• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 2.134

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_115890247	51.178	NM_001159569 NM_001159570	Meis2	Meis homeobox 2
chr11_+_104092809	40.444		Mapt	microtubule-associated protein tau
chr18_+_64425037	32.934		St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr3_+_13471681	32.738		Ralyl	RALY RNA binding protein-like
chr8_+_86424565	26.320		Lphn1	latrophilin 1
chr8_+_73278577	25.819	NM_001166399 NM_009001	Rab3a	RAB3A, member RAS oncogene family
chr3_-_57651621	25.587	NM_019410	Pfn2	profilin 2
chr9_+_89804612	24.159	NM_001039655 NM_011245	Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1
chr4_-_151235861	24.086	NM_001081557 NM_001195565	Camta1	calmodulin binding transcription activator 1
chr11_+_104092793	23.288		Mapt	microtubule-associated protein tau
chr5_-_122822329	23.041		1500011H22Rik	RIKEN cDNA 1500011H22 gene
chr6_+_110595586	22.978	NM_177328	Grm7	glutamate receptor, metabotropic 7
chr18_-_25912453	22.802	NM_001146292 NM_001146293 NM_001146294 NM_001146295 NM_001174074 NM_133195	Celf4	CUGBP, Elav-like family member 4
chr16_+_18777032	22.329		Cldn5	claudin 5
chr9_-_53822931	21.679		Elmod1	ELMO domain containing 1
chr11_+_101329457	21.536		Rnd2	Rho family GTPase 2
chr11_+_104092749	21.450	NM_001038609 NM_010838	Mapt	microtubule-associated protein tau
chr7_-_17200285	21.059	NM_172739	Grlf1	glucocorticoid receptor DNA binding factor 1
chr2_-_168567422	21.044		Atp9a	ATPase, class II, type 9A
chr15_-_77137015	20.345		Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_-_168567602	20.319		Atp9a	ATPase, class II, type 9A
chr9_+_89804723	20.043		Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1
chr9_-_53823107	19.789	NM_177769	Elmod1	ELMO domain containing 1
chr5_-_77837037	19.168	NM_001159518 NM_008048	Igfbp7	insulin-like growth factor binding protein 7
chr3_-_107320881	18.746	NM_172271	Slc6a17	solute carrier family 6 (neurotransmitter transporter), member 17
chr5_+_37633353	18.662		Crmp1	collapsin response mediator protein 1
chr5_-_77836974	18.627		Igfbp7	insulin-like growth factor binding protein 7
chr18_-_25912171	18.534		Celf4	CUGBP, Elav-like family member 4
chr5_+_136363769	18.114	NM_013560	Hspb1	heat shock protein 1
chr16_+_18776936	17.996	NM_013805	Cldn5	claudin 5
chr9_-_102256709	17.985		Ephb1	Eph receptor B1
chr16_+_5885447	17.928		Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_-_80606704	17.884	NM_001039195 NM_001083806 NM_013540	Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr9_-_102256962	17.773	NM_001168296 NM_173447	Ephb1	Eph receptor B1
chr5_+_136363914	17.752		Hspb1	heat shock protein 1
chr16_+_18776955	17.526		Cldn5	claudin 5
chr5_+_136363810	17.201		Hspb1	heat shock protein 1
chr11_+_101329615	17.174	NM_009708	Rnd2	Rho family GTPase 2
chr18_-_16967754	17.079		Cdh2	cadherin 2
chr9_+_110148568	16.954		Cspg5	chondroitin sulfate proteoglycan 5
chr7_+_89319681	16.079		Sh3gl3	SH3-domain GRB2-like 3
chr16_-_18629938	16.064	NM_213614	Sept5	septin 5
chrX_-_70905384	15.650		Pnck	pregnancy upregulated non-ubiquitously expressed CaM kinase
chr3_-_80606500	15.622		Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr11_+_69154265	15.549		A030009H04Rik	RIKEN cDNA A030009H04 gene
chr15_+_101097276	15.543	NM_010444	Nr4a1	nuclear receptor subfamily 4, group A, member 1
chr11_-_116515602	15.526	NM_030206	Cygb	cytoglobin
chrX_-_70905062	15.479	NM_012040	Pnck	pregnancy upregulated non-ubiquitously expressed CaM kinase
chr1_-_42751652	15.359		2610017I09Rik	RIKEN cDNA 2610017I09 gene
chr2_+_138082301	15.315	NM_001025431	Btbd3	BTB (POZ) domain containing 3
chr9_-_56483379	15.286		Lingo1	leucine rich repeat and Ig domain containing 1
chr15_-_3533122	15.235	NM_001048178 NM_010284	Ghr	growth hormone receptor
chrX_+_10062237	14.958	NM_019634	Tspan7	tetraspanin 7
chr11_-_118770873	14.831	NM_001024931 NM_001039167 NM_001039168	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3
chr9_+_56785271	14.688	NM_133976	Imp3	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr1_-_194681914	14.655	NM_198247	Sertad4	SERTA domain containing 4
chr7_+_73007017	14.575	NM_011048	Pcsk6	proprotein convertase subtilisin/kexin type 6
chr6_+_88674398	14.555	NM_001166249 NM_011844	Mgll	monoglyceride lipase
chr7_+_52960585	14.481	NM_016974	Dbp	D site albumin promoter binding protein
chr2_-_168567436	14.306		Atp9a	ATPase, class II, type 9A
chr5_+_37633317	14.297	NM_001136058	Crmp1	collapsin response mediator protein 1
chr4_-_150482562	14.284		Camta1	calmodulin binding transcription activator 1
chr7_+_71646515	14.206	NM_007461	Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2
chr11_-_5965743	14.165	NM_001174053 NM_001174054 NM_007595	Camk2b	calcium/calmodulin-dependent protein kinase II, beta
chr18_-_16967557	14.010	NM_007664	Cdh2	cadherin 2
chr2_+_151368197	13.957	NM_008019	Fkbp1a	FK506 binding protein 1a
chr11_-_118770859	13.917		Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3
chr6_+_7505070	13.789	NM_009311	Tac1	tachykinin 1
chr11_-_116515361	13.788		Cygb	cytoglobin
chr4_+_155068566	13.735	NM_178699	B930041F14Rik	RIKEN cDNA B930041F14 gene
chr14_-_80171003	13.524	NM_001042726 NM_021543	Pcdh8	protocadherin 8
chr19_+_28909559	13.212	NM_009199	Slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr15_+_82105322	13.006	NM_011889	Sept3	septin 3
chr11_+_105451296	12.879	NM_181071	Tanc2	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr4_+_155068604	12.874		B930041F14Rik	RIKEN cDNA B930041F14 gene
chr3_-_57651409	12.776		Pfn2	profilin 2
chr19_+_6427922	12.456	NM_020253	Nrxn2	neurexin II
chr8_+_65430028	12.256	NM_023689	Spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr6_-_101327849	11.989	NM_018884	Pdzrn3	PDZ domain containing RING finger 3
chr8_+_72839642	11.945	NM_001163282 NM_138647	Gdf1 Lass1	growth differentiation factor 1 LAG1 homolog, ceramide synthase 1
chr13_-_56397911	11.687	NM_019568	Cxcl14	chemokine (C-X-C motif) ligand 14
chr14_-_109313333	11.598		Slitrk1	SLIT and NTRK-like family, member 1
chr14_-_109313447	11.588	NM_199065	Slitrk1	SLIT and NTRK-like family, member 1
chr13_+_64263131	11.563	NM_019986	Habp4	hyaluronic acid binding protein 4
chr16_-_4420415	11.485		Adcy9	adenylate cyclase 9
chr4_-_81088575	11.247	NM_010820	Mpdz	multiple PDZ domain protein
chr11_-_5965544	11.113		Camk2b	calcium/calmodulin-dependent protein kinase II, beta
chr3_-_80606641	10.990		Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr14_+_68701838	10.964	NM_010910	Nefl	neurofilament, light polypeptide
chr2_+_151368331	10.893		Fkbp1a	FK506 binding protein 1a
chr17_+_36116923	10.844		Gnl1	guanine nucleotide binding protein-like 1
chr13_+_58907999	10.822		Ntrk2	neurotrophic tyrosine kinase, receptor, type 2
chr11_-_5965555	10.770		Camk2b	calcium/calmodulin-dependent protein kinase II, beta
chr5_+_74591290	10.664		Rasl11b	RAS-like, family 11, member B
chr2_-_165060188	10.662	NM_174988	Cdh22	cadherin 22
chr13_-_56397521	10.545		Cxcl14	chemokine (C-X-C motif) ligand 14
chr7_+_107756292	10.537		Rab6	RAB6, member RAS oncogene family
chr7_-_31230564	10.506		Aplp1	amyloid beta (A4) precursor-like protein 1
chr7_+_25292201	10.431		Zfp428	zinc finger protein 428
