• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: HIF1A.p2

Z-value: 1.740

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_-_125075222	23.840	NM_001037298	Fam38a	family with sequence similarity 38, member A
chr10_+_43198945	21.892	NM_199028	Bend3	BEN domain containing 3
chr11_-_115971327	19.821	NM_172570	Trim47	tripartite motif-containing 47
chr8_+_49195311	14.709	NM_178788 NM_001161515	Dctd	dCMP deaminase
chr2_-_13977688	14.572		Ptpla	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr9_-_58160063	14.566		Loxl1	lysyl oxidase-like 1
chr19_+_7049425	13.520	NM_008889	Ppp1r14b	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_54101157	13.468	NM_010699	Ldha	lactate dehydrogenase A
chr12_+_33505307	13.392		Nampt	nicotinamide phosphoribosyltransferase
chr19_+_7049639	12.923		Ppp1r14b	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_+_33505364	12.777		Nampt	nicotinamide phosphoribosyltransferase
chr9_+_107490100	12.304		Ifrd2	interferon-related developmental regulator 2
chr4_-_118966945	12.234	NM_011732	Ybx1	Y box protein 1
chr14_-_45938164	11.916		Ero1l	ERO1-like (S. cerevisiae)
chr17_+_35137995	11.835		Vars	valyl-tRNA synthetase
chr10_-_68815606	11.724	NM_007659	Cdk1	cyclin-dependent kinase 1
chr7_+_54101226	11.163		Ldha	lactate dehydrogenase A
chr1_-_55144637	11.081		Hspd1	heat shock protein 1 (chaperonin)
chr2_-_169956719	10.922	NM_001033299	Zfp217	zinc finger protein 217
chr11_+_3190334	10.635	NM_019574	Patz1	POZ (BTB) and AT hook containing zinc finger 1
chr1_-_55144687	10.571	NM_010477	Hspd1	heat shock protein 1 (chaperonin)
chr2_+_27741864	10.569	NM_015734	Col5a1	collagen, type V, alpha 1
chr1_+_55145132	10.523		Hspe1	heat shock protein 1 (chaperonin 10)
chr9_+_107489981	10.491	NM_025903	Ifrd2	interferon-related developmental regulator 2
chr2_-_179777080	10.373	NM_011969	Psma7	proteasome (prosome, macropain) subunit, alpha type 7
chr14_-_31832274	10.356	NM_153547	Gnl3	guanine nucleotide binding protein-like 3 (nucleolar)
chr1_-_75176703	10.223	NM_023732	Abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr8_-_72498125	10.035		Gatad2a	GATA zinc finger domain containing 2A
chr8_+_34842304	9.996	NM_001167921	Gtf2e2	general transcription factor II E, polypeptide 2 (beta subunit)
chr2_-_13977502	9.609		Ptpla	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr11_-_102680467	9.568	NM_001159382	Gjc1	gap junction protein, gamma 1
chr16_+_32608981	9.448	NM_011638	Tfrc	transferrin receptor
chr10_-_119913990	9.374	NM_010441	Hmga2	high mobility group AT-hook 2
chr4_-_131901576	9.318	NM_001197082 NM_133878	Rcc1	regulator of chromosome condensation 1
chr16_-_22163264	9.156	NM_183029	Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2
chr14_-_45938187	8.998	NM_015774	Ero1l	ERO1-like (S. cerevisiae)
chr3_+_121948541	8.955		Gclm	glutamate-cysteine ligase, modifier subunit
chr1_-_75176965	8.945		Abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr7_-_59117613	8.838	NM_001115087	Fancf	Fanconi anemia, complementation group F
chr14_-_31832165	8.828		Gnl3	guanine nucleotide binding protein-like 3 (nucleolar)
chr17_-_35137799	8.748		D17H6S56E-5	DNA segment, Chr 17, human D6S56E 5
chr17_-_26232411	8.706	NM_019731	Nme4	non-metastatic cells 4, protein expressed in
chr1_-_33814537	8.567		Bag2	BCL2-associated athanogene 2
chr12_+_17551678	8.538	NM_013614	Odc1	ornithine decarboxylase, structural 1
chr14_-_45938236	8.511		Ero1l	ERO1-like (S. cerevisiae)
chr5_+_129526383	8.483		Ran	RAN, member RAS oncogene family
chr10_-_83996516	8.455		Ckap4	cytoskeleton-associated protein 4
chr2_-_73052484	8.340	NM_025942 NM_030091	Ola1	Obg-like ATPase 1
chr19_+_47654060	8.325		Slk	STE20-like kinase (yeast)
chr10_+_17443024	8.221	NM_010828	Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr4_-_118966829	8.015		Ybx1	Y box protein 1
chr4_+_107040634	7.923		Tmem48	transmembrane protein 48
chr9_-_43047862	7.830	NM_178644	Oaf	OAF homolog (Drosophila)
chr2_-_13977563	7.830	NM_001012396 NM_013935	Ptpla	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr7_-_112884943	7.729		Rrp8	ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr18_-_52689504	7.702		Lox	lysyl oxidase
chr8_+_109417539	7.622	NM_011574	Cirh1a	cirrhosis, autosomal recessive 1A (human)
chr11_-_115971521	7.615		Trim47	tripartite motif-containing 47
chr17_+_46633703	7.606	NM_207161	BC048355	cDNA sequence BC048355
chr5_+_129526060	7.551		Ran	RAN, member RAS oncogene family
chr1_-_145549758	7.546	NM_145991	Cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr14_-_32643594	7.512	NM_001024604	Ankrd28	ankyrin repeat domain 28
chr18_+_35713033	7.500		Matr3	matrin 3
chr7_-_112885071	7.426		Rrp8	ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr19_+_36908807	7.425		Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr7_-_112884969	7.386	NM_025897	Rrp8	ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr9_-_58160769	7.381		Loxl1	lysyl oxidase-like 1
chr8_-_123112974	7.371	NM_178856	Gins2	GINS complex subunit 2 (Psf2 homolog)
chr17_-_23814415	7.214	NM_001161746 NM_013749	Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a
chr1_-_75176926	7.176		Abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr10_-_83996632	6.993	NM_175451	Ckap4	cytoskeleton-associated protein 4
chr11_+_68859125	6.910	NM_011496	Aurkb	aurora kinase B
chr2_+_162880370	6.890	NM_008652	Mybl2	myeloblastosis oncogene-like 2
chrX_-_165111764	6.794	NM_010832	Msl3	male-specific lethal 3 homolog (Drosophila)
chr2_+_22751003	6.782	NM_019501	Pdss1	prenyl (solanesyl) diphosphate synthase, subunit 1
chr9_+_92437056	6.745	NM_001142916 NM_011961	Plod2	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr5_-_23289370	6.732	NM_178403	Pus7	pseudouridylate synthase 7 homolog (S. cerevisiae)
chr15_+_9001154	6.729		1110020G09Rik	RIKEN cDNA 1110020G09 gene
chr4_+_154937946	6.717		Nadk	NAD kinase
chr8_+_34842810	6.707	NM_001167922	Gtf2e2	general transcription factor II E, polypeptide 2 (beta subunit)
chr8_-_123112925	6.704		Gins2	GINS complex subunit 2 (Psf2 homolog)
chr4_+_154937914	6.680	NM_001159637	Nadk	NAD kinase
chr12_+_33505175	6.661	NM_021524	Nampt	nicotinamide phosphoribosyltransferase
chr9_-_88417710	6.656		Snhg5	small nucleolar RNA host gene 5
chr5_-_145726643	6.648	NM_001038627 NM_029438	Smurf1	SMAD specific E3 ubiquitin protein ligase 1
chr5_+_129525943	6.637	NM_009391	Ran	RAN, member RAS oncogene family
chr17_-_23814399	6.633		Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a
chr6_-_6167034	6.583		Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr6_-_6167113	6.576	NM_001177572 NM_015829	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr16_+_44724394	6.573	NM_145972	BC027231	cDNA sequence BC027231
chr12_-_77470450	6.572	NM_001172104 NM_028356	Zbtb25	zinc finger and BTB domain containing 25
chr6_-_6167086	6.547		Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr1_-_155179844	6.487	NM_010683	Lamc1	laminin, gamma 1
chr18_-_52689185	6.462		Lox	lysyl oxidase
chr2_-_144096582	6.426		Snx5	sorting nexin 5
chr11_-_57981970	6.420		Gemin5	gem (nuclear organelle) associated protein 5
chr2_+_22751081	6.394		Pdss1	prenyl (solanesyl) diphosphate synthase, subunit 1
chr1_-_33814590	6.389	NM_145392	Bag2	BCL2-associated athanogene 2
chr4_+_11118500	6.370	NM_001037134	Ccne2	cyclin E2
chr6_+_108778985	6.355		Edem1	ER degradation enhancer, mannosidase alpha-like 1
chr2_-_144096164	6.334		Snx5	sorting nexin 5
chr11_-_84326869	6.305	NM_019816	Aatf	apoptosis antagonizing transcription factor
chr17_-_56766191	6.245	NM_028782	Lonp1	lon peptidase 1, mitochondrial
chr17_-_50329593	6.241	NM_181397	Rftn1	raftlin lipid raft linker 1
chr5_+_123526279	6.209	NM_001039723	Tmem120b	transmembrane protein 120B
chr11_+_97177029	6.208	NM_025927	Mrpl45	mitochondrial ribosomal protein L45
chr6_-_88848650	6.200	NM_008564	Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr5_-_111082387	6.200	NM_153570	Noc4l	nucleolar complex associated 4 homolog (S. cerevisiae)
chr1_-_145549903	6.189		Cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr14_+_70009282	6.148	NM_033325	Loxl2	lysyl oxidase-like 2
chrX_+_93291377	6.131	NM_010833	Msn	moesin
chr19_+_47654508	6.108	NM_001164639 NM_009289	Slk	STE20-like kinase (yeast)
chr13_-_99660903	6.107	NM_001048267	Tnpo1	transportin 1
chr8_+_67471046	6.055	NM_001163747 NM_028427	Tmem192	transmembrane protein 192
chr8_+_86521498	6.024	NM_001081415	Samd1	sterile alpha motif domain containing 1
chr5_+_64484146	6.009	NM_025700	Pgm1	phosphoglucomutase 1
chr4_+_122960059	5.976	NM_130881	Pabpc4	poly(A) binding protein, cytoplasmic 4
chr10_+_68675404	5.955	NM_001081347	Rhobtb1	Rho-related BTB domain containing 1
chr17_+_35035898	5.923	NM_145830	Ehmt2	euchromatic histone lysine N-methyltransferase 2
chr8_+_131209787	5.784		Itgb1	integrin beta 1 (fibronectin receptor beta)
chr5_+_34000745	5.774	NM_001040435	Tacc3	transforming, acidic coiled-coil containing protein 3
chr14_-_62058627	5.757	NM_008466	Kpna3	karyopherin (importin) alpha 3
chr15_-_99705812	5.738	NM_001113545	Lima1	LIM domain and actin binding 1
chr5_+_129526311	5.730		Ran	RAN, member RAS oncogene family
chr8_-_87956665	5.723	NM_025722	4921524J17Rik	RIKEN cDNA 4921524J17 gene
chr6_-_131243197	5.702	NM_025564	Magohb	mago-nashi homolog B (Drosophila)
chr13_+_109106530	5.656	NM_178683	Depdc1b	DEP domain containing 1B
chr8_+_120022149	5.595	NM_172285	Plcg2	phospholipase C, gamma 2
chr10_+_79317316	5.525	NM_001077363 NM_008956	Ptbp1	polypyrimidine tract binding protein 1
chr8_-_124431581	5.476	NM_011404	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr7_-_26035683	5.474	NM_010155	Erf	Ets2 repressor factor
chr8_+_131209680	5.470		Itgb1	integrin beta 1 (fibronectin receptor beta)
chr11_+_120810346	5.424	NM_001038653 NM_001038654	Slc16a3	solute carrier family 16 (monocarboxylic acid transporters), member 3
chr4_+_101092307	5.423	NM_009647	Ak4	adenylate kinase 4
chr9_-_107888185	5.419		6230427J02Rik	RIKEN cDNA 6230427J02 gene
chr1_+_16655263	5.402	NM_026392 NM_027415	Tmem70	transmembrane protein 70
chr1_-_95375363	5.397		Hdlbp	high density lipoprotein (HDL) binding protein
chr11_-_88725877	5.380	NM_001042541	Akap1	A kinase (PRKA) anchor protein 1
chr7_-_52241669	5.378	NM_019830	Prmt1	protein arginine N-methyltransferase 1
