Motif ID: EWSR1-FLI1.p2

Z-value: 1.359


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
Ewsr1 14030 Ewing sarcoma breakpoint region 1
Fli1 14247 Friend leukemia integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ewsr1chr11_-_4999069-0.272.6e-04Click!
Fli1chr9_-_323488630.046.2e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_79451245 41.390 NM_027455
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr17_+_79451501 39.996 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr11_+_31900378 32.212 NM_008741
Nsg2
neuron specific gene family member 2
chrX_-_133403050 25.457 NM_176971
Rab9b
RAB9B, member RAS oncogene family
chr4_+_43419445 23.104 NM_199057
Rusc2
RUN and SH3 domain containing 2
chr14_-_55585407 22.639 Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr6_-_77929543 21.910 Ctnna2
catenin (cadherin associated protein), alpha 2
chr14_-_55585412 19.030 NM_001164171
NM_010856
Myh6

myosin, heavy polypeptide 6, cardiac muscle, alpha

chr7_-_147268395 18.261 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr16_-_42340613 15.575 NM_008083
Gap43
growth associated protein 43
chr2_-_122420914 14.841 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr6_-_77929685 14.549 Ctnna2
catenin (cadherin associated protein), alpha 2
chr12_+_89055024 14.258 NM_001177573
Gm4027
BB287469
predicted gene 4027
expressed sequence BB287469
chr6_-_77929575 14.152 Ctnna2
catenin (cadherin associated protein), alpha 2
chr6_-_77929660 11.832 NM_001109764
NM_009819
NM_145732
Ctnna2


catenin (cadherin associated protein), alpha 2


chr16_-_28753276 11.704 NM_010199
Fgf12
fibroblast growth factor 12
chr11_+_56825192 10.571 NM_001113325
NM_008165
Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr2_-_91469372 9.869 F2
coagulation factor II
chr16_-_28753298 9.718 Fgf12
fibroblast growth factor 12
chr5_-_121161653 9.621 Dtx1
deltex 1 homolog (Drosophila)
chr12_+_88959817 9.555 NM_001177564
NM_001177573
Gm4027
BB287469
predicted gene 4027
expressed sequence BB287469
chr7_-_20262106 9.486 Apoc2
apolipoprotein C-II
chr11_+_56825307 9.454 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr7_-_20262178 9.321 NM_009695
Apoc2
apolipoprotein C-II
chr2_+_65683823 8.707 NM_153409
NM_178634
Csrnp3

cysteine-serine-rich nuclear protein 3

chr5_-_121161656 8.144 NM_008052
Dtx1
deltex 1 homolog (Drosophila)
chr19_-_40261753 8.074 NM_145499
Cyp2c70
cytochrome P450, family 2, subfamily c, polypeptide 70
chr11_+_56825258 7.799 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr6_-_120772683 7.546 NM_007510
Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr7_-_27724396 7.419 NM_001101467
Cyp2a22
cytochrome P450, family 2, subfamily a, polypeptide 22
chr15_+_25870456 6.989 NM_025459
Fam134b
family with sequence similarity 134, member B
chr5_-_121161612 6.962 Dtx1
deltex 1 homolog (Drosophila)
chr11_-_6420931 6.908 NM_178440
Myo1g
myosin IG
chr9_-_91260619 6.886 NM_009573
Zic1
zinc finger protein of the cerebellum 1
chr6_-_120772651 6.480 Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr5_+_117583596 6.479 NM_001081308
Taok3
TAO kinase 3
chr9_-_57531452 6.411 NM_009993
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
chr1_+_20880690 6.378 Paqr8
progestin and adipoQ receptor family member VIII
chr1_+_20880692 6.197 NM_028829
Paqr8
progestin and adipoQ receptor family member VIII
chr3_+_156224757 6.145 NM_001039094
NM_177274
Negr1

