Motif ID: MYBL2.p2

Z-value: 1.142


Transcription factors associated with MYBL2.p2:

Gene SymbolEntrez IDGene Name
Mybl2 17865 myeloblastosis oncogene-like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl2chr2_+_162880370-0.401.4e-08Click!


Activity profile for motif MYBL2.p2.

activity profile for motif MYBL2.p2


Sorted Z-values histogram for motif MYBL2.p2

Sorted Z-values for motif MYBL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYBL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_104543106 21.059 NM_010097
Sparcl1
SPARC-like 1
chr13_+_49704471 18.717 Ogn
osteoglycin
chr16_+_35002066 13.966 Mylk
myosin, light polypeptide kinase
chr11_+_93905443 12.478 Spag9
sperm associated antigen 9
chr6_+_70676428 12.473


chr13_+_83803830 11.751 Mef2c
myocyte enhancer factor 2C
chr11_+_87607531 11.364 Mpo
myeloperoxidase
chr16_+_96422243 11.089 Sh3bgr
SH3-binding domain glutamic acid-rich protein
chr11_+_87607285 10.710 NM_010824
Mpo
myeloperoxidase
chr11_+_93905557 10.568 Spag9
sperm associated antigen 9
chr4_-_60594496 10.201 Mup1
major urinary protein 1
chr4_-_60889249 9.959 NM_001134674
Mup13
Mup19
Mup1
major urinary protein 13
major urinary protein 19
major urinary protein 1
chr4_-_60594469 9.716 Mup1
major urinary protein 1
chrX_+_54032858 9.573 NM_001077362
Fhl1
four and a half LIM domains 1
chr2_+_103798150 9.494 NM_001142337
Lmo2
LIM domain only 2
chr4_+_138012860 9.261 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr16_+_96422076 9.201 NM_015825
Sh3bgr
SH3-binding domain glutamic acid-rich protein
chr16_+_35001358 8.902 Mylk
myosin, light polypeptide kinase
chr6_-_60779848 8.699 NM_009221
Snca
synuclein, alpha
chrX_+_54032914 8.674 Fhl1
four and a half LIM domains 1
chr16_+_34995000 8.438 Mylk
myosin, light polypeptide kinase
chr6_+_70676803 8.390


chr11_+_94811409 8.189 Col1a1
collagen, type I, alpha 1
chr11_+_93905501 7.863 NM_001025428
NM_001025429
NM_001025430
Spag9


sperm associated antigen 9


chr2_-_6466116 7.669 Celf2
CUGBP, Elav-like family member 2
chr18_-_60783889 7.563 Synpo
synaptopodin
chr1_-_82232392 7.481 Irs1
insulin receptor substrate 1
chr3_+_95303177 7.217 NM_007802
Ctsk
cathepsin K
chrX_+_54043764 7.130 Fhl1
four and a half LIM domains 1
chr6_+_4471231 7.103 Col1a2
collagen, type I, alpha 2
chr9_+_40590943 6.791 9030425E11Rik
RIKEN cDNA 9030425E11 gene
chr19_+_26822892 6.697 NM_026003
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_+_97535490 6.524 NM_001040087
NM_001040088
Sytl2

synaptotagmin-like 2

chrX_+_133357268 6.483 NM_011123
Plp1
proteolipid protein (myelin) 1
chr16_+_96422285 6.292 Sh3bgr
SH3-binding domain glutamic acid-rich protein
chr2_-_164182009 6.267 Slpi
secretory leukocyte peptidase inhibitor
chr6_-_90611092 6.168 Iqsec1
IQ motif and Sec7 domain 1
chr7_+_97535516 5.945 Sytl2
synaptotagmin-like 2
chr1_-_72906185 5.917 Igfbp5
insulin-like growth factor binding protein 5
chr1_-_166368439 5.648 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr4_-_60675161 5.546 NM_001164526
NM_001134644
NM_001045550
NM_008647
Mup10
Mup11
LOC100048885
Mup19
Mup1
Mup2

major urinary protein 10
major urinary protein 11
major urinary protein LOC100048885
major urinary protein 19
major urinary protein 1
major urinary protein 2

chr1_-_140071818 5.535 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr16_+_56477956 5.453 NM_001014399
NM_001014422
NM_001014423
NM_001014424
NM_178790
Abi3bp




