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Results for SKN7

Z-value: 0.38

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Transcription factors associated with SKN7

Gene Symbol Gene ID Gene Info
SKN7
S000001249 Nuclear response regulator and transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SKN7YHR206W0.271.7e-01Click!

Activity profile of SKN7 motif

Sorted Z-values of SKN7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGL177W 0.90 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR053W 0.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL230W 0.49
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YGR087C 0.47
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YBR157C 0.47
ICS2
Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YOR186W 0.45 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YBR296C 0.44
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YBR292C 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YOL052C-A 0.40
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YLR164W 0.38 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR122C 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YGR051C 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YJR128W 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YIR038C 0.34
GTT1
ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
YPL026C 0.34
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YLR123C 0.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YGR236C 0.31
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR124W 0.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL179C 0.31 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YHR033W 0.31 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YHR048W 0.29
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YNL180C 0.28
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YGR039W 0.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YLR162W-A 0.25 Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YOR348C 0.25
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YKL165C-A 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR088W 0.23
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YGL035C 0.23
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YLR337C 0.22
VRP1
Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
YNL091W 0.22
NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YDR536W 0.22
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YJR120W 0.20 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YLR307W 0.20
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YNR002C 0.20
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YAR070C 0.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR154W-A 0.20 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YJR150C 0.20
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPR151C 0.19
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YBR291C 0.19
CTP1
Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YOR072W-A 0.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YPL024W 0.19
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YDR119W-A 0.18 Putative protein of unknown function
YOR032W-A 0.18 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YIL136W 0.17
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YOR072W 0.17 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YHR032W-A 0.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YIR019C 0.17
MUC1
GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
YGR259C 0.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YGR258C 0.16
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YAL062W 0.16
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YGL033W 0.16
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YIL099W 0.15
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YMR107W 0.14
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOR186C-A 0.14 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLL060C 0.14
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YGR260W 0.14
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YOR378W 0.14 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YPL261C 0.14 Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
YPR077C 0.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
YMR114C 0.13 Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
YPR030W 0.13
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YMR165C 0.13
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YEL049W 0.13
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YKR011C 0.13 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YIL101C 0.13
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YIL045W 0.13
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YOR344C 0.13
TYE7
Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YER062C 0.13
HOR2
One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YBR201C-A 0.12 Putative protein of unknown function
YOR345C 0.12 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YER116C 0.12
SLX8
Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YOR066W 0.12
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YDR014W-A 0.12
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YJL163C 0.12 Putative protein of unknown function
YBR105C 0.12
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YOR071C 0.12
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YIL100W 0.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YPL061W 0.12
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YDR259C 0.12
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YML089C 0.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YOR185C 0.11
GSP2
GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability
YOR032C 0.11
HMS1
Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YHR212W-A 0.11 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR211W 0.11
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YER020W 0.11
GPA2
Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YLL019C 0.11
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YDL139C 0.11
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YBR280C 0.11
SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YJR078W 0.11
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YLR154W-B 0.11 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGL163C 0.11
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YAR060C 0.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR083W 0.10
TEC1
Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YKL163W 0.10
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YBR222C 0.10
PCS60
Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YBR056W-A 0.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YDR466W 0.10
PKH3
Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YDL114W 0.10 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YMR213W 0.10
CEF1
Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
YMR206W 0.10 Putative protein of unknown function; YMR206W is not an essential gene
YIL164C 0.10
NIT1
Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YJR094C 0.10
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YFR016C 0.10 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YOR346W 0.10
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLL056C 0.10 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YPR065W 0.10
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YGR251W 0.10 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YFL021W 0.10
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YER054C 0.10
GIP2
Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YNL187W 0.10 Putative protein of unknown function; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; may interact with or be fuctionally redundant with Prp40p
YPR075C 0.10
OPY2
Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone
YDR313C 0.10
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YAR069C 0.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR115W 0.10 Putative protein of unknown function
YDL130W-A 0.10
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YLR312C 0.09
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YBR076C-A 0.09 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YLR296W 0.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR144W 0.09
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YPR036W-A 0.09 Protein of unknown function; transcription is regulated by Pdr1p
YOR192C 0.09
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YBL100C 0.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YJR160C 0.09
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YOL082W 0.09
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YJL133C-A 0.09 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL182W 0.09
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YKL166C 0.09
TPK3
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YGR180C 0.09
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YMR175W 0.09
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YBR269C 0.09
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR042C 0.09 Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YDR528W 0.09
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YMR090W 0.09 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YLR236C 0.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR054C 0.08
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YML047C 0.08
PRM6
Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
YML071C 0.08
COG8
Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YMR070W 0.08
MOT3
Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes
YBR190W 0.08 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
YNL161W 0.08
CBK1
Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation
YDR299W 0.08
BFR2
Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A
YMR320W 0.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL011W 0.08
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YDR155C 0.08
CPR1
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YDL138W 0.08
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YPR076W 0.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL014W 0.08
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YJR048W 0.08
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YER014C-A 0.08
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YOR229W 0.08
WTM2
Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats
YMR057C 0.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YJR104C 0.08
SOD1
Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YDR542W 0.08
PAU10
Hypothetical protein
YGR243W 0.08
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML082W 0.08 Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YER076W-A 0.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YIL100C-A 0.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL191W 0.07
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YER045C 0.07
ACA1
Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YLR193C 0.07
UPS1
Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI
YOL026C 0.07
MIM1
Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved
YLR125W 0.07 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YKL096W 0.07
CWP1
Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YFL014W 0.07
HSP12
Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YPL036W 0.07
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YOL156W 0.07
HXT11
Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
YPL265W 0.07
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YPL054W 0.07
LEE1
Zinc-finger protein of unknown function
YCR097W-A 0.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein
YMR172W 0.07
HOT1
Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
YKL109W 0.07
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YMR096W 0.07
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YER076C 0.07 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YEL071W 0.07
DLD3
D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
YLR380W 0.07
CSR1
Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YDR227W 0.07
SIR4
Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
YPR169W-A 0.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YMR135W-A 0.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL087C 0.07
LUC7
Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
YBR082C 0.07
UBC4
Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YCL069W 0.06
VBA3
Permease of basic amino acids in the vacuolar membrane
YML061C 0.06
PIF1
DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA
YMR172C-A 0.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL086W 0.06 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
YDR171W 0.06
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YPR096C 0.06 Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YGR294W 0.06
PAU12
Hypothetical protein
YGR009C 0.06
SEC9
t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
YEL045C 0.06 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YBR230C 0.06
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YOR055W 0.06 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YML090W 0.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YBR081C 0.06
SPT7
Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YAR050W 0.06
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YFR033C 0.06
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YPR013C 0.06 Putative zinc finger protein; YPR013C is not an essential gene
YLR007W 0.06
NSE1
Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes
YKL161C 0.06 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YDL011C 0.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YOL110W 0.06
SHR5
Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization

Network of associatons between targets according to the STRING database.

First level regulatory network of SKN7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.1 0.5 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.1 0.3 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.1 0.2 GO:0015888 thiamine transport(GO:0015888)
0.1 0.2 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.2 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.5 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.1 0.3 GO:0015793 glycerol transport(GO:0015793)
0.0 0.2 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.1 GO:0072353 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.0 0.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.0 0.3 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.0 0.1 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.2 GO:0046348 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.1 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.0 0.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.0 0.2 GO:0009251 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.4 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0 0.1 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.0 0.1 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.0 0.2 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.0 0.1 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.2 GO:0015893 drug transport(GO:0015893)
0.0 0.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.1 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.0 0.4 GO:0019740 nitrogen utilization(GO:0019740)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.0 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.1 GO:0015847 putrescine transport(GO:0015847)
0.0 0.2 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.0 0.1 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0008272 sulfate transport(GO:0008272)
0.0 0.0 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.0 0.3 GO:0006754 ATP biosynthetic process(GO:0006754)
0.0 0.1 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.0 0.1 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 0.2 GO:0009651 response to salt stress(GO:0009651)
0.0 0.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.0 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.2 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.1 GO:0046184 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.0 0.0 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.0 0.0 GO:0033866 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0 0.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.0 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.0 0.1 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.2 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 0.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.0 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.0 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.0 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.0 0.0 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.0 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0000133 polarisome(GO:0000133)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.0 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0034967 Set3 complex(GO:0034967)
0.0 0.0 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.0 0.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.5 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.3 GO:0005537 mannose binding(GO:0005537)
0.1 0.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.2 GO:0015295 solute:proton symporter activity(GO:0015295)
0.0 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.0 0.1 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0016208 AMP binding(GO:0016208)
0.0 0.0 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0005536 glucose binding(GO:0005536)
0.0 0.2 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.0 0.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.3 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0 0.1 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.0 0.1 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.0 0.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.0 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.0 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation