Motif ID: FOXD3.p2

Z-value: 2.001


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
Foxd3 15221 forkhead box D3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxd3chr4_+_993229890.009.8e-01Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_110783593 113.367 Meg3
maternally expressed 3
chr5_-_104543106 73.266 NM_010097
Sparcl1
SPARC-like 1
chr12_+_110783786 70.651 Meg3
maternally expressed 3
chr6_-_60779848 67.803 NM_009221
Snca
synuclein, alpha
chr3_-_57105840 64.139 NM_008536
Tm4sf1
transmembrane 4 superfamily member 1
chr9_-_14185950 60.043 Endod1
endonuclease domain containing 1
chr4_-_117881591 53.920 Ptprf
protein tyrosine phosphatase, receptor type, F
chr14_-_71029960 48.413 NM_013514
Epb4.9
erythrocyte protein band 4.9
chr9_-_49311823 46.848 Ncam1
neural cell adhesion molecule 1
chr8_-_74150754 46.207 Unc13a
unc-13 homolog A (C. elegans)
chr19_-_4906607 45.384 NM_001033128
Bbs1
Bardet-Biedl syndrome 1 (human)
chr10_+_79167102 44.318 NM_001077184
NM_009768
Bsg

basigin

chr9_+_78039786 43.841 Gsta4
glutathione S-transferase, alpha 4
chr9_+_45646611 43.434 NM_001145947
NM_011792
Bace1

beta-site APP cleaving enzyme 1

chr19_+_53403902 42.076 NM_010847
Mxi1
Max interacting protein 1
chr4_+_146124224 40.461 NM_001177546
Zfp600
zinc finger protein 600
chr4_+_104829963 38.883 Ppap2b
phosphatidic acid phosphatase type 2B
chr1_-_72905107 38.874 Igfbp5
insulin-like growth factor binding protein 5
chr16_+_7409879 38.754 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr18_-_25637339 38.014 Celf4
CUGBP, Elav-like family member 4
chr1_+_45390415 36.941 Col3a1
collagen, type III, alpha 1
chr10_+_68996455 36.058 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chr17_+_36131397 35.155 A930015D03Rik
RIKEN cDNA A930015D03 gene
chr4_+_104829867 32.215 Ppap2b
phosphatidic acid phosphatase type 2B
chr2_+_103909961 31.850 Cd59b
CD59b antigen
chr6_+_4490515 31.767 Col1a2
collagen, type I, alpha 2
chr18_-_36926866 31.369


chr4_+_104830022 31.275 Ppap2b
phosphatidic acid phosphatase type 2B
chr2_+_145068346 30.811 NM_053195
Slc24a3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr19_+_30020236 30.568 NM_001164724
Il33
interleukin 33
chr15_+_101858606 29.538 NM_010664
Krt18
keratin 18
chr13_+_97837240 28.767 NM_001146045
Fam169a
family with sequence similarity 169, member A
chr10_+_24315247 28.747 NM_010217
Ctgf
connective tissue growth factor
chr9_+_92502076 28.521


chr18_-_25637786 27.576 Celf4
CUGBP, Elav-like family member 4
chr13_+_59234737 26.797 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr9_+_109905895 26.561


chr4_+_104829951 25.592 NM_080555
Ppap2b
phosphatidic acid phosphatase type 2B
chr11_-_102666332 25.504 NM_008122
Gjc1
gap junction protein, gamma 1
chr1_-_170085342 25.172 Pbx1
pre B-cell leukemia transcription factor 1
chr2_+_70400179 25.007 NM_008077
Gad1
glutamic acid decarboxylase 1
chr3_-_152003317 24.562 NM_001162375
NM_174868
Fam73a

family with sequence similarity 73, member A

chr11_-_53083217 24.282 Hspa4
heat shock protein 4
chr11_-_86517662 23.568 Cltc
clathrin, heavy polypeptide (Hc)
chr9_-_14185399 23.534 Endod1
endonuclease domain containing 1
chr5_+_137994744 23.202 NM_031404
Actl6b
actin-like 6B
chr14_-_26722378 23.054 NM_207229
Plac9
placenta specific 9
chr14_-_27001758 22.960 NM_207229
Plac9
placenta specific 9
chr1_+_168184269 22.315 NM_001164528
Ildr2
immunoglobulin-like domain containing receptor 2
chr7_-_31411149 22.186 NM_025628
Cox6b1
cytochrome c oxidase, subunit VIb polypeptide 1
chr7_-_147268395 22.137 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr16_-_28929698 22.114 NM_177718
1600021P15Rik
RIKEN cDNA 1600021P15 gene
chr9_-_14185685 21.905 NM_028013
Endod1
endonuclease domain containing 1
chrX_+_162782484 21.863 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
Gpm6b





glycoprotein m6b





chr7_-_151621960 21.268 Cttn
cortactin
chr16_+_43619057 20.945 Zbtb20
zinc finger and BTB domain containing 20
chr4_+_94406190 20.855 Tek
endothelial-specific receptor tyrosine kinase
chr1_+_45402907 20.832 Col3a1
collagen, type III, alpha 1
chr1_-_45460310 20.788 Col5a2
collagen, type V, alpha 2
chr13_+_42961598 20.617 Phactr1
phosphatase and actin regulator 1
chr2_+_67955769 20.390 NM_020283
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr10_-_127935725 20.235 NM_172259
Myl6b
myosin, light polypeptide 6B
chr11_+_69435553 20.102 NM_026991
Sat2
spermidine/spermine N1-acetyl transferase 2
chr8_-_85982247 19.951 NM_001039137
Scoc
short coiled-coil protein
chr17_+_75784448 19.829 Ltbp1
latent transforming growth factor beta binding protein 1
chr15_+_4325490 19.739 NM_177355
Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr4_-_15076940 19.680 Necab1
N-terminal EF-hand calcium binding protein 1
chr5_-_143665305 19.587 Actb
actin, beta
chr1_-_134638361 19.580 NM_001160317
NM_182716
Nfasc

neurofascin

chr6_+_88775664 19.464 Mgll
monoglyceride lipase
chr4_+_138012860 19.391 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr4_+_149022266 19.265


chr16_+_48310386 19.143 NM_028615
Dppa2
developmental pluripotency associated 2
chr2_+_97307652 18.994 NM_178725
Lrrc4c
leucine rich repeat containing 4C
chr18_-_16966954 18.973 Cdh2
cadherin 2
chr5_-_139606339 18.782 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_-_76240202 18.720 NM_011211
Ptprd
protein tyrosine phosphatase, receptor type, D
chr13_-_36826104 18.431 Nrn1
neuritin 1
chr11_-_41813792 18.366 NM_177408
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr19_+_20676453 18.302 NM_013467
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr11_+_97702591 18.281 B230217C12Rik
RIKEN cDNA B230217C12 gene
chr3_+_94926272 18.108


chr10_-_75931585 17.937 Ybey
ybeY metallopeptidase
chr14_-_26862144 17.881 NM_207229
Plac9
placenta specific 9
chr8_-_87297283 17.674 Nfix
nuclear factor I/X
chr13_+_14705508 17.672 NM_008944
Psma2
proteasome (prosome, macropain) subunit, alpha type 2
chr16_-_44558929 17.584 NM_172506
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr1_-_42749940 17.475 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr9_-_30957394 17.416


chr12_-_73509668 17.410 Rtn1
reticulon 1
chr6_-_92431385 17.177 NM_001134460
Prickle2
prickle homolog 2 (Drosophila)
chr5_-_52957466 17.150 Lgi2
leucine-rich repeat LGI family, member 2
chr7_+_19876447 17.112 NM_001025364
Rtn2
reticulon 2 (Z-band associated protein)
chr2_+_152561983 17.094 NM_010495
Id1
inhibitor of DNA binding 1
chrX_-_147248815 17.078 NM_030700
Maged2
melanoma antigen, family D, 2
chr8_+_46744023 16.999 Sorbs2
sorbin and SH3 domain containing 2
chr11_+_97702093 16.965 NM_001080935
B230217C12Rik
RIKEN cDNA B230217C12 gene
chr16_-_31314534 16.886 NM_007470
Apod
apolipoprotein D
chr8_-_26895633 16.885 NM_026121
Bag4
BCL2-associated athanogene 4
chr1_-_194681914 16.876 NM_198247
Sertad4
SERTA domain containing 4
chr1_-_137064124 16.826 NM_134438
Gpr37l1
G protein-coupled receptor 37-like 1
chr7_-_116651647 16.647 NM_001170912
NM_181853
Trim66

