Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 2.587


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
Hbp1 73389 high mobility group box transcription factor 1
Hmgb2 97165 high mobility group box 2
Hmgb3 15354 high mobility group box 3
Ssrp1 20833 structure specific recognition protein 1
Ubtf 21429 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmgb2chr8_+_59990639-0.485.6e-12Click!
Ssrp1chr2_+_84877325-0.358.9e-07Click!
Hmgb3chrX_+_688091280.241.2e-03Click!
Ubtfchr11_-_102180258,
chr11_-_102178941,
chr11_-_102178559,
chr11_-_102180282
-0.163.2e-02Click!
Hbp1chr12_-_32635399-0.138.3e-02Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_34548512 68.496 Cald1
caldesmon 1
chr8_-_87297283 57.839 Nfix
nuclear factor I/X
chr2_-_84614960 57.230 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr3_+_137004089 56.151 Emcn
endomucin
chr3_+_137004041 54.654 NM_001163522
NM_016885
Emcn

endomucin

chr16_+_43619057 54.469 Zbtb20
zinc finger and BTB domain containing 20
chr4_-_75779379 52.199 NM_001014288
Ptprd
protein tyrosine phosphatase, receptor type, D
chr1_+_45390415 51.725 Col3a1
collagen, type III, alpha 1
chr16_+_35002066 50.435 Mylk
myosin, light polypeptide kinase
chr3_-_57651621 50.184 NM_019410
Pfn2
profilin 2
chr8_-_11312686 50.161 Col4a1
collagen, type IV, alpha 1
chr4_-_76240202 48.405 NM_011211
Ptprd
protein tyrosine phosphatase, receptor type, D
chr9_-_117539030 47.932 NM_001172121
Rbms3
RNA binding motif, single stranded interacting protein
chr2_-_84615535 47.051 NM_009776
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr6_-_87285690 46.194 NM_054041
Antxr1
anthrax toxin receptor 1
chr4_-_82150687 45.898 Nfib
nuclear factor I/B
chr4_-_82151590 44.976 Nfib
nuclear factor I/B
chr14_-_122097583 44.374 NM_001081039
Dock9
dedicator of cytokinesis 9
chrX_+_54032914 43.281 Fhl1
four and a half LIM domains 1
chr4_-_82151004 42.906 Nfib
nuclear factor I/B
chr18_+_69753035 42.901 Tcf4
transcription factor 4
chr10_+_56097078 42.648 NM_010288
Gja1
gap junction protein, alpha 1
chr11_-_118162557 42.645


chrX_+_162782484 42.189 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
Gpm6b





glycoprotein m6b





chr1_+_12708582 40.805 NM_172294
Sulf1
sulfatase 1
chr8_+_11313002 40.726 Col4a2
collagen, type IV, alpha 2
chr12_-_103057112 40.372 Fbln5
fibulin 5
chr1_-_166368439 40.213 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr8_-_49760037 39.873 NM_001145937
NM_011857
Odz3

odd Oz/ten-m homolog 3 (Drosophila)

chr12_-_103056971 39.816 Fbln5
fibulin 5
chr18_-_43552694 39.608 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr9_-_49311823 37.657 Ncam1
neural cell adhesion molecule 1
chr9_-_49607164 36.391 NM_001081445
NM_001113204
NM_010875
Ncam1


neural cell adhesion molecule 1


chr6_+_34659440 34.914 NM_145575
Cald1
caldesmon 1
chr11_+_28767772 34.080 Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr8_+_11312828 33.923 NM_009932
Col4a2
collagen, type IV, alpha 2
chr3_+_121160714 33.085 Cnn3
calponin 3, acidic
chr18_+_37644674 33.052 NM_053142
Pcdhb17
protocadherin beta 17
chr10_-_8605668 32.804 NM_175155
Sash1
SAM and SH3 domain containing 1
chr1_-_82232392 32.144 Irs1
insulin receptor substrate 1
chr7_+_138087002 31.577 Htra1
HtrA serine peptidase 1
chr10_+_96942181 31.434 Dcn
decorin
chr7_-_77505248 31.137 NM_009697
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr9_-_117161564 31.091 NM_001172122
NM_001172123
NM_001172124
NM_001172126
NM_178660
Rbms3




RNA binding motif, single stranded interacting protein




chr10_+_69388242 31.078 NM_009670
NM_170687
Ank3

ankyrin 3, epithelial

chr4_-_82151180 30.814 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr4_-_82151657 30.759 Nfib
nuclear factor I/B
chr18_+_69753146 30.687 Tcf4
transcription factor 4
chr1_+_137625754 30.439 NM_007791
Csrp1
cysteine and glycine-rich protein 1
chr10_+_96942124 30.399 NM_001190451
Dcn
decorin
chr16_+_45094214 30.356 Ccdc80
coiled-coil domain containing 80
chr16_+_45094196 30.203 Ccdc80
coiled-coil domain containing 80
chr19_+_23241546 29.980 Klf9
Kruppel-like factor 9
chr16_-_18622083 28.995


chr8_+_91116225 28.935 Nkd1
naked cuticle 1 homolog (Drosophila)
chr1_+_137635977 28.853 Csrp1
cysteine and glycine-rich protein 1
chr3_+_121129588 28.789 Cnn3
calponin 3, acidic
chr2_-_170232008 28.719 Bcas1
breast carcinoma amplified sequence 1
chr15_+_98465193 28.254 NM_007581
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr11_-_20729367 27.851 1110067D22Rik
RIKEN cDNA 1110067D22 gene
chr8_+_46593141 27.667 NM_172752
Sorbs2
sorbin and SH3 domain containing 2
chrX_-_149078963 27.211 Shroom2
shroom family member 2
chr12_+_110783786 27.210 Meg3
maternally expressed 3
chr16_+_45094163 27.148 NM_026439
Ccdc80
coiled-coil domain containing 80
chr3_-_113277601 26.838 NM_007446
Amy1
amylase 1, salivary
chr10_+_61245998 26.627


chr16_-_28929698 26.582 NM_177718
1600021P15Rik
RIKEN cDNA 1600021P15 gene
chr3_+_34548916 26.395 NM_011443
Sox2
SRY-box containing gene 2
chr5_-_116858596 26.078


chr1_-_172018982 25.893 NM_022563
Ddr2
discoidin domain receptor family, member 2
chr8_+_56040445 25.855 Gpm6a
glycoprotein m6a
chr6_-_83486194 25.545 NM_009610
Actg2
actin, gamma 2, smooth muscle, enteric
chr13_-_60278723 25.374 Gas1
growth arrest specific 1
chr8_+_56040553 25.159 Gpm6a
glycoprotein m6a
chr6_+_4490515 24.848 Col1a2
collagen, type I, alpha 2
chr16_+_34995000 24.774 Mylk
myosin, light polypeptide kinase
chr5_-_122907002 24.759 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr2_-_84614976 24.730 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr13_-_60278859 24.586 NM_008086
Gas1
growth arrest specific 1
chr16_+_92086695 24.572 Slc5a3
solute carrier family 5 (inositol transporters), member 3
chr7_+_69493148 24.290 NM_010882
Ndn
necdin
chr6_+_30758582 24.288 Copg2as2
coatomer protein complex, subunit gamma 2, antisense 2
chr9_-_91255831 24.245 Zic1
zinc finger protein of the cerebellum 1
chr19_-_55177562 24.194 Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
chr8_-_42140113 24.085 NM_001005864
Mtus1
mitochondrial tumor suppressor 1
chr4_-_60594959 24.060 NM_001122647
Mup10
LOC100048884
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 1
chr12_+_110783593 23.951 Meg3
maternally expressed 3
chr5_-_51848420 23.790 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chrX_+_10173557 23.691


chr9_-_63869857 23.618 NM_008542
Smad6
MAD homolog 6 (Drosophila)
chrX_+_130829763 23.563 NM_026239
Tmem35
transmembrane protein 35
chr18_-_33623400 23.541 NM_001109989
D0H4S114
DNA segment, human D4S114
chr12_+_76409299 23.455 NM_023275
Rhoj
ras homolog gene family, member J
chr13_+_109444370 23.407 NM_011056
Pde4d
phosphodiesterase 4D, cAMP specific
chr6_+_4484651 23.350 Col1a2
collagen, type I, alpha 2
chr16_+_7409879 23.048 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr15_+_98465328 23.038 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chrX_+_130829929 22.884 Tmem35
transmembrane protein 35
chr7_-_89079168 22.799 Hdgfrp3
hepatoma-derived growth factor, related protein 3
chr4_+_104829963 22.718 Ppap2b
phosphatidic acid phosphatase type 2B
chr1_-_170085342 22.669 Pbx1
pre B-cell leukemia transcription factor 1
chr12_+_30622876 22.330 NM_181395
Pxdn
peroxidasin homolog (Drosophila)
chr1_+_51345952 22.293 NM_138741
Sdpr
serum deprivation response
chr8_-_11312729 22.180 NM_009931
Col4a1
collagen, type IV, alpha 1
chr4_-_117881591 22.159 Ptprf
protein tyrosine phosphatase, receptor type, F
chrX_+_93651684 21.997 NM_001159627
NM_181273
Heph

