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Results for UGA3

Z-value: 0.75

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Transcription factors associated with UGA3

Gene Symbol Gene ID Gene Info
UGA3
S000002329 Transcriptional activator for GABA-dependent induction of GABA genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UGA3YDL170W-0.801.2e-06Click!

Activity profile of UGA3 motif

Sorted Z-values of UGA3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 6.92
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YJR094W-A 6.77
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YLR154W-B 6.52 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-A 6.29 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YNR001W-A 6.21 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YFR056C 5.88 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YLR154C 5.73
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YKL218C 5.47
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YKR092C 5.21
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YDR033W 4.43
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YLR154W-C 4.03
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YOR101W 3.76
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YPL014W 3.72 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YDL047W 3.71
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YBR249C 3.63
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YDR508C 3.63
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YDR509W 3.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL055C 3.55
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YLR328W 3.50
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YJL153C 3.49
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YER131W 3.47
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YLL044W 3.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YGR108W 3.19
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YKL182W 3.18
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YMR290C 3.04
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDR044W 2.99
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YIL118W 2.97
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YFL015W-A 2.96 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR143C 2.95
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YMR290W-A 2.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YFL015C 2.92 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGR052W 2.90
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YIL056W 2.78
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YJL107C 2.75 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YER137C 2.71 Putative protein of unknown function
YGL103W 2.70
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YDR345C 2.65
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YMR102C 2.64 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YML043C 2.60
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YHR136C 2.51
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR002W 2.50
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YCL024W 2.40
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YPL250W-A 2.32 Identified by fungal homology and RT-PCR
YDL211C 2.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YKL063C 2.25 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YKR093W 2.25
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YAL003W 2.18
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YJL190C 2.17
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YBL063W 2.13
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YIR021W 2.13
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YMR281W 2.09
GPI12
ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YER177W 2.08
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YLR029C 2.05
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YDL048C 1.99
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YML075C 1.98
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YOL101C 1.97
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YHR216W 1.97
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YGR251W 1.96 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YGR157W 1.95
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YAL038W 1.94
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YKR075C 1.92 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGR050C 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL023C 1.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YGR123C 1.86
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YGR242W 1.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YGR018C 1.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W
YPR157W 1.79 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJL106W 1.79
IME2
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YDR095C 1.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER074W 1.78
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YGR124W 1.78
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YDR418W 1.78
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YOR153W 1.78
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YBR112C 1.77
CYC8
General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YGL179C 1.76
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YMR199W 1.75
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGR249W 1.75
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YGR241C 1.70
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YOL124C 1.70
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YNL178W 1.70
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YOR315W 1.68
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YJR105W 1.68
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YLR413W 1.67 Putative protein of unknown function; YLR413W is not an essential gene
YOR063W 1.63
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YGR280C 1.61
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YLR355C 1.59
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YEL056W 1.59
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YHR137W 1.58
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YJR114W 1.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YJR123W 1.56
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YER130C 1.55 Hypothetical protein
YOR108W 1.53
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YOL011W 1.49
PLB3
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YGR264C 1.47
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR051C 1.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YBR009C 1.46
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YMR208W 1.44
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YOL039W 1.44
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YHR013C 1.43
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YDR279W 1.41
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YJR113C 1.40
RSM7
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YLL045C 1.38
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YNR016C 1.38
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YLR110C 1.38
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YDR091C 1.37
RLI1
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YIL053W 1.36
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YLR437C 1.36 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YGR265W 1.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YGR214W 1.34
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YJL090C 1.33
DPB11
Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
YGL031C 1.32
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YKL051W 1.31
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YDR094W 1.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YGR138C 1.30
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YPR148C 1.30 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR158W 1.29
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YOL040C 1.27
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YGL209W 1.27
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YKL110C 1.27
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YLR183C 1.26
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YBR106W 1.26
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YLR048W 1.24
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YPL090C 1.23
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YOL012C 1.23
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YFR054C 1.22 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR185W 1.22
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YFL022C 1.22
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YPR052C 1.21
NHP6A
High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YNR054C 1.19
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YOL123W 1.18
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YKL068W-A 1.17 Putative protein of unknown function; identified by homology to Ashbya gossypii
YBR113W 1.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YGL030W 1.16
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YCR031C 1.16
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YHR021C 1.16
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YJR069C 1.15
HAM1
Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine
YDL023C 1.15 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YPL177C 1.14
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YDR385W 1.14
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YBL077W 1.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YDR060W 1.12
MAK21
Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YLR420W 1.12
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YGL225W 1.12
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YDR041W 1.11
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YMR296C 1.10
LCB1
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YKL096W-A 1.10
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YGR036C 1.09
CAX4
Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YHR128W 1.08
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YGL039W 1.08 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YHL028W 1.08
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YHR005C-A 1.07
MRS11
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YOL104C 1.06
NDJ1
Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes
YJL158C 1.06
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YDR510W 1.06
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YFL016C 1.05
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YBR159W 1.04
IFA38
Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YDR047W 1.02
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YJR009C 1.02
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YPR063C 1.01 ER-localized protein of unknown function
YMR132C 1.01
JLP2
Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YGL097W 1.00
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YOR025W 1.00
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YPR074C 1.00
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YER001W 0.99
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YOR309C 0.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YIR033W 0.98
MGA2
ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YPL121C 0.98
MEI5
Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
YMR246W 0.97
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YDL022W 0.97
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YML088W 0.96
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YDR257C 0.96
SET7
Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins
YDR156W 0.95
RPA14
RNA polymerase I subunit A14
YPL160W 0.95
CDC60
Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YIL052C 0.93
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YOL107W 0.93 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
YMR266W 0.92
RSN1
Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YJL011C 0.92
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YDR465C 0.91
RMT2
Arginine methyltransferase; ribosomal protein L12 is a substrate
YGL123C-A 0.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YOR273C 0.91
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YLR314C 0.90
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YGR086C 0.90
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YBL087C 0.89
RPL23A
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YPR029C 0.89
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YOR293W 0.89
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YGL123W 0.89
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YGL055W 0.89
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YGL201C 0.88
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBL085W 0.87
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YBR010W 0.87
HHT1
One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YBL028C 0.87 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YIL127C 0.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YBR104W 0.87
YMC2
Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YMR318C 0.85
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YKL062W 0.85
MSN4
Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YGR139W 0.85 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL154W 0.85
SRP102
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YPR146C 0.84 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR162W-A 0.84 Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YMR194C-A 0.84 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of UGA3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.3 4.0 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.3 5.1 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.2 3.7 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
1.1 7.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.0 2.9 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.9 8.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.9 3.7 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.9 3.4 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.8 2.5 GO:0030541 plasmid partitioning(GO:0030541)
0.8 2.4 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.8 3.1 GO:0000296 spermine transport(GO:0000296)
0.8 13.8 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.8 3.0 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.7 2.0 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.6 2.6 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.6 3.7 GO:0006021 inositol biosynthetic process(GO:0006021)
0.6 2.5 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.6 2.4 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.6 1.8 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.6 4.2 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.6 4.0 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.5 1.6 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.5 2.1 GO:0042938 dipeptide transport(GO:0042938)
0.5 0.5 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.5 0.9 GO:0070417 response to cold(GO:0009409) cellular response to cold(GO:0070417)
0.4 1.3 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.4 1.7 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.4 1.2 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.4 1.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.4 1.2 GO:0044209 AMP salvage(GO:0044209)
0.4 1.1 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.4 1.5 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.4 5.1 GO:0006415 translational termination(GO:0006415)
0.4 2.1 GO:0009099 valine biosynthetic process(GO:0009099)
0.4 0.4 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.3 4.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 0.9 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.3 1.2 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.3 1.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.3 2.0 GO:0043457 regulation of cellular respiration(GO:0043457)
0.3 35.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 0.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.3 1.6 GO:0070941 eisosome assembly(GO:0070941)
0.3 2.4 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.3 1.1 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.3 0.8 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.3 1.0 GO:0030497 fatty acid elongation(GO:0030497)
0.3 1.8 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.3 2.0 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.3 1.3 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 1.0 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.2 1.0 GO:0048313 Golgi inheritance(GO:0048313)
0.2 0.7 GO:0008272 sulfate transport(GO:0008272)
0.2 0.5 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.2 0.7 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.2 1.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.2 2.4 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 2.0 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.2 2.0 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.2 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.2 1.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 0.6 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.2 0.8 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.2 1.0 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.2 0.8 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.2 1.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2 4.8 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.2 1.1 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 2.0 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 0.6 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.2 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 0.5 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.2 0.4 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.2 1.6 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 1.3 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 0.7 GO:0006206 pyrimidine nucleobase metabolic process(GO:0006206)
0.2 0.5 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.2 0.4 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.2 2.3 GO:0006450 regulation of translational fidelity(GO:0006450)
0.2 1.9 GO:0000921 septin ring assembly(GO:0000921)
0.2 0.3 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.2 0.5 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.2 0.3 GO:0009302 snoRNA transcription(GO:0009302)
0.2 1.0 GO:0006491 N-glycan processing(GO:0006491)
0.2 2.8 GO:0030488 tRNA methylation(GO:0030488)
0.2 3.1 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.2 0.6 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.2 1.5 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.2 1.1 GO:0034063 stress granule assembly(GO:0034063)
0.2 1.2 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.1 0.3 GO:1902932 positive regulation of alcohol biosynthetic process(GO:1902932)
0.1 1.9 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.3 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.1 1.8 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.3 GO:0006567 threonine catabolic process(GO:0006567)
0.1 0.6 GO:0007535 donor selection(GO:0007535)
0.1 0.6 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.3 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.1 0.7 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 2.6 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 0.7 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 2.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.1 GO:0046417 chorismate metabolic process(GO:0046417)
0.1 0.4 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.5 GO:0015883 FAD transport(GO:0015883)
0.1 0.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.1 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.1 0.3 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.0 GO:0034398 telomere tethering at nuclear periphery(GO:0034398)
0.1 1.5 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.1 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 2.0 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 3.1 GO:0046939 nucleotide phosphorylation(GO:0046939)
0.1 0.5 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 1.0 GO:0051278 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.1 0.1 GO:0032231 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.4 GO:0006999 nuclear pore organization(GO:0006999)
0.1 0.8 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.3 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 0.6 GO:0042255 ribosome assembly(GO:0042255)
0.1 0.3 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.1 1.0 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.1 2.5 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.4 GO:0015793 glycerol transport(GO:0015793)
0.1 0.2 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.1 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 9.3 GO:0006913 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 0.7 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.8 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 2.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 0.4 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 1.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.4 GO:0046467 membrane lipid biosynthetic process(GO:0046467)
0.1 0.2 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.1 0.7 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.5 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.3 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 1.0 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.1 1.1 GO:0006414 translational elongation(GO:0006414)
0.1 1.6 GO:0006400 tRNA modification(GO:0006400)
0.1 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.6 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.5 GO:0006901 vesicle coating(GO:0006901)
0.1 0.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.1 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.5 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.1 0.5 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 1.1 GO:0009267 cellular response to starvation(GO:0009267)
0.1 0.3 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.1 0.3 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.2 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.1 0.9 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 2.0 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.1 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.1 1.5 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.1 0.2 GO:0045744 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032) negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.2 GO:0006057 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 1.5 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 0.3 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.1 0.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.2 GO:0000101 sulfur amino acid transport(GO:0000101)
0.1 1.8 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.5 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.8 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.2 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.4 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.0 0.6 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.0 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 4.8 GO:0006364 rRNA processing(GO:0006364)
0.0 0.6 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.0 0.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0051984 positive regulation of sister chromatid cohesion(GO:0045876) positive regulation of chromosome segregation(GO:0051984)
0.0 0.0 GO:0061647 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.0 0.1 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.1 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.1 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.0 GO:0035494 SNARE complex disassembly(GO:0035494) Golgi vesicle budding(GO:0048194) Golgi vesicle docking(GO:0048211)
0.0 0.2 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:0035269 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.2 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.0 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.3 GO:0015918 sterol transport(GO:0015918)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.6 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.4 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0016571 histone methylation(GO:0016571)
0.0 0.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.2 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.0 0.6 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.0 0.0 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.4 GO:0032259 methylation(GO:0032259)
0.0 1.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.0 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.0 0.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.1 GO:0046019 regulation of transcription by pheromones(GO:0009373) negative regulation of transcription by pheromones(GO:0045996) regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046019) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.0 GO:0097271 protein localization to bud neck(GO:0097271)
0.0 0.2 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.1 GO:0042401 amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.6 2.6 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.6 1.8 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.5 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.5 1.4 GO:0031415 NatA complex(GO:0031415)
0.4 2.5 GO:0005871 kinesin complex(GO:0005871)
0.4 2.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 1.2 GO:0032301 MutSalpha complex(GO:0032301)
0.4 33.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 24.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 1.8 GO:0030689 Noc complex(GO:0030689)
0.3 4.9 GO:0005940 septin ring(GO:0005940)
0.3 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 4.1 GO:0000786 nucleosome(GO:0000786)
0.3 0.9 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.3 1.7 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.3 0.3 GO:0000133 polarisome(GO:0000133)
0.3 1.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 1.6 GO:0042555 MCM complex(GO:0042555)
0.2 0.7 GO:0035649 Nrd1 complex(GO:0035649)
0.2 1.1 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.2 0.6 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 0.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 2.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.2 1.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.2 0.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 0.7 GO:0031518 CBF3 complex(GO:0031518)
0.2 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.7 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.2 1.2 GO:0032432 actin filament bundle(GO:0032432)
0.2 1.1 GO:0072686 mitotic spindle(GO:0072686)
0.2 1.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.2 0.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 5.4 GO:0005811 lipid particle(GO:0005811)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 2.0 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.5 GO:0000938 GARP complex(GO:0000938)
0.1 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.4 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 1.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.5 GO:0030118 clathrin coat(GO:0030118)
0.1 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.3 GO:0043529 GET complex(GO:0043529)
0.1 0.8 GO:0000346 transcription export complex(GO:0000346)
0.1 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.5 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.7 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.6 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 3.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 1.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.8 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.3 GO:0070823 HDA1 complex(GO:0070823)
0.1 0.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 13.8 GO:0005933 cellular bud(GO:0005933)
0.1 2.7 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 3.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.3 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.6 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 1.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.2 GO:0097255 R2TP complex(GO:0097255)
0.1 11.3 GO:0005730 nucleolus(GO:0005730)
0.1 1.1 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.1 0.6 GO:0000243 commitment complex(GO:0000243)
0.1 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.2 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.1 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.0 0.2 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.2 GO:0033176 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.4 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.1 GO:0034099 luminal surveillance complex(GO:0034099)
0.0 0.3 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.0 0.4 GO:0016586 RSC complex(GO:0016586)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.0 GO:0005880 nuclear microtubule(GO:0005880)
0.0 0.1 GO:0034044 exomer complex(GO:0034044)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.2 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.6 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 0.1 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.4 5.7 GO:0016841 ammonia-lyase activity(GO:0016841)
1.2 3.6 GO:0070568 guanylyltransferase activity(GO:0070568)
1.2 3.5 GO:0016872 intramolecular lyase activity(GO:0016872)
0.9 2.6 GO:0001169 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.8 2.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.8 4.8 GO:0016408 C-acyltransferase activity(GO:0016408)
0.8 2.4 GO:0072341 modified amino acid binding(GO:0072341)
0.8 3.1 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.7 3.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 2.9 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.7 4.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.7 2.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.6 1.9 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.5 1.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.5 2.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.5 1.4 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.4 1.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.4 1.7 GO:0019206 nucleoside kinase activity(GO:0019206)
0.4 1.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.4 1.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.4 4.0 GO:0005216 ion channel activity(GO:0005216)
0.4 2.4 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.4 1.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.4 1.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.3 1.6 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 0.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 3.1 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 2.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 59.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 4.0 GO:0070566 adenylyltransferase activity(GO:0070566)
0.3 0.3 GO:0019003 GDP binding(GO:0019003)
0.3 3.8 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.3 0.8 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.2 2.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 0.7 GO:0004100 chitin synthase activity(GO:0004100)
0.2 7.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 2.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.2 0.7 GO:0008251 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.2 0.7 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.2 0.9 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.2 2.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 6.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 1.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 1.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.2 1.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 0.8 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 1.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 0.2 GO:0015248 sterol transporter activity(GO:0015248)
0.2 1.0 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.6 GO:0019901 protein kinase binding(GO:0019901)
0.2 2.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 0.7 GO:0008252 nucleotidase activity(GO:0008252)
0.2 0.7 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.2 1.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.5 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.2 0.8 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 0.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.2 2.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.4 GO:0050661 NADP binding(GO:0050661)
0.1 0.7 GO:0008443 phosphofructokinase activity(GO:0008443)
0.1 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.1 8.8 GO:0003924 GTPase activity(GO:0003924)
0.1 0.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.5 GO:0008310 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.5 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.6 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 2.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 0.5 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.9 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 1.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.9 GO:0003724 RNA helicase activity(GO:0003724)
0.1 1.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 3.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.1 GO:0030276 clathrin binding(GO:0030276)
0.1 3.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 2.1 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 3.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 0.8 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.7 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.5 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.8 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.4 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 2.5 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.1 1.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.3 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.4 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.7 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 1.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.7 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 1.3 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 0.4 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 1.3 GO:0015926 glucosidase activity(GO:0015926)
0.1 1.3 GO:0005048 signal sequence binding(GO:0005048)
0.1 0.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 1.6 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.6 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.2 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.1 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.6 GO:0051015 actin filament binding(GO:0051015)
0.1 0.2 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.1 0.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.2 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.0 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 0.3 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 0.2 GO:0001167 RNA polymerase I transcription factor activity, sequence-specific DNA binding(GO:0001167)
0.0 1.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 1.0 GO:0003779 actin binding(GO:0003779)
0.0 0.2 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.0 0.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.3 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.0 GO:0016791 phosphatase activity(GO:0016791)
0.0 0.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0019900 MAP-kinase scaffold activity(GO:0005078) kinase binding(GO:0019900) signaling adaptor activity(GO:0035591)
0.0 0.3 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0001181 RNA polymerase I transcription factor binding(GO:0001179) transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 1.3 GO:0008289 lipid binding(GO:0008289)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.5 GO:0015631 tubulin binding(GO:0015631)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0016866 intramolecular transferase activity(GO:0016866)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.4 1.2 PID SHP2 PATHWAY SHP2 signaling
0.4 1.4 PID E2F PATHWAY E2F transcription factor network
0.3 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 0.7 PID FGF PATHWAY FGF signaling pathway
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.7 PID ATR PATHWAY ATR signaling pathway
0.0 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.4 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.6 9.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.4 1.2 REACTOME INSULIN RECEPTOR SIGNALLING CASCADE Genes involved in Insulin receptor signalling cascade
0.4 0.8 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.4 0.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 0.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 1.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.3 0.5 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.3 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 1.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 1.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 0.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.4 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 0.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.5 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.1 0.2 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.2 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.0 0.1 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME G1 S TRANSITION Genes involved in G1/S Transition