Motif ID: ATF2.p2

Z-value: 2.071


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
Atf2 11909 activating transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2chr2_-_737306050.431.9e-09Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_110779204 66.311 Meg3
maternally expressed 3
chr2_+_136539202 66.236 Snap25
synaptosomal-associated protein 25
chr15_-_83936038 64.236 Sult4a1
sulfotransferase family 4A, member 1
chr2_+_132607398 63.821 Chgb
chromogranin B
chr2_+_132607408 61.591 Chgb
chromogranin B
chr2_+_136539143 61.360 NM_011428
Snap25
synaptosomal-associated protein 25
chr2_+_155102040 55.985 NM_025735
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr8_-_73011217 54.721 NM_182991
Tmem59l
transmembrane protein 59-like
chr1_-_79436564 48.049 NM_009129
Scg2
secretogranin II
chr3_-_117063090 46.131 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr12_+_103793130 46.031 NM_007693
Chga
chromogranin A
chr3_-_117063317 44.610 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chrX_+_162676870 43.606 NM_001177961
NM_001177962
NM_023122
Gpm6b


glycoprotein m6b


chrX_+_162676903 41.530 Gpm6b
glycoprotein m6b
chr2_+_132607432 41.309 Chgb
chromogranin B
chr1_-_166368439 40.850 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr4_+_84851330 40.664 NM_019535
Sh3gl2
SH3-domain GRB2-like 2
chr14_+_66963139 38.303 NM_019675
Stmn4
stathmin-like 4
chr13_-_25361773 36.873 NM_009513
Nrsn1
neurensin 1
chr11_-_90252208 34.715 Hlf
hepatic leukemia factor
chr4_-_41720928 34.581 NM_001164045
NM_001048179
NM_001164044
Ccl27a


chemokine (C-C motif) ligand 27A


chr1_+_63319842 33.982 NM_028673
Zdbf2
zinc finger, DBF-type containing 2
chr2_+_177876635 33.289 NM_028806
Phactr3
phosphatase and actin regulator 3
chr7_-_6683113 32.613 NM_008817
Peg3
paternally expressed 3
chr10_+_69388242 32.471 NM_009670
NM_170687
Ank3

ankyrin 3, epithelial

chr5_+_67067359 30.469 NM_011670
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr2_+_143371807 29.506 NM_008792
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr9_-_97933599 28.848 Clstn2
calsyntenin 2
chr4_-_75779379 27.815 NM_001014288
Ptprd
protein tyrosine phosphatase, receptor type, D
chr18_-_25637786 27.815 Celf4
CUGBP, Elav-like family member 4
chr6_-_92431385 27.770 NM_001134460
Prickle2
prickle homolog 2 (Drosophila)
chr2_+_28048511 27.473 Olfm1
olfactomedin 1
chr7_-_88851823 27.009 Homer2
homer homolog 2 (Drosophila)
chr1_+_75476106 26.755 NM_177056
Tmem198
transmembrane protein 198
chr5_+_25265761 26.476 NM_001004365
Actr3b
ARP3 actin-related protein 3 homolog B (yeast)
chr10_+_40657980 26.289 Wasf1
WASP family 1
chr5_+_137506122 25.997 NM_001039385
Vgf
VGF nerve growth factor inducible
chr17_+_43938789 25.987 NM_207649
Rcan2
regulator of calcineurin 2
chr10_+_59569052 25.919 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr19_-_38199291 25.786 NM_011255
Rbp4
retinol binding protein 4, plasma
chr15_+_34167908 25.565 Laptm4b
lysosomal-associated protein transmembrane 4B
chr16_-_4790212 25.442 5730403B10Rik
RIKEN cDNA 5730403B10 gene
chr17_+_37187550 24.094 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chrX_+_162782484 23.974 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
Gpm6b





glycoprotein m6b





chr15_-_37389073 23.948 NM_001170867
NM_001170868
Ncald

neurocalcin delta

chr15_+_68758773 23.817 NM_010158
Khdrbs3
KH domain containing, RNA binding, signal transduction associated 3
chr19_+_38339167 23.797 NM_020278
Lgi1
leucine-rich repeat LGI family, member 1
chr17_+_44090222 23.753 Rcan2
regulator of calcineurin 2
chr2_+_131735663 23.262 NM_011170
Prnp
prion protein
chr4_+_84851440 22.999 Sh3gl2
SH3-domain GRB2-like 2
chr4_-_154719714 22.979 Prkcz
protein kinase C, zeta
chr16_-_23890909 22.774 NM_009215
Sst
somatostatin
chr4_-_154719834 22.689 NM_001039079
Prkcz
protein kinase C, zeta
chr12_+_118896501 22.626 Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr2_+_135883662 22.333 NM_029530
6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr2_+_28048779 22.328 Olfm1
olfactomedin 1
chr17_+_44090139 22.296 NM_030598
Rcan2
regulator of calcineurin 2
chr7_+_137836057 22.074 NM_021314
Tacc2
transforming, acidic coiled-coil containing protein 2
chr7_+_137836116 21.971 Tacc2
transforming, acidic coiled-coil containing protein 2
chr10_+_20672352 21.844 NM_026203
Ahi1
Abelson helper integration site 1
chr15_+_78744862 21.449 Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr12_+_4082573 21.314 NM_153082
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr19_-_38199036 21.223 Rbp4
retinol binding protein 4, plasma
chr1_-_82232392 21.126 Irs1
insulin receptor substrate 1
chr18_+_37089837 21.079 NM_054072
Pcdha1
protocadherin alpha 1
chr9_-_97933533 21.036 NM_022319
Clstn2
calsyntenin 2
chr17_-_46624611 20.751 NM_001162864
Ttbk1
tau tubulin kinase 1
chr2_-_68310324 20.742 Stk39
serine/threonine kinase 39, STE20/SPS1 homolog (yeast)
chr7_+_137836279 20.443 Tacc2
transforming, acidic coiled-coil containing protein 2
chr18_+_36508277 20.441 NM_001081365
0610010O12Rik
RIKEN cDNA 0610010O12 gene
chr3_+_82162091 19.937 Mtap9
microtubule-associated protein 9
chr8_+_125935441 19.814 NM_023279
Tubb3
tubulin, beta 3
chr10_+_4978808 19.759 Syne1
synaptic nuclear envelope 1
chr11_-_90252228 19.629 NM_172563
Hlf
hepatic leukemia factor
chr5_-_75073816 19.460 NM_001159578
NM_001159579
NM_001159580
NM_010727
Lnx1



ligand of numb-protein X 1



chr3_-_80606500 19.320 Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr3_+_82161952 19.213 NM_001081230
Mtap9
microtubule-associated protein 9
chr11_+_101526871 19.205 Arl4d
ADP-ribosylation factor-like 4D
chr15_-_8660729 19.196 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_155207542 19.051 Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr7_+_69493148 18.936 NM_010882
Ndn
necdin
chr19_+_23215704 18.719 NM_010638
Klf9
Kruppel-like factor 9
chr4_-_109959185 18.699 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_+_101526837 18.388 NM_025404
Arl4d
ADP-ribosylation factor-like 4D
chr15_+_34167780 18.339 NM_033521
Laptm4b
lysosomal-associated protein transmembrane 4B
chr9_-_50576208 18.336 NM_023483
1110032A03Rik
RIKEN cDNA 1110032A03 gene
chr13_-_34222209 18.179 NM_023716
Tubb2b
tubulin, beta 2B
chr14_+_76904316 17.877 NM_009366
Tsc22d1
TSC22 domain family, member 1
chr12_+_72932132 17.800 Daam1
dishevelled associated activator of morphogenesis 1
chr1_-_75476031 17.691 NM_001001565
NM_001001566
Chpf

chondroitin polymerizing factor

chr2_+_28048592 17.686 NM_001038613
NM_001038614
Olfm1

olfactomedin 1

chr7_-_88851798 17.629 NM_001164086
NM_011983
Homer2

homer homolog 2 (Drosophila)

chr11_+_68505416 17.616 NM_175260
Myh10
myosin, heavy polypeptide 10, non-muscle
chr15_+_18750083 17.515 NM_009865
Cdh10
cadherin 10
chr15_-_8660442 17.392 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_102254699 17.388 NM_016759
Rundc3a
RUN domain containing 3A
chr16_-_84955086 17.360 App
amyloid beta (A4) precursor protein
chr19_-_38199267 17.340 Rbp4
retinol binding protein 4, plasma
chr5_+_102194126 17.302 NM_173370
Cds1
CDP-diacylglycerol synthase 1
chr13_+_94073701 17.101 Homer1
homer homolog 1 (Drosophila)
chr4_-_109959366 17.099 NM_001163399
NM_010488
Elavl4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr4_+_138012860 17.058 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_+_28931448 17.000 NM_001162537
9330159F19Rik
RIKEN cDNA 9330159F19 gene
chr5_+_90889937 16.946 Alb
albumin
chr11_+_102254816 16.933 Rundc3a
RUN domain containing 3A
chr6_+_133055256 16.858 NM_001163445
2700089E24Rik
RIKEN cDNA 2700089E24 gene
chr15_-_8660462 16.638 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_177876858 16.609 Phactr3
phosphatase and actin regulator 3
chr17_+_44090341 16.534 Rcan2
regulator of calcineurin 2
chr8_-_67071497 16.513


chr2_+_177876710 16.311 Phactr3
phosphatase and actin regulator 3
chr12_+_4082739 16.205 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr17_+_44090192 16.021 Rcan2
regulator of calcineurin 2
chr3_+_67868723 15.998 NM_001113420
NM_001113421
Schip1

schwannomin interacting protein 1

chr8_+_125935470 15.869 Tubb3
tubulin, beta 3
chr19_-_38199737 15.767 NM_001159487
Rbp4
retinol binding protein 4, plasma
chrX_-_20498021 15.752 NM_001110780
NM_013680
Syn1

synapsin I

chr1_+_12708582 15.589 NM_172294
Sulf1
sulfatase 1
chr4_+_101180625 15.538 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr15_+_81767188 15.287 NM_145473
Csdc2
cold shock domain containing C2, RNA binding
chr17_-_56615861 15.201 Ptprs
protein tyrosine phosphatase, receptor type, S
chr15_-_8660479 15.030 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_149280946 14.998 Dusp8
dual specificity phosphatase 8
chr13_-_100286521 14.584 NM_008634
Mtap1b
microtubule-associated protein 1B
chr18_+_40416615 14.443 2900055J20Rik
RIKEN cDNA 2900055J20 gene
chr10_+_59569206 14.405 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr10_-_67375130 14.225 Zfp365
zinc finger protein 365
chr8_-_42127124 14.162 Mtus1
mitochondrial tumor suppressor 1
chr9_-_91255831 14.160 Zic1
zinc finger protein of the cerebellum 1
chr19_+_23216035 14.143 Klf9
Kruppel-like factor 9
chr5_-_51945054 14.067 NM_008904
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr1_-_94998418 13.935 NM_001110315
NM_008440
Kif1a

kinesin family member 1A

chr11_+_102254949 13.808 Rundc3a
RUN domain containing 3A
chr9_+_69137694 13.733 Rora
RAR-related orphan receptor alpha
chr12_-_103981869 13.645 NM_001142937
NM_022323
Moap1

modulator of apoptosis 1

chr2_+_26171051 13.638 NM_153410
Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr1_-_93355893 13.541 NM_011066
Per2
period homolog 2 (Drosophila)
chr2_-_66278870 13.527 NM_018733
Scn1a
sodium channel, voltage-gated, type I, alpha
chr3_+_82162037 13.504 Mtap9
microtubule-associated protein 9
chr2_-_25325248 13.430 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr1_-_132625829 13.422 NM_001162415
Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr18_-_24688688 13.349 NM_144861
Rprd1a
regulation of nuclear pre-mRNA domain containing 1A
chr18_+_37880036 13.302 NM_033576
Pcdhgb4
protocadherin gamma subfamily B, 4
chr5_+_90889913 13.299 NM_009654
Alb
albumin
chr2_+_61884596 13.296 NM_033552
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr8_-_48373564 12.990 Stox2
storkhead box 2
chr6_+_124881437 12.899 Mlf2
myeloid leukemia factor 2
chr2_+_49474775 12.888 NM_008449
Kif5c
kinesin family member 5C
chr8_-_73987384 12.833 NM_022419
Abhd8
abhydrolase domain containing 8
chr2_+_26171073 12.793 Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr6_+_129483215 12.757 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr1_-_71699671 12.700 NM_010233
Fn1
fibronectin 1
chr6_+_129483238 12.691 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr6_+_54631644 12.627 NM_026629
2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr1_-_94998392 12.595 Kif1a
kinesin family member 1A
chr1_-_93355838 12.516 Per2
period homolog 2 (Drosophila)
chr4_-_76240202 12.462 NM_011211
Ptprd
protein tyrosine phosphatase, receptor type, D
chr5_-_103640272 12.461 NM_001081567
NM_009158
Mapk10

mitogen-activated protein kinase 10

chr17_+_43938887 12.424 Rcan2
regulator of calcineurin 2
chr6_-_124414668 12.251 NM_153508
Clstn3
calsyntenin 3
chr5_+_102194207 12.217 Cds1
CDP-diacylglycerol synthase 1
chr5_+_135526788 12.217


chr14_+_102239673 12.091 Lmo7
LIM domain only 7
chr19_-_6235784 12.056 NM_198168
Ppp2r5b
protein phosphatase 2, regulatory subunit B (B56), beta isoform
chr9_+_43893029 12.024 Usp2
ubiquitin specific peptidase 2
chr1_-_36766756 11.978 NM_146107
Actr1b
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr13_-_100286446 11.970 Mtap1b
microtubule-associated protein 1B
chr6_+_124881376 11.946 NM_001170341
NM_145385
Mlf2

myeloid leukemia factor 2

chr9_+_43942734 11.921 NM_023061
Mcam
melanoma cell adhesion molecule
chr8_-_93657840 11.893 Aktip
thymoma viral proto-oncogene 1 interacting protein
chr15_+_74346853 11.638 Bai1
brain-specific angiogenesis inhibitor 1
chrX_-_49033575 11.608 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr12_+_53800369 11.556 NM_198111
Akap6
A kinase (PRKA) anchor protein 6
chr8_-_25549374 11.550 1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr5_+_19413335 11.511 NM_001170745
NM_015823
Magi2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr5_-_37087142 11.448 D5Ertd579e
DNA segment, Chr 5, ERATO Doi 579, expressed
chr17_+_25945986 11.257 NM_001164225
Fbxl16
F-box and leucine-rich repeat protein 16
chr8_-_95721654 11.212 Ces1d
carboxylesterase 1D
chr10_+_97028134 11.030 NM_008524
Lum
lumican
chr4_-_134409199 10.984 Tmem57
transmembrane protein 57
chr10_-_67375332 10.970 NM_178679
Zfp365
zinc finger protein 365
chr5_-_148537561 10.963 NM_010228
Flt1
FMS-like tyrosine kinase 1
chr1_-_33964439 10.929 NM_177235
Bend6
BEN domain containing 6
chr2_-_102291924 10.922 NM_010218
Fjx1
four jointed box 1 (Drosophila)
chrX_-_45245608 10.800 NM_053123
Smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr5_-_52957466 10.724 Lgi2
leucine-rich repeat LGI family, member 2
chr18_+_45719101 10.717 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr8_-_25549415 10.705 NM_026931
1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr6_+_124881472 10.700 Mlf2
myeloid leukemia factor 2
chr9_-_52487410 10.673 NM_178906
AI593442
expressed sequence AI593442
chr8_+_23868194 10.621 NM_008872
Plat
plasminogen activator, tissue
chr17_-_49703661 10.606 NM_001008231
Daam2
dishevelled associated activator of morphogenesis 2
chr13_-_54712629 10.582 NM_028870
Cltb
clathrin, light polypeptide (Lcb)
chr9_-_62384483 10.517 Coro2b
coronin, actin binding protein, 2B
chr14_+_60997104 10.487 NM_001164705
NM_028113
Fam123a

family with sequence similarity 123, member A

chr9_-_45743950 10.444 Tagln
transgelin
chr8_-_42127242 10.402 NM_001005865
Mtus1
mitochondrial tumor suppressor 1
chr18_-_35374531 10.377 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr6_+_129483206 10.360 NM_020590
Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr9_+_66561492 10.291 NM_178396
Car12
carbonic anyhydrase 12

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.76 4.41e-04 GO:0007399 nervous system development
1.86 2.87e-03 GO:0022008 neurogenesis
1.42 1.93e-02 GO:0048731 system development
1.80 2.56e-02 GO:0048699 generation of neurons
1.37 5.00e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.28 1.51e-08 GO:0005737 cytoplasm
1.88 9.09e-07 GO:0000267 cell fraction
1.18 2.53e-06 GO:0005622 intracellular
2.36 7.29e-06 GO:0045202 synapse
1.17 1.70e-05 GO:0044424 intracellular part
1.91 2.22e-05 GO:0005626 insoluble fraction
2.20 2.23e-05 GO:0043005 neuron projection
2.57 6.91e-05 GO:0043025 neuronal cell body
2.52 8.01e-05 GO:0044297 cell body
2.74 1.17e-04 GO:0030424 axon
1.83 3.12e-04 GO:0005624 membrane fraction
2.42 4.36e-04 GO:0044456 synapse part
1.18 6.11e-04 GO:0043229 intracellular organelle
1.17 8.78e-04 GO:0043226 organelle
1.96 9.43e-04 GO:0030054 cell junction
2.13 3.16e-03 GO:0044463 cell projection part
1.24 4.27e-03 GO:0044444 cytoplasmic part
2.34 6.33e-03 GO:0030425 dendrite
1.62 9.38e-03 GO:0042995 cell projection
2.10 2.13e-02 GO:0005625 soluble fraction
2.87 2.71e-02 GO:0019717 synaptosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.38 4.88e-09 GO:0005515 protein binding
1.21 2.08e-08 GO:0005488 binding
10.44 2.68e-02 GO:0043295 glutathione binding
1.88 3.33e-02 GO:0019904 protein domain specific binding