tripartite motif-containing 66

chr10_+_96942124 16.615 NM_001190451
Dcn
decorin
chr7_-_51920870 16.337 NM_028021
Myh14
myosin, heavy polypeptide 14
chr5_-_5265981 16.333 Cdk14
cyclin-dependent kinase 14
chr14_+_76354807 16.203 NM_026214
Kctd4
potassium channel tetramerisation domain containing 4
chr1_-_79436564 16.060 NM_009129
Scg2
secretogranin II
chr2_+_106533281 16.024 Mpped2
metallophosphoesterase domain containing 2
chr5_-_51848420 15.906 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr11_-_41814008 15.903 NM_008073
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr7_-_148615247 15.862 NM_021316
Cend1
cell cycle exit and neuronal differentiation 1
chr6_-_42643001 15.809 NM_029930
Fam115a
family with sequence similarity 115, member A
chr8_-_87298118 15.470 NM_001081981
Nfix
nuclear factor I/X
chr1_+_137904795 15.232 NM_001160145
Tmem9
transmembrane protein 9
chrX_+_133371611 15.231 Plp1
proteolipid protein (myelin) 1
chr18_-_25912171 15.131 Celf4
CUGBP, Elav-like family member 4
chr9_-_21822333 15.098 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr6_+_141472906 14.984 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr18_+_82754829 14.850 Mbp
myelin basic protein
chr6_+_135148004 14.833 NM_028982
8430419L09Rik
RIKEN cDNA 8430419L09 gene
chr9_-_53822931 14.754 Elmod1
ELMO domain containing 1
chr19_-_42160732 14.690 NM_198108
Morn4
MORN repeat containing 4
chr7_-_151627653 14.657 Cttn
cortactin
chr3_+_90346956 14.633 S100a16
S100 calcium binding protein A16
chr9_+_43901941 14.606 Usp2
ubiquitin specific peptidase 2
chr6_+_34659440 14.488 NM_145575
Cald1
caldesmon 1
chr9_-_108363911 14.483 NM_030075
Klhdc8b
kelch domain containing 8B
chr4_-_144311306 14.421 NM_001085536
Gm13178
predicted gene 13178
chr15_+_91991704 14.368 NM_001159647
Cntn1
contactin 1
chr11_-_79317471 14.259 Omg
oligodendrocyte myelin glycoprotein
chr9_+_92502908 14.252 Plod2
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr12_-_73509925 14.248 NM_153457
Rtn1
reticulon 1
chr12_+_118896501 14.205 Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_92100572 14.108 NM_007722
Cxcr7
chemokine (C-X-C motif) receptor 7
chr17_+_75578120 14.098 NM_206958
Ltbp1
latent transforming growth factor beta binding protein 1
chr18_-_23197156 13.837 NM_001161483
Nol4
nucleolar protein 4
chr12_+_110800212 13.754 Meg3
maternally expressed 3
chr15_-_101700048 13.737 NM_001003667
Krt77
keratin 77
chr7_+_25055436 13.716 NM_009567
Zfp93
zinc finger protein 93
chr6_+_54402876 13.669 NM_001167860
NM_001167861
Wipf3

WAS/WASL interacting protein family, member 3

chr2_+_14525932 13.652 NM_023116
Cacnb2
calcium channel, voltage-dependent, beta 2 subunit
chr12_+_39506844 13.492 NM_007960
Etv1
ets variant gene 1
chr10_-_82996799 13.415 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr8_-_67171692 13.414 Cpe
carboxypeptidase E
chr14_+_4126976 13.388 NM_001029930
ENSMUSG00000068790
predicted gene, ENSMUSG00000068790
chr17_-_45724536 13.348 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr7_-_25084361 13.336 Zfp61
zinc finger protein 61
chr7_-_52230091 13.329 Cpt1c
carnitine palmitoyltransferase 1c
chr7_+_53693190 13.111 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr2_+_152512797 12.959 NM_025543
Mcts2
malignant T cell amplified sequence 2
chr16_-_10447440 12.915 NM_001013778
Fam18a
family with sequence similarity 18, member A
chr9_-_91255831 12.896 Zic1
zinc finger protein of the cerebellum 1
chr16_-_38433223 12.811 NM_134102
Pla1a
phospholipase A1 member A
chr17_-_15963372 12.779 NM_178615
Rgmb
RGM domain family, member B
chr10_-_82996846 12.714 NM_153543
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr2_+_59192308 12.634 Pkp4
plakophilin 4
chr8_-_113426341 12.629 NM_172283
NM_181666
Fuk

fucokinase

chr13_-_64468380 12.594 Ctsl
cathepsin L
chr10_+_127759711 12.547 Cnpy2
canopy 2 homolog (zebrafish)
chrX_+_10173557 12.534


chr6_+_90424727 12.465 Klf15
Kruppel-like factor 15
chr9_-_108363229 12.439 Klhdc8b
kelch domain containing 8B
chrX_+_102318792 12.394 Magee1
melanoma antigen, family E, 1
chr7_+_19868009 12.393 NM_013648
Rtn2
reticulon 2 (Z-band associated protein)
chr3_-_148617598 12.379 NM_001081298
Lphn2
latrophilin 2
chr10_+_96942181 12.346 Dcn
decorin
chr2_+_103935948 12.329 NM_001111060
NM_007652
Cd59a

CD59a antigen

chr17_-_33170297 12.305 NM_028543
Zfp763
zinc finger protein 763
chr9_-_53823107 12.248 NM_177769
Elmod1
ELMO domain containing 1
chr11_+_44431601 12.219 NM_007897
Ebf1
early B-cell factor 1
chr11_+_78312621 12.159 NM_011707
Vtn
vitronectin
chr5_+_136108487 12.008 NM_146002
Rhbdd2
rhomboid domain containing 2
chr6_-_137519272 11.979 Eps8
epidermal growth factor receptor pathway substrate 8
chr10_+_127759640 11.911 Cnpy2
canopy 2 homolog (zebrafish)
chr18_+_37849488 11.869 NM_033575
Pcdhgb2
protocadherin gamma subfamily B, 2
chr1_-_99873795 11.819 Pam
peptidylglycine alpha-amidating monooxygenase
chr8_-_108282498 11.817 NM_027469
Gfod2
glucose-fructose oxidoreductase domain containing 2
chr14_+_84843366 11.741 NM_001013753
Pcdh17
protocadherin 17
chr18_+_37854011 11.717 NM_033588
Pcdhga5
protocadherin gamma subfamily A, 5
chr7_-_91520991 11.644 Arnt2
aryl hydrocarbon receptor nuclear translocator 2
chr3_-_117571789 11.622 Snx7
sorting nexin 7
chr11_-_116668593 11.581


chr11_+_28753190 11.559 NM_146015
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr7_+_135047561 11.540 NM_009739
Bckdk
branched chain ketoacid dehydrogenase kinase
chr6_-_142650737 11.495 NM_001044720
NM_011511
NM_021041
NM_021042
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr18_+_23656024 11.490 Dtna
dystrobrevin alpha
chr3_+_5218545 11.488 NM_030708
Zfhx4
zinc finger homeodomain 4
chr4_-_147016606 11.488 NM_145078
2610305D13Rik
RIKEN cDNA 2610305D13 gene
chr15_+_34167780 11.455 NM_033521
Laptm4b
lysosomal-associated protein transmembrane 4B
chr19_-_57083064 11.312 NM_001177796
NM_001177797
NM_146102
Afap1l2


actin filament associated protein 1-like 2


chr1_+_45368443 11.307 Col3a1
collagen, type III, alpha 1
chr19_+_54003803 11.300 Pdcd4
programmed cell death 4
chr4_+_145850602 11.260 NM_001177767
NM_009051
Gm13138
Rex2
predicted gene 13138
reduced expression 2
chr4_+_146395958 11.260 NM_001177767
NM_009051
Gm13138
Rex2
predicted gene 13138
reduced expression 2
chr2_+_91386476 11.259 NM_001165989
NM_029437
Ckap5

cytoskeleton associated protein 5

chr3_-_116671869 11.228 NM_023245
Palmd
palmdelphin
chr16_-_28753276 11.138 NM_010199
Fgf12
fibroblast growth factor 12
chr9_-_117161564 11.094 NM_001172122
NM_001172123
NM_001172124
NM_001172126
NM_178660
Rbms3




RNA binding motif, single stranded interacting protein




chr10_+_127759512 11.088 NM_019953
Cnpy2
canopy 2 homolog (zebrafish)
chr11_-_6333725 11.065 H2afv
H2A histone family, member V

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.16 2.11e-07 GO:0008152 metabolic process
1.18 8.55e-07 GO:0044237 cellular metabolic process
1.15 4.61e-04 GO:0044238 primary metabolic process
1.29 6.98e-04 GO:0048523 negative regulation of cellular process
1.27 1.06e-03 GO:0048519 negative regulation of biological process
1.23 1.74e-03 GO:0007275 multicellular organismal development
1.24 1.87e-03 GO:0048856 anatomical structure development
1.21 2.83e-03 GO:0032502 developmental process
1.24 3.17e-03 GO:0006810 transport
1.65 3.83e-03 GO:0000902 cell morphogenesis
1.25 4.15e-03 GO:0048731 system development
1.23 4.20e-03 GO:0051234 establishment of localization
1.51 6.32e-03 GO:0042180 cellular ketone metabolic process
1.60 7.60e-03 GO:0032989 cellular component morphogenesis
1.34 8.66e-03 GO:0009653 anatomical structure morphogenesis
2.91 9.63e-03 GO:0050808 synapse organization
1.30 1.14e-02 GO:0044281 small molecule metabolic process
1.20 1.48e-02 GO:0051179 localization
1.28 1.49e-02 GO:0065008 regulation of biological quality
1.49 1.52e-02 GO:0006082 organic acid metabolic process
1.34 1.58e-02 GO:0009056 catabolic process
1.49 2.28e-02 GO:0019752 carboxylic acid metabolic process
1.49 2.28e-02 GO:0043436 oxoacid metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.21 4.84e-17 GO:0005737 cytoplasm
1.28 1.94e-16 GO:0044444 cytoplasmic part
1.16 6.64e-16 GO:0044424 intracellular part
1.15 9.31e-15 GO:0005622 intracellular
1.17 5.80e-14 GO:0043226 organelle
1.17 1.06e-13 GO:0043229 intracellular organelle
1.18 2.46e-12 GO:0043227 membrane-bounded organelle
1.18 4.58e-12 GO:0043231 intracellular membrane-bounded organelle
1.54 4.73e-12 GO:0005739 mitochondrion
1.58 1.32e-10 GO:0000267 cell fraction
1.61 8.28e-09 GO:0005626 insoluble fraction
1.51 1.65e-08 GO:0031090 organelle membrane
1.61 2.01e-08 GO:0005624 membrane fraction
1.23 3.13e-07 GO:0044422 organelle part
1.23 4.83e-07 GO:0044446 intracellular organelle part
1.73 4.91e-07 GO:0044429 mitochondrial part
1.83 8.63e-07 GO:0031966 mitochondrial membrane
1.79 2.08e-06 GO:0005740 mitochondrial envelope
1.63 6.46e-06 GO:0031967 organelle envelope
1.60 1.60e-05 GO:0031975 envelope
1.23 2.70e-05 GO:0032991 macromolecular complex
1.43 7.89e-05 GO:0005783 endoplasmic reticulum
1.45 1.33e-04 GO:0005794 Golgi apparatus
1.51 2.06e-04 GO:0005615 extracellular space
1.78 3.18e-04 GO:0005743 mitochondrial inner membrane
1.73 6.20e-04 GO:0019866 organelle inner membrane
1.55 6.60e-04 GO:0043005 neuron projection
1.22 1.40e-03 GO:0043234 protein complex
1.74 1.43e-03 GO:0044432 endoplasmic reticulum part
1.39 2.37e-03 GO:0044421 extracellular region part
1.77 3.13e-03 GO:0005789 endoplasmic reticulum membrane
1.75 3.30e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.36 3.75e-03 GO:0042995 cell projection
1.53 7.75e-03 GO:0045202 synapse
1.40 1.08e-02 GO:0012505 endomembrane system
1.59 1.96e-02 GO:0005625 soluble fraction
1.27 2.67e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.14 7.41e-13 GO:0005488 binding
1.23 9.15e-11 GO:0005515 protein binding
1.24 1.19e-02 GO:0000166 nucleotide binding