Motif ID: GATA6.p2

Z-value: 3.262


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
Gata6 14465 GATA binding protein 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata6chr18_+_110524640.264.1e-04Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_133558507 64.206 Ctse
cathepsin E
chr1_+_133558486 64.059 Ctse
cathepsin E
chr1_+_133558517 62.189 Ctse
cathepsin E
chr4_-_46416895 56.542 Hemgn
hemogen
chr3_-_14808320 56.106 NM_009799
Car1
carbonic anhydrase 1
chr1_+_133535033 52.495 Ctse
cathepsin E
chr6_+_68375560 51.042 Igkv16-104
immunoglobulin kappa variable 16-104
chr4_-_46417054 47.908 NM_053149
Hemgn
hemogen
chr6_+_30589440 47.145 Cpa1
carboxypeptidase A1
chr6_+_41252267 47.025 NM_011646
Try4
trypsin 4
chr3_-_20142068 43.742 NM_007753
Cpa3
carboxypeptidase A3, mast cell
chr8_+_87225355 40.830 NM_008535
Lyl1
lymphoblastomic leukemia 1
chr6_+_67966702 39.079


chr17_-_28697643 36.639 NM_025469
Clps
colipase, pancreatic
chrX_+_146981989 35.842 Alas2
aminolevulinic acid synthase 2, erythroid
chrX_+_146981959 34.548 NM_001102446
NM_009653
Alas2

aminolevulinic acid synthase 2, erythroid

chr6_+_30589217 33.376 NM_025350
Cpa1
carboxypeptidase A1
chr19_+_58744854 33.224 NM_026925
Pnlip
pancreatic lipase
chr4_-_141381906 32.451 NM_007919
Cela2a
chymotrypsin-like elastase family, member 2A
chr11_+_95198329 31.793 NM_172543
Fam117a
family with sequence similarity 117, memberA
chr4_-_136965705 31.719 NM_001126318
Gm13011
predicted gene 13011
chr19_+_58803376 31.692 NM_018874
Pnliprp1
pancreatic lipase related protein 1
chr11_+_70452623 31.110 NM_010326
Gp1ba
glycoprotein 1b, alpha polypeptide
chr17_-_26335980 31.080 NM_001081070
Pdia2
protein disulfide isomerase associated 2
chr11_-_106243873 30.904 NM_010494
Icam2
intercellular adhesion molecule 2
chr6_-_41654290 30.415 NM_032540
Kel
Kell blood group
chr8_+_87225390 30.080 Lyl1
lymphoblastomic leukemia 1
chr6_+_70676428 29.794


chr8_-_87904870 29.444 Mylk3
myosin light chain kinase 3
chr6_+_125502979 28.668 NM_011708
Vwf
Von Willebrand factor homolog
chr4_-_118862555 28.464 NM_013848
Ermap
erythroblast membrane-associated protein
chr15_-_102062331 27.109 NM_013566
Itgb7
integrin beta 7
chr15_-_102062309 27.025 Itgb7
integrin beta 7
chr11_+_72812583 26.921 NM_008771
P2rx1
purinergic receptor P2X, ligand-gated ion channel, 1
chr8_+_87425826 26.732 NM_010635
Klf1
Kruppel-like factor 1 (erythroid)
chr2_+_103798150 26.724 NM_001142337
Lmo2
LIM domain only 2
chr5_+_115916274 26.309 NM_011107
Pla2g1b
phospholipase A2, group IB, pancreas
chr8_-_87889165 26.226 NM_175441
Mylk3
myosin light chain kinase 3
chr7_-_142720274 26.169 NM_178669
Clrn3
clarin 3
chr1_-_175157322 25.139 NM_010184
Fcer1a
Fc receptor, IgE, high affinity I, alpha polypeptide
chr11_+_87569075 24.997 A430104N18Rik
RIKEN cDNA A430104N18 gene
chr4_-_136986432 24.814 NM_026419
Cela3b
chymotrypsin-like elastase family, member 3B
chr6_-_40985505 24.287 NM_023333
2210010C04Rik
RIKEN cDNA 2210010C04 gene
chr9_+_20833816 23.843 NM_023892
Icam4
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr19_-_7093834 23.826 Fermt3
fermitin family homolog 3 (Drosophila)
chr4_+_40867085 23.710 NM_011463
Spink4
serine peptidase inhibitor, Kazal type 4
chr11_-_102331042 23.487 NM_010575
Itga2b
integrin alpha 2b
chr6_+_41304103 22.776 NM_001038996
Try10
trypsin 10
chr3_+_122598292 22.421 NM_007980
Fabp2
fatty acid binding protein 2, intestinal
chr17_+_37006518 22.149 NM_011280
Trim10
tripartite motif-containing 10
chr4_+_133109291 21.789 NM_011850
Nr0b2
nuclear receptor subfamily 0, group B, member 2
chr1_+_176102903 21.289 NM_011465
Spna1
spectrin alpha 1
chr4_+_119310319 21.092 NM_008190
Guca2a
guanylate cyclase activator 2a (guanylin)
chr19_+_20676453 21.044 NM_013467
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr19_-_7093919 20.476 NM_153795
Fermt3
fermitin family homolog 3 (Drosophila)
chr7_-_126602780 20.151 NM_025989
Gp2
glycoprotein 2 (zymogen granule membrane)
chr17_-_85082309 20.049 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr9_+_46036788 20.049 Apoa1
apolipoprotein A-I
chr17_-_85082214 19.847 NM_031884
Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr9_+_46036703 19.226 NM_009692
Apoa1
apolipoprotein A-I
chr17_+_71553920 18.822 NM_001164885
Lpin2
lipin 2
chr9_+_46036799 18.781 Apoa1
apolipoprotein A-I
chr2_+_84820615 18.756 NM_008920
Prg2
proteoglycan 2, bone marrow
chr6_+_145070255 18.418 NM_008511
Lrmp
lymphoid-restricted membrane protein
chr7_+_29618812 17.914 NM_010706
Lgals4
Lgals6
lectin, galactose binding, soluble 4
lectin, galactose binding, soluble 6
chr7_-_139978601 17.651 NM_175268
Fam53b
family with sequence similarity 53, member B
chr9_-_99617685 17.573 NM_001194921
NM_001194923
Cldn18

claudin 18

chr6_-_70067577 17.507 Gm10883
predicted gene 10883
chr18_-_78320126 17.345 NM_001171010
NM_028122
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr16_-_19983049 17.340 NM_183390
Klhl6
kelch-like 6 (Drosophila)
chr1_-_140071630 17.073 Ptprc
protein tyrosine phosphatase, receptor type, C
chr17_+_71554015 17.035 Lpin2
lipin 2
chr16_+_38362258 16.917 NM_001081984
NM_022318
Popdc2

popeye domain containing 2

chr19_+_25127069 16.878 Dock8
dedicator of cytokinesis 8
chr1_+_175561105 16.789 Pyhin1
pyrin and HIN domain family, member 1
chr8_-_125222837 16.752 NM_009824
Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr4_-_63522069 16.575 NM_009403
Tnfsf8
tumor necrosis factor (ligand) superfamily, member 8
chr17_+_40948047 16.241 NM_011269
Rhag
Rhesus blood group-associated A glycoprotein
chr18_-_78320014 16.160 Slc14a1
solute carrier family 14 (urea transporter), member 1
chr16_-_95680888 16.104 Erg
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr7_-_4474044 15.831 NM_009406
Tnni3
troponin I, cardiac 3
chr1_-_146622545 15.733 NM_022881
Rgs18
regulator of G-protein signaling 18
chr4_+_134420419 15.688 NM_011270
Rhd
Rh blood group, D antigen
chr19_-_10752469 15.590 NM_021453
Pga5
pepsinogen 5, group I
chr9_-_21767872 15.266 NM_010149
Epor
erythropoietin receptor
chr16_+_44943790 15.198 NM_001128132
NM_001128133
NM_027578
NM_029018
Cd200r3



CD200 receptor 3



chr7_-_4473916 15.169 Tnni3
troponin I, cardiac 3
chr11_+_33946927 14.810 Lcp2
lymphocyte cytosolic protein 2
chr14_-_65074739 14.626 NM_026322
Msra
methionine sulfoxide reductase A
chr10_+_126437764 14.393 NM_009635
Avil
advillin
chr17_+_31345010 13.780 NM_177823
Ubash3a
ubiquitin associated and SH3 domain containing, A
chr14_-_118450875 13.482 NM_010024
Dct
dopachrome tautomerase
chr14_+_31699648 13.353 NM_001159299
NM_018746
Itih4

inter alpha-trypsin inhibitor, heavy chain 4

chr6_+_86578167 13.090 NM_026414
Asprv1
aspartic peptidase, retroviral-like 1
chr8_-_13396775 13.048 NM_009724
Atp4b
ATPase, H+/K+ exchanging, beta polypeptide
chr8_+_13037791 12.707 F10
coagulation factor X
chr13_-_62959656 12.688 NM_007994
Fbp2
fructose bisphosphatase 2
chr7_-_110976499 12.582 Hbb-b1
hemoglobin, beta adult major chain
chr6_-_41264706 12.570 NM_001003405
Try5
trypsin 5
chr1_-_138856866 12.303 NM_030676
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr3_-_106022381 12.241 NM_145126
Chi3l4
chitinase 3-like 4
chr6_-_87300891 12.239 NM_025466
Gkn1
gastrokine 1
chr18_+_20823750 12.238 NM_013697
Ttr
transthyretin
chr6_+_87728129 12.037 NM_018762
Gp9
glycoprotein 9 (platelet)
chr11_-_5798780 12.003 NM_022879
Myl7
myosin, light polypeptide 7, regulatory
chr9_+_107199019 11.953 NM_009895
Cish
cytokine inducible SH2-containing protein
chr11_+_115773273 11.647 NM_001162998
1110017F19Rik
RIKEN cDNA 1110017F19 gene
chr6_+_41342352 11.590 NM_001038997
Gm5771
predicted gene 5771
chr19_+_11822048 11.530 NM_008118
Gif
gastric intrinsic factor
chr9_-_44150387 11.473 NM_001110251
Hmbs
hydroxymethylbilane synthase
chr10_+_53057491 11.041 NM_001141927
NM_023129
Pln

phospholamban

chr1_-_69732373 10.979 NM_011770
Ikzf2
IKAROS family zinc finger 2
chr17_+_53723450 10.760 NM_001190846
Kat2b
K(lysine) acetyltransferase 2B
chr19_+_4083489 10.636 NM_001160252
NM_013878
Cabp2

calcium binding protein 2

chrX_-_98463514 10.405 NM_013563
Il2rg
interleukin 2 receptor, gamma chain
chr13_-_62959751 10.380 Fbp2
fructose bisphosphatase 2
chr1_-_140071818 10.258 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr7_+_29619155 10.256 NM_010707
Lgals4
Lgals6
lectin, galactose binding, soluble 4
lectin, galactose binding, soluble 6
chr14_-_51765134 10.225 Rnase1
ribonuclease, RNase A family, 1 (pancreatic)
chr2_+_112124767 10.197 NM_133648
Slc12a6
solute carrier family 12, member 6
chr3_+_105916283 10.169 NM_023186
Chia
chitinase, acidic
chr6_+_87323350 9.933 NM_025467
Gkn2
gastrokine 2
chr8_+_107257897 9.903 NM_001190330
NM_133960
Ces2a

carboxylesterase 2A

chr16_-_30310864 9.878 NM_008148
Gp5
glycoprotein 5 (platelet)
chr6_-_136806041 9.780 NM_026639
Art4
ADP-ribosyltransferase 4
chrX_+_9829439 9.749 NM_008769
Otc
ornithine transcarbamylase
chr11_-_99354449 9.729 Krt23
keratin 23
chr2_-_76820599 9.583 NM_011652
NM_028004
Ttn

titin

chr15_-_58220798 9.563 NM_027211
Anxa13
annexin A13
chr3_-_75073981 9.431 NM_026460
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr7_-_106387077 9.415 NM_177448
Mogat2
monoacylglycerol O-acyltransferase 2
chr7_-_54707508 9.397 NM_001172588
Mrgpra2b
Mrgpra2a
MAS-related GPR, member A2B
MAS-related GPR, member A2A
chr11_+_32176599 9.394 NM_010405
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_-_99354417 9.387 NM_033373
Krt23
keratin 23
chr17_+_85082504 9.115 Abcg8
ATP-binding cassette, sub-family G (WHITE), member 8
chr15_+_80453912 9.092 NM_010815
Grap2
GRB2-related adaptor protein 2
chr12_+_87027595 9.065 NM_016767
Batf
basic leucine zipper transcription factor, ATF-like
chr19_-_41289045 9.018 Tm9sf3
transmembrane 9 superfamily member 3
chr3_+_88940063 8.977 NM_013631
Pklr
pyruvate kinase liver and red blood cell
chr4_+_134483092 8.899


chr1_-_146024404 8.838 NM_153171
Rgs13
regulator of G-protein signaling 13
chr18_+_20823908 8.796 Ttr
transthyretin
chr9_+_99512920 8.790 NM_001077424
A4gnt
alpha-1,4-N-acetylglucosaminyltransferase
chr1_-_175263540 8.783 NM_010045
Darc
Duffy blood group, chemokine receptor
chr7_-_110976439 8.563 Hbb-b1
hemoglobin, beta adult major chain
chr13_-_73838142 8.524 NM_028878
Slc6a19
solute carrier family 6 (neurotransmitter transporter), member 19
chr9_-_39935623 8.397 NM_146855
Olfr985
olfactory receptor 985
chr12_+_105474449 8.358 Serpina3g
serine (or cysteine) peptidase inhibitor, clade A, member 3G
chr17_-_37712365 8.237 NM_146289
Olfr113
olfactory receptor 113
chr4_-_59451429 8.123 NM_001163288
Susd1
sushi domain containing 1
chr19_+_53966720 8.113 NM_011050
Pdcd4
programmed cell death 4
chr18_-_20273110 7.767 NM_013504
Dsc1
desmocollin 1
chr7_-_110976314 7.701 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr15_+_10930475 7.693 NM_053077
Slc45a2
solute carrier family 45, member 2
chr2_+_90958300 7.691 NM_008653
Mybpc3
myosin binding protein C, cardiac
chr6_+_86578225 7.643 Asprv1
aspartic peptidase, retroviral-like 1
chr1_-_65119965 7.575 NM_007775
NM_001082573
Crygc

crystallin, gamma C

chr17_+_85082489 7.571 Abcg8
ATP-binding cassette, sub-family G (WHITE), member 8
chr17_+_28960526 7.519 Brpf3
bromodomain and PHD finger containing, 3
chr17_-_29052264 7.465 NM_172450
4930539E08Rik
RIKEN cDNA 4930539E08 gene
chr19_-_39723518 7.450 NM_001024719
Cyp2c67
cytochrome P450, family 2, subfamily c, polypeptide 67
chr11_-_106257752 7.407 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr16_-_64786146 7.337 NM_028059
Zfp654
zinc finger protein 654
chr3_+_116562484 7.318 NM_001113478
Frrs1
ferric-chelate reductase 1
chr6_-_136730254 7.161 NM_001127318
NM_145067
Gucy2c

guanylate cyclase 2c

chr12_-_82069060 7.070 NM_001177561
NM_011387
Slc10a1

solute carrier family 10 (sodium/bile acid cotransporter family), member 1

chr10_-_116333934 7.008 NM_001033333
Gm239
predicted gene 239
chr2_-_25095376 6.947 NM_026415
2310002J15Rik
RIKEN cDNA 2310002J15 gene
chr14_-_69200119 6.934 NM_021475
Adamdec1
ADAM-like, decysin 1
chr11_+_70318775 6.918 NM_029360
Tm4sf5
transmembrane 4 superfamily member 5
chr2_-_129094163 6.915 Ckap2l
cytoskeleton associated protein 2-like
chr12_-_82068951 6.871 Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr19_+_27397077 6.859 NM_183179
Kcnv2
potassium channel, subfamily V, member 2
chr11_-_99712918 6.829 NM_001013823
Krtap4-16
keratin associated protein 4-16
chr11_+_79845841 6.803 Suz12
suppressor of zeste 12 homolog (Drosophila)
chr7_+_53339469 6.751


chr7_+_148876260 6.739 NM_023566
Muc2
mucin 2
chr5_+_91201521 6.682 Pf4
platelet factor 4
chr6_+_71149869 6.679 NM_017399
Fabp1
fatty acid binding protein 1, liver
chr15_-_24957039 6.664 Gm2824
predicted gene 2824
chr11_+_95885858 6.630 NM_008119
Gip
gastric inhibitory polypeptide
chr11_+_72904084 6.580 NM_008399
NM_172944
Itgae

integrin alpha E, epithelial-associated

chr17_-_25482323 6.547 NM_031187
Tpsab1
tryptase alpha/beta 1
chr2_-_6642489 6.431 Celf2
CUGBP, Elav-like family member 2
chr11_+_32183671 6.376 NM_001083955
NM_008218
Hba-a2
Hba-a1
hemoglobin alpha, adult chain 2
hemoglobin alpha, adult chain 1
chr3_+_105707338 6.367 NM_009631
Adora3
adenosine A3 receptor
chr17_+_85082470 6.342 NM_026180
Abcg8
ATP-binding cassette, sub-family G (WHITE), member 8
chr8_+_35178083 6.246 NM_001126314
Mboat4
membrane bound O-acyltransferase domain containing 4
chr5_-_141476549 6.147 NM_175362
Card11
caspase recruitment domain family, member 11
chr16_+_36935029 6.136 NM_008225
Hcls1
hematopoietic cell specific Lyn substrate 1
chr19_+_12873115 6.127 Lpxn
leupaxin
chr19_-_34673889 6.119 NM_001110517
Gm14446
predicted gene 14446
chr5_-_122286849 6.099 Sh2b3
SH2B adaptor protein 3
chr1_+_89700245 6.025 NM_009118
Sag
retinal S-antigen
chr7_-_111161213 5.969 NM_147084
Olfr639
olfactory receptor 639
chr9_-_77391865 5.943 NM_172528
Lrrc1
leucine rich repeat containing 1
chr5_+_86500770 5.826 NM_019992
Stap1
signal transducing adaptor family member 1
chr1_+_6720153 5.682 St18
suppression of tumorigenicity 18
chr3_-_37024751 5.677 NM_008366
Il2
interleukin 2
chr6_-_129225348 5.637 NM_001033122
Cd69
CD69 antigen

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.90 5.87e-04 GO:0007586 digestion
3.09 1.06e-03 GO:0030097 hemopoiesis
14.22 3.04e-03 GO:0050892 intestinal absorption
2.70 7.54e-03 GO:0002520 immune system development
2.74 9.33e-03 GO:0048534 hemopoietic or lymphoid organ development
1.95 1.32e-02 GO:0002376 immune system process
4.83 2.52e-02 GO:0007596 blood coagulation
4.83 2.52e-02 GO:0050817 coagulation
4.77 2.83e-02 GO:0007599 hemostasis
7.54 4.75e-02 GO:0002712 regulation of B cell mediated immunity
7.54 4.75e-02 GO:0002889 regulation of immunoglobulin mediated immune response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.97 2.37e-08 GO:0005576 extracellular region
11.85 9.69e-03 GO:0031672 A band
3.42 2.69e-02 GO:0005882 intermediate filament

Nothing significant found in function category.