Motif ID: EVI1.p2

Z-value: 1.425


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
Mecom 14013 MDS1 and EVI1 complex locus

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecomchr3_-_304084080.191.1e-02Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_134439804 44.396 NM_008400
Itgal
integrin alpha L
chr10_-_111434231 18.413 Glipr1
GLI pathogenesis-related 1 (glioma)
chr2_-_58012447 18.139 NM_139200
Cytip
cytohesin 1 interacting protein
chr10_-_111434265 17.862 NM_028608
Glipr1
GLI pathogenesis-related 1 (glioma)
chr6_+_48626133 16.196 NM_174960
Gimap9
GTPase, IMAP family member 9
chr4_-_60675161 14.638 NM_001164526
NM_001134644
NM_001045550
NM_008647
Mup10
Mup11
LOC100048885
Mup19
Mup1
Mup2

major urinary protein 10
major urinary protein 11
major urinary protein LOC100048885
major urinary protein 19
major urinary protein 1
major urinary protein 2

chr1_-_175465858 14.478 BC094916
cDNA sequence BC094916
chr11_-_82834223 14.047 NM_001167743
NM_181545
Slfn8

schlafen 8

chr5_-_88956788 13.477 NM_152839
Igj
immunoglobulin joining chain
chr4_-_60083171 13.401 Mup7
Mup1
major urinary protein 7
major urinary protein 1
chr4_-_61179982 13.392 Mup1
major urinary protein 1
chr4_-_60594469 13.249 Mup1
major urinary protein 1
chr4_-_60594496 13.015 Mup1
major urinary protein 1
chr5_-_138299171 12.636 NM_133209
Pilrb1
paired immunoglobin-like type 2 receptor beta 1
chr17_-_32557916 12.503 NM_021319
Pglyrp2
peptidoglycan recognition protein 2
chr4_-_61335031 11.994 Mup10
LOC100048884
Mup19
Mup1
Mup2
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 19
major urinary protein 1
major urinary protein 2
chr2_+_103809709 11.655 NM_001142336
Lmo2
LIM domain only 2
chr4_-_60434715 11.553 NM_001126319
Mup9
Mup10
LOC100048884
Mup19
Mup1
Mup2
major urinary protein 9
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 19
major urinary protein 1
major urinary protein 2
chr17_-_32557807 11.403 Pglyrp2
peptidoglycan recognition protein 2
chr5_+_34868420 11.180 NM_011893
Sh3bp2
SH3-domain binding protein 2
chr5_-_138312923 11.079 NM_001024932
Pilrb2
paired immunoglobin-like type 2 receptor beta 2
chr13_+_105077914 10.924 NM_001081020
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr4_-_61100653 10.588 NM_001045550
NM_008647
Mup2

major urinary protein 2

chr11_-_115229039 10.202 C630004H02Rik
RIKEN cDNA C630004H02 gene
chr1_+_175560938 10.097 NM_175026
Pyhin1
pyrin and HIN domain family, member 1
chr5_-_138277478 10.023 NM_153510
Pilra
paired immunoglobin-like type 2 receptor alpha
chr4_-_60736086 9.991 Mup10
Mup1
major urinary protein 10
major urinary protein 1
chr19_+_12873063 9.856 NM_134152
Lpxn
leupaxin
chr19_+_12535268 9.805 NM_010821
Mpeg1
macrophage expressed gene 1
chr6_-_129225348 9.550 NM_001033122
Cd69
CD69 antigen
chr4_-_61748264 9.414 NM_001039544
Mup3
major urinary protein 3
chr7_+_149657739 9.359 NM_019391
Lsp1
lymphocyte specific 1
chr2_-_6466116 9.312 Celf2
CUGBP, Elav-like family member 2
chr5_-_138277390 9.169 Pilra
paired immunoglobin-like type 2 receptor alpha
chr10_-_61970481 8.675 NM_011157
Srgn
serglycin
chr2_+_103810274 8.573 NM_001142335
NM_008505
Lmo2

LIM domain only 2

chr4_+_102262447 8.547 NM_001177981
Pde4b
phosphodiesterase 4B, cAMP specific
chr15_+_78156227 8.538 NM_007780
Csf2rb
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr4_-_61443185 8.503 NM_001135127
Mup10
LOC100048884
Mup19
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 19
major urinary protein 1
chr19_+_40734282 8.430 NM_009848
Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr2_+_122252212 8.280 NM_172980
Slc28a2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chr4_-_60594959 8.146 NM_001122647
Mup10
LOC100048884
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 1
chr6_+_67966702 8.058


chr3_+_87161790 8.027 NM_009690
Cd5l
CD5 antigen-like
chr6_-_34860807 7.575 NM_001013366
Wdr91
WD repeat domain 91
chr19_+_12873115 7.307 Lpxn
leupaxin
chr6_-_122806020 7.239 C3ar1
complement component 3a receptor 1
chr11_-_115228986 7.203 NM_175454
C630004H02Rik
RIKEN cDNA C630004H02 gene
chr15_+_3230053 6.903


chr9_-_44334460 6.703 NM_007551
Cxcr5
chemokine (C-X-C motif) receptor 5
chr1_-_175842977 6.692 NM_001033450
Ifi204
Mnda
interferon activated gene 204
myeloid cell nuclear differentiation antigen
chr3_+_106285556 6.688 Dennd2d
DENN/MADD domain containing 2D
chr7_-_86993011 6.647 Anpep
alanyl (membrane) aminopeptidase
chr4_-_133650937 6.563 NM_013706
Cd52
CD52 antigen
chr11_+_48900507 6.535 NM_008330
Ifi47
Olfr56
interferon gamma inducible protein 47
olfactory receptor 56
chr6_+_129347314 6.440 NM_019985
Clec1b
C-type lectin domain family 1, member b
chr1_+_165992203 6.266 NM_001164059
NM_011346
Sell

selectin, lymphocyte

chr8_-_3154851 6.038 Insr
insulin receptor
chr3_+_142223490 5.992 Gbp3
guanylate binding protein 3
chr7_-_113358823 5.902 NM_001039160
NM_029000
Gvin1

GTPase, very large interferon inducible 1

chr7_-_113102453 5.902 NM_001039160
NM_029000
Gvin1

GTPase, very large interferon inducible 1

chr6_-_3349415 5.837 Samd9l
sterile alpha motif domain containing 9-like
chr16_+_49913305 5.804 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr19_-_11410534 5.698 NM_027836
NM_001025610
Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr2_+_85860710 5.611 NM_146578
Olfr1033
olfactory receptor 1033
chr13_-_94407455 5.486 Bhmt
betaine-homocysteine methyltransferase
chr4_-_136441982 5.425 NM_009777
C1qb
complement component 1, q subcomponent, beta polypeptide
chr14_+_41918624 5.354 NM_133653
Mat1a
methionine adenosyltransferase I, alpha
chr14_+_79601537 5.254


chr11_-_116488332 5.247 NM_172572
Rhbdf2
rhomboid 5 homolog 2 (Drosophila)
chr17_-_56261311 5.193 NM_029796
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr6_-_3349470 5.184 NM_010156
Samd9l
sterile alpha motif domain containing 9-like
chr1_+_173770709 5.150 NM_013489
Cd84
CD84 antigen
chr6_-_99385338 5.089 NM_053202
Foxp1
forkhead box P1
chr2_-_7317824 5.044 NM_001110231
Celf2
CUGBP, Elav-like family member 2
chr8_+_68142423 4.985 NM_175188
March1
membrane-associated ring finger (C3HC4) 1
chr10_-_18731766 4.973 NM_001166402
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr7_+_130337876 4.879 Tnrc6a
trinucleotide repeat containing 6a
chr13_-_94407590 4.833 NM_016668
Bhmt
betaine-homocysteine methyltransferase
chr9_+_74823917 4.781 NM_153584
BC031353
cDNA sequence BC031353
chr11_+_85413817 4.683 7030407E18Rik
RIKEN cDNA 7030407E18 gene
chr17_-_35019039 4.627 NM_013484
C2
complement component 2 (within H-2S)
chr13_-_94407548 4.625 Bhmt
betaine-homocysteine methyltransferase
chr10_-_80164559 4.451 NM_172457
Mobkl2a
MOB1, Mps One Binder kinase activator-like 2A (yeast)
chr17_-_35018943 4.404 C2
complement component 2 (within H-2S)
chr2_-_7317513 4.382 NM_001110232
Celf2
CUGBP, Elav-like family member 2
chr1_+_36818669 4.231 NM_009539
Zap70
zeta-chain (TCR) associated protein kinase
chr3_-_15748418 4.189 NM_001173459
LOC100038947
Sirpb1a
signal-regulatory protein beta 1-like
signal-regulatory protein beta 1A
chr3_+_90472990 4.176 NM_013650
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr6_+_113339088 4.174 NM_001142732
Ttll3
Arpc4
tubulin tyrosine ligase-like family, member 3
actin related protein 2/3 complex, subunit 4
chr11_-_48877704 4.133 NM_001145164
Tgtp2
T-cell specific GTPase 2
chr16_-_48772068 4.115 NM_198297
Trat1
T cell receptor associated transmembrane adaptor 1
chr18_+_21103125 4.104 NM_026301
Rnf125
ring finger protein 125
chr1_-_69732373 4.075 NM_011770
Ikzf2
IKAROS family zinc finger 2
chr17_+_34734773 4.072 NM_007425
Ager
advanced glycosylation end product-specific receptor
chr5_+_91223558 4.051 NM_011339
Cxcl15
chemokine (C-X-C motif) ligand 15
chr11_+_117623703 4.024 Tnrc6c
trinucleotide repeat containing 6C
chr1_-_173579128 4.018 Slamf7
SLAM family member 7
chr1_-_146622545 4.016 NM_022881
Rgs18
regulator of G-protein signaling 18
chr4_-_61496155 4.011 NM_008649
Mup5
major urinary protein 5
chr4_-_108874820 3.989 Osbpl9
oxysterol binding protein-like 9
chr2_-_6805937 3.973 NM_001110228
NM_001160293
NM_010160
Celf2


CUGBP, Elav-like family member 2


chr17_-_33897428 3.967 NM_008997
Rab11b
RAB11B, member RAS oncogene family
chr8_-_122346577 3.955


chr17_+_5343877 3.954 Arid1b
AT rich interactive domain 1B (SWI-like)
chr6_+_122902850 3.948 Clec4a3
C-type lectin domain family 4, member a3
chr19_-_7093919 3.928 NM_153795
Fermt3
fermitin family homolog 3 (Drosophila)
chr14_+_56223001 3.872 Irf9
interferon regulatory factor 9
chr3_+_106285348 3.869 NM_001093754
Dennd2d
DENN/MADD domain containing 2D
chr11_-_48877544 3.827 Tgtp2
Tgtp1
T-cell specific GTPase 2
T-cell specific GTPase 1
chr11_+_58020859 3.818 Igtp
interferon gamma induced GTPase
chr7_-_110962416 3.790 NM_008220
NM_016956
Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr2_-_148269170 3.782 NM_010740
Cd93
CD93 antigen
chr2_-_44965603 3.755 Zeb2
zinc finger E-box binding homeobox 2
chr17_+_74898763 3.743 Yipf4
Yip1 domain family, member 4
chr7_+_138712015 3.730 Bub3
budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)
chr4_-_59973470 3.704 NM_008648
Mup4
major urinary protein 4
chr3_+_89904315 3.700


chr17_+_34282215 3.688 NM_010388
H2-DMb1
H2-DMb2
histocompatibility 2, class II, locus Mb1
histocompatibility 2, class II, locus Mb2
chr12_+_87027595 3.675 NM_016767
Batf
basic leucine zipper transcription factor, ATF-like
chr1_-_172906094 3.661 NM_001077189
NM_010187
Fcgr2b

Fc receptor, IgG, low affinity IIb

chr10_-_86470647 3.602 NM_138673
Stab2
stabilin 2
chr6_-_40981647 3.592 2210010C04Rik
RIKEN cDNA 2210010C04 gene
chr19_-_21467250 3.582 Gda
guanine deaminase
chr11_+_98667577 3.560 Msl1
male-specific lethal 1 homolog (Drosophila)
chr9_+_108239210 3.504 Rhoa
ras homolog gene family, member A
chr1_+_61034757 3.490 NM_017480
Icos
inducible T-cell co-stimulator
chr10_-_58904445 3.426 NM_010959
Oit3
oncoprotein induced transcript 3
chr19_-_3903069 3.421 Tcirg1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
chr17_+_34734816 3.330 Ager
advanced glycosylation end product-specific receptor
chr9_-_121825407 3.291 Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr1_-_174149989 3.282 NM_009813
Casq1
calsequestrin 1
chr9_-_121825422 3.280 NM_010012
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr19_-_39961258 3.261 NM_001104525
Cyp2c69
cytochrome P450, family 2, subfamily c, polypeptide 69
chrX_-_49034524 3.239 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr3_-_58934492 3.227 NM_001008497
NM_133200
P2ry14

purinergic receptor P2Y, G-protein coupled, 14

chr17_-_35312945 3.213 NM_019467
Aif1
allograft inflammatory factor 1
chr12_-_104594210 3.181 NM_023049
Asb2
ankyrin repeat and SOCS box-containing 2
chr3_-_20142068 3.165 NM_007753
Cpa3
carboxypeptidase A3, mast cell
chr11_+_49058980 3.157 Mgat1
mannoside acetylglucosaminyltransferase 1
chr1_-_53813191 3.148


chr6_+_122902755 3.142 Clec4a3
C-type lectin domain family 4, member a3
chr11_+_87895626 3.119 Vezf1
vascular endothelial zinc finger 1
chr16_-_3976544 3.111 NM_001081280
Nlrc3
NLR family, CARD domain containing 3
chr17_+_21520684 3.104 NM_172486
Zfp677
zinc finger protein 677
chr16_-_45408997 3.058 NM_010818
Cd200
2300009N04Rik
CD200 antigen
RIKEN cDNA 2300009N04 gene
chrX_-_100678555 3.037 Xist
inactive X specific transcripts
chr17_+_34229284 3.033 NM_008206
H2-Oa
histocompatibility 2, O region alpha locus
chr3_+_136598485 3.021 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr1_-_30930715 3.017 Phf3
PHD finger protein 3
chr9_+_7558428 3.017 NM_008611
Mmp8
matrix metallopeptidase 8
chr11_-_69499014 2.999 NM_001159505
NM_023517
Tnfsf13

tumor necrosis factor (ligand) superfamily, member 13

chr4_-_143571878 2.973 3930401B19Rik
RIKEN cDNA 3930401B19 gene
chr14_-_60012348 2.966 NM_001164289
Gm6907
predicted gene 6907
chr6_-_122806122 2.964 NM_009779
C3ar1
complement component 3a receptor 1
chr19_-_7093834 2.922 Fermt3
fermitin family homolog 3 (Drosophila)
chr10_-_80962400 2.898 S1pr4
sphingosine-1-phosphate receptor 4
chr9_+_124036265 2.891 NM_009917
Ccr5
chemokine (C-C motif) receptor 5
chr7_-_107663293 2.867 NM_153527
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr11_+_83037951 2.864 AI662270
expressed sequence AI662270
chrX_+_6644644 2.858 NM_009651
Akap4
A kinase (PRKA) anchor protein 4
chrX_-_9046362 2.857 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr19_+_29441927 2.850 NM_021893
Cd274
CD274 antigen
chr11_+_114751585 2.836 Cd300a
CD300A antigen
chr10_+_111497244 2.834 NM_027018
Glipr1l1
GLI pathogenesis-related 1 like 1
chr10_+_66648458 2.827 Jmjd1c
jumonji domain containing 1C
chr4_-_108874844 2.826 NM_133885
Osbpl9
oxysterol binding protein-like 9
chr6_+_122902532 2.811 NM_153197
Clec4a3
C-type lectin domain family 4, member a3
chr9_+_103014279 2.808 Rab6b
RAB6B, member RAS oncogene family
chr9_-_88626434 2.803 Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr6_-_48658182 2.795 Gimap6
GTPase, IMAP family member 6
chr6_-_48720814 2.769 NM_031247
Gimap3
GTPase, IMAP family member 3
chr11_+_83037063 2.764 AI662270
expressed sequence AI662270
chr5_+_97520188 2.743 Bmp2k
BMP2 inducible kinase
chr4_-_63064369 2.722 NM_001045514
Akna
AT-hook transcription factor
chr19_+_11611284 2.715 Ms4a4d
membrane-spanning 4-domains, subfamily A, member 4D
chr15_+_78075220 2.715 NM_008677
Ncf4
neutrophil cytosolic factor 4
chr17_+_36005333 2.703 2310014H01Rik
RIKEN cDNA 2310014H01 gene
chr2_-_126444378 2.685 NM_008230
Hdc
histidine decarboxylase
chr13_-_27656440 2.647 NM_023332
Prl8a9
prolactin family8, subfamily a, member 9
chr1_+_132762353 2.647 NM_026976
Faim3
Fas apoptotic inhibitory molecule 3
chr6_-_122806042 2.635 C3ar1
complement component 3a receptor 1
chrX_+_45694534 2.631 NM_178782
Bcorl1
BCL6 co-repressor-like 1
chr6_-_48658211 2.617 NM_153175
Gimap6
GTPase, IMAP family member 6
chr4_-_61811785 2.588 NM_001009550
Mup21
major urinary protein 21
chr3_-_95622554 2.580 NM_001081293
Rprd2
regulation of nuclear pre-mRNA domain containing 2
chr1_+_132762248 2.575 Faim3
Fas apoptotic inhibitory molecule 3
chr5_-_136450345 2.562 NM_001160366
Srcrb4d
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr3_+_95330700 2.549 NM_021281
Ctss
cathepsin S
chr2_+_154959216 2.539 NM_008395
Itch
itchy, E3 ubiquitin protein ligase
chr13_+_43880475 2.536 NM_009856
Cd83
CD83 antigen
chr17_+_56092075 2.532 Ebi3
Epstein-Barr virus induced gene 3
chr13_-_27605067 2.529 NM_023741
Prl8a8
prolactin family 8, subfamily a, member 81
chr7_+_121184667 2.527 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chrX_-_98929396 2.521 NM_009910
Cxcr3
chemokine (C-X-C motif) receptor 3
chr9_-_108962219 2.512 NM_011637
Trex1
three prime repair exonuclease 1
chr6_+_30400873 2.505


chr1_+_5073161 2.505 NM_133826
Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chr8_-_28266926 2.497 Rab11fip1
RAB11 family interacting protein 1 (class I)
chr11_+_97544965 2.482 Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.81 3.31e-06 GO:0002376 immune system process
7.83 1.01e-03 GO:0035456 response to interferon-beta
7.83 1.01e-03 GO:0035458 cellular response to interferon-beta
3.01 1.42e-03 GO:0050670 regulation of lymphocyte proliferation
2.98 1.66e-03 GO:0032944 regulation of mononuclear cell proliferation
2.93 2.27e-03 GO:0070663 regulation of leukocyte proliferation
2.03 2.64e-03 GO:0006955 immune response
2.22 1.00e-02 GO:0050778 positive regulation of immune response
5.08 1.05e-02 GO:0009410 response to xenobiotic stimulus
1.92 1.72e-02 GO:0002684 positive regulation of immune system process
2.29 2.26e-02 GO:0051249 regulation of lymphocyte activation
5.10 2.78e-02 GO:0006805 xenobiotic metabolic process
5.10 2.78e-02 GO:0071466 cellular response to xenobiotic stimulus
2.17 3.88e-02 GO:0002694 regulation of leukocyte activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.47 5.88e-05 GO:0005576 extracellular region
1.74 2.21e-04 GO:0005615 extracellular space
1.60 6.43e-04 GO:0044421 extracellular region part
9.24 2.30e-02 GO:0042101 T cell receptor complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.64 8.90e-03 GO:0004497 monooxygenase activity
5.14 4.50e-02 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen