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Results for UME6

Z-value: 3.50

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Transcription factors associated with UME6

Gene Symbol Gene ID Gene Info
UME6
S000002615 Key transcriptional regulator of early meiotic genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UME6YDR207C0.582.1e-03Click!

Activity profile of UME6 motif

Sorted Z-values of UME6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJL089W 52.88
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YMR107W 47.80
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YKL217W 46.19
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YML042W 37.61
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YAL054C 31.21
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YML089C 28.21 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDL210W 23.19
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YJR095W 21.27
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YOR100C 20.80
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YCL025C 19.66
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YER111C 19.37
SWI4
DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YBL015W 18.99
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YDR059C 18.39
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YPL201C 18.37
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YML090W 18.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YKR097W 18.06
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YAR035W 17.92
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YHL024W 17.81
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YBL064C 16.03
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YPL171C 15.48
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YCR010C 15.34
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YDR014W-A 15.21
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YKL163W 15.19
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YML091C 15.02
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YPR001W 14.74
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YLR296W 14.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL016C 13.89
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YEL024W 13.65
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YNL305C 13.44 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YNL013C 13.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
YLR307C-A 13.24 Putative protein of unknown function
YIL057C 13.04 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPL017C 12.88
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YGL258W-A 12.70 Putative protein of unknown function
YOR387C 12.53 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YDR374C 12.40 Putative protein of unknown function
YGL062W 12.33
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YOL052C-A 12.32
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YGR043C 12.19
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YPR030W 11.93
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YOR382W 11.80
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR343C 11.70 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL269W 11.69
BSC4
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p
YFR053C 11.66
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YJL045W 11.52 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YLR295C 11.20
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YOR152C 11.19 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YPL240C 10.78
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YJL133C-A 10.62 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL038W 10.33
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YMR306W 10.32
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL200W 10.27
CSM4
Protein required for accurate chromosome segregation during meiosis
YJL152W 10.08 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL019C 9.72
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YFL052W 9.61 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YBR076C-A 9.59 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YOL131W 9.38 Putative protein of unknown function
YGL184C 9.06
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YJL103C 9.01
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YHL036W 8.97
MUP3
Low affinity methionine permease, similar to Mup1p
YDR018C 8.85 Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YJR128W 8.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YCR005C 8.72
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YIL144W 8.46
TID3
Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
YPL018W 8.46
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YPL147W 8.41
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YNL270C 8.35
ALP1
Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression
YMR280C 8.33
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YPR007C 8.26
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YBR250W 8.22
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YLR332W 8.22
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YMR040W 8.14
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YGL033W 8.12
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YJL163C 8.07 Putative protein of unknown function
YNR034W-A 8.06 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YDR092W 8.05
UBC13
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YLR331C 8.04
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YHR006W 7.95
STP2
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YOR338W 7.87 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YLL029W 7.87
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YBR284W 7.61 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YPL271W 7.57
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YNL144C 7.56 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDR055W 7.56
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YGL183C 7.49
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YLR259C 7.47
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YJR138W 7.38
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YLR438W 7.37
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YPR027C 7.31 Putative protein of unknown function
YFL063W 7.29 Dubious open reading frame, based on available experimental and comparative sequence data
YGR144W 7.26
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YGR067C 7.24 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YNL125C 7.15
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YJL116C 7.07
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YAL039C 7.04
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YIR039C 7.04
YPS6
Putative GPI-anchored aspartic protease
YJR091C 6.99
JSN1
Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
YAL018C 6.98 Putative protein of unknown function
YER053C 6.98
PIC2
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YOR378W 6.87 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YKR011C 6.85 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YGL180W 6.81
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YDR171W 6.69
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YOR178C 6.61
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YGR053C 6.57 Putative protein of unknown function
YLR297W 6.54 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR030W 6.52 Putative protein of unknown function
YDL215C 6.52
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YKL188C 6.49
PXA2
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YGL205W 6.47
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YKR009C 6.46
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YNL012W 6.41
SPO1
Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation
YGR087C 6.40
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YLR377C 6.38
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YPL058C 6.30
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YLR437C-A 6.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YHR079C-A 6.23
SAE3
Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
YJR137C 6.19
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YGR023W 6.19
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YJR120W 6.15 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YOR374W 6.13
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YGL138C 6.05 Putative protein of unknown function; has no significant sequence similarity to any known protein
YKL109W 6.03
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YDR542W 6.01
PAU10
Hypothetical protein
YFR026C 5.97 Putative protein of unknown function
YNL142W 5.94
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDR540C 5.92
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR351C 5.90
MEK1
Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
YOR020W-A 5.86 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL250W 5.80
RAD50
Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
YIL033C 5.76
BCY1
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YJL102W 5.71
MEF2
Mitochondrial elongation factor involved in translational elongation
YGR022C 5.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YDR273W 5.68
DON1
Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
YDL239C 5.68
ADY3
Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p
YJR038C 5.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL064C 5.62 Putative protein of unknown function
YGR268C 5.54
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YLR235C 5.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YGL104C 5.46
VPS73
Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YEL009C-A 5.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL057C-A 5.43 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL278C 5.40 Putative protein of unknown function; gene expression regulated by copper levels
YMR194C-B 5.40 Putative protein of unknown function
YDR359C 5.39
EAF1
Component of the NuA4 histone acetyltransferase complex; required for initiation of pre-meiotic DNA replication, probably due to its requirement for significant expression of IME1
YFL036W 5.36
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YGL250W 5.34
RMR1
Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
YDR360W 5.33
OPI7
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.
YPL181W 5.31
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YGL251C 5.30
HFM1
Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
YJR115W 5.24 Putative protein of unknown function
YPL222C-A 5.22 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLL030C 5.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR273C 5.16
PIG1
Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YOR177C 5.12
MPC54
Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
YDR186C 5.10 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YMR133W 5.05
REC114
Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
YAL005C 5.04
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YPL182C 5.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YGL096W 4.89
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YML066C 4.85
SMA2
Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YBR292C 4.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YPR145C-A 4.80 Putative protein of unknown function
YNL196C 4.76
SLZ1
Sporulation-specific protein with a leucine zipper motif
YPL152W 4.74
RRD2
Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex
YHR202W 4.68 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YFL024C 4.63
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YLR094C 4.61
GIS3
Protein of unknown function
YLL046C 4.58
RNP1
Ribonucleoprotein that contains two RNA recognition motifs (RRM)
YLL039C 4.54
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YDL182W 4.52
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YMR170C 4.52
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YIL125W 4.52
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YLR236C 4.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR020W 4.51
ATP20
Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YER116C 4.48
SLX8
Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YGR142W 4.48
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YOR290C 4.42
SNF2
Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YGR045C 4.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL143C 4.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL032C 4.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL092W 4.24 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
YLR356W 4.23 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YBR114W 4.22
RAD16
Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YAR053W 4.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR065W 4.20
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YMR101C 4.11
SRT1
Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
YPL161C 4.09
BEM4
Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length
YOL100W 4.08
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YLR237W 4.04
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YML058W 4.00
SML1
Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YBR295W 3.97
PCA1
Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YGR281W 3.93
YOR1
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
YLR122C 3.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YEL010W 3.85 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL111W 3.79
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YCL040W 3.78
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YDL194W 3.75
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YKR015C 3.71 Putative protein of unknown function
YFR027W 3.68
ECO1
Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair

Network of associatons between targets according to the STRING database.

First level regulatory network of UME6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.4 61.2 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
18.5 55.5 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
11.5 46.2 GO:0006848 pyruvate transport(GO:0006848)
8.2 57.3 GO:0006083 acetate metabolic process(GO:0006083)
7.1 21.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
6.4 25.8 GO:0046323 glucose import(GO:0046323)
6.0 18.0 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
6.0 23.9 GO:0015847 putrescine transport(GO:0015847)
5.5 16.5 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
5.3 15.9 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
4.2 21.1 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
3.8 11.3 GO:0070583 spore membrane bending pathway(GO:0070583)
3.7 3.7 GO:0015755 fructose transport(GO:0015755)
3.2 19.1 GO:0006279 premeiotic DNA replication(GO:0006279)
3.2 9.5 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
2.8 39.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
2.8 11.2 GO:0006527 arginine catabolic process(GO:0006527)
2.8 11.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.8 11.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
2.7 8.0 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
2.4 7.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
2.3 7.0 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
2.3 9.1 GO:0019346 transsulfuration(GO:0019346)
2.0 6.1 GO:0044109 cellular alcohol catabolic process(GO:0044109)
2.0 12.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
2.0 8.0 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
2.0 23.7 GO:0046686 response to cadmium ion(GO:0046686)
1.9 7.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.9 5.6 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
1.8 21.6 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
1.8 5.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
1.8 5.3 GO:0006311 meiotic gene conversion(GO:0006311)
1.7 15.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.7 8.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
1.6 8.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
1.6 12.8 GO:0015891 siderophore transport(GO:0015891)
1.5 1.5 GO:0000709 meiotic joint molecule formation(GO:0000709)
1.5 4.4 GO:0015888 thiamine transport(GO:0015888)
1.5 23.6 GO:0007129 synapsis(GO:0007129)
1.5 8.7 GO:0006097 glyoxylate cycle(GO:0006097)
1.4 1.4 GO:0006068 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
1.4 5.7 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
1.4 4.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.4 7.0 GO:0051654 establishment of mitochondrion localization(GO:0051654)
1.4 13.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.4 21.8 GO:0015718 monocarboxylic acid transport(GO:0015718)
1.3 2.6 GO:0031297 replication fork processing(GO:0031297)
1.3 15.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.2 2.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
1.2 20.5 GO:0000209 protein polyubiquitination(GO:0000209)
1.2 2.4 GO:0050685 positive regulation of mRNA processing(GO:0050685)
1.2 3.5 GO:0045596 negative regulation of cell differentiation(GO:0045596)
