• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.599

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_+_86578225	17.806		Asprv1	aspartic peptidase, retroviral-like 1
chr6_+_86578167	17.273	NM_026414	Asprv1	aspartic peptidase, retroviral-like 1
chr6_+_86578269	14.454		Asprv1	aspartic peptidase, retroviral-like 1
chr6_+_86578550	13.893		Asprv1	aspartic peptidase, retroviral-like 1
chr11_-_77538789	12.471	NM_009965	Cryba1	crystallin, beta A1
chr14_-_44579933	12.440	NM_001011876	Ang6	angiogenin, ribonuclease A family, member 6
chr10_+_96944961	11.349	NM_007833	Dcn	decorin
chr16_+_35002066	10.667		Mylk	myosin, light polypeptide kinase
chr1_+_45401303	10.300		Col3a1	collagen, type III, alpha 1
chrX_+_70728994	10.093		Bgn	biglycan
chrX_+_70728939	10.028	NM_007542	Bgn	biglycan
chr2_-_125142715	9.998		Fbn1	fibrillin 1
chr10_+_43198945	9.597	NM_199028	Bend3	BEN domain containing 3
chr10_+_96945057	9.505		Dcn	decorin
chr6_+_55286292	9.356	NM_007472	Aqp1	aquaporin 1
chr3_-_92491103	9.200	NM_027137	Lce1d	late cornified envelope 1D
chr3_+_101266000	9.164		Igsf3	immunoglobulin superfamily, member 3
chr5_-_135422730	8.868		Cldn4	claudin 4
chr7_-_31861665	8.846	NM_008557	Fxyd3	FXYD domain-containing ion transport regulator 3
chr5_-_135422795	8.749	NM_009903	Cldn4	claudin 4
chr3_+_122598292	8.546	NM_007980	Fabp2	fatty acid binding protein 2, intestinal
chr1_+_109258889	8.317	NM_025867	Serpinb11	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chr5_-_135422780	8.287		Cldn4	claudin 4
chr4_-_34830178	8.238	NM_013889	Zfp292	zinc finger protein 292
chr1_+_59543450	8.170
chr7_+_95578782	8.068	NM_028238	Rab38	RAB38, member of RAS oncogene family
chr8_+_22675857	8.041	NM_001177522	Gm14850	predicted gene 14850
chr1_+_45401659	8.022		Col3a1	collagen, type III, alpha 1
chr15_-_58010344	7.953
chr7_+_71330344	7.780	NM_018752	Trpm1	transient receptor potential cation channel, subfamily M, member 1
chr9_+_50302624	7.720	NM_029639	1600029D21Rik	RIKEN cDNA 1600029D21 gene
chr16_-_5132502	7.705	NM_008909	Ppl	periplakin
chr2_+_31805852	7.669		Aif1l	allograft inflammatory factor 1-like
chr1_+_152166546	7.652	NM_001159730 NM_024458	Pdc	phosducin
chr2_-_127555628	7.615	NM_145532	Mall	mal, T-cell differentiation protein-like
chr17_+_75404893	7.486		Ltbp1	latent transforming growth factor beta binding protein 1
chr4_-_60594469	7.382		Mup1	major urinary protein 1
chr17_+_29629987	7.282		Pim1	proviral integration site 1
chr6_-_47544925	7.208	NM_001146689 NM_007971	Ezh2	enhancer of zeste homolog 2 (Drosophila)
chr17_+_47605313	7.199		AI661453	expressed sequence AI661453
chr12_+_25516433	7.198	NM_001083341 NM_026037	Mboat2	membrane bound O-acyltransferase domain containing 2
chr14_+_35188650	7.041	NM_153127	Mmrn2	multimerin 2
chr10_+_43298969	6.988	NM_009846	Cd24a	CD24a antigen
chr8_+_22766238	6.862	NM_001167790	Defa3 Defa17	defensin, alpha, 3 defensin, alpha, 17
chr18_-_61195852	6.839	NM_009880	Cdx1	caudal type homeobox 1