chr4_+_46502141	5.353	NM_053179	Nans	N-acetylneuraminic acid synthase (sialic acid synthase)
chr2_-_174264400	5.338	NM_022325	Ctsz	cathepsin Z
chr9_-_96264446	5.324		Atp1b3	ATPase, Na+/K+ transporting, beta 3 polypeptide
chr8_-_124431559	5.317		Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr11_+_117710532	5.306	NM_001012273 NM_009689	Birc5	baculoviral IAP repeat-containing 5
chr1_-_155396839	5.291	NM_028749	F630010C12Rik Npl	RIKEN cDNA F630010C12 gene N-acetylneuraminate pyruvate lyase
chr11_+_74462965	5.222	NM_001081158	1300001I01Rik	RIKEN cDNA 1300001I01 gene
chr2_+_27370649	5.209	NM_080848	Wdr5	WD repeat domain 5
chr7_+_28233013	5.194		Blvrb	biliverdin reductase B (flavin reductase (NADPH))
chr1_-_38186482	5.185	NM_019570	Rev1	REV1 homolog (S. cerevisiae)
chr11_-_102680999	5.164	NM_001159383	Gjc1	gap junction protein, gamma 1
chr9_+_50665024	5.134	NM_001034085 NM_028614	Ppp2r1b	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform
chr18_-_52689279	5.042	NM_010728	Lox	lysyl oxidase
chr10_-_81063566	5.025	NM_053254	Tle6	transducin-like enhancer of split 6, homolog of Drosophila E(spl)
chr4_+_149611305	5.015	NM_023119	Eno1	enolase 1, alpha non-neuron
chr15_+_61869529	4.946		Pvt1	plasmacytoma variant translocation 1
chr4_+_147965596	4.938	NM_009272	Srm	spermidine synthase
chr1_+_93698037	4.930	NM_007855	Twist2	twist homolog 2 (Drosophila)
chr18_+_46757333	4.927	NM_010120	Eif1a	eukaryotic translation initiation factor 1A
chr1_+_137662648	4.891	NM_013750	Phlda3	pleckstrin homology-like domain, family A, member 3
chr6_+_29222698	4.881		2310016C08Rik	RIKEN cDNA 2310016C08 gene
chr16_+_20141134	4.880	NM_001033237 NM_001145930 NM_001145931	Yeats2	YEATS domain containing 2
chr2_-_31939210	4.877	NM_175511	Fam78a	family with sequence similarity 78, member A
chr10_-_75322897	4.804		Mif	macrophage migration inhibitory factor
chr10_-_60610398	4.796	NM_009163	Sgpl1	sphingosine phosphate lyase 1
chr16_+_14361637	4.795	NM_008576	Abcc1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1
chr17_+_35137851	4.794	NM_011690	Vars	valyl-tRNA synthetase
chr12_-_40764514	4.794		Arl4a	ADP-ribosylation factor-like 4A
chr3_+_121948693	4.791		Gclm	glutamate-cysteine ligase, modifier subunit
chr3_-_8923789	4.772	NM_025434	Mrps28	mitochondrial ribosomal protein S28
chr6_-_52108249	4.769	NM_010449	Hoxa1	homeobox A1
chr5_-_111082269	4.768		Noc4l	nucleolar complex associated 4 homolog (S. cerevisiae)
chr10_+_121176978	4.752	NM_173022	BC048403	cDNA sequence BC048403
chr3_+_121948399	4.750	NM_008129	Gclm	glutamate-cysteine ligase, modifier subunit
chr3_-_142544883	4.720	NM_178654	Pkn2	protein kinase N2
chr7_+_105851755	4.719	NM_028410	Prkrir	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr12_+_52449216	4.713	NM_001015099 NM_001167963 NM_001167964	G2e3	G2/M-phase specific E3 ubiquitin ligase
chr8_+_131209614	4.699		Itgb1	integrin beta 1 (fibronectin receptor beta)
chr14_+_70008874	4.696		Loxl2	lysyl oxidase-like 2
chr11_+_100931369	4.693	NM_013792	Naglu	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr10_-_75322941	4.691	NM_010798	Mif	macrophage migration inhibitory factor
chr10_-_127648817	4.655	NM_025716	Spryd4	SPRY domain containing 4
chr12_+_77471506	4.648		Zbtb1	zinc finger and BTB domain containing 1
chr6_+_29222664	4.630		2310016C08Rik	RIKEN cDNA 2310016C08 gene
chr2_+_172847371	4.630	NM_019547	Rbm38	RNA binding motif protein 38
chrX_+_103382432	4.629	NM_008828	Pgk1	phosphoglycerate kinase 1
chr11_-_116713532	4.615		Srsf2	serine/arginine-rich splicing factor 2
chr12_-_32746061	4.604	NM_011158	Prkar2b	protein kinase, cAMP dependent regulatory, type II beta
chr4_-_41688124	4.602	NM_011014	Sigmar1	sigma non-opioid intracellular receptor 1
chr14_+_31832340	4.585		Pbrm1	polybromo 1
chr6_+_17015159	4.576		Tes	testis derived transcript
chr16_+_70314331	4.561	NM_028803	Gbe1	glucan (1,4-alpha-), branching enzyme 1
chr17_-_46168654	4.549		Vegfa	vascular endothelial growth factor A
chr18_+_67448839	4.541	NM_053261	Impa2	inositol (myo)-1(or 4)-monophosphatase 2
chr5_-_90652790	4.539		Cox18	COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr15_-_94373918	4.531	NM_172437	Pus7l	pseudouridylate synthase 7 homolog (S. cerevisiae)-like
chr6_+_29383152	4.512	NM_001081185	Flnc	filamin C, gamma
chr2_+_92024338	4.504	NM_138755	Phf21a	PHD finger protein 21A
chr12_+_17551771	4.493		Odc1	ornithine decarboxylase, structural 1
chr4_-_133801438	4.487	NM_024215	Zfp593	zinc finger protein 593
chr5_-_111209468	4.483	NM_001025561 NM_019700 NM_001025562	Pus1	pseudouridine synthase 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.56	6.94e-42	GO:0044237	cellular metabolic process
1.70	2.75e-41	GO:0044260	cellular macromolecule metabolic process
1.47	1.51e-37	GO:0008152	metabolic process
1.52	1.72e-36	GO:0044238	primary metabolic process
1.61	4.86e-36	GO:0043170	macromolecule metabolic process
1.84	4.10e-35	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.77	4.23e-35	GO:0006807	nitrogen compound metabolic process
1.78	1.78e-34	GO:0034641	cellular nitrogen compound metabolic process
1.91	4.24e-31	GO:0010467	gene expression
1.88	4.28e-31	GO:0090304	nucleic acid metabolic process
1.92	7.44e-29	GO:0016070	RNA metabolic process
1.81	2.85e-26	GO:0010468	regulation of gene expression
1.74	3.41e-26	GO:0044249	cellular biosynthetic process
1.72	1.62e-25	GO:0009058	biosynthetic process
1.68	5.00e-25	GO:0060255	regulation of macromolecule metabolic process
1.82	5.25e-25	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.79	4.54e-24	GO:0010556	regulation of macromolecule biosynthetic process
1.82	1.10e-23	GO:0009059	macromolecule biosynthetic process
1.82	1.26e-23	GO:0034645	cellular macromolecule biosynthetic process
1.64	2.24e-23	GO:0031323	regulation of cellular metabolic process
1.75	3.70e-23	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.82	3.88e-23	GO:0051252	regulation of RNA metabolic process
1.75	5.55e-23	GO:0051171	regulation of nitrogen compound metabolic process
1.75	5.80e-23	GO:0031326	regulation of cellular biosynthetic process
1.74	6.24e-23	GO:0009889	regulation of biosynthetic process
1.83	6.97e-23	GO:0006355	regulation of transcription, DNA-dependent
1.63	8.00e-23	GO:0080090	regulation of primary metabolic process
1.58	1.06e-22	GO:0019222	regulation of metabolic process
1.92	5.44e-20	GO:0032774	RNA biosynthetic process
1.91	9.65e-20	GO:0006351	transcription, DNA-dependent
1.71	6.33e-16	GO:0071841	cellular component organization or biogenesis at cellular level
1.56	4.21e-14	GO:0071840	cellular component organization or biogenesis
1.18	1.06e-13	GO:0009987	cellular process
1.66	9.88e-13	GO:0071842	cellular component organization at cellular level
1.82	2.87e-12	GO:0006996	organelle organization
