Motif ID: LHX3,4.p2

Z-value: 1.060


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
Lhx3 16871 LIM homeobox protein 3
Lhx4 16872 LIM homeobox protein 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx3chr2_-_260620080.215.2e-03Click!
Lhx4chr1_-_157589156-0.082.7e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_48571942 54.778 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr17_-_48572043 49.113 NM_009694
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr6_+_124254668 16.095 NM_001170395
NM_053094
Cd163

CD163 antigen

chr6_+_4483741 12.999 Col1a2
collagen, type I, alpha 2
chr11_+_67051128 11.021 Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr11_+_67611772 10.130 NM_001013013
Dhrs7c
dehydrogenase/reductase (SDR family) member 7C
chr3_+_101949321 9.334 Casq2
calsequestrin 2
chr7_-_52359079 9.155 NM_010189
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr5_-_17394564 9.042 Cd36
CD36 antigen
chr10_-_61960613 8.638 Srgn
serglycin
chr17_-_74242984 8.504 Xdh
xanthine dehydrogenase
chr6_-_3349415 8.373 Samd9l
sterile alpha motif domain containing 9-like
chr5_-_17394776 8.025 NM_001159558
Cd36
CD36 antigen
chr17_-_34999068 7.901 Cfb
complement factor B
chr6_+_145882641 7.895 NM_010656
Sspn
sarcospan
chr1_+_19093102 7.836 NM_153154
Tcfap2d
transcription factor AP-2, delta
chr2_+_69508174 7.786 NM_001081087
Kbtbd10
kelch repeat and BTB (POZ) domain containing 10
chr17_-_34999458 7.761 NM_001142706
NM_008198
Cfb

complement factor B

chr16_-_11220854 7.578 Gspt1
G1 to S phase transition 1
chr10_+_96945057 7.536 Dcn
decorin
chr11_+_67051530 7.255 NM_010855
Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr10_-_61970481 7.212 NM_011157
Srgn
serglycin
chr17_+_34442808 6.968 NM_010382
H2-Eb1
histocompatibility 2, class II antigen E beta
chrX_+_130385546 6.880 NM_022322
Tnmd
tenomodulin
chrX_+_130385690 6.757 Tnmd
tenomodulin
chr8_-_64381465 6.585 NM_001081390
Palld
palladin, cytoskeletal associated protein
chr15_+_3230053 6.554


chr10_-_62666659 6.415 NM_182992
Mypn
myopalladin
chr9_-_44610921 6.137 Ttc36
tetratricopeptide repeat domain 36
chr18_+_57628139 6.034 NM_001134697
Ctxn3
cortexin 3
chr17_+_34442837 5.808 H2-Eb1
histocompatibility 2, class II antigen E beta
chr12_-_74147698 5.739 NM_009189
Six1
sine oculis-related homeobox 1 homolog (Drosophila)
chr6_+_4484651 5.728 Col1a2
collagen, type I, alpha 2
chr8_+_55635683 5.634 NM_029569
Asb5
ankyrin repeat and SOCs box-containing 5
chr1_-_164796660 5.595 NM_010231
Fmo1
flavin containing monooxygenase 1
chr2_-_28771940 5.586 NM_019446
NM_001164186
Barhl1

BarH-like 1 (Drosophila)

chr15_-_103395483 5.537 NM_008134
Glycam1
glycosylation dependent cell adhesion molecule 1
chr13_-_60278859 5.466 NM_008086
Gas1
growth arrest specific 1
chr15_+_58731646 5.451 Rnf139
ring finger protein 139
chr10_+_96944961 5.433 NM_007833
Dcn
decorin
chr7_-_91763744 5.312 Zfand6
zinc finger, AN1-type domain 6
chr1_-_164796609 5.311 Fmo1
flavin containing monooxygenase 1
chr4_-_61179982 5.297 Mup1
major urinary protein 1
chr9_-_110649625 5.214 NM_011199
Pth1r
parathyroid hormone 1 receptor
chr4_-_60594496 5.210 Mup1
major urinary protein 1
chr12_-_74147683 5.200 Six1
sine oculis-related homeobox 1 homolog (Drosophila)
chr8_+_55635768 5.085 Asb5
ankyrin repeat and SOCs box-containing 5
chr13_+_49639847 5.083 Aspn
asporin
chr4_-_60594469 5.029 Mup1
major urinary protein 1
chr3_-_129035406 5.023 NM_007934
Enpep
glutamyl aminopeptidase
chr7_-_80686630 4.904 NM_001081345
Chd2
chromodomain helicase DNA binding protein 2
chr2_-_73418334 4.856 NM_007389
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr13_+_23931302 4.849 NM_001164743
NM_134069
Slc17a3

solute carrier family 17 (sodium phosphate), member 3

chr3_+_137949734 4.846 Adh1
alcohol dehydrogenase 1 (class I)
chr3_-_112959644 4.824 NM_001190403
NM_001190404
Amy2b

amylase 2b

chr11_+_87895626 4.806 Vezf1
vascular endothelial zinc finger 1
chr1_-_72330767 4.738 NM_023523
Pecr
peroxisomal trans-2-enoyl-CoA reductase
chr9_-_44611033 4.736 NM_138951
Ttc36
tetratricopeptide repeat domain 36
chrM_-_13886 4.674


chr11_+_76718046 4.665 NM_025655
Tmigd1
transmembrane and immunoglobulin domain containing 1
chr5_-_69933835 4.653 NM_023784
Yipf7
Yip1 domain family, member 7
chr2_+_74536666 4.648 Hoxd9
homeobox D9
chr5_+_7960430 4.636 NM_054098
Steap4
STEAP family member 4
chr9_-_44611055 4.601 Ttc36
tetratricopeptide repeat domain 36
chr2_+_35413977 4.586 NM_001114125
Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr2_+_132673469 4.560 NM_025646
Crls1
cardiolipin synthase 1
chr6_-_87793459 4.558 Cnbp
cellular nucleic acid binding protein
chr1_+_89951985 4.517 NM_201641
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr4_+_94405963 4.496 NM_013690
Tek
endothelial-specific receptor tyrosine kinase
chr6_-_3349470 4.483 NM_010156
Samd9l
sterile alpha motif domain containing 9-like
chr7_-_56099011 4.362 NM_013808
Csrp3
cysteine and glycine-rich protein 3
chr7_-_125629996 4.344 Itpripl2
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr3_+_116265890 4.210 NM_027321
NM_175413
Lrrc39

leucine rich repeat containing 39

chr16_-_88563421 4.018 NM_018778
Cldn8
claudin 8
chr17_-_14831233 4.011 Thbs2
thrombospondin 2
chr2_+_74707394 3.992 Mtx2
metaxin 2
chr6_+_29809595 3.935 NM_001171001
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr12_-_105711324 3.842 NM_010351
Gsc
goosecoid homeobox
chr10_-_117252126 3.817


chr2_-_73291933 3.797 Wipf1
WAS/WASL interacting protein family, member 1
chr1_-_71632834 3.793 Fn1
fibronectin 1
chr10_-_116786025 3.763 Cpsf6
cleavage and polyadenylation specific factor 6
chr14_+_27813547 3.743 NM_010420
Hesx1
homeobox gene expressed in ES cells
chr19_-_39961258 3.735 NM_001104525
Cyp2c69
cytochrome P450, family 2, subfamily c, polypeptide 69
chr6_+_54839147 3.712 Znrf2
zinc and ring finger 2
chr15_+_10106992 3.693 NM_011169
Prlr
prolactin receptor
chr16_+_43247396 3.644 NM_019778
NM_181058
Zbtb20

zinc finger and BTB domain containing 20

chr8_+_46970860 3.641 Pdlim3
PDZ and LIM domain 3
chr12_+_82049290 3.613 Srsf5
serine/arginine-rich splicing factor 5
chr10_-_106931783 3.584 NM_008657
Myf6
myogenic factor 6
chr7_-_110976499 3.580 Hbb-b1
hemoglobin, beta adult major chain
chr13_+_49639799 3.571 NM_001172481
NM_025711
Aspn

asporin

chr9_+_96159123 3.547 NM_001184709
Tfdp2
transcription factor Dp 2
chr9_-_15105965 3.530 NM_133732
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr8_-_42140113 3.523 NM_001005864
Mtus1
mitochondrial tumor suppressor 1
chr10_-_127613494 3.509 Rbms2
RNA binding motif, single stranded interacting protein 2
chr11_-_98862163 3.472 Top2a
topoisomerase (DNA) II alpha
chr1_+_45390415 3.420 Col3a1
collagen, type III, alpha 1
chr6_+_37820779 3.402 NM_145076
Trim24
tripartite motif-containing 24
chr6_-_3444484 3.391 NM_178899
Hepacam2
HEPACAM family member 2
chr7_-_56892061 3.368 NM_001005232
Dbx1
developing brain homeobox 1
chr6_+_83290548 3.346 Mobkl1b
MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr4_+_129526991 3.340


chr10_+_87321789 3.337 NM_001111275
NM_010512
Igf1

insulin-like growth factor 1

chr17_-_56144975 3.329 NM_145934
Stap2
signal transducing adaptor family member 2
chr11_-_94154354 3.326 Luc7l3
LUC7-like 3 (S. cerevisiae)
chr10_-_36858671 3.313 NM_008538
Marcks
myristoylated alanine rich protein kinase C substrate
chr19_-_39887217 3.302 NM_010004
Cyp2c40
cytochrome P450, family 2, subfamily c, polypeptide 40
chr9_-_15105864 3.296 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr10_+_101621491 3.276 NM_001162368
Mgat4c
4930402I19Rik
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
RIKEN cDNA 4930402I19 gene
chr9_+_92502076 3.255


chr6_-_3295980 3.225 9530028C05
hypothetical protein 9530028C05
chr15_+_102839909 3.218 NM_010465
Hoxc6
homeobox C6
chr17_-_36169460 3.209


chrX_+_147024463 3.176 NM_008824
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr17_-_14831262 3.170 NM_011581
Thbs2
thrombospondin 2
chr11_+_67013553 3.169 NM_030679
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr4_-_147183894 3.150 NM_001127189
Gm13157
2610036A22Rik
predicted gene 13157
RIKEN cDNA 2610036A22 gene
chr4_-_82151180 3.120 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr7_-_53922712 3.096 NM_001136084
Tph1
tryptophan hydroxylase 1
chrX_+_154137193 3.084 Smpx
small muscle protein, X-linked
chr16_+_45224449 3.082 NM_001037719
NM_177584
Btla

B and T lymphocyte associated

chr6_-_69367406 3.065 Igkv4-68
immunoglobulin kappa variable 4-68
chr15_+_31154176 3.061 Dap
death-associated protein
chr11_+_66984528 3.050 NM_001039545
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr4_+_34841027 3.023 NM_009889
Cga
glycoprotein hormones, alpha subunit
chr8_+_46970814 3.016 NM_016798
Pdlim3
PDZ and LIM domain 3
chr9_+_108241599 3.007 NM_008160
Gpx1
glutathione peroxidase 1
chr2_+_36086059 2.997 Ptgs1
prostaglandin-endoperoxide synthase 1
chr6_+_4471231 2.988 Col1a2
collagen, type I, alpha 2
chr3_-_27316628 2.953 Fndc3b
fibronectin type III domain containing 3B
chr2_+_152106052 2.917 Csnk2a1
casein kinase 2, alpha 1 polypeptide
chr7_-_22813915 2.905 NM_001166839
NM_001167169
NM_001167168
NM_001166746
Gm4172
Gm4179
Gm4220
Vmn1r111
predicted gene 4172
predicted gene 4179
predicted gene 4220
vomeronasal 1 receptor 111
chr17_-_36169573 2.900 NM_010398
H2-T23
histocompatibility 2, T region locus 23
chr5_-_72692122 2.881 Corin
corin
chr19_-_44471675 2.880 Scd1
stearoyl-Coenzyme A desaturase 1
chr17_-_14831095 2.865 Thbs2
thrombospondin 2
chr1_-_72905107 2.860 Igfbp5
insulin-like growth factor binding protein 5
chr7_-_20960758 2.858 NM_001166713
NM_001166751
Gm5728
Gm8660
predicted gene 5728
predicted gene 8660
chr2_-_155771090 2.829 NM_008109
Gdf5
growth differentiation factor 5
chr17_-_14831058 2.812 Thbs2
thrombospondin 2
chr4_+_116265582 2.806 Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr6_-_68967061 2.800


chr3_-_67319413 2.775 NM_001164763
Rarres1
retinoic acid receptor responder (tazarotene induced) 1
chr19_-_44472087 2.772 Scd1
stearoyl-Coenzyme A desaturase 1
chr14_+_119380708 2.768


chr1_+_169528838 2.700 Rxrg
retinoid X receptor gamma
chr1_-_140071630 2.696 Ptprc
protein tyrosine phosphatase, receptor type, C
chr7_+_148127289 2.674 Athl1
ATH1, acid trehalase-like 1 (yeast)
chr17_+_13208071 2.666 Sod2
superoxide dismutase 2, mitochondrial
chr1_-_140071818 2.655 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr6_-_87793898 2.646 Cnbp
cellular nucleic acid binding protein
chr7_-_21095882 2.616 NM_001166737
Vmn1r103
vomeronasal 1 receptor 103
chr14_+_27707789 2.598 NM_001170748
NM_080856
Asb14

ankyrin repeat and SOCS box-containing 14

chr15_+_31154137 2.596 NM_146057
Dap
death-associated protein
chr3_-_103546233 2.555 Hipk1
homeodomain interacting protein kinase 1
chr11_-_106175797 2.525 NM_008339
Cd79b
CD79B antigen
chr2_+_112307393 2.517 2900064A13Rik
RIKEN cDNA 2900064A13 gene
chr8_+_116657473 2.513 NM_024437
NM_024446
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr1_-_141982814 2.500 Cfh
complement component factor h
chr10_+_101621712 2.493 NM_001162369
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr10_+_23614493 2.485 NM_011704
Vnn1
vanin 1
chr3_+_88342459 2.475 Mex3a
mex3 homolog A (C. elegans)
chrX_-_136406046 2.474 NM_001193309
NM_029413
Morc4

microrchidia 4

chr9_-_103256690 2.471 Cdv3
carnitine deficiency-associated gene expressed in ventricle 3
chrX_-_103207106 2.461 NM_001190409
NM_025952
Magt1

magnesium transporter 1

chr6_-_115568804 2.434 Raf1
v-raf-leukemia viral oncogene 1
chr1_+_141398282 2.361 NM_031164
F13b
coagulation factor XIII, beta subunit
chrX_+_154137114 2.360 Smpx
small muscle protein, X-linked
chr11_-_46520535 2.346 Timd2
T-cell immunoglobulin and mucin domain containing 2
chr10_-_118293979 2.337 Dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr3_+_89866717 2.334 NM_028567
1700094D03Rik
RIKEN cDNA 1700094D03 gene
chr7_-_23628623 2.332 NM_001166758
Vmn1r159
vomeronasal 1 receptor 159
chr6_-_130287518 2.327 NM_010648
Klra3
killer cell lectin-like receptor, subfamily A, member 3
chr7_-_21838802 2.324 NM_001166715
Vmn1r120
vomeronasal 1 receptor 120
chr12_-_102988596 2.306


chr1_+_90203286 2.305 NM_134252
Trpm8
transient receptor potential cation channel, subfamily M, member 8
chr13_+_27334298 2.287 NM_008865
Prl3b1
prolactin family 3, subfamily b, member 1
chr9_+_44206431 2.270 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr7_-_110976314 2.264 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr7_-_23284696 2.260 NM_001166712
Vmn1r151
vomeronasal 1 receptor 151
chr2_-_38640034 2.252 NM_001159548
NM_001159549
Nr6a1

nuclear receptor subfamily 6, group A, member 1

chr4_+_147320793 2.252 2510039O18Rik
RIKEN cDNA 2510039O18 gene
chr11_-_100068823 2.244 NM_016958
Krt14
keratin 14
chr7_+_22296798 2.243 NM_001166846
NM_001166848
NM_001166849
NM_001166850
NM_001166753
NM_001166759
Vmn1r110
Vmn1r130
Vmn1r137
Vmn1r165
Vmn1r155
Vmn1r107
vomeronasal 1 receptor 110
vomeronasal 1 receptor 130
vomeronasal 1 receptor 137
vomeronasal 1 receptor 165
vomeronasal 1 receptor 155
vomeronasal 1 receptor 107
chr11_+_60351469 2.229 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr13_+_27149438 2.225 NM_001163530
NM_011164
Prl

prolactin

chr9_-_96632093 2.218 NM_175537
Zbtb38
zinc finger and BTB domain containing 38
chr2_+_36086008 2.208 Ptgs1
prostaglandin-endoperoxide synthase 1
chr3_+_142283605 2.190 NM_010260
Gbp2
guanylate binding protein 2
chr19_-_39723518 2.187 NM_001024719
Cyp2c67
cytochrome P450, family 2, subfamily c, polypeptide 67
chr4_+_64785207 2.167 NM_021362
Pappa
pregnancy-associated plasma protein A
chr7_-_20753725 2.147 NM_001166723
NM_001166749
Vmn1r94
Vmn1r142
vomeronasal 1 receptor 94
vomeronasal 1 receptor 142
chr19_+_20676453 2.104 NM_013467
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr4_+_97444450 2.078 Nfia
nuclear factor I/A
chr10_+_97110043 2.071 Epyc
epiphycan
chr14_+_124059330 2.069 NM_145467
Itgbl1
integrin, beta-like 1
chr2_+_110561733 2.060 NM_172979
Muc15
mucin 15
chr7_+_107307748 2.039 NM_026010
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr5_+_88354611 2.036 NM_007786
Csn3
casein kappa

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.07 9.66e-06 GO:0009888 tissue development
1.66 1.15e-04 GO:0048513 organ development
1.48 4.48e-04 GO:0048856 anatomical structure development
3.02 6.64e-04 GO:0048732 gland development
1.51 8.02e-04 GO:0048731 system development
1.49 2.05e-03 GO:0048519 negative regulation of biological process
1.67 2.64e-03 GO:0009653 anatomical structure morphogenesis
2.71 3.70e-03 GO:0061061 muscle structure development
1.41 6.03e-03 GO:0007275 multicellular organismal development
2.12 6.31e-03 GO:0072358 cardiovascular system development
2.12 6.31e-03 GO:0072359 circulatory system development
1.45 6.64e-03 GO:0048522 positive regulation of cellular process
1.81 6.81e-03 GO:0042127 regulation of cell proliferation
1.42 8.76e-03 GO:0048518 positive regulation of biological process
6.65 1.04e-02 GO:0051897 positive regulation of protein kinase B signaling cascade
1.54 1.07e-02 GO:0065008 regulation of biological quality
1.97 1.32e-02 GO:0009887 organ morphogenesis
1.73 1.40e-02 GO:0050793 regulation of developmental process
1.37 1.84e-02 GO:0032502 developmental process
5.54 1.85e-02 GO:0051149 positive regulation of muscle cell differentiation
1.83 2.41e-02 GO:0048584 positive regulation of response to stimulus
1.46 2.88e-02 GO:0048523 negative regulation of cellular process
3.07 2.90e-02 GO:0042692 muscle cell differentiation
1.77 2.90e-02 GO:2000026 regulation of multicellular organismal development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.90 3.95e-05 GO:0044421 extracellular region part
1.55 7.88e-04 GO:0005576 extracellular region
1.89 1.85e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.93 3.49e-03 GO:0043565 sequence-specific DNA binding
1.75 5.26e-03 GO:0030528 transcription regulator activity
1.83 5.29e-03 GO:0001071 nucleic acid binding transcription factor activity
1.83 5.29e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
10.16 3.27e-02 GO:0005159 insulin-like growth factor receptor binding