Motif ID: HNF1A.p2

Z-value: 4.743


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
Hnf1a 21405 HNF1 homeobox A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hnf1achr5_-_115421045-0.101.9e-01Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_89886732 159.826 NM_008096
Gc
group specific component
chr7_+_147949708 153.649 NM_021282
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr5_-_87335956 110.056 NM_153598
Ugt2b34
UDP glucuronosyltransferase 2 family, polypeptide B34
chr11_-_11798138 110.044 NM_001190448
Ddc
dopa decarboxylase
chr2_+_163372889 104.931 NM_008261
Hnf4a
hepatic nuclear factor 4, alpha
chr18_-_43896767 103.190 NM_009258
Spink3
serine peptidase inhibitor, Kazal type 3
chr11_-_11798101 100.715 Ddc
dopa decarboxylase
chr5_+_90947970 96.088 NM_145146
Afm
afamin
chr1_+_90003410 95.963 Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr3_+_82830071 94.918 NM_001111048
NM_010196
Fga

fibrinogen alpha chain

chr5_+_90889937 93.716 Alb
albumin
chr12_-_104976382 93.679 NM_009244
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr5_+_90889913 93.511 NM_009654
Alb
albumin
chr12_-_104976324 93.092 Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr11_-_11798035 89.767 Ddc
dopa decarboxylase
chr7_+_147949637 89.320 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr12_-_105195097 87.761 NM_009247
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr5_-_87998014 86.725 NM_016771
Sult1d1
sulfotransferase family 1D, member 1
chr1_+_90034940 85.804 Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr12_-_105101768 85.520 Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr12_-_105101825 84.883 NM_009243
Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr12_-_105066203 84.841 Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr12_-_105101743 83.689 Serpina1a
Serpina1b
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1A
serine (or cysteine) preptidase inhibitor, clade A, member 1B
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr11_+_101229029 83.207 NM_008061
G6pc
glucose-6-phosphatase, catalytic
chr12_-_105143089 82.043 Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr5_-_87997908 79.393 Sult1d1
sulfotransferase family 1D, member 1
chr12_-_105143108 78.084 NM_009245
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr2_+_162813260 77.437 Sgk2
serum/glucocorticoid regulated kinase 2
chr10_+_60552061 77.145 NM_025273
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr13_+_4232981 75.345 NM_001013785
Akr1c19
aldo-keto reductase family 1, member C19
chr3_+_129539656 74.641 NM_007686
Cfi
complement component factor i
chr1_+_90108533 74.401 NM_201645
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr3_-_82853711 73.956 NM_181849
Fgb
fibrinogen beta chain
chr13_+_4190423 71.959 NM_013778
Akr1c13
aldo-keto reductase family 1, member C13
chr2_+_163372996 71.713 Hnf4a
hepatic nuclear factor 4, alpha
chr5_+_35384200 70.836 NM_019447
Hgfac
hepatocyte growth factor activator
chr1_+_89967340 70.524 NM_201644
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr13_-_4278605 69.856 NM_013777
Akr1c12
aldo-keto reductase family 1, member C12
chr5_+_35384213 69.856 Hgfac
hepatocyte growth factor activator
chr12_-_105011795 68.510 Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr12_-_105011807 68.303 NM_009246
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr12_-_105011767 68.066 Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr5_-_87569342 65.626 NM_009467
Ugt2b5
UDP glucuronosyltransferase 2 family, polypeptide B5
chr2_+_162813216 65.063 NM_013731
Sgk2
serum/glucocorticoid regulated kinase 2
chr2_-_91476551 64.067 NM_010168
F2
coagulation factor II
chr3_+_59835700 61.872 NM_023383
Aadac
arylacetamide deacetylase (esterase)
chr17_-_35268696 61.532 NM_018816
Apom
apolipoprotein M
chr1_+_141398282 60.713 NM_031164
F13b
coagulation factor XIII, beta subunit
chr4_+_115273542 60.464 NM_001100181
Cyp4a32
cytochrome P450, family 4, subfamily a, polypeptide 32
chr1_+_90097175 59.305 NM_013701
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
chrX_+_98572571 58.072 NM_008124
Gjb1
gap junction protein, beta 1
chr11_+_7097781 57.656 NM_008341
Igfbp1
insulin-like growth factor binding protein 1
chr1_-_132558108 56.670 NM_007576
C4bp
complement component 4 binding protein
chr2_-_34916915 55.564 NM_010406
Hc
hemolytic complement
chr17_+_12571455 54.628 NM_008877
Plg
plasminogen
chr14_+_51715674 54.264 NM_007447
NM_201239
Ang
Rnase4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family 4
chr13_+_54802831 53.363 Cdhr2
cadherin-related family member 2
chr9_-_76893529 53.087 NM_012033
Tinag
tubulointerstitial nephritis antigen
chr17_+_12571494 52.813 Plg
plasminogen
chr13_+_54802823 52.157 NM_001033364
Cdhr2
cadherin-related family member 2
chr4_+_138523061 51.524 Rnf186
ring finger protein 186
chr13_+_4433567 50.058 NM_030611
Akr1c6
aldo-keto reductase family 1, member C6
chr2_+_163332550 49.747 Hnf4a
hepatic nuclear factor 4, alpha
chr14_-_49865069 49.593 NM_025956
1700011H14Rik
RIKEN cDNA 1700011H14 gene
chr5_-_87521574 49.505 NM_001029867
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr10_+_62524324 48.908 NM_026701
Pbld1
phenazine biosynthesis-like protein domain containing 1
chr4_+_138523026 48.363 NM_025786
Rnf186
ring finger protein 186
chr4_-_96330818 48.077 Cyp2j5
cytochrome P450, family 2, subfamily j, polypeptide 5
chr8_+_107572489 47.848 NM_001164681
NM_198672
Ces3a