1.2 5.8 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
1.1 31.7 GO:0006094 gluconeogenesis(GO:0006094)
1.1 4.5 GO:0006598 polyamine catabolic process(GO:0006598)
1.1 27.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
1.1 11.7 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
1.1 9.5 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
1.0 8.2 GO:0034501 protein localization to kinetochore(GO:0034501)
1.0 6.1 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
1.0 8.0 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.9 12.1 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.9 9.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.9 4.4 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.9 0.9 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.9 4.3 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.9 2.6 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.8 2.5 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.8 3.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.8 4.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.8 1.6 GO:0046688 response to copper ion(GO:0046688)
0.8 3.2 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.8 2.3 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.8 17.7 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.8 4.6 GO:0006089 lactate metabolic process(GO:0006089)
0.7 0.7 GO:0009847 spore germination(GO:0009847)
0.7 1.4 GO:0000101 sulfur amino acid transport(GO:0000101) neutral amino acid transport(GO:0015804)
0.7 5.8 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.7 0.7 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of protein localization to nucleus(GO:1900182) positive regulation of cellular protein localization(GO:1903829) positive regulation of establishment of protein localization(GO:1904951)
0.7 9.0 GO:0006119 oxidative phosphorylation(GO:0006119)
0.7 5.3 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.6 3.9 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.6 1.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 2.4 GO:0030834 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.6 15.6 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.6 2.4 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.6 2.9 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.6 14.9 GO:0006312 mitotic recombination(GO:0006312)
0.6 3.4 GO:0043457 regulation of cellular respiration(GO:0043457)
0.6 11.4 GO:0015849 organic acid transport(GO:0015849)
0.6 2.2 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.6 5.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.5 2.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.5 2.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.5 7.1 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.5 4.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.4 6.3 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.4 16.6 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.4 2.7 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.4 1.3 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.4 2.2 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.4 2.1 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.4 3.9 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.4 1.3 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.4 1.3 GO:0019748 secondary metabolic process(GO:0019748)
0.4 1.7 GO:0009268 response to pH(GO:0009268)
0.4 2.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.4 2.0 GO:0016926 protein desumoylation(GO:0016926)
0.4 2.4 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.4 1.2 GO:0072479 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.4 0.8 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.4 2.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.4 3.4 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.4 2.3 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.4 2.6 GO:0019722 calcium-mediated signaling(GO:0019722)
0.4 1.1 GO:0016241 regulation of macroautophagy(GO:0016241)
0.4 1.8 GO:0042732 D-xylose metabolic process(GO:0042732)
0.4 2.9 GO:0019740 nitrogen utilization(GO:0019740)
0.4 1.4 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.4 3.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 3.5 GO:0006817 phosphate ion transport(GO:0006817)
0.3 1.0 GO:0005993 trehalose catabolic process(GO:0005993)
0.3 6.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.3 4.3 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.3 1.2 GO:0034389 lipid particle organization(GO:0034389)
0.3 4.0 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.2 0.2 GO:0031057 negative regulation of histone modification(GO:0031057)
0.2 1.2 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.2 0.4 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.2 3.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 0.7 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 1.3 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.2 0.4 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.2 1.7 GO:0006839 mitochondrial transport(GO:0006839)
0.2 0.5 GO:0015851 nucleobase transport(GO:0015851)
0.2 1.8 GO:0016925 protein sumoylation(GO:0016925)
0.2 1.5 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.2 0.6 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.2 11.7 GO:0031505 fungal-type cell wall organization(GO:0031505)
0.2 2.8 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 1.6 GO:0042026 protein refolding(GO:0042026)
0.2 0.9 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 3.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.1 3.5 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.1 0.8 GO:0015758 glucose transport(GO:0015758)
0.1 1.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 1.2 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 1.5 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 1.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.2 GO:0008105 asymmetric protein localization(GO:0008105)
0.1 1.1 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:0035690 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.5 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.3 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.4 GO:0055075 cellular potassium ion homeostasis(GO:0030007) regulation of ion transport(GO:0043269) potassium ion homeostasis(GO:0055075)
0.1 0.3 GO:0043937 regulation of sporulation(GO:0043937)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.2 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 0.3 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.2 GO:0015677 copper ion import(GO:0015677)
0.1 0.5 GO:0006826 iron ion transport(GO:0006826)
0.1 0.3 GO:0051569 positive regulation of histone methylation(GO:0031062) regulation of histone H3-K4 methylation(GO:0051569)
0.1 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.1 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.8 GO:0070646 protein modification by small protein removal(GO:0070646)
0.0 0.3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.0 8.3 GO:0007005 mitochondrion organization(GO:0007005)
0.0 0.1 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 1.0 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.8 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.3 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0001403 invasive growth in response to glucose limitation(GO:0001403)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 19.4 GO:0033309 SBF transcription complex(GO:0033309)
4.6 13.9 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
3.2 9.5 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
2.8 11.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
2.6 15.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
2.3 6.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
2.1 8.5 GO:0000817 COMA complex(GO:0000817)
1.9 5.8 GO:0030870 Mre11 complex(GO:0030870)
1.8 7.4 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
1.8 14.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.7 8.5 GO:0031262 Ndc80 complex(GO:0031262)
1.5 13.6 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.5 4.5 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
1.5 5.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.4 5.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.4 4.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
1.2 11.5 GO:0030677 ribonuclease P complex(GO:0030677)
1.1 76.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
1.1 3.3 GO:0032389 MutLalpha complex(GO:0032389)
1.0 5.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.9 1.9 GO:0001400 mating projection base(GO:0001400)
0.9 7.2 GO:0000795 synaptonemal complex(GO:0000795)
0.9 2.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.8 19.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.8 2.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.8 3.2 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.8 6.1 GO:0042597 periplasmic space(GO:0042597)
0.7 4.1 GO:0032126 eisosome(GO:0032126)
0.7 18.9 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.6 3.9 GO:0008180 COP9 signalosome(GO:0008180)
0.6 7.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.6 6.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.6 2.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.6 26.5 GO:0031225 anchored component of membrane(GO:0031225)
0.5 3.2 GO:0031499 TRAMP complex(GO:0031499)
0.5 4.5 GO:0005619 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.5 39.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.5 82.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 5.2 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.4 2.4 GO:0005884 polarisome(GO:0000133) actin filament(GO:0005884)
0.4 2.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.4 1.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.4 1.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.4 6.9 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.4 1.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 3.7 GO:0005769 early endosome(GO:0005769)
0.3 1.3 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.3 1.2 GO:0070469 respiratory chain(GO:0070469)
0.3 4.3 GO:0033698 Rpd3L complex(GO:0033698)
0.2 3.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.2 5.5 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.2 1.4 GO:0016272 prefoldin complex(GO:0016272)
0.2 2.6 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 1.7 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.2 1.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.2 2.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 1.3 GO:0005688 U6 snRNP(GO:0005688)
0.2 1.6 GO:0005685 U1 snRNP(GO:0005685)
0.2 1.4 GO:0000812 Swr1 complex(GO:0000812)
0.2 0.5 GO:0033186 CAF-1 complex(GO:0033186)
0.2 2.6 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.6 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 22.3 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 93.0 GO:0005739 mitochondrion(GO:0005739)
0.1 2.0 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.5 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 2.7 GO:0005770 late endosome(GO:0005770)
0.1 7.9 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.7 GO:0000793 condensed chromosome(GO:0000793)
0.1 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.4 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 0.2 GO:0000417 HIR complex(GO:0000417)
0.1 0.8 GO:0016586 RSC complex(GO:0016586)
0.1 0.4 GO:0097346 INO80-type complex(GO:0097346)
0.1 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:0097526 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
18.5 55.5 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
13.9 69.4 GO:0015295 solute:proton symporter activity(GO:0015295)
10.4 31.2 GO:0016208 AMP binding(GO:0016208)
7.8 23.5 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
7.2 21.5 GO:0016289 CoA hydrolase activity(GO:0016289)
5.3 21.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
3.9 15.4 GO:0004396 hexokinase activity(GO:0004396)
3.7 11.1 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
3.7 14.8 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
3.2 34.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
2.3 16.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
2.3 4.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
2.2 11.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
2.1 105.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.0 7.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.9 11.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.9 5.8 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
1.9 5.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
1.9 7.5 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
1.9 26.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
1.9 7.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.7 5.2 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
1.7 13.6 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.6 6.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.5 4.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.4 9.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.4 8.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.3 4.0 GO:0090482 vitamin transmembrane transporter activity(GO:0090482) azole transmembrane transporter activity(GO:1901474)
1.3 5.3 GO:0008198 ferrous iron binding(GO:0008198)
1.3 3.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.3 6.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.2 3.7 GO:0005536 glucose binding(GO:0005536)
