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Results for SUT2

Z-value: 0.52

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Transcription factors associated with SUT2

Gene Symbol Gene ID Gene Info
SUT2
S000006213 Putative transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SUT2YPR009W-0.526.6e-03Click!

Activity profile of SUT2 motif

Sorted Z-values of SUT2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGL258W-A 2.07 Putative protein of unknown function
YLR174W 1.96
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YJR095W 1.84
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YLR377C 1.84
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YER065C 1.68
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YFR053C 1.67
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YNR002C 1.50
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBR072W 1.36
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YER066W 1.33 Putative protein of unknown function; YER066W is not an essential gene
YOR049C 1.32
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YIR039C 1.27
YPS6
Putative GPI-anchored aspartic protease
YPL223C 1.23
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YFL030W 1.20
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YMR206W 1.16 Putative protein of unknown function; YMR206W is not an essential gene
YDL215C 1.07
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YBL015W 1.05
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YGL162W 1.04
SUT1
Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YLR356W 1.00 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YJL161W 0.96
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML042W 0.94
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YEL008W 0.93 Hypothetical protein predicted to be involved in metabolism
YMR272C 0.91
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YNL055C 0.90
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YNL160W 0.89
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YFL052W 0.89 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YJL116C 0.88
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YGL053W 0.86
PRM8
Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YOR120W 0.85
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YKR097W 0.84
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YJL045W 0.83 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YKL217W 0.81
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YJL166W 0.81
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YGR045C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR036C 0.79
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YDR277C 0.75
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDR343C 0.75
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YNL200C 0.74 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL125W 0.70
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YPL017C 0.70
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YMR210W 0.68 Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YMR008C 0.67
PLB1
Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YEL009C 0.66
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YHR211W 0.65
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YAR060C 0.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL200W 0.64
CSM4
Protein required for accurate chromosome segregation during meiosis
YGR288W 0.62
MAL13
MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YML100W 0.62
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YPL201C 0.62
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YKR040C 0.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YNL274C 0.60
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR031W 0.59
MIC14
Mitochondrial intermembrane space cysteine motif protein of 14 kDa
YPL014W 0.59 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YNL018C 0.59 Putative protein of unknown function
YJL127C-B 0.58 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YPR151C 0.58
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YKR102W 0.57
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YGR028W 0.57
MSP1
Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
YJL093C 0.56
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YPL222W 0.56
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR005C 0.56
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YFL024C 0.55
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YPR196W 0.55 Putative maltose activator
YDL015C 0.54
TSC13
Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
YKL223W 0.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL059W 0.54
GPD2
NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YDR216W 0.52
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YLR149C 0.52 Putative protein of unknown function; YLR149C is not an essential gene
YKL224C 0.52
PAU16
Putative protein of unknown function
YOL126C 0.51
MDH2
Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
YPL185W 0.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YHR212C 0.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL015C 0.49
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YNL237W 0.49
YTP1
Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
YLR295C 0.49
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJR048W 0.47
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YPL274W 0.46
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YGL055W 0.46
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YAR053W 0.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL001W 0.46
PHO80
Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
YGR088W 0.45
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YOL060C 0.45
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YHR212W-A 0.45 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOR343C 0.45 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR092C 0.44
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YHR210C 0.44 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YPL186C 0.43
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YML081C-A 0.43
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YGR043C 0.43
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YBL074C 0.42
AAR2
Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YKL004W 0.42
AUR1
Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
YLR296W 0.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL213W 0.41 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YGR087C 0.41
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YDR032C 0.41
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR023C 0.41
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YKL216W 0.40
URA1
Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YOL151W 0.39
GRE2