hephaestin

chr2_+_125860377 21.907 NM_008008
Fgf7
fibroblast growth factor 7
chr2_+_35516774 21.853 Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr8_-_37631772 21.820 Dlc1
deleted in liver cancer 1
chr4_+_55093796 21.776 Zfp462
zinc finger protein 462
chr18_+_37901716 21.664 NM_033578
Pcdhgb6
protocadherin gamma subfamily B, 6
chr18_+_37644390 21.575 Pcdhb17
protocadherin beta 17
chr18_-_33623287 21.441 NM_053078
D0H4S114
DNA segment, human D4S114
chr2_-_173053287 21.394 Pmepa1
prostate transmembrane protein, androgen induced 1
chr1_+_51346086 21.346 Sdpr
serum deprivation response
chr4_+_104829951 21.130 NM_080555
Ppap2b
phosphatidic acid phosphatase type 2B
chr12_+_118896501 21.083 Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr8_-_48373564 20.872 Stox2
storkhead box 2
chr8_-_25549374 20.757 1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr6_+_122463595 20.738 Mfap5
microfibrillar associated protein 5
chr18_+_37911236 20.624 NM_033579
Pcdhgb7
protocadherin gamma subfamily B, 7
chr3_-_145312928 20.505 NM_010516
Cyr61
cysteine rich protein 61
chr9_+_95538150 20.478 Pcolce2
procollagen C-endopeptidase enhancer 2
chr9_-_30978164 20.394 Aplp2
amyloid beta (A4) precursor-like protein 2
chr8_-_25549415 20.314 NM_026931
1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr1_-_170085798 20.128 Pbx1
pre B-cell leukemia transcription factor 1
chr2_+_125860507 20.021 Fgf7
fibroblast growth factor 7
chr1_-_176851949 19.976 NM_011825
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr9_+_74823917 19.844 NM_153584
BC031353
cDNA sequence BC031353
chr10_+_68996455 19.767 NM_146005
NM_170688
NM_170689
NM_170690
NM_170728
NM_170729
NM_170730
Ank3






ankyrin 3, epithelial






chr14_+_121434765 19.756 NM_134082
Farp1
FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
chr15_-_58046380 19.678 Fbxo32
F-box protein 32
chr9_+_95538038 19.652 NM_029620
Pcolce2
procollagen C-endopeptidase enhancer 2
chr11_-_106576585 19.639 NM_001032378
NM_008816
Pecam1

platelet/endothelial cell adhesion molecule 1

chr11_-_22185840 19.528 NM_153078
Ehbp1
EH domain binding protein 1
chr1_-_194677940 19.336 NM_001177794
Sertad4
SERTA domain containing 4
chr14_+_29318658 19.311 NM_009524
Wnt5a
wingless-related MMTV integration site 5A
chr3_+_121129502 19.267 Cnn3
calponin 3, acidic
chr18_+_37120093 19.209 NM_009959
Pcdha5
protocadherin alpha 5
chr19_+_27292039 19.121 Vldlr
very low density lipoprotein receptor
chr12_-_15822792 18.983 Trib2
tribbles homolog 2 (Drosophila)
chr9_+_21903702 18.935 Cnn1
calponin 1
chr11_-_118163704 18.925 Timp2
tissue inhibitor of metalloproteinase 2
chr11_-_106576550 18.923 Pecam1
platelet/endothelial cell adhesion molecule 1
chr18_+_37157533 18.909 NM_138661
Pcdha9
protocadherin alpha 9
chr11_-_3439172 18.860 NM_001159284
NM_013870
Smtn

smoothelin

chrX_+_139952975 18.847 NM_001195048
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr3_-_83967952 18.625 Trim2
tripartite motif-containing 2
chr14_+_102237708 18.469 Lmo7
LIM domain only 7
chr18_-_16967754 18.446 Cdh2
cadherin 2
chr18_-_43219062 18.371 NM_028392
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr4_+_104829867 18.355 Ppap2b
phosphatidic acid phosphatase type 2B
chr5_-_122906470 18.320 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr2_-_140485267 18.297 Flrt3
fibronectin leucine rich transmembrane protein 3
chr9_+_45178521 18.287 Fxyd6
FXYD domain-containing ion transport regulator 6
chr18_+_37921454 18.138 NM_033580
Pcdhgb8
protocadherin gamma subfamily B, 8
chr18_+_37112301 18.123 NM_001174154
NM_007766
Pcdha4-g
Pcdha4
protocadherin alpha 4-gamma
protocadherin alpha 4
chr3_+_7366586 18.033 NM_008862
Pkia
protein kinase inhibitor, alpha
chr9_-_49607017 17.966 Ncam1
neural cell adhesion molecule 1
chr3_+_101180976 17.960 NM_207205
Igsf3
immunoglobulin superfamily, member 3
chr7_-_89079335 17.941 NM_013886
Hdgfrp3
hepatoma-derived growth factor, related protein 3
chr8_-_37631532 17.911 Dlc1
deleted in liver cancer 1
chr15_+_101933364 17.910 NM_153533
Tenc1
tensin like C1 domain-containing phosphatase
chr10_+_115738429 17.686 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr14_+_47621014 17.646 NM_001163433
Samd4
sterile alpha motif domain containing 4
chr6_-_92656148 17.626 NM_001081146
Prickle2
prickle homolog 2 (Drosophila)
chr9_+_50561092 17.593 Cryab
crystallin, alpha B
chr16_+_45094383 17.497 Ccdc80
coiled-coil domain containing 80
chr8_-_87298118 17.459 NM_001081981
Nfix
nuclear factor I/X
chr3_+_137940628 17.445 Adh1
alcohol dehydrogenase 1 (class I)
chr8_-_87323958 17.439 Nfix
nuclear factor I/X
chr11_-_106576380 17.355 Pecam1
platelet/endothelial cell adhesion molecule 1
chr9_+_45178485 17.349 Fxyd6
FXYD domain-containing ion transport regulator 6
chrX_+_54032858 17.336 NM_001077362
Fhl1
four and a half LIM domains 1
chr14_+_102239673 17.321 Lmo7
LIM domain only 7
chr8_+_56040193 17.195 Gpm6a
glycoprotein m6a
chr9_+_21903696 17.170 NM_009922
Cnn1
calponin 1
chr1_+_9591550 17.138 3110035E14Rik
RIKEN cDNA 3110035E14 gene
chr8_+_91115856 17.041 Nkd1
naked cuticle 1 homolog (Drosophila)
chr11_-_106576464 16.784 Pecam1
platelet/endothelial cell adhesion molecule 1
chr15_-_58046428 16.765 NM_026346
Fbxo32
F-box protein 32
chr6_+_71657791 16.760 NM_178608
Reep1
receptor accessory protein 1
chr15_+_101974616 16.735 NM_008344
Igfbp6
insulin-like growth factor binding protein 6
chr17_-_25218058 16.630 NM_001001183
Tmem204
transmembrane protein 204
chr4_+_94406190 16.564 Tek
endothelial-specific receptor tyrosine kinase
chr17_-_25218117 16.540 Tmem204
transmembrane protein 204
chr10_-_75261240 16.531 NM_008185
Gstt1
glutathione S-transferase, theta 1
chr4_+_104830022 16.495 Ppap2b
phosphatidic acid phosphatase type 2B
chr8_-_87296172 16.491 Nfix
nuclear factor I/X
chr3_+_67696141 16.475 NM_001113419
NM_177585
Iqcj-schip1
Iqcj
IQ motif containing J-schwannomin interacting protein 1 read-through transcript
IQ motif containing J
chr6_+_17256383 16.413 Cav1
caveolin 1, caveolae protein
chr9_+_92502076 16.358


chr11_+_28753190 16.358 NM_146015
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr12_+_41172639 16.356 NM_172803
Dock4
dedicator of cytokinesis 4
chr12_-_106003060 16.307 Clmn
calmin
chr8_-_87323896 16.284 Nfix
nuclear factor I/X
chr2_-_62411970 16.249 NM_007986
Fap
fibroblast activation protein
chr6_+_122463663 16.222 NM_015776
Mfap5
microfibrillar associated protein 5
chr7_+_137836057 16.088 NM_021314
Tacc2
transforming, acidic coiled-coil containing protein 2
chr1_-_135817945 16.063 NM_054077
Prelp
proline arginine-rich end leucine-rich repeat