chr13_+_58907929	10.373		Ntrk2	neurotrophic tyrosine kinase, receptor, type 2
chr8_+_120807674	10.373		Cdh13	cadherin 13
chr7_-_28118628	10.269	NM_001113549	Ltbp4	latent transforming growth factor beta binding protein 4
chr2_+_22478131	10.241		Gad2	glutamic acid decarboxylase 2
chr11_-_88725811	10.141		Akap1	A kinase (PRKA) anchor protein 1
chr7_-_149280946	10.092		Dusp8	dual specificity phosphatase 8
chr8_-_4259126	10.072	NM_183315	Ctxn1	cortexin 1
chr8_-_124175827	10.067	NM_080855	Zcchc14	zinc finger, CCHC domain containing 14
chr4_+_104829963	10.019		Ppap2b	phosphatidic acid phosphatase type 2B
chr14_-_109313298	10.013		Slitrk1	SLIT and NTRK-like family, member 1
chr9_-_49311823	10.002		Ncam1	neural cell adhesion molecule 1
chr7_+_30074296	9.960	NM_026731	Ppp1r14a	protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr7_-_31230463	9.924		Aplp1	amyloid beta (A4) precursor-like protein 1
chr7_+_138079669	9.889	NM_019564	Htra1	HtrA serine peptidase 1
chr7_+_107756205	9.861		Rab6	RAB6, member RAS oncogene family
chr11_-_6375845	9.802	NM_011221	Purb	purine rich element binding protein B
chr10_-_31165691	9.753	NM_009413	Tpd52l1	tumor protein D52-like 1
chr5_+_25265761	9.731	NM_001004365	Actr3b	ARP3 actin-related protein 3 homolog B (yeast)
chr5_+_111847185	9.714	NM_001081235	Mn1	meningioma 1
chr4_-_71861939	9.687	NM_011599	Tle1	transducin-like enhancer of split 1, homolog of Drosophila E(spl)
chr11_-_83881811	9.666	NM_019819	Dusp14	dual specificity phosphatase 14
chr4_-_133053867	9.593		Trnp1	TMF1-regulated nuclear protein 1
chr11_-_7113547	9.578		Igfbp3	insulin-like growth factor binding protein 3
chr17_+_25945986	9.569	NM_001164225	Fbxl16	F-box and leucine-rich repeat protein 16
chr2_+_22478062	9.454		Gad2	glutamic acid decarboxylase 2
chrX_-_156576312	9.452		Pdha1	pyruvate dehydrogenase E1 alpha 1
chr19_-_46392378	9.435		Psd	pleckstrin and Sec7 domain containing
chr7_-_112630662	9.414	NM_028444	Prkcdbp	protein kinase C, delta binding protein
chr9_+_59598963	9.347	NM_173018	Myo9a	myosin IXa
chr6_-_142456402	9.298	NM_008492	Ldhb	lactate dehydrogenase B
chrX_-_149471740	9.240	NM_023788	Mageh1	melanoma antigen, family H, 1
chr19_+_27291507	9.234	NM_001161420 NM_013703	Vldlr	very low density lipoprotein receptor
chr7_+_107756069	9.228	NM_001163663 NM_024287	Rab6	RAB6, member RAS oncogene family
chr5_-_136410216	9.203		Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr11_-_41996141	9.197	NM_010250	Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr1_+_184695026	9.161	NM_144796	Susd4	sushi domain containing 4
chr12_-_113749361	9.119		Tmem179	transmembrane protein 179
chr6_-_23789419	9.098		Cadps2	Ca2+-dependent activator protein for secretion 2
chrX_+_155852439	9.089	NM_001081124	Mtap7d2	MAP7 domain containing 2
chr4_+_155068450	9.083		B930041F14Rik	RIKEN cDNA B930041F14 gene
chr3_+_145421621	9.073	NM_026993	Ddah1	dimethylarginine dimethylaminohydrolase 1
chr13_+_58907953	9.056	NM_008745	Ntrk2	neurotrophic tyrosine kinase, receptor, type 2
chr2_-_165060352	9.006		Cdh22	cadherin 22
chr8_+_81552335	8.995	NM_178267	Zfp827	zinc finger protein 827
chr8_+_120807621	8.969	NM_019707	Cdh13	cadherin 13
chr11_-_69418965	8.921		Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide
chr2_-_163298253	8.913	NM_173397	Fitm2	fat storage-inducing transmembrane protein 2
chr6_-_23789259	8.912	NM_153163	Cadps2	Ca2+-dependent activator protein for secretion 2
chr4_-_154273134	8.900	NM_025582	2810405K02Rik	RIKEN cDNA 2810405K02 gene
chr7_+_25292375	8.890		Zfp428	zinc finger protein 428
chr4_+_5571316	8.834	NM_173426	Fam110b	family with sequence similarity 110, member B
