Motif ID: CRX.p2

Z-value: 1.455


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
Crx 12951 cone-rod homeobox containing gene

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Crxchr7_-_164577330.129.7e-02Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_89991575 20.798 NM_201642
Ugt1a7c
UDP glucuronosyltransferase 1 family, polypeptide A7C
chr5_-_101001209 20.611 NM_139198
Plac8
placenta-specific 8
chr3_-_8964045 19.442 NM_001025261
NM_001025262
Tpd52

tumor protein D52

chrX_-_9046362 18.140 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr1_+_89951985 15.908 NM_201641
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr2_-_58012447 15.438 NM_139200
Cytip
cytohesin 1 interacting protein
chr3_+_127494295 15.409 Tifa
TRAF-interacting protein with forkhead-associated domain
chr1_-_173537404 15.320 NM_008534
Ly9
lymphocyte antigen 9
chr19_-_11679293 15.177 NM_026835
Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr19_-_11679242 14.987 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr5_-_101001191 14.537 Plac8
placenta-specific 8
chr15_+_31154178 13.819 Dap
death-associated protein
chr10_+_87321789 13.623 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chr2_+_145686377 12.832 Rin2
Ras and Rab interactor 2
chr5_+_115347750 12.086 Oasl2
2'-5' oligoadenylate synthetase-like 2
chr8_-_124948837 11.967


chr10_-_61960613 11.858 Srgn
serglycin
chr2_-_51828671 11.708 NM_001141948
NM_001141949
NM_019401
Nmi


N-myc (and STAT) interactor


chr1_+_90062550 11.627 NM_201643
Ugt1a5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr9_+_89949315 11.337 Ctsh
cathepsin H
chr8_-_112103065 10.915 NM_017370
Hp
haptoglobin
chr6_+_67846144 10.878


chr2_-_51828440 10.688 Nmi
N-myc (and STAT) interactor
chr10_-_60561786 10.515


chr1_+_89967340 10.204 NM_201644
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr10_-_60561763 10.015


chr5_+_104868321 9.829 Spp1
secreted phosphoprotein 1
chr7_+_4225744 9.739 NM_011093
NM_008848
Pira6

paired-Ig-like receptor A6

chr19_-_41289262 9.657 Tm9sf3
transmembrane 9 superfamily member 3
chr4_-_19849637 9.595 Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
chr4_-_19849712 9.538 NM_175406
Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
chr6_-_39050297 9.394 Parp12
poly (ADP-ribose) polymerase family, member 12
chr11_-_83388330 9.209 Ccl9
chemokine (C-C motif) ligand 9
chr17_+_87762817 9.159 Ttc7
tetratricopeptide repeat domain 7
chr2_+_145685882 9.083 Rin2
Ras and Rab interactor 2
chr14_-_122314994 9.041 NM_182806
Gpr18
G protein-coupled receptor 18
chr1_+_90062617 8.779 Ugt1a5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr2_-_103104559 8.665 Ehf
ets homologous factor
chr7_-_91763744 8.643 Zfand6
zinc finger, AN1-type domain 6
chr3_+_116564564 8.445 NM_009146
Frrs1
ferric-chelate reductase 1
chr6_+_123212210 8.234 Clec4d
C-type lectin domain family 4, member d
chr5_-_104406333 8.154 Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr19_+_47938880 8.128 Gsto1
glutathione S-transferase omega 1
chr14_+_75576599 8.034 Lcp1
lymphocyte cytosolic protein 1
chr19_-_40345985 8.025 Pdlim1
PDZ and LIM domain 1 (elfin)
chr10_-_87937335 7.986 Chpt1
choline phosphotransferase 1
chr11_+_95703981 7.945 NM_001038664
Gngt2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr9_-_76893529 7.860 NM_012033
Tinag
tubulointerstitial nephritis antigen
chr8_+_120022149 7.734 NM_172285
Plcg2
phospholipase C, gamma 2
chr12_+_36719492 7.715 NM_011783
Agr2
anterior gradient 2 (Xenopus laevis)
chr10_-_53638995 7.641 Man1a
mannosidase 1, alpha
chr7_-_125629996 7.413 Itpripl2
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr4_+_19207954 7.304 NM_013927
Cngb3
cyclic nucleotide gated channel beta 3
chr2_+_24201033 7.297 Il1rn
interleukin 1 receptor antagonist
chr7_-_109005707 7.247 NM_008035
Folr2
folate receptor 2 (fetal)
chr11_-_87639611 7.234 NM_080420
Lpo
lactoperoxidase
chr5_+_20878459 7.233 NM_008013
Fgl2
fibrinogen-like protein 2
chr9_+_89949104 7.199 NM_007801
Ctsh
cathepsin H
chr8_-_95753432 6.972 Ces1e
carboxylesterase 1E
chr6_+_115310883 6.954 Pparg
peroxisome proliferator activated receptor gamma
chr17_+_24035687 6.928 NM_001039238
Dcpp2
demilune cell and parotid protein 2
chr19_+_3935169 6.905 NM_001161428
NM_019449
Unc93b1

unc-93 homolog B1 (C. elegans)

chr16_-_97985323 6.869 NM_023663
Ripk4
receptor-interacting serine-threonine kinase 4
chr16_+_44765848 6.820 NM_021325
Cd200r1
CD200 receptor 1
chr17_-_35325354 6.772 NM_010734
Lst1
leukocyte specific transcript 1
chr11_+_100720664 6.731 NM_011488
Stat5a
signal transducer and activator of transcription 5A
chr2_-_163575826 6.667 NM_007398
Ada
adenosine deaminase
chr3_+_97432726 6.609 NM_001161763
NM_001161765
NM_010232
Fmo5


flavin containing monooxygenase 5


chr19_+_12535268 6.588 NM_010821
Mpeg1
macrophage expressed gene 1
chr11_-_99354417 6.549 NM_033373
Krt23
keratin 23
chr19_+_4097894 6.502 Cdk2ap2
CDK2-associated protein 2
chr6_-_69765093 6.467


chr3_+_95330700 6.367 NM_021281
Ctss
cathepsin S
chr7_+_35905996 6.340 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr7_+_25247448 6.314 NM_011113
Plaur
plasminogen activator, urokinase receptor
chr2_-_25052245 6.261 NM_146115
A830007P12Rik
RIKEN cDNA A830007P12 gene
chr2_+_163332550 6.231 Hnf4a
hepatic nuclear factor 4, alpha
chr1_+_58859345 6.197 NM_001080126
Casp8
caspase 8
chr7_-_20262106 6.176 Apoc2
apolipoprotein C-II
chr11_+_20125239 6.174 Rab1
RAB1, member RAS oncogene family
chr11_+_101309725 6.150 NM_027320
Ifi35
interferon-induced protein 35
chr7_+_51368048 6.149 NM_010114
Klk1b22
kallikrein 1-related peptidase b22
chr7_+_135052004 6.112


chr3_-_113126814 6.076 NM_001160150
NM_001160151
NM_001160152
NM_001042711
Amy2a4
Amy2a3
Amy2a2
Amy2a5
amylase 2a4
amylase 2a3
amylase 2a2
amylase 2a5
chr6_+_115311078 6.029 NM_001127330
Pparg
peroxisome proliferator activated receptor gamma
chr6_+_41304103 6.021 NM_001038996
Try10
trypsin 10
chr18_-_84851298 6.006 Cndp2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr19_-_41289045 6.001 Tm9sf3
transmembrane 9 superfamily member 3
chr11_-_120421805 5.984 P4hb
prolyl 4-hydroxylase, beta polypeptide
chr6_-_115542515 5.962 NM_001101431
2510049J12Rik
RIKEN cDNA 2510049J12 gene
chr8_-_95753501 5.939 NM_133660
Ces1e
carboxylesterase 1E
chr19_+_12535536 5.912 Mpeg1
macrophage expressed gene 1
chr4_+_135750500 5.899 E2f2
E2F transcription factor 2
chr12_-_71332398 5.872 Pygl
liver glycogen phosphorylase
chr15_-_66644127 5.844 NM_009192
Sla
src-like adaptor
chr19_+_4231881 5.821 NM_027196
Pold4
polymerase (DNA-directed), delta 4
chr9_-_114299732 5.774 NM_019922
Crtap
cartilage associated protein
chr14_-_52393218 5.762 NM_177544
Ang4
angiogenin, ribonuclease A family, member 4
chr11_+_97660946 5.757 NM_010688
Lasp1
LIM and SH3 protein 1
chr4_+_62626582 5.677 NM_028326
Zfp618
zinc fingerprotein 618
chr11_-_3817574 5.616 Tcn2
transcobalamin 2
chr10_-_82800561 5.599 NM_177388
Slc41a2
solute carrier family 41, member 2
chr7_-_52317021 5.580 NM_022999
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr10_+_126602182 5.576 NM_008080
B4galnt1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr19_+_4231936 5.504 Pold4
polymerase (DNA-directed), delta 4
chr1_-_87500465 5.493 NM_175397
Sp110
Sp110 nuclear body protein
chr7_-_52409783 5.410 NM_145954
Aldh16a1
aldehyde dehydrogenase 16 family, member A1
chr16_+_57353389 5.394 NM_001040397
Filip1l
filamin A interacting protein 1-like
chr13_+_74777303 5.358 NM_030711
Erap1
endoplasmic reticulum aminopeptidase 1
chr11_+_106612525 5.346 NM_001033435
Gm885
predicted gene 885
chr15_-_76447278 5.334 NM_028064
Slc39a4
solute carrier family 39 (zinc transporter), member 4
chr1_-_89291303 5.264 NM_001110227
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr11_-_70273453 5.249 NM_023158
Cxcl16
chemokine (C-X-C motif) ligand 16
chr3_+_137949734 5.228 Adh1
alcohol dehydrogenase 1 (class I)
chr17_-_57387033 5.201 NM_030084
Gpr108
G protein-coupled receptor 108
chr6_-_69367406 5.194 Igkv4-68
immunoglobulin kappa variable 4-68
chr12_+_99506844 5.162 NM_008152
Gpr65
G-protein coupled receptor 65
chr6_-_3349415 5.116 Samd9l
sterile alpha motif domain containing 9-like
chr5_+_145888588 5.089 Arpc1b
actin related protein 2/3 complex, subunit 1B
chr2_-_84490666 5.055 NM_001085453
Ctnnd1
catenin (cadherin associated protein), delta 1
chr6_-_55124983 5.016 NM_009349
Inmt
indolethylamine N-methyltransferase
chr6_+_70648433 4.979 Igkv3-2
immunoglobulin kappa variable 3-2
chr6_+_68375560 4.943 Igkv16-104
immunoglobulin kappa variable 16-104
chr3_-_96097855 4.897 NM_010186
Fcgr1
Fc receptor, IgG, high affinity I
chr7_-_135073600 4.855 Prss8
protease, serine, 8 (prostasin)
chrX_+_136343083 4.838 Cldn2
claudin 2
chr7_-_135073577 4.809 Prss8
protease, serine, 8 (prostasin)
chr11_+_78734288 4.737 NM_010927
Nos2
nitric oxide synthase 2, inducible
chr6_+_115372083 4.705 NM_011146
Pparg
peroxisome proliferator activated receptor gamma
chr11_+_82878590 4.677 NM_011408
Slfn2
schlafen 2
chr6_+_17699145 4.657 NM_001083315
NM_022332
St7

suppression of tumorigenicity 7

chr11_-_3427914 4.631 Smtn
smoothelin
chr18_-_84849981 4.628 Cndp2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr2_-_163470841 4.608 Serinc3
serine incorporator 3
chr5_-_17394564 4.579 Cd36
CD36 antigen
chr7_+_74792295 4.545 NM_001168475
NM_001168476
NM_001168477
NM_025905
Ttc23



tetratricopeptide repeat domain 23



chr2_-_103105045 4.488 Ehf
ets homologous factor
chr2_+_24831667 4.437 Pnpla7
patatin-like phospholipase domain containing 7
chr5_+_34868420 4.392 NM_011893
Sh3bp2
SH3-domain binding protein 2
chr2_+_24200890 4.389 NM_001039701
Il1rn
interleukin 1 receptor antagonist
chr4_+_130469048 4.386 Laptm5
lysosomal-associated protein transmembrane 5
chr10_+_87322774 4.364 Igf1
insulin-like growth factor 1
chr10_+_88348725 4.338 NM_145423
Slc5a8
solute carrier family 5 (iodide transporter), member 8
chr13_+_54802823 4.326 NM_001033364
Cdhr2
cadherin-related family member 2
chr5_+_64203602 4.289 NM_029554
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr1_+_87546558 4.249 NM_013673
Sp100
nuclear antigen Sp100
chr2_-_25052129 4.248 A830007P12Rik
RIKEN cDNA A830007P12 gene
chr18_-_35900005 4.184 NM_028261
Tmem173
transmembrane protein 173
chr7_+_26449356 4.181 Exosc5
exosome component 5
chr1_-_140071818 4.173 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr15_-_78685925 4.140 NM_025622
Lgals2
lectin, galactose-binding, soluble 2
chr19_+_29326204 4.140 NM_001048177
NM_008413
Jak2

Janus kinase 2

chr1_+_166726827 4.139 NM_019759
Dpt
dermatopontin
chr2_-_84490827 4.130 NM_001085448
NM_001085449
NM_001085450
NM_007615
Ctnnd1



catenin (cadherin associated protein), delta 1



chr10_+_7445867 4.125 Katna1
katanin p60 (ATPase-containing) subunit A1
chr11_-_99489523 4.119 NM_001048196
Krtap4-1
keratin associated protein 4-1
chr1_-_175805812 4.089 Mndal
myeloid nuclear differentiation antigen like
chr11_-_106128935 4.063 NM_031878
Smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr13_-_101086551 4.016 NM_010871
Naip6
NLR family, apoptosis inhibitory protein 6
chr4_-_136965705 4.005 NM_001126318
Gm13011
predicted gene 13011
chr9_-_45012097 3.991 NM_145403
Tmprss4
transmembrane protease, serine 4
chr16_+_32430986 3.986 NM_009981
NM_001163159
Pcyt1a

phosphate cytidylyltransferase 1, choline, alpha isoform

chr2_-_169968174 3.967 NM_001159683
Zfp217
zinc finger protein 217
chr11_-_99354449 3.919 Krt23
keratin 23
chr15_-_103181862 3.881 Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr7_+_117365214 3.863 NM_009302
Swap70
SWA-70 protein
chr2_+_155576943 3.859 NM_011171
Procr
protein C receptor, endothelial
chr9_-_21722533 3.855 NM_031874
Rab3d
RAB3D, member RAS oncogene family
chr9_-_70269326 3.828 NM_007630
Ccnb2
cyclin B2
chr5_-_17355533 3.824 NM_001159556
NM_001159557
Cd36

CD36 antigen

chr19_+_5878465 3.818 NM_134154
Slc25a45
solute carrier family 25, member 45
chr6_+_137359231 3.815 NM_001164402
NM_001164403
Ptpro

protein tyrosine phosphatase, receptor type, O

chr19_-_41288465 3.807 Tm9sf3
transmembrane 9 superfamily member 3
chr16_+_48816968 3.757 NM_023881
Retnlb
resistin like beta
chr6_+_34304098 3.753 NM_008012
Akr1b8
aldo-keto reductase family 1, member B8
chr7_-_3849680 3.751 NM_001166672
NM_011088
NM_011091
NM_011094
Gm14548
Pira11
Pira4
Pira5
Pira7
Lilrb3
predicted gene 14548
paired-Ig-like receptor A11
paired-Ig-like receptor A4
paired-Ig-like receptor A5
paired-Ig-like receptor A7
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr13_-_64468380 3.719 Ctsl
cathepsin L
chr8_+_34681015 3.717 NM_031374
Tex15
testis expressed gene 15
chr4_-_104548965 3.698 NM_146148
C8a
complement component 8, alpha polypeptide
chr16_+_35938555 3.686 NM_030253
Parp9
poly (ADP-ribose) polymerase family, member 9
chr5_-_104406406 3.686 NM_001163486
NM_198030
Hsd17b13

hydroxysteroid (17-beta) dehydrogenase 13

chr7_-_135073508 3.645 Prss8
protease, serine, 8 (prostasin)
chr7_-_3671918 3.622 NM_011095
Lilrb3
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chrX_+_106392094 3.619 NM_001037917
Gm6377
predicted gene 6377
chr7_-_91827857 3.616 NM_022985
Zfand6
zinc finger, AN1-type domain 6
chr7_+_112789644 3.615


chr2_+_122090555 3.613 Sord
sorbitol dehydrogenase
chrX_+_9829439 3.585 NM_008769
Otc
ornithine transcarbamylase
chr4_-_49694854 3.572 NM_001004025
Ppp3r2
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)
chr11_+_87569075 3.566 A430104N18Rik
RIKEN cDNA A430104N18 gene
chr7_-_3820753 3.532 Gm10693
predicted pseudogene 10693
chr6_-_3349470 3.528 NM_010156
Samd9l
sterile alpha motif domain containing 9-like
chr17_+_34729159 3.510 Pbx2
pre B-cell leukemia transcription factor 2
chr17_+_25015708 3.507 NM_008340
Igfals
insulin-like growth factor binding protein, acid labile subunit
chr10_+_51210768 3.464 NM_013532
Lilrb4
leukocyte immunoglobulin-like receptor, subfamily B, member 4
chr6_+_18120686 3.436 NM_021050
Cftr
cystic fibrosis transmembrane conductance regulator homolog
chr14_+_27813547 3.432 NM_010420
Hesx1
homeobox gene expressed in ES cells
chr6_+_48794000 3.430 Tmem176a
transmembrane protein 176A
chr19_-_34736879 3.410 Gm14446
predicted gene 14446
chr14_-_17082321 3.408 NM_027695
Oxsm
3-oxoacyl-ACP synthase, mitochondrial

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.69 5.02e-04 GO:0002376 immune system process
2.11 6.43e-04 GO:0006955 immune response
1.17 4.11e-03 GO:0008152 metabolic process
1.83 1.03e-02 GO:0006952 defense response
2.79 2.50e-02 GO:0007601 visual perception
2.79 2.50e-02 GO:0050953 sensory perception of light stimulus
1.61 3.44e-02 GO:0006629 lipid metabolic process
6.35 3.49e-02 GO:0019915 lipid storage
2.53 3.77e-02 GO:0010876 lipid localization
5.43 4.56e-02 GO:0007602 phototransduction
4.87 4.75e-02 GO:0009583 detection of light stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.80 4.52e-05 GO:0005615 extracellular space
1.63 2.41e-04 GO:0044421 extracellular region part
1.41 1.46e-03 GO:0005576 extracellular region
1.92 2.10e-02 GO:0005792 microsome
1.88 3.67e-02 GO:0042598 vesicular fraction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.19 3.45e-03 GO:0048037 cofactor binding
10.78 1.44e-02 GO:0031419 cobalamin binding
2.60 2.96e-02 GO:0046906 tetrapyrrole binding
1.18 4.45e-02 GO:0003824 catalytic activity
1.72 4.58e-02 GO:0042803 protein homodimerization activity
1.58 4.70e-02 GO:0016491 oxidoreductase activity