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Results for YPR013C

Z-value: 1.32

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Transcription factors associated with YPR013C

Gene Symbol Gene ID Gene Info
S000006217 Putative zinc finger protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YPR013C0.791.9e-06Click!

Activity profile of YPR013C motif

Sorted Z-values of YPR013C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKL163W 13.19
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YIL057C 7.23 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YAR053W 7.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR211W 6.80
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YOR348C 6.75
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YPL271W 6.74
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YER067C-A 6.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YFL051C 6.63 Putative protein of unknown function; YFL051C is not an essential gene
YKL093W 6.35
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YBL049W 6.20
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YMR107W 6.08
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YBR147W 5.82
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YLR312C 5.77
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YBR241C 5.75 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YCL025C 5.38
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YAR060C 5.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR296C 5.23
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YHR096C 5.14
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YBR230C 5.13
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YIL136W 4.90
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YPL223C 4.82
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YDR536W 4.81
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YGR087C 4.79
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YML128C 4.53
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YGR065C 4.49
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YJR146W 4.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YAL062W 4.39
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YFR022W 4.30
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YNL194C 4.25 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YML087C 4.17
AIM33
Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YJL116C 4.09
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YDR298C 4.09
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YEL059W 4.05 Dubious open reading frame unlikely to encode a functional protein
YDL210W 3.93
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YMR175W 3.93
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YDR530C 3.92
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YKL109W 3.87
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YDR379C-A 3.86 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YNL200C 3.86 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL070W 3.77
DSF1
Deletion suppressor of mpt5 mutation
YIL162W 3.74
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YFL058W 3.67
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YGR258C 3.66
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YDR540C 3.61
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YIL125W 3.59
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YHR212C 3.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR169C 3.46
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YGL255W 3.46
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YNR002C 3.38
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YML120C 3.30
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YNL036W 3.28
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YHR139C 3.27
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YPR127W 3.27 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YJL166W 3.25
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YHR212W-A 3.20 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR201C 3.12
RAD14
Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
YGR088W 3.06
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YJL037W 3.05
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YOR192C 3.05
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YPL156C 3.04
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YOL084W 3.03
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YOR066W 2.91
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YHR210C 2.90 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YBR117C 2.90
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YPL278C 2.90 Putative protein of unknown function; gene expression regulated by copper levels
YIL122W 2.83
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YLR296W 2.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL128W 2.80
VCX1
Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YCL048W-A 2.78 Putative protein of unknown function
YCR005C 2.77
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YOR208W 2.75
PTP2
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YOR192C-C 2.69 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YNR001C 2.69
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YOL051W 2.63
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YAL039C 2.63
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YDL113C 2.60
ATG20
Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YKL217W 2.58
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDR043C 2.57
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YNL052W 2.51
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YAL061W 2.46
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YLR295C 2.45
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YBR230W-A 2.36 Putative protein of unknown function
YHL040C 2.34
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YLR247C 2.32
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YPR192W 2.31
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YOR186W 2.29 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YKR102W 2.28
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YPL272C 2.27 Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YGL248W 2.25
PDE1
Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
YFR053C 2.22
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR148C 2.19
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YDL138W 2.19
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YGR191W 2.19
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YKL071W 2.18 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YMR013C 2.17
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YKL103C 2.17
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YMR219W 2.16
ESC1
Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p
YAL067C 2.15
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YJR078W 2.13
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YHR130C 2.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR178C 2.12
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YKR009C 2.09
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YMR253C 2.08 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YPR013C 2.06 Putative zinc finger protein; YPR013C is not an essential gene
YPL222W 2.05
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL274W 2.05
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YPL058C 2.04
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YFL055W 2.03
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YLL019C 2.02
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YBR116C 2.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YKL044W 2.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL038C 1.98
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YER014C-A 1.97
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YKL031W 1.95 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YGR190C 1.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YJL084C 1.93
ALY2
Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase
YOR211C 1.92
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YMR316C-B 1.92 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR269C 1.92
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR010C 1.90
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YDL181W 1.90
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YOR147W 1.89
MDM32
Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YLR047C 1.88
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YDR406W 1.88
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YLR136C 1.87
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YNL055C 1.82
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YBR037C 1.80
SCO1
Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YHR086W 1.79
NAM8
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YHR176W 1.79
FMO1
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YDL170W 1.79
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YNL037C 1.78
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YIL059C 1.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YDR070C 1.78
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR015C 1.77 Putative protein of unknown function
YNL180C 1.76
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YGR102C 1.74 Putative protein of unknown function; transposon insertion mutant is salt sensitive and deletion mutant has growth defects; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR346W 1.74
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YMR317W 1.72 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YLR252W 1.71 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YLL053C 1.69 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YJR147W 1.68
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YCR007C 1.68 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YJR020W 1.68 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL005C 1.65
MRP7
Mitochondrial ribosomal protein of the large subunit
YJR019C 1.65
TES1
Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YNL179C 1.64 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YKL102C 1.60 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YJL067W 1.59 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR345C 1.59 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YMR174C 1.57
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YGL139W 1.57
FLC3
Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YCL001W-B 1.56 Putative protein of unknown function; identified by homology
YDR022C 1.56
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YPL087W 1.54
YDC1
Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity
YNL283C 1.53
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YKL028W 1.53
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YJL005W 1.53
CYR1
Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YNL134C 1.51 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YDR542W 1.51
PAU10
Hypothetical protein
YFR026C 1.51 Putative protein of unknown function
YOR377W 1.50
ATF1
Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation
YDR380W 1.50
ARO10
Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YGL140C 1.49 Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YDL218W 1.49 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YDL127W 1.49
PCL2
G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth
YDR277C 1.49
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YNL063W 1.49
MTQ1
S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
YLL052C 1.48
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YHL025W 1.48
SNF6
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
YLR375W 1.48
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YPL113C 1.47 Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
YCL038C 1.47
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YDR251W 1.47
PAM1
Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YDR250C 1.46 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YPR065W 1.45
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YAR023C 1.45 Putative integral membrane protein, member of DUP240 gene family
YOL085W-A 1.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YLR374C 1.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YKL043W 1.43
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YMR135C 1.42
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YLR205C 1.41
HMX1
ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YDL109C 1.41 Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene
YLL056C 1.40 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YPL270W 1.40
MDL2
Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter
YBR047W 1.40
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL206C 1.39
PGC1
Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
YJL016W 1.39 Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
YBR169C 1.37
SSE2
Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YLR259C 1.36
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YKL112W 1.35
ABF1
DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YFL061W 1.35
DDI2
Protein whose expression is induced by DNA damage
YMR056C 1.33
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YDR151C 1.33
CTH1
Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
YDR470C 1.33
UGO1
Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion
YDL049C 1.32
KNH1
Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant
YML100W 1.32
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YBR033W 1.31
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YBR001C 1.31
NTH2
Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YLR297W 1.30 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR249C 1.30 Putative protein of unknown function

Network of associatons between targets according to the STRING database.

First level regulatory network of YPR013C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0015804 neutral amino acid transport(GO:0015804)
1.7 9.9 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.6 7.8 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.5 6.1 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.4 5.8 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.4 5.6 GO:0015847 putrescine transport(GO:0015847)
1.1 3.4 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.1 3.3 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.0 14.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.0 3.1 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
1.0 3.0 GO:0015888 thiamine transport(GO:0015888)
1.0 1.0 GO:0071361 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
1.0 4.8 GO:0015793 glycerol transport(GO:0015793)
0.9 1.9 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.9 2.6 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.9 3.5 GO:0006598 polyamine catabolic process(GO:0006598)
0.9 3.5 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.9 2.6 GO:1900460 biofilm formation(GO:0042710) negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.8 4.2 GO:0051180 vitamin transport(GO:0051180)
0.8 3.3 GO:0015976 carbon utilization(GO:0015976)
0.8 7.2 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.8 3.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.8 3.9 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.8 3.1 GO:0006848 pyruvate transport(GO:0006848)
0.8 3.8 GO:0046058 cAMP metabolic process(GO:0046058)
0.7 8.2 GO:0015758 glucose transport(GO:0015758)
0.7 2.2 GO:0045117 azole transport(GO:0045117)
0.7 5.7 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.7 6.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.7 2.8 GO:1903138 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.7 2.7 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.7 3.9 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.7 0.7 GO:0043419 urea catabolic process(GO:0043419)
0.7 3.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.6 0.6 GO:0019627 urea metabolic process(GO:0019627)
0.6 1.8 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.6 12.7 GO:0098656 anion transmembrane transport(GO:0098656)
0.6 3.0 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.6 1.8 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024) positive regulation of mRNA processing(GO:0050685)
0.5 1.6 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.5 1.5 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.5 3.6 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.5 1.5 GO:0005993 trehalose catabolic process(GO:0005993)
0.5 1.5 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 4.1 GO:0006829 zinc II ion transport(GO:0006829)
0.5 4.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 1.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 1.7 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.4 3.8 GO:0015696 ammonium transport(GO:0015696)
0.4 2.6 GO:0051182 coenzyme transport(GO:0051182)
0.4 1.3 GO:0072529 pyrimidine-containing compound catabolic process(GO:0072529)
0.4 1.6 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.4 6.5 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.4 3.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4 0.8 GO:0006013 mannose metabolic process(GO:0006013)
0.4 1.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.4 1.1 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.4 1.1 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.4 1.8 GO:0044070 regulation of anion transport(GO:0044070)
0.3 2.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.3 2.4 GO:0006828 manganese ion transport(GO:0006828)
0.3 2.1 GO:0051181 cofactor transport(GO:0051181)
0.3 4.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.3 2.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 1.0 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.3 0.9 GO:0043200 response to amino acid(GO:0043200)
0.3 0.9 GO:0000348 mRNA branch site recognition(GO:0000348)
0.3 4.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.3 2.3 GO:0015891 siderophore transport(GO:0015891)
0.3 1.2 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.3 0.9 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.3 1.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 1.1 GO:0030969 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.3 0.8 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.3 1.9 GO:0006119 oxidative phosphorylation(GO:0006119)
0.3 0.8 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.3 0.5 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.3 0.8 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 1.3 GO:0072348 sulfur compound transport(GO:0072348)
0.2 0.7 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.2 1.0 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.2 0.7 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.4 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 1.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 1.8 GO:0051274 (1->6)-beta-D-glucan biosynthetic process(GO:0006078) beta-glucan biosynthetic process(GO:0051274)
0.2 1.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 0.2 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 1.3 GO:0006020 inositol metabolic process(GO:0006020)
0.2 0.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 0.2 GO:2000906 starch metabolic process(GO:0005982) starch catabolic process(GO:0005983) regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter(GO:0035956) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0035957) regulation of starch catabolic process(GO:2000881) positive regulation of starch catabolic process(GO:2000883) regulation of starch metabolic process(GO:2000904) positive regulation of starch metabolic process(GO:2000906)
0.2 8.8 GO:0009060 aerobic respiration(GO:0009060)
0.2 0.2 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.2 2.5 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.2 1.1 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.2 0.7 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.2 0.5 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 0.4 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.2 1.6 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.5 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.2 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 7.7 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.2 0.8 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 0.5 GO:0043269 regulation of ion transport(GO:0043269)
0.2 1.0 GO:0030100 regulation of endocytosis(GO:0030100)
0.2 1.0 GO:0051260 protein homooligomerization(GO:0051260)
0.2 1.1 GO:0018345 protein palmitoylation(GO:0018345)
0.2 0.5 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.2 3.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 1.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 0.5 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.2 0.9 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.2 2.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 5.2 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.2 0.8 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.2 0.3 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.7 GO:0009209 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 2.1 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.8 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.1 3.7 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 1.6 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.1 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.1 1.2 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.1 0.3 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071) positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079) protein unfolding(GO:0043335)
0.1 0.8 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 1.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.2 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.6 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.3 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0019346 transsulfuration(GO:0019346)
0.1 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.1 0.4 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.9 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.8 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.5 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.5 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 1.0 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.3 GO:0042868 antisense RNA metabolic process(GO:0042868) antisense RNA transcript catabolic process(GO:0071041)
0.1 0.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.5 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 0.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.4 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 0.2 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.3 GO:0070941 eisosome assembly(GO:0070941)
0.1 1.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.0 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 0.2 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.1 0.2 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.1 2.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 0.3 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.4 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.2 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.1 0.3 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.1 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.1 0.6 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.1 0.2 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.0 0.3 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.1 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.9 GO:0022900 electron transport chain(GO:0022900)
0.0 0.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.0 0.0 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 0.5 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.6 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.2 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.2 GO:0050821 protein stabilization(GO:0050821)
0.0 0.8 GO:0048311 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.0 1.1 GO:0006479 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 0.3 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.0 0.2 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.2 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.0 0.2 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.1 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.0 0.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.2 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.9 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.3 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.5 GO:0032258 CVT pathway(GO:0032258)
0.0 0.2 GO:0007155 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.3 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.1 GO:0002252 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.2 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.2 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.0 0.1 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.4 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.1 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.2 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.1 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.0 0.4 GO:0072665 protein localization to vacuole(GO:0072665)
0.0 0.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0006415 translational termination(GO:0006415)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0015802 basic amino acid transport(GO:0015802)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0031166 integral component of vacuolar membrane(GO:0031166)
2.4 7.1 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.9 5.8 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
1.4 4.1 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
1.1 3.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
1.0 4.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.9 1.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.7 13.1 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.6 1.9 GO:0030061 mitochondrial crista(GO:0030061)
0.5 3.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.5 1.4 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.5 3.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.4 1.7 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.4 0.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 2.4 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.4 1.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.4 1.1 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.3 3.0 GO:0070069 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) cytochrome complex(GO:0070069)
0.3 0.9 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.3 1.4 GO:0031931 TORC1 complex(GO:0031931)
0.3 0.8 GO:0035649 Nrd1 complex(GO:0035649)
0.3 2.3 GO:0070469 respiratory chain(GO:0070469)
0.2 1.7 GO:0034657 GID complex(GO:0034657)
0.2 1.7 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 1.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.2 GO:0032221 Rpd3S complex(GO:0032221)
0.2 0.9 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 1.3 GO:0032126 eisosome(GO:0032126)
0.2 1.0 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.4 GO:0030478 actin cap(GO:0030478)
0.2 4.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.5 GO:0033186 CAF-1 complex(GO:0033186)
0.2 1.9 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 0.8 GO:0070772 PAS complex(GO:0070772)
0.2 7.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 3.2 GO:0016592 mediator complex(GO:0016592)
0.1 1.4 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.1 1.2 GO:0005769 early endosome(GO:0005769)
0.1 3.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.4 GO:0001400 mating projection base(GO:0001400)
0.1 0.9 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 2.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.5 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.1 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 13.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.1 GO:0097346 INO80-type complex(GO:0097346)
0.1 0.3 GO:0070985 TFIIK complex(GO:0070985)
0.1 3.2 GO:0005576 extracellular region(GO:0005576)
0.1 1.7 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.1 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.6 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 7.4 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 0.2 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.1 1.9 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.3 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 3.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 4.5 GO:0005774 vacuolar membrane(GO:0005774)
0.1 1.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 14.5 GO:0005886 plasma membrane(GO:0005886)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0034967 Set3 complex(GO:0034967)
0.0 1.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.9 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0005680 nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 17.3 GO:0005739 mitochondrion(GO:0005739)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.4 GO:0031160 spore wall(GO:0031160)
0.0 0.1 GO:0070390 transcription export complex 2(GO:0070390)
0.0 0.3 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) endoribonuclease complex(GO:1902555)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.9 GO:0005934 cellular bud tip(GO:0005934)