chr15_+_78744802	8.824		Pdxp	pyridoxal (pyridoxine, vitamin B6) phosphatase
chr13_+_42804911	8.814	NM_001005740	Phactr1	phosphatase and actin regulator 1
chr16_-_45724720	8.773		Tagln3	transgelin 3
chrX_-_156576261	8.745	NM_008810	Pdha1	pyruvate dehydrogenase E1 alpha 1
chr2_+_90730089	8.742		C1qtnf4	C1q and tumor necrosis factor related protein 4
chr3_+_52845510	8.689		Lhfp	lipoma HMGIC fusion partner
chr9_-_49607164	8.680	NM_001081445 NM_001113204 NM_010875	Ncam1	neural cell adhesion molecule 1
chr5_-_122821971	8.614	NM_026883	1500011H22Rik	RIKEN cDNA 1500011H22 gene
chr7_+_25292105	8.604	NM_146183	Zfp428	zinc finger protein 428
chr2_+_102498839	8.568	NM_001077514	Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_69506165	8.420		Epb4.1l3	erythrocyte protein band 4.1-like 3
chr11_-_7113386	8.388		Igfbp3	insulin-like growth factor binding protein 3
chr19_+_10463540	8.383	NM_018801 NM_173067 NM_173068	Syt7	synaptotagmin VII
chr15_+_78744576	8.375		Pdxp	pyridoxal (pyridoxine, vitamin B6) phosphatase
chr4_+_115894231	8.241		Pik3r3	phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_+_60466568	8.231		Abi2	abl-interactor 2
chr16_-_45724422	8.142	NM_019754	Tagln3	transgelin 3
chr19_+_45092581	8.078	NM_001130526	Lzts2	leucine zipper, putative tumor suppressor 2
chr14_-_71018208	8.060		Epb4.9	erythrocyte protein band 4.9
chr7_+_52960702	8.055		Dbp	D site albumin promoter binding protein
chr14_-_68742863	8.047		Nefm	neurofilament, medium polypeptide
chr12_-_113749313	8.001		Tmem179	transmembrane protein 179
chr9_+_43893029	7.990		Usp2	ubiquitin specific peptidase 2
chr19_-_40588193	7.986		Sorbs1	sorbin and SH3 domain containing 1
chr12_-_73337707	7.975	NM_001007596	Rtn1	reticulon 1
chr19_-_47165137	7.936		Usmg5	upregulated during skeletal muscle growth 5
chr15_+_78744862	7.930		Pdxp	pyridoxal (pyridoxine, vitamin B6) phosphatase
chr5_+_125343060	7.914	NM_001081750	Zfp664	zinc finger protein 664
chr18_-_14002490	7.880		Zfp521	zinc finger protein 521
chr3_+_105255247	7.851	NM_001039347	Kcnd3	potassium voltage-gated channel, Shal-related family, member 3
chr11_-_41995688	7.831		Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr14_+_99697933	7.829		Klf5	Kruppel-like factor 5
chr3_+_96400524	7.787	NM_001024851	Ankrd34a	ankyrin repeat domain 34A
chr11_-_41996099	7.786		Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr10_-_79723633	7.765	NM_010255	Gamt	guanidinoacetate methyltransferase
chr19_+_43514902	7.743	NM_031396	Cnnm1	cyclin M1
chr3_+_133903056	7.733	NM_001004367	Cxxc4	CXXC finger 4
chr12_+_100158783	7.729	NM_029553 NM_198311	Ttc8	tetratricopeptide repeat domain 8
chr12_-_73337534	7.725		Rtn1	reticulon 1
chr4_-_91042997	7.718	NM_001177883	Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr17_+_86567003	7.670	NM_011104	Prkce	protein kinase C, epsilon
chr9_+_43892984	7.668	NM_198091	Usp2	ubiquitin specific peptidase 2
chr15_+_78744328	7.655	NM_020271	Pdxp	pyridoxal (pyridoxine, vitamin B6) phosphatase
chrX_-_56387239	7.600		Fgf13	fibroblast growth factor 13
chr2_+_90729768	7.589		C1qtnf4	C1q and tumor necrosis factor related protein 4
chr8_-_87323958	7.578		Nfix	nuclear factor I/X
chr12_-_113749363	7.557	NM_178915	Tmem179	transmembrane protein 179
chr10_-_80363422	7.540		Timm13	translocase of inner mitochondrial membrane 13 homolog (yeast)
chr10_-_31165613	7.524		Tpd52l1	tumor protein D52-like 1
chr19_-_47165086	7.504	NM_023211	Usmg5	upregulated during skeletal muscle growth 5

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.71	4.65e-19	GO:0071841	cellular component organization or biogenesis at cellular level