carboxylesterase 3A

chr15_+_9209583 47.539 NM_207216
Ugt3a1
UDP glycosyltransferases 3 family, polypeptide A1
chr11_-_75252976 47.321 NM_008878
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr8_+_107607652 46.503 NM_001159415
NM_144511
Ces3b

carboxylesterase 3B

chr18_+_20823908 45.544 Ttr
transthyretin
chr12_-_104869612 45.105 NM_144834
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr6_+_141578016 42.923 NM_020495
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr19_-_39815590 42.495 NM_001039555
Cyp2c68
cytochrome P450, family 2, subfamily c, polypeptide 68
chr7_-_31900188 42.117 NM_001110252
NM_008281
Hpn

hepsin

chr6_+_71149869 41.800 NM_017399
Fabp1
fatty acid binding protein 1, liver
chr3_-_98697132 41.228 NM_019545
Hao2
hydroxyacid oxidase 2
chr19_+_42120340 41.134 NM_026152
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chrX_+_160528118 40.380 NM_020626
Tmem27
transmembrane protein 27
chr14_+_51716032 39.629 Ang
Rnase4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family 4
chr5_-_87766219 38.800 NM_028094
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_-_96330805 38.079 NM_010007
Cyp2j5
cytochrome P450, family 2, subfamily j, polypeptide 5
chr19_+_43856793 37.942 NM_013806
Abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr7_+_31278689 36.967 Prodh2
proline dehydrogenase (oxidase) 2
chr5_+_33447075 36.925 Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr7_-_126622690 36.664 NM_009470
Umod
uromodulin
chr4_+_119310319 36.456 NM_008190
Guca2a
guanylate cyclase activator 2a (guanylin)
chr5_-_87355527 36.440 NM_152811
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
chr7_-_86987169 35.958 NM_008486
Anpep
alanyl (membrane) aminopeptidase
chr4_+_150227911 35.737 Errfi1
ERBB receptor feedback inhibitor 1
chr5_-_87766195 35.231 Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr5_-_87521097 34.826 Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr1_+_135206360 34.357 NM_026680
Golt1a
golgi transport 1 homolog A (S. cerevisiae)
chr19_-_39815529 34.286 Cyp2c68
cytochrome P450, family 2, subfamily c, polypeptide 68
chr2_-_62249889 34.068 Dpp4
dipeptidylpeptidase 4
chr9_+_44206431 34.001 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr5_-_109104347 33.977 Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr5_-_109104366 33.590 Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr19_+_56362397 33.546 NM_146101
Habp2
hyaluronic acid binding protein 2
chr8_-_109589522 33.123 NM_025458
Tmed6
transmembrane emp24 protein transport domain containing 6
chr11_+_108256590 32.875 NM_013475
Apoh
apolipoprotein H
chr5_-_109104394 32.776 Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr4_+_45861687 31.506 NM_028788
1300002K09Rik
RIKEN cDNA 1300002K09 gene
chr7_+_127317371 31.288 NM_028085
Anks4b
ankyrin repeat and sterile alpha motif domain containing 4B
chr3_+_57229331 30.882 NM_145539
Tm4sf4
transmembrane 4 superfamily member 4
chr1_+_174628164 30.651 NM_007768
Crp
C-reactive protein, pentraxin-related
chr19_+_30307417 30.579 Mbl2
mannose-binding lectin (protein C) 2
chr4_-_96330738 30.384 Cyp2j5
cytochrome P450, family 2, subfamily j, polypeptide 5
chr15_-_82624668 29.393 NM_029562
Cyp2d26
cytochrome P450, family 2, subfamily d, polypeptide 26
chr1_+_90062550 29.213 NM_201643
Ugt1a5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr9_-_106060406 28.946 NM_001039586
NM_174846
Glyctk