0.0 0.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 11.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
2.7 10.9 GO:0005537 mannose binding(GO:0005537)
2.3 11.3 GO:0015295 solute:proton symporter activity(GO:0015295)
1.8 5.5 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.5 4.6 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
1.5 6.1 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.3 14.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.2 3.7 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.2 3.5 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.0 4.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.0 2.0 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.0 7.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.9 3.6 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.8 3.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.8 3.1 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.7 3.0 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.7 8.1 GO:0051184 cofactor transporter activity(GO:0051184)
0.7 2.2 GO:0005536 glucose binding(GO:0005536)
0.7 2.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.6 1.8 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.6 0.6 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.6 1.2 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.6 4.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.6 1.7 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.6 2.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.6 3.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.6 2.8 GO:0008198 ferrous iron binding(GO:0008198)
0.5 2.2 GO:0016417 S-acyltransferase activity(GO:0016417)
0.5 3.7 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.5 1.6 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.5 2.1 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIID-class transcription factor binding(GO:0001094)
0.5 1.5 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 3.1 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.5 6.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.5 1.4 GO:0015440 peptide-transporting ATPase activity(GO:0015440) oligopeptide transmembrane transporter activity(GO:0035673)
0.5 1.4 GO:0004629 phospholipase C activity(GO:0004629)
0.5 3.6 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 1.3 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.4 1.2 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.4 4.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.6 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 1.5 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.4 3.3 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.4 6.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.4 2.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.4 1.8 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.3 1.0 GO:0097027 cyclin binding(GO:0030332) ubiquitin-protein transferase activator activity(GO:0097027)
0.3 2.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.3 1.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.3 3.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 3.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 1.4 GO:0004075 biotin carboxylase activity(GO:0004075)
0.3 2.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.3 1.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.3 2.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 3.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 0.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 1.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 1.3 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.2 1.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.2 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 3.1 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.2 1.1 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.2 0.6 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 0.2 GO:0015491 monovalent cation:proton antiporter activity(GO:0005451) solute:cation antiporter activity(GO:0015298) solute:proton antiporter activity(GO:0015299) cation:cation antiporter activity(GO:0015491)
0.2 1.6 GO:0010181 FMN binding(GO:0010181)
0.2 0.6 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2 1.4 GO:0030246 carbohydrate binding(GO:0030246)
0.2 1.0 GO:0017022 myosin binding(GO:0017022)
0.2 0.7 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.2 0.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 1.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 4.5 GO:0003684 damaged DNA binding(GO:0003684)
0.2 3.2 GO:0008301 DNA binding, bending(GO:0008301)
0.2 0.5 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.2 0.5 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 4.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.6 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 1.6 GO:0005516 calmodulin binding(GO:0005516)
0.1 3.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 2.2 GO:0031491 nucleosome binding(GO:0031491)
0.1 1.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.5 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.5 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 1.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 1.2 GO:0038023 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.1 0.6 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.4 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 1.1 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 3.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.2 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 0.2 GO:0032452 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) histone demethylase activity(GO:0032452) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 1.2 GO:0045182 translation regulator activity(GO:0045182)
0.1 2.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.2 GO:0045118 azole transporter activity(GO:0045118)
0.1 1.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 0.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.3 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 1.1 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 2.8 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 3.5 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 0.2 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.1 0.9 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 2.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 0.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.0 0.2 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0015293 symporter activity(GO:0015293)
0.0 0.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0004526 ribonuclease MRP activity(GO:0000171) ribonuclease P activity(GO:0004526)
0.0 1.7 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.2 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.1 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.0 GO:0019202 amino acid kinase activity(GO:0019202)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.6 2.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.5 1.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 0.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 61.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.1 PID ATM PATHWAY ATM pathway
0.0 0.1 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.8 2.5 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.5 2.0 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.4 1.4 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.3 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 2.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.8 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.1 0.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.6 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.1 0.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 60.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression