Motif ID: AIRE.p2

Z-value: 1.340


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
Aire 11634 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Airechr10_-_775062670.181.6e-02Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_70510714 22.942 NM_011727
Xlr3c
X-linked lymphocyte-regulated 3C
chrX_+_70437517 19.008 NM_001081643
Xlr3b
X-linked lymphocyte-regulated 3B
chrX_-_70342343 15.050 NM_001110784
Xlr3a
X-linked lymphocyte-regulated 3A
chr11_+_83251195 14.578 NM_025492
1700020L24Rik
RIKEN cDNA 1700020L24 gene
chr6_+_48689045 13.021 NM_008376
NM_175860
Gimap1

GTPase, IMAP family member 1

chr6_+_48597232 12.478 NM_001077410
NM_212486
Gimap8

GTPase, IMAP family member 8

chrX_-_7544940 12.133 NM_008089
Gata1
GATA binding protein 1
chr4_+_15211137 11.233 Tmem64
transmembrane protein 64
chr11_+_83037063 10.579 AI662270
expressed sequence AI662270
chr14_+_51748742 10.492 NM_030098
Rnase6
ribonuclease, RNase A family, 6
chr3_+_41419561 9.934 Phf17
PHD finger protein 17
chr10_-_61960613 9.752 Srgn
serglycin
chr13_+_24706474 9.369 NM_178658
Fam65b
family with sequence similarity 65, member B
chr10_+_40290141 9.003 NM_027572
Slc22a16
solute carrier family 22 (organic cation transporter), member 16
chr16_+_20128178 8.793 Klhl24
kelch-like 24 (Drosophila)
chr14_-_122314994 7.671 NM_182806
Gpr18
G protein-coupled receptor 18
chr19_+_29441927 7.460 NM_021893
Cd274
CD274 antigen
chr19_-_4190836 7.407 NM_178650
Tbc1d10c
TBC1 domain family, member 10c
chr19_+_12873115 6.974 Lpxn
leupaxin
chr10_+_126504125 6.546


chr7_-_108709378 6.487 Art2a-ps
ADP-ribosyltransferase 2a, pseudogene
chr4_+_150302107 6.409 NM_001077509
Tnfrsf9
tumor necrosis factor receptor superfamily, member 9
chr1_+_19202046 6.317 NM_001025305
Tcfap2b
transcription factor AP-2 beta
chr11_-_58615400 6.031 NM_001162878
NM_029283
Fam183b

family with sequence similarity 183, member B

chr3_+_105707338 6.030 NM_009631
Adora3
adenosine A3 receptor
chr13_-_60998747 5.994 NM_001145801
NM_007797
Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr19_+_12873063 5.990 NM_134152
Lpxn
leupaxin
chr14_-_25306261 5.966 NM_001081247
Polr3a
polymerase (RNA) III (DNA directed) polypeptide A
chr7_+_29052821 5.881 NM_198425
Eid2
EP300 interacting inhibitor of differentiation 2
chr15_-_76701806 5.763 Zfp251
zinc finger protein 251
chr6_-_127075853 5.748 Ccnd2
cyclin D2
chr6_+_136467315 5.736 NM_019426
Atf7ip
activating transcription factor 7 interacting protein
chr14_-_59797556 5.690 NM_001004158
Gm5142
predicted gene 5142
chr8_-_26707934 5.682 NM_173012
Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr10_-_80962881 5.669 NM_010102
S1pr4
sphingosine-1-phosphate receptor 4
chr15_-_76701864 5.655 NM_001007568
Zfp251
zinc finger protein 251
chr8_+_90812964 5.630 NM_001037723
Adcy7
adenylate cyclase 7
chr17_-_81464406 5.622 NM_028138
Thumpd2
THUMP domain containing 2
chr5_-_123183537 5.580 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr7_+_51268047 5.569 NM_010115
NM_010644
Egfbp2
Klk1b26
epidermal growth factor binding protein type B
kallikrein 1-related petidase b26
chr18_+_74442753 5.444 NM_028948
Ccdc11
coiled-coil domain containing 11
chr19_+_4154645 5.437 NM_016933
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr10_-_129717244 5.417 NM_007501
Neurod4
neurogenic differentiation 4
chr1_+_46123582 5.291 NM_001160386
Dnahc7b
dynein, axonemal, heavy chain 7B
chr14_-_25306175 5.260 Polr3a
polymerase (RNA) III (DNA directed) polypeptide A
chr5_+_114580397 5.234 NM_001040691
Ung
uracil DNA glycosylase
chr16_+_33500899 5.213 Zfp148
zinc finger protein 148
chr17_+_23949101 5.087 Srrm2
serine/arginine repetitive matrix 2
chr6_-_122289630 5.078 Phc1
polyhomeotic-like 1 (Drosophila)
chr1_-_152011986 5.005


chr7_+_52877180 4.972 NM_001018013
Izumo1
izumo sperm-egg fusion 1
chr14_-_122364309 4.968 NM_183031
Gpr183
G protein-coupled receptor 183
chr7_+_13466525 4.956 NM_153802
Zfp128
zinc finger protein 128
chr12_+_16817772 4.860 E2f6
E2F transcription factor 6
chr5_+_106039499 4.822 Lrrc8c
leucine rich repeat containing 8 family, member C
chr6_-_135068260 4.821 NM_053118
Gprc5d
G protein-coupled receptor, family C, group 5, member D
chr8_+_107951514 4.815 NM_001033371
NM_001170789
Lrrc36

leucine rich repeat containing 36

chr9_-_106378454 4.764 Parp3
poly (ADP-ribose) polymerase family, member 3
chr1_+_169298077 4.755 Aldh9a1
aldehyde dehydrogenase 9, subfamily A1
chr17_+_34375847 4.701 NM_010389
H2-Ob
histocompatibility 2, O region beta locus
chr6_+_91828040 4.693 NM_172730
C130022K22Rik
RIKEN cDNA C130022K22 gene
chr11_-_107209443 4.635 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_+_134961629 4.599 NM_026360
Ddx47
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr1_+_21339757 4.593 NM_183322
Khdc1a
KH domain containing 1A
chr11_+_31900378 4.547 NM_008741
Nsg2
neuron specific gene family member 2
chr6_-_66629677 4.493 NM_134167
Vmn1r35
vomeronasal 1 receptor 35
chrX_-_159402465 4.475 S100g
S100 calcium binding protein G
chr4_-_151665770 4.470 NM_008237
Hes3
hairy and enhancer of split 3 (Drosophila)
chr7_+_65913571 4.449 NM_009728
Atp10a
ATPase, class V, type 10A
chr12_-_80084464 4.417 NM_001170401
Tmem229b
transmembrane protein 229B
chr12_+_77471173 4.385 NM_178744
Zbtb1
zinc finger and BTB domain containing 1
chr1_+_40497472 4.379 NM_001025602
Il1rl1
interleukin 1 receptor-like 1
chr13_-_67710581 4.358 AA987161
expressed sequence AA987161
chr11_-_54601133 4.217 Cdc42se2
CDC42 small effector 2
chr9_+_72122705 4.192 NM_146224
Zfp280d
zinc finger protein 280D
chr4_+_62220880 4.134 NM_019492
Rgs3
regulator of G-protein signaling 3
chr10_-_62342761 4.117 NM_027384
Tet1
tet oncogene 1
chr16_-_11137100 4.111 Zc3h7a
zinc finger CCCH type containing 7 A
chr8_-_74150754 4.066 Unc13a
unc-13 homolog A (C. elegans)
chr4_-_120781830 4.026 NM_001081312
Tmco2
transmembrane and coiled-coil domains 2
chr16_+_49913305 3.960 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr15_-_102993714 3.957 NM_027885
Smug1
single-strand selective monofunctional uracil DNA glycosylase
chr8_+_35178083 3.939 NM_001126314
Mboat4
membrane bound O-acyltransferase domain containing 4
chr12_+_85758189 3.930 Rnf113a2
ring finger protein 113A2
chr12_+_114727721 3.921 NM_001009545
Adam6b
a disintegrin and metallopeptidase domain 6B
chr16_+_34651296 3.918 NM_030744
Ropn1
ropporin, rhophilin associated protein 1
chr4_+_130469048 3.916 Laptm5
lysosomal-associated protein transmembrane 5
chr13_+_113450958 3.902 NM_178746
Slc38a9
solute carrier family 38, member 9
chr7_-_85992096 3.894 NM_029585
Det1
de-etiolated homolog 1 (Arabidopsis)
chr10_-_61970481 3.857 NM_011157
Srgn
serglycin
chr14_-_66211842 3.823 NM_028811
Elp3
elongation protein 3 homolog (S. cerevisiae)
chr17_+_25960571 3.820 NM_173741
Wdr24
WD repeat domain 24
chr3_-_152003317 3.812 NM_001162375
NM_174868
Fam73a

family with sequence similarity 73, member A

chr11_-_94834751 3.807 NM_001136080
Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
chr13_+_54167169 3.761 NM_027324
Sfxn1
sideroflexin 1
chr1_-_88284715 3.729 NM_010341
Nmur1
neuromedin U receptor 1
chr16_-_55934909 3.695 NM_001159364
NM_001159365
NM_001159366
NM_028815
Cep97



centrosomal protein 97



chr5_-_74023659 3.675 NM_153568
Lrrc66
leucine rich repeat containing 66
chr13_+_49063750 3.663 C030044B11Rik
RIKEN cDNA C030044B11 gene
chr1_-_73062445 3.633 NM_009407
Tnp1
transition protein 1
chr11_-_54601093 3.630 Cdc42se2
CDC42 small effector 2
chr8_+_108583449 3.617 NM_010901
Nfatc3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr17_-_29052264 3.617 NM_172450
4930539E08Rik
RIKEN cDNA 4930539E08 gene
chr3_+_30543428 3.589 NM_026668
Lrriq4
leucine-rich repeats and IQ motif containing 4
chr15_-_76500300 3.585 NM_007989
Foxh1
forkhead box H1
chr2_+_59322709 3.565 NM_029723
Dapl1
death associated protein-like 1
chr2_+_158450623 3.544 NM_175419
Actr5
ARP5 actin-related protein 5 homolog (yeast)
chr5_+_136293975 3.524 NM_021403
Srrm3
serine/arginine repetitive matrix 3
chr9_-_71011053 3.487 NM_022026
Aqp9
aquaporin 9
chr9_+_98197001 3.476 NM_144533
Nmnat3
nicotinamide nucleotide adenylyltransferase 3
chr7_-_127813763 3.470 NM_001040137
NM_001040136
Pdzd9

PDZ domain containing 9

chr15_-_102993757 3.462 Smug1
single-strand selective monofunctional uracil DNA glycosylase
chr6_+_41488583 3.459


chr9_+_114976396 3.450 NM_148958
Osbpl10
oxysterol binding protein-like 10
chr16_+_21794392 3.433 1300002E11Rik
RIKEN cDNA 1300002E11 gene
chr2_+_104430617 3.407 NM_001037326
NM_145529
NM_177253
Cstf3


cleavage stimulation factor, 3' pre-RNA, subunit 3


chr19_+_11592938 3.406 NM_027209
Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr9_+_72122785 3.399 Zfp280d
zinc finger protein 280D
chr5_-_138596915 3.398 NM_019747
Zfp113
zinc finger protein 113
chr7_+_130267661 3.393 Tnrc6a
trinucleotide repeat containing 6a
chr4_-_147183894 3.384 NM_001127189
Gm13157
2610036A22Rik
predicted gene 13157
RIKEN cDNA 2610036A22 gene
chr11_-_53520771 3.383 Rad50
RAD50 homolog (S. cerevisiae)
chr14_-_52780511 3.376 Supt16h
suppressor of Ty 16 homolog (S. cerevisiae)
chr11_-_54601163 3.372 NM_178626
Cdc42se2
CDC42 small effector 2
chrY_-_133778 3.345 NM_009570
Zfy1
zinc finger protein 1, Y linked
chr1_-_196957694 3.336 NM_013499
Cr1l
complement component (3b/4b) receptor 1-like
chr3_-_94240497 3.316 NM_016901
Oaz3
ornithine decarboxylase antizyme 3
chr6_+_90288207 3.291 Uroc1
urocanase domain containing 1
chr7_-_55237665 3.291 NM_153524
Mrgpra4
MAS-related GPR, member A4
chr6_+_54839147 3.290 Znrf2
zinc and ring finger 2
chr10_-_127188724 3.283 Gpr182
G protein-coupled receptor 182
chr17_+_36131397 3.283 A930015D03Rik
RIKEN cDNA A930015D03 gene
chr2_-_91019477 3.272 NM_001177720
Madd
MAP-kinase activating death domain
chr8_+_3515373 3.254 NM_001122818
NM_015801
Pnpla6

patatin-like phospholipase domain containing 6

chr7_+_134072351 3.250 NM_172747
Kctd13
potassium channel tetramerisation domain containing 13
chr2_-_169968174 3.228 NM_001159683
Zfp217
zinc finger protein 217
chr13_-_4278605 3.222 NM_013777
Akr1c12
aldo-keto reductase family 1, member C12
chr3_-_102586596 3.215 NM_001165939
NM_001165940
NM_009432
Tshb


thyroid stimulating hormone, beta subunit


chr5_-_21290971 3.206 NM_009584
Dnajc2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr9_-_106378494 3.187 Parp3
poly (ADP-ribose) polymerase family, member 3
chr14_-_56704033 3.175 NM_008572
Mcpt8
mast cell protease 8
chr7_-_30691111 3.162 NM_001037707
NM_011754
Zfp27

zinc finger protein 27

chr11_-_51807636 3.144 5430406J06Rik
RIKEN cDNA 5430406J06 gene
chr1_-_56694278 3.108 NM_027661
Hsfy2
heat shock transcription factor, Y linked 2
chr6_-_129610573 3.081 NM_010653
NM_001098669
Klrc2

killer cell lectin-like receptor subfamily C, member 2

chr2_-_32942666 3.076 NM_178888
Garnl3
GTPase activating RANGAP domain-like 3
chr13_+_120251565 3.069 NM_001113550
NM_026127
4833420G17Rik

RIKEN cDNA 4833420G17 gene

chr1_-_53353810 3.050 NM_153556
Pms1
postmeiotic segregation increased 1 (S. cerevisiae)
chr18_+_74433418 3.041 Mbd1
methyl-CpG binding domain protein 1
chr8_-_47209499 3.040 NM_207213
Snx25
sorting nexin 25
chr6_+_146798631 3.006 NM_027059
1700023A16Rik
RIKEN cDNA 1700023A16 gene
chr2_+_119722957 2.980 NM_001164274
NM_013720
Mga

MAX gene associated

chr7_+_17545027 2.960 NM_001007569
Pnmal1
PNMA-like 1
chr2_+_103909961 2.954 Cd59b
CD59b antigen
chr5_+_135058559 2.933 NM_020022
Rfc2
replication factor C (activator 1) 2
chr10_+_89207730 2.933 NM_029166
Uhrf1bp1l
UHRF1 (ICBP90) binding protein 1-like
chr15_-_72926936 2.913 1110029L17Rik
RIKEN cDNA 1110029L17 gene
chr17_-_5440223 2.911 NM_027457
5730437N04Rik
RIKEN cDNA 5730437N04 gene
chr9_+_77765170 2.902 NM_134255
Elovl5
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chrX_-_92673432 2.893 NM_080858
Asb12
ankyrin repeat and SOCS box-containing 12
chr16_-_89974943 2.870 NM_001145886
Tiam1
T-cell lymphoma invasion and metastasis 1
chrX_+_162608411 2.869 NM_146238
Gemin8
gem (nuclear organelle) associated protein 8
chr12_+_85758140 2.869 NM_025525
Rnf113a2
ring finger protein 113A2
chr12_-_88784769 2.863 NM_001102565
NM_001013372
Alkbh1
Nrp
alkB, alkylation repair homolog 1 (E. coli)
neural regeneration protein
chr6_-_114871769 2.849 NM_177683
Vgll4
vestigial like 4 (Drosophila)
chr16_-_94509462 2.839 NM_139145
Hlcs
holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
chr7_-_53435334 2.837 NM_011510
Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr4_-_109203808 2.834 NM_026291
4930522H14Rik
RIKEN cDNA 4930522H14 gene
chr19_-_10813341 2.820 NM_007650
Cd5
CD5 antigen
chr5_+_137169015 2.811 NM_021611
Myl10
myosin, light chain 10, regulatory
chr6_-_35258102 2.792 NM_172892
Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr6_-_122692754 2.788 NM_011401
Slc2a3
solute carrier family 2 (facilitated glucose transporter), member 3
chr7_-_36103433 2.771 NM_026181
Gpatch1
G patch domain containing 1
chr6_-_127076410 2.767 Ccnd2
cyclin D2
chr3_-_36589048 2.746 NM_019510
Trpc3
transient receptor potential cation channel, subfamily C, member 3
chr12_-_77470450 2.740 NM_001172104
NM_028356
Zbtb25

zinc finger and BTB domain containing 25

chr11_-_78020699 2.740


chr17_-_65890082 2.726 NM_001008973
Tmem232
transmembrane protein 232
chr5_+_130505154 2.724 NM_007761
Crcp
calcitonin gene-related peptide-receptor component protein
chr17_+_34734773 2.719 NM_007425
Ager
advanced glycosylation end product-specific receptor
chr2_-_164653995 2.710 NM_029370
1700020C07Rik
RIKEN cDNA 1700020C07 gene
chr5_-_124804538 2.690 Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr2_-_52532100 2.675 NM_001037099
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
chr17_+_56909672 2.674 NM_001195673
Prr22
proline rich 22
chr2_-_35973217 2.674


chr7_+_126705221 2.669 NM_001177978
NM_146197
Acsm2

acyl-CoA synthetase medium-chain family member 2

chr11_-_100683830 2.650 NM_011489
Stat5b
signal transducer and activator of transcription 5B
chr7_-_19751441 2.650 NM_001080815
Gipr
gastric inhibitory polypeptide receptor
chr9_-_78290953 2.646 NM_173386
E330016A19Rik
RIKEN cDNA E330016A19 gene
chr15_-_78893275 2.632 NM_144849
Ankrd54
ankyrin repeat domain 54
chr5_-_21290925 2.629 Dnajc2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr10_-_74495269 2.620 NM_001163534
NM_001163535
NM_001163533
NM_027730
Rtdr1



rhabdoid tumor deletion region gene 1



chr9_-_105999021 2.618 NM_026763
Col6a4
collagen, type VI, alpha 4
chr9_-_53475610 2.612 NM_001161618
NM_027807
Cul5

cullin 5

chr6_-_130183339 2.607 NM_001110323
Klra7
killer cell lectin-like receptor, subfamily A, member 7
chr1_+_132762248 2.594 Faim3
Fas apoptotic inhibitory molecule 3
chr1_+_78507634 2.585 NM_026713
Mogat1
monoacylglycerol O-acyltransferase 1
chr2_-_165225861 2.578 NM_029021
4833422F24Rik
RIKEN cDNA 4833422F24 gene
chr1_+_132762353 2.577 NM_026976
Faim3
Fas apoptotic inhibitory molecule 3
chr4_+_154243693 2.573 NM_013783
Mmel1
membrane metallo-endopeptidase-like 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.22 1.11e-03 GO:0005634 nucleus
3.37 3.12e-02 GO:0001669 acrosomal vesicle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.32 3.38e-03 GO:0003676 nucleic acid binding
1.12 3.87e-02 GO:0003674 molecular_function