glycerate kinase

chr6_-_85781824 28.407 NM_023455
Nat8
N-acetyltransferase 8 (GCN5-related, putative)
chr3_-_98367865 28.117 NM_001111336
NM_008294
Hsd3b4

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4

chr13_-_56649898 28.063 NM_010702
Lect2
leukocyte cell-derived chemotaxin 2
chr13_-_56649852 27.809 Lect2
leukocyte cell-derived chemotaxin 2
chr1_-_174825081 27.755 Apcs
serum amyloid P-component
chr3_-_98314394 27.725 NM_001111336
NM_008294
Hsd3b4

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4

chr9_-_70782366 27.545 Lipc
lipase, hepatic
chr9_-_71011053 27.178 NM_022026
Aqp9
aquaporin 9
chr4_+_11685294 26.801 NM_019753
Cdh17
cadherin 17
chr5_+_87429884 26.767 NM_172881
Ugt2b35
UDP glucuronosyltransferase 2 family, polypeptide B35
chr7_+_31278675 26.764 NM_019546
Prodh2
proline dehydrogenase (oxidase) 2
chr1_-_174825160 26.688 NM_011318
Apcs
serum amyloid P-component
chr1_+_90062617 26.385 Ugt1a5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr18_+_20823750 25.922 NM_013697
Ttr
transthyretin
chr6_-_141895265 25.736 Slco1a1
solute carrier organic anion transporter family, member 1a1
chr19_+_30307446 25.172 NM_010776
Mbl2
mannose-binding lectin (protein C) 2
chr10_+_76038388 25.137 NM_080845
Ftcd
formiminotransferase cyclodeaminase
chr15_-_82624638 25.102 Cyp2d26
cytochrome P450, family 2, subfamily d, polypeptide 26
chr14_+_41964744 24.999 NM_010775
Mbl1
mannose-binding lectin (protein A) 1
chr12_-_104895293 24.800 Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr19_+_24748487 24.702 NM_183160
E030010A14Rik
RIKEN cDNA E030010A14 gene
chr16_+_96583361 24.579 NM_001177887
NM_001177886
NM_028078
Igsf5


immunoglobulin superfamily, member 5


chr16_+_22951144 24.424 NM_053176
Hrg
histidine-rich glycoprotein
chr1_-_164816645 23.987 Fmo2
flavin containing monooxygenase 2
chr9_-_70782614 23.809 NM_008280
Lipc
lipase, hepatic
chr12_+_105316152 23.455 Serpina4-ps1
serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1
chr11_+_115773633 23.298 1110017F19Rik
RIKEN cDNA 1110017F19 gene
chr4_+_19745871 23.113 NM_028746
Slc7a13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr16_+_22951183 22.762 Hrg
histidine-rich glycoprotein
chr6_-_141895336 22.540 NM_013797
Slco1a1
solute carrier organic anion transporter family, member 1a1
chr2_-_134380065 22.464 NM_010403
Hao1
hydroxyacid oxidase 1, liver
chr3_+_57229362 21.910 Tm4sf4
transmembrane 4 superfamily member 4
chr2_+_110437454 21.865 NM_001003915
NM_001177624
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr15_-_58220798 21.705 NM_027211
Anxa13
annexin A13
chr19_+_31943250 21.698 NM_001081074
A1cf
APOBEC1 complementation factor
chr6_+_29809595 21.637 NM_001171001
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr12_-_104895280 21.588 NM_007618
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr12_-_104895307 21.370 Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr4_+_11685359 21.181 Cdh17
cadherin 17
chr1_+_135142673 20.981 NM_001160268
NM_182930
Plekha6