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.81 9.19e-32 GO:0048856 anatomical structure development
1.87 1.04e-31 GO:0048731 system development
1.72 1.91e-31 GO:0032502 developmental process
1.76 1.91e-31 GO:0007275 multicellular organismal development
2.02 3.59e-22 GO:0009653 anatomical structure morphogenesis
2.02 1.82e-18 GO:0007399 nervous system development
2.36 8.45e-16 GO:0007155 cell adhesion
1.69 1.10e-15 GO:0030154 cell differentiation
2.34 1.71e-15 GO:0022610 biological adhesion
1.67 4.67e-15 GO:0048869 cellular developmental process
2.10 2.74e-14 GO:0022008 neurogenesis
1.57 2.75e-14 GO:0048522 positive regulation of cellular process
1.70 2.90e-14 GO:0048513 organ development
2.13 5.59e-14 GO:0048699 generation of neurons
1.53 6.88e-14 GO:0048518 positive regulation of biological process
1.62 9.42e-14 GO:0048523 negative regulation of cellular process
2.05 1.66e-13 GO:0048468 cell development
1.50 9.63e-13 GO:0016043 cellular component organization
1.56 1.77e-12 GO:0048519 negative regulation of biological process
1.59 2.28e-12 GO:0071842 cellular component organization at cellular level
2.30 1.09e-11 GO:0072358 cardiovascular system development
2.30 1.09e-11 GO:0072359 circulatory system development
1.95 1.36e-11 GO:0009888 tissue development
1.96 1.53e-11 GO:2000026 regulation of multicellular organismal development
2.65 2.11e-11 GO:0031175 neuron projection development
1.46 2.82e-11 GO:0071840 cellular component organization or biogenesis
2.41 6.87e-11 GO:0048666 neuron development
1.54 8.99e-11 GO:0071841 cellular component organization or biogenesis at cellular level
1.98 1.86e-10 GO:0045595 regulation of cell differentiation
2.20 2.04e-10 GO:0030182 neuron differentiation
1.83 2.15e-10 GO:0050793 regulation of developmental process
2.79 4.96e-10 GO:0048812 neuron projection morphogenesis
2.26 5.50e-10 GO:0032989 cellular component morphogenesis
1.39 7.69e-10 GO:0031323 regulation of cellular metabolic process
2.58 1.10e-09 GO:0048858 cell projection morphogenesis
2.35 1.51e-09 GO:0060284 regulation of cell development
2.88 2.04e-09 GO:0007409 axonogenesis
2.52 2.90e-09 GO:0032990 cell part morphogenesis
2.72 8.98e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
2.24 1.14e-08 GO:0000902 cell morphogenesis
2.49 1.22e-08 GO:0000904 cell morphogenesis involved in differentiation
2.45 1.37e-08 GO:0001944 vasculature development
2.15 1.66e-08 GO:0030030 cell projection organization
1.61 2.38e-08 GO:0051239 regulation of multicellular organismal process
1.33 2.71e-08 GO:0019222 regulation of metabolic process
2.62 3.18e-08 GO:0061061 muscle structure development
2.46 6.02e-08 GO:0001568 blood vessel development
2.27 6.43e-08 GO:0051093 negative regulation of developmental process
2.52 7.32e-08 GO:0001501 skeletal system development
2.70 7.66e-08 GO:0051129 negative regulation of cellular component organization
1.36 8.08e-08 GO:0060255 regulation of macromolecule metabolic process
1.59 1.93e-07 GO:0023051 regulation of signaling
1.81 2.30e-07 GO:0009790 embryo development
1.81 2.38e-07 GO:0051128 regulation of cellular component organization
1.34 2.87e-07 GO:0080090 regulation of primary metabolic process
1.93 4.04e-07 GO:0009887 organ morphogenesis
2.35 4.69e-07 GO:0045596 negative regulation of cell differentiation
1.94 7.20e-07 GO:0040011 locomotion
3.62 7.28e-07 GO:0048706 embryonic skeletal system development
1.40 7.52e-07 GO:0010468 regulation of gene expression
1.99 1.52e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.40 1.90e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.26 1.96e-06 GO:0050767 regulation of neurogenesis
2.19 2.62e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.34 3.17e-06 GO:0051179 localization
1.17 3.40e-06 GO:0065007 biological regulation
1.61 3.41e-06 GO:0009966 regulation of signal transduction
2.37 3.51e-06 GO:0045664 regulation of neuron differentiation
1.98 3.56e-06 GO:0009792 embryo development ending in birth or egg hatching
2.91 3.65e-06 GO:0042692 muscle cell differentiation
1.98 3.99e-06 GO:0043009 chordate embryonic development
1.41 4.28e-06 GO:0051252 regulation of RNA metabolic process
1.37 4.57e-06 GO:0031326 regulation of cellular biosynthetic process
1.94 6.24e-06 GO:0051094 positive regulation of developmental process
1.81 6.72e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.38 6.97e-06 GO:0010556 regulation of macromolecule biosynthetic process
1.36 7.76e-06 GO:0009889 regulation of biosynthetic process