ABI gene family, member 3 (NESH) binding protein




chr10_+_4978047 5.395 Syne1
synaptic nuclear envelope 1
chr1_+_135934035 5.378 NM_021355
Fmod
fibromodulin
chr3_-_126646303 5.321 NM_001034168
Ank2
ankyrin 2, brain
chr2_+_69508174 5.075 NM_001081087
Kbtbd10
kelch repeat and BTB (POZ) domain containing 10
chr9_+_50561121 5.056 Cryab
crystallin, alpha B
chr14_-_104213981 5.025


chr9_+_50561092 5.014 Cryab
crystallin, alpha B
chr4_+_102260162 4.963 NM_001177982
Pde4b
phosphodiesterase 4B, cAMP specific
chr18_-_70301202 4.916 NM_001082553
Rab27b
RAB27b, member RAS oncogene family
chr1_-_45560001 4.795 NM_007737
Col5a2
collagen, type V, alpha 2
chr4_-_136891931 4.731 Cdc42
cell division cycle 42 homolog (S. cerevisiae)
chr9_+_50560862 4.664 NM_009964
Cryab
crystallin, alpha B
chr19_+_54003803 4.637 Pdcd4
programmed cell death 4
chr11_-_5703752 4.603 NM_018870
Pgam2
phosphoglycerate mutase 2
chr1_-_66981900 4.575 NM_001113387
Myl1
myosin, light polypeptide 1
chrX_+_133371611 4.466 Plp1
proteolipid protein (myelin) 1
chr1_-_172857670 4.372 NM_001160215
NM_145141
Fcrla

Fc receptor-like A

chr11_-_5703677 4.299 Pgam2
phosphoglycerate mutase 2
chr19_+_23215725 4.269 Klf9
Kruppel-like factor 9
chr3_-_122737855 4.202 NM_021503
Myoz2
myozenin 2
chrX_-_54646073 4.136 NM_001166623
NM_011252
Rbmx

RNA binding motif protein, X chromosome

chr18_+_61085283 3.966 NM_177407
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr2_+_32484995 3.965 NM_021515
Ak1
adenylate kinase 1
chr4_-_60594959 3.944 NM_001122647
Mup10
LOC100048884
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 1
chr14_+_84933363 3.831 Pcdh17
protocadherin 17
chr19_+_23241546 3.823 Klf9
Kruppel-like factor 9
chr9_+_50561381 3.807 Cryab
crystallin, alpha B
chr4_+_102262447 3.764 NM_001177981
Pde4b
phosphodiesterase 4B, cAMP specific
chr17_+_8437922 3.749 NM_001190338
Ccr6
chemokine (C-C motif) receptor 6
chr1_-_140071630 3.717 Ptprc
protein tyrosine phosphatase, receptor type, C
chr17_+_70871444 3.601 NM_001128180
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_-_4752710 3.596 NM_026793
Myct1
myc target 1
chr18_+_61085303 3.391 Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr2_+_16277963 3.372 Plxdc2
plexin domain containing 2
chr2_-_122420914 3.363 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr12_-_119474010 3.338 Sp4
trans-acting transcription factor 4
chr5_-_23012407 3.296 Srpk2
serine/arginine-rich protein specific kinase 2
chr5_-_24606229 3.261 Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr2_-_23904343 3.220 Hnmt
histamine N-methyltransferase
chr6_-_87483228 3.144 NM_001037727
Arhgap25
Rho GTPase activating protein 25
chr11_+_98667577 3.116 Msl1
male-specific lethal 1 homolog (Drosophila)
chr4_-_61179982 3.024 Mup1
major urinary protein 1
chr2_-_164182242 3.018 NM_011414
Slpi
secretory leukocyte peptidase inhibitor
chr11_+_62633754 2.935 NM_053169
Trim16
tripartite motif-containing 16
chr14_-_44501032 2.894 NM_053112
Ear10
eosinophil-associated, ribonuclease A family, member 10
chr9_+_50561315 2.887 Cryab
crystallin, alpha B
chr4_-_60736086 2.886 Mup10
Mup1
major urinary protein 10
major urinary protein 1
chr19_-_47766512 2.840 NM_007732
Col17a1
collagen, type XVII, alpha 1
chr8_-_80248234 2.828 Ednra
endothelin receptor type A
chr5_+_43906796 2.803 NM_001135172
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr5_+_43907004 2.758 C1qtnf7
C1q and tumor necrosis factor related protein 7
chr17_+_71368860 2.728 NM_001083934
NM_010867
Myom1

myomesin 1

chr5_-_122906470 2.683 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr19_+_23215704 2.671 NM_010638
Klf9
Kruppel-like factor 9
chr2_+_121121189 2.656 NM_001173506
Mtap1a
microtubule-associated protein 1 A
chr6_-_129572590 2.629 NM_033078
Klrk1
killer cell lectin-like receptor subfamily K, member 1
chr17_-_34424623 2.570 NM_010378
H2-Aa
histocompatibility 2, class II antigen A, alpha
chr5_-_144266956 2.507


chr9_-_21820860 2.486 Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
chr3_-_152645206 2.471 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr9_-_112090150 2.449 NM_033264
NM_001177615
NM_001177620
NM_028755
Arpp21



cyclic AMP-regulated phosphoprotein, 21



chr4_-_41261743 2.445 Dcaf12
DDB1 and CUL4 associated factor 12
chr7_+_25421551 2.441 Lypd3
Ly6/Plaur domain containing 3
chr6_+_88674821 2.427 Mgll
monoglyceride lipase
chr4_-_41261815 2.413 Dcaf12
DDB1 and CUL4 associated factor 12
chr14_+_102239673 2.393 Lmo7
LIM domain only 7
chr16_+_78931190 2.350 NM_139134
Chodl
chondrolectin
chrX_+_130829929 2.332 Tmem35
transmembrane protein 35
chr11_-_6420931 2.329 NM_178440
Myo1g
myosin IG
chr14_+_51748742 2.323 NM_030098
Rnase6
ribonuclease, RNase A family, 6
chr19_+_12040311 2.314 NM_001033174
Osbp
oxysterol binding protein
chr2_+_125860507 2.305 Fgf7
fibroblast growth factor 7
chr11_-_30000031 2.300 Spnb2
spectrin beta 2
chr6_-_119146426 2.297 NM_009781
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr14_+_124059330 2.273 NM_145467
Itgbl1
integrin, beta-like 1
chr1_+_89967340 2.236 NM_201644
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr6_-_54543167 2.235 Fkbp14
FK506 binding protein 14
chr4_+_102242664 2.219 NM_001177980
Pde4b
phosphodiesterase 4B, cAMP specific
chr11_-_21222127 2.218 Ugp2
UDP-glucose pyrophosphorylase 2
chr5_-_24501570 2.216 Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr4_+_94406190 2.209 Tek
endothelial-specific receptor tyrosine kinase
chr8_+_72758454 2.208 Sugp2
SURP and G patch domain containing 2
chr1_-_194681914 2.204 NM_198247
Sertad4
SERTA domain containing 4
chr7_-_110962416 2.197 NM_008220
NM_016956
Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr2_-_30141815 2.164 Dolk
dolichol kinase
chr11_-_6420904 2.160 Myo1g
myosin IG
chr9_-_70452528 2.145 Fam63b
family with sequence similarity 63, member B
chr8_+_46593141 2.096 NM_172752
Sorbs2
sorbin and SH3 domain containing 2
chr5_+_104631633 2.090 NM_016779
Dmp1
dentin matrix protein 1
chr9_-_16182674 2.086 NM_001080814
Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr7_+_25421586 2.054 NM_133743
Lypd3
Ly6/Plaur domain containing 3
chr14_+_52473672 2.050 NM_017385
Ear7
eosinophil-associated, ribonuclease A family, member 7
chr16_+_33794452 2.034 Muc13
mucin 13, epithelial transmembrane
chr16_+_45093784 2.022 Ccdc80
coiled-coil domain containing 80
chr6_-_54543121 2.014 NM_153573
Fkbp14
FK506 binding protein 14
chr16_+_34994935 2.005 Mylk
myosin, light polypeptide kinase
chr8_+_72758086 1.995 NM_001168290
NM_172755
Sugp2

SURP and G patch domain containing 2

chr2_+_14310024 1.986 NM_001012305
Slc39a12
solute carrier family 39 (zinc transporter), member 12
chrX_+_130829763 1.984 NM_026239
Tmem35
transmembrane protein 35
chr6_+_68375560 1.981 Igkv16-104
immunoglobulin kappa variable 16-104
chr9_+_14080744 1.959 NM_030261
Sesn3
sestrin 3
chr9_+_75623153 1.936 NM_007555
Bmp5
bone morphogenetic protein 5
chr16_+_43619057 1.935 Zbtb20
zinc finger and BTB domain containing 20
chr9_-_79566271 1.931 NM_007730
Col12a1
collagen, type XII, alpha 1
chr1_+_34356614 1.930 Dst
dystonin
chr10_-_41905549 1.930 Foxo3
forkhead box O3
chr3_-_146433544 1.892 NM_001164199
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr3_-_92289795 1.851 NM_009264
Sprr1a
small proline-rich protein 1A
chr8_+_56040553 1.848 Gpm6a
glycoprotein m6a
chr9_+_44448105 1.842 Ddx6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr1_+_90003410 1.840 Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr5_+_111846284 1.835 Mn1
meningioma 1
chr6_+_124254668 1.831 NM_001170395
NM_053094
Cd163

CD163 antigen

chrX_+_146981959 1.812 NM_001102446
NM_009653
Alas2

aminolevulinic acid synthase 2, erythroid

chr3_+_136566015 1.798 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr19_-_21547035 1.792 Gda
guanine deaminase
chr12_+_105452740 1.745 NM_009251
NM_001168294
NM_001168295
NM_001033335
Serpina3g
Serpina3f


Serpina3h
serine (or cysteine) peptidase inhibitor, clade A, member 3G
serine (or cysteine) peptidase inhibitor, clade A, member 3F


serine (or cysteine) peptidase inhibitor, clade A, member 3H
chr11_+_115168476 1.740 NM_172801
Otop2
otopetrin 2
chr18_+_69753146 1.737 Tcf4
transcription factor 4
chr2_+_55288297 1.737 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr3_-_92460819 1.732 NM_026822
Lce1b
late cornified envelope 1B
chr6_+_96063137 1.717 NM_182808
Fam19a1
family with sequence similarity 19, member A1
chr19_-_21547072 1.713 NM_010266
Gda
guanine deaminase
chr17_+_75864877 1.711 NM_207246
Rasgrp3
RAS, guanyl releasing protein 3
chr8_-_72425538 1.707 Ndufa13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr19_-_23522811 1.676 NM_174857
Mamdc2
MAM domain containing 2
chr16_+_33794122 1.674 NM_010739
Muc13
mucin 13, epithelial transmembrane
chr12_+_53800369 1.674 NM_198111
Akap6
A kinase (PRKA) anchor protein 6
chr11_-_118163704 1.669 Timp2
tissue inhibitor of metalloproteinase 2
chr12_+_72149332 1.648 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr14_-_122138082 1.604 NM_001128307
NM_001128308
Dock9

dedicator of cytokinesis 9

chr15_-_78034565 1.598 NM_013645
Pvalb
parvalbumin
chr11_-_30839546 1.596 Erlec1
endoplasmic reticulum lectin 1
chr18_-_39078304 1.595 NM_010197
Fgf1
fibroblast growth factor 1
chr16_-_14291427 1.589 NM_001161775
NM_013607
Myh11

myosin, heavy polypeptide 11, smooth muscle

chr4_-_41261874 1.571 Dcaf12
DDB1 and CUL4 associated factor 12
chr3_-_152645143 1.570 NM_012028
St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr8_-_37631532 1.559 Dlc1
deleted in liver cancer 1
chr17_+_35373506 1.556 NM_023179
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr2_+_125860377 1.543 NM_008008
Fgf7
fibroblast growth factor 7
chr11_+_94812919 1.539 Col1a1
collagen, type I, alpha 1
chr14_+_45607785 1.538 NM_008964
Ptger2
prostaglandin E receptor 2 (subtype EP2)
chr3_+_7366586 1.536 NM_008862
Pkia
protein kinase inhibitor, alpha
chr1_-_45460310 1.534 Col5a2
collagen, type V, alpha 2
chr15_-_91022198 1.527 NM_011994
Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr5_+_65522325 1.512 NM_175174
Klhl5
kelch-like 5 (Drosophila)
chr13_-_36826104 1.505 Nrn1
neuritin 1
chrX_-_73088288 1.501 NM_001166454
Pls3
plastin 3 (T-isoform)
chr10_-_118293979 1.492 Dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr5_+_90889937 1.486 Alb
albumin
chr19_-_46401618 1.485 NM_028627
Psd
pleckstrin and Sec7 domain containing
chr4_-_137869546 1.479 Pink1
PTEN induced putative kinase 1
chr8_-_42127124 1.468 Mtus1
mitochondrial tumor suppressor 1
chr7_-_107805466 1.456 NM_001163186
NM_001163187
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr15_-_91022165 1.452 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr2_+_16277924 1.451 NM_026162
Plxdc2
plexin domain containing 2
chr7_-_148615247 1.444 NM_021316
Cend1
cell cycle exit and neuronal differentiation 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.48 4.47e-04 GO:0051494 negative regulation of cytoskeleton organization
2.32 2.63e-03 GO:0022610 biological adhesion
4.52 4.35e-03 GO:0010639 negative regulation of organelle organization
1.77 5.45e-03 GO:0051239 regulation of multicellular organismal process
2.27 5.52e-03 GO:0007155 cell adhesion
6.78 9.56e-03 GO:0031333 negative regulation of protein complex assembly
7.82 1.04e-02 GO:0032272 negative regulation of protein polymerization
1.66 3.86e-02 GO:0048583 regulation of response to stimulus
3.95 4.33e-02 GO:0010466 negative regulation of peptidase activity

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.81 1.09e-05 GO:0005576 extracellular region
3.31 2.69e-05 GO:0005578 proteinaceous extracellular matrix
2.91 3.25e-04 GO:0031012 extracellular matrix
1.44 5.57e-04 GO:0071944 cell periphery
1.44 7.89e-04 GO:0005886 plasma membrane
2.43 1.05e-03 GO:0045202 synapse
4.33 1.15e-03 GO:0044420 extracellular matrix part
1.96 1.28e-03 GO:0044421 extracellular region part
2.02 7.10e-03 GO:0005615 extracellular space
4.14 8.82e-03 GO:0044449 contractile fiber part
2.71 1.03e-02 GO:0015629 actin cytoskeleton
3.79 1.05e-02 GO:0043292 contractile fiber
4.33 1.23e-02 GO:0030017 sarcomere
3.81 1.99e-02 GO:0030016 myofibril
1.20 2.99e-02 GO:0005737 cytoplasm
1.15 3.40e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.93 3.25e-07 GO:0008092 cytoskeletal protein binding
1.43 5.15e-07 GO:0005515 protein binding
2.36 2.32e-06 GO:0030234 enzyme regulator activity
21.71 3.07e-05 GO:0004522 pancreatic ribonuclease activity
3.44 3.19e-05 GO:0004857 enzyme inhibitor activity
3.14 1.10e-04 GO:0003779 actin binding
18.09 1.29e-04 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
3.88 3.67e-04 GO:0030414 peptidase inhibitor activity
3.87 7.53e-04 GO:0004866 endopeptidase inhibitor activity
3.73 1.26e-03 GO:0061135 endopeptidase regulator activity
12.77 1.53e-03 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
3.81 1.84e-03 GO:0001871 pattern binding
3.81 1.84e-03 GO:0030247 polysaccharide binding
3.32 3.31e-03 GO:0061134 peptidase regulator activity
2.44 7.78e-03 GO:0060589 nucleoside-triphosphatase regulator activity
5.71 8.99e-03 GO:0004540 ribonuclease activity
3.73 9.17e-03 GO:0005539 glycosaminoglycan binding
4.14 1.23e-02 GO:0004867 serine-type endopeptidase inhibitor activity
2.42 1.25e-02 GO:0030695 GTPase regulator activity
1.16 1.39e-02 GO:0005488 binding
2.42 1.76e-02 GO:0030246 carbohydrate binding
6.67 2.63e-02 GO:0004521 endoribonuclease activity
4.47 2.86e-02 GO:0008017 microtubule binding
3.90 4.42e-02 GO:0008201 heparin binding