2.00	6.51e-12	GO:0010605	negative regulation of macromolecule metabolic process
2.85	9.16e-12	GO:0016568	chromatin modification
1.99	1.22e-11	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.48	2.70e-11	GO:0032502	developmental process
1.52	2.79e-11	GO:0016043	cellular component organization
1.61	5.42e-11	GO:0048523	negative regulation of cellular process
2.63	9.63e-11	GO:0006325	chromatin organization
1.49	1.03e-10	GO:0007275	multicellular organismal development
1.90	1.54e-10	GO:0009892	negative regulation of metabolic process
1.56	2.77e-10	GO:0048519	negative regulation of biological process
1.57	4.23e-10	GO:0044267	cellular protein metabolic process
2.12	1.00e-09	GO:0010629	negative regulation of gene expression
2.32	1.48e-09	GO:0051276	chromosome organization
1.50	1.67e-09	GO:0048856	anatomical structure development
1.86	1.31e-08	GO:0031324	negative regulation of cellular metabolic process
2.00	3.61e-08	GO:0010558	negative regulation of macromolecule biosynthetic process
1.50	3.65e-08	GO:0048731	system development
2.68	3.91e-08	GO:0018193	peptidyl-amino acid modification
2.08	4.01e-08	GO:0006915	apoptosis
2.02	4.12e-08	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
2.02	4.69e-08	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.07	4.69e-08	GO:0012501	programmed cell death
2.21	4.73e-08	GO:0009792	embryo development ending in birth or egg hatching
2.22	5.82e-08	GO:0043009	chordate embryonic development
1.99	1.12e-07	GO:0051172	negative regulation of nitrogen compound metabolic process
1.90	1.76e-07	GO:0009790	embryo development
1.93	2.49e-07	GO:0031327	negative regulation of cellular biosynthetic process
1.96	3.56e-07	GO:0016265	death
1.91	4.44e-07	GO:0009890	negative regulation of biosynthetic process
2.02	4.75e-07	GO:0051253	negative regulation of RNA metabolic process
2.03	4.94e-07	GO:0045892	negative regulation of transcription, DNA-dependent
2.98	5.31e-07	GO:0016570	histone modification
1.56	5.44e-07	GO:0048513	organ development
1.43	6.61e-07	GO:0019538	protein metabolic process
2.93	8.90e-07	GO:0016569	covalent chromatin modification
1.56	9.51e-07	GO:0043412	macromolecule modification
1.94	9.81e-07	GO:0008219	cell death
2.08	1.26e-06	GO:0006396	RNA processing
1.84	2.07e-06	GO:0007049	cell cycle
2.41	4.58e-06	GO:0001701	in utero embryonic development
1.61	5.58e-06	GO:0009653	anatomical structure morphogenesis
3.63	7.12e-06	GO:0018205	peptidyl-lysine modification
1.54	8.15e-06	GO:0006464	protein modification process
2.73	2.01e-05	GO:0071843	cellular component biogenesis at cellular level
1.47	2.39e-05	GO:0030154	cell differentiation
2.73	4.81e-05	GO:0022613	ribonucleoprotein complex biogenesis
2.09	5.42e-05	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
1.45	5.96e-05	GO:0048869	cellular developmental process
1.71	1.09e-04	GO:0009888	tissue development
3.94	1.86e-04	GO:0016573	histone acetylation
1.92	2.00e-04	GO:0048646	anatomical structure formation involved in morphogenesis
1.92	2.49e-04	GO:0072358	cardiovascular system development
1.92	2.49e-04	GO:0072359	circulatory system development
3.70	2.82e-04	GO:0050657	nucleic acid transport
3.70	2.82e-04	GO:0050658	RNA transport
3.70	2.82e-04	GO:0051236	establishment of RNA localization
3.82	3.15e-04	GO:0006475	internal protein amino acid acetylation
3.82	3.15e-04	GO:0018393	internal peptidyl-lysine acetylation
2.15	3.37e-04	GO:0051301	cell division
3.77	4.06e-04	GO:0018394	peptidyl-lysine acetylation
