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Results for ARO80

Z-value: 0.76

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Transcription factors associated with ARO80

Gene Symbol Gene ID Gene Info
ARO80
S000002829 Zinc-finger transcriptional activator of the Zn2Cys6 family

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARO80YDR421W-0.627.1e-04Click!

Activity profile of ARO80 motif

Sorted Z-values of ARO80 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 4.09
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 3.39 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDR098C 3.08
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPR157W 2.77 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YHR136C 2.73
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER131W 2.63
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YMR001C-A 2.59 Putative protein of unknown function
YDR033W 2.37
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGL055W 2.35
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YLR154C 2.34
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YGR251W 2.29 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YLR154W-B 2.25 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YER055C 2.19
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YKL216W 2.04
URA1
Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YLR154W-A 1.99 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGL039W 1.96 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YGL040C 1.96
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YDR509W 1.82 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR210W 1.79
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YDR508C 1.77
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YHR094C 1.59
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YLR348C 1.52
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YGL179C 1.52
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGR108W 1.48
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDR133C 1.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOR008C-A 1.47 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YLR349W 1.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YNR067C 1.45
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YDR345C 1.44
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR044W 1.41
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YJL011C 1.41
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YDL055C 1.39
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YER130C 1.38 Hypothetical protein
YMR032W 1.35
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YGL209W 1.35
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YAL038W 1.33
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YHR181W 1.32
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YIR021W 1.28
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YHR180W-A 1.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YER137C 1.23 Putative protein of unknown function
YOL154W 1.21
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YNL066W 1.20
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YNL079C 1.19
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YHR007C 1.14
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YOR095C 1.13
RKI1
Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YOR273C 1.12
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YJL158C 1.12
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YDR037W 1.10
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YPL263C 1.10
KEL3
Cytoplasmic protein of unknown function
YGL034C 1.09 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR123W 1.08
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YNL078W 1.07
NIS1
Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YHR137W 1.07
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YDR023W 1.07
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YBR032W 1.06 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR101C 1.06
ARX1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YHL015W 1.05
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YDR144C 1.04
MKC7
GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YKL218C 1.04
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YOR029W 1.04 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL001C 1.02
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YAR028W 1.01 Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YBL032W 1.01
HEK2
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YGR138C 1.00
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YBR009C 1.00
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YHL003C 1.00
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YMR290C 0.98
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YMR049C 0.98
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YOR107W 0.98
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YLR388W 0.96
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YEL066W 0.96
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YPR074C 0.96
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YMR246W 0.96
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YIL133C 0.94
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YGR264C 0.94
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YJL216C 0.94 Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YOR096W 0.94
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YLR154W-C 0.93
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YOR028C 0.93
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YER117W 0.92
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YNR016C 0.91
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YPR156C 0.90
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YMR290W-A 0.90 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YBR084W 0.89
MIS1
Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YDR095C 0.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL022C-A 0.88 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YDR535C 0.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YGR265W 0.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YNL028W 0.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL068C 0.86 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER146W 0.86
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YJL212C 0.86
OPT1
Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YPL014W 0.84 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YOL136C 0.83
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YLR314C 0.81
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YKR038C 0.81
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YOR269W 0.80
PAC1
Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
YHR201C 0.80
PPX1
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YDL047W 0.80
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YGL097W 0.79
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YPL090C 0.79
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YDR534C 0.79
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YFR054C 0.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR061W 0.78
RPL22A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YJR094W-A 0.78
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YOL103W 0.78
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YBR092C 0.76
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YBL039C 0.76
URA7
Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YDR021W 0.76
FAL1
Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YKL164C 0.76
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YER107W-A 0.75 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YHR092C 0.75
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YPL003W 0.74
ULA1
Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
YDR072C 0.74
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YEL054C 0.74
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YOR103C 0.74
OST2
Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YOL124C 0.74
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YNR018W 0.73
AIM38
Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YJR101W 0.73
RSM26
Mitochondrial ribosomal protein of the small subunit
YMR281W 0.73
GPI12
ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YOR004W 0.73
UTP23
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YDL236W 0.73
PHO13
Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
YKL110C 0.72
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YPL266W 0.71
DIM1
Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YNL160W 0.71
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YGL120C 0.70
PRP43
RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YCR022C 0.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YIL027C 0.67
KRE27
Protein of unknown function; null mutant shows K1 killer toxin resistance
YEL067C 0.67 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR226C 0.67
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YDR261C 0.66
EXG2
Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YPL250W-A 0.66 Identified by fungal homology and RT-PCR
YNL029C 0.65
KTR5
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YLR257W 0.65 Putative protein of unknown function
YBR143C 0.64
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YGR155W 0.64
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YER107C 0.64
GLE2
Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YGR118W 0.64
RPS23A
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YJR145C 0.63
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YML119W 0.63 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YDR046C 0.63
BAP3
Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YIL118W 0.63
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDR450W 0.62
RPS18A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YGL070C 0.62
RPB9
RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
YMR106C 0.62
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YGR242W 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YJR070C 0.62
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YEL051W 0.61
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YEL017W 0.61
GTT3
Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YDR047W 0.61
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YOR013W 0.60
IRC11
Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YFL022C 0.60
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YNL058C 0.60 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YPL004C 0.60
LSP1
Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YGL077C 0.60
HNM1
Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YJR071W 0.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR344C 0.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR110C 0.59
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YDL132W 0.59
CDC53
Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YMR177W 0.59
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YDR308C 0.59
SRB7
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
YOL155C 0.59
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YGR139W 0.59 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR094W 0.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YLR350W 0.58
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YDR531W 0.58 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YNL162W 0.57
RPL42A
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YJR001W 0.57
AVT1
Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YPL207W 0.56
TYW1
Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YKL040C 0.56
NFU1
Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
YKR079C 0.56
TRZ1
tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YOL079W 0.56 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR101W 0.56
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YCR072C 0.55
RSA4
WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YML123C 0.55
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YOL080C 0.55
REX4
Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YGL009C 0.54
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YML014W 0.54
TRM9
tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); deletion confers resistance to zymocin
YBR010W 0.54
HHT1
One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YPR148C 0.54 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR050C 0.53
TPI1
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YNL030W 0.53
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YMR099C 0.52 Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YGR181W 0.52
TIM13
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YKR074W 0.52
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGR280C 0.52
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YOL039W 0.52
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YGR266W 0.51 Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YGR241C 0.51
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YBR256C 0.51
RIB5
Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YEL013W 0.51
VAC8
Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
YGL158W 0.51
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YIL011W 0.50
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YKR075C 0.50 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGR052W 0.50
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOR108W 0.50
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YDR212W 0.50
TCP1
Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide
YDR399W 0.49
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YGL225W 0.49
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YLR420W 0.49
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate

Network of associatons between targets according to the STRING database.

First level regulatory network of ARO80

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.4 GO:0000296 spermine transport(GO:0000296)
0.8 2.4 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.8 2.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.6 3.9 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.5 1.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.5 1.9 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.5 1.4 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.4 2.5 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.4 1.2 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.4 2.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.4 0.8 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.4 0.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.3 3.3 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.3 1.0 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.3 1.0 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 5.3 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.3 0.6 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.3 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 1.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 0.8 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.2 1.7 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.2 1.6 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.2 1.6 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.2 0.6 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.2 1.1 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.2 1.0 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.2 1.0 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.2 2.5 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.2 0.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2 0.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.2 0.6 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.2 2.2 GO:0006817 phosphate ion transport(GO:0006817)
0.2 0.8 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.2 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.2 0.6 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.2 0.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.2 2.8 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 0.9 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 1.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.2 0.4 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.2 1.6 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 0.7 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.2 0.7 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.2 0.8 GO:0050667 homocysteine metabolic process(GO:0050667)
0.2 1.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.5 GO:0006567 threonine catabolic process(GO:0006567)
0.2 0.5 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.2 0.6 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.2 0.8 GO:0007535 donor selection(GO:0007535)
0.1 3.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 1.9 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 1.2 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.1 0.7 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 0.3 GO:0016093 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.1 4.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 4.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.8 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 0.8 GO:0045116 protein neddylation(GO:0045116)
0.1 0.4 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.4 GO:0055088 lipid homeostasis(GO:0055088)
0.1 0.9 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.6 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 0.5 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 1.8 GO:0030488 tRNA methylation(GO:0030488)
0.1 15.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.6 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.5 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.2 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.1 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.1 0.4 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.6 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 2.3 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.4 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 1.1 GO:0000921 septin ring assembly(GO:0000921)
0.1 0.4 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.1 2.5 GO:0006696 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.4 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 0.5 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.1 0.8 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.5 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.3 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.2 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.4 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 1.1 GO:0006415 translational termination(GO:0006415)
0.1 0.4 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 0.2 GO:0006687 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.3 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.3 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.3 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.1 0.3 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.2 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.1 2.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.2 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.1 0.9 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.6 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.1 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.1 0.5 GO:0015677 copper ion import(GO:0015677)
0.1 0.3 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.3 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.4 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0043097 UMP biosynthetic process(GO:0006222) pyrimidine nucleoside monophosphate metabolic process(GO:0009129) pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206) UMP metabolic process(GO:0046049)
0.1 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.1 1.7 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 1.6 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.2 GO:0030541 plasmid partitioning(GO:0030541)
0.1 0.3 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.1 2.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.1 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.1 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.1 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.4 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.6 GO:0000011 vacuole inheritance(GO:0000011)
0.1 0.1 GO:0032186 cellular bud neck septin ring organization(GO:0032186)
0.1 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 1.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.9 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 1.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 0.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.2 GO:0015883 FAD transport(GO:0015883)
0.1 0.4 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 1.0 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.2 GO:0043096 purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083)
0.1 0.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.2 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.1 0.5 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.1 0.3 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 0.5 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0 0.5 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 2.2 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.3 GO:0006901 vesicle coating(GO:0006901)
0.0 1.9 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.3 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.1 GO:0043966 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.0 3.7 GO:0006364 rRNA processing(GO:0006364)
0.0 0.2 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.0 0.1 GO:0006750 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.0 0.1 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 1.0 GO:0006506 GPI anchor biosynthetic process(GO:0006506) glycolipid biosynthetic process(GO:0009247)
0.0 0.6 GO:0007004 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.0 0.3 GO:0090151 establishment of protein localization to mitochondrial membrane(GO:0090151)
0.0 0.6 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.0 0.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.1 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.0 0.3 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.2 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.0 0.1 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.0 0.6 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.1 GO:0031058 positive regulation of histone modification(GO:0031058) positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.0 GO:0034517 ribophagy(GO:0034517)
0.0 0.2 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.1 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.2 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.0 0.1 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.1 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.1 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.0 0.3 GO:0071966 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.0 0.2 GO:0001301 progressive alteration of chromatin involved in cell aging(GO:0001301)
0.0 0.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.2 GO:0032973 amino acid export(GO:0032973)
0.0 0.1 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.0 0.2 GO:0031333 negative regulation of protein complex assembly(GO:0031333)
0.0 0.2 GO:0015858 nucleoside transport(GO:0015858)
0.0 0.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.6 GO:0051170 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.0 0.3 GO:0051668 localization within membrane(GO:0051668)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:0019243 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.3 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.0 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.6 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.3 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.0 0.1 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.0 0.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.0 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.1 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.0 GO:0044070 regulation of anion transport(GO:0044070)
0.0 0.2 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.1 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.3 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.2 GO:0006400 tRNA modification(GO:0006400)
0.0 0.0 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 1.6 GO:0030428 cell septum(GO:0030428)
0.4 1.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.4 1.1 GO:0070545 PeBoW complex(GO:0070545)
0.3 1.4 GO:0044697 HICS complex(GO:0044697)
0.2 13.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.8 GO:0032160 septin filament array(GO:0032160)
0.2 1.4 GO:0032432 actin filament bundle(GO:0032432)
0.2 2.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 0.6 GO:0034457 Mpp10 complex(GO:0034457)
0.2 0.7 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.2 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 0.5 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.2 0.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 0.7 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 10.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.4 GO:0035649 Nrd1 complex(GO:0035649)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.6 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.3 GO:0000928 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.1 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.9 GO:0005688 U6 snRNP(GO:0005688)
0.1 5.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.8 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.3 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.2 GO:0030869 RENT complex(GO:0030869)
0.1 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.5 GO:0034448 EGO complex(GO:0034448)
0.1 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.5 GO:0034456 UTP-C complex(GO:0034456)
0.1 0.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 1.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.4 GO:0030478 actin cap(GO:0030478)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 4.2 GO:0030686 90S preribosome(GO:0030686)
0.1 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.2 GO:0044284 mitochondrial crista junction(GO:0044284)
0.1 0.3 GO:0031518 CBF3 complex(GO:0031518)
0.1 1.9 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 0.3 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.1 0.3 GO:0042555 MCM complex(GO:0042555)
0.1 0.4 GO:0000346 transcription export complex(GO:0000346)
0.1 2.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 2.0 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.3 GO:0016592 mediator complex(GO:0016592)
0.1 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.2 GO:0000938 GARP complex(GO:0000938)
0.1 0.3 GO:0005871 kinesin complex(GO:0005871)
0.1 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.3 GO:0005869 dynactin complex(GO:0005869)
0.1 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.2 GO:0033176 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.1 1.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.2 GO:0032126 eisosome(GO:0032126)
0.0 0.5 GO:0005940 septin ring(GO:0005940)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.4 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0001400 mating projection base(GO:0001400)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.6 GO:0030118 clathrin coat(GO:0030118)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.1 GO:0043529 GET complex(GO:0043529)
0.0 0.5 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 4.7 GO:0005933 cellular bud(GO:0005933)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 2.9 GO:0005730 nucleolus(GO:0005730)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.3 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.5 GO:0005844 polysome(GO:0005844)
0.0 1.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119) AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.0 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.3 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0034044 exomer complex(GO:0034044)
0.0 0.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.3 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.0 GO:0000817 COMA complex(GO:0000817)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.9 3.4 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.8 2.4 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.6 2.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.6 2.4 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.5 3.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 1.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.4 1.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 1.4 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.3 1.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.3 1.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.3 0.9 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.3 3.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.3 0.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 0.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 0.8 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.3 1.3 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 0.7 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.2 0.7 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 0.7 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.2 0.7 GO:0008422 glucan exo-1,3-beta-glucosidase activity(GO:0004338) beta-glucosidase activity(GO:0008422)
0.2 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 1.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 0.8 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 0.6 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.2 0.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 0.5 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 0.5 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.2 0.7 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 1.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 1.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 2.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.4 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.9 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 1.0 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 0.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 1.8 GO:0051015 actin filament binding(GO:0051015)
0.1 1.2 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 1.3 GO:0005216 ion channel activity(GO:0005216)
0.1 2.0 GO:0015926 glucosidase activity(GO:0015926)
0.1 4.0 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.6 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 26.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.4 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 1.0 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.5 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.3 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 0.8 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.5 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 1.1 GO:0010181 FMN binding(GO:0010181)
0.1 0.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.5 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.5 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 0.3 GO:0001169 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.1 0.7 GO:0031386 protein tag(GO:0031386)
0.1 1.0 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 0.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 2.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 1.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.6 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.8 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.2 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 2.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.2 GO:0019003 GDP binding(GO:0019003)
0.1 0.3 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.2 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.2 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 1.8 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.1 GO:0015606 spermidine transmembrane transporter activity(GO:0015606)
0.1 0.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.4 GO:0015266 protein channel activity(GO:0015266)
0.1 0.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.1 0.1 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.1 0.3 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.2 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.7 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.0 0.9 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.9 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.3 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.4 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.8 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 1.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 1.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0031406 carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.0 0.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.1 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.0 1.6 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.1 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.0 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.2 GO:0019239 deaminase activity(GO:0019239)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity(GO:0008762)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.2 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.2 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters(GO:0016893)
0.0 0.1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.0 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0050661 NADP binding(GO:0050661)
0.0 0.2 GO:0008135 translation factor activity, RNA binding(GO:0008135)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 PID SHP2 PATHWAY SHP2 signaling
0.1 0.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.2 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.0 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 0.7 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.2 1.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 0.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 1.1 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.1 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.9 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
0.1 0.8 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.3 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 0.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.2 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.0 0.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.0 0.1 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase