Motif ID: FOXA2.p3

Z-value: 2.085


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
Foxa2 15376 forkhead box A2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa2chr2_-_1478716300.539.4e-15Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_113061599 39.206 NM_001042711
Amy2a5
amylase 2a5
chr3_-_113094211 35.120 NM_001160150
NM_001160151
NM_001160152
NM_001042711
Amy2a4
Amy2a3
Amy2a2
Amy2a5
amylase 2a4
amylase 2a3
amylase 2a2
amylase 2a5
chr3_-_113126814 30.738 NM_001160150
NM_001160151
NM_001160152
NM_001042711
Amy2a4
Amy2a3
Amy2a2
Amy2a5
amylase 2a4
amylase 2a3
amylase 2a2
amylase 2a5
chr7_+_138175581 30.059 NM_007769
Dmbt1
deleted in malignant brain tumors 1
chr14_-_118450875 26.965 NM_010024
Dct
dopachrome tautomerase
chr12_-_58646914 22.464 Foxa1
forkhead box A1
chr4_+_104438905 20.993 NM_133882
C8b
complement component 8, beta polypeptide
chr10_-_24647243 20.883 NM_007482
Arg1
arginase, liver
chr3_-_113159420 18.704 NM_001160150
NM_001160151
NM_001160152
NM_001042711
Amy2a4
Amy2a3
Amy2a2
Amy2a5
amylase 2a4
amylase 2a3
amylase 2a2
amylase 2a5
chr15_+_74545268 17.991 NM_028216
Psca
prostate stem cell antigen
chr19_-_9162377 17.527 NM_011681
Scgb1a1
secretoglobin, family 1A, member 1 (uteroglobin)
chr16_-_88563421 17.509 NM_018778
Cldn8
claudin 8
chr14_+_103912557 17.310 NM_022886
Scel
sciellin
chr8_+_120225803 17.205 NM_008290
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr5_-_87335956 17.190 NM_153598
Ugt2b34
UDP glucuronosyltransferase 2 family, polypeptide B34
chr6_+_87323350 16.793 NM_025467
Gkn2
gastrokine 2
chr17_-_31281184 16.416 Tff2
trefoil factor 2 (spasmolytic protein 1)
chr4_-_55545337 16.328 NM_010637
Klf4
Kruppel-like factor 4 (gut)
chr6_+_86578550 16.190 Asprv1
aspartic peptidase, retroviral-like 1
chr11_+_96790581 16.137 NM_146026
Prr15l
proline rich 15-like
chr16_-_88563379 15.990 Cldn8
claudin 8
chr4_-_55545211 15.807 Klf4
Kruppel-like factor 4 (gut)
chr17_-_31281223 15.551 NM_009363
Tff2
trefoil factor 2 (spasmolytic protein 1)
chr11_+_28821585 15.448 Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr5_-_88956788 15.287 NM_152839
Igj
immunoglobulin joining chain
chr4_-_57929087 14.956 NM_178727
D630039A03Rik
RIKEN cDNA D630039A03 gene
chr3_-_112959644 14.623 NM_001190403
NM_001190404
Amy2b

amylase 2b

chr6_+_86578269 14.486 Asprv1
aspartic peptidase, retroviral-like 1
chr15_-_5058532 14.276 NM_001163138
Card6
caspase recruitment domain family, member 6
chr5_-_66472208 14.182 Rbm47
RNA binding motif protein 47
chr18_+_20823908 13.733 Ttr
transthyretin
chr8_-_46380114 13.704 Klkb1
kallikrein B, plasma 1
chr8_-_46380165 13.591 NM_008455
Klkb1
kallikrein B, plasma 1
chr1_+_89999782 13.566 NM_201410
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr6_+_70676428 13.357


chr9_-_99617685 13.335 NM_001194921
NM_001194923
Cldn18

claudin 18

chr8_+_120225866 13.267 Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_+_159456274 13.047 NM_001159986
Sec16b
SEC16 homolog B (S. cerevisiae)
chr9_-_99610427 12.921 Cldn18
claudin 18
chr17_-_12868558 12.858 Slc22a1
solute carrier family 22 (organic cation transporter), member 1
chr18_+_70085202 12.720 NM_201362
Ccdc68
coiled-coil domain containing 68
chrX_-_35772763 12.639


chr12_+_113917038 12.607 NM_001100460
Zbtb42
zinc finger and BTB domain containing 42
chr17_-_12868607 12.508 NM_009202
Slc22a1
solute carrier family 22 (organic cation transporter), member 1
chr9_-_99610481 11.963 NM_001194922
NM_019815
Cldn18

claudin 18

chr10_-_20880559 11.891 NM_001198914
NM_010848
Myb

myeloblastosis oncogene

chr12_-_82068951 11.592 Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr6_+_86578225 11.579 Asprv1
aspartic peptidase, retroviral-like 1
chr4_-_57928618 11.453 D630039A03Rik
RIKEN cDNA D630039A03 gene
chr14_-_49282546 11.348 NM_144841
Otx2
orthodenticle homolog 2 (Drosophila)
chr1_+_133558507 11.327 Ctse
cathepsin E
chr16_+_35002066 11.300 Mylk
myosin, light polypeptide kinase
chr1_+_133558486 11.243 Ctse
cathepsin E
chr5_-_17394564 11.203 Cd36
CD36 antigen
chr8_-_112102946 10.956 Hp
haptoglobin
chr3_+_116564564 10.863 NM_009146
Frrs1
ferric-chelate reductase 1
chr6_+_113408477 10.847 NM_145826
Il17re
interleukin 17 receptor E
chr16_+_48872720 10.818 NM_181596
Retnlg
resistin like gamma
chr8_-_64601861 10.725 NM_001136089
NM_011922
Anxa10

annexin A10

chr3_-_154718282 10.686 NM_177066
Tnni3k
TNNI3 interacting kinase
chr10_+_115254308 10.484 NM_001168679
NM_001168680
NM_146010
Tspan8


tetraspanin 8


chr6_+_70676803 10.473


chr19_+_7131270 10.470 Macrod1
MACRO domain containing 1
chr12_-_82069060 10.325 NM_001177561
NM_011387
Slc10a1

solute carrier family 10 (sodium/bile acid cotransporter family), member 1

chr14_+_73637961 10.305 Lpar6
lysophosphatidic acid receptor 6
chr1_+_133558517 10.288 Ctse
cathepsin E
chr6_+_97941776 10.228 NM_008601
Mitf
microphthalmia-associated transcription factor
chr3_+_105916283 10.225 NM_023186
Chia
chitinase, acidic
chr11_+_117675276 10.056 Syngr2
synaptogyrin 2
chr6_+_86578167 9.995 NM_026414
Asprv1
aspartic peptidase, retroviral-like 1
chr8_-_112102961 9.963 Hp
haptoglobin
chr19_+_7131325 9.953 Macrod1
MACRO domain containing 1
chr6_-_83606025 9.929 Clec4f
C-type lectin domain family 4, member f
chr18_+_20823750 9.872 NM_013697
Ttr
transthyretin
chr14_-_31756446 9.806 NM_008406
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr12_+_7984451 9.793 NM_009693
Apob
apolipoprotein B
chr1_+_90097175 9.733 NM_013701
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
chr7_-_112748585 9.708 Hpx
hemopexin
chr1_+_132628552 9.598 NM_177604
AA986860
expressed sequence AA986860
chr6_-_83606100 9.559 NM_016751
Clec4f
C-type lectin domain family 4, member f
chr7_-_112748624 9.507 NM_017371
Hpx
hemopexin
chr4_-_106979732 9.497 NM_007860
Dio1
deiodinase, iodothyronine, type I
chr14_+_73637697 9.490 NM_175116
Lpar6
lysophosphatidic acid receptor 6
chr16_+_30065419 9.463 NM_008235
Hes1
hairy and enhancer of split 1 (Drosophila)
chr12_+_120681882 9.446 NM_001163136
Macc1
metastasis associated in colon cancer 1
chr3_+_94736993 9.432 NM_009150
Selenbp1
selenium binding protein 1
chr14_-_41998434 9.396 NM_009160
Sftpd
surfactant associated protein D
chr7_+_126904427 9.365 NM_016870
NM_212441
NM_212442
Acsm3


acyl-CoA synthetase medium-chain family member 3


chr6_+_15750966 9.340 Mdfic
MyoD family inhibitor domain containing
chr9_+_46076832 9.290 Apoa5
apolipoprotein A-V
chr6_-_87338847 9.281 NM_026860
Gkn3
gastrokine 3
chr3_+_94736974 9.141 Selenbp1
selenium binding protein 1
chr11_+_58028487 9.132 Irgm2
immunity-related GTPase family M member 2
chr11_+_61022240 9.052 NM_001112725
NM_007436
Aldh3a1

aldehyde dehydrogenase family 3, subfamily A1

chr19_+_58803376 9.027 NM_018874
Pnliprp1
pancreatic lipase related protein 1
chr7_-_29678773 8.960 Actn4
actinin alpha 4
chr3_+_94497485 8.905 NM_019414
Selenbp2
selenium binding protein 2
chr5_+_116005777 8.887 Pxn
paxillin
chr14_+_79601537 8.878


chr15_+_6529846 8.722 NM_011815
Fyb
FYN binding protein
chr12_+_77471506 8.613 Zbtb1
zinc finger and BTB domain containing 1
chr10_+_127705664 8.600 Apof
apolipoprotein F
chr16_+_17331463 8.593 NM_008223
Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr10_+_127335573 8.556 NM_027301
Sdr9c7
4short chain dehydrogenase/reductase family 9C, member 7
chr3_-_95708543 8.460 NM_011797
Car14
carbonic anhydrase 14
chr16_+_17331507 8.375 Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr5_-_17355533 8.352 NM_001159556
NM_001159557
Cd36

CD36 antigen

chr7_+_147949637 8.265 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr19_-_20802015 8.237 NM_011921
Aldh1a7
aldehyde dehydrogenase family 1, subfamily A7
chr13_-_38069696 8.195


chr17_+_34766489 8.194 NM_030890
Prrt1
proline-rich transmembrane protein 1
chr10_-_60915251 8.181 NM_010124
Eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
chr1_-_135972341 8.155


chr3_-_105970438 8.008 NM_009892
Chi3l3
chitinase 3-like 3
chr6_+_124254668 7.906 NM_001170395
NM_053094
Cd163

CD163 antigen

chr6_+_90424727 7.896 Klf15
Kruppel-like factor 15
chr6_-_87793459 7.860 Cnbp
cellular nucleic acid binding protein
chr19_+_55816299 7.834 NM_001142918
NM_001142919
NM_001142920
NM_001142921
NM_001142922
NM_001142923
NM_009333
Tcf7l2






transcription factor 7-like 2, T-cell specific, HMG-box






chr11_+_110260435 7.793 NM_011943
Map2k6
mitogen-activated protein kinase kinase 6
chr3_+_106288967 7.790 NM_028110
Dennd2d
DENN/MADD domain containing 2D
chr6_-_3444484 7.778 NM_178899
Hepacam2
HEPACAM family member 2
chr10_+_23571267 7.773 NM_011979
Vnn3
vanin 3
chr9_+_53109774 7.771 NM_176846
Exph5
exophilin 5
chr6_-_5143755 7.766 NM_011134
Pon1
paraoxonase 1
chr3_-_115710131 7.746 NM_023214
Slc30a7
solute carrier family 30 (zinc transporter), member 7
chr7_-_94641859 7.558 NM_011661
Tyr
tyrosinase
chrX_+_157205944 7.558 NM_011302
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr1_+_45402907 7.531 Col3a1
collagen, type III, alpha 1
chr12_+_77471173 7.528 NM_178744
Zbtb1
zinc finger and BTB domain containing 1
chr6_+_135312948 7.413 NM_010128
Emp1
epithelial membrane protein 1
chr9_+_46076689 7.396 NM_080434
Apoa5
apolipoprotein A-V
chr15_-_102008126 7.388


chr6_+_87040212 7.344 Gfpt1
glutamine fructose-6-phosphate transaminase 1
chr16_+_22892112 7.338 NM_013465
Ahsg
alpha-2-HS-glycoprotein
chr6_-_134741351 7.329 Dusp16
dual specificity phosphatase 16
chr1_+_89951985 7.284 NM_201641
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr11_+_94426358 7.255 NM_007689
Chad
chondroadherin
chr3_-_131047840 7.249 NM_028943
Sgms2
sphingomyelin synthase 2
chr7_+_109378512 7.234 Pgap2
post-GPI attachment to proteins 2
chr17_+_34400152 7.212 NM_207105
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr10_+_127142225 7.161 NM_001081219
Myo1a
myosin IA
chr5_+_65221116 7.160 Klf3
Kruppel-like factor 3 (basic)
chr8_-_112103065 7.091 NM_017370
Hp
haptoglobin
chr6_+_135313010 7.050 Emp1
epithelial membrane protein 1
chr16_+_22892125 6.977 Ahsg
alpha-2-HS-glycoprotein
chr15_+_54242324 6.920 NM_173422
Colec10
collectin sub-family member 10
chr3_-_20174589 6.912 NM_029706
Cpb1
carboxypeptidase B1 (tissue)
chrX_-_93488752 6.859 NM_177789
Vsig4
V-set and immunoglobulin domain containing 4
chr19_-_44103644 6.810 NM_001001446
NM_001167905
Cyp2c44

cytochrome P450, family 2, subfamily c, polypeptide 44

chr1_-_138856866 6.803 NM_030676
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr10_-_127325668 6.800 Rdh7
retinol dehydrogenase 7
chr10_-_88996314 6.779 NM_001163504
Nr1h4
nuclear receptor subfamily 1, group H, member 4
chr11_+_87895626 6.735 Vezf1
vascular endothelial zinc finger 1
chr7_+_52976589 6.726 NM_001033170
Fam83e
family with sequence similarity 83, member E
chr3_-_144695718 6.677 NM_017474
Clca3
chloride channel calcium activated 3
chr19_+_7131234 6.648 NM_134147
Macrod1
MACRO domain containing 1
chr16_+_33518414 6.618 NM_134251
Slc12a8
solute carrier family 12 (potassium/chloride transporters), member 8
chr17_-_7997838 6.598 NM_001081416
Fndc1
fibronectin type III domain containing 1
chr10_+_127691272 6.588 Apon
apolipoprotein N
chr3_+_19857053 6.588 NM_001042611
NM_007752
Cp

ceruloplasmin

chr5_-_91069499 6.570 NM_028478
Rassf6
Ras association (RalGDS/AF-6) domain family member 6
chr16_-_22811458 6.559 NM_009967
Crygs
crystallin, gamma S
chr10_-_24647173 6.553 Arg1
arginase, liver
chrX_+_160578411 6.479 NM_027286
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_+_96636596 6.439 NM_001146001
Pdzk1
PDZ domain containing 1
chr16_+_37580238 6.434 NM_013547
Hgd
homogentisate 1, 2-dioxygenase
chr16_+_33500899 6.418 Zfp148
zinc finger protein 148
chr2_+_153834000 6.416 NM_008953
Psp
parotid secretory protein
chr2_-_27118325 6.413 Vav2
vav 2 oncogene
chrX_-_35793335 6.383 Lamp2
lysosomal-associated membrane protein 2
chr19_-_38117813 6.380 Myof
myoferlin
chr10_-_117252126 6.376


chr2_-_60560659 6.370 NM_001159564
Itgb6
integrin beta 6
chr2_-_62321694 6.331 NM_008100
Gcg
glucagon
chr16_+_22892156 6.314 Ahsg
alpha-2-HS-glycoprotein
chr3_+_135488454 6.307 NM_026228
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr5_-_146691425 6.296 NM_007818
Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
chr7_+_120909680 6.256 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr17_+_12571494 6.235 Plg
plasminogen
chr3_-_8964045 6.232 NM_001025261
NM_001025262
Tpd52

tumor protein D52

chr4_-_49562319 6.227 NM_144903
Aldob
aldolase B, fructose-bisphosphate
chr6_+_34659440 6.225 NM_145575
Cald1
caldesmon 1
chr10_+_42580317 6.191 NM_172938
Scml4
sex comb on midleg-like 4 (Drosophila)
chr7_-_77511242 6.173 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr3_-_81779636 6.170 NM_019911
Tdo2
tryptophan 2,3-dioxygenase
chr11_-_31724523 6.161 D630024D03Rik
RIKEN cDNA D630024D03 gene
chr16_+_34995000 6.151 Mylk
myosin, light polypeptide kinase
chr19_+_20676453 6.104 NM_013467
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr13_+_4190423 6.093 NM_013778
Akr1c13
aldo-keto reductase family 1, member C13
chr10_-_78180902 6.083 NM_009809
Casp14
caspase 14
chr6_+_30491641 6.055 NM_001024698
Cpa2
carboxypeptidase A2, pancreatic
chr1_+_140864297 6.051 NM_181347
Dennd1b
DENN/MADD domain containing 1B
chr1_-_138130840 6.044 NM_028872
5730559C18Rik
RIKEN cDNA 5730559C18 gene
chr9_-_44611055 6.038 Ttc36
tetratricopeptide repeat domain 36
chr3_+_138078450 6.024 NM_011996
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr1_+_45390415 6.022 Col3a1
collagen, type III, alpha 1
chr19_-_34329804 6.009 NM_007392
Acta2
actin, alpha 2, smooth muscle, aorta
chr17_+_12571455 5.929 NM_008877
Plg
plasminogen
chr12_-_104976324 5.925 Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr11_+_3931731 5.798 NM_146013
Sec14l4
SEC14-like 4 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.61 2.81e-06 GO:0042221 response to chemical stimulus
2.36 1.13e-05 GO:0009611 response to wounding
1.77 1.38e-04 GO:0002376 immune system process
2.04 2.59e-04 GO:0006952 defense response
2.62 8.22e-04 GO:0006954 inflammatory response
1.62 3.33e-03 GO:0010033 response to organic substance
3.54 1.02e-02 GO:0007596 blood coagulation
3.54 1.02e-02 GO:0050817 coagulation
2.04 1.05e-02 GO:0006955 immune response
2.85 1.17e-02 GO:0002683 negative regulation of immune system process
1.47 1.18e-02 GO:0048583 regulation of response to stimulus
3.49 1.22e-02 GO:0007599 hemostasis
1.93 1.55e-02 GO:0080134 regulation of response to stress
1.35 1.55e-02 GO:0048522 positive regulation of cellular process
10.11 1.75e-02 GO:0051917 regulation of fibrinolysis
1.33 2.03e-02 GO:0048518 positive regulation of biological process
1.36 2.34e-02 GO:0048519 negative regulation of biological process
5.27 2.40e-02 GO:0030193 regulation of blood coagulation
7.86 2.55e-02 GO:0071346 cellular response to interferon-gamma
4.75 2.61e-02 GO:0050818 regulation of coagulation
16.85 2.94e-02 GO:0051919 positive regulation of fibrinolysis
4.63 3.41e-02 GO:0061041 regulation of wound healing
6.42 3.62e-02 GO:0050819 negative regulation of coagulation
1.58 4.03e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
3.69 4.30e-02 GO:0019748 secondary metabolic process
7.37 4.31e-02 GO:0030195 negative regulation of blood coagulation
1.72 4.70e-02 GO:0070887 cellular response to chemical stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.85 9.54e-15 GO:0005576 extracellular region
1.99 1.03e-09 GO:0044421 extracellular region part
2.03 1.27e-07 GO:0005615 extracellular space
10.11 2.19e-03 GO:0018995 host
10.11 2.19e-03 GO:0033643 host cell part
10.11 2.19e-03 GO:0043245 extraorganismal space
10.11 2.19e-03 GO:0043657 host cell
10.11 2.19e-03 GO:0044215 other organism
10.11 2.19e-03 GO:0044216 other organism cell
10.11 2.19e-03 GO:0044217 other organism part
10.53 1.05e-02 GO:0020003 symbiont-containing vacuole
9.36 2.24e-02 GO:0030430 host cell cytoplasm
9.36 2.24e-02 GO:0033646 host intracellular part
9.36 2.24e-02 GO:0033655 host cell cytoplasm part
9.36 2.24e-02 GO:0043656 intracellular region of host

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.26 3.46e-04 GO:0016564 transcription repressor activity
2.71 1.17e-03 GO:0030414 peptidase inhibitor activity
2.65 4.10e-03 GO:0004866 endopeptidase inhibitor activity
1.98 6.35e-03 GO:0030246 carbohydrate binding
2.55 7.94e-03 GO:0061135 endopeptidase regulator activity
2.28 1.51e-02 GO:0005529 sugar binding
2.32 2.11e-02 GO:0061134 peptidase regulator activity
2.89 2.35e-02 GO:0004867 serine-type endopeptidase inhibitor activity
1.64 2.43e-02 GO:0016491 oxidoreductase activity
6.55 2.51e-02 GO:0008514 organic anion transmembrane transporter activity
7.22 4.75e-02 GO:0015125 bile acid transmembrane transporter activity