1.62	4.06e-04	GO:0050793	regulation of developmental process
2.97	4.09e-04	GO:0042254	ribosome biogenesis
1.66	4.71e-04	GO:0051173	positive regulation of nitrogen compound metabolic process
1.64	5.00e-04	GO:0031328	positive regulation of cellular biosynthetic process
3.56	5.76e-04	GO:0006403	RNA localization
2.25	6.13e-04	GO:0001501	skeletal system development
1.62	7.50e-04	GO:0009891	positive regulation of biosynthetic process
1.96	1.03e-03	GO:0022403	cell cycle phase
3.28	1.41e-03	GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport
1.69	1.53e-03	GO:0045893	positive regulation of transcription, DNA-dependent
1.69	1.58e-03	GO:0051254	positive regulation of RNA metabolic process
1.64	1.59e-03	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.48	1.68e-03	GO:0006473	protein acetylation
1.35	1.73e-03	GO:0048522	positive regulation of cellular process
1.59	2.06e-03	GO:0044085	cellular component biogenesis
1.76	2.25e-03	GO:0009887	organ morphogenesis
1.79	2.51e-03	GO:0022402	cell cycle process
1.53	2.51e-03	GO:0007399	nervous system development
1.79	2.89e-03	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.52	3.31e-03	GO:0033036	macromolecule localization
1.98	3.60e-03	GO:0007389	pattern specification process
1.49	4.41e-03	GO:0031325	positive regulation of cellular metabolic process
3.54	4.63e-03	GO:0051028	mRNA transport
1.47	4.82e-03	GO:0009893	positive regulation of metabolic process
1.60	5.45e-03	GO:0010557	positive regulation of macromolecule biosynthetic process
1.62	5.63e-03	GO:0010628	positive regulation of gene expression
3.10	6.94e-03	GO:0043543	protein acylation
1.93	7.59e-03	GO:0000278	mitotic cell cycle
1.84	8.48e-03	GO:0051726	regulation of cell cycle
3.39	9.01e-03	GO:0006479	protein methylation
3.39	9.01e-03	GO:0008213	protein alkylation
2.62	9.16e-03	GO:0006913	nucleocytoplasmic transport
1.47	1.13e-02	GO:0010604	positive regulation of macromolecule metabolic process
1.41	1.28e-02	GO:0044281	small molecule metabolic process
2.56	1.39e-02	GO:0051169	nuclear transport
1.95	1.40e-02	GO:0016071	mRNA metabolic process
1.58	2.07e-02	GO:0048468	cell development
1.29	2.11e-02	GO:0048518	positive regulation of biological process
2.04	2.24e-02	GO:0006397	mRNA processing
2.45	2.26e-02	GO:0048705	skeletal system morphogenesis
2.33	2.36e-02	GO:0034470	ncRNA processing
2.05	2.53e-02	GO:0007507	heart development
2.15	2.80e-02	GO:0034660	ncRNA metabolic process
1.95	2.90e-02	GO:0035295	tube development
2.10	3.00e-02	GO:0010608	posttranscriptional regulation of gene expression
1.92	3.24e-02	GO:0000279	M phase
2.04	3.43e-02	GO:0008380	RNA splicing
2.10	3.71e-02	GO:0048514	blood vessel morphogenesis
1.54	4.56e-02	GO:2000026	regulation of multicellular organismal development
1.93	4.59e-02	GO:0001944	vasculature development

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.44	1.83e-73	GO:0005622	intracellular
1.45	3.07e-73	GO:0044424	intracellular part
1.57	1.05e-69	GO:0043231	intracellular membrane-bounded organelle
1.57	1.31e-69	GO:0043227	membrane-bounded organelle
1.50	4.66e-67	GO:0043226	organelle
1.51	5.42e-67	GO:0043229	intracellular organelle
1.77	1.90e-55	GO:0005634	nucleus
2.10	2.62e-30	GO:0044428	nuclear part
1.37	1.29e-27	GO:0005737	cytoplasm
1.17	1.54e-26	GO:0005623	cell
1.17	1.54e-26	GO:0044464	cell part
2.01	1.67e-24	GO:0031974	membrane-enclosed lumen
2.02	2.16e-24	GO:0070013	intracellular organelle lumen
2.01	2.84e-24	GO:0043233	organelle lumen
2.09	1.17e-23	GO:0031981	nuclear lumen
1.55	3.34e-22	GO:0044446	intracellular organelle part
1.53	3.23e-21	GO:0044422	organelle part
1.36	2.14e-14	GO:0044444	cytoplasmic part
2.02	5.69e-14	GO:0005654	nucleoplasm
1.73	2.86e-11	GO:0005739	mitochondrion
2.11	2.17e-10	GO:0044451	nucleoplasm part
1.49	8.58e-09	GO:0043228	non-membrane-bounded organelle
1.49	8.58e-09	GO:0043232	intracellular non-membrane-bounded organelle
1.39	2.63e-08	GO:0032991	macromolecular complex
2.37	2.91e-08	GO:0005730	nucleolus
1.55	3.82e-06	GO:0005829	cytosol
1.35	5.08e-05	GO:0043234	protein complex
7.15	9.17e-05	GO:0031519	PcG protein complex
1.91	1.36e-04	GO:0030529	ribonucleoprotein complex
1.77	1.77e-04	GO:0031967	organelle envelope
2.48	2.83e-04	GO:0005635	nuclear envelope
1.75	3.21e-04	GO:0031975	envelope
7.19	3.55e-04	GO:0032592	integral to mitochondrial membrane
1.89	1.04e-03	GO:0044427	chromosomal part
1.84	1.44e-03	GO:0005694	chromosome
2.41	2.32e-03	GO:0005840	ribosome
3.39	4.61e-03	GO:0000123	histone acetyltransferase complex
2.13	1.15e-02	GO:0000785	chromatin
3.23	1.60e-02	GO:0000792	heterochromatin
2.10	2.09e-02	GO:0000228	nuclear chromosome
3.70	2.26e-02	GO:0005643	nuclear pore
2.52	2.82e-02	GO:0005819	spindle
2.85	2.83e-02	GO:0016585	chromatin remodeling complex
5.17	2.92e-02	GO:0001739	sex chromatin
2.66	2.95e-02	GO:0000790	nuclear chromatin
2.43	3.49e-02	GO:0031301	integral to organelle membrane
4.94	4.30e-02	GO:0000803	sex chromosome
1.43	4.35e-02	GO:0005783	endoplasmic reticulum

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.90	7.02e-32	GO:0003676	nucleic acid binding
1.25	5.51e-23	GO:0005488	binding
1.82	4.86e-17	GO:0003677	DNA binding
2.15	8.53e-12	GO:0003723	RNA binding
1.29	2.70e-09	GO:0005515	protein binding
1.84	3.01e-08	GO:0030528	transcription regulator activity
1.50	5.94e-08	GO:0000166	nucleotide binding
1.65	1.23e-07	GO:0008270	zinc ion binding
1.28	1.43e-07	GO:0003824	catalytic activity
2.43	2.94e-07	GO:0016564	transcription repressor activity
1.54	6.87e-07	GO:0016740	transferase activity
1.55	1.10e-06	GO:0046914	transition metal ion binding
1.84	1.54e-06	GO:0001071	nucleic acid binding transcription factor activity
1.84	1.54e-06	GO:0003700	sequence-specific DNA binding transcription factor activity
1.89	3.25e-06	GO:0043565	sequence-specific DNA binding
1.47	4.10e-05	GO:0035639	purine ribonucleoside triphosphate binding
1.46	4.25e-05	GO:0032553	ribonucleotide binding
1.45	6.54e-05	GO:0032555	purine ribonucleotide binding
1.45	8.70e-05	GO:0017076	purine nucleotide binding
1.50	1.39e-04	GO:0005524	ATP binding
1.49	1.56e-04	GO:0032559	adenyl ribonucleotide binding
1.48	2.12e-04	GO:0030554	adenyl nucleotide binding
1.58	1.21e-03	GO:0016772	transferase activity, transferring phosphorus-containing groups
1.27	2.04e-03	GO:0046872	metal ion binding
1.27	2.09e-03	GO:0043169	cation binding
2.02	2.43e-03	GO:0008134	transcription factor binding
1.26	2.86e-03	GO:0043167	ion binding
2.27	3.42e-03	GO:0003682	chromatin binding
1.82	1.09e-02	GO:0016874	ligase activity
3.59	1.30e-02	GO:0008276	protein methyltransferase activity
2.80	1.40e-02	GO:0016566	specific transcriptional repressor activity
4.27	1.70e-02	GO:0019205	nucleobase, nucleoside, nucleotide kinase activity
1.54	1.95e-02	GO:0016301	kinase activity
2.26	4.57e-02	GO:0008168	methyltransferase activity