|Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YIR039C	4.30992	YLR278C	YIR039C|YPS6|S000001478|Putative GPI-anchored aspartic protease
YDL215C	4.29037	YLR278C	YDL215C|GDH2|S000002374|NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YDR343C	4.22862	YLR278C	YDR343C|HXT6|S000002751|High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR295C	4.21322	YLR278C	YLR295C|ATP14|S000004286|Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNL055C	4.1862	YLR278C	YNL055C|POR1|S000005000|Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YER098W	4.18443	YLR278C	YER098W|UBP9|S000000900|Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YPR196W	4.15385	YLR278C	YPR196W||S000006400|Putative maltose activator
YAR069C	4.11056	YLR278C	YAR069C||S000000092|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL182C	4.07418	YLR278C	YPL182C||S000006103|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YGR028W	4.06452	YLR278C	YGR028W|MSP1|S000003260|Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
YNR034W-A	4.05637	YLR278C	YNR034W-A||S000007525|Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YEL012W	3.98159	YLR278C	YEL012W|UBC8|S000000738|Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YPL015C	3.97992	YLR278C	YPL015C|HST2|S000005936|Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YLL053C	3.96041	YLR278C	YLL053C||S000003976|Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YAR070C	3.94147	YLR278C	YAR070C||S000000093|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML081C-A	3.93916	YLR278C	YML081C-A|ATP18|S000007247|Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YDL210W	3.92304	YLR278C	YDL210W|UGA4|S000002369|Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YEL070W	3.85556	YLR278C	YEL070W|DSF1|S000000796|Deletion suppressor of mpt5 mutation
YDR171W	3.84667	YLR278C	YDR171W|HSP42|S000002578|Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YPL026C	3.83368	YLR278C	YPL026C|SKS1|S000005947|Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YER066W	3.81161	YLR278C	YER066W||S000000868|Putative protein of unknown function; YER066W is not an essential gene
YAL018C	3.80247	YLR278C	YAL018C||S000000016|Putative protein of unknown function
YEL049W	3.78739	YLR278C	YEL049W|PAU2|S000000775|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGR243W	3.78145	YLR278C	YGR243W|FMP43|S000003475|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR123C	3.76277	YLR278C	YLR123C||S000004113|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YAL054C	3.75668	YLR278C	YAL054C|ACS1|S000000050|Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YAL063C	3.74848	YLR278C	YAL063C|FLO9|S000000059|Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YKR040C	3.66852	YLR278C	YKR040C||S000001748|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YGL053W	3.64622	YLR278C	YGL053W|PRM8|S000003021|Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YDL246C	3.64595	YLR278C	YDL246C|SOR2|S000002405|Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YGR288W	3.63039	YLR278C	YGR288W|MAL13|S000003520|MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YOR393W	3.62501	YLR278C	YOR393W|ERR1|S000005920|Protein of unknown function, has similarity to enolases
YLR334C	3.59698	YLR278C	YLR334C||S000004326|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YDR441C	3.59056	YLR278C	YDR441C|APT2|S000002849|Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YLR356W	3.59029	YLR278C	YLR356W||S000004348|Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YGL205W	3.55669	YLR278C	YGL205W|POX1|S000003173|Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YFL024C	3.55355	YLR278C	YFL024C|EPL1|S000001870|Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YNL180C	3.53464	YLR278C	YNL180C|RHO5|S000005124|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YLL052C	3.53332	YLR278C	YLL052C|AQY2|S000003975|Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YDR043C	3.52086	YLR278C	YDR043C|NRG1|S000002450|Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YDL138W	3.44463	YLR278C	YDL138W|RGT2|S000002297|Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YPL058C	3.42791	YLR278C	YPL058C|PDR12|S000005979|Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YJL127C-B	3.42468	YLR278C	YJL127C-B||S000028522|Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YLL019C	3.4125	YLR278C	YLL019C|KNS1|S000003942|Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YPL135W	3.40395	YLR278C	YPL135W|ISU1|S000006056|Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YDL245C	3.3919	YLR278C	YDL245C|HXT15|S000002404|Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YPL200W	3.36917	YLR278C	YPL200W|CSM4|S000006121|Protein required for accurate chromosome segregation during meiosis
YNL277W-A	3.35683	YLR278C	YNL277W-A||S000028852|Putative protein of unknown function
YHR080C	3.35447	YLR278C	YHR080C||S000001122|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML091C	3.35043	YLR278C	YML091C|RPM2|S000004556|Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YGR088W	3.34811	YLR278C	YGR088W|CTT1|S000003320|Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YPL222C-A	3.31979	YLR278C	YPL222C-A||S000028722|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJR151C	3.30867	YLR278C	YJR151C|DAN4|S000003912|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOR138C	3.30848	YLR278C	YOR138C|RUP1|S000005664|Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YDL194W	3.29992	YLR278C	YDL194W|SNF3|S000002353|Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YNL179C	3.28586	YLR278C	YNL179C||S000005123|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YJL112W	3.28488	YLR278C	YJL112W|MDV1|S000003648|Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YOR381W	3.27356	YLR278C	YOR381W|FRE3|S000005908|Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YDL130W-A	3.24875	YLR278C	YDL130W-A|STF1|S000007232|Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YOR388C	3.24437	YLR278C	YOR388C|FDH1|S000005915|NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YCL001W-B	3.21345	YLR278C	YCL001W-B||S000007596|Putative protein of unknown function; identified by homology
YPR015C	3.20569	YLR278C	YPR015C||S000006219|Putative protein of unknown function
YOR378W	3.17947	YLR278C	YOR378W||S000005905|Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YIR029W	3.1755	YLR278C	YIR029W|DAL2|S000001468|Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YER097W	3.15892	YLR278C	YER097W||S000000899|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR052C-A	3.15843	YLR278C	YFR052C-A||S000028768|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR530C	3.11694	YLR278C	YDR530C|APA2|S000002938|Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YHR210C	3.10227	YLR278C	YHR210C||S000001253|Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YLR365W	3.06634	YLR278C	YLR365W||S000004357|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YFL054C	3.01992	YLR278C	YFL054C||S000001840|Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YOR223W	3.00869	YLR278C	YOR223W||S000005749|Putative protein of unknown function
YBR179C	2.99882	YLR278C	YBR179C|FZO1|S000000383|Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YMR250W	2.9814	YLR278C	YMR250W|GAD1|S000004862|Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YAR068W	2.9697	YLR278C	YAR068W||S000000091|Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YJR159W	2.95902	YLR278C	YJR159W|SOR1|S000003920|Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YIR027C	2.94465	YLR278C	YIR027C|DAL1|S000001466|Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YFL051C	2.94209	YLR278C	YFL051C||S000001843|Putative protein of unknown function; YFL051C is not an essential gene
YMR081C	2.93893	YLR278C	YMR081C|ISF1|S000004686|Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YLR124W	2.9083	YLR278C	YLR124W||S000004114|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR019C	2.90486	YLR278C	YBR019C|GAL10|S000000223|UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YGR174C	2.87773	YLR278C	YGR174C|CBP4|S000003406|Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p
YDR102C	2.86941	YLR278C	YDR102C||S000002509|Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YGL134W	2.85184	YLR278C	YGL134W|PCL10|S000003102|Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YDR030C	2.84219	YLR278C	YDR030C|RAD28|S000002437|Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
YMR182C	2.8015	YLR278C	YMR182C|RGM1|S000004794|Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YKL171W	2.78945	YLR278C	YKL171W||S000001654|Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YEL065W	2.78578	YLR278C	YEL065W|SIT1|S000000791|Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YNL274C	2.76737	YLR278C	YNL274C|GOR1|S000005218|Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER091C-A	2.74847	YLR278C	YER091C-A||S000007238|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR154W	2.7419	YLR278C	YJR154W||S000003915|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR312C	2.74035	YLR278C	YLR312C|QNQ1|S000004303|Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YPL271W	2.70223	YLR278C	YPL271W|ATP15|S000006192|Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOL157C	2.69452	YLR278C	YOL157C||S000005517|Putative protein of unknown function
YOL051W	2.68604	YLR278C	YOL051W|GAL11|S000005411|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YGR239C	2.67887	YLR278C	YGR239C|PEX21|S000003471|Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YPR024W	2.67406	YLR278C	YPR024W|YME1|S000006228|Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YLL018C-A	2.65861	YLR278C	YLL018C-A|COX19|S000007245|Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YJL166W	2.65178	YLR278C	YJL166W|QCR8|S000003702|Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YDR148C	2.64774	YLR278C	YDR148C|KGD2|S000002555|Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YMR181C	2.63835	YLR278C	YMR181C||S000004793|Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YMR018W	2.63555	YLR278C	YMR018W||S000004620|Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YEL007W	2.63069	YLR278C	YEL007W||S000000733|Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YDR287W	2.62952	YLR278C	YDR287W|INM2|S000002695|Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YER004W	2.62713	YLR278C	YER004W|FMP52|S000000806|Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR538W	2.62549	YLR278C	YDR538W|PAD1|S000002946|Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX
YDR058C	2.61947	YLR278C	YDR058C|TGL2|S000002465|Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear
YOL055C	2.56566	YLR278C	YOL055C|THI20|S000005416|Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YGR221C	2.55208	YLR278C	YGR221C|TOS2|S000003453|Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
YLR053C	2.52941	YLR278C	YLR053C||S000004043|Putative protein of unknown function
YHR095W	2.52907	YLR278C	YHR095W||S000001137|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR031W	2.52033	YLR278C	YDR031W|MIC14|S000002438|Mitochondrial intermembrane space cysteine motif protein of 14 kDa
YLR152C	2.50116	YLR278C	YLR152C||S000004142|Putative protein of unknown function; YLR152C is not an essential gene
YML083C	2.49835	YLR278C	YML083C||S000004548|Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YNL144C	2.48901	YLR278C	YNL144C||S000005088|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YOR371C	2.46767	YLR278C	YOR371C|GPB1|S000005898|Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p
YGR258C	2.46447	YLR278C	YGR258C|RAD2|S000003490|Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YOL085W-A	2.45387	YLR278C	YOL085W-A||S000028708|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YKR015C	2.4354	YLR278C	YKR015C||S000001723|Putative protein of unknown function
YFL055W	2.42418	YLR278C	YFL055W|AGP3|S000001839|Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YNL074C	2.41857	YLR278C	YNL074C|MLF3|S000005018|Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YNL018C	2.41575	YLR278C	YNL018C||S000004963|Putative protein of unknown function
YDR342C	2.4156	YLR278C	YDR342C|HXT7|S000002750|High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YBR180W	2.41445	YLR278C	YBR180W|DTR1|S000000384|Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YLR327C	2.38705	YLR278C	YLR327C|TMA10|S000004319|Protein of unknown function that associates with ribosomes
YOR391C	2.36874	YLR278C	YOR391C|HSP33|S000005918|Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YLR125W	2.36759	YLR278C	YLR125W||S000004115|Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YJL152W	2.35158	YLR278C	YJL152W||S000003688|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL079C	2.34913	YLR278C	YDL079C|MRK1|S000002237|Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YDR442W	2.34623	YLR278C	YDR442W||S000002850|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR152C	2.33124	YLR278C	YOR152C||S000005678|Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YHL041W	2.30578	YLR278C	YHL041W||S000001033|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YGL215W	2.29866	YLR278C	YGL215W|CLG1|S000003183|Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
YOL156W	2.28929	YLR278C	YOL156W|HXT11|S000005516|Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
YHR139C-A	2.2755	YLR278C	YHR139C-A||S000003533|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL242W	2.27042	YLR278C	YNL242W|ATG2|S000005186|Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria
YHR079C-A	2.24837	YLR278C	YHR079C-A|SAE3|S000001957|Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
YAR050W	2.23802	YLR278C	YAR050W|FLO1|S000000084|Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YER119C	2.23688	YLR278C	YER119C|AVT6|S000000921|Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YDL224C	2.22884	YLR278C	YDL224C|WHI4|S000002383|Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YDR022C	2.22865	YLR278C	YDR022C|CIS1|S000002429|Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YLR297W	2.19635	YLR278C	YLR297W||S000004288|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOL100W	2.19634	YLR278C	YOL100W|PKH2|S000005460|Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YOR389W	2.18533	YLR278C	YOR389W||S000005916|Putative protein of unknown function; expression regulated by copper levels
YJL089W	2.1849	YLR278C	YJL089W|SIP4|S000003625|C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YDR103W	2.18168	YLR278C	YDR103W|STE5|S000002510|Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YOR065W	2.18112	YLR278C	YOR065W|CYT1|S000005591|Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YGL180W	2.16722	YLR278C	YGL180W|ATG1|S000003148|Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YKL146W	2.14393	YLR278C	YKL146W|AVT3|S000001629|Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YMR135C	2.1423	YLR278C	YMR135C|GID8|S000004742|Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YDR032C	2.13141	YLR278C	YDR032C|PST2|S000002439|Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL053W	2.10763	YLR278C	YFL053W|DAK2|S000001841|Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YKL147C	2.09867	YLR278C	YKL147C||S000001630|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YBR033W	2.08927	YLR278C	YBR033W|EDS1|S000000237|Putative zinc cluster protein; YBR033W is not an essential gene
YDR119W-A	2.08821	YLR278C	YDR119W-A||S000113555|Putative protein of unknown function
YDL182W	2.08738	YLR278C	YDL182W|LYS20|S000002341|Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YPL230W	2.07126	YLR278C	YPL230W|USV1|S000006151|Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YGL081W	2.05552	YLR278C	YGL081W||S000003049|Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
YIR034C	2.05219	YLR278C	YIR034C|LYS1|S000001473|Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway
YGR046W	2.04208	YLR278C	YGR046W|TAM41|S000003278|Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud
YPR192W	2.0238	YLR278C	YPR192W|AQY1|S000006396|Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YAR023C	2.00355	YLR278C	YAR023C||S000000074|Putative integral membrane protein, member of DUP240 gene family
YIL037C	1.9916	YLR278C	YIL037C|PRM2|S000001299|Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YPR007C	1.98487	YLR278C	YPR007C|REC8|S000006211|Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YAL017W	1.97154	YLR278C	YAL017W|PSK1|S000000015|One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YLR279W	1.96344	YLR278C	YLR279W||S000004269|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL065W	1.95917	YLR278C	YCL065W||S000000570|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1
YLR307C-A	1.95587	YLR278C	YLR307C-A||S000028525|Putative protein of unknown function
YPL179W	1.95281	YLR278C	YPL179W|PPQ1|S000006100|Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
YLR324W	1.94408	YLR278C	YLR324W|PEX30|S000004316|Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YEL074W	1.9391	YLR278C	YEL074W||S000000800|Hypothetical protein
YJR146W	1.89379	YLR278C	YJR146W||S000003907|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YFL061W	1.88241	YLR278C	YFL061W|DDI2|S000001833|Protein whose expression is induced by DNA damage
YEL024W	1.87697	YLR278C	YEL024W|RIP1|S000000750|Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YER167W	1.87596	YLR278C	YER167W|BCK2|S000000969|Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YHR048W	1.87521	YLR278C	YHR048W|YHK8|S000001090|Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YGR256W	1.86625	YLR278C	YGR256W|GND2|S000003488|6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YKL151C	1.86049	YLR278C	YKL151C||S000001634|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YAR047C	1.85844	YLR278C	YAR047C||S000000083|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL044W	1.85311	YLR278C	YOL044W|PEX15|S000005404|Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
YBR290W	1.83019	YLR278C	YBR290W|BSD2|S000000494|Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
YLR431C	1.81021	YLR278C	YLR431C|ATG23|S000004423|Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YDR247W	1.8051	YLR278C	YDR247W|VHS1|S000002655|Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YJR115W	1.79929	YLR278C	YJR115W||S000003876|Putative protein of unknown function
YOR221C	1.79833	YLR278C	YOR221C|MCT1|S000005747|Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
YCR041W	1.79538	YLR278C	YCR041W||S000000637|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR146C	1.7945	YLR278C	YGR146C||S000003378|Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR020W	1.78199	YLR278C	YBR020W|GAL1|S000000224|Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
YGR044C	1.75487	YLR278C	YGR044C|RME1|S000003276|Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation
YMR148W	1.75281	YLR278C	YMR148W||S000004756|Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene
YMR090W	1.74886	YLR278C	YMR090W||S000004696|Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YBR056W-A	1.7353	YLR278C	YBR056W-A||S000028736|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YNL142W	1.73365	YLR278C	YNL142W|MEP2|S000005086|Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YNL014W	1.72116	YLR278C	YNL014W|HEF3|S000004959|Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YOR192C	1.72089	YLR278C	YOR192C|THI72|S000005718|Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YBR209W	1.71592	YLR278C	YBR209W||S000000413|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YLR111W	1.71332	YLR278C	YLR111W||S000004101|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR026C	1.70725	YLR278C	YFR026C||S000001922|Putative protein of unknown function
YKR098C	1.67651	YLR278C	YKR098C|UBP11|S000001806|Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
YKL031W	1.6717	YLR278C	YKL031W||S000001514|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YEL028W	1.66948	YLR278C	YEL028W||S000000754|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL028W	1.66613	YLR278C	YKL028W|TFA1|S000001511|TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YJL213W	1.6555	YLR278C	YJL213W||S000003749|Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YMR272C	1.64727	YLR278C	YMR272C|SCS7|S000004885|Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YGR065C	1.63969	YLR278C	YGR065C|VHT1|S000003297|High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YDR377W	1.63454	YLR278C	YDR377W|ATP17|S000002785|Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YOR062C	1.62884	YLR278C	YOR062C||S000005588|Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YHR015W	1.62275	YLR278C	YHR015W|MIP6|S000001057|Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YML100W	1.61305	YLR278C	YML100W|TSL1|S000004566|Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YDR379C-A	1.59811	YLR278C	YDR379C-A||S000007605|Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YOR192C-C	1.58467	YLR278C	YOR192C-C||S000028857|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YEL075C	1.56222	YLR278C	YEL075C||S000000801|Putative protein of unknown function
YKR016W	1.56115	YLR278C	YKR016W|AIM28|S000001724|Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YDL139C	1.55436	YLR278C	YDL139C|SCM3|S000002298|Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YGL056C	1.5463	YLR278C	YGL056C|SDS23|S000003024|One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YLR001C	1.52671	YLR278C	YLR001C||S000003991|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR001C is not an essential gene
YMR103C	1.51967	YLR278C	YMR103C||S000004709|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR170C	1.50656	YLR278C	YMR170C|ALD2|S000004780|Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YOR084W	1.50416	YLR278C	YOR084W|LPX1|S000005610|Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
YDR178W	1.49591	YLR278C	YDR178W|SDH4|S000002585|Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YHR125W	1.49458	YLR278C	YHR125W||S000001167|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR292C	1.48747	YLR278C	YBR292C||S000000496|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YJR078W	1.48495	YLR278C	YJR078W|BNA2|S000003839|Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YJR150C	1.48445	YLR278C	YJR150C|DAN1|S000003911|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YLR054C	1.48165	YLR278C	YLR054C|OSW2|S000004044|Protein of unknown function proposed to be involved in the assembly of the spore wall
YJR061W	1.47889	YLR278C	YJR061W||S000003822|Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YDR104C	1.47739	YLR278C	YDR104C|SPO71|S000002511|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YMR158W-B	1.47247	YLR278C	YMR158W-B||S000004768|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
YFL036W	1.47019	YLR278C	YFL036W|RPO41|S000001858|Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YOR200W	1.46631	YLR278C	YOR200W||S000005726|Hypothetical protein
YNR001C	1.45959	YLR278C	YNR001C|CIT1|S000005284|Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YLR193C	1.45126	YLR278C	YLR193C|UPS1|S000004183|Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI
YDR476C	1.44962	YLR278C	YDR476C||S000002884|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YNL335W	1.44734	YLR278C	YNL335W|DDI3|S000005279|Hypothetical protein
YDR092W	1.44699	YLR278C	YDR092W|UBC13|S000002499|Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YDL183C	1.4457	YLR278C	YDL183C||S000002342|Putative protein of unknown function; YDL183C is not an essential gene
YOR072W	1.44517	YLR278C	YOR072W||S000005598|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YDR528W	1.44494	YLR278C	YDR528W|HLR1|S000002936|Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YER054C	1.43919	YLR278C	YER054C|GIP2|S000000856|Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YBR208C	1.43672	YLR278C	YBR208C|DUR1,2|S000000412|Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YGR213C	1.43482	YLR278C	YGR213C|RTA1|S000003445|Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YPL025C	1.43203	YLR278C	YPL025C||S000005946|Hypothetical protein
YGR244C	1.42571	YLR278C	YGR244C|LSC2|S000003476|Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YEL050C	1.41715	YLR278C	YEL050C|RML2|S000000776|Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YDR313C	1.41433	YLR278C	YDR313C|PIB1|S000002721|RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YDL243C	1.4024	YLR278C	YDL243C|AAD4|S000002402|Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YLR346C	1.39498	YLR278C	YLR346C||S000004338|Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YBR018C	1.39434	YLR278C	YBR018C|GAL7|S000000222|Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YLR278C	1.37797	YLR278C	YLR278C||S000004268|Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YIL122W	1.35902	YLR278C	YIL122W|POG1|S000001384|Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YKL217W	1.35889	YLR278C	YKL217W|JEN1|S000001700|Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YJR160C	1.34834	YLR278C	YJR160C|MPH3|S000003921|Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YFR047C	1.34375	YLR278C	YFR047C|BNA6|S000001943|Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YDR286C	1.33496	YLR278C	YDR286C||S000002694|Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
YNL237W	1.31973	YLR278C	YNL237W|YTP1|S000005181|Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
YOR059C	1.31607	YLR278C	YOR059C||S000005585|Hypothetical protein
YNL034W	1.314	YLR278C	YNL034W||S000004979|Putative protein of unknown function; YNL034W is not an essential gene
YDR096W	1.31332	YLR278C	YDR096W|GIS1|S000002503|JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YLL039C	1.31235	YLR278C	YLL039C|UBI4|S000003962|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YDR256C	1.29717	YLR278C	YDR256C|CTA1|S000002664|Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
YIL120W	1.27851	YLR278C	YIL120W|QDR1|S000001382|Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
YOR392W	1.27368	YLR278C	YOR392W||S000005919|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YOL154W	1.27245	YLR278C	YOL154W|ZPS1|S000005514|Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YNL328C	1.26279	YLR278C	YNL328C|MDJ2|S000005272|Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
YOR173W	1.2571	YLR278C	YOR173W|DCS2|S000005699|Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YJL056C	1.25247	YLR278C	YJL056C|ZAP1|S000003592|Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains
YCR021C	1.24235	YLR278C	YCR021C|HSP30|S000000615|Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YLR345W	1.24211	YLR278C	YLR345W||S000004337|Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
YEL052W	1.24043	YLR278C	YEL052W|AFG1|S000000778|Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YMR216C	1.23137	YLR278C	YMR216C|SKY1|S000004829|SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
YKL095W	1.23122	YLR278C	YKL095W|YJU2|S000001578|Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic reaction of splicing
YDR010C	1.22927	YLR278C	YDR010C||S000002417|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR087W	1.22039	YLR278C	YHR087W|RTC3|S000001129|Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YNR019W	1.22004	YLR278C	YNR019W|ARE2|S000005302|Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
YIL147C	1.20894	YLR278C	YIL147C|SLN1|S000001409|Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
YOR071C	1.20078	YLR278C	YOR071C|NRT1|S000005597|High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YDR258C	1.19721	YLR278C	YDR258C|HSP78|S000002666|Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YOL106W	1.18564	YLR278C	YOL106W||S000005466|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL096W	1.18204	YLR278C	YGL096W|TOS8|S000003064|Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YNL143C	1.18083	YLR278C	YNL143C||S000005087|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL083C	1.17029	YLR278C	YIL083C||S000001345|Putative phosphopantothenoylcysteine synthetase (PPCS) that catalyzes the second step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability
YOR011W-A	1.16906	YLR278C	YOR011W-A||S000028581|Putative protein of unknown function
YJL093C	1.15762	YLR278C	YJL093C|TOK1|S000003629|Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YNL250W	1.15498	YLR278C	YNL250W|RAD50|S000005194|Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
YDL222C	1.15353	YLR278C	YDL222C|FMP45|S000002381|Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YLR142W	1.13051	YLR278C	YLR142W|PUT1|S000004132|Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YCR068W	1.12915	YLR278C	YCR068W|ATG15|S000000664|Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YBR001C	1.12756	YLR278C	YBR001C|NTH2|S000000205|Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YGR070W	1.12721	YLR278C	YGR070W|ROM1|S000003302|GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YPR202W	1.12554	YLR278C	YPR202W||S000006406|Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
YLL013C	1.11668	YLR278C	YLL013C|PUF3|S000003936|Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YHL027W	1.11095	YLR278C	YHL027W|RIM101|S000001019|Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC
YER150W	1.10816	YLR278C	YER150W|SPI1|S000000952|GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YPR061C	1.10321	YLR278C	YPR061C|JID1|S000006265|Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YML081W	1.10231	YLR278C	YML081W||S000004546|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YGL162W	1.09711	YLR278C	YGL162W|SUT1|S000003130|Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YBL099W	1.09505	YLR278C	YBL099W|ATP1|S000000195|Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOR072W-A	1.09404	YLR278C	YOR072W-A||S000028582|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YDR275W	1.08872	YLR278C	YDR275W|BSC2|S000002683|Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YOR186C-A	1.08795	YLR278C	YOR186C-A||S000028715|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YIL036W	1.08781	YLR278C	YIL036W|CST6|S000001298|Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance
YLR228C	1.08719	YLR278C	YLR228C|ECM22|S000004218|Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YER158W-A	1.08259	YLR278C	YER158W-A||S000028624|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YNL187W	1.07651	YLR278C	YNL187W||S000005131|Putative protein of unknown function; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; may interact with or be fuctionally redundant with Prp40p
YKL150W	1.07487	YLR278C	YKL150W|MCR1|S000001633|Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
YOR053W	1.07474	YLR278C	YOR053W||S000005579|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
YJL220W	1.07433	YLR278C	YJL220W||S000003756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YDL007C-A	1.06874	YLR278C	YDL007C-A||S000113557|Putative protein of unknown function
YMR213W	1.06621	YLR278C	YMR213W|CEF1|S000004826|Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
YBR039W	1.06198	YLR278C	YBR039W|ATP3|S000000243|Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YKL004W	1.05593	YLR278C	YKL004W|AUR1|S000001487|Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
YDR490C	1.05455	YLR278C	YDR490C|PKH1|S000002898|Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
YIL155C	1.05089	YLR278C	YIL155C|GUT2|S000001417|Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YDR055W	1.04839	YLR278C	YDR055W|PST1|S000002462|Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YDR347W	1.04788	YLR278C	YDR347W|MRP1|S000002755|Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
YCL001W-A	1.04375	YLR278C	YCL001W-A||S000007221|Putative protein of unknown function; YCL001W-A is not an essential gene
YNL115C	1.04149	YLR278C	YNL115C||S000005059|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YKL142W	1.02688	YLR278C	YKL142W|MRP8|S000001625|Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2
YNL202W	1.02481	YLR278C	YNL202W|SPS19|S000005146|Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YBR076C-A	1.01833	YLR278C	YBR076C-A||S000028533|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YDR403W	1.01738	YLR278C	YDR403W|DIT1|S000002811|Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
YCR105W	1.01365	YLR278C	YCR105W|ADH7|S000000702|NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YDL238C	1.01163	YLR278C	YDL238C|GUD1|S000002397|Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YLR304C	1.00786	YLR278C	YLR304C|ACO1|S000004295|Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YDR034C	1.00431	YLR278C	YDR034C|LYS14|S000002441|Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YGL033W	1.00151	YLR278C	YGL033W|HOP2|S000003001|Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YKL005C	0.992184	YLR278C	YKL005C|BYE1|S000001488|Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
YCR010C	0.983074	YLR278C	YCR010C|ADY2|S000000603|Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YOL128C	0.980599	YLR278C	YOL128C|YGK3|S000005488|Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YNL305C	0.977991	YLR278C	YNL305C||S000005249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YBR222C	0.973842	YLR278C	YBR222C|PCS60|S000000426|Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YJL130C	0.97198	YLR278C	YJL130C|URA2|S000003666|Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YDR090C	0.966616	YLR278C	YDR090C||S000002497|Putative protein of unknown function
YGR023W	0.965608	YLR278C	YGR023W|MTL1|S000003255|Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YOR228C	0.957575	YLR278C	YOR228C||S000005754|Protein of unknown function, localized to the mitochondrial outer membrane
YDR244W	0.953561	YLR278C	YDR244W|PEX5|S000002652|Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
YKL175W	0.945769	YLR278C	YKL175W|ZRT3|S000001658|Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
YPL119C	0.942395	YLR278C	YPL119C|DBP1|S000006040|Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YJL221C	0.940584	YLR278C	YJL221C|FSP2|S000003757|Protein of unknown function, expression is induced during nitrogen limitation
YKL029C	0.937713	YLR278C	YKL029C|MAE1|S000001512|Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YMR104C	0.935261	YLR278C	YMR104C|YPK2|S000004710|Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YPR065W	0.933888	YLR278C	YPR065W|ROX1|S000006269|Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YJR052W	0.933519	YLR278C	YJR052W|RAD7|S000003813|Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YJL214W	0.933153	YLR278C	YJL214W|HXT8|S000003750|Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YLR281C	0.930518	YLR278C	YLR281C||S000004271|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
YAR019W-A	0.923391	YLR278C	YAR019W-A||S000028735|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL017C	0.92225	YLR278C	YNL017C||S000004962|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2
YEL009C-A	0.922131	YLR278C	YEL009C-A||S000028741|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR382C	0.921887	YLR278C	YLR382C|NAM2|S000004374|Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
YBR269C	0.919443	YLR278C	YBR269C|FMP21|S000000473|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR050W	0.913936	YLR278C	YHR050W|SMF2|S000001092|Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YGR022C	0.913638	YLR278C	YGR022C||S000003254|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YDR014W-A	0.912801	YLR278C	YDR014W-A|HED1|S000113613|Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YIR028W	0.911334	YLR278C	YIR028W|DAL4|S000001467|Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YKL141W	0.909592	YLR278C	YKL141W|SDH3|S000001624|Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YAR019C	0.90871	YLR278C	YAR019C|CDC15|S000000072|Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YJL219W	0.906398	YLR278C	YJL219W|HXT9|S000003755|Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
YPL272C	0.904851	YLR278C	YPL272C||S000006193|Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YHR155W	0.903108	YLR278C	YHR155W|YSP1|S000001198|Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone
YFR027W	0.900791	YLR278C	YFR027W|ECO1|S000001923|Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair
YPL111W	0.899022	YLR278C	YPL111W|CAR1|S000006032|Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YLR005W	0.891091	YLR278C	YLR005W|SSL1|S000003995|Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YGL192W	0.89048	YLR278C	YGL192W|IME4|S000003160|Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YHR092C	0.887244	YLR278C	YHR092C|HXT4|S000001134|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YLR280C	0.878656	YLR278C	YLR280C||S000004270|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL193C	0.878242	YLR278C	YGL193C||S000003161|Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YOR031W	0.873703	YLR278C	YOR031W|CRS5|S000005557|Copper-binding metallothionein, required for wild-type copper resistance
YOL081W	0.872958	YLR278C	YOL081W|IRA2|S000005441|GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YBR270C	0.87222	YLR278C	YBR270C|BIT2|S000000474|Hypothetical protein
YBR076W	0.868184	YLR278C	YBR076W|ECM8|S000000280|Non-essential protein of unknown function
YPL274W	0.862962	YLR278C	YPL274W|SAM3|S000006195|High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YOR199W	0.855811	YLR278C	YOR199W||S000005725|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR251W	0.854324	YLR278C	YLR251W|SYM1|S000004241|Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
YDL218W	0.853314	YLR278C	YDL218W||S000002377|Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YKL044W	0.844102	YLR278C	YKL044W||S000001527|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR008C	0.843596	YLR278C	YHR008C|SOD2|S000001050|Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YGR043C	0.838845	YLR278C	YGR043C|NQM1|S000003275|Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YBR132C	0.838366	YLR278C	YBR132C|AGP2|S000000336|High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YBR172C	0.838124	YLR278C	YBR172C|SMY2|S000000376|Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2
YNL197C	0.830308	YLR278C	YNL197C|WHI3|S000005141|RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
YBR224W	0.817379	YLR278C	YBR224W||S000000428|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
YDL013W	0.816247	YLR278C	YDL013W|SLX5|S000002171|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YHR049C-A	0.814446	YLR278C	YHR049C-A||S000003532|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL023W	0.814039	YLR278C	YFL023W|BUD27|S000001871|Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition
YJL047C	0.808596	YLR278C	YJL047C|RTT101|S000003583|Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p
YBL100C	0.798582	YLR278C	YBL100C||S000000196|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YOR363C	0.796528	YLR278C	YOR363C|PIP2|S000005890|Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes
YDR136C	0.788367	YLR278C	YDR136C|VPS61|S000002543|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
YDR001C	0.783172	YLR278C	YDR001C|NTH1|S000002408|Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YJR085C	0.769541	YLR278C	YJR085C||S000003845|Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL001W	0.769531	YLR278C	YOL001W|PHO80|S000005361|Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
YPR010C-A	0.768636	YLR278C	YPR010C-A||S000122558|Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YER047C	0.767938	YLR278C	YER047C|SAP1|S000000849|Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
YMR256C	0.766407	YLR278C	YMR256C|COX7|S000004869|Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YFR010W-A	0.76093	YLR278C	YFR010W-A||S000028824|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry
YIL024C	0.75789	YLR278C	YIL024C||S000001286|Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YDR494W	0.756615	YLR278C	YDR494W|RSM28|S000002902|Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
YDL174C	0.756206	YLR278C	YDL174C|DLD1|S000002333|D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YBR223C	0.751342	YLR278C	YBR223C|TDP1|S000000427|Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I
YKL192C	0.751249	YLR278C	YKL192C|ACP1|S000001675|Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YER014C-A	0.750882	YLR278C	YER014C-A|BUD25|S000007590|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YPL092W	0.744584	YLR278C	YPL092W|SSU1|S000006013|Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YGR250C	0.739928	YLR278C	YGR250C||S000003482|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLL060C	0.732686	YLR278C	YLL060C|GTT2|S000003983|Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YIL023C	0.730911	YLR278C	YIL023C|YKE4|S000001285|Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YPR160W	0.730231	YLR278C	YPR160W|GPH1|S000006364|Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YJR077C	0.729539	YLR278C	YJR077C|MIR1|S000003838|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YBR213W	0.723547	YLR278C	YBR213W|MET8|S000000417|Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YMR008C	0.72347	YLR278C	YMR008C|PLB1|S000004610|Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YLL029W	0.721844	YLR278C	YLL029W|FRA1|S000003952|Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YBR035C	0.709327	YLR278C	YBR035C|PDX3|S000000239|Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YBR297W	0.709106	YLR278C	YBR297W|MAL33|S000000501|MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YNL125C	0.708101	YLR278C	YNL125C|ESBP6|S000005069|Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YMR291W	0.706489	YLR278C	YMR291W||S000004905|Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene
YBR293W	0.705534	YLR278C	YBR293W|VBA2|S000000497|Permease of basic amino acids in the vacuolar membrane
YDR231C	0.697162	YLR278C	YDR231C|COX20|S000002639|Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YIL055C	0.696346	YLR278C	YIL055C||S000001317|Putative protein of unknown function
YDR264C	0.692274	YLR278C	YDR264C|AKR1|S000002672|Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
YOL147C	0.691349	YLR278C	YOL147C|PEX11|S000005507|Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements
YLR383W	0.691022	YLR278C	YLR383W|SMC6|S000004375|Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18
YJL217W	0.6904	YLR278C	YJL217W||S000003753|Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YJR148W	0.689792	YLR278C	YJR148W|BAT2|S000003909|Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YPL262W	0.685203	YLR278C	YPL262W|FUM1|S000006183|Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YHR180W	0.681294	YLR278C	YHR180W||S000001223|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL196W	0.678072	YLR278C	YGL196W|DSD1|S000003164|D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia; specifc for D-serine, unlike the bacterial enzyme which recognizes both D-serine and L-serine as substrates
YJL084C	0.677011	YLR278C	YJL084C|ALY2|S000003620|Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase
YJR147W	0.676595	YLR278C	YJR147W|HMS2|S000003908|Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YCR027C	0.676495	YLR278C	YCR027C|RHB1|S000000622|Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
YDR093W	0.67575	YLR278C	YDR093W|DNF2|S000002500|Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YOL052C	0.675651	YLR278C	YOL052C|SPE2|S000005412|S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YEL010W	0.674788	YLR278C	YEL010W||S000000736|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL239C	0.674155	YLR278C	YDL239C|ADY3|S000002398|Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p
YER033C	0.665431	YLR278C	YER033C|ZRG8|S000000835|Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YAL043C	0.656743	YLR278C	YAL043C|PTA1|S000000041|Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
YNL011C	0.654778	YLR278C	YNL011C||S000004956|Putative protein of unknown function; YNL011C is not an essential gene
YEL060C	0.648114	YLR278C	YEL060C|PRB1|S000000786|Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YLR289W	0.647873	YLR278C	YLR289W|GUF1|S000004280|Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans
YOR186W	0.647326	YLR278C	YOR186W||S000005712|Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YKL039W	0.645365	YLR278C	YKL039W|PTM1|S000001522|Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p
YDL120W	0.645247	YLR278C	YDL120W|YFH1|S000002278|Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia
YIR016W	0.644725	YLR278C	YIR016W||S000001455|Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR016W is a non-essential gene
YBR225W	0.644054	YLR278C	YBR225W||S000000429|Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
YHL043W	0.640245	YLR278C	YHL043W|ECM34|S000001035|Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YHR006W	0.640095	YLR278C	YHR006W|STP2|S000001048|Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YER103W	0.632298	YLR278C	YER103W|SSA4|S000000905|Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YAL034C	0.631506	YLR278C	YAL034C|FUN19|S000002134|Non-essential protein of unknown function
YAL028W	0.62935	YLR278C	YAL028W|FRT2|S000000026|Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YPR140W	0.622054	YLR278C	YPR140W|TAZ1|S000006344|Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome
YHR161C	0.620226	YLR278C	YHR161C|YAP1801|S000001204|Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family
YDR380W	0.616374	YLR278C	YDR380W|ARO10|S000002788|Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YMR210W	0.613236	YLR278C	YMR210W||S000004823|Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YDR169C	0.610178	YLR278C	YDR169C|STB3|S000002576|Protein that binds Sin3p in a two-hybrid assay
YDR281C	0.609049	YLR278C	YDR281C|PHM6|S000002689|Protein of unknown function, expression is regulated by phosphate levels
YOR010C	0.6089	YLR278C	YOR010C|TIR2|S000005536|Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YGR069W	0.608022	YLR278C	YGR069W||S000003301|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR230W	0.606108	YLR278C	YDR230W||S000002638|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
YOR064C	0.605984	YLR278C	YOR064C|YNG1|S000005590|Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
YLR121C	0.597267	YLR278C	YLR121C|YPS3|S000004111|Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YER088C	0.595908	YLR278C	YER088C|DOT6|S000000890|Protein of unknown function, involved in telomeric gene silencing and filamentation
YMR016C	0.595356	YLR278C	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YPR036W-A	0.592663	YLR278C	YPR036W-A||S000028425|Protein of unknown function; transcription is regulated by Pdr1p
YDR421W	0.580746	YLR278C	YDR421W|ARO80|S000002829|Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
YIL162W	0.580696	YLR278C	YIL162W|SUC2|S000001424|Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YKR058W	0.579207	YLR278C	YKR058W|GLG1|S000001766|Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YER060W-A	0.577014	YLR278C	YER060W-A|FCY22|S000002958|Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YHR099W	0.574963	YLR278C	YHR099W|TRA1|S000001141|Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
YDR173C	0.572471	YLR278C	YDR173C|ARG82|S000002580|Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YML128C	0.572154	YLR278C	YML128C|MSC1|S000004597|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YGR222W	0.571879	YLR278C	YGR222W|PET54|S000003454|Mitochondrial inner membrane protein that binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
YEL069C	0.570002	YLR278C	YEL069C|HXT13|S000000795|Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose
YDR381C-A	0.569304	YLR278C	YDR381C-A||S000007650|Protein of unknown function, localized to the mitochondrial outer membrane
YPL282C	0.563951	YLR278C	YPL282C|PAU22|S000006203|Hypothetical protein
YFR029W	0.563922	YLR278C	YFR029W|PTR3|S000001925|Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YER166W	0.562495	YLR278C	YER166W|DNF1|S000000968|Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YBL005W	0.561767	YLR278C	YBL005W|PDR3|S000000101|Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)
YBL102W	0.559488	YLR278C	YBL102W|SFT2|S000000198|Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YKL043W	0.556802	YLR278C	YKL043W|PHD1|S000001526|Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YBR105C	0.554347	YLR278C	YBR105C|VID24|S000000309|Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YPL067C	0.550132	YLR278C	YPL067C||S000005988|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
YOR134W	0.547933	YLR278C	YOR134W|BAG7|S000005660|Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p
YDL024C	0.546352	YLR278C	YDL024C|DIA3|S000002182|Protein of unknown function, involved in invasive and pseudohyphal growth
YBL001C	0.545388	YLR278C	YBL001C|ECM15|S000000097|Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
YDR265W	0.543768	YLR278C	YDR265W|PEX10|S000002673|C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to import machinery; mutations in human homolog cause various peroxisomal disorders
YNL100W	0.538828	YLR278C	YNL100W|AIM37|S000005044|Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YLL061W	0.535748	YLR278C	YLL061W|MMP1|S000003984|High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
YDL021W	0.534531	YLR278C	YDL021W|GPM2|S000002179|Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YKL032C	0.532899	YLR278C	YKL032C|IXR1|S000001515|Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YIL046W	0.531912	YLR278C	YIL046W|MET30|S000001308|F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
YDR402C	0.530745	YLR278C	YDR402C|DIT2|S000002810|N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s
YGL256W	0.530618	YLR278C	YGL256W|ADH4|S000003225|Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YER147C	0.527902	YLR278C	YER147C|SCC4|S000000949|Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YBR183W	0.52512	YLR278C	YBR183W|YPC1|S000000387|Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YBR056W	0.52476	YLR278C	YBR056W||S000000260|Putative cytoplasmic protein of unknown function
YOL151W	0.524621	YLR278C	YOL151W|GRE2|S000005511|3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YEL050W-A	0.522282	YLR278C	YEL050W-A||S000028545|Dubious open reading frame unlikely to encode a functional protein, identified by fungal homology and RT-PCR
YKL202W	0.522124	YLR278C	YKL202W||S000001685|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL224C	0.51842	YLR278C	YKL224C|PAU16|S000001707|Putative protein of unknown function
YDR204W	0.515246	YLR278C	YDR204W|COQ4|S000002612|Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
YMR068W	0.514049	YLR278C	YMR068W|AVO2|S000004672|Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YKR069W	0.513984	YLR278C	YKR069W|MET1|S000001777|S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YGR260W	0.513799	YLR278C	YGR260W|TNA1|S000003492|High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YNL276C	0.512403	YLR278C	YNL276C||S000005220|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W
YBR207W	0.51082	YLR278C	YBR207W|FTH1|S000000411|Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis
YBR280C	0.508325	YLR278C	YBR280C|SAF1|S000000484|F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YOL032W	0.507264	YLR278C	YOL032W|OPI10|S000005392|Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
YOR292C	0.505761	YLR278C	YOR292C||S000005818|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
YLR205C	0.502834	YLR278C	YLR205C|HMX1|S000004195|ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YKL197C	0.502356	YLR278C	YKL197C|PEX1|S000001680|AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
YGL072C	0.501674	YLR278C	YGL072C||S000003040|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YNL042W	0.49942	YLR278C	YNL042W|BOP3|S000004987|Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury
YDR511W	0.489464	YLR278C	YDR511W|ACN9|S000002919|Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
YNL241C	0.489403	YLR278C	YNL241C|ZWF1|S000005185|Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YOR394W	0.487341	YLR278C	YOR394W|PAU21|S000005921|Hypothetical protein
YDR335W	0.482832	YLR278C	YDR335W|MSN5|S000002743|Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP
YER187W	0.482162	YLR278C	YER187W||S000000989|Putative protein of unknown function; induced in respiratory-deficient cells
YGL136C	0.480855	YLR278C	YGL136C|MRM2|S000003104|Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
YER165C-A	0.479206	YLR278C	YER165C-A||S000028762|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W
YDR232W	0.478352	YLR278C	YDR232W|HEM1|S000002640|5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YPL261C	0.477864	YLR278C	YPL261C||S000006182|Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
YLR259C	0.477308	YLR278C	YLR259C|HSP60|S000004249|Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YKR071C	0.476786	YLR278C	YKR071C|DRE2|S000001779|Protein of unknown function required for sister chromatid cohesion; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2
YPL234C	0.473517	YLR278C	YPL234C|TFP3|S000006155|Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
YER078W-A	0.47042	YLR278C	YER078W-A||S000028546|Putative protein of unknown function; identified by fungal homology and RT-PCR
YOR364W	0.469542	YLR278C	YOR364W||S000005891|Hypothetical protein
YKR049C	0.468775	YLR278C	YKR049C|FMP46|S000001757|Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL240C	0.468639	YLR278C	YNL240C|NAR1|S000005184|Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YPR120C	0.466792	YLR278C	YPR120C|CLB5|S000006324|B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YAR027W	0.464144	YLR278C	YAR027W|UIP3|S000000075|Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YOR346W	0.463119	YLR278C	YOR346W|REV1|S000005873|Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YDL237W	0.456025	YLR278C	YDL237W|LRC1|S000002396|Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YIL060W	0.455472	YLR278C	YIL060W||S000001322|Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YMR280C	0.454124	YLR278C	YMR280C|CAT8|S000004893|Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YNL105W	0.452864	YLR278C	YNL105W||S000005049|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene INP52
YGR129W	0.452135	YLR278C	YGR129W|SYF2|S000003361|Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression
YNL288W	0.449127	YLR278C	YNL288W|CAF40|S000005232|Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
YDL015C	0.448972	YLR278C	YDL015C|TSC13|S000002173|Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
YOR007C	0.448913	YLR278C	YOR007C|SGT2|S000005533|Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70
YPL089C	0.447404	YLR278C	YPL089C|RLM1|S000006010|MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YDR142C	0.446761	YLR278C	YDR142C|PEX7|S000002549|Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
YLR135W	0.446522	YLR278C	YLR135W|SLX4|S000004125|Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YDL127W	0.444085	YLR278C	YDL127W|PCL2|S000002285|G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth
YGL203C	0.439928	YLR278C	YGL203C|KEX1|S000003171|Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
YOR345C	0.432844	YLR278C	YOR345C||S000005872|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YHR131W-A	0.427108	YLR278C	YHR131W-A||S000028782|Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YHR131C
YGL064C	0.425807	YLR278C	YGL064C|MRH4|S000003032|Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YMR023C	0.421598	YLR278C	YMR023C|MSS1|S000004625|Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
YPR172W	0.417056	YLR278C	YPR172W||S000006376|Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YGR101W	0.411966	YLR278C	YGR101W|PCP1|S000003333|Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
YLR246W	0.409852	YLR278C	YLR246W|ERF2|S000004236|Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole
YIL082W	0.408096	YLR278C	YIL082W||S000001344|Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
YBR291C	0.406616	YLR278C	YBR291C|CTP1|S000000495|Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YGL194C	0.40424	YLR278C	YGL194C|HOS2|S000003162|Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YLL051C	0.402026	YLR278C	YLL051C|FRE6|S000003974|Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YLR037C	0.401262	YLR278C	YLR037C|DAN2|S000004027|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YAL048C	0.400935	YLR278C	YAL048C|GEM1|S000000046|Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death
YMR279C	0.400615	YLR278C	YMR279C||S000004892|Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YKR095W	0.399598	YLR278C	YKR095W|MLP1|S000001803|Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YMR089C	0.397512	YLR278C	YMR089C|YTA12|S000004695|Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YAL047W-A	0.396001	YLR278C	YAL047W-A||S000028733|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR042C	0.395954	YLR278C	YDR042C||S000002449|Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YCR097W-A	0.394614	YLR278C	YCR097W-A||S000007632|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein
YPR096C	0.391168	YLR278C	YPR096C||S000006300|Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YBR120C	0.384402	YLR278C	YBR120C|CBP6|S000000324|Mitochondrial translational activator of the COB mRNA; phosphorylated
YDR242W	0.382191	YLR278C	YDR242W|AMD2|S000002650|Putative amidase
YLR425W	0.380828	YLR278C	YLR425W|TUS1|S000004417|Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YBL086C	0.378111	YLR278C	YBL086C||S000000182|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YBR083W	0.375066	YLR278C	YBR083W|TEC1|S000000287|Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YOR365C	0.373717	YLR278C	YOR365C||S000005892|Putative protein of unknown function; YOR365C is not an essential protein
YDL140C	0.372978	YLR278C	YDL140C|RPO21|S000002299|RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YDL020C	0.370454	YLR278C	YDL020C|RPN4|S000002178|Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YMR243C	0.366786	YLR278C	YMR243C|ZRC1|S000004856|Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
YEL019C	0.362863	YLR278C	YEL019C|MMS21|S000000745|SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
YGL104C	0.360789	YLR278C	YGL104C|VPS73|S000003072|Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YPR064W	0.360395	YLR278C	YPR064W||S000006268|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJR153W	0.359429	YLR278C	YJR153W|PGU1|S000003914|Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YKL223W	0.359191	YLR278C	YKL223W||S000001706|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR109W-A	0.357155	YLR278C	YBR109W-A||S000028737|Putative protein of unknown function; questionable ORF from MIPS
YDR259C	0.356948	YLR278C	YDR259C|YAP6|S000002667|Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YHR024C	0.353701	YLR278C	YHR024C|MAS2|S000001066|Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YNL329C	0.352134	YLR278C	YNL329C|PEX6|S000005273|AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol
YKL161C	0.350676	YLR278C	YKL161C||S000001644|Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YCR061W	0.35064	YLR278C	YCR061W||S000000657|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR052W	0.348739	YLR278C	YMR052W|FAR3|S000004656|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p
YBL103C	0.342884	YLR278C	YBL103C|RTG3|S000000199|Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
YPR159W	0.34125	YLR278C	YPR159W|KRE6|S000006363|Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p
YDL010W	0.340904	YLR278C	YDL010W|GRX6|S000002168|Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YLL062C	0.340423	YLR278C	YLL062C|MHT1|S000003985|S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YEL064C	0.340282	YLR278C	YEL064C|AVT2|S000000790|Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YJL046W	0.339004	YLR278C	YJL046W|AIM22|S000003582|Putative lipoate-protein ligase A family member; null mutant displays respiratory growth defect, decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YKL133C	0.33773	YLR278C	YKL133C||S000001616|Putative protein of unknown function
YBR185C	0.337594	YLR278C	YBR185C|MBA1|S000000389|Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane
YPL187W	0.336645	YLR278C	YPL187W|MF(ALPHA)1|S000006108|Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YDL011C	0.331823	YLR278C	YDL011C||S000002169|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YGR137W	0.331234	YLR278C	YGR137W||S000003369|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR323C	0.329379	YLR278C	YLR323C|CWC24|S000004315|Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p
YPR141C	0.32915	YLR278C	YPR141C|KAR3|S000006345|Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
YNL285W	0.328683	YLR278C	YNL285W||S000005229|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL229C	0.326088	YLR278C	YGL229C|SAP4|S000003198|Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
YIR040C	0.32576	YLR278C	YIR040C||S000001479|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YKR067W	0.325373	YLR278C	YKR067W|GPT2|S000001775|Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YPR095C	0.320057	YLR278C	YPR095C|SYT1|S000006299|Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family
YHL021C	0.318106	YLR278C	YHL021C|AIM17|S000001013|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YBR150C	0.31718	YLR278C	YBR150C|TBS1|S000000354|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR028C	0.317033	YLR278C	YCR028C|FEN2|S000000623|Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph
YIR001C	0.314951	YLR278C	YIR001C|SGN1|S000001440|Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
YIR006C	0.313875	YLR278C	YIR006C|PAN1|S000001445|Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
YPL088W	0.31029	YLR278C	YPL088W||S000006009|Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YOR257W	0.309553	YLR278C	YOR257W|CDC31|S000005783|Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
YGL090W	0.309409	YLR278C	YGL090W|LIF1|S000003058|Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
YOR237W	0.309365	YLR278C	YOR237W|HES1|S000005763|Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)
YLR097C	0.308281	YLR278C	YLR097C|HRT3|S000004087|Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
YHR147C	0.307657	YLR278C	YHR147C|MRPL6|S000001190|Mitochondrial ribosomal protein of the large subunit
YPL260W	0.30573	YLR278C	YPL260W||S000006181|Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene
YIL014C-A	0.3055	YLR278C	YIL014C-A||S000003536|Putative protein of unknown function
YDR419W	0.305486	YLR278C	YDR419W|RAD30|S000002827|DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins
YPR138C	0.305443	YLR278C	YPR138C|MEP3|S000006342|Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
YKL198C	0.304494	YLR278C	YKL198C|PTK1|S000001681|Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YPR193C	0.303526	YLR278C	YPR193C|HPA2|S000006397|Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YER111C	0.300815	YLR278C	YER111C|SWI4|S000000913|DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YOR366W	0.295932	YLR278C	YOR366W||S000005893|Hypothetical protein
YOL126C	0.295877	YLR278C	YOL126C|MDH2|S000005486|Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
YCR001W	0.293352	YLR278C	YCR001W||S000000594|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
YBR094W	0.292809	YLR278C	YBR094W|PBY1|S000000298|Putative tubulin tyrosine ligase associated with P-bodies
YPL159C	0.292685	YLR278C	YPL159C|PET20|S000006080|Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
YBL017C	0.292192	YLR278C	YBL017C|PEP1|S000000113|Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YAL002W	0.287835	YLR278C	YAL002W|VPS8|S000000002|Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
YER186C	0.285301	YLR278C	YER186C||S000000988|Putative protein of unknown function
YGL083W	0.285227	YLR278C	YGL083W|SCY1|S000003051|Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
YDR135C	0.282842	YLR278C	YDR135C|YCF1|S000002542|Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR
YKL094W	0.276509	YLR278C	YKL094W|YJU3|S000001577|Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles
YGL254W	0.276508	YLR278C	YGL254W|FZF1|S000003223|Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers
YER163C	0.275984	YLR278C	YER163C||S000000965|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKL220C	0.272343	YLR278C	YKL220C|FRE2|S000001703|Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
YGR109C	0.272331	YLR278C	YGR109C|CLB6|S000003341|B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
YER020W	0.270582	YLR278C	YER020W|GPA2|S000000822|Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YHR106W	0.268501	YLR278C	YHR106W|TRR2|S000001148|Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD
YGL089C	0.266565	YLR278C	YGL089C|MF(ALPHA)2|S000003057|Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YER075C	0.266224	YLR278C	YER075C|PTP3|S000000877|Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YPR009W	0.264754	YLR278C	YPR009W|SUT2|S000006213|Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YBR036C	0.261711	YLR278C	YBR036C|CSG2|S000000240|Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
YGR194C	0.261475	YLR278C	YGR194C|XKS1|S000003426|Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
YEL072W	0.258309	YLR278C	YEL072W|RMD6|S000000798|Protein required for sporulation
YJR107W	0.256779	YLR278C	YJR107W||S000003868|Putative protein of unknown function; has sequence or structural similarity to lipases
YOR187W	0.256727	YLR278C	YOR187W|TUF1|S000005713|Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
YPR011C	0.254304	YLR278C	YPR011C||S000006215|Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR396C	0.251277	YLR278C	YLR396C|VPS33|S000004388|ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
YML009C-A	0.249237	YLR278C	YML009C-A||S000004469|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL106C	0.244294	YLR278C	YNL106C|INP52|S000005050|Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
YHR104W	0.244235	YLR278C	YHR104W|GRE3|S000001146|Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YLR352W	0.24282	YLR278C	YLR352W||S000004344|Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
YOR358W	0.241823	YLR278C	YOR358W|HAP5|S000005885|Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
YBR115C	0.241689	YLR278C	YBR115C|LYS2|S000000319|Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
YJL092W	0.241254	YLR278C	YJL092W|SRS2|S000003628|DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
YKL203C	0.239962	YLR278C	YKL203C|TOR2|S000001686|PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
YNL308C	0.238949	YLR278C	YNL308C|KRI1|S000005252|Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p
YBL037W	0.237183	YLR278C	YBL037W|APL3|S000000133|Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
YFL018C	0.236323	YLR278C	YFL018C|LPD1|S000001876|Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
YBR294W	0.235813	YLR278C	YBR294W|SUL1|S000000498|High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YBR251W	0.235619	YLR278C	YBR251W|MRPS5|S000000455|Mitochondrial ribosomal protein of the small subunit
YDR011W	0.23322	YLR278C	YDR011W|SNQ2|S000002418|Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
YGL071W	0.230812	YLR278C	YGL071W|AFT1|S000003039|Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YGL143C	0.227776	YLR278C	YGL143C|MRF1|S000003111|Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
YDL012C	0.227596	YLR278C	YDL012C||S000002170|Plasma membrane protein of unknown function; YDL012C is not an essential gene
YNL160W	0.227201	YLR278C	YNL160W|YGP1|S000005104|Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YCR067C	0.226947	YLR278C	YCR067C|SED4|S000000663|Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p
YLL025W	0.226159	YLR278C	YLL025W|PAU17|S000003948|Putative protein of unknown function; YLL025W is not an essential gene
YLR258W	0.225577	YLR278C	YLR258W|GSY2|S000004248|Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YNR071C	0.224885	YLR278C	YNR071C||S000005354|Putative protein of unknown function
YLL047W	0.223105	YLR278C	YLL047W||S000003970|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
YGL119W	0.222933	YLR278C	YGL119W|ABC1|S000003087|Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis
YER067W	0.222616	YLR278C	YER067W||S000000869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YML009W-B	0.221257	YLR278C	YML009W-B||S000004471|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
YCL056C	0.221209	YLR278C	YCL056C||S000000561|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBL029C-A	0.220025	YLR278C	YBL029C-A||S000007591|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
YPL061W	0.219133	YLR278C	YPL061W|ALD6|S000005982|Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YPL233W	0.218483	YLR278C	YPL233W|NSL1|S000006154|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YOR386W	0.217757	YLR278C	YOR386W|PHR1|S000005913|DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
YPR003C	0.215728	YLR278C	YPR003C||S000006207|Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
YMR240C	0.215579	YLR278C	YMR240C|CUS1|S000004853|Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
YDR446W	0.21313	YLR278C	YDR446W|ECM11|S000002854|Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YKL054C	0.213027	YLR278C	YKL054C|DEF1|S000001537|RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
YDL142C	0.212868	YLR278C	YDL142C|CRD1|S000002301|Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function
YDR440W	0.212468	YLR278C	YDR440W|DOT1|S000002848|Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization
YKR066C	0.211527	YLR278C	YKR066C|CCP1|S000001774|Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YFR007W	0.209078	YLR278C	YFR007W|YFH7|S000001903|Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YBR065C	0.208755	YLR278C	YBR065C|ECM2|S000000269|Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
YGR143W	0.208158	YLR278C	YGR143W|SKN1|S000003375|Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
YKL176C	0.208074	YLR278C	YKL176C|LST4|S000001659|Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YGL084C	0.204338	YLR278C	YGL084C|GUP1|S000003052|Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
YHR178W	0.203701	YLR278C	YHR178W|STB5|S000001221|Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay
YMR101C	0.202828	YLR278C	YMR101C|SRT1|S000004707|Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
YOR360C	0.200441	YLR278C	YOR360C|PDE2|S000005887|High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
YGR039W	0.199374	YLR278C	YGR039W||S000003271|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YKR014C	0.198506	YLR278C	YKR014C|YPT52|S000001722|GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YER115C	0.193669	YLR278C	YER115C|SPR6|S000000917|Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
YEL044W	0.191109	YLR278C	YEL044W|IES6|S000000770|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YBR193C	0.187174	YLR278C	YBR193C|MED8|S000000397|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YOR376W	0.186235	YLR278C	YOR376W||S000005903|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YLR055C	0.186187	YLR278C	YLR055C|SPT8|S000004045|Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YGR009C	0.185435	YLR278C	YGR009C|SEC9|S000003241|t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
YKL061W	0.184943	YLR278C	YKL061W||S000001544|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome
YLR113W	0.184573	YLR278C	YLR113W|HOG1|S000004103|Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YDL049C	0.184167	YLR278C	YDL049C|KNH1|S000002207|Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant
YDR097C	0.183959	YLR278C	YDR097C|MSH6|S000002504|Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
YIL050W	0.180833	YLR278C	YIL050W|PCL7|S000001312|Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YNL139C	0.180273	YLR278C	YNL139C|THO2|S000005083|Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
YAL021C	0.177657	YLR278C	YAL021C|CCR4|S000000019|Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
YKL121W	0.176467	YLR278C	YKL121W||S000001604|Putative protein of unknown function
YLL059C	0.174766	YLR278C	YLL059C||S000003982|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL138C	0.174503	YLR278C	YKL138C|MRPL31|S000001621|Mitochondrial ribosomal protein of the large subunit
YCL016C	0.174127	YLR278C	YCL016C|DCC1|S000000521|Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
YDL124W	0.171769	YLR278C	YDL124W||S000002282|NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YIL022W	0.17144	YLR278C	YIL022W|TIM44|S000001284|Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane
YPR097W	0.170773	YLR278C	YPR097W||S000006301|Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL063W	0.169298	YLR278C	YGL063W|PUS2|S000003031|Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
YLL030C	0.169183	YLR278C	YLL030C||S000003953|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL054W	0.162799	YLR278C	YIL054W||S000001316|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL143C	0.158636	YLR278C	YOL143C|RIB4|S000005503|Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
YPL109C	0.156193	YLR278C	YPL109C||S000006030|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL068W	0.155326	YLR278C	YFL068W||S000001826|Putative protein of unknown function
YOR149C	0.154449	YLR278C	YOR149C|SMP3|S000005675|Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
YBR110W	0.153109	YLR278C	YBR110W|ALG1|S000000314|Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
YBR054W	0.152994	YLR278C	YBR054W|YRO2|S000000258|Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YKR068C	0.151153	YLR278C	YKR068C|BET3|S000001776|Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
YGR003W	0.148893	YLR278C	YGR003W|CUL3|S000003235|Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21
YDR222W	0.147365	YLR278C	YDR222W||S000002630|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL160W	0.146574	YLR278C	YKL160W|ELF1|S000001643|Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
YML004C	0.145089	YLR278C	YML004C|GLO1|S000004463|Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
YMR077C	0.141999	YLR278C	YMR077C|VPS20|S000004682|Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
YDL221W	0.141959	YLR278C	YDL221W||S000002380|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
YNL278W	0.141345	YLR278C	YNL278W|CAF120|S000005222|Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YHR093W	0.139497	YLR278C	YHR093W|AHT1|S000001135|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YDR168W	0.136992	YLR278C	YDR168W|CDC37|S000002575|Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
YLR140W	0.136435	YLR278C	YLR140W||S000004130|Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YML116W-A	0.135808	YLR278C	YML116W-A||S000004586|Putative protein of unknown function
YLR176C	0.135116	YLR278C	YLR176C|RFX1|S000004166|Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
YLR059C	0.133913	YLR278C	YLR059C|REX2|S000004049|RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
YGL043W	0.133007	YLR278C	YGL043W|DST1|S000003011|General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
YFL067W	0.132401	YLR278C	YFL067W||S000001827|Protein of unknown function, down-regulated at low calcium levels
YDL025C	0.131985	YLR278C	YDL025C||S000002183|Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YDL131W	0.131684	YLR278C	YDL131W|LYS21|S000002289|Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p
YIL013C	0.131591	YLR278C	YIL013C|PDR11|S000001275|ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth
YOL004W	0.130756	YLR278C	YOL004W|SIN3|S000005364|Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
YGL044C	0.12921	YLR278C	YGL044C|RNA15|S000003012|Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p
YPL257W	0.129186	YLR278C	YPL257W||S000006178|Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YGL057C	0.128802	YLR278C	YGL057C||S000003025|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source
YGR254W	0.128482	YLR278C	YGR254W|ENO1|S000003486|Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YGL198W	0.126975	YLR278C	YGL198W|YIP4|S000003166|Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YNR031C	0.125416	YLR278C	YNR031C|SSK2|S000005314|MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
YGR230W	0.125294	YLR278C	YGR230W|BNS1|S000003462|Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
YNL177C	0.123835	YLR278C	YNL177C|MRPL22|S000005121|Mitochondrial ribosomal protein of the large subunit
YGL129C	0.123551	YLR278C	YGL129C|RSM23|S000003097|Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
YKL071W	0.123293	YLR278C	YKL071W||S000001554|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL082C	0.121038	YLR278C	YKL082C|RRP14|S000001565|Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
YAL044W-A	0.120531	YLR278C	YAL044W-A||S000007586|Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
YLR153C	0.119359	YLR278C	YLR153C|ACS2|S000004143|Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YKR022C	0.117825	YLR278C	YKR022C|NTR2|S000001730|Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YOR150W	0.113054	YLR278C	YOR150W|MRPL23|S000005676|Mitochondrial ribosomal protein of the large subunit
YOR250C	0.112905	YLR278C	YOR250C|CLP1|S000005776|Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
YBR194W	0.111841	YLR278C	YBR194W|AIM4|S000000398|Protein proposed to be associated with the nuclear pore complex; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and a severe growth defect in minimal glycerol media
YBR262C	0.110816	YLR278C	YBR262C|AIM5|S000000466|Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media
YJL083W	0.109678	YLR278C	YJL083W|TAX4|S000003619|EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS
YLR138W	0.109589	YLR278C	YLR138W|NHA1|S000004128|Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
YBL042C	0.109112	YLR278C	YBL042C|FUI1|S000000138|High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport
YKR076W	0.109057	YLR278C	YKR076W|ECM4|S000001784|Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR308W	0.10881	YLR278C	YLR308W|CDA2|S000004299|Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YMR294W-A	0.108084	YLR278C	YMR294W-A||S000004909|Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents
YOR032C	0.107233	YLR278C	YOR032C|HMS1|S000005558|Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YKL187C	0.107232	YLR278C	YKL187C||S000001670|Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
YHR028W-A	0.106534	YLR278C	YHR028W-A||S000028776|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR002C	0.10626	YLR278C	YGR002C|SWC4|S000003234|Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
YGR068C	0.105174	YLR278C	YGR068C||S000003300|Putative protein of unknown function; YGR068C is not an essential gene.
YLR040C	0.103662	YLR278C	YLR040C||S000004030|Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential
YMR292W	0.096181	YLR278C	YMR292W|GOT1|S000004906|Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p
YBR274W	0.096179	YLR278C	YBR274W|CHK1|S000000478|Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
YDR436W	0.0959356	YLR278C	YDR436W|PPZ2|S000002844|Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YLR255C	0.0958562	YLR278C	YLR255C||S000004245|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR041W	0.0953289	YLR278C	YLR041W||S000004031|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C
YML003W	0.0942501	YLR278C	YML003W||S000004462|Putative protein of unknown function
YGL091C	0.0928444	YLR278C	YGL091C|NBP35|S000003059|Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
YER164W	0.0923374	YLR278C	YER164W|CHD1|S000000966|Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes
YDL097C	0.0909645	YLR278C	YDL097C|RPN6|S000002255|Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
YIL012W	0.0900234	YLR278C	YIL012W||S000001274|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL013C	0.089332	YLR278C	YOL013C|HRD1|S000005373|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
YKL003C	0.0891441	YLR278C	YKL003C|MRP17|S000001486|Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
YOR006C	0.0885872	YLR278C	YOR006C|TSR3|S000005532|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; Null mutant accumulates 20S pre-rRNA
YGR010W	0.0851752	YLR278C	YGR010W|NMA2|S000003242|Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+)
YBR186W	0.0851391	YLR278C	YBR186W|PCH2|S000000390|Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA
YML116W	0.0826232	YLR278C	YML116W|ATR1|S000004584|Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide
YDR026C	0.0821832	YLR278C	YDR026C||S000002433|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p
YLR187W	0.0766577	YLR278C	YLR187W|SKG3|S000004177|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p
YKL165C-A	0.0737174	YLR278C	YKL165C-A||S000007617|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR014W	0.0729521	YLR278C	YHR014W|SPO13|S000001056|Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
YHR022C	0.0722382	YLR278C	YHR022C||S000001064|Putative protein of unknown function; YHR022C is not an essential gene.
YHR028C	0.0722029	YLR278C	YHR028C|DAP2|S000001070|Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
YDR445C	0.0690815	YLR278C	YDR445C||S000002853|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR301W	0.0686088	YLR278C	YBR301W|DAN3|S000000505|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YDR061W	0.068099	YLR278C	YDR061W||S000002468|Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YIR038C	0.0680673	YLR278C	YIR038C|GTT1|S000001477|ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
YAL067W-A	0.0679887	YLR278C	YAL067W-A||S000028593|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDL141W	0.0674861	YLR278C	YDL141W|BPL1|S000002300|Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
YML122C	0.0673823	YLR278C	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL096W	0.0668197	YLR278C	YJL096W|MRPL49|S000003632|Mitochondrial ribosomal protein of the large subunit
YBR273C	0.0667042	YLR278C	YBR273C|UBX7|S000000477|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YDR229W	0.0653759	YLR278C	YDR229W|IVY1|S000002637|Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
YKL002W	0.0649649	YLR278C	YKL002W|DID4|S000001485|Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
YOR256C	0.0648849	YLR278C	YOR256C|TRE2|S000005782|Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31
YLR260W	0.0628533	YLR278C	YLR260W|LCB5|S000004250|Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YLR034C	0.0621124	YLR278C	YLR034C|SMF3|S000004024|Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins
YOR268C	0.0611269	YLR278C	YOR268C||S000005794|Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
YDR140W	0.060842	YLR278C	YDR140W|MTQ2|S000002547|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC
YJL055W	0.060562	YLR278C	YJL055W||S000003591|Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
YGL177W	0.0601783	YLR278C	YGL177W||S000003145|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR082C	0.0588593	YLR278C	YBR082C|UBC4|S000000286|Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YBR220C	0.0575471	YLR278C	YBR220C||S000000424|Putative protein of unknown function; YBR220C is not an essential gene
YNL138W-A	0.056195	YLR278C	YNL138W-A|YSF3|S000028509|Component of the U2 snRNP, associated with the SF3b complex; conserved in Ashbya gossypii
YJL098W	0.055893	YLR278C	YJL098W|SAP185|S000003634|Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
YDL045W-A	0.0555141	YLR278C	YDL045W-A|MRP10|S000006430|Mitochondrial ribosomal protein of the small subunit
YML070W	0.0544378	YLR278C	YML070W|DAK1|S000004535|Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YER145C	0.0536944	YLR278C	YER145C|FTR1|S000000947|High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron
YFR057W	0.053056	YLR278C	YFR057W||S000001953|Putative protein of unknown function
YNL042W-B	0.0509781	YLR278C	YNL042W-B||S000028850|Putative protein of unknown function
YKR052C	0.050888	YLR278C	YKR052C|MRS4|S000001760|Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YNL124W	0.0505122	YLR278C	YNL124W|NAF1|S000005068|Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
YNL219C	0.0489354	YLR278C	YNL219C|ALG9|S000005163|Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
YAL046C	0.0484545	YLR278C	YAL046C|AIM1|S000000044|Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YJR051W	0.0481588	YLR278C	YJR051W|OSM1|S000003812|Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity
YBR219C	0.0472176	YLR278C	YBR219C||S000000423|Putative protein of unknown function; YBR219C is not an essential gene
YHR131C	0.0467578	YLR278C	YHR131C||S000001173|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR114W	0.0466068	YLR278C	YBR114W|RAD16|S000000318|Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YGL150C	0.0462754	YLR278C	YGL150C|INO80|S000003118|ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases
YDR349C	0.045479	YLR278C	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YDR029W	0.0447327	YLR278C	YDR029W||S000002436|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YNL073W	0.0429907	YLR278C	YNL073W|MSK1|S000005017|Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
YJR134C	0.0427694	YLR278C	YJR134C|SGM1|S000003895|Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
YLR288C	0.0416315	YLR278C	YLR288C|MEC3|S000004279|DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
YGR150C	0.041218	YLR278C	YGR150C|DMR1|S000003382|Protein of unknown function, contains PPR motifs; mutant has growth defects on both non-fermentable carbon sources and rich medium; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR033C	0.0391499	YLR278C	YGR033C|TIM21|S000003265|Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes
YER095W	0.0389735	YLR278C	YER095W|RAD51|S000000897|Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
YEL045C	0.0384444	YLR278C	YEL045C||S000000771|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YKL137W	0.0383964	YLR278C	YKL137W|CMC1|S000001620|Evolutionarily conserved copper-binding protein of the mitochondrial inner membrane, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
YOL006C	0.0357682	YLR278C	YOL006C|TOP1|S000005366|Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YEL046C	0.034264	YLR278C	YEL046C|GLY1|S000000772|Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YOR344C	0.0334839	YLR278C	YOR344C|TYE7|S000005871|Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YOL105C	0.0332459	YLR278C	YOL105C|WSC3|S000005465|Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis
YNR032W	0.031446	YLR278C	YNR032W|PPG1|S000005315|Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
YPL016W	0.0311592	YLR278C	YPL016W|SWI1|S000005937|Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can become prion [SWI+]
YJL165C	0.0310079	YLR278C	YJL165C|HAL5|S000003701|Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters
YLR275W	0.0265685	YLR278C	YLR275W|SMD2|S000004265|Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YGL168W	0.0244412	YLR278C	YGL168W|HUR1|S000003136|Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
YNL306W	0.0233225	YLR278C	YNL306W|MRPS18|S000005250|Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
YLR139C	0.0231936	YLR278C	YLR139C|SLS1|S000004129|Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
YDR523C	0.0227094	YLR278C	YDR523C|SPS1|S000002931|Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
YKL068W	0.0219477	YLR278C	YKL068W|NUP100|S000001551|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YLR010C	0.021268	YLR278C	YLR010C|TEN1|S000004000|Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YOR072W-B	0.0207683	YLR278C	YOR072W-B||S000028516|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YBR053C	0.0188024	YLR278C	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YNR006W	0.0186278	YLR278C	YNR006W|VPS27|S000005289|Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
YJR090C	0.0183338	YLR278C	YJR090C|GRR1|S000003850|F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
YOR002W	0.0181496	YLR278C	YOR002W|ALG6|S000005528|Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
YEL073C	0.0178064	YLR278C	YEL073C||S000000799|Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline
YCL014W	0.0175274	YLR278C	YCL014W|BUD3|S000000520|Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
YIL095W	0.0163186	YLR278C	YIL095W|PRK1|S000001357|Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
YML007W	0.0160964	YLR278C	YML007W|YAP1|S000004466|Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
YDL154W	0.0147134	YLR278C	YDL154W|MSH5|S000002313|Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
YNL286W	0.0146205	YLR278C	YNL286W|CUS2|S000005230|Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
YGR161C	0.00827032	YLR278C	YGR161C|RTS3|S000003393|Putative component of the protein phosphatase type 2A complex
YNL279W	0.00619972	YLR278C	YNL279W|PRM1|S000005223|Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
YNL041C	0.00569212	YLR278C	YNL041C|COG6|S000004986|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YJL186W	0.00446312	YLR278C	YJL186W|MNN5|S000003722|Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YBR271W	0.00442395	YLR278C	YBR271W||S000000475|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene
YCR066W	0.00437507	YLR278C	YCR066W|RAD18|S000000662|Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif
YPL064C	0.00391081	YLR278C	YPL064C|CWC27|S000005985|Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p
YOR032W-A	0.00188959	YLR278C	YOR032W-A||S000028710|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKR050W	0.000212836	YLR278C	YKR050W|TRK2|S000001758|Component of the Trk1p-Trk2p potassium transport system