neuronal growth regulator 1

chrX_-_69901382 6.056 NM_008067
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr4_-_41717062 6.048 NM_011336
Ccl27a
chemokine (C-C motif) ligand 27A
chr7_-_110401018 5.883 NM_001001559
Dub2a
deubiquitinating enzyme 2a
chr1_+_20880688 5.867 Paqr8
progestin and adipoQ receptor family member VIII
chr1_+_20880682 5.829 Paqr8
progestin and adipoQ receptor family member VIII
chr1_+_17135421 5.711 NM_010267
Gdap1
ganglioside-induced differentiation-associated-protein 1
chr2_+_136539202 5.595 Snap25
synaptosomal-associated protein 25
chr6_-_28781687 5.499 NM_138682
Lrrc4
leucine rich repeat containing 4
chr17_+_48485725 5.484 NM_031254
Trem2
triggering receptor expressed on myeloid cells 2
chrX_-_163768423 5.477 NM_133211
Tlr7
toll-like receptor 7
chr11_-_6420904 5.420 Myo1g
myosin IG
chr11_+_114751585 5.264 Cd300a
CD300A antigen
chr17_+_70318387 5.131 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_+_84218792 5.111 NM_001024918
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr5_-_135825744 5.074 NM_033571
Fkbp6
FK506 binding protein 6
chrX_+_136916509 5.045 NM_177750
Frmpd3
FERM and PDZ domain containing 3
chrX_+_63902456 4.864 NM_001161431
Slitrk2
SLIT and NTRK-like family, member 2
chr11_-_118770859 4.762 Rbfox3
RNA binding protein, fox-1 homolog (C. elegans) 3
chr9_+_108197453 4.531


chr19_-_21467250 4.530 Gda
guanine deaminase
chr6_-_124813720 4.419 Gpr162
G protein-coupled receptor 162
chr2_-_127347102 4.376 NM_019789
Kcnip3
Kv channel interacting protein 3, calsenilin
chr7_+_35971403 4.344 NM_017394
Slc7a10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chr4_-_42349738 4.205 NM_001164046
Gm13306
predicted gene 13306
chr1_+_136078939 4.150 NM_007695
Chi3l1
chitinase 3-like 1
chr4_+_126290825 4.119


chr13_-_35011860 4.078 NM_027967
1700026J04Rik
RIKEN cDNA 1700026J04 gene
chr9_+_118387748 4.044 Eomes
eomesodermin homolog (Xenopus laevis)
chr4_+_42028814 3.976 NM_001164046
Gm13306
predicted gene 13306
chrX_-_49033640 3.930 NM_015819
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr9_+_104472090 3.899 NM_028719
Cpne4
copine IV
chr2_-_127346987 3.707 Kcnip3
Kv channel interacting protein 3, calsenilin
chr5_+_139882322 3.695 NM_177000
C130050O18Rik
RIKEN cDNA C130050O18 gene
chr4_+_42668782 3.661 NM_001164046
Gm13306
predicted gene 13306
chr11_-_68740550 3.605 NM_145746
Odf4
outer dense fiber of sperm tails 4
chr5_-_73729789 3.505 NM_026950
Ociad2
OCIA domain containing 2
chr5_+_122659745 3.479 NM_001042489
Hvcn1
hydrogen voltage-gated channel 1
chr2_+_136539143 3.418 NM_011428
Snap25
synaptosomal-associated protein 25
chr11_+_60955985 3.348 Tnfrsf13b
tumor necrosis factor receptor superfamily, member 13b
chr6_-_123239886 3.316 NM_019948
Clec4e
C-type lectin domain family 4, member e
chr1_+_136079079 3.303 Chi3l1
chitinase 3-like 1
chr9_+_111341608 3.278 Dclk3
doublecortin-like kinase 3
chr2_+_164793796 3.258 Slc12a5
solute carrier family 12, member 5
chr10_+_21713735 3.250 Sgk1
serum/glucocorticoid regulated kinase 1
chrX_-_49033575 3.248 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr18_+_33098694 3.244 NM_009793
Camk4
calcium/calmodulin-dependent protein kinase IV
chr16_-_36666078 3.238 NM_019388
Cd86
CD86 antigen
chr4_-_115453621 3.133 NM_029196
4930544O15Rik
RIKEN cDNA 4930544O15 gene
chr7_-_133848235 3.099 NM_009898
Coro1a
coronin, actin binding protein 1A
chr5_+_122660225 3.072 NM_028752
Hvcn1
hydrogen voltage-gated channel 1
chr14_-_55735114 3.046 NM_177049
Jph4
junctophilin 4
chr10_-_93002655 3.007 Amdhd1
amidohydrolase domain containing 1
chr12_+_88019649 2.989 NM_177354
Vash1
vasohibin 1
chr9_-_57531425 2.974 Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
chr6_-_128476708 2.970 NM_007376
Pzp
pregnancy zone protein
chrX_-_141122722 2.948 NM_009428
Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr7_+_135754831 2.915 NM_178641
Inpp5f
inositol polyphosphate-5-phosphatase F
chr10_-_38541584 2.911 NM_001177783
Rfpl4b
ret finger protein-like 4B
chr2_-_44968508 2.851 Zeb2
zinc finger E-box binding homeobox 2
chr4_+_126291095 2.802 5730409E04Rik
RIKEN cDNA 5730409E04Rik gene
chr5_+_120284671 2.791 NM_011537
Tbx5
T-box 5
chr15_-_101947088 2.769


chr6_-_123239765 2.762 Clec4e
C-type lectin domain family 4, member e
chr17_+_34766489 2.759 NM_030890
Prrt1
proline-rich transmembrane protein 1
chr2_-_165060188 2.750 NM_174988
Cdh22
cadherin 22
chr6_+_8899165 2.689 Nxph1
neurexophilin 1
chr13_-_61265507 2.674 NM_020284
Ctsr
cathepsin R
chr2_+_164793487 2.634 NM_020333
Slc12a5
solute carrier family 12, member 5
chr2_-_38142866 2.601 NM_146122
Dennd1a
DENN/MADD domain containing 1A
chr7_+_117916117 2.590 NM_009667
Ampd3
adenosine monophosphate deaminase 3
chr9_-_62659736 2.572 Fem1b
feminization 1 homolog b (C. elegans)
chr4_-_25727109 2.520 NM_010243
Fut9
fucosyltransferase 9
chr9_-_109306800 2.505 NM_001014395
Fbxw22
F-box and WD-40 domain protein 22
chr16_+_37580238 2.498 NM_013547
Hgd
homogentisate 1, 2-dioxygenase
chr9_+_111341538 2.495 NM_172928
Dclk3
doublecortin-like kinase 3
chr9_-_109064517 2.480 NM_177069
Fbxw21
F-box and WD-40 domain protein 21
chr8_+_112465553 2.468 Phlpp2
PH domain and leucine rich repeat protein phosphatase 2
chr1_+_54307526 2.463 NM_030025
Ccdc150
coiled-coil domain containing 150
chr14_-_101599285 2.440 NM_029680
1700110M21Rik
RIKEN cDNA 1700110M21 gene
chr2_+_145728955 2.428 NM_001141965
NM_026425
Naa20

N(alpha)-acetyltransferase 20, NatB catalytic subunit

chr18_+_38115192 2.411 NM_153793
Rell2
RELT-like 2
chr9_+_43915391 2.399 NM_001190319
C1qtnf5
C1q and tumor necrosis factor related protein 5
chr2_+_22477837 2.380 NM_008078
Gad2
glutamic acid decarboxylase 2
chr16_+_17898729 2.376 NM_009436
Tssk2
testis-specific serine kinase 2
chr12_+_3806955 2.374 NM_007872
Dnmt3a
DNA methyltransferase 3A
chr7_+_4642529 2.365 NM_001003920
NM_001168572
Brsk1

BR serine/threonine kinase 1

chr10_+_80600716 2.361 Zbtb7a
zinc finger and BTB domain containing 7a
chr2_+_70400179 2.359 NM_008077
Gad1
glutamic acid decarboxylase 1
chr17_+_57244807 2.344 NM_009404
Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chr7_-_25857275 2.336 NM_008168
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
chr13_+_118391270 2.336 Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
chr12_+_110784600 2.263 Meg3
maternally expressed 3
chr9_-_46043339 2.263 NM_023114
Apoc3
apolipoprotein C-III
chrX_+_4446526 2.234 NM_001099643
Gm3750
predicted gene 3750
chr11_+_29593657 2.223 NM_194051
Rtn4
reticulon 4
chr8_-_126384108 2.202 NM_028536
1700054N08Rik
RIKEN cDNA 1700054N08 gene
chr5_-_92792262 2.192 NM_019494
Cxcl11
chemokine (C-X-C motif) ligand 11
chr9_+_118387306 2.152 NM_001164789
NM_010136
Eomes

eomesodermin homolog (Xenopus laevis)

chr17_+_57244828 2.128 Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chr16_+_11066390 2.121 NM_009223
Snn
stannin
chr14_-_103379725 2.105 Kctd12
potassium channel tetramerisation domain containing 12
chrX_+_3748193 2.098 NM_001099643
Gm3750
predicted gene 3750
chr5_+_34763499 2.059 NM_001030306
Fam193a
family with sequence similarity 193, member A
chr1_+_172207448 2.051 NM_012009
Sh2d1b1
SH2 domain protein 1B1
chr5_+_150076605 2.048 NM_009663
Alox5ap
arachidonate 5-lipoxygenase activating protein
chr2_-_150658534 2.039 Abhd12
abhydrolase domain containing 12
chr4_+_53556496 2.027 Slc44a1
solute carrier family 44, member 1
chr5_+_138187182 2.020 NM_023910
Tsc22d4
TSC22 domain family, member 4
chr11_-_118770873 2.017 NM_001024931
NM_001039167
NM_001039168
Rbfox3


RNA binding protein, fox-1 homolog (C. elegans) 3


chr11_-_5815126 1.986 Gck
glucokinase
chr2_+_181255209 1.975 NM_016775
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chrX_+_104451216 1.972 NM_001177781
NM_001033251
Gpr174

G protein-coupled receptor 174

chr11_-_86900220 1.967 1200011M11Rik
RIKEN cDNA 1200011M11 gene
chr11_-_53448203 1.962 NM_008355
Il13
interleukin 13
chr13_+_42804911 1.940 NM_001005740
Phactr1
phosphatase and actin regulator 1
chr2_-_6642489 1.931 Celf2
CUGBP, Elav-like family member 2
chr19_+_29772410 1.915 NM_029993
Mlana
melan-A
chr8_+_77591429 1.908 Tom1
target of myb1 homolog (chicken)
chr12_-_119539840 1.895 Sp4
trans-acting transcription factor 4
chr9_-_21095328 1.889 NM_009878
Cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr17_+_6106858 1.887 Tulp4
tubby like protein 4
chrX_+_8469478 1.870 NM_175327
B630019K06Rik
RIKEN cDNA B630019K06 gene
chr4_+_40669908 1.854 NM_001164671
NM_001164672
Dnaja1

DnaJ (Hsp40) homolog, subfamily A, member 1

chr17_-_28502087 1.851 NM_021478
Tulp1
tubby like protein 1
chr18_+_52927362 1.817 NM_026408
Sncaip
synuclein, alpha interacting protein (synphilin)
chr13_-_51889012 1.813 NM_013660
Sema4d
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr4_+_147976641 1.799 NM_001003893
NM_010767
Masp2

mannan-binding lectin serine peptidase 2

chr9_-_62659364 1.792 NM_010193
Fem1b
feminization 1 homolog b (C. elegans)
chr4_-_41644071 1.789 NM_001146080
NM_016673
Cntfr

ciliary neurotrophic factor receptor

chr2_+_135883963 1.786 6330527O06Rik
RIKEN cDNA 6330527O06 gene
chr13_-_4522566 1.783 NM_054080
Akr1c20
aldo-keto reductase family 1, member C20
chr2_-_181049204 1.774 NM_009133
Stmn3
stathmin-like 3
chrX_-_30292985 1.771 NM_001085545
NM_001085551
NM_001085552
NM_001085553
Gm2933
Gm14345
Gm14346
Gm14351
Gm10921
Gmcl1l
predicted gene 2933
predicted gene 14345
predicted gene 14346
predicted gene 14351
predicted gene 10921
germ cell-less homolog 1 (Drosophila)-like
chr18_+_74019038 1.754 NM_027741
Mro
maestro
chr11_-_86900256 1.738 NM_024262
1200011M11Rik
RIKEN cDNA 1200011M11 gene
chrX_-_104598651 1.734 NM_008409
Itm2a
integral membrane protein 2A
chr6_+_30459848 1.720 NM_027073
1700025E21Rik
RIKEN cDNA 1700025E21 gene
chr6_-_124813922 1.716 NM_013533
Gpr162
G protein-coupled receptor 162
chr2_-_181048957 1.687 Stmn3
stathmin-like 3
chr19_+_40734282 1.682 NM_009848
Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr7_+_107422781 1.679 Pgm2l1
phosphoglucomutase 2-like 1
chr1_+_172163001 1.658 NM_001033499
Sh2d1b2
SH2 domain protein 1B2
chr8_+_77591417 1.652 Tom1
target of myb1 homolog (chicken)
chr19_+_46206383 1.647 NM_007703
Elovl3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr14_-_52924792 1.636 NM_019721
Mettl3
methyltransferase like 3
chr7_+_112706171 1.630 Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr15_-_98593505 1.628 NM_007478
Arf3
ADP-ribosylation factor 3
chr1_+_43009716 1.623 NM_053107
Gpr45
G protein-coupled receptor 45
chr2_+_164793698 1.621 Slc12a5
solute carrier family 12, member 5
chrX_+_5246184 1.610 NM_001085523
Gm14374
predicted gene 14374
chr9_-_109242147 1.599 NM_001177419
NM_001177420
Fbxw14
Fbxw28

F-box and WD-40 domain protein 14
F-box and WD-40 domain protein 28

chr7_-_85722668 1.598 NM_008746
NM_182809
Ntrk3

neurotrophic tyrosine kinase, receptor, type 3

chr2_+_28048511 1.592 Olfm1
olfactomedin 1
chr12_-_119539909 1.589 NM_001166385
NM_009239
Sp4

trans-acting transcription factor 4

chr4_+_40669478 1.588 NM_008298
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr4_+_108952859 1.581 NM_007943
Eps15
epidermal growth factor receptor pathway substrate 15
chrX_-_104598466 1.570 Itm2a
integral membrane protein 2A
chr14_-_52924739 1.567 Mettl3
methyltransferase like 3
chr8_+_19198703 1.567 NM_019728
Defb4
Defb5
defensin beta 4
defensin beta 5
chr17_-_24336901 1.548 NM_001163852
NM_001163853
Tbc1d24

TBC1 domain family, member 24


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.15 1.08e-04 GO:0007268 synaptic transmission
3.22 6.52e-04 GO:0007267 cell-cell signaling
3.29 4.32e-03 GO:0019226 transmission of nerve impulse
3.29 4.32e-03 GO:0035637 multicellular organismal signaling

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.81 8.08e-04 GO:0045202 synapse
2.32 2.74e-02 GO:0043005 neuron projection
22.95 4.55e-02 GO:0034366 spherical high-density lipoprotein particle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.21 3.65e-03 GO:0019899 enzyme binding
1.33 2.29e-02 GO:0005515 protein binding