Motif ID: MSX1,2.p2

Z-value: 0.489


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
Msx1 17701 homeobox, msh-like 1
Msx2 17702 homeobox, msh-like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx1chr5_-_382156070.046.2e-01Click!
Msx2chr13_-_535681110.036.7e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_44493726 5.874 NM_001033621
Myot
myotilin
chr1_+_45401303 5.729 Col3a1
collagen, type III, alpha 1
chr5_-_44485951 5.667 NM_001163578
NM_001163581
NM_001163582
NM_001163583
NM_001163584
NM_001163585
Prom1





prominin 1





chr1_+_51345952 4.729 NM_138741
Sdpr
serum deprivation response
chr5_-_51848420 4.221 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr1_+_45390415 3.835 Col3a1
collagen, type III, alpha 1
chr8_+_96561135 3.829 Ogfod1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr1_+_45401659 3.656 Col3a1
collagen, type III, alpha 1
chr1_-_92740348 3.572 Col6a3
collagen, type VI, alpha 3
chr14_-_37911383 3.468 NM_130878
Cdhr1
cadherin-related family member 1
chr8_+_96561097 3.307 NM_001093757
NM_177767
Ogfod1

2-oxoglutarate and iron-dependent oxygenase domain containing 1

chr8_+_96561162 3.229 Ogfod1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr3_+_17695743 3.179 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr7_+_31337558 3.096 Hspb6
heat shock protein, alpha-crystallin-related, B6
chr1_+_51346086 2.950 Sdpr
serum deprivation response
chr1_+_19198994 2.728 NM_009334
Tcfap2b
transcription factor AP-2 beta
chr8_+_96561180 2.691 Ogfod1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr4_+_135354137 2.654 Myom3
myomesin family, member 3
chr13_-_62959751 2.427 Fbp2
fructose bisphosphatase 2
chr7_+_134356373 2.418 Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
chr8_-_96560811 2.281 NM_026623
Nudt21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr17_-_72102224 2.121 NM_146082
BC027072
cDNA sequence BC027072
chr1_-_166368439 2.039 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_+_49754460 2.026 NM_177052
Kif6
kinesin family member 6
chr13_-_62959656 2.009 NM_007994
Fbp2
fructose bisphosphatase 2
chr9_+_46721685 1.810 2900052N01Rik
RIKEN cDNA 2900052N01 gene
chr1_+_51346108 1.776 Sdpr
serum deprivation response
chr19_+_56798916 1.571 Adrb1
adrenergic receptor, beta 1
chr3_-_91887051 1.547 NM_008508
Lor
loricrin
chr7_+_138175581 1.455 NM_007769
Dmbt1
deleted in malignant brain tumors 1
chr2_+_25264823 1.438


chrX_+_130385546 1.431 NM_022322
Tnmd
tenomodulin
chr14_-_52530382 1.415 Ndrg2
N-myc downstream regulated gene 2
chr2_-_77357674 1.374 NM_001113400
Zfp385b
zinc finger protein 385B
chr9_-_45743950 1.332 Tagln
transgelin
chr15_+_58770843 1.297 Ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr1_-_137155012 1.289 NM_001163131
NM_007921
Elf3

E74-like factor 3

chr14_+_119187092 1.279 NM_001160096
NM_001160097
NM_001160098
NM_023878
Cldn10



claudin 10



chr10_-_61693914 1.267 Tspan15
tetraspanin 15
chrX_+_130385690 1.247 Tnmd
tenomodulin
chr12_-_77896481 1.225 Gpx2
glutathione peroxidase 2
chr6_+_125271356 1.182 NM_011324
Scnn1a
sodium channel, nonvoltage-gated 1 alpha
chr8_-_49928495 1.172 2900073C17Rik
RIKEN cDNA 2900073C17 gene
chr11_+_70470701 1.145 NM_001136062
Eno3
enolase 3, beta muscle
chr11_-_20731016 1.134 NM_173752
1110067D22Rik
RIKEN cDNA 1110067D22 gene
chr17_-_37727295 1.065 NM_146287
Olfr114
olfactory receptor 114
chr6_+_112223751 1.064 NM_144799
Lmcd1
LIM and cysteine-rich domains 1
chrX_+_136335346 1.054 NM_016675
Cldn2
claudin 2
chr9_-_103125934 1.047 Trf
transferrin
chrX_+_21292025 1.023 NM_020049
Slc6a14
solute carrier family 6 (neurotransmitter transporter), member 14
chr8_-_37631772 1.007 Dlc1
deleted in liver cancer 1
chr1_+_159436875 0.989 NM_033354
Sec16b
SEC16 homolog B (S. cerevisiae)
chr13_-_21384553 0.975 NM_010343
Gpx5
glutathione peroxidase 5
chrX_-_92361778 0.975 NM_001033329
Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
chr11_+_61022240 0.968 NM_001112725
NM_007436
Aldh3a1

aldehyde dehydrogenase family 3, subfamily A1

chr4_-_106979732 0.945 NM_007860
Dio1
deiodinase, iodothyronine, type I
chr19_+_25746900 0.938 NM_145831
Dmrt2
doublesex and mab-3 related transcription factor 2
chr2_-_62411970 0.929 NM_007986
Fap
fibroblast activation protein
chr12_-_77896410 0.915 Gpx2
glutathione peroxidase 2
chr6_+_30400873 0.892


chrX_-_92361694 0.887 Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
chr6_-_57485419 0.887 NM_175523
Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr9_-_45744036 0.876 NM_011526
Tagln
transgelin
chr3_+_97432797 0.854 Fmo5
flavin containing monooxygenase 5
chr9_+_5345475 0.841 NM_009808
Casp12
caspase 12
chr11_+_60351159 0.826 NM_172943
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chrX_+_160577312 0.817 Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr8_-_73919683 0.780 NM_181418
Ushbp1
Usher syndrome 1C binding protein 1
chr11_+_112643501 0.723 NM_011448
Sox9
SRY-box containing gene 9
chr7_-_127345462 0.687 NM_016669
Crym
crystallin, mu
chrX_-_159402493 0.687 NM_009789
S100g
S100 calcium binding protein G
chr13_+_9171776 0.676 Larp4b
La ribonucleoprotein domain family, member 4B
chr3_+_159502646 0.674 NM_026582
Wls
wntless homolog (Drosophila)
chr16_+_43247396 0.668 NM_019778
NM_181058
Zbtb20

zinc finger and BTB domain containing 20

chr6_-_58974400 0.659 NM_153574
Fam13a
family with sequence similarity 13, member A
chr14_-_69151731 0.656 NM_007402
Adam7
a disintegrin and metallopeptidase domain 7
chr9_+_46036703 0.650 NM_009692
Apoa1
apolipoprotein A-I
chr14_+_66963139 0.639 NM_019675
Stmn4
stathmin-like 4
chr1_-_42749940 0.637 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr14_+_55050437 0.635 NM_008608
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr10_+_61155793 0.631


chr6_+_58783693 0.628 NM_028705
Herc3
hect domain and RLD 3
chr11_-_73138102 0.621 NM_023113
Aspa
aspartoacylase
chr5_+_130263548 0.619 Gbas
glioblastoma amplified sequence
chr16_+_14705932 0.611 NM_011415
Snai2
snail homolog 2 (Drosophila)
chr12_-_77896363 0.588 Gpx2
glutathione peroxidase 2
chr19_-_34316029 0.587 Acta2
actin, alpha 2, smooth muscle, aorta
chr10_-_6606128 0.586 NM_001159942
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr8_+_72696276 0.571 NM_145597
Tmem161a
transmembrane protein 161A
chr8_-_114400574 0.570 NM_025781
Tmem170
transmembrane protein 170
chr16_-_38800293 0.563 NM_178924
Upk1b
uroplakin 1B
chr10_+_97110043 0.557 Epyc
epiphycan
chr11_-_70501430 0.546 Camta2
calmodulin binding transcription activator 2
chr5_-_84846256 0.535 Epha5
Eph receptor A5
chr5_-_84846348 0.532 NM_007937
Epha5
Eph receptor A5
chrX_+_160577257 0.530 NM_001130513
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_-_27316628 0.529 Fndc3b
fibronectin type III domain containing 3B
chr8_+_106625524 0.522 NM_009868
Cdh5
cadherin 5
chr8_-_109589522 0.520 NM_025458
Tmed6
transmembrane emp24 protein transport domain containing 6
chr17_-_74242984 0.512 Xdh
xanthine dehydrogenase
chr1_-_155698278 0.505 NM_178243
5830403L16Rik
RIKEN cDNA 5830403L16 gene
chr7_+_148646992 0.494 NM_001025103
Efcab4a
EF-hand calcium binding domain 4A
chr9_+_46036788 0.493 Apoa1
apolipoprotein A-I
chr14_+_119380708 0.487


chr1_-_94076857 0.484 Hdac4
histone deacetylase 4
chrX_+_9829439 0.479 NM_008769
Otc
ornithine transcarbamylase
chrX_-_159402465 0.464 S100g
S100 calcium binding protein G
chr7_-_16465217 0.457 NM_007770
Crx
cone-rod homeobox containing gene
chr3_+_159262144 0.453 NM_029987
Rpe65
retinal pigment epithelium 65
chr4_-_151692589 0.447 NM_001033489
Rnf207
ring finger protein 207
chr11_+_110829346 0.443 NM_010604
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr3_-_29911982 0.443 Mecom
MDS1 and EVI1 complex locus
chr6_+_97879810 0.430 NM_001178049
Mitf
microphthalmia-associated transcription factor
chr18_-_44821919 0.421 NM_001085374
Mcc
mutated in colorectal cancers
chr14_+_118559355 0.412 Gpr180
G protein-coupled receptor 180
chr15_-_98780503 0.411 Tuba1a
tubulin, alpha 1A
chr18_-_38443954 0.408 NM_017378
Pcdh12
protocadherin 12
chr12_-_104480335 0.403 NM_133364
Prima1
proline rich membrane anchor 1
chr16_-_29541568 0.400 NM_001164612
NM_172613
Atp13a4

ATPase type 13A4

chr14_+_37881214 0.398 NM_173418
Lrit2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr18_+_37602153 0.387 NM_053138
Pcdhb13
protocadherin beta 13
chr12_-_77896534 0.368 NM_030677
Gpx2
glutathione peroxidase 2
chr10_-_24919916 0.361 Akap7
A kinase (PRKA) anchor protein 7
chr3_+_82811802 0.353 NM_133862
Fgg
fibrinogen gamma chain
chr18_-_25637786 0.351 Celf4
CUGBP, Elav-like family member 4
chr13_-_100785524 0.346 Mccc2
methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
chr3_-_57098670 0.338 Tm4sf1
transmembrane 4 superfamily member 1
chr3_+_97432773 0.310 Fmo5
flavin containing monooxygenase 5
chr9_+_8899832 0.301 NM_008829
Pgr
progesterone receptor
chr9_-_55983967 0.295 Tspan3
tetraspanin 3
chr18_-_61874531 0.292 Grpel2
GrpE-like 2, mitochondrial
chr14_+_55050530 0.278 Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr2_+_74536030 0.278 Hoxd9
homeobox D9
chrX_-_141884479 0.270 Amot
angiomotin
chr18_-_35374531 0.251 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chrM_+_12383 0.246


chr4_+_57907600 0.243 Akap2
A kinase (PRKA) anchor protein 2
chr9_-_29770699 0.237 NM_172290
Ntm
neurotrimin
chrX_-_98254969 0.227 NM_001167997
NM_031384
Tex11

testis expressed gene 11

chr2_+_97306600 0.227


chr13_+_21404071 0.220 NM_145451
Gpx6
glutathione peroxidase 6
chr18_+_37828606 0.212 NM_033585
Pcdhga2
protocadherin gamma subfamily A, 2
chr13_+_45485106 0.203 NM_153789
NM_181043
Mylip

myosin regulatory light chain interacting protein

chr4_-_62815137 0.197 NM_007443
Ambp
alpha 1 microglobulin/bikunin
chr8_+_107872157 0.197 NM_001081332
Slc9a5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
chr10_-_88720534 0.196 NM_178773
Ano4
anoctamin 4
chr10_-_53638995 0.190 Man1a
mannosidase 1, alpha
chr4_+_139178802 0.187 NM_175438
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
chr11_-_76592473 0.184 Cpd
carboxypeptidase D
chr7_-_110926856 0.181 NM_013620
Olfr68
olfactory receptor 68
chr3_+_136566015 0.178 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr19_-_7785715 0.177 NM_144785
Slc22a19
solute carrier family 22 (organic anion transporter), member 19
chr2_-_155127037 0.176 Pigu
phosphatidylinositol glycan anchor biosynthesis, class U
chr1_-_20608010 0.171 NM_153179
Pkhd1
polycystic kidney and hepatic disease 1
chr16_-_93930061 0.171 NM_001165926
Cldn14
claudin 14
chr3_+_19857053 0.162 NM_001042611
NM_007752
Cp

ceruloplasmin

chr18_+_37637421 0.159 NM_053141
Pcdhb16
protocadherin beta 16
chr9_+_123060076 0.150 Clec3b
C-type lectin domain family 3, member b
chr3_+_93272675 0.148 NM_027762
Tchhl1
trichohyalin-like 1
chr8_-_5105158 0.147 NM_011388
Slc10a2
solute carrier family 10, member 2
chr5_-_17341713 0.142 NM_001159555
NM_007643
Cd36

CD36 antigen

chr10_+_127335573 0.141 NM_027301
Sdr9c7
4short chain dehydrogenase/reductase family 9C, member 7
chr3_-_90499611 0.138 NM_009114
S100a9
S100 calcium binding protein A9 (calgranulin B)
chr4_+_48197852 0.138 Stx17
syntaxin 17
chr4_+_139209452 0.135 NM_031873
Tas1r2
taste receptor, type 1, member 2
chr15_+_10288309 0.133 NM_001031851
Agxt2
alanine-glyoxylate aminotransferase 2
chr14_+_120830603 0.129 Mbnl2
muscleblind-like 2
chr4_-_151510433 0.128 NM_207688
NM_207689
NM_207690
NM_207691
Espn



espin



chr19_+_8876985 0.123 NM_133759
NM_001098237
Zbtb3

zinc finger and BTB domain containing 3

chr2_-_132641694 0.122 NM_175113
Trmt6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr11_+_16808929 0.120 Egfr
epidermal growth factor receptor
chr6_-_55631039 0.120 Neurod6
neurogenic differentiation 6
chr7_+_21947203 0.119 NM_001166707
Vmn1r123
vomeronasal 1 receptor 123
chr4_-_129301106 0.119 NM_025455
Ccdc28b
coiled coil domain containing 28B
chr6_-_55631085 0.116 Neurod6
neurogenic differentiation 6
chr10_+_32803288 0.113 NM_029726
Trdn
triadin
chr16_+_22951183 0.100 Hrg
histidine-rich glycoprotein
chr2_-_164063997 0.094 NM_017390
Svs2
seminal vesicle secretory protein 2
chr9_+_53619341 0.091 NM_028060
Slc35f2
solute carrier family 35, member F2
chr3_-_32981940 0.085 NM_021483
Pex5l
peroxisomal biogenesis factor 5-like
chr9_+_69855789 0.081 Bnip2
BCL2/adenovirus E1B interacting protein 2
chr18_+_37925619 0.081 Pcdhga12
protocadherin gamma subfamily A, 12
chr11_-_30371807 0.079 NM_001100394
4930505A04Rik
RIKEN cDNA 4930505A04 gene
chr11_-_119960005 0.078 NM_183137
2410002I01Rik
RIKEN cDNA 2410002I01 gene
chr19_-_59420234 0.078 NM_001033222
Pdzd8
PDZ domain containing 8
chr2_-_10052196 0.070 NM_010582
Itih2
inter-alpha trypsin inhibitor, heavy chain 2
chr5_-_69933835 0.063 NM_023784
Yipf7
Yip1 domain family, member 7
chr2_+_119000244 0.062 NM_001039223
Gm14137
predicted gene 14137
chr9_-_46128068 0.060 NM_183104
4931429L15Rik
RIKEN cDNA 4931429L15 gene
chr11_-_120238194 0.058 2310003H01Rik
RIKEN cDNA 2310003H01 gene
chr2_-_34916915 0.056 NM_010406
Hc
hemolytic complement
chr5_+_88314719 0.056 NM_027128
Odam
odontogenic, ameloblast asssociated
chr5_-_147396814 0.055 NM_001010941
Gpr12
G-protein coupled receptor 12
chr1_-_170362244 0.053 Pbx1
pre B-cell leukemia transcription factor 1
chr10_+_90038471 0.052 NM_001177397
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr16_-_91069378 0.052 NM_001163695
NM_028905
4932438H23Rik

RIKEN cDNA 4932438H23 gene

chr18_+_50115628 0.047 Dmxl1
Dmx-like 1
chr8_-_70498472 0.045 NM_177698
Psd3
pleckstrin and Sec7 domain containing 3
chr15_+_18750083 0.045 NM_009865
Cdh10
cadherin 10
chr9_+_121643763 0.042 Nktr
natural killer tumor recognition sequence

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.90 1.60e-02 GO:0048856 anatomical structure development
2.90 2.61e-02 GO:0055114 oxidation-reduction process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.53 1.46e-04 GO:0016324 apical plasma membrane
1.83 1.78e-04 GO:0071944 cell periphery
1.84 2.08e-04 GO:0005886 plasma membrane
5.36 3.77e-04 GO:0045177 apical part of cell
2.26 4.96e-04 GO:0044459 plasma membrane part

Nothing significant found in function category.