pleckstrin homology domain containing, family A member 6

chr11_+_115773273 20.971 NM_001162998
1110017F19Rik
RIKEN cDNA 1110017F19 gene
chr10_-_124765435 20.921 NM_011391
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr8_-_107148093 20.756 NM_007663
Cdh16
cadherin 16
chr10_-_127837521 20.501 NM_028051
NM_028092
Slc39a5

solute carrier family 39 (metal ion transporter), member 5

chr5_-_87683812 20.261 NM_053215
Ugt2b37
UDP glucuronosyltransferase 2 family, polypeptide B37
chr13_+_23898861 19.528 NM_144836
Slc17a2
solute carrier family 17 (sodium phosphate), member 2
chr6_-_85770936 19.418 NM_023493
Cml5
Cml3
camello-like 5
camello-like 3
chr13_-_56649769 18.746 Lect2
leukocyte cell-derived chemotaxin 2
chr6_-_24118065 18.612 NM_019481
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr2_-_164047343 18.606 NM_001045554
NM_138685
Wfdc15b

WAP four-disulfide core domain 15B

chr4_-_149377238 18.547 H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr1_+_176260648 17.973 NM_025470
1810030J14Rik
RIKEN cDNA 1810030J14 gene
chr5_-_109104587 17.718 NM_174870
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr1_-_20608010 17.640 NM_153179
Pkhd1
polycystic kidney and hepatic disease 1
chr19_-_39723518 17.182 NM_001024719
Cyp2c67
cytochrome P450, family 2, subfamily c, polypeptide 67
chr10_+_23614493 16.503 NM_011704
Vnn1
vanin 1
chr6_+_129462572 16.422 NM_001081186
D630042F21Rik
RIKEN cDNA D630042F21 gene
chr12_+_32123083 16.096 NM_021353
Slc26a3
solute carrier family 26, member 3
chr9_+_45214037 15.709 NM_007503
Fxyd2
FXYD domain-containing ion transport regulator 2
chr2_-_6110280 15.504 Echdc3
enoyl Coenzyme A hydratase domain containing 3
chr7_+_36234110 15.390 NM_001199015
NM_001199016
NM_021291
Slc7a9


solute carrier family 7 (cationic amino acid transporter, y+ system), member 9


chr1_-_138856866 15.325 NM_030676
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr13_-_4522566 15.268 NM_054080
Akr1c20
aldo-keto reductase family 1, member C20
chr2_-_62249934 14.826 NM_001159543
NM_010074
Dpp4

dipeptidylpeptidase 4

chr1_-_174825067 14.299 Apcs
serum amyloid P-component
chr13_-_73815446 14.260 NM_001040692
NM_001136087
NM_001168643
NM_001168644
NM_001168645
NM_001168646
Slc6a18





solute carrier family 6 (neurotransmitter transporter), member 18





chr2_+_172978566 14.220 NM_011044
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chrX_-_159402465 13.883 S100g
S100 calcium binding protein G
chr13_+_55254169 12.891 NM_008011
Fgfr4
fibroblast growth factor receptor 4
chr13_+_23931302 12.794 NM_001164743
NM_134069
Slc17a3

solute carrier family 17 (sodium phosphate), member 3

chr8_-_5105158 12.580 NM_011388
Slc10a2
solute carrier family 10, member 2
chr5_-_91069499 12.250 NM_028478
Rassf6
Ras association (RalGDS/AF-6) domain family member 6
chr16_-_38433223 11.851 NM_134102
Pla1a
phospholipase A1 member A
chr10_+_34203204 11.739 NM_001159544
NM_010237
Frk

fyn-related kinase

chr12_+_60196786 10.957 NM_177321
Mia2
melanoma inhibitory activity 2
chr18_-_32297813 10.745 NM_001042768
NM_008934
Proc

protein C

chr3_-_69663781 10.521 NM_001164210
NM_133675
1110032A04Rik

RIKEN cDNA 1110032A04 gene

chr7_-_109019196 10.477 NM_008034
Folr1
folate receptor 1 (adult)
chr11_+_110829346 10.055 NM_010604
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr3_+_3508029 9.963 NM_013920
Hnf4g
hepatocyte nuclear factor 4, gamma
chr16_-_26755585 9.889


chr7_-_109019233 9.705 Folr1
folate receptor 1 (adult)
chr2_+_124978315 9.521 NM_001079690
NM_183354
Slc12a1