1.36 1.05e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.36 1.20e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.68 1.48e-05 GO:0042127 regulation of cell proliferation
1.77 1.49e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.99 2.22e-05 GO:0007010 cytoskeleton organization
1.75 2.32e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.17 2.66e-05 GO:0050794 regulation of cellular process
2.08 3.02e-05 GO:0051960 regulation of nervous system development
1.16 3.58e-05 GO:0050789 regulation of biological process
2.41 3.60e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.07 3.77e-05 GO:0048729 tissue morphogenesis
1.63 4.06e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.72 4.34e-05 GO:0009890 negative regulation of biosynthetic process
1.61 4.78e-05 GO:0032879 regulation of localization
1.44 5.10e-05 GO:0065008 regulation of biological quality
2.79 5.20e-05 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.79 5.20e-05 GO:0022604 regulation of cell morphogenesis
5.00 6.11e-05 GO:0031110 regulation of microtubule polymerization or depolymerization
3.80 6.43e-05 GO:0051494 negative regulation of cytoskeleton organization
2.00 7.21e-05 GO:0060429 epithelium development
1.38 7.37e-05 GO:0006355 regulation of transcription, DNA-dependent
1.47 8.06e-05 GO:0048583 regulation of response to stimulus
2.04 8.96e-05 GO:0007389 pattern specification process
1.52 9.83e-05 GO:0031325 positive regulation of cellular metabolic process
2.03 9.97e-05 GO:0016477 cell migration
1.23 1.13e-04 GO:0032501 multicellular organismal process
3.69 1.18e-04 GO:0016202 regulation of striated muscle tissue development
3.02 1.34e-04 GO:0051146 striated muscle cell differentiation
3.43 1.42e-04 GO:0048638 regulation of developmental growth
3.00 1.66e-04 GO:0010639 negative regulation of organelle organization
1.60 1.82e-04 GO:0031324 negative regulation of cellular metabolic process
2.05 1.87e-04 GO:0022603 regulation of anatomical structure morphogenesis
2.09 2.02e-04 GO:0040012 regulation of locomotion
3.58 2.10e-04 GO:0048634 regulation of muscle organ development
1.49 2.11e-04 GO:0009893 positive regulation of metabolic process
2.28 2.20e-04 GO:0048514 blood vessel morphogenesis
6.70 2.32e-04 GO:0031113 regulation of microtubule polymerization
1.77 2.54e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.76 2.61e-04 GO:0051253 negative regulation of RNA metabolic process
1.56 2.79e-04 GO:0009892 negative regulation of metabolic process
2.08 3.12e-04 GO:0051270 regulation of cellular component movement
1.72 3.16e-04 GO:0010629 negative regulation of gene expression
1.91 3.36e-04 GO:0007417 central nervous system development
2.56 3.73e-04 GO:0060537 muscle tissue development
2.13 4.55e-04 GO:0030334 regulation of cell migration
1.57 4.67e-04 GO:0051641 cellular localization
1.55 4.80e-04 GO:0010646 regulation of cell communication
2.34 5.02e-04 GO:0016337 cell-cell adhesion
2.80 5.06e-04 GO:0007411 axon guidance
5.78 5.12e-04 GO:0031111 negative regulation of microtubule polymerization or depolymerization
2.10 7.21e-04 GO:2000145 regulation of cell motility
4.57 7.30e-04 GO:0010464 regulation of mesenchymal cell proliferation
1.88 8.18e-04 GO:0048598 embryonic morphogenesis
1.89 8.43e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.68 8.71e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.92 9.15e-04 GO:0045597 positive regulation of cell differentiation
2.34 9.68e-04 GO:0031344 regulation of cell projection organization
1.48 9.82e-04 GO:0010604 positive regulation of macromolecule metabolic process
2.00 1.02e-03 GO:0007420 brain development
1.56 1.05e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.71 1.06e-03 GO:0030323 respiratory tube development
2.45 1.12e-03 GO:0010975 regulation of neuron projection development
2.52 1.15e-03 GO:0050678 regulation of epithelial cell proliferation
1.93 1.16e-03 GO:0010627 regulation of intracellular protein kinase cascade
2.26 1.29e-03 GO:0001654 eye development
1.88 1.37e-03 GO:0048870 cell motility
1.88 1.37e-03 GO:0051674 localization of cell
1.67 1.51e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.53 1.59e-03 GO:0014706 striated muscle tissue development
2.19 1.64e-03 GO:0030029 actin filament-based process
2.08 1.90e-03 GO:0007507 heart development
2.39 2.03e-03 GO:0043062 extracellular structure organization
1.55 2.10e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.98 2.13e-03 GO:0035295 tube development
2.04 2.16e-03 GO:0033043 regulation of organelle organization
1.95 2.29e-03 GO:0007423 sensory organ development
2.66 2.48e-03 GO:0030324 lung development
2.61 2.55e-03 GO:0001503 ossification
1.62 2.56e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.72 2.72e-03 GO:0071844 cellular component assembly at cellular level
1.61 2.89e-03 GO:0051254 positive regulation of RNA metabolic process
1.83 2.92e-03 GO:0006928 cellular component movement
2.81 3.02e-03 GO:0051216 cartilage development
1.56 3.22e-03 GO:XXXXXXX unannotated
2.41 3.38e-03 GO:0007517 muscle organ development
1.53 3.43e-03 GO:0009891 positive regulation of biosynthetic process
1.77 3.62e-03 GO:0048585 negative regulation of response to stimulus
2.20 3.86e-03 GO:0030900 forebrain development
2.21 4.16e-03 GO:0043408 regulation of MAPKKK cascade
1.90 4.38e-03 GO:0008285 negative regulation of cell proliferation
1.17 4.52e-03 GO:0044237 cellular metabolic process
1.57 4.75e-03 GO:0010628 positive regulation of gene expression
2.18 4.93e-03 GO:0030036 actin cytoskeleton organization
1.16 5.09e-03 GO:0044238 primary metabolic process
1.38 5.12e-03 GO:0042221 response to chemical stimulus
1.56 5.41e-03 GO:0022607 cellular component assembly
2.26 5.84e-03 GO:0030155 regulation of cell adhesion
1.83 6.28e-03 GO:0007267 cell-cell signaling
3.58 6.65e-03 GO:0070507 regulation of microtubule cytoskeleton organization
2.59 6.76e-03 GO:0048736 appendage development
2.59 6.76e-03 GO:0060173 limb development
1.54 6.96e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
3.17 7.23e-03 GO:0048738 cardiac muscle tissue development
2.33 7.97e-03 GO:0051493 regulation of cytoskeleton organization
2.96 8.09e-03 GO:0050770 regulation of axonogenesis
2.36 8.36e-03 GO:0030855 epithelial cell differentiation
2.29 8.63e-03 GO:0001525 angiogenesis
2.04 9.52e-03 GO:0006935 chemotaxis
2.04 9.52e-03 GO:0042330 taxis
1.84 9.54e-03 GO:0009968 negative regulation of signal transduction
1.80 9.57e-03 GO:0023057 negative regulation of signaling
1.54 1.02e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.80 1.04e-02 GO:0010648 negative regulation of cell communication
4.30 1.05e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
2.58 1.10e-02 GO:0035107 appendage morphogenesis
2.58 1.10e-02 GO:0035108 limb morphogenesis
1.67 1.21e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.12 1.24e-02 GO:0048732 gland development
2.43 1.25e-02 GO:0060541 respiratory system development
2.02 1.31e-02 GO:0003002 regionalization
3.95 1.40e-02 GO:0043242 negative regulation of protein complex disassembly
3.04 1.43e-02 GO:0008016 regulation of heart contraction
1.79 1.51e-02 GO:0009719 response to endogenous stimulus
1.61 1.68e-02 GO:0019220 regulation of phosphate metabolic process
1.61 1.68e-02 GO:0051174 regulation of phosphorus metabolic process
1.51 1.92e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
3.20 1.94e-02 GO:0032886 regulation of microtubule-based process
1.14 2.03e-02 GO:0008152 metabolic process
1.95 2.14e-02 GO:0048568 embryonic organ development
3.62 2.25e-02 GO:0031333 negative regulation of protein complex assembly
2.31 2.45e-02 GO:0048705 skeletal system morphogenesis
2.77 2.65e-02 GO:0050679 positive regulation of epithelial cell proliferation
3.01 2.91e-02 GO:0051147 regulation of muscle cell differentiation
1.74 3.17e-02 GO:0060341 regulation of cellular localization
2.28 3.22e-02 GO:0001763 morphogenesis of a branching structure
2.28 3.22e-02 GO:0008544 epidermis development
1.08 3.25e-02 GO:0009987 cellular process
5.48 3.31e-02 GO:0060420 regulation of heart growth
1.64 3.34e-02 GO:0009605 response to external stimulus
3.06 3.86e-02 GO:0045667 regulation of osteoblast differentiation
2.42 3.89e-02 GO:0030111 regulation of Wnt receptor signaling pathway
3.47 3.92e-02 GO:0043244 regulation of protein complex disassembly
1.68 4.26e-02 GO:0060548 negative regulation of cell death
2.24 4.78e-02 GO:0048545 response to steroid hormone stimulus
2.15 4.84e-02 GO:0043010 camera-type eye development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.27 3.23e-32 GO:0005622 intracellular
1.27 1.43e-30 GO:0044424 intracellular part
1.33 5.49e-26 GO:0005737 cytoplasm
1.27 1.63e-22 GO:0043226 organelle
1.27 2.47e-22 GO:0043229 intracellular organelle
1.13 4.79e-18 GO:0005623 cell
1.13 4.79e-18 GO:0044464 cell part
1.96 6.78e-18 GO:0000267 cell fraction
1.92 3.39e-15 GO:0042995 cell projection
2.01 5.45e-15 GO:0005626 insoluble fraction
1.24 6.11e-14 GO:0043231 intracellular membrane-bounded organelle
1.24 7.31e-14 GO:0043227 membrane-bounded organelle
2.27 9.03e-14 GO:0043005 neuron projection
1.42 1.34e-13 GO:0071944 cell periphery
1.74 2.21e-13 GO:0005856 cytoskeleton
1.32 2.49e-13 GO:0044444 cytoplasmic part
2.16 7.59e-13 GO:0030054 cell junction
1.96 9.24e-13 GO:0005624 membrane fraction
1.40 3.83e-12 GO:0005886 plasma membrane
2.55 5.22e-11 GO:0043025 neuronal cell body
2.23 6.50e-11 GO:0045202 synapse
2.50 7.09e-11 GO:0044297 cell body
1.56 6.15e-10 GO:0044459 plasma membrane part
2.44 1.68e-09 GO:0031012 extracellular matrix
2.53 2.96e-09 GO:0005578 proteinaceous extracellular matrix
2.20 9.63e-09 GO:0044463 cell projection part
3.46 1.39e-08 GO:0044420 extracellular matrix part
2.43 5.01e-08 GO:0015629 actin cytoskeleton
2.49 5.34e-08 GO:0030424 axon
1.26 2.82e-07 GO:0005634 nucleus
1.69 3.34e-07 GO:0044421 extracellular region part
2.19 1.02e-06 GO:0044456 synapse part
3.58 2.09e-06 GO:0030427 site of polarized growth
1.38 2.45e-06 GO:0043228 non-membrane-bounded organelle
1.38 2.45e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.66 2.51e-06 GO:0044430 cytoskeletal part
3.57 4.39e-06 GO:0030426 growth cone
1.59 4.22e-05 GO:0005794 Golgi apparatus
2.46 1.02e-04 GO:0031252 cell leading edge
1.98 1.08e-04 GO:0005625 soluble fraction
1.24 1.22e-04 GO:0044422 organelle part
2.71 2.55e-04 GO:0043292 contractile fiber
2.63 3.16e-04 GO:0033267 axon part
2.17 4.26e-04 GO:0005911 cell-cell junction
2.74 4.76e-04 GO:0030016 myofibril
2.03 4.85e-04 GO:0030425 dendrite
1.23 5.43e-04 GO:0044446 intracellular organelle part
1.98 8.12e-04 GO:0048471 perinuclear region of cytoplasm
1.40 1.14e-03 GO:0005829 cytosol
1.59 1.47e-03 GO:0005615 extracellular space
1.28 1.60e-03 GO:0043234 protein complex
2.51 1.91e-03 GO:0005912 adherens junction
4.89 1.97e-03 GO:0005581 collagen
2.93 2.41e-03 GO:0014069 postsynaptic density
3.43 3.57e-03 GO:0030018 Z disc
2.64 3.57e-03 GO:0044449 contractile fiber part
1.97 3.57e-03 GO:0005874 microtubule
2.86 3.60e-03 GO:0030027 lamellipodium
2.38 3.97e-03 GO:0070161 anchoring junction
3.96 4.41e-03 GO:0030175 filopodium
1.99 4.47e-03 GO:0045177 apical part of cell
2.38 5.51e-03 GO:0019717 synaptosome
2.86 5.93e-03 GO:0005604 basement membrane
1.33 6.92e-03 GO:0005576 extracellular region
2.65 8.04e-03 GO:0016327 apicolateral plasma membrane
3.03 1.16e-02 GO:0031674 I band
3.45 1.22e-02 GO:0031256 leading edge membrane
2.64 1.32e-02 GO:0030017 sarcomere
1.59 1.56e-02 GO:0015630 microtubule cytoskeleton
2.58 1.85e-02 GO:0043296 apical junction complex
2.19 2.76e-02 GO:0005938 cell cortex
2.03 3.06e-02 GO:0016324 apical plasma membrane
2.45 4.13e-02 GO:0008021 synaptic vesicle
3.11 4.19e-02 GO:0030863 cortical cytoskeleton
3.27 4.30e-02 GO:0005913 cell-cell adherens junction
1.20 4.49e-02 GO:0032991 macromolecular complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.54 2.31e-40 GO:0005515 protein binding
1.26 1.58e-28 GO:0005488 binding
2.40 1.11e-14 GO:0008092 cytoskeletal protein binding
1.84 2.56e-09 GO:0019899 enzyme binding
2.47 6.25e-09 GO:0003779 actin binding
2.03 4.77e-08 GO:0019904 protein domain specific binding
4.54 1.93e-06 GO:0008013 beta-catenin binding
1.98 4.27e-05 GO:0005198 structural molecule activity
1.99 1.01e-04 GO:0032403 protein complex binding
2.08 1.23e-04 GO:0019900 kinase binding
1.64 1.92e-04 GO:0001071 nucleic acid binding transcription factor activity
1.64 1.92e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
2.17 2.33e-04 GO:0019901 protein kinase binding
1.56 5.77e-04 GO:0030528 transcription regulator activity
3.49 6.02e-04 GO:0005178 integrin binding
1.49 1.86e-03 GO:0005102 receptor binding
1.51 2.72e-03 GO:XXXXXXX unannotated
2.47 2.97e-03 GO:0005539 glycosaminoglycan binding
1.37 3.23e-03 GO:0046914 transition metal ion binding
2.36 3.74e-03 GO:0001871 pattern binding
2.36 3.74e-03 GO:0030247 polysaccharide binding
3.33 4.50e-03 GO:0004714 transmembrane receptor protein tyrosine kinase activity
3.20 4.50e-03 GO:0019902 phosphatase binding
1.86 5.59e-03 GO:0016563 transcription activator activity
3.01 6.76e-03 GO:0019199 transmembrane receptor protein kinase activity
1.39 7.11e-03 GO:0008270 zinc ion binding
4.39 1.09e-02 GO:0005201 extracellular matrix structural constituent
2.35 2.24e-02 GO:0004713 protein tyrosine kinase activity
3.08 2.43e-02 GO:0051015 actin filament binding
2.35 3.12e-02 GO:0005516 calmodulin binding
2.50 3.44e-02 GO:0008201 heparin binding
11.57 3.91e-02 GO:0008157 protein phosphatase 1 binding