1.35	9.18e-19	GO:0044237	cellular metabolic process
1.72	2.64e-18	GO:0071842	cellular component organization at cellular level
1.53	1.90e-16	GO:0032502	developmental process
1.53	6.72e-15	GO:0007275	multicellular organismal development
1.53	1.52e-14	GO:0071840	cellular component organization or biogenesis
1.90	5.92e-14	GO:0007399	nervous system development
1.53	7.49e-14	GO:0016043	cellular component organization
1.42	1.64e-13	GO:0019222	regulation of metabolic process
1.53	9.76e-13	GO:0048856	anatomical structure development
1.78	2.13e-12	GO:0009653	anatomical structure morphogenesis
1.44	2.18e-12	GO:0031323	regulation of cellular metabolic process
1.29	2.54e-12	GO:0044238	primary metabolic process
1.36	3.82e-12	GO:0044260	cellular macromolecule metabolic process
1.26	4.38e-12	GO:0008152	metabolic process
1.54	1.08e-11	GO:0048731	system development
1.99	4.41e-11	GO:0022008	neurogenesis
2.02	4.87e-11	GO:0048699	generation of neurons
1.40	3.98e-10	GO:0080090	regulation of primary metabolic process
1.93	4.50e-10	GO:0048468	cell development
1.57	8.28e-10	GO:0030154	cell differentiation
1.55	1.29e-09	GO:0048869	cellular developmental process
1.67	1.50e-09	GO:0023051	regulation of signaling
1.41	3.03e-09	GO:0009058	biosynthetic process
1.41	9.95e-09	GO:0044249	cellular biosynthetic process
2.13	1.11e-08	GO:0030182	neuron differentiation
1.37	1.15e-08	GO:0034641	cellular nitrogen compound metabolic process
1.14	1.96e-08	GO:0009987	cellular process
2.27	2.09e-08	GO:0048666	neuron development
1.36	2.20e-08	GO:0006807	nitrogen compound metabolic process
1.50	3.05e-08	GO:0048523	negative regulation of cellular process
1.73	5.46e-08	GO:0010646	regulation of cell communication
1.37	6.08e-08	GO:0060255	regulation of macromolecule metabolic process
1.28	8.40e-08	GO:0043170	macromolecule metabolic process
2.44	9.75e-08	GO:0000904	cell morphogenesis involved in differentiation
1.43	1.00e-07	GO:0010467	gene expression
2.38	1.32e-07	GO:0031175	neuron projection development
1.38	1.35e-07	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.16	3.36e-07	GO:0000902	cell morphogenesis
2.09	5.84e-07	GO:0032989	cellular component morphogenesis
1.39	1.38e-06	GO:0009889	regulation of biosynthetic process
1.39	1.94e-06	GO:0010468	regulation of gene expression
1.39	1.96e-06	GO:0031326	regulation of cellular biosynthetic process
2.48	1.97e-06	GO:0048812	neuron projection morphogenesis
1.44	2.59e-06	GO:0044267	cellular protein metabolic process
1.62	2.88e-06	GO:0009966	regulation of signal transduction
1.38	2.98e-06	GO:0051171	regulation of nitrogen compound metabolic process
1.42	3.14e-06	GO:0048519	negative regulation of biological process
1.38	3.51e-06	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.01	4.85e-06	GO:0030030	cell projection organization
2.40	2.91e-05	GO:0048667	cell morphogenesis involved in neuron differentiation
1.35	3.07e-05	GO:0048518	positive regulation of biological process
1.51	3.43e-05	GO:0065009	regulation of molecular function
2.46	3.44e-05	GO:0007409	axonogenesis
1.37	4.81e-05	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.38	5.75e-05	GO:0016070	RNA metabolic process
1.37	6.73e-05	GO:0009059	macromolecule biosynthetic process
2.17	7.64e-05	GO:0032990	cell part morphogenesis
1.56	7.89e-05	GO:0050790	regulation of catalytic activity
1.71	9.04e-05	GO:0045595	regulation of cell differentiation
2.17	9.56e-05	GO:0048858	cell projection morphogenesis
1.35	9.91e-05	GO:0010556	regulation of macromolecule biosynthetic process
2.82	1.03e-04	GO:0007005	mitochondrion organization
1.37	1.09e-04	GO:0034645	cellular macromolecule biosynthetic process
1.36	1.38e-04	GO:0048522	positive regulation of cellular process
1.68	1.54e-04	GO:0009790	embryo development
2.02	1.56e-04	GO:0009968	negative regulation of signal transduction
1.49	1.65e-04	GO:0006996	organelle organization
1.78	1.72e-04	GO:0009887	organ morphogenesis
1.30	2.15e-04	GO:0051179	localization
2.37	2.49e-04	GO:0030900	forebrain development
1.33	3.25e-04	GO:0090304	nucleic acid metabolic process
1.94	3.78e-04	GO:0023057	negative regulation of signaling
1.42	3.91e-04	GO:0048513	organ development
2.05	4.05e-04	GO:0007420	brain development
1.94	4.15e-04	GO:0010648	negative regulation of cell communication
1.79	4.41e-04	GO:0071844	cellular component assembly at cellular level
1.58	4.68e-04	GO:0044085	cellular component biogenesis
1.34	9.50e-04	GO:0051252	regulation of RNA metabolic process
1.43	9.53e-04	GO:0044281	small molecule metabolic process
1.55	1.10e-03	GO:0050793	regulation of developmental process
1.56	1.15e-03	GO:0031324	negative regulation of cellular metabolic process
1.87	1.18e-03	GO:0007417	central nervous system development
1.44	1.59e-03	GO:0051239	regulation of multicellular organismal process
2.35	1.60e-03	GO:0050804	regulation of synaptic transmission
2.11	1.63e-03	GO:0034622	cellular macromolecular complex assembly
1.64	1.86e-03	GO:0031327	negative regulation of cellular biosynthetic process
1.34	1.88e-03	GO:0006355	regulation of transcription, DNA-dependent
1.88	2.45e-03	GO:0007267	cell-cell signaling
1.54	2.48e-03	GO:0010605	negative regulation of macromolecule metabolic process
2.12	2.56e-03	GO:0007268	synaptic transmission
1.68	2.99e-03	GO:0019220	regulation of phosphate metabolic process
1.68	2.99e-03	GO:0051174	regulation of phosphorus metabolic process
2.07	3.14e-03	GO:0006412	translation
1.67	3.97e-03	GO:0007154	cell communication
1.69	4.09e-03	GO:0051253	negative regulation of RNA metabolic process
1.51	4.10e-03	GO:0009892	negative regulation of metabolic process
2.24	4.20e-03	GO:0051969	regulation of transmission of nerve impulse
2.06	4.39e-03	GO:0006140	regulation of nucleotide metabolic process
1.38	4.79e-03	GO:0065008	regulation of biological quality
1.84	4.89e-03	GO:0040008	regulation of growth
1.99	4.92e-03	GO:0034621	cellular macromolecular complex subunit organization
4.54	5.10e-03	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway
1.64	5.29e-03	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30	5.35e-03	GO:0051234	establishment of localization
1.60	5.42e-03	GO:0009890	negative regulation of biosynthetic process
1.64	5.54e-03	GO:0051172	negative regulation of nitrogen compound metabolic process
2.17	5.58e-03	GO:0031644	regulation of neurological system process
3.61	5.87e-03	GO:0050808	synapse organization
2.65	6.40e-03	GO:0006184	GTP catabolic process
1.88	6.42e-03	GO:0007610	behavior
2.05	6.82e-03	GO:0031329	regulation of cellular catabolic process
1.29	6.99e-03	GO:0019538	protein metabolic process
1.93	7.40e-03	GO:0019226	transmission of nerve impulse
1.93	7.40e-03	GO:0035637	multicellular organismal signaling
1.64	7.43e-03	GO:0010629	negative regulation of gene expression
2.58	7.46e-03	GO:0030111	regulation of Wnt receptor signaling pathway
2.04	7.57e-03	GO:0009199	ribonucleoside triphosphate metabolic process
1.56	7.60e-03	GO:0022607	cellular component assembly
1.29	7.68e-03	GO:0006810	transport
1.94	7.71e-03	GO:0009894	regulation of catabolic process
1.67	7.73e-03	GO:0045892	negative regulation of transcription, DNA-dependent
2.32	8.39e-03	GO:0043062	extracellular structure organization
1.62	8.81e-03	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.74	1.01e-02	GO:0048585	negative regulation of response to stimulus
2.33	1.04e-02	GO:0016055	Wnt receptor signaling pathway
2.13	1.11e-02	GO:0009154	purine ribonucleotide catabolic process
2.00	1.11e-02	GO:0009141	nucleoside triphosphate metabolic process
1.88	1.16e-02	GO:0007167	enzyme linked receptor protein signaling pathway
3.79	1.17e-02	GO:0030177	positive regulation of Wnt receptor signaling pathway
1.71	1.17e-02	GO:0010647	positive regulation of cell communication
1.79	1.20e-02	GO:0048598	embryonic morphogenesis
2.01	1.44e-02	GO:0009205	purine ribonucleoside triphosphate metabolic process
2.55	1.45e-02	GO:0030324	lung development
1.70	1.45e-02	GO:0023056	positive regulation of signaling
1.59	1.46e-02	GO:0010558	negative regulation of macromolecule biosynthetic process
2.06	1.53e-02	GO:0006195	purine nucleotide catabolic process
2.13	1.56e-02	GO:0009207	purine ribonucleoside triphosphate catabolic process
1.71	1.69e-02	GO:0072358	cardiovascular system development
1.71	1.69e-02	GO:0072359	circulatory system development
2.09	1.74e-02	GO:0009261	ribonucleotide catabolic process
2.12	1.74e-02	GO:0009203	ribonucleoside triphosphate catabolic process
1.48	1.76e-02	GO:0035556	intracellular signal transduction
1.37	1.83e-02	GO:0006464	protein modification process
1.80	1.97e-02	GO:0060284	regulation of cell development
2.51	1.98e-02	GO:0030323	respiratory tube development
1.36	2.01e-02	GO:0006351	transcription, DNA-dependent
1.52	2.04e-02	GO:0009888	tissue development
2.10	2.18e-02	GO:0009146	purine nucleoside triphosphate catabolic process
1.89	2.22e-02	GO:0035295	tube development
1.35	2.24e-02	GO:0032774	RNA biosynthetic process
1.97	2.37e-02	GO:0001501	skeletal system development
1.91	2.44e-02	GO:0045596	negative regulation of cell differentiation
1.62	2.50e-02	GO:0042325	regulation of phosphorylation
1.97	2.61e-02	GO:0009144	purine nucleoside triphosphate metabolic process
1.93	2.66e-02	GO:0009150	purine ribonucleotide metabolic process
1.91	2.80e-02	GO:0009259	ribonucleotide metabolic process
2.01	2.85e-02	GO:0072523	purine-containing compound catabolic process
1.83	2.90e-02	GO:0006163	purine nucleotide metabolic process
1.47	3.09e-02	GO:0032879	regulation of localization
2.45	3.10e-02	GO:0046039	GTP metabolic process
2.49	3.25e-02	GO:0007411	axon guidance
1.78	3.67e-02	GO:0072521	purine-containing compound metabolic process
2.05	3.74e-02	GO:0009143	nucleoside triphosphate catabolic process
1.12	3.79e-02	GO:0065007	biological regulation
2.14	3.84e-02	GO:0071843	cellular component biogenesis at cellular level
1.95	3.98e-02	GO:0045664	regulation of neuron differentiation
2.57	4.07e-02	GO:0021537	telencephalon development
1.79	4.19e-02	GO:0051093	negative regulation of developmental process
1.12	4.62e-02	GO:0050789	regulation of biological process
1.94	4.81e-02	GO:0007264	small GTPase mediated signal transduction
2.74	4.85e-02	GO:0060828	regulation of canonical Wnt receptor signaling pathway
1.34	4.93e-02	GO:0043412	macromolecule modification
1.62	4.96e-02	GO:0065003	macromolecular complex assembly

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.33	2.46e-47	GO:0005622	intracellular
1.33	4.36e-44	GO:0044424	intracellular part
1.40	1.43e-38	GO:0005737	cytoplasm
1.32	3.71e-31	GO:0043229	intracellular organelle
1.32	4.03e-31	GO:0043226	organelle
1.32	1.21e-24	GO:0043227	membrane-bounded organelle
1.32	1.69e-24	GO:0043231	intracellular membrane-bounded organelle
1.41	2.83e-21	GO:0044444	cytoplasmic part
1.13	9.35e-19	GO:0005623	cell
1.13	9.35e-19	GO:0044464	cell part
1.34	1.04e-12	GO:0005634	nucleus
2.27	3.63e-11	GO:0045202	synapse
1.48	4.52e-10	GO:0043228	non-membrane-bounded organelle
1.48	4.52e-10	GO:0043232	intracellular non-membrane-bounded organelle
1.73	3.89e-09	GO:0042995	cell projection
1.61	5.34e-09	GO:0005739	mitochondrion
1.32	6.97e-09	GO:0044422	organelle part
1.32	1.50e-08	GO:0044446	intracellular organelle part
2.01	1.72e-08	GO:0043005	neuron projection
1.36	5.11e-08	GO:0032991	macromolecular complex
2.51	5.90e-08	GO:0030424	axon
2.06	1.71e-07	GO:0030529	ribonucleoprotein complex
1.55	3.09e-07	GO:0005829	cytosol
2.21	9.36e-07	GO:0044456	synapse part
1.60	1.36e-06	GO:0000267	cell fraction
1.68	1.86e-06	GO:0005626	insoluble fraction
1.67	5.25e-06	GO:0005624	membrane fraction
1.48	3.71e-05	GO:0005856	cytoskeleton
1.91	1.02e-04	GO:0044463	cell projection part
2.03	1.49e-04	GO:0043025	neuronal cell body
2.70	1.81e-04	GO:0033267	axon part
2.46	2.23e-04	GO:0005840	ribosome
1.93	7.21e-04	GO:0044297	cell body
1.71	9.34e-04	GO:0044429	mitochondrial part
1.43	3.35e-03	GO:0031090	organelle membrane
3.01	4.50e-03	GO:0044309	neuron spine
1.60	6.69e-03	GO:0030054	cell junction
1.21	8.14e-03	GO:0071944	cell periphery
1.33	8.87e-03	GO:0044459	plasma membrane part
2.93	1.14e-02	GO:0043197	dendritic spine
1.21	1.22e-02	GO:0005886	plasma membrane
3.75	1.86e-02	GO:0030175	filopodium
1.68	2.12e-02	GO:0005740	mitochondrial envelope
2.12	2.31e-02	GO:0031252	cell leading edge
1.24	2.82e-02	GO:0043234	protein complex
1.84	2.82e-02	GO:0030425	dendrite
2.18	3.21e-02	GO:0005759	mitochondrial matrix
2.14	3.24e-02	GO:0045211	postsynaptic membrane
1.76	3.32e-02	GO:0019866	organelle inner membrane
1.78	3.51e-02	GO:0005743	mitochondrial inner membrane
1.67	4.04e-02	GO:0031966	mitochondrial membrane
1.82	4.18e-02	GO:0015629	actin cytoskeleton

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.47	1.02e-29	GO:0005515	protein binding
1.25	2.26e-26	GO:0005488	binding
1.55	3.90e-11	GO:0000166	nucleotide binding
1.45	8.62e-06	GO:0032555	purine ribonucleotide binding
1.90	8.91e-06	GO:0019904	protein domain specific binding
1.45	9.04e-06	GO:0032553	ribonucleotide binding
1.45	1.14e-05	GO:0035639	purine ribonucleoside triphosphate binding
1.45	1.20e-05	GO:0017076	purine nucleotide binding
2.13	1.76e-05	GO:0005525	GTP binding
1.73	2.93e-05	GO:0003723	RNA binding
3.06	7.85e-05	GO:0019838	growth factor binding
2.03	9.91e-05	GO:0019001	guanyl nucleotide binding
2.03	9.91e-05	GO:0032561	guanyl ribonucleotide binding
1.33	1.62e-04	GO:0003676	nucleic acid binding
1.60	2.97e-04	GO:0019899	enzyme binding
1.90	3.49e-04	GO:0060589	nucleoside-triphosphatase regulator activity
1.60	4.78e-04	GO:0030234	enzyme regulator activity
1.86	1.17e-03	GO:0030695	GTPase regulator activity
1.26	1.18e-03	GO:0046872	metal ion binding
7.31	1.62e-03	GO:0030546	receptor activator activity
1.96	1.85e-03	GO:0008047	enzyme activator activity
1.25	1.90e-03	GO:0043169	cation binding
1.25	1.96e-03	GO:0043167	ion binding
2.44	1.98e-03	GO:0003924	GTPase activity
1.52	3.92e-03	GO:0030528	transcription regulator activity
1.56	4.23e-03	GO:0042802	identical protein binding
2.03	4.71e-03	GO:0005083	small GTPase regulator activity
1.18	7.79e-03	GO:0003824	catalytic activity
1.79	8.00e-03	GO:0005198	structural molecule activity
9.90	1.75e-02	GO:0003706	ligand-regulated transcription factor activity
2.02	3.62e-02	GO:0005096	GTPase activator activity
11.88	3.73e-02	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity
5.28	3.74e-02	GO:0031418	L-ascorbic acid binding
2.15	3.81e-02	GO:0031406	carboxylic acid binding
1.75	4.13e-02	GO:0032403	protein complex binding
2.58	4.85e-02	GO:0030165	PDZ domain binding