chr7_-_31758185	6.776		Lsr	lipolysis stimulated lipoprotein receptor
chr2_-_65076471	6.753		Cobll1	Cobl-like 1
chr14_+_102239673	6.699		Lmo7	LIM domain only 7
chr14_+_102129129	6.695	NM_201529	Lmo7	LIM domain only 7
chr17_+_75404865	6.630	NM_019919	Ltbp1	latent transforming growth factor beta binding protein 1
chr3_-_92582820	6.585	NM_029667	Lce1i	late cornified envelope 1I
chr5_-_101001209	6.580	NM_139198	Plac8	placenta-specific 8
chr10_-_13108775	6.570	NM_001195066	Phactr2	phosphatase and actin regulator 2
chr5_-_123632567	6.563	NM_008277	Hpd	4-hydroxyphenylpyruvic acid dioxygenase
chr8_+_22844965	6.524	NM_007852 NM_001024225	Defa3 Defa6 Defa24	defensin, alpha, 3 defensin, alpha, 6 defensin, alpha, 24
chr5_-_101001191	6.518		Plac8	placenta-specific 8
chr2_-_65076584	6.466	NM_027225 NM_177025	Cobll1	Cobl-like 1
chr4_+_11685294	6.303	NM_019753	Cdh17	cadherin 17
chr3_-_116126932	6.294	NM_001080818 NM_001173553	Cdc14a	CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr4_-_60594496	6.264		Mup1	major urinary protein 1
chr3_-_144595486	6.226	NM_001033199	AI747448	expressed sequence AI747448
chr11_-_116668593	6.222
chr12_-_77896363	6.189		Gpx2	glutathione peroxidase 2
chr7_-_81429262	6.184		Slco3a1	solute carrier organic anion transporter family, member 3a1
chr12_+_77182878	6.085		Syne2	synaptic nuclear envelope 2
chr9_+_46048812	6.084	NM_007468	Apoa4	apolipoprotein A-IV
chr19_+_55969810	6.069	NM_001142924	Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box
chr1_-_71686889	6.037		Fn1	fibronectin 1
chr3_-_144637974	5.950	NM_207208	Clca6	chloride channel calcium activated 6
chr5_-_87964170	5.948		Sult1b1	sulfotransferase family 1B, member 1
chr9_+_46048993	5.851		Apoa4	apolipoprotein A-IV
chr6_-_52190771	5.841	NM_001122950	Hoxa10	homeobox A10
chr2_-_62249869	5.828		Dpp4	dipeptidylpeptidase 4
chr3_+_59835700	5.797	NM_023383	Aadac	arylacetamide deacetylase (esterase)
chr7_+_148153974	5.776	NM_001112715	Ifitm1	interferon induced transmembrane protein 1
chrX_+_160600108	5.766		Ace2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr12_-_77896410	5.662		Gpx2	glutathione peroxidase 2
chr12_-_77896534	5.655	NM_030677	Gpx2	glutathione peroxidase 2
chr12_+_31950252	5.621		Lamb1	laminin B1
chr7_+_148153327	5.612	NM_026820	Ifitm1	interferon induced transmembrane protein 1
chr19_+_34175422	5.590	NM_023903	Lipm	lipase, family member M
chr11_-_106128935	5.576	NM_031878	Smarcd2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr17_-_79420125	5.477	NM_001171004 NM_029239	Prkd3	protein kinase D3
chr2_+_144649401	5.466	NM_025490	1700010M22Rik	RIKEN cDNA 1700010M22 gene
chr15_-_101543318	5.436	NM_027011	Krt5	keratin 5
chr1_+_90062617	5.424		Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5
chr14_-_51815597	5.371	NM_007449	Ang2	angiogenin, ribonuclease A family, member 2
chr1_+_90062550	5.318	NM_201643	Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5
chr3_-_75760820	5.286		Golim4	golgi integral membrane protein 4
chr11_+_96790581	5.286	NM_146026	Prr15l	proline rich 15-like