solute carrier family 12, member 1

chr15_-_102019373 9.426 Csad
cysteine sulfinic acid decarboxylase
chr6_-_3444484 9.152 NM_178899
Hepacam2
HEPACAM family member 2
chr5_-_36071673 8.923 Sh3tc1
SH3 domain and tetratricopeptide repeats 1
chr17_+_71553920 8.808 NM_001164885
Lpin2
lipin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
34.16 1.22e-10 GO:0006805 xenobiotic metabolic process
34.16 1.22e-10 GO:0071466 cellular response to xenobiotic stimulus
30.96 3.82e-10 GO:0009410 response to xenobiotic stimulus
5.62 4.28e-07 GO:0071702 organic substance transport
3.83 3.84e-06 GO:0055085 transmembrane transport
3.76 4.43e-05 GO:0006082 organic acid metabolic process
11.29 8.36e-05 GO:0010951 negative regulation of endopeptidase activity
17.34 1.12e-04 GO:0061041 regulation of wound healing
12.78 1.64e-04 GO:0015711 organic anion transport
56.60 2.88e-04 GO:0051918 negative regulation of fibrinolysis
7.08 3.94e-04 GO:0006725 cellular aromatic compound metabolic process
7.08 3.94e-04 GO:0006820 anion transport
18.58 5.93e-04 GO:0030193 regulation of blood coagulation
6.73 6.53e-04 GO:0015849 organic acid transport
10.30 8.97e-04 GO:0006639 acylglycerol metabolic process
10.03 1.09e-03 GO:0006638 neutral lipid metabolic process
16.07 1.46e-03 GO:0072376 protein activation cascade
39.62 1.69e-03 GO:0051917 regulation of fibrinolysis
15.24 2.01e-03 GO:0050818 regulation of coagulation
3.35 2.09e-03 GO:0019752 carboxylic acid metabolic process
3.35 2.09e-03 GO:0043436 oxoacid metabolic process
21.54 2.41e-03 GO:0006958 complement activation, classical pathway
7.50 2.78e-03 GO:0010466 negative regulation of peptidase activity
6.48 2.96e-03 GO:0042060 wound healing
3.26 3.12e-03 GO:0042180 cellular ketone metabolic process
74.29 3.38e-03 GO:0018879 biphenyl metabolic process
8.52 3.78e-03 GO:0006662 glycerol ether metabolic process
10.35 4.15e-03 GO:0006641 triglyceride metabolic process
2.98 4.25e-03 GO:0055114 oxidation-reduction process
6.20 4.41e-03 GO:0030162 regulation of proteolysis
6.20 4.41e-03 GO:0046942 carboxylic acid transport
8.35 4.44e-03 GO:0018904 organic ether metabolic process
18.35 5.60e-03 GO:0002455 humoral immune response mediated by circulating immunoglobulin
30.48 5.61e-03 GO:0030194 positive regulation of blood coagulation
3.23 6.15e-03 GO:0048878 chemical homeostasis
2.17 6.44e-03 GO:0042221 response to chemical stimulus
5.83 7.55e-03 GO:0071705 nitrogen compound transport
16.51 9.64e-03 GO:0006956 complement activation
2.12 1.01e-02 GO:0065008 regulation of biological quality
4.24 1.13e-02 GO:0034220 ion transmembrane transport
3.90 1.34e-02 GO:0009725 response to hormone stimulus
24.77 1.39e-02 GO:0030195 negative regulation of blood coagulation
24.77 1.39e-02 GO:0050820 positive regulation of coagulation
8.56 1.47e-02 GO:0007596 blood coagulation
8.56 1.47e-02 GO:0050817 coagulation
8.46 1.60e-02 GO:0007599 hemostasis
49.53 1.66e-02 GO:0009812 flavonoid metabolic process
49.53 1.66e-02 GO:0051818 disruption of cells of other organism involved in symbiotic interaction
49.53 1.66e-02 GO:0051883 killing of cells in other organism involved in symbiotic interaction
1.84 1.84e-02 GO:0051234 establishment of localization
5.22 1.99e-02 GO:0008202 steroid metabolic process
2.14 2.17e-02 GO:0044281 small molecule metabolic process
3.67 2.60e-02 GO:0009611 response to wounding
1.83 2.61e-02 GO:0006810 transport
5.65 2.75e-02 GO:0051346 negative regulation of hydrolase activity
42.45 2.89e-02 GO:0031640 killing of cells of other organism
9.59 3.13e-02 GO:0033500 carbohydrate homeostasis
9.59 3.13e-02 GO:0042593 glucose homeostasis
18.87 4.41e-02 GO:0050819 negative regulation of coagulation
6.05 4.64e-02 GO:0006814 sodium ion transport
3.46 4.92e-02 GO:0009719 response to endogenous stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.48 5.64e-09 GO:0005792 microsome
6.31 8.96e-09 GO:0042598 vesicular fraction
2.72 2.39e-08 GO:0005576 extracellular region
3.49 3.11e-07 GO:0005624 membrane fraction
3.34 8.93e-07 GO:0005626 insoluble fraction
2.96 1.56e-06 GO:0000267 cell fraction
3.55 5.54e-06 GO:0005615 extracellular space
3.11 7.57e-06 GO:0044421 extracellular region part
2.86 4.44e-05 GO:0005783 endoplasmic reticulum
2.30 6.94e-05 GO:0044459 plasma membrane part
5.80 4.66e-04 GO:0016324 apical plasma membrane
1.71 1.16e-03 GO:0071944 cell periphery
4.76 1.28e-03 GO:0045177 apical part of cell
4.93 2.17e-03 GO:0016323 basolateral plasma membrane
1.69 2.59e-03 GO:0005886 plasma membrane
10.08 3.91e-03 GO:0005903 brush border
12.70 6.00e-03 GO:0031526 brush border membrane
6.80 1.09e-02 GO:0031253 cell projection membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
40.52 1.05e-10 GO:0015020 glucuronosyltransferase activity
6.15 8.12e-08 GO:0022804 active transmembrane transporter activity
7.79 9.52e-07 GO:0015291 secondary active transmembrane transporter activity
3.47 1.28e-06 GO:0022857 transmembrane transporter activity
1.73 3.82e-06 GO:0003824 catalytic activity
7.67 4.26e-06 GO:0030414 peptidase inhibitor activity
6.33 4.47e-06 GO:0016757 transferase activity, transferring glycosyl groups
3.02 9.24e-06 GO:0005215 transporter activity
5.65 1.99e-05 GO:0004857 enzyme inhibitor activity
6.57 2.65e-05 GO:0061134 peptidase regulator activity
9.44 2.87e-05 GO:0004867 serine-type endopeptidase inhibitor activity
13.21 4.01e-05 GO:0005496 steroid binding
3.01 1.45e-04 GO:0022892 substrate-specific transporter activity
3.18 1.50e-04 GO:0022891 substrate-specific transmembrane transporter activity
4.25 1.60e-04 GO:0008289 lipid binding
6.86 1.72e-04 GO:0004866 endopeptidase inhibitor activity
7.68 1.98e-04 GO:0004497 monooxygenase activity
6.61 2.49e-04 GO:0061135 endopeptidase regulator activity
6.57 2.64e-04 GO:0031406 carboxylic acid binding
8.26 3.93e-04 GO:0008194 UDP-glycosyltransferase activity
11.76 5.53e-04 GO:0033293 monocarboxylic acid binding
7.43 9.46e-04 GO:0015293 symporter activity
9.37 2.57e-03 GO:0015294 solute:cation symporter activity
9.01 3.35e-03 GO:0015081 sodium ion transmembrane transporter activity
2.88 5.88e-03 GO:0016491 oxidoreductase activity
14.15 6.70e-03 GO:0015103 inorganic anion transmembrane transporter activity
5.83 6.78e-03 GO:0016758 transferase activity, transferring hexosyl groups
22.01 7.33e-03 GO:0008514 organic anion transmembrane transporter activity
6.66 7.41e-03 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
5.06 8.23e-03 GO:0022890 inorganic cation transmembrane transporter activity
6.29 1.12e-02 GO:0046873 metal ion transmembrane transporter activity
7.30 1.32e-02 GO:0005342 organic acid transmembrane transporter activity
37.15 1.46e-02 GO:0008271 secondary active sulfate transmembrane transporter activity
11.80 1.66e-02 GO:0043498 cell surface binding
5.79 2.02e-02 GO:0008509 anion transmembrane transporter activity
99.05 2.71e-02 GO:0003973 (S)-2-hydroxy-acid oxidase activity
2.75 2.85e-02 GO:0015075 ion transmembrane transporter activity
29.72 3.08e-02 GO:0015116 sulfate transmembrane transporter activity
5.39 3.31e-02 GO:0015077 monovalent inorganic cation transmembrane transporter activity
9.91 3.87e-02 GO:0002020 protease binding
27.02 4.20e-02 GO:0001972 retinoic acid binding