Motif ID: CUX2.p2

Z-value: 0.775


Transcription factors associated with CUX2.p2:

Gene SymbolEntrez IDGene Name
Cux2 13048 cut-like homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux2chr5_-_1224978330.397.6e-08Click!


Activity profile for motif CUX2.p2.

activity profile for motif CUX2.p2


Sorted Z-values histogram for motif CUX2.p2

Sorted Z-values for motif CUX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CUX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_54032914 26.101 Fhl1
four and a half LIM domains 1
chr15_-_8660442 25.163 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8660462 23.411 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_68376319 20.966 Schip1
schwannomin interacting protein 1
chr15_-_8660479 20.834 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8660729 19.415 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_68376289 19.181 NM_013928
Schip1
schwannomin interacting protein 1
chr15_-_90764873 18.284 Kif21a
kinesin family member 21A
chrX_+_54032858 17.006 NM_001077362
Fhl1
four and a half LIM domains 1
chr1_-_164796609 13.796 Fmo1
flavin containing monooxygenase 1
chr8_-_70342105 13.003 NM_027626
Psd3
pleckstrin and Sec7 domain containing 3
chr15_-_8660393 8.130 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_19869841 7.738 Cp
ceruloplasmin
chr14_+_14286471 7.112 NM_001163032
Synpr
synaptoporin
chr18_+_57628139 6.815 NM_001134697
Ctxn3
cortexin 3
chr1_+_45368443 6.734 Col3a1
collagen, type III, alpha 1
chrX_-_40627962 5.379 NM_011855
Odz1
odd Oz/ten-m homolog 1 (Drosophila)
chr17_+_86577946 4.661


chr8_+_56040553 4.342 Gpm6a
glycoprotein m6a
chr3_+_19857053 3.532 NM_001042611
NM_007752
Cp

ceruloplasmin

chr15_-_58614642 3.442 Tmem65
transmembrane protein 65
chr10_+_98453513 3.279 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr6_-_136824277 3.272 Mgp
matrix Gla protein
chr10_-_62666659 3.221 NM_182992
Mypn
myopalladin
chr2_-_84615535 3.220 NM_009776
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_+_68996455 3.056 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chr6_-_127075853 2.433 Ccnd2
cyclin D2
chr1_+_11254043 2.430 NM_001033636
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr4_+_94405963 2.279 NM_013690
Tek
endothelial-specific receptor tyrosine kinase
chr7_-_67285104 2.177 NM_001082962
Snrpn
small nuclear ribonucleoprotein N
chr8_+_131028275 2.099 Nrp1
neuropilin 1
chrX_-_72823345 1.845 NM_175122
Rab39b
RAB39B, member RAS oncogene family
chr10_-_63552994 1.755 NM_178678
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_-_113094211 1.623 NM_001160150
NM_001160151
NM_001160152
NM_001042711
Amy2a4
Amy2a3
Amy2a2
Amy2a5
amylase 2a4
amylase 2a3
amylase 2a2
amylase 2a5
chr9_-_102256962 1.594 NM_001168296
NM_173447
Ephb1

Eph receptor B1

chr1_-_141982814 1.569 Cfh
complement component factor h
chrM_+_13543 1.541


chr4_-_136891931 1.509 Cdc42
cell division cycle 42 homolog (S. cerevisiae)
chr4_-_36665923 1.477 NM_001166000
Lingo2
leucine rich repeat and Ig domain containing 2
chr6_+_41252267 1.431 NM_011646
Try4
trypsin 4
chr3_-_113126814 1.376 NM_001160150
NM_001160151
NM_001160152
NM_001042711
Amy2a4
Amy2a3
Amy2a2
Amy2a5
amylase 2a4
amylase 2a3
amylase 2a2
amylase 2a5
chr2_-_30214724 1.330 NM_139302
Sh3glb2
SH3-domain GRB2-like endophilin B2
chr3_+_5218545 1.010 NM_030708
Zfhx4
zinc finger homeodomain 4
chr4_-_96220294 0.969 NM_010008
Cyp2j6
cytochrome P450, family 2, subfamily j, polypeptide 6
chr1_-_172145380 0.962 Uhmk1
U2AF homology motif (UHM) kinase 1
chr9_-_105372402 0.849 Atp2c1
ATPase, Ca++-sequestering
chr4_-_129301106 0.766 NM_025455
Ccdc28b
coiled coil domain containing 28B
chr14_-_52948344 0.743 NM_015772
Sall2
sal-like 2 (Drosophila)
chr17_+_3482314 0.696 Tiam2
T-cell lymphoma invasion and metastasis 2
chr1_+_173144116 0.648 Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr1_+_173144098 0.579 NM_009803
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr11_+_117623703 0.538 Tnrc6c
trinucleotide repeat containing 6C
chr4_-_104548965 0.481 NM_146148
C8a
complement component 8, alpha polypeptide
chr1_+_173144142 0.480 Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr3_-_15426426 0.462 NM_001002898
Sirpb1a
signal-regulatory protein beta 1A
chr9_+_85739048 0.460 Tpbg
trophoblast glycoprotein
chr6_+_41304103 0.422 NM_001038996
Try10
trypsin 10
chr17_+_8428907 0.412 NM_001190333
Ccr6
chemokine (C-C motif) receptor 6
chr3_+_106904470 0.344 NM_008417
Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr3_+_51299153 0.313


chr3_-_103545641 0.264 Hipk1
homeodomain interacting protein kinase 1
chr18_+_53405363 0.252 Snx24
sorting nexing 24
chr12_+_75398460 0.157 NM_198866
Dbpht2
DNA binding protein with his-thr domain
chr3_-_15748418 0.076 NM_001173459
LOC100038947
Sirpb1a
signal-regulatory protein beta 1-like
signal-regulatory protein beta 1A
chr2_-_91516101 0.073 Atg13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr3_+_19857375 0.059 Cp
ceruloplasmin
chr14_-_31756446 0.047 NM_008406
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr11_+_106650565 0.032 NM_001166685
NM_177088
Ccdc45

coiled-coil domain containing 45

chr3_+_51299646 0.029


chr11_-_120486280 0.008 NM_153056
Sirt7
sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)
chr1_-_64167574 0.001 Klf7
Kruppel-like factor 7 (ubiquitous)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
41.24 1.76e-02 GO:0021545 cranial nerve development
37.11 2.43e-02 GO:0006956 complement activation
30.10 4.59e-02 GO:0072376 protein activation cascade

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
101.19 2.59e-04 GO:0001848 complement binding