chr2_-_140215417	5.247	NM_001033296	Sel1l2	sel-1 suppressor of lin-12-like 2 (C. elegans)
chr11_-_86621130	5.240	NM_026191	Dhx40	DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr3_+_135488617	5.232	NM_001135149 NM_001135150	Slc39a8	solute carrier family 39 (metal ion transporter), member 8
chr1_+_24184448	5.214	NM_007740	Col9a1	collagen, type IX, alpha 1
chr4_+_11685359	5.211		Cdh17	cadherin 17
chr11_-_86621074	5.156		Dhx40	DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr8_-_120195414	5.131	NM_028725	Sdr42e1	short chain dehydrogenase/reductase family 42E, member 1
chr15_+_82129383	5.128	NM_029066	Wbp2nl	WBP2 N-terminal like
chr8_+_94881694	5.077	NM_018826	Irx5	Iroquois related homeobox 5 (Drosophila)
chr11_+_67013553	5.048	NM_030679	Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult
chr3_-_57379600	4.991	NM_133784	Wwtr1	WW domain containing transcription regulator 1
chr4_-_61179982	4.982		Mup1	major urinary protein 1
chr12_+_31950097	4.963	NM_008482	Lamb1	laminin B1
chr3_-_92474213	4.942	NM_028625	Lce1a2	late cornified envelope 1A2
chr3_+_96025040	4.911	NM_178214	Hist2h2be	histone cluster 2, H2be
chr3_-_40659202	4.911	NM_001129886	Gm10731	predicted gene 10731
chr6_+_68375560	4.828		Igkv16-104	immunoglobulin kappa variable 16-104
chr5_-_105539282	4.827	NM_172777	Gbp9	guanylate-binding protein 9
chr10_+_79451332	4.819	NM_007725	Cnn2	calponin 2
chr17_+_28667805	4.769	NM_026290	4930511I11Rik	RIKEN cDNA 4930511I11 gene
chr1_-_58752798	4.741	NM_175370	Als2cr12	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 (human)
chr10_-_126807486	4.727	NM_010565	Inhbc	inhibin beta-C
chr10_-_61441817	4.694		Col13a1	collagen, type XIII, alpha 1
chr17_-_84246141	4.689		Haao	3-hydroxyanthranilate 3,4-dioxygenase
chr6_+_29685467	4.654	NM_176996	Smo	smoothened homolog (Drosophila)
chr17_-_84246073	4.652	NM_025325	Haao	3-hydroxyanthranilate 3,4-dioxygenase
chr13_-_3803547	4.649	NM_027416	Calml3	calmodulin-like 3
chr11_+_102006824	4.640		Nags	N-acetylglutamate synthase
chr7_-_111161213	4.630	NM_147084	Olfr639	olfactory receptor 639
chr15_-_58046380	4.598		Fbxo32	F-box protein 32
chr4_-_58219368	4.558	NM_022814	Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr13_-_41454331	4.526		Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9
chr10_-_61441842	4.522	NM_007731	Col13a1	collagen, type XIII, alpha 1
chr12_+_21117704	4.522		Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr11_+_108781661	4.514	NM_015732	Axin2	axin2
chr11_+_102006847	4.453		Nags	N-acetylglutamate synthase
chr16_+_22951183	4.416		Hrg	histidine-rich glycoprotein
chr11_+_46218231	4.396	NM_001013783	Fam71b	family with sequence similarity 71, member B
chr1_+_36818669	4.386	NM_009539	Zap70	zeta-chain (TCR) associated protein kinase
chrX_-_130696466	4.385	NM_183319	Xkrx	X Kell blood group precursor related X linked
chr15_-_82624668	4.333	NM_029562	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26
chr14_-_98568744	4.305	NM_001038610 NM_007826	Dach1	dachshund 1 (Drosophila)
chr4_-_149377238	4.256		H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr11_-_99949426	4.241	NM_001159374	Krt32	keratin 32
chr7_+_119167048	4.226		Usp47	ubiquitin specific peptidase 47
chr3_+_92736900	4.212	NM_025501	Lce3b	late cornified envelope 3B
chr7_+_147949637	4.202		Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1
chr3_-_57379831	4.194	NM_001168281	Wwtr1	WW domain containing transcription regulator 1
chr12_-_56087322	4.171	NM_013815	Baz1a	bromodomain adjacent to zinc finger domain 1A
chr5_+_32541456	4.165	NM_001081407	Plb1	phospholipase B1
chr1_+_193730645	4.161	NM_009579	Slc30a1	solute carrier family 30 (zinc transporter), member 1
chr11_+_87881747	4.159	NM_016686	Vezf1	vascular endothelial zinc finger 1
chr11_+_67051530	4.127	NM_010855	Myh4	myosin, heavy polypeptide 4, skeletal muscle
chr12_+_114378368	4.127	NM_024223	Crip2	cysteine rich protein 2
chr5_+_100408033	4.090		4930524J08Rik	RIKEN cDNA 4930524J08 gene
chr19_+_20676453	4.071	NM_013467	Aldh1a1	aldehyde dehydrogenase family 1, subfamily A1
chr16_+_22951144	4.058	NM_053176	Hrg	histidine-rich glycoprotein
chr1_-_157589156	4.051	NM_010712	Lhx4	LIM homeobox protein 4
chr7_+_97535516	4.047		Sytl2	synaptotagmin-like 2
chr7_-_112936063	4.020	NM_001162943	Dchs1	dachsous 1 (Drosophila)
chr15_-_82624638	4.018		Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26
chr13_+_49703402	4.016	NM_008760	Ogn	osteoglycin
chr14_+_27852148	4.013	NM_134437	Il17rd	interleukin 17 receptor D
chr7_-_123182257	4.009	NM_001025559	Sox6	SRY-box containing gene 6
chr3_-_92452189	3.977	NM_025984	Lce1a1	late cornified envelope 1A1
chr4_-_43496556	3.970	NM_019436	Sit1	suppression inducing transmembrane adaptor 1
chr16_+_45094163	3.965	NM_026439	Ccdc80	coiled-coil domain containing 80
chr14_+_49791899	3.933	NM_001081430	Naa30	N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr14_+_22319075	3.924	NM_017479	Myst4	MYST histone acetyltransferase monocytic leukemia 4
chr3_+_92483168	3.914	NM_028622	Lce1c	late cornified envelope 1C
chr1_-_165243608	3.901		Prrx1	paired related homeobox 1
chr14_-_73762324	3.894		Itm2b	integral membrane protein 2B
chrX_+_160578411	3.885	NM_027286	Ace2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr12_+_114378688	3.881		Crip2	cysteine rich protein 2
chr8_-_112486020	3.877	NM_028584 NM_212447	Marveld3	MARVEL (membrane-associating) domain containing 3
chr6_-_78418862	3.877	NM_011260	Reg3g	regenerating islet-derived 3 gamma
chr7_+_27904997	3.865		Cyp2f2	cytochrome P450, family 2, subfamily f, polypeptide 2
chr15_-_58046428	3.865	NM_026346	Fbxo32	F-box protein 32
chr12_+_18521315	3.858	NM_001033157	5730507C01Rik	RIKEN cDNA 5730507C01 gene
chr3_-_98567014	3.822	NM_001161742 NM_001161743	Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
chr9_+_107897371	3.809	NM_001122635	Cdhr4	cadherin-related family member 4
chr2_-_143688908	3.777	NM_009751	Bfsp1	beaded filament structural protein 1, in lens-CP94
chr4_+_135842003	3.770		Zfp46	zinc finger protein 46
chr7_+_125743753	3.769		Tmc5	transmembrane channel-like gene family 5
chr3_-_116126853	3.769		Cdc14a	CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chrX_-_35774388	3.752		Lamp2	lysosomal-associated membrane protein 2
chr7_+_97535490	3.719	NM_001040087 NM_001040088	Sytl2	synaptotagmin-like 2
chr14_-_118450875	3.710	NM_010024	Dct	dopachrome tautomerase
chr18_-_58169723	3.670		Fbn2	fibrillin 2
chr6_-_52184909	3.664	NM_008263	Hoxa10	homeobox A10
chr17_+_30763879	3.659	NM_013811	Dnahc8	dynein, axonemal, heavy chain 8
chr5_+_25021884	3.655	NM_198621	Cct8l1	chaperonin containing TCP1, subunit 8 (theta)-like 1
chr4_-_132818988	3.643	NM_031393	Sytl1	synaptotagmin-like 1
chr15_-_75950624	3.640	NM_144848	Eppk1 BC024139	epiplakin 1 cDNA sequence BC024139
chr4_+_140976693	3.635	NM_013868	Hspb7	heat shock protein family, member 7 (cardiovascular)
chr7_-_133819870	3.632	NM_133670	Sult1a1	sulfotransferase family 1A, phenol-preferring, member 1
chr12_-_104594210	3.629	NM_023049	Asb2	ankyrin repeat and SOCS box-containing 2
chr10_+_5959030	3.604		Zbtb2	zinc finger and BTB domain containing 2
chr1_+_92100572	3.601	NM_007722	Cxcr7	chemokine (C-X-C motif) receptor 7
chr15_-_98701613	3.590	NM_001033276	Mll2	myeloid/lymphoid or mixed-lineage leukemia 2
chr7_+_87343467	3.583		Sema4b	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr4_+_43521765	3.553		Car9	carbonic anhydrase 9
chr19_-_39815590	3.545	NM_001039555	Cyp2c68	cytochrome P450, family 2, subfamily c, polypeptide 68
chr2_+_174586283	3.541		Edn3	endothelin 3
chr16_+_45094196	3.513		Ccdc80	coiled-coil domain containing 80
chr4_+_43888373	3.511	NM_016678	Reck	reversion-inducing-cysteine-rich protein with kazal motifs
chr7_+_27904968	3.502	NM_007817	Cyp2f2	cytochrome P450, family 2, subfamily f, polypeptide 2
chr2_-_62249889	3.495		Dpp4	dipeptidylpeptidase 4
chr7_+_97497207	3.495	NM_001040085 NM_031394	Sytl2	synaptotagmin-like 2
chr16_+_35001358	3.486		Mylk	myosin, light polypeptide kinase

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
1.31	5.64e-04	GO:0007275	multicellular organismal development
1.27	4.37e-03	GO:0032502	developmental process
1.34	3.49e-02	GO:0048513	organ development

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.53	2.44e-08	GO:0005576	extracellular region
1.73	6.63e-08	GO:0044421	extracellular region part
1.68	9.44e-05	GO:0005615	extracellular space
2.02	8.48e-04	GO:0005578	proteinaceous extracellular matrix
2.66	1.32e-03	GO:0044420	extracellular matrix part
1.89	3.11e-03	GO:0031012	extracellular matrix
7.97	9.23e-03	GO:0035098	ESC/E(Z) complex
3.87	2.57e-02	GO:0045178	basal part of cell

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.12	7.86e-05	GO:0005488	binding
1.19	5.09e-04	GO:0005515	protein binding
1.41	5.61e-04	GO:0046914	transition metal ion binding
2.20	3.81e-03	GO:0061134	peptidase regulator activity
4.12	4.93e-02	GO:0005201	extracellular matrix structural constituent