YDR044W	0.616016	YPR015C	YDR044W|HEM13|S000002451|Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YLR154W-A	0.522549	YPR015C	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B	0.484993	YPR015C	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YDR033W	0.48086	YPR015C	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YNR001W-A	0.475323	YPR015C	YNR001W-A||S000007625|Dubious open reading frame unlikely to encode a functional protein; identified by homology
YBR158W	0.436707	YPR015C	YBR158W|AMN1|S000000362|Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YOR107W	0.433801	YPR015C	YOR107W|RGS2|S000005633|Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YCL049C	0.399046	YPR015C	YCL049C||S000000554|Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YIR021W	0.379006	YPR015C	YIR021W|MRS1|S000001460|Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YLR314C	0.364778	YPR015C	YLR314C|CDC3|S000004306|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YPR157W	0.364268	YPR015C	YPR157W||S000006361|Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR083W	0.363094	YPR015C	YMR083W|ADH3|S000004688|Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YIL009W	0.323569	YPR015C	YIL009W|FAA3|S000001271|Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YKL164C	0.321003	YPR015C	YKL164C|PIR1|S000001647|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YNL066W	0.312347	YPR015C	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YLR413W	0.305176	YPR015C	YLR413W||S000004405|Putative protein of unknown function; YLR413W is not an essential gene
YLR312W-A	0.301258	YPR015C	YLR312W-A|MRPL15|S000004304|Mitochondrial ribosomal protein of the large subunit
YLR206W	0.287521	YPR015C	YLR206W|ENT2|S000004196|Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YMR106C	0.286155	YPR015C	YMR106C|YKU80|S000004712|Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YIL009C-A	0.284956	YPR015C	YIL009C-A|EST3|S000006432|Component of the telomerase holoenzyme, involved in telomere replication
YGL097W	0.279658	YPR015C	YGL097W|SRM1|S000003065|Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YMR266W	0.24715	YPR015C	YMR266W|RSN1|S000004879|Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YJL048C	0.236328	YPR015C	YJL048C|UBX6|S000003584|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YDL055C	0.235875	YPR015C	YDL055C|PSA1|S000002213|GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YBR177C	0.228057	YPR015C	YBR177C|EHT1|S000000381|Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YDR098C	0.222007	YPR015C	YDR098C|GRX3|S000002505|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YGR086C	0.219119	YPR015C	YGR086C|PIL1|S000003318|Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YAL022C	0.216657	YPR015C	YAL022C|FUN26|S000000020|Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YNL234W	0.214554	YPR015C	YNL234W||S000005178|Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YER107C	0.213049	YPR015C	YER107C|GLE2|S000000909|Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YIL118W	0.212302	YPR015C	YIL118W|RHO3|S000001380|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YER107W-A	0.210945	YPR015C	YER107W-A||S000028755|Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YCL024W	0.208593	YPR015C	YCL024W|KCC4|S000000529|Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YDR100W	0.207482	YPR015C	YDR100W|TVP15|S000002507|Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YGL009C	0.204795	YPR015C	YGL009C|LEU1|S000002977|Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YGL012W	0.20386	YPR015C	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YDR297W	0.203665	YPR015C	YDR297W|SUR2|S000002705|Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YDR185C	0.203313	YPR015C	YDR185C||S000002593|Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YGL201C	0.20106	YPR015C	YGL201C|MCM6|S000003169|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YOL124C	0.200719	YPR015C	YOL124C|TRM11|S000005484|Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YMR265C	0.193345	YPR015C	YMR265C||S000004878|Putative protein of unknown function
YER137C	0.193162	YPR015C	YER137C||S000000939|Putative protein of unknown function
YLR400W	0.189743	YPR015C	YLR400W||S000004392|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR432W	0.188063	YPR015C	YLR432W|IMD3|S000004424|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YMR043W	0.186997	YPR015C	YMR043W|MCM1|S000004646|Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YMR202W	0.186668	YPR015C	YMR202W|ERG2|S000004815|C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YCL023C	0.185811	YPR015C	YCL023C||S000000528|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YJL035C	0.185679	YPR015C	YJL035C|TAD2|S000003572|Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YLR154C	0.185416	YPR015C	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-C	0.184578	YPR015C	YLR154W-C|TAR1|S000028422|Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YMR320W	0.18394	YPR015C	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR055W	0.178704	YPR015C	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YKL051W	0.177813	YPR015C	YKL051W|SFK1|S000001534|Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YGR242W	0.171519	YPR015C	YGR242W||S000003474|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YKL052C	0.171476	YPR015C	YKL052C|ASK1|S000001535|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YHR183W	0.169565	YPR015C	YHR183W|GND1|S000001226|6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YOR099W	0.168524	YPR015C	YOR099W|KTR1|S000005625|Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YNL087W	0.168193	YPR015C	YNL087W|TCB2|S000005031|Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
YKL080W	0.166347	YPR015C	YKL080W|VMA5|S000001563|Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YPR156C	0.165525	YPR015C	YPR156C|TPO3|S000006360|Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YBR017C	0.164888	YPR015C	YBR017C|KAP104|S000000221|Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression
YER131W	0.164744	YPR015C	YER131W|RPS26B|S000000933|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YKL096W-A	0.160382	YPR015C	YKL096W-A|CWP2|S000001956|Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YPR074C	0.159867	YPR015C	YPR074C|TKL1|S000006278|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YHR181W	0.159862	YPR015C	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YOR047C	0.158746	YPR015C	YOR047C|STD1|S000005573|Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YER133W-A	0.158483	YPR015C	YER133W-A||S000028756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YEL068C	0.157041	YPR015C	YEL068C||S000000794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR043C	0.155527	YPR015C	YKR043C||S000001751|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YML077W	0.155469	YPR015C	YML077W|BET5|S000004542|Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
YPL172C	0.15396	YPR015C	YPL172C|COX10|S000006093|Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
YPL004C	0.151981	YPR015C	YPL004C|LSP1|S000005925|Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YER012W	0.14936	YPR015C	YER012W|PRE1|S000000814|Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YGR241C	0.144165	YPR015C	YGR241C|YAP1802|S000003473|Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YPR126C	0.142262	YPR015C	YPR126C||S000006330|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL012C	0.142083	YPR015C	YOL012C|HTZ1|S000005372|Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YFR056C	0.141472	YPR015C	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDL120W	0.13961	YPR015C	YDL120W|YFH1|S000002278|Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia
YPL256C	0.139164	YPR015C	YPL256C|CLN2|S000006177|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDR084C	0.137827	YPR015C	YDR084C|TVP23|S000002491|Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR173W	0.137429	YPR015C	YMR173W|DDR48|S000004784|DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
YBR210W	0.137213	YPR015C	YBR210W|ERV15|S000000414|Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YFL015C	0.137146	YPR015C	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGR249W	0.13713	YPR015C	YGR249W|MGA1|S000003481|Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YPL003W	0.134279	YPR015C	YPL003W|ULA1|S000005924|Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
YDL121C	0.133989	YPR015C	YDL121C||S000002279|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YLR229C	0.133931	YPR015C	YLR229C|CDC42|S000004219|Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YGR259C	0.133324	YPR015C	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YHR182C-A	0.131904	YPR015C	YHR182C-A||S000028784|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR173W-A	0.130583	YPR015C	YMR173W-A||S000004785|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W
YEL066W	0.130361	YPR015C	YEL066W|HPA3|S000000792|D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YLR029C	0.12993	YPR015C	YLR029C|RPL15A|S000004019|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YKL097C	0.129413	YPR015C	YKL097C||S000001580|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YLR333C	0.127786	YPR015C	YLR333C|RPS25B|S000004325|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YMR199W	0.127623	YPR015C	YMR199W|CLN1|S000004812|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGR036C	0.125939	YPR015C	YGR036C|CAX4|S000003268|Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YER134C	0.124978	YPR015C	YER134C||S000000936|Putative protein of unknown function; non-essential gene
YNL241C	0.124226	YPR015C	YNL241C|ZWF1|S000005185|Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YJL173C	0.123688	YPR015C	YJL173C|RFA3|S000003709|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YLR328W	0.123687	YPR015C	YLR328W|NMA1|S000004320|Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YER130C	0.121348	YPR015C	YER130C||S000000932|Hypothetical protein
YFL015W-A	0.120668	YPR015C	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR072C	0.119931	YPR015C	YDR072C|IPT1|S000002479|Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YKL218C	0.118486	YPR015C	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YFR042W	0.118393	YPR015C	YFR042W|KEG1|S000001938|Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
YPR017C	0.114758	YPR015C	YPR017C|DSS4|S000006221|Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YBR028C	0.113262	YPR015C	YBR028C||S000000232|Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
YPR118W	0.112848	YPR015C	YPR118W|MRI1|S000006322|Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
YEL058W	0.112307	YPR015C	YEL058W|PCM1|S000000784|Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YPL178W	0.11181	YPR015C	YPL178W|CBC2|S000006099|Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YOL011W	0.111788	YPR015C	YOL011W|PLB3|S000005371|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YGL022W	0.1101	YPR015C	YGL022W|STT3|S000002990|Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
YLR230W	0.109882	YPR015C	YLR230W||S000004220|Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
YNR016C	0.109358	YPR015C	YNR016C|ACC1|S000005299|Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YOR273C	0.108394	YPR015C	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YDR133C	0.107357	YPR015C	YDR133C||S000002540|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YDR348C	0.105141	YPR015C	YDR348C||S000002756|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate
YNR017W	0.105017	YPR015C	YNR017W|TIM23|S000005300|Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YGR040W	0.10449	YPR015C	YGR040W|KSS1|S000003272|Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YML054C-A	0.103421	YPR015C	YML054C-A||S000028573|Putative protein of unknown function
YDL171C	0.102046	YPR015C	YDL171C|GLT1|S000002330|NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YDR152W	0.101877	YPR015C	YDR152W|GIR2|S000002559|Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YGL209W	0.0999407	YPR015C	YGL209W|MIG2|S000003177|Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YOL101C	0.0987474	YPR015C	YOL101C|IZH4|S000005461|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YMR172C-A	0.0968685	YPR015C	YMR172C-A||S000004782|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR080W	0.0964626	YPR015C	YPR080W|TEF1|S000006284|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YBR247C	0.096393	YPR015C	YBR247C|ENP1|S000000451|Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YHR103W	0.0959638	YPR015C	YHR103W|SBE22|S000001145|Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
YOR013W	0.0958613	YPR015C	YOR013W|IRC11|S000005539|Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YNL169C	0.094604	YPR015C	YNL169C|PSD1|S000005113|Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YGL020C	0.0944107	YPR015C	YGL020C|GET1|S000002988|Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
YEL052W	0.0943529	YPR015C	YEL052W|AFG1|S000000778|Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YPL154C	0.0943189	YPR015C	YPL154C|PEP4|S000006075|Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
YDR023W	0.0929936	YPR015C	YDR023W|SES1|S000002430|Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YBR048W	0.0927696	YPR015C	YBR048W|RPS11B|S000000252|Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YJR123W	0.0926602	YPR015C	YJR123W|RPS5|S000003884|Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YBR178W	0.0925419	YPR015C	YBR178W||S000000382|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YNL178W	0.092523	YPR015C	YNL178W|RPS3|S000005122|Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YJR124C	0.0909699	YPR015C	YJR124C||S000003885|Putative protein of unknown function; expression induced under calcium shortage
YGR027C	0.0901043	YPR015C	YGR027C|RPS25A|S000003259|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YNR003C	0.0895343	YPR015C	YNR003C|RPC34|S000005286|RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YNL043C	0.0894509	YPR015C	YNL043C||S000004988|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YMR082C	0.0891868	YPR015C	YMR082C||S000004687|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL058W	0.0886465	YPR015C	YIL058W||S000001320|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL003C	0.0880645	YPR015C	YHL003C|LAG1|S000000995|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YOR155C	0.0865531	YPR015C	YOR155C|ISN1|S000005681|Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
YNL104C	0.0850884	YPR015C	YNL104C|LEU4|S000005048|Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YPR113W	0.084873	YPR015C	YPR113W|PIS1|S000006317|Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YDR073W	0.0837972	YPR015C	YDR073W|SNF11|S000002480|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YDR002W	0.0835948	YPR015C	YDR002W|YRB1|S000002409|Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YGL019W	0.0824849	YPR015C	YGL019W|CKB1|S000002987|Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
YEL059C-A	0.0823998	YPR015C	YEL059C-A|SOM1|S000002954|Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates
YLR120C	0.0816729	YPR015C	YLR120C|YPS1|S000004110|Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YLR353W	0.0814967	YPR015C	YLR353W|BUD8|S000004345|Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YDR531W	0.0806572	YPR015C	YDR531W||S000002939|Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YEL053C	0.0806511	YPR015C	YEL053C|MAK10|S000000779|Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YOL056W	0.0806122	YPR015C	YOL056W|GPM3|S000005417|Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YLR177W	0.0803491	YPR015C	YLR177W||S000004167|Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
YJR001W	0.0783965	YPR015C	YJR001W|AVT1|S000003761|Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YOR048C	0.0782056	YPR015C	YOR048C|RAT1|S000005574|Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YKL122C	0.0781936	YPR015C	YKL122C|SRP21|S000001605|Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YER147C-A	0.0776094	YPR015C	YER147C-A||S000028759|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL272C	0.0772498	YPR015C	YPL272C||S000006193|Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YLR411W	0.0770485	YPR015C	YLR411W|CTR3|S000004403|High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YNL289W	0.0770475	YPR015C	YNL289W|PCL1|S000005233|Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YBR032W	0.0770453	YPR015C	YBR032W||S000000236|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDL084W	0.0760131	YPR015C	YDL084W|SUB2|S000002242|Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YPL274W	0.0759714	YPR015C	YPL274W|SAM3|S000006195|High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YLR257W	0.075501	YPR015C	YLR257W||S000004247|Putative protein of unknown function
YKL110C	0.0735444	YPR015C	YKL110C|KTI12|S000001593|Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YKR013W	0.0725495	YPR015C	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YDL211C	0.0722124	YPR015C	YDL211C||S000002370|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YGR265W	0.0705293	YPR015C	YGR265W||S000003497|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YFR041C	0.0704901	YPR015C	YFR041C|ERJ5|S000001937|Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
YDR237W	0.0704131	YPR015C	YDR237W|MRPL7|S000002645|Mitochondrial ribosomal protein of the large subunit
YPR170W-B	0.06964	YPR015C	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YMR009W	0.069339	YPR015C	YMR009W|ADI1|S000004611|Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YMR208W	0.0673517	YPR015C	YMR208W|ERG12|S000004821|Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YCR028C-A	0.066932	YPR015C	YCR028C-A|RIM1|S000007222|Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
YDR375C	0.0666824	YPR015C	YDR375C|BCS1|S000002783|Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family
YMR011W	0.0661591	YPR015C	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGR177C	0.065786	YPR015C	YGR177C|ATF2|S000003409|Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YHR180W-A	0.0655667	YPR015C	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YLL027W	0.0648944	YPR015C	YLL027W|ISA1|S000003950|Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YML006C	0.0644876	YPR015C	YML006C|GIS4|S000004465|CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YLR002C	0.0639504	YPR015C	YLR002C|NOC3|S000003992|Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YAL007C	0.0625017	YPR015C	YAL007C|ERP2|S000000005|Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YFR035C	0.0616455	YPR015C	YFR035C||S000001931|Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
YDR261C	0.0612471	YPR015C	YDR261C|EXG2|S000002669|Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YOR043W	0.0611396	YPR015C	YOR043W|WHI2|S000005569|Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YNL173C	0.0599949	YPR015C	YNL173C|MDG1|S000005117|Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
YGR264C	0.0594646	YPR015C	YGR264C|MES1|S000003496|Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR108W	0.0591434	YPR015C	YGR108W|CLB1|S000003340|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YER136W	0.0590201	YPR015C	YER136W|GDI1|S000000938|GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YNR054C	0.0587495	YPR015C	YNR054C|ESF2|S000005337|Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YOL086C	0.0585949	YPR015C	YOL086C|ADH1|S000005446|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YKL043W	0.0584605	YPR015C	YKL043W|PHD1|S000001526|Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YHL017W	0.0582334	YPR015C	YHL017W||S000001009|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles
YLR420W	0.0581509	YPR015C	YLR420W|URA4|S000004412|Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YJR010W	0.0580632	YPR015C	YJR010W|MET3|S000003771|ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YBR023C	0.0576476	YPR015C	YBR023C|CHS3|S000000227|Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YPL234C	0.0575213	YPR015C	YPL234C|TFP3|S000006155|Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
YPR112C	0.0572337	YPR015C	YPR112C|MRD1|S000006316|Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains
YER148W	0.0569591	YPR015C	YER148W|SPT15|S000000950|TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YOL123W	0.056426	YPR015C	YOL123W|HRP1|S000005483|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YDL092W	0.0561389	YPR015C	YDL092W|SRP14|S000002250|Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YDL240W	0.0556502	YPR015C	YDL240W|LRG1|S000002399|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YPL250W-A	0.0555177	YPR015C	YPL250W-A||S000028589|Identified by fungal homology and RT-PCR
YKR057W	0.05548	YPR015C	YKR057W|RPS21A|S000001765|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein
YHL028W	0.0551786	YPR015C	YHL028W|WSC4|S000001020|ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YGR090W	0.0551779	YPR015C	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YMR319C	0.054512	YPR015C	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YDR209C	0.0541225	YPR015C	YDR209C||S000002617|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
YLR009W	0.0540164	YPR015C	YLR009W|RLP24|S000003999|Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YOR063W	0.0537376	YPR015C	YOR063W|RPL3|S000005589|Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YGR103W	0.0535821	YPR015C	YGR103W|NOP7|S000003335|Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation
YGR192C	0.0535294	YPR015C	YGR192C|TDH3|S000003424|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YPR119W	0.0528009	YPR015C	YPR119W|CLB2|S000006323|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YML094W	0.0512344	YPR015C	YML094W|GIM5|S000004559|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YOR342C	0.0511896	YPR015C	YOR342C||S000005869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YKR012C	0.0510109	YPR015C	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YGR178C	0.0509662	YPR015C	YGR178C|PBP1|S000003410|Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YNR008W	0.0490029	YPR015C	YNR008W|LRO1|S000005291|Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
YGL225W	0.0489763	YPR015C	YGL225W|VRG4|S000003193|Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YFL016C	0.0488526	YPR015C	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YJL198W	0.0488391	YPR015C	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YJL136C	0.0484787	YPR015C	YJL136C|RPS21B|S000003672|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YGL088W	0.0483211	YPR015C	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YHR144C	0.0480073	YPR015C	YHR144C|DCD1|S000001187|Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YDL160C-A	0.04794	YPR015C	YDL160C-A||S000028520|Putative protein of unknown function
YDR322W	0.0467459	YPR015C	YDR322W|MRPL35|S000002730|Mitochondrial ribosomal protein of the large subunit
YPR170C	0.0467164	YPR015C	YPR170C||S000006374|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YPR091C	0.0461944	YPR015C	YPR091C||S000006295|Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene
YAR030C	0.0455453	YPR015C	YAR030C||S000001821|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
YOR021C	0.0453589	YPR015C	YOR021C||S000005547|Putative protein of unknown function; YOR021C is not an essential gene
YER003C	0.0452095	YPR015C	YER003C|PMI40|S000000805|Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YLR008C	0.0451788	YPR015C	YLR008C|PAM18|S000003998|J-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p
YHL026C	0.0450248	YPR015C	YHL026C||S000001018|Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YPL137C	0.0449471	YPR015C	YPL137C|GIP3|S000006058|Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YNL288W	0.0443097	YPR015C	YNL288W|CAF40|S000005232|Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
YDL019C	0.0441077	YPR015C	YDL019C|OSH2|S000002177|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YAL023C	0.0438522	YPR015C	YAL023C|PMT2|S000000021|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YLR079W	0.043835	YPR015C	YLR079W|SIC1|S000004069|Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
YOL085C	0.0434471	YPR015C	YOL085C||S000005445|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YER005W	0.0425788	YPR015C	YER005W|YND1|S000000807|Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p
YIL011W	0.0424517	YPR015C	YIL011W|TIR3|S000001273|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YOL028C	0.0416704	YPR015C	YOL028C|YAP7|S000005388|Putative basic leucine zipper (bZIP) transcription factor
YKL068W-A	0.0415447	YPR015C	YKL068W-A||S000028524|Putative protein of unknown function; identified by homology to Ashbya gossypii
YML111W	0.041514	YPR015C	YML111W|BUL2|S000004579|Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YPR011C	0.0412143	YPR015C	YPR011C||S000006215|Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR130C	0.0412018	YPR015C	YOR130C|ORT1|S000005656|Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YDL006W	0.041196	YPR015C	YDL006W|PTC1|S000002164|Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
YIL056W	0.0411869	YPR015C	YIL056W|VHR1|S000001318|Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YMR049C	0.0410113	YPR015C	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YOR267C	0.0409277	YPR015C	YOR267C|HRK1|S000005793|Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YJR112W	0.0408026	YPR015C	YJR112W|NNF1|S000003873|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YMR037C	0.0407208	YPR015C	YMR037C|MSN2|S000004640|Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YPR074W-A	0.0406134	YPR015C	YPR074W-A||S000007631|Hypothetical protein identified by homology
YDL128W	0.0398571	YPR015C	YDL128W|VCX1|S000002286|Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YDR211W	0.0396992	YPR015C	YDR211W|GCD6|S000002619|Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YER043C	0.0396806	YPR015C	YER043C|SAH1|S000000845|S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YPL255W	0.0396504	YPR015C	YPL255W|BBP1|S000006176|Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YGL002W	0.0396485	YPR015C	YGL002W|ERP6|S000002970|Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR186W	0.0395818	YPR015C	YLR186W|EMG1|S000004176|Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers
YBL085W	0.0391821	YPR015C	YBL085W|BOI1|S000000181|Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YNL172W	0.0390983	YPR015C	YNL172W|APC1|S000005116|Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YMR229C	0.0390573	YPR015C	YMR229C|RRP5|S000004842|RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
YML005W	0.0388501	YPR015C	YML005W|TRM12|S000004464|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YGL050W	0.0383306	YPR015C	YGL050W|TYW3|S000003018|tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YOR239W	0.0376778	YPR015C	YOR239W|ABP140|S000005765|Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases
YGL206C	0.0372371	YPR015C	YGL206C|CHC1|S000003174|Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
YKL044W	0.0372289	YPR015C	YKL044W||S000001527|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL148W	0.0371972	YPR015C	YGL148W|ARO2|S000003116|Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YKL091C	0.0371943	YPR015C	YKL091C||S000001574|Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YJR009C	0.0368748	YPR015C	YJR009C|TDH2|S000003769|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YOR103C	0.0365652	YPR015C	YOR103C|OST2|S000005629|Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YFL014W	0.0364798	YPR015C	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YGL143C	0.0364481	YPR015C	YGL143C|MRF1|S000003111|Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
YKL160W	0.0363837	YPR015C	YKL160W|ELF1|S000001643|Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
YDR376W	0.0362959	YPR015C	YDR376W|ARH1|S000002784|Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
YBR085C-A	0.0361887	YPR015C	YBR085C-A||S000007522|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YMR112C	0.0361488	YPR015C	YMR112C|MED11|S000004718|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
YPL254W	0.0360426	YPR015C	YPL254W|HFI1|S000006175|Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
YAR071W	0.0360175	YPR015C	YAR071W|PHO11|S000000094|One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YPL090C	0.0358214	YPR015C	YPL090C|RPS6A|S000006011|Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YKL181W	0.0354972	YPR015C	YKL181W|PRS1|S000001664|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YPL144W	0.0354378	YPR015C	YPL144W|POC4|S000006065|Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YBL044W	0.0349269	YPR015C	YBL044W||S000000140|Putative protein of unknown function; YBL044W is not an essential protein
YKL136W	0.0348783	YPR015C	YKL136W||S000001619|Hypothetical protein
YGR266W	0.0342627	YPR015C	YGR266W||S000003498|Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YDR099W	0.0339464	YPR015C	YDR099W|BMH2|S000002506|14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YMR008C	0.0338278	YPR015C	YMR008C|PLB1|S000004610|Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YGR161W-C	0.0337956	YPR015C	YGR161W-C||S000029726|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YDR190C	0.0337556	YPR015C	YDR190C|RVB1|S000002598|Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YMR241W	0.033516	YPR015C	YMR241W|YHM2|S000004854|Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family
YFR001W	0.0330249	YPR015C	YFR001W|LOC1|S000001897|Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YEL067C	0.0329296	YPR015C	YEL067C||S000000793|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL155C	0.0325011	YPR015C	YOL155C|HPF1|S000005515|Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YBR130C	0.0324747	YPR015C	YBR130C|SHE3|S000000334|Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YML088W	0.0324468	YPR015C	YML088W|UFO1|S000004553|F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YKL216W	0.0322404	YPR015C	YKL216W|URA1|S000001699|Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YER068W	0.0322305	YPR015C	YER068W|MOT2|S000000870|Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
YBR181C	0.0316672	YPR015C	YBR181C|RPS6B|S000000385|Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YPR014C	0.0312283	YPR015C	YPR014C||S000006218|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YGR107W	0.0310011	YPR015C	YGR107W||S000003339|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER016W	0.0309343	YPR015C	YER016W|BIM1|S000000818|Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YGL003C	0.0307135	YPR015C	YGL003C|CDH1|S000002971|Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
YPL108W	0.0306354	YPR015C	YPL108W||S000006029|Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGR252W	0.0305266	YPR015C	YGR252W|GCN5|S000003484|Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
YIL049W	0.0304179	YPR015C	YIL049W|DFG10|S000001311|Protein of unknown function, involved in filamentous growth
YER006W	0.0302701	YPR015C	YER006W|NUG1|S000000808|GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
YIL061C	0.0300782	YPR015C	YIL061C|SNP1|S000001323|Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
YJL054W	0.0300208	YPR015C	YJL054W|TIM54|S000003590|Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane
YLL064C	0.0298288	YPR015C	YLL064C|PAU18|S000003987|Hypothetical protein
YJR111C	0.0297458	YPR015C	YJR111C||S000003872|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
YHL002W	0.0297139	YPR015C	YHL002W|HSE1|S000000994|Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YOR142W	0.0294798	YPR015C	YOR142W|LSC1|S000005668|Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
YKR003W	0.0293903	YPR015C	YKR003W|OSH6|S000001711|Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YHR005C-A	0.0293573	YPR015C	YHR005C-A|MRS11|S000003530|Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YPL136W	0.0283641	YPR015C	YPL136W||S000006057|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
YKL030W	0.0279916	YPR015C	YKL030W||S000001513|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
YNL134C	0.0279793	YPR015C	YNL134C||S000005078|Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YDL112W	0.0278789	YPR015C	YDL112W|TRM3|S000002270|2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YOL103W	0.0278549	YPR015C	YOL103W|ITR2|S000005463|Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YPL145C	0.0276843	YPR015C	YPL145C|KES1|S000006066|Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
YER006C-A	0.0276053	YPR015C	YER006C-A||S000028745|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2
YHR067W	0.0275514	YPR015C	YHR067W|HTD2|S000001109|Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
YNL235C	0.0273995	YPR015C	YNL235C||S000005179|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YLR224W	0.0273887	YPR015C	YLR224W||S000004214|F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YJL115W	0.027278	YPR015C	YJL115W|ASF1|S000003651|Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YLR335W	0.0272463	YPR015C	YLR335W|NUP2|S000004327|Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
YBL100C	0.026988	YPR015C	YBL100C||S000000196|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YJR118C	0.0268593	YPR015C	YJR118C|ILM1|S000003879|Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YHR180W	0.0265773	YPR015C	YHR180W||S000001223|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR002W	0.0263343	YPR015C	YAR002W|NUP60|S000000063|Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YBR112C	0.0262693	YPR015C	YBR112C|CYC8|S000000316|General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YOR354C	0.0262349	YPR015C	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL112W	0.0257462	YPR015C	YOL112W|MSB4|S000005472|GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
YJR040W	0.0255311	YPR015C	YJR040W|GEF1|S000003801|Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates
YGL204C	0.0255127	YPR015C	YGL204C||S000003172|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR292C	0.0250901	YPR015C	YLR292C|SEC72|S000004283|Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YGR251W	0.0248655	YPR015C	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YEL034C-A	0.024403	YPR015C	YEL034C-A||S000028743|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YIL169C	0.0239717	YPR015C	YIL169C||S000001431|Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YIL123W	0.0235711	YPR015C	YIL123W|SIM1|S000001385|Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YKL090W	0.0232881	YPR015C	YKL090W|CUE2|S000001573|Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YJL216C	0.0232132	YPR015C	YJL216C||S000003752|Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YOR098C	0.0228962	YPR015C	YOR098C|NUP1|S000005624|Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
YGR106C	0.0228677	YPR015C	YGR106C|VOA1|S000003338|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YGL051W	0.0225934	YPR015C	YGL051W|MST27|S000003019|Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
YGR253C	0.0224225	YPR015C	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YIL116W	0.0223016	YPR015C	YIL116W|HIS5|S000001378|Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YJR093C	0.0222864	YPR015C	YJR093C|FIP1|S000003853|Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity
YDL145C	0.0222611	YPR015C	YDL145C|COP1|S000002304|Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YHL029C	0.0222108	YPR015C	YHL029C|OCA5|S000001021|Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YPL279C	0.0215769	YPR015C	YPL279C||S000006200|Putative protein of unknown function
YDR187C	0.0215752	YPR015C	YDR187C||S000002595|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YGL162W	0.0214308	YPR015C	YGL162W|SUT1|S000003130|Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YMR135W-A	0.0212412	YPR015C	YMR135W-A||S000004743|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR036W	0.0212047	YPR015C	YFR036W|CDC26|S000001932|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YDR188W	0.0210563	YPR015C	YDR188W|CCT6|S000002596|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YBR125C	0.020964	YPR015C	YBR125C|PTC4|S000000329|Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
YMR102C	0.0208356	YPR015C	YMR102C||S000004708|Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YJR055W	0.0207522	YPR015C	YJR055W|HIT1|S000003816|Protein of unknown function, required for growth at high temperature
YJL193W	0.0203478	YPR015C	YJL193W||S000003729|Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YNL123W	0.0198809	YPR015C	YNL123W|NMA111|S000005067|Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YPR183W	0.0197802	YPR015C	YPR183W|DPM1|S000006387|Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
YJR020W	0.0197278	YPR015C	YJR020W||S000003781|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR032C	0.0197087	YPR015C	YDR032C|PST2|S000002439|Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL033W	0.0197026	YPR015C	YEL033W|MTC7|S000000759|Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YHL013C	0.0194142	YPR015C	YHL013C|OTU2|S000001005|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YHL002C-A	0.019387	YPR015C	YHL002C-A||S000028770|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER113C	0.0193518	YPR015C	YER113C|TMN3|S000000915|Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
YGL255W	0.0191462	YPR015C	YGL255W|ZRT1|S000003224|High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YDR459C	0.0190843	YPR015C	YDR459C|PFA5|S000002867|Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
YDL100C	0.0189774	YPR015C	YDL100C|GET3|S000002258|Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking; has low-level ATPase activity and is involved in resistance to heat and metal stress
YBR209W	0.0188664	YPR015C	YBR209W||S000000413|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YJL112W	0.0186021	YPR015C	YJL112W|MDV1|S000003648|Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YGL137W	0.0185674	YPR015C	YGL137W|SEC27|S000003105|Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YJL151C	0.018416	YPR015C	YJL151C|SNA3|S000003687|Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YLR253W	0.0181479	YPR015C	YLR253W||S000004243|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene
YIL029W-A	0.0181474	YPR015C	YIL029W-A||S000028788|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL078C	0.0178891	YPR015C	YDL078C|MDH3|S000002236|Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YLR078C	0.0177832	YPR015C	YLR078C|BOS1|S000004068|v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YOR104W	0.0177624	YPR015C	YOR104W|PIN2|S000005630|Protein that induces appearance of [PIN+] prion when overproduced
YKR036C	0.0175556	YPR015C	YKR036C|CAF4|S000001744|WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
YDR012W	0.0174927	YPR015C	YDR012W|RPL4B|S000002419|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YDL179W	0.0173573	YPR015C	YDL179W|PCL9|S000002338|Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
YPL257W	0.0172297	YPR015C	YPL257W||S000006178|Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YOR390W	0.0169578	YPR015C	YOR390W||S000005917|Putative protein of unknown function
YDR407C	0.0167863	YPR015C	YDR407C|TRS120|S000002815|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YAL038W	0.0166504	YPR015C	YAL038W|CDC19|S000000036|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YER048C	0.0166426	YPR015C	YER048C|CAJ1|S000000850|Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YPL244C	0.016261	YPR015C	YPL244C|HUT1|S000006165|Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
YML034C-A	0.0162595	YPR015C	YML034C-A||S000004499|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR105C	0.0161629	YPR015C	YLR105C|SEN2|S000004095|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YBL099W	0.016155	YPR015C	YBL099W|ATP1|S000000195|Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOR039W	0.0158034	YPR015C	YOR039W|CKB2|S000005565|Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
YDR418W	0.0158009	YPR015C	YDR418W|RPL12B|S000002826|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YLR412C-A	0.0156137	YPR015C	YLR412C-A||S000028572|Putative protein of unknown function
YLR302C	0.0155499	YPR015C	YLR302C||S000004293|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR031W	0.015506	YPR015C	YAR031W|PRM9|S000000078|Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
YIL076W	0.0153345	YPR015C	YIL076W|SEC28|S000001338|Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YNL186W	0.0151297	YPR015C	YNL186W|UBP10|S000005130|Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
YJL134W	0.0151106	YPR015C	YJL134W|LCB3|S000003670|Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids
YOL007C	0.015073	YPR015C	YOL007C|CSI2|S000005367|Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
YGR131W	0.0150625	YPR015C	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YER048W-A	0.0150038	YPR015C	YER048W-A|ISD11|S000007237|Protein required for mitochondrial iron-sulfur cluster biosynthesis
YBR044C	0.0149365	YPR015C	YBR044C|TCM62|S000000248|Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YCR024C	0.0147519	YPR015C	YCR024C|SLM5|S000000618|Mitochondrial asparaginyl-tRNA synthetase
YHR047C	0.0146074	YPR015C	YHR047C|AAP1|S000001089|Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YKR084C	0.0143574	YPR015C	YKR084C|HBS1|S000001792|GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components
YBR113W	0.0142514	YPR015C	YBR113W||S000000317|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YBR024W	0.0138063	YPR015C	YBR024W|SCO2|S000000228|Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YGR260W	0.0135644	YPR015C	YGR260W|TNA1|S000003492|High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YIL014W	0.0134159	YPR015C	YIL014W|MNT3|S000001276|Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
YMR198W	0.0133133	YPR015C	YMR198W|CIK1|S000004811|Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
YIL005W	0.0132359	YPR015C	YIL005W|EPS1|S000001267|ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
YML094C-A	0.0131158	YPR015C	YML094C-A||S000004561|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
YLL022C	0.0129124	YPR015C	YLL022C|HIF1|S000003945|Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing
YHR041C	0.0126041	YPR015C	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YDL095W	0.0124889	YPR015C	YDL095W|PMT1|S000002253|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals
YGR190C	0.0124836	YPR015C	YGR190C||S000003422|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YOR274W	0.0120667	YPR015C	YOR274W|MOD5|S000005800|Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YJL215C	0.012013	YPR015C	YJL215C||S000003751|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL026C	0.0119916	YPR015C	YAL026C|DRS2|S000000024|Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
YPL112C	0.0114559	YPR015C	YPL112C|PEX25|S000006033|Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YGR146C-A	0.0114508	YPR015C	YGR146C-A||S000028638|Putative protein of unknown function
YBL040C	0.0111537	YPR015C	YBL040C|ERD2|S000000136|HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YBR293W	0.0110624	YPR015C	YBR293W|VBA2|S000000497|Permease of basic amino acids in the vacuolar membrane
YOL161C	0.0108982	YPR015C	YOL161C|PAU20|S000005521|Hypothetical protein
YJL106W	0.0108725	YPR015C	YJL106W|IME2|S000003642|Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YJL200C	0.0107007	YPR015C	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YDL096C	0.010602	YPR015C	YDL096C|OPI6|S000002254|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
YCL026C-A	0.010562	YPR015C	YCL026C-A|FRM2|S000000589|Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases
YML035C	0.010459	YPR015C	YML035C|AMD1|S000004498|AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
YDR506C	0.0104089	YPR015C	YDR506C||S000002914|Possible membrane-localized protein
YJL107C	0.0103478	YPR015C	YJL107C||S000003643|Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YDR247W	0.0103004	YPR015C	YDR247W|VHS1|S000002655|Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YOR038C	0.0101778	YPR015C	YOR038C|HIR2|S000005564|Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
YBR161W	0.0101253	YPR015C	YBR161W|CSH1|S000000365|Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p
YDR331W	0.00988555	YPR015C	YDR331W|GPI8|S000002739|ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YPL126W	0.00976803	YPR015C	YPL126W|NAN1|S000006047|U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
YOR143C	0.00976453	YPR015C	YOR143C|THI80|S000005669|Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YML093W	0.00945686	YPR015C	YML093W|UTP14|S000004558|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPL243W	0.0094477	YPR015C	YPL243W|SRP68|S000006164|Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YEL050C	0.00929414	YPR015C	YEL050C|RML2|S000000776|Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YBR037C	0.0091902	YPR015C	YBR037C|SCO1|S000000241|Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YMR197C	0.00911287	YPR015C	YMR197C|VTI1|S000004810|Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
YKL055C	0.00906072	YPR015C	YKL055C|OAR1|S000001538|Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p
YDL122W	0.00898285	YPR015C	YDL122W|UBP1|S000002280|Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
YMR113W	0.0088574	YPR015C	YMR113W|FOL3|S000004719|Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
YPL189W	0.00871218	YPR015C	YPL189W|GUP2|S000006110|Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog
YNL280C	0.00870127	YPR015C	YNL280C|ERG24|S000005224|C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YMR016C	0.00858372	YPR015C	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YCR027C	0.00842754	YPR015C	YCR027C|RHB1|S000000622|Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
YJL072C	0.00839828	YPR015C	YJL072C|PSF2|S000003608|Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YKL032C	0.00839658	YPR015C	YKL032C|IXR1|S000001515|Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YJL140W	0.00808112	YPR015C	YJL140W|RPB4|S000003676|RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions
YPR123C	0.00795055	YPR015C	YPR123C||S000006327|Hypothetical protein
YER159C	0.00793111	YPR015C	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YGR191W	0.00784017	YPR015C	YGR191W|HIP1|S000003423|High-affinity histidine permease, also involved in the transport of manganese ions
YIL030C	0.00749438	YPR015C	YIL030C|SSM4|S000001292|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YBL086C	0.00729832	YPR015C	YBL086C||S000000182|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YPR124W	0.007254	YPR015C	YPR124W|CTR1|S000006328|High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
YDR052C	0.00676356	YPR015C	YDR052C|DBF4|S000002459|Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated
YIR020C	0.00674592	YPR015C	YIR020C||S000001459|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL032W	0.00674218	YPR015C	YEL032W|MCM3|S000000758|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YOR014W	0.00654861	YPR015C	YOR014W|RTS1|S000005540|B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
YJR148W	0.00634449	YPR015C	YJR148W|BAT2|S000003909|Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YER097W	0.00618815	YPR015C	YER097W||S000000899|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR188C	0.00595712	YPR015C	YGR188C|BUB1|S000003420|Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
YGR083C	0.00589686	YPR015C	YGR083C|GCD2|S000003315|Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YOR019W	0.00551834	YPR015C	YOR019W||S000005545|Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YJL199C	0.00547008	YPR015C	YJL199C|MBB1|S000003735|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YPL117C	0.00536776	YPR015C	YPL117C|IDI1|S000006038|Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
YNL068C	0.00535044	YPR015C	YNL068C|FKH2|S000005012|Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
YGR167W	0.00476117	YPR015C	YGR167W|CLC1|S000003399|Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
YER022W	0.00468516	YPR015C	YER022W|SRB4|S000000824|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YHR061C	0.00452123	YPR015C	YHR061C|GIC1|S000001103|Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
YER007W	0.00432177	YPR015C	YER007W|PAC2|S000000809|Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
YDR053W	0.00430646	YPR015C	YDR053W||S000002460|Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
YBL104C	0.00427469	YPR015C	YBL104C||S000000200|Putative protein of unknown function, promoter contains multiple GCN4 binding sites
YNL323W	0.00394373	YPR015C	YNL323W|LEM3|S000005267|Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YBR007C	0.00389373	YPR015C	YBR007C|DSF2|S000000211|Deletion suppressor of mpt5 mutation
YPR171W	0.00386715	YPR015C	YPR171W|BSP1|S000006375|Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YER053C	0.00384652	YPR015C	YER053C|PIC2|S000000855|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YBR038W	0.00357145	YPR015C	YBR038W|CHS2|S000000242|Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis
YMR029C	0.00356628	YPR015C	YMR029C|FAR8|S000004631|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YNR004W	0.00355437	YPR015C	YNR004W||S000005287|Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C
YEL017W	0.0035455	YPR015C	YEL017W|GTT3|S000000743|Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YML034W	0.00354031	YPR015C	YML034W|SRC1|S000004497|Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence
YDL030W	0.00337855	YPR015C	YDL030W|PRP9|S000002188|Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
YBR114W	0.00251032	YPR015C	YBR114W|RAD16|S000000318|Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YGL035C	0.00249173	YPR015C	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YLL021W	0.00247832	YPR015C	YLL021W|SPA2|S000003944|Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YPR024W	0.00214987	YPR015C	YPR024W|YME1|S000006228|Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YGR250C	0.00170219	YPR015C	YGR250C||S000003482|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR107C	0.00170033	YPR015C	YBR107C|IML3|S000000311|Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
YDL025C	0.0016527	YPR015C	YDL025C||S000002183|Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YPL233W	0.00155668	YPR015C	YPL233W|NSL1|S000006154|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YDL183C	0.00153081	YPR015C	YDL183C||S000002342|Putative protein of unknown function; YDL183C is not an essential gene
YLR006C	0.00152791	YPR015C	YLR006C|SSK1|S000003996|Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
YLR007W	0.00139962	YPR015C	YLR007W|NSE1|S000003997|Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes
YGR130C	0.00131924	YPR015C	YGR130C||S000003362|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YMR136W	0.00130515	YPR015C	YMR136W|GAT2|S000004744|Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YBR236C	0.00127091	YPR015C	YBR236C|ABD1|S000000440|Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YMR247C	0.00126296	YPR015C	YMR247C|RKR1|S000004861|Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene
YPR159W	0.00110147	YPR015C	YPR159W|KRE6|S000006363|Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p
YNL324W	0.000867918	YPR015C	YNL324W||S000005268|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR391C	0.000866746	YPR015C	YDR391C||S000002799|Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YNL040W	0.000830236	YPR015C	YNL040W||S000004985|Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene
YJR051W	0.000758133	YPR015C	YJR051W|OSM1|S000003812|Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity
YLR451W	0.00044442	YPR015C	YLR451W|LEU3|S000004443|Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis
YOR076C	0.000344327	YPR015C	YOR076C|SKI7|S000005602|Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs
YHR091C	0.000199921	YPR015C	YHR091C|MSR1|S000001133|Mitochondrial arginyl-tRNA synthetase