1.2 1.2 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
1.2 6.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.2 12.4 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
1.2 11.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
1.2 9.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
1.2 15.6 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
1.2 17.4 GO:0016831 carboxy-lyase activity(GO:0016831)
1.2 11.5 GO:0004526 ribonuclease P activity(GO:0004526)
1.1 27.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
1.1 6.7 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
1.1 3.2 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825) trehalose-phosphatase activity(GO:0004805) carbohydrate phosphatase activity(GO:0019203)
0.9 4.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.9 3.8 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.9 7.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.9 2.7 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.9 3.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.9 10.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.9 2.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.9 1.8 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.9 2.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.9 1.7 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.8 2.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.8 2.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.8 2.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.8 8.8 GO:0004888 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.8 2.3 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.7 2.2 GO:0015294 solute:cation symporter activity(GO:0015294)
0.7 2.2 GO:0032452 histone demethylase activity(GO:0032452)
0.7 2.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 7.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.7 3.5 GO:0004707 MAP kinase activity(GO:0004707)
0.7 2.1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.7 2.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.7 2.0 GO:0032183 SUMO binding(GO:0032183)
0.6 5.7 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.6 4.5 GO:0000149 SNARE binding(GO:0000149)
0.6 5.6 GO:0035064 methylated histone binding(GO:0035064)
0.6 2.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.5 3.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.5 9.0 GO:0015297 antiporter activity(GO:0015297)
0.5 4.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 1.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.5 1.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.5 2.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.5 3.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.5 20.3 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.4 4.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.4 1.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 2.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.4 1.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.4 3.9 GO:0004620 phospholipase activity(GO:0004620)
0.3 1.0 GO:0030332 cyclin binding(GO:0030332)
0.3 2.4 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.3 1.0 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 2.6 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.3 1.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.3 1.3 GO:0005537 mannose binding(GO:0005537)
0.3 3.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 4.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.3 20.9 GO:0051082 unfolded protein binding(GO:0051082)
0.3 5.1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3 0.8 GO:0000150 recombinase activity(GO:0000150)
0.3 1.6 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.2 0.7 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.2 2.1 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 1.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 0.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.8 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.2 1.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.5 GO:0030246 carbohydrate binding(GO:0030246)
0.2 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.2 11.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 0.3 GO:0045118 azole transporter activity(GO:0045118)
0.2 1.3 GO:0015291 secondary active transmembrane transporter activity(GO:0015291)
0.2 2.9 GO:0008374 O-acyltransferase activity(GO:0008374)
0.2 3.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 1.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.2 1.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 3.1 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.1 3.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 0.9 GO:0010181 FMN binding(GO:0010181)
0.1 0.8 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 1.0 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 1.2 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035) disulfide oxidoreductase activity(GO:0015036)
0.1 0.5 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.1 1.0 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.9 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.4 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 0.4 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 0.2 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.6 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 4.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 3.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.4 GO:0060090 protein binding, bridging(GO:0030674) binding, bridging(GO:0060090)
0.0 0.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 18.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.9 5.8 PID ATM PATHWAY ATM pathway
0.9 5.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 407.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.2 0.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 0.4 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.0 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 26.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
2.8 8.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
2.2 6.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.5 10.4 REACTOME MEIOSIS Genes involved in Meiosis
0.6 1.9 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.4 1.5 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.3 407.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 0.7 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.2 1.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.1 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.4 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening