Motif ID: ATF4.p2

Z-value: 2.141


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
Atf4 11911 activating transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4chr15_+_800856130.342.3e-06Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_134875526 38.042 NM_173762
Cenpe
centromere protein E
chr5_-_130478834 36.510 Gusb
glucuronidase, beta
chr14_-_47896531 35.183 NM_172598
Wdhd1
WD repeat and HMG-box DNA binding protein 1
chr3_-_19211000 30.853 NM_001122759
Pde7a
phosphodiesterase 7A
chr17_+_35118956 30.614 NM_030597
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_-_36470904 30.395 NM_009828
Ccna2
cyclin A2
chr3_-_36470845 29.431 Ccna2
cyclin A2
chr1_-_71699671 29.027 NM_010233
Fn1
fibronectin 1
chr12_+_33505307 28.942 Nampt
nicotinamide phosphoribosyltransferase
chr14_-_47896464 28.866 Wdhd1
WD repeat and HMG-box DNA binding protein 1
chr3_-_36470882 28.386 Ccna2
cyclin A2
chr1_-_13650563 27.456 NM_145381
Lactb2
lactamase, beta 2
chr2_+_167514414 26.794 NM_009883
Cebpb
CCAAT/enhancer binding protein (C/EBP), beta
chr12_+_33505364 25.614 Nampt
nicotinamide phosphoribosyltransferase
chr18_+_11815869 25.323 Rbbp8
retinoblastoma binding protein 8
chr9_-_20781206 24.695 NM_010333
S1pr2
sphingosine-1-phosphate receptor 2
chr2_+_167514489 24.062 Cebpb
CCAAT/enhancer binding protein (C/EBP), beta
chr7_+_52973440 23.455 NM_009077
Rpl18
ribosomal protein L18
chr9_-_20781133 23.221 S1pr2
sphingosine-1-phosphate receptor 2
chr2_+_167514460 23.078 Cebpb
CCAAT/enhancer binding protein (C/EBP), beta
chr18_+_11816327 22.757 NM_001081223
Rbbp8
retinoblastoma binding protein 8
chr4_-_133801438 21.524 NM_024215
Zfp593
zinc finger protein 593
chr10_-_111434265 21.297 NM_028608
Glipr1
GLI pathogenesis-related 1 (glioma)
chr2_-_126959605 20.985 NM_144818
Ncaph
non-SMC condensin I complex, subunit H
chr15_+_79177959 20.896 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr4_-_55545211 20.852 Klf4
Kruppel-like factor 4 (gut)
chr8_+_77633426 20.741 NM_008566
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr10_+_85334563 20.370 NM_133993
Pwp1
PWP1 homolog (S. cerevisiae)
chr19_-_4625574 20.298 NM_023131
Rce1
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr4_-_55545337 20.124 NM_010637
Klf4
Kruppel-like factor 4 (gut)
chr16_+_57549340 19.972 NM_001177871
Filip1l
filamin A interacting protein 1-like
chr17_-_74694322 19.786 Memo1
mediator of cell motility 1
chr3_-_107499129 18.994 Ahcyl1
S-adenosylhomocysteine hydrolase-like 1
chr3_-_127256215 18.260 NM_138593
Larp7
La ribonucleoprotein domain family, member 7
chr5_-_130478687 18.064 NM_010368
Gusb
glucuronidase, beta
chr9_-_59334393 18.058 Arih1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr14_-_67691221 17.940 NM_028032
Ppp2r2a
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
chr15_+_61869529 17.906 Pvt1
plasmacytoma variant translocation 1
chr8_+_125000042 17.813 NM_153775
Ctu2
cytosolic thiouridylase subunit 2 homolog (S. pombe)
chr5_-_111082387 17.722 NM_153570
Noc4l
nucleolar complex associated 4 homolog (S. cerevisiae)
chr10_-_111434231 17.620 Glipr1
GLI pathogenesis-related 1 (glioma)
chr18_+_66618186 17.430 NM_021451
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr10_-_92185071 17.292 NM_008682
Nedd1
neural precursor cell expressed, developmentally down-regulated gene 1
chr17_-_71876150 17.281 NM_023294
Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr17_-_71876127 17.133 Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr15_+_79178063 16.943 NM_010755
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr8_+_74659107 16.899 NM_001001491
Tpm4
tropomyosin 4
chr12_-_103213890 16.823 Gm2701
predicted gene 2701
chr6_-_39675456 16.449 NM_139294
Braf
Braf transforming gene
chr8_-_87186691 16.061 NM_010499
Ier2
immediate early response 2
chr10_-_117283020 16.037 NM_024457
Rap1b
RAS related protein 1b
chr3_+_40603872 15.993 NM_011495
Plk4
polo-like kinase 4 (Drosophila)
chr17_+_75404865 15.934 NM_019919
Ltbp1
latent transforming growth factor beta binding protein 1
chr5_-_111082269 15.730 Noc4l
nucleolar complex associated 4 homolog (S. cerevisiae)
chr11_+_83116148 15.526 NM_001035854
NM_027915
Ap2b1

adaptor-related protein complex 2, beta 1 subunit

chr6_-_131243197 15.458 NM_025564
Magohb
mago-nashi homolog B (Drosophila)
chr2_-_132078887 15.453 NM_011045
Pcna
proliferating cell nuclear antigen
chr12_+_117519658 15.400 NM_028731
Esyt2
extended synaptotagmin-like protein 2
chrX_-_53851108 15.250 Mmgt1
membrane magnesium transporter 1
chr11_+_117710532 15.238 NM_001012273
NM_009689
Birc5

baculoviral IAP repeat-containing 5

chr19_-_34549624 15.071 NM_009890
Ch25h
cholesterol 25-hydroxylase
chr19_+_21346734 15.034 NM_009551
Zfand5
zinc finger, AN1-type domain 5
chr17_+_35118792 14.944 NM_001110101
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_-_31449991 14.445 NM_027999
Haus5
HAUS augmin-like complex, subunit 5
chr11_+_83116262 14.338 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr1_-_193007202 14.272 NM_007498
Atf3
activating transcription factor 3
chr17_-_43013320 14.225 NM_009847
Cd2ap
CD2-associated protein
chr17_-_53828596 14.185 NM_028232
Sgol1
shugoshin-like 1 (S. pombe)
chr5_-_152453753 14.014 NM_027009
Rfc3
replication factor C (activator 1) 3
chr5_+_112705715 14.011 NM_009419
Tpst2
protein-tyrosine sulfotransferase 2
chr11_-_77978936 14.010 NM_009423
Traf4
TNF receptor associated factor 4
chr3_+_137806411 13.959 NM_175389
Rg9mtd2
RNA (guanine-9-) methyltransferase domain containing 2
chr1_-_51535232 13.829 NM_028696
Obfc2a
oligonucleotide/oligosaccharide-binding fold containing 2A
chr11_+_76057230 13.767 NM_183263
Rnmtl1
RNA methyltransferase like 1
chr13_-_22134795 13.665 NM_178186
Hist1h2ag
Hist1h2ai
histone cluster 1, H2ag
histone cluster 1, H2ai
chr9_-_75257067 13.508 NM_027418
Mapk6
mitogen-activated protein kinase 6
chr10_-_117282901 13.480 Rap1b
RAS related protein 1b
chr16_+_24393435 13.343 NM_178665
Lpp
LIM domain containing preferred translocation partner in lipoma
chr8_+_131209614 13.242 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr17_-_34324234 13.169 NM_013585
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr17_-_35089399 13.053 1110038B12Rik
RIKEN cDNA 1110038B12 gene
chr14_-_69903072 12.995 NM_026331
Slc25a37
solute carrier family 25, member 37
chr7_+_25689359 12.935 NM_001130152
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr1_-_193006986 12.924 Atf3
activating transcription factor 3
chr2_-_132078946 12.757 Pcna
proliferating cell nuclear antigen
chrX_-_53851046 12.744 NM_146234
Mmgt1
membrane magnesium transporter 1
chr7_-_26035683 12.727 NM_010155
Erf
Ets2 repressor factor
chr7_-_31449951 12.659 Haus5
HAUS augmin-like complex, subunit 5
chr11_-_76057153 12.618 Glod4
glyoxalase domain containing 4
chr2_+_109120894 12.536 NM_139303
Kif18a
kinesin family member 18A
chr5_-_136410216 12.530 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr7_-_52781502 12.526 NM_008654
Ppp1r15a
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr4_+_140857147 12.524 NM_010139
Epha2
Eph receptor A2
chr16_-_4077714 12.490 NM_026508
Trap1
TNF receptor-associated protein 1
chr19_+_6085096 12.479 NM_026410
Cdca5
cell division cycle associated 5
chr9_-_4309324 12.369 Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr6_+_146591082 12.313 NM_025315
Med21
mediator complex subunit 21
chr2_-_119980243 12.270 NM_133838
Ehd4
EH-domain containing 4
chr19_+_7568529 12.221 NM_001163505
Atl3
atlastin GTPase 3
chr9_+_108462759 12.152 NM_011830
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr8_-_82235601 12.028 NM_015751
Abce1
ATP-binding cassette, sub-family E (OABP), member 1
chr2_-_119980210 11.986 Ehd4
EH-domain containing 4
chr17_+_75404893 11.958 Ltbp1
latent transforming growth factor beta binding protein 1
chrX_+_71558358 11.913 NM_138607
Fam50a
family with sequence similarity 50, member A
chr5_+_35104416 11.888 Htt
huntingtin
chr3_-_127256181 11.720 Larp7
La ribonucleoprotein domain family, member 7
chr2_+_164571458 11.660 NM_133763
Dnttip1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr17_-_74694120 11.556 NM_133771
Memo1
mediator of cell motility 1
chr7_+_25689409 11.465 Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr18_-_52688607 11.448 Lox
lysyl oxidase
chr10_-_17667872 11.413 NM_001033432
Heca
headcase homolog (Drosophila)
chr9_+_108957402 11.401 NM_026381
Shisa5
shisa homolog 5 (Xenopus laevis)
chr17_-_26206487 11.255 Rab11fip3
RAB11 family interacting protein 3 (class II)
chr5_+_123526279 11.125 NM_001039723
Tmem120b
transmembrane protein 120B
chr8_+_119445639 11.077 NM_028131
Cenpn
centromere protein N
chr19_+_6057884 11.043 NM_001160239
NM_007990
NM_001190436
Fau


Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)


chr8_+_131209680 11.026 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr7_+_28954717 11.026 NM_007991
Fbl
fibrillarin
chr2_+_156665812 11.004 NM_173396
Tgif2
TGFB-induced factor homeobox 2
chr2_-_179777080 10.915 NM_011969
Psma7
proteasome (prosome, macropain) subunit, alpha type 7
chr8_-_108535317 10.875 NM_028038
Ddx28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr3_+_95462640 10.713 NM_008562
Mcl1
myeloid cell leukemia sequence 1
chr3_+_95462705 10.577 Mcl1
myeloid cell leukemia sequence 1
chr6_+_87863915 10.522 NM_173737
8430410A17Rik
RIKEN cDNA 8430410A17 gene
chr9_-_44152208 10.402 Hmbs
hydroxymethylbilane synthase
chr11_-_69485842 10.388 NM_001159375
NM_144958
Eif4a1

eukaryotic translation initiation factor 4A1

chr3_-_143868210 10.372 NM_010723
Lmo4
LIM domain only 4
chr16_-_33967064 10.358 NM_009471
Umps
uridine monophosphate synthetase
chr7_-_20214596 10.333 NM_009046
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr7_-_72017803 10.331 NM_023239
Ndnl2
necdin-like 2
chr2_+_118872854 10.294 NM_029617
Casc5
cancer susceptibility candidate 5
chr3_+_30993952 10.284 NM_001039090
NM_011386
Skil

SKI-like

chr6_+_140572056 10.241 NM_001005605
Aebp2
AE binding protein 2
chr8_+_131209787 10.153 Itgb1
integrin beta 1 (fibronectin receptor beta)
chr2_+_32631305 10.103 NM_178595
Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr5_-_4104331 10.068 Cyp51
cytochrome P450, family 51
chr17_+_15841889 10.042 NM_007690
Chd1
chromodomain helicase DNA binding protein 1
chrX_-_35917684 10.026 Cul4b
cullin 4B
chr3_-_143868114 10.026 Lmo4
LIM domain only 4
chr7_-_126864266 9.990 NM_145585
Thumpd1
THUMP domain containing 1
chr4_+_129784799 9.985 NM_026441
Pef1
penta-EF hand domain containing 1
chr15_+_100058249 9.945 NM_007497
Atf1
activating transcription factor 1
chr9_-_119231439 9.906 Oxsr1
oxidative-stress responsive 1
chr11_-_69485800 9.882 Eif4a1
eukaryotic translation initiation factor 4A1
chr11_-_70051081 9.874


chr1_+_137625754 9.871 NM_007791
Csrp1
cysteine and glycine-rich protein 1
chr5_+_33361386 9.829 NM_011738
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr19_-_61304260 9.817 NM_009970
Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr11_-_76057188 9.796 NM_026029
Glod4
glyoxalase domain containing 4
chr17_-_57150821 9.779 Gtf2f1
general transcription factor IIF, polypeptide 1
chr15_+_65618577 9.765 NM_133766
Efr3a
EFR3 homolog A (S. cerevisiae)
chr17_+_34324636 9.735 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_+_111082466 9.728 NM_027156
Ddx51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr7_+_3655919 9.685 Rps9
ribosomal protein S9
chr14_-_47809063 9.516 NM_008102
Gch1
GTP cyclohydrolase 1
chr3_-_108643390 9.482 NM_011504
Stxbp3a
Stxbp3b
syntaxin binding protein 3A
syntaxin-binding protein 3B
chr16_-_57606866 9.438 NM_025599
2610528E23Rik
RIKEN cDNA 2610528E23 gene
chr8_-_4779533 9.426 NM_011369
Shcbp1
Shc SH2-domain binding protein 1
chr8_-_41596638 9.398 NM_011135
Cnot7
CCR4-NOT transcription complex, subunit 7
chrX_+_151696991 9.395 NM_019736
Acot9
acyl-CoA thioesterase 9
chr5_+_3343861 9.375 Cdk6
cyclin-dependent kinase 6
chr10_+_96079634 9.363 NM_007569
Btg1
B-cell translocation gene 1, anti-proliferative
chr11_-_106117095 9.350 NM_025310
Ftsj3
FtsJ homolog 3 (E. coli)
chr17_+_23816331 9.158 NM_018777
Cldn6
claudin 6
chr19_+_37450854 9.157 NM_010615
Kif11
kinesin family member 11
chr7_+_54101157 9.104 NM_010699
Ldha
lactate dehydrogenase A
chr9_-_44152242 9.093 NM_013551
Hmbs
hydroxymethylbilane synthase
chr12_+_70473032 9.062 NM_007481
Arf6
ADP-ribosylation factor 6
chr5_+_143722032 9.010 NM_007984
Fscn1
fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
chr4_+_126354857 8.969 NM_011970
Psmb2
proteasome (prosome, macropain) subunit, beta type 2
chr14_+_47896669 8.923 NM_080843
Socs4
suppressor of cytokine signaling 4
chr5_-_4104696 8.909 NM_020010
Cyp51
cytochrome P450, family 51
chr2_-_23011403 8.856 NM_025979
Mastl
microtubule associated serine/threonine kinase-like
chr5_+_151325197 8.818 NM_009765
NM_001081001
Brca2

breast cancer 2

chr15_-_20596495 8.777 NM_022816
Acot10
acyl-CoA thioesterase 10
chr19_-_6057706 8.761 NM_026246
Mrpl49
mitochondrial ribosomal protein L49
chr19_+_37000568 8.750 NM_001080706
Btaf1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, (Mot1 homolog, S. cerevisiae)
chr3_-_127256114 8.749 Larp7
La ribonucleoprotein domain family, member 7
chr17_+_34324700 8.709 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_-_75322941 8.639 NM_010798
Mif
macrophage migration inhibitory factor
chr17_-_26206459 8.592 Rab11fip3
RAB11 family interacting protein 3 (class II)
chr13_+_111185251 8.442 NM_152804
Plk2
polo-like kinase 2 (Drosophila)
chr6_-_148893155 8.413 Fam60a
family with sequence similarity 60, member A
chr9_+_113650560 8.391 NM_001114347
Clasp2
CLIP associating protein 2
chr1_+_95375503 8.360 NM_001159717
NM_001159718
NM_010891
NM_001159719
Sept2



septin 2



chr1_-_193399412 8.326 NM_029766
Dtl
denticleless homolog (Drosophila)
chr5_+_125029125 8.309 NM_181410
Gtf2h3
general transcription factor IIH, polypeptide 3
chr2_+_146838735 8.292 NM_011917
Xrn2
5'-3' exoribonuclease 2
chr7_+_3655602 8.292 NM_029767
Rps9
ribosomal protein S9
chr8_-_72149070 8.288 NM_001045553
Zfp868
zinc finger protein 868
chr6_+_120786323 8.281 Bcl2l13
BCL2-like 13 (apoptosis facilitator)
chr10_+_82092582 8.247 NM_011561
NM_172552
Tdg

Gm9855
thymine DNA glycosylase

thymine DNA glycosylase pseudogene
chr9_-_97011440 8.240 NM_138756
Slc25a36
solute carrier family 25, member 36
chr8_-_72498125 8.205 Gatad2a
GATA zinc finger domain containing 2A
chr4_-_136913576 8.204 NM_009861
Cdc42
cell division cycle 42 homolog (S. cerevisiae)
chr19_-_4625276 8.164 Rce1
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr1_-_167167019 8.160 NM_145513
Tiprl
TIP41, TOR signalling pathway regulator-like (S. cerevisiae)
chr1_-_95698465 8.156 NM_001105667
NM_023136
Dtymk

deoxythymidylate kinase

chr10_-_119638448 8.127 NM_028679
Irak3
interleukin-1 receptor-associated kinase 3
chr12_-_74387687 8.106 NM_029580
Trmt5
TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.81 7.01e-34 GO:0044260 cellular macromolecule metabolic process
1.64 3.36e-33 GO:0044237 cellular metabolic process
1.62 3.63e-32 GO:0044238 primary metabolic process
1.71 1.66e-30 GO:0043170 macromolecule metabolic process
1.51 5.95e-28 GO:0008152 metabolic process
1.98 9.00e-24 GO:0090304 nucleic acid metabolic process
1.88 1.19e-23 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.78 2.22e-21 GO:0034641 cellular nitrogen compound metabolic process
1.76 2.90e-21 GO:0006807 nitrogen compound metabolic process
1.94 2.65e-20 GO:0010467 gene expression
1.89 3.52e-16 GO:0016070 RNA metabolic process
1.79 3.07e-13 GO:0009059 macromolecule biosynthetic process
1.78 5.64e-13 GO:0034645 cellular macromolecule biosynthetic process
1.22 1.26e-12 GO:0009987 cellular process
1.66 1.58e-12 GO:0044249 cellular biosynthetic process
1.80 4.69e-12 GO:0044267 cellular protein metabolic process
1.63 6.39e-12 GO:0009058 biosynthetic process
2.80 2.77e-11 GO:0006396 RNA processing
1.60 1.09e-09 GO:0071840 cellular component organization or biogenesis
1.70 3.11e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.47 5.39e-09 GO:0019222 regulation of metabolic process
1.51 1.08e-08 GO:0031323 regulation of cellular metabolic process
1.61 1.19e-08 GO:0019538 protein metabolic process
1.51 2.20e-08 GO:0060255 regulation of macromolecule metabolic process
1.50 2.69e-08 GO:0080090 regulation of primary metabolic process
2.21 2.85e-08 GO:0007049 cell cycle
1.85 7.15e-08 GO:0006996 organelle organization
1.72 5.45e-07 GO:0006351 transcription, DNA-dependent
1.71 6.15e-07 GO:0032774 RNA biosynthetic process
1.53 6.61e-07 GO:0016043 cellular component organization
1.56 2.11e-06 GO:0048522 positive regulation of cellular process
1.61 2.40e-06 GO:0071842 cellular component organization at cellular level
1.55 2.71e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.54 3.50e-06 GO:0010556 regulation of macromolecule biosynthetic process
1.52 3.74e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 5.00e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.50 6.65e-06 GO:0048518 positive regulation of biological process
1.56 6.87e-06 GO:0006355 regulation of transcription, DNA-dependent
2.59 7.14e-06 GO:0000278 mitotic cell cycle
1.50 1.36e-05 GO:0010468 regulation of gene expression
1.54 1.62e-05 GO:0051252 regulation of RNA metabolic process
3.35 1.98e-05 GO:0034470 ncRNA processing
1.48 2.79e-05 GO:0009889 regulation of biosynthetic process
3.30 2.90e-05 GO:0022613 ribonucleoprotein complex biogenesis
1.48 4.94e-05 GO:0031326 regulation of cellular biosynthetic process
1.74 5.30e-05 GO:0031325 positive regulation of cellular metabolic process
2.43 7.52e-05 GO:0006974 response to DNA damage stimulus
3.76 7.52e-05 GO:0042254 ribosome biogenesis
1.73 7.68e-05 GO:0010604 positive regulation of macromolecule metabolic process
2.95 8.25e-05 GO:0034660 ncRNA metabolic process
3.13 9.66e-05 GO:0071843 cellular component biogenesis at cellular level
2.55 1.10e-04 GO:0051301 cell division
1.68 1.90e-04 GO:0009893 positive regulation of metabolic process
1.59 2.45e-04 GO:0043412 macromolecule modification
2.91 3.04e-04 GO:0010564 regulation of cell cycle process
3.60 3.36e-04 GO:0006366 transcription from RNA polymerase II promoter
2.00 4.99e-04 GO:0033554 cellular response to stress
2.23 5.20e-04 GO:0051726 regulation of cell cycle
2.17 5.99e-04 GO:0006259 DNA metabolic process
2.80 6.79e-04 GO:0000087 M phase of mitotic cell cycle
2.77 1.35e-03 GO:0000280 nuclear division
2.77 1.35e-03 GO:0007067 mitosis
2.50 2.49e-03 GO:0006412 translation
4.36 2.52e-03 GO:0008033 tRNA processing
2.00 2.68e-03 GO:0022402 cell cycle process
2.66 3.12e-03 GO:0048285 organelle fission
1.72 3.37e-03 GO:0051641 cellular localization
12.56 4.24e-03 GO:0051313 attachment of spindle microtubules to chromosome
1.54 4.68e-03 GO:0006464 protein modification process
2.43 4.69e-03 GO:0006281 DNA repair
1.72 5.23e-03 GO:0044085 cellular component biogenesis
3.49 6.94e-03 GO:0006399 tRNA metabolic process
1.74 8.41e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.70 8.72e-03 GO:0043067 regulation of programmed cell death
1.80 9.65e-03 GO:0051254 positive regulation of RNA metabolic process
2.95 1.05e-02 GO:0000226 microtubule cytoskeleton organization
1.70 1.06e-02 GO:0042981 regulation of apoptosis
1.62 1.17e-02 GO:0033036 macromolecule localization
1.80 1.18e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.68 1.22e-02 GO:0010941 regulation of cell death
7.28 1.38e-02 GO:0034453 microtubule anchoring
2.09 1.40e-02 GO:0044265 cellular macromolecule catabolic process
1.69 1.52e-02 GO:0031328 positive regulation of cellular biosynthetic process
3.60 1.58e-02 GO:0006364 rRNA processing
1.68 1.63e-02 GO:0009891 positive regulation of biosynthetic process
5.51 1.67e-02 GO:0031023 microtubule organizing center organization
3.42 1.69e-02 GO:0007059 chromosome segregation
2.07 1.87e-02 GO:0022403 cell cycle phase
1.72 1.88e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.04 1.93e-02 GO:0007010 cytoskeleton organization
1.74 2.02e-02 GO:0051128 regulation of cellular component organization
1.50 2.12e-02 GO:0006950 response to stress
2.37 2.24e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.70 2.28e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
3.49 2.40e-02 GO:0016072 rRNA metabolic process
1.73 2.48e-02 GO:0010628 positive regulation of gene expression
2.25 2.49e-02 GO:0030163 protein catabolic process
2.32 3.48e-02 GO:0019941 modification-dependent protein catabolic process
2.28 3.59e-02 GO:0044257 cellular protein catabolic process
2.30 4.01e-02 GO:0043632 modification-dependent macromolecule catabolic process
2.42 4.33e-02 GO:0007017 microtubule-based process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.47 5.47e-52 GO:0044424 intracellular part
1.46 7.58e-52 GO:0005622 intracellular
1.61 6.69e-50 GO:0043227 membrane-bounded organelle
1.55 1.16e-49 GO:0043226 organelle
1.54 7.32e-49 GO:0043229 intracellular organelle
1.60 1.68e-48 GO:0043231 intracellular membrane-bounded organelle
1.88 1.92e-44 GO:0005634 nucleus
1.42 4.82e-22 GO:0005737 cytoplasm
1.17 1.32e-18 GO:0005623 cell
1.17 1.32e-18 GO:0044464 cell part
1.98 5.82e-15 GO:0044428 nuclear part
1.55 1.77e-13 GO:0044446 intracellular organelle part
1.53 3.85e-13 GO:0044422 organelle part
1.92 2.82e-12 GO:0070013 intracellular organelle lumen
2.00 2.89e-12 GO:0031981 nuclear lumen
1.91 3.29e-12 GO:0043233 organelle lumen
1.90 3.67e-12 GO:0031974 membrane-enclosed lumen
1.58 2.13e-11 GO:0032991 macromolecular complex
1.37 5.34e-09 GO:0044444 cytoplasmic part
1.77 2.10e-07 GO:0005829 cytosol
1.95 2.75e-07 GO:0005654 nucleoplasm
1.55 9.47e-07 GO:0043228 non-membrane-bounded organelle
1.55 9.47e-07 GO:0043232 intracellular non-membrane-bounded organelle
2.31 7.88e-06 GO:0030529 ribonucleoprotein complex
1.47 9.54e-06 GO:0043234 protein complex
2.17 2.40e-04 GO:0005694 chromosome
2.29 3.31e-04 GO:0005730 nucleolus
1.90 6.13e-04 GO:0044451 nucleoplasm part
1.55 1.13e-03 GO:0005739 mitochondrion
3.10 2.16e-03 GO:0000775 chromosome, centromeric region
2.09 2.29e-03 GO:0044427 chromosomal part
4.26 6.17e-03 GO:0000502 proteasome complex
2.60 1.94e-02 GO:0005840 ribosome
4.45 2.04e-02 GO:0022626 cytosolic ribosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.32 2.57e-23 GO:0005488 binding
1.87 8.95e-19 GO:0003676 nucleic acid binding
1.38 3.98e-10 GO:0005515 protein binding
2.38 4.51e-10 GO:0003723 RNA binding
1.80 4.97e-10 GO:0003677 DNA binding
1.37 2.68e-08 GO:0003824 catalytic activity
1.65 4.45e-08 GO:0000166 nucleotide binding
1.66 1.38e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.73 2.11e-06 GO:0005524 ATP binding
1.63 3.39e-06 GO:0017076 purine nucleotide binding
1.71 4.00e-06 GO:0030554 adenyl nucleotide binding
1.63 4.79e-06 GO:0032555 purine ribonucleotide binding
1.63 4.96e-06 GO:0032553 ribonucleotide binding
1.70 5.75e-06 GO:0032559 adenyl ribonucleotide binding
3.76 8.01e-03 GO:0008026 ATP-dependent helicase activity
3.76 8.01e-03 GO:0070035 purine NTP-dependent helicase activity
1.67 8.47e-03 GO:0030528 transcription regulator activity
1.39 1.54e-02 GO:0016787 hydrolase activity
2.90 2.17e-02 GO:0004386 helicase activity
1.75 2.51e-02 GO:0043565 sequence-specific DNA binding
2.42 3.83e-02 GO:0043566 structure-specific DNA binding
1.42 4.41e-02 GO:0016740 transferase activity
4.19 4.93e-02 GO:0003697 single-stranded DNA binding