3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YMR110C 0.39
HFD1
Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
YBL073W 0.39 Hypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors
YPR030W 0.38
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YDR022C 0.38
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YLR350W 0.38
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YGR250C 0.38 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YFL051C 0.38 Putative protein of unknown function; YFL051C is not an essential gene
YMR107W 0.38
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR081C 0.37
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YOR378W 0.37 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YDR030C 0.37
RAD28
Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
YJL152W 0.36 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL171C 0.36
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YNR071C 0.36 Putative protein of unknown function
YOR152C 0.35 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YOR228C 0.35 Protein of unknown function, localized to the mitochondrial outer membrane
YHR139C-A 0.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR223C 0.35
TDP1
Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I
YJR151C 0.35
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YDL222C 0.34
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YIL102C 0.34 Putative protein of unknown function
YPR024W 0.34
YME1
Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YMR148W 0.33 Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene
YBR116C 0.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YHR139C 0.33
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOR387C 0.32 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YKL038W 0.32
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YPR007C 0.32
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YLR331C 0.31
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YML004C 0.31
GLO1
Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
YDL234C 0.30
GYP7
GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YOL084W 0.30
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YPR001W 0.30
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YJR020W 0.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL162W 0.30
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YHL024W 0.30
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YMR250W 0.30
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YIL120W 0.29
QDR1
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
YGR144W 0.29
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YMR082C 0.29 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL034W 0.29 Putative protein of unknown function; YNL034W is not an essential gene
YBL017C 0.29
PEP1
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YEL052W 0.29
AFG1
Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YBR203W 0.29
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR332W 0.29
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YOR317W 0.29
FAA1
Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YLR297W 0.29 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YNL202W 0.28
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YPR015C 0.28 Putative protein of unknown function
YCR007C 0.28 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YEL024W 0.28
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YHR140W 0.28 Putative integral membrane protein of unknown function
YPL271W 0.27
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOL106W 0.27 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YML058W-A 0.27
HUG1
Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage
YLR279W 0.27 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER033C 0.27
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YJL089W 0.27
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YPR006C 0.27
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YNL017C 0.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2
YLR366W 0.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YDL244W 0.26
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YJR019C 0.26
TES1
Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YIL014C-A 0.26 Putative protein of unknown function
YOL002C 0.25
IZH2
Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
YGL205W 0.25
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YJR078W 0.25
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YJL217W 0.25 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YGL033W 0.25
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YKR098C 0.25
UBP11
Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
YLL019C 0.25
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YCL021W-A 0.25 Putative protein of unknown function
YOR383C 0.24
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YEL012W 0.24
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YMR034C 0.24 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YCL001W-B 0.24 Putative protein of unknown function; identified by homology
YOL030W 0.24
GAS5
1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YJL130C 0.24
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YBR224W 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
YLL053C 0.24 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YDR058C 0.23
TGL2
Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear
YKL150W 0.23
MCR1
Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
YAL062W 0.23
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YML089C 0.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YLR135W 0.23
SLX4
Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YDL037C 0.23
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YJR077C 0.22
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YDR287W 0.22
INM2
Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YIR040C 0.22 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YLL052C 0.22
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YIR041W 0.22
PAU15
Hypothetical protein
YIL082W 0.22 Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
YMR170C 0.22
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YGR137W 0.21 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR204W 0.21
COQ4
Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
YDR234W 0.21
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YOR011W-A 0.21 Putative protein of unknown function
YGR213C 0.21
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YEL074W 0.21 Hypothetical protein
YDL130W-A 0.21
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YBR208C 0.21
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YGR067C 0.20 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YLL041C 0.20
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone

Network of associatons between targets according to the STRING database.

First level regulatory network of SUT2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.6 1.7 GO:0015755 fructose transport(GO:0015755)
0.5 2.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.5 4.8 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.4 1.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.3 0.9 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.3 0.8 GO:0042843 D-xylose catabolic process(GO:0042843)
0.3 1.3 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 1.6 GO:0015908 fatty acid transport(GO:0015908)
0.2 0.9 GO:2000911 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 0.6 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 0.8 GO:0006848 pyruvate transport(GO:0006848)
0.2 0.6 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.2 0.6 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 1.1 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.2 0.9 GO:0044070 regulation of anion transport(GO:0044070)
0.2 0.5 GO:0046321 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
0.2 0.5 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.7 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.2 0.5 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 1.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 0.6 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.2 0.3 GO:0046323 glucose import(GO:0046323)
0.2 0.5 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.2 1.1 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.3 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 2.2 GO:0015696 ammonium transport(GO:0015696)
0.1 1.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.3 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.1 0.4 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 2.0 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.1 0.4 GO:0019627 urea metabolic process(GO:0019627)
0.1 0.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.6 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.3 GO:0051596 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.1 0.4 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.1 1.1 GO:0016241 regulation of macroautophagy(GO:0016241)
0.1 1.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.2 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.4 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.1 0.3 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 0.7 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.4 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.2 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.8 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.2 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.1 0.3 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 0.4 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.9 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.1 0.2 GO:0000101 sulfur amino acid transport(GO:0000101)
0.1 0.2 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.3 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.3 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.1 0.2 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.1 0.4 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.2 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.1 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.1 0.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 1.3 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.2 GO:0046058 cAMP metabolic process(GO:0046058)
0.1 0.2 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0015888 thiamine transport(GO:0015888)
0.0 0.1 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.0 0.1 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.2 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.3 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.4 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.4 GO:0015891 siderophore transport(GO:0015891)
0.0 0.1 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.0 0.3 GO:0042773 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.0 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 0.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.2 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.7 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.2 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.1 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.0 0.1 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.6 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.3 GO:1901661 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.1 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.0 0.2 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.0 0.1 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0051099 positive regulation of binding(GO:0051099)
0.0 0.1 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.1 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.2 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.0 GO:1902932 positive regulation of alcohol biosynthetic process(GO:1902932) positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.0 0.8 GO:0070726 cell wall assembly(GO:0070726)
0.0 0.1 GO:0035384 acetyl-CoA biosynthetic process(GO:0006085) acetyl-CoA biosynthetic process from pyruvate(GO:0006086) thioester biosynthetic process(GO:0035384) acyl-CoA biosynthetic process(GO:0071616)
0.0 0.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.0 0.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0007129 synapsis(GO:0007129)
0.0 0.1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) ribonucleoside catabolic process(GO:0042454)
0.0 0.1 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.0 GO:1903138 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.0 0.7 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.2 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.1 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.0 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.1 GO:0060238 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.0 0.1 GO:0006826 iron ion transport(GO:0006826)
0.0 0.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0043954 cellular component maintenance(GO:0043954)
0.0 0.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.0 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.0 0.0 GO:0034033 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0 0.0 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.0 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0046930 pore complex(GO:0046930)
0.3 2.4 GO:0042597 periplasmic space(GO:0042597)
0.3 0.9 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.3 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.1 0.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.4 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.2 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.1 1.3 GO:0070469 respiratory chain(GO:0070469)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.8 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 1.7 GO:0005576 extracellular region(GO:0005576)
0.0 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 2.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0034657 GID complex(GO:0034657)
0.0 0.2 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.3 GO:0031160 spore wall(GO:0031160)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 14.0 GO:0005739 mitochondrion(GO:0005739)
0.0 0.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0031226 integral component of plasma membrane(GO:0005887) intrinsic component of plasma membrane(GO:0031226)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.0 GO:0032116 SMC loading complex(GO:0032116)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.7 2.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.5 1.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.4 1.8 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.9 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 1.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 1.3 GO:0005537 mannose binding(GO:0005537)
0.3 0.9 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.3 0.9 GO:0022829 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.3 0.9 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.3 1.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 0.5 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.2 0.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.0 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 0.8 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 0.8 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 0.6 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.2 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 0.5 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 1.2 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 1.9 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.3 GO:0022832 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.1 0.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 0.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.3 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.1 0.6 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.8 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.6 GO:0010181 FMN binding(GO:0010181)
0.1 0.2 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.1 0.2 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 1.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.4 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.4 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.7 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.1 0.3 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.2 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.7 GO:0051287 NAD binding(GO:0051287)
0.0 0.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.2 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.0 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.1 GO:0016208 AMP binding(GO:0016208)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.4 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0097027 cyclin binding(GO:0030332) ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.2 GO:0016298 lipase activity(GO:0016298)
0.0 0.4 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.0 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.0 0.2 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.1 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.0 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.0 0.1 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.0 0.3 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.1 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 0.1 GO:0015293 symporter activity(GO:0015293)
0.0 0.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 0.5 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.3 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein