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Results for AFT1

Z-value: 0.88

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Transcription factors associated with AFT1

Gene Symbol Gene ID Gene Info
AFT1
S000003039 Transcription factor involved in iron utilization and homeostasis

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AFT1YGL071W0.822.6e-07Click!

Activity profile of AFT1 motif

Sorted Z-values of AFT1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR383C 13.45
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR382W 13.17
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YDR536W 7.21
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YLR136C 5.99
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YEL065W 5.32
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YHL040C 5.31
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YLR205C 5.24
HMX1
ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YKL217W 4.79
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YAR053W 4.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER065C 3.84
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YDL210W 3.45
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YDR270W 3.28
CCC2
Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YLR327C 3.23
TMA10
Protein of unknown function that associates with ribosomes
YDR269C 3.19 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR151C 3.17
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YAR060C 3.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL057C 2.82 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YHR145C 2.70 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR087C 2.69
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YFR053C 2.65
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YAL062W 2.62
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YHR212C 2.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL049W 2.55
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YHR212W-A 2.37 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJR005C-A 2.19 Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene
YER084W 2.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR017W 2.12
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YGL146C 2.11 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YBR296C 2.10
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YER145C 2.03
FTR1
High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron
YCR021C 2.00
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YJL045W 1.92 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YER014C-A 1.90
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YNL237W 1.86
YTP1
Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
YOR208W 1.85
PTP2
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YOR384W 1.85
FRE5
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR056C 1.80
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YDL067C 1.79
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YHL035C 1.78
VMR1
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YBR292C 1.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YEL060C 1.76
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YKL031W 1.75 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YEL070W 1.75
DSF1
Deletion suppressor of mpt5 mutation
YFL051C 1.70 Putative protein of unknown function; YFL051C is not an essential gene
YLL029W 1.70
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YDR178W 1.70
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOR381W 1.69
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YGL072C 1.69 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YKR103W 1.66
NFT1
Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YKL038W 1.63
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YBL075C 1.63
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YOL158C 1.62
ENB1
Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
YBR047W 1.60
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL021W 1.58
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YDR231C 1.57
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YGL071W 1.56
AFT1
Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YLR326W 1.54 Hypothetical protein
YHL047C 1.52
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YJR152W 1.50
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YFL052W 1.50 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YHL046W-A 1.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR047C 1.48
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YFL063W 1.43 Dubious open reading frame, based on available experimental and comparative sequence data
YDR441C 1.41
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YOR186W 1.40 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YLR213C 1.40
CRR1
Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YPR007C 1.40
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YJL163C 1.39 Putative protein of unknown function
YOL084W 1.37
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YJL161W 1.35
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL102C 1.34 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YNL018C 1.33 Putative protein of unknown function
YBR046C 1.33
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YKL103C 1.33
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YGR065C 1.28
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YLR004C 1.28
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YLR334C 1.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YHR146W 1.24
CRP1
Protein that binds to cruciform DNA structures
YDR034C 1.21
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YLR174W 1.21
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YOR020W-A 1.18 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL011W 1.17
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YDR258C 1.16
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YLR267W 1.16
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YBR295W 1.16
PCA1
Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YOR139C 1.15 Hypothetical protein
YLR142W 1.14
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YDR342C 1.13
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YMR181C 1.12 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YLR356W 1.12 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YGR043C 1.12
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YHR211W 1.10
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YDR281C 1.09
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YFL064C 1.09 Putative protein of unknown function
YPR169W-A 1.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YIL146C 1.08
ECM37
Non-essential protein of unknown function
YDR379C-A 1.08 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YIL055C 1.07 Putative protein of unknown function
YFL021W 1.06
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YOR328W 1.06
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YMR271C 1.06
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YPR042C 1.06
PUF2
Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
YLR399C 1.06
BDF1
Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
YKR011C 1.04 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YER101C 1.04
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YOR084W 1.02
LPX1
Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
YHR205W 1.01
SCH9
Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB
YNR073C 1.01 Putative mannitol dehydrogenase
YGL089C 1.00
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YHR095W 1.00 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR406W 1.00
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YDL204W 0.99
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YJL133C-A 0.99 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR088W 0.99
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YOR140W 0.99
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YNL091W 0.99
NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YPL054W 0.98
LEE1
Zinc-finger protein of unknown function
YKL202W 0.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL057C 0.98
SUR1
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
YCL001W-A 0.98 Putative protein of unknown function; YCL001W-A is not an essential gene
YMR244W 0.97 Putative protein of unknown function
YOR186C-A 0.95 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR048W 0.95
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YOR388C 0.94
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YBL073W 0.94 Hypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors
YPR065W 0.94
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YCR005C 0.94
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YJR155W 0.93
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YBL100C 0.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YNL190W 0.93 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YPL111W 0.91
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YJL149W 0.91
DAS1
Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil
YER175C 0.90
TMT1
Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
YLR425W 0.89
TUS1
Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YMR175W-A 0.89 Putative protein of unknown function
YDR343C 0.88
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YDR171W 0.88
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YBL074C 0.87
AAR2
Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YEL030C-A 0.86 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR217C 0.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YML089C 0.85 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YLR403W 0.85
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YEL049W 0.85
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR442W 0.84 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR402W 0.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL013C 0.83
PDR11
ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth
YNR069C 0.83
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YIL144W 0.82
TID3
Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
YDL197C 0.82
ASF2
Anti-silencing protein that causes derepression of silent loci when overexpressed
YLR122C 0.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YAL063C 0.81
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YBR071W 0.80 Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress
YCR079W 0.80
PTC6
Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
YKL105C 0.80 Putative protein of unknown function
YPL061W 0.79
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YDR232W 0.79
HEM1
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YDL196W 0.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YDR528W 0.79
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YNL278W 0.79
CAF120
Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YMR081C 0.79
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YDR452W 0.78
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YPR013C 0.78 Putative zinc finger protein; YPR013C is not an essential gene
YKL046C 0.77
DCW1
Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
YMR141W-A 0.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C
YMR057C 0.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YDR077W 0.76
SED1
Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YGL136C 0.75
MRM2
Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
YEL030W 0.74
ECM10
Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
YBL060W 0.74
YEL1
Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip
YHR199C 0.73
AIM46
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YLR309C 0.73
IMH1
Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
YLR123C 0.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YDR380W 0.73
ARO10
Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YKR067W 0.72
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YBR284W 0.71 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YOR378W 0.71 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YDR169C 0.70
STB3
Protein that binds Sin3p in a two-hybrid assay
YHL005C 0.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W
YBR203W 0.70
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR132C 0.70
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YCL025C 0.69
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YDL113C 0.69
ATG20
Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YLR187W 0.69
SKG3
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p
YFL019C 0.68 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YBL099W 0.68
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YLL051C 0.68
FRE6
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YPR040W 0.67
TIP41
Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway
YOL025W 0.66
LAG2
Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells
YKR058W 0.66
GLG1
Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YOL060C 0.66
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YER004W 0.65
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR540C 0.65
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YHR097C 0.65 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YLL023C 0.65 Protein of unknown function; highly conserved across species and orthologous to human TMEM33; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the endoplasmic reticulum
YKR095W 0.64
MLP1
Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YHL041W 0.64 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR443C 0.63
SSN2
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
YOR020C 0.63
HSP10
Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YPL223C 0.63
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YOL085W-A 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C

Network of associatons between targets according to the STRING database.

First level regulatory network of AFT1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 38.7 GO:0015891 siderophore transport(GO:0015891)
1.6 1.6 GO:0015688 iron chelate transport(GO:0015688)
1.5 7.6 GO:0015793 glycerol transport(GO:0015793)
1.2 4.8 GO:0006848 pyruvate transport(GO:0006848)
1.0 4.0 GO:0046323 glucose import(GO:0046323)
0.9 3.7 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.9 2.6 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.7 6.3 GO:0006097 glyoxylate cycle(GO:0006097)
0.7 2.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.7 2.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.7 2.0 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.6 0.6 GO:0015755 fructose transport(GO:0015755)
0.6 1.7 GO:0043270 positive regulation of ion transport(GO:0043270)
0.5 2.2 GO:0015847 putrescine transport(GO:0015847)
0.5 2.1 GO:0000200 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.5 12.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.4 2.7 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.4 1.2 GO:0043335 protein unfolding(GO:0043335)
0.4 1.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.4 1.1 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.4 1.1 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.4 1.1 GO:0044209 AMP salvage(GO:0044209)
0.3 1.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.3 1.4 GO:0015886 heme transport(GO:0015886)
0.3 1.0 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 0.9 GO:0019627 urea metabolic process(GO:0019627)
0.3 3.3 GO:0015893 drug transport(GO:0015893)
0.3 0.3 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.3 0.8 GO:0034310 ethanol catabolic process(GO:0006068) acetate biosynthetic process(GO:0019413) primary alcohol catabolic process(GO:0034310)
0.3 0.8 GO:0015888 thiamine transport(GO:0015888)
0.3 1.3 GO:0051180 vitamin transport(GO:0051180)
0.3 0.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.2 0.7 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 1.0 GO:0043954 cellular component maintenance(GO:0043954)
0.2 1.2 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.2 0.5 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.2 0.9 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.2 1.3 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324) age-dependent general metabolic decline(GO:0007571)
0.2 2.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 1.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.4 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.2 1.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 1.0 GO:0045764 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 0.6 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.2 0.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.2 1.8 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.2 0.5 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.2 0.7 GO:0001666 response to hypoxia(GO:0001666)
0.2 1.1 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 2.3 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.2 1.2 GO:0010507 negative regulation of autophagy(GO:0010507)
0.2 0.2 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.2 0.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 0.7 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.2 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.6 GO:0072396 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.2 0.5 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.2 0.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.6 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.2 0.5 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.2 0.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 0.5 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.4 GO:0030656 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.1 0.4 GO:0001196 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.1 1.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 2.1 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.5 GO:0015809 arginine transport(GO:0015809)
0.1 0.6 GO:0006265 DNA topological change(GO:0006265)
0.1 3.8 GO:0022900 electron transport chain(GO:0022900)
0.1 0.4 GO:0046688 response to copper ion(GO:0046688)
0.1 0.6 GO:0009756 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 1.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 1.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.1 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.6 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 1.4 GO:0042026 protein refolding(GO:0042026)
0.1 1.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.4 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.4 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 0.2 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.1 0.6 GO:0016241 positive regulation of macroautophagy(GO:0016239) regulation of macroautophagy(GO:0016241)
0.1 0.4 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.4 GO:0015976 carbon utilization(GO:0015976)
0.1 1.0 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.2 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.6 GO:0015802 basic amino acid transport(GO:0015802)
0.1 1.2 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.3 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.3 GO:0070874 negative regulation of cellular carbohydrate metabolic process(GO:0010677) negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of carbohydrate metabolic process(GO:0045912) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.3 GO:0043200 response to amino acid(GO:0043200)
0.1 0.8 GO:0006813 potassium ion transport(GO:0006813)
0.1 0.2 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 0.4 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 1.7 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.4 GO:0043937 regulation of sporulation(GO:0043937)
0.1 0.3 GO:0009749 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.1 0.3 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.1 0.1 GO:0006739 NADP metabolic process(GO:0006739)
0.1 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 1.3 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.3 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.1 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.9 GO:0010648 negative regulation of signal transduction(GO:0009968) negative regulation of cell communication(GO:0010648) negative regulation of signaling(GO:0023057)
0.1 0.1 GO:0071469 response to alkaline pH(GO:0010446) cellular response to alkaline pH(GO:0071469)
0.1 0.3 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 0.2 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.1 GO:2001023 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.3 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.3 GO:0032443 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.1 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.6 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.4 GO:0000023 maltose metabolic process(GO:0000023)
0.1 1.7 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 0.4 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 2.0 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.2 GO:0042843 D-xylose catabolic process(GO:0042843)
0.1 1.4 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.7 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.2 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.1 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.1 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.0 0.1 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) mitotic G1/S transition checkpoint(GO:0044819)
0.0 0.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.3 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0006598 polyamine catabolic process(GO:0006598)
0.0 0.1 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.3 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.7 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.4 GO:0031990 NLS-bearing protein import into nucleus(GO:0006607) mRNA export from nucleus in response to heat stress(GO:0031990)
0.0 0.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.9 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.2 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.6 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.2 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.5 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 0.7 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.2 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.0 0.1 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.0 0.8 GO:0008361 regulation of cell size(GO:0008361)
0.0 0.2 GO:0070646 protein modification by small protein removal(GO:0070646)
0.0 0.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 1.0 GO:0000282 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.0 0.2 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.4 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0097271 protein localization to bud neck(GO:0097271)
0.0 0.3 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 1.2 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.2 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.0 0.1 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.2 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.1 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 0.1 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.0 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.1 GO:0048211 Golgi vesicle docking(GO:0048211)
0.0 0.3 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.2 GO:0009651 response to salt stress(GO:0009651)
0.0 0.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.3 GO:0007129 synapsis(GO:0007129)
0.0 0.4 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.0 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0016573 histone acetylation(GO:0016573)
0.0 0.3 GO:0030466 chromatin silencing at silent mating-type cassette(GO:0030466)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.2 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.7 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.0 0.0 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.0 0.0 GO:0031331 positive regulation of cellular catabolic process(GO:0031331)
0.0 0.2 GO:0048278 vesicle docking(GO:0048278)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.5 25.8 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.9 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.4 3.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.3 3.7 GO:0005619 ascospore wall(GO:0005619)
0.3 0.8 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 1.9 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.2 1.0 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 5.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.5 GO:0098797 plasma membrane protein complex(GO:0098797)
0.2 0.5 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.2 12.9 GO:0010008 endosome membrane(GO:0010008)
0.2 0.8 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.4 GO:0001400 mating projection base(GO:0001400)
0.1 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.5 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.3 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 0.3 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.1 0.3 GO:0035649 Nrd1 complex(GO:0035649)
0.1 2.3 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.5 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.1 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.8 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.1 GO:0070469 respiratory chain(GO:0070469)
0.1 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.1 1.1 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.3 GO:0070822 Sin3-type complex(GO:0070822)
0.1 8.6 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 1.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 0.5 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 1.5 GO:0005774 vacuolar membrane(GO:0005774)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.1 GO:0032126 eisosome(GO:0032126)
0.1 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.4 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 0.1 GO:0033263 CORVET complex(GO:0033263)
0.1 0.8 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0032545 CURI complex(GO:0032545)
0.0 0.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.0 2.0 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0033551 monopolin complex(GO:0033551)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.7 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0044697 HICS complex(GO:0044697)
0.0 11.6 GO:0005886 plasma membrane(GO:0005886)
0.0 0.1 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.6 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0005940 septin ring(GO:0005940)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 6.8 GO:0005740 mitochondrial envelope(GO:0005740)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.0 GO:0070390 nucleotide-excision repair factor 2 complex(GO:0000111) transcription export complex 2(GO:0070390)
0.0 0.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0005686 U2 snRNP(GO:0005686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 13.8 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
3.1 15.4 GO:0015295 solute:proton symporter activity(GO:0015295)
0.9 3.7 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.7 2.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.7 6.2 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.7 2.7 GO:0005537 mannose binding(GO:0005537)
0.6 2.3 GO:0004396 hexokinase activity(GO:0004396)
0.6 1.7 GO:0048038 quinone binding(GO:0048038)
0.5 3.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.5 2.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.5 1.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.4 4.7 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.4 1.5 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.4 1.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 1.4 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.3 0.9 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.3 0.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 1.1 GO:0008198 ferrous iron binding(GO:0008198)
0.3 1.6 GO:0051183 vitamin transporter activity(GO:0051183)
0.3 1.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 4.1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.2 1.1 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 0.6 GO:0005536 glucose binding(GO:0005536)
0.2 2.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 2.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.4 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 1.0 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 1.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.8 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.2 1.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.2 0.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 0.4 GO:0015294 solute:cation symporter activity(GO:0015294)
0.2 1.8 GO:0005216 ion channel activity(GO:0005216)
0.2 1.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.3 GO:0015293 symporter activity(GO:0015293)
0.1 0.6 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 2.0 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 1.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 7.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 0.5 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.3 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 2.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.4 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.1 0.2 GO:0005102 receptor binding(GO:0005102)
0.1 3.7 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 2.0 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.4 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.3 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.3 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.3 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 1.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 6.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.7 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 0.4 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 1.3 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.1 0.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.6 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.8 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.1 GO:0016208 AMP binding(GO:0016208)
0.1 0.3 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.2 GO:0097027 cyclin binding(GO:0030332) ubiquitin-protein transferase activator activity(GO:0097027)
0.1 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.2 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 1.7 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.2 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.7 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.5 GO:0060089 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.0 0.1 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.6 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.5 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.6 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.9 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0004713 protein serine/threonine/tyrosine kinase activity(GO:0004712) protein tyrosine kinase activity(GO:0004713)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.1 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.0 0.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.1 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.2 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.4 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.3 GO:0042393 histone binding(GO:0042393)
0.0 0.0 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 0.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.5 PID P73PATHWAY p73 transcription factor network
0.1 0.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 0.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 0.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 34.5 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.5 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 0.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 0.4 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.1 0.3 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 34.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules