Motif ID: MZF1.p2

Z-value: 2.295


Transcription factors associated with MZF1.p2:

Gene SymbolEntrez IDGene Name
Mzf1 109889 myeloid zinc finger 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mzf1chr7_-_136398620.083.1e-01Click!


Activity profile for motif MZF1.p2.

activity profile for motif MZF1.p2


Sorted Z-values histogram for motif MZF1.p2

Sorted Z-values for motif MZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_170362298 64.374 Pbx1
pre B-cell leukemia transcription factor 1
chr3_+_156224757 46.061 NM_001039094
NM_177274
Negr1

neuronal growth regulator 1

chr1_-_82287990 45.573 NM_010570
Irs1
insulin receptor substrate 1
chr13_-_78337844 42.409 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr2_-_84615535 41.350 NM_009776
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr18_-_16967557 37.518 NM_007664
Cdh2
cadherin 2
chr7_-_112729716 36.133 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr1_-_170361985 36.017 Pbx1
pre B-cell leukemia transcription factor 1
chrX_-_132749976 35.810 NM_009052
Bex1
brain expressed gene 1
chr2_-_91772424 33.775 NM_010784
Mdk
midkine
chr1_-_170362388 33.744 NM_008783
NM_183355
Pbx1

pre B-cell leukemia transcription factor 1

chr18_-_16967100 33.519 Cdh2
cadherin 2
chr4_+_138012860 32.598 Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr4_-_82151590 30.756 Nfib
nuclear factor I/B
chr9_-_49607164 30.064 NM_001081445
NM_001113204
NM_010875
Ncam1


neural cell adhesion molecule 1


chr5_-_133019167 29.716 Auts2
autism susceptibility candidate 2
chr7_-_89079168 29.133 Hdgfrp3
hepatoma-derived growth factor, related protein 3
chr16_+_8513513 28.368 NM_001170978
NM_172961
Abat

4-aminobutyrate aminotransferase

chr6_-_124718354 28.265 Eno2
enolase 2, gamma neuronal
chr18_-_16967754 26.251 Cdh2
cadherin 2
chr7_-_25857275 26.065 NM_008168
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
chr2_-_84614976 24.444 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr7_+_31076852 23.755 Clip3
CAP-GLY domain containing linker protein 3
chr2_-_84614960 23.435 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_-_69648350 22.661 NM_198862
Nlgn2
neuroligin 2
chr7_+_133966816 21.964 NM_029978
Fam57b
family with sequence similarity 57, member B
chr2_+_70400179 21.808 NM_008077
Gad1
glutamic acid decarboxylase 1
chr9_-_91259829 21.604 Zic1
zinc finger protein of the cerebellum 1
chr3_+_95985065 21.552 NM_022030
Sv2a
synaptic vesicle glycoprotein 2 a
chr13_-_36826245 21.481 NM_153529
Nrn1
neuritin 1
chr14_-_52532988 21.352 Ndrg2
N-myc downstream regulated gene 2
chr15_-_82210591 21.241 NM_001163472
NM_019823
Cyp2d22

cytochrome P450, family 2, subfamily d, polypeptide 22

chr6_-_92431385 21.179 NM_001134460
Prickle2
prickle homolog 2 (Drosophila)
chr14_-_52533039 21.151 Ndrg2
N-myc downstream regulated gene 2
chr2_+_132607013 20.537 NM_007694
Chgb
chromogranin B
chr2_-_52532100 19.979 NM_001037099
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
chr11_+_69831951 19.623 NM_001109752
NM_007864
Dlg4

discs, large homolog 4 (Drosophila)

chr1_+_160292470 19.469 NM_007495
Astn1
astrotactin 1
chr5_-_133018212 19.306 NM_177047
Auts2
autism susceptibility candidate 2
chr11_+_89894863 19.160 Tmem100
transmembrane protein 100
chr2_+_48805027 19.092 NM_029924
Mbd5
methyl-CpG binding domain protein 5
chr16_+_35154935 18.767 Adcy5
adenylate cyclase 5
chr1_+_66515003 18.686 NM_175510
Unc80
unc-80 homolog (C. elegans)
chr11_+_54117299 18.641 NM_001033598
Acsl6
acyl-CoA synthetase long-chain family member 6
chr6_-_113841295 18.581 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr6_-_4697009 18.269 NM_001130188
NM_001130189
NM_001130190
NM_001130191
NM_011360
Sgce




sarcoglycan, epsilon




chr2_+_164793698 17.969 Slc12a5
solute carrier family 12, member 5
chr2_-_115890747 17.925 NM_001136072
NM_001159567
NM_001159568
NM_010825
Meis2



Meis homeobox 2



chr2_-_115890247 17.884 NM_001159569
NM_001159570
Meis2

Meis homeobox 2

chr6_+_91162756 17.868 NM_001081437
NM_007992
Fbln2

fibulin 2

chr7_+_31076771 17.246 NM_001081114
Clip3
CAP-GLY domain containing linker protein 3
chr11_+_54117703 17.208 NM_001033597
NM_144823
Acsl6

acyl-CoA synthetase long-chain family member 6

chr13_-_78338131 16.905 NM_010151
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr19_+_27291897 16.818 Vldlr
very low density lipoprotein receptor
chr7_+_4642529 16.816 NM_001003920
NM_001168572
Brsk1

BR serine/threonine kinase 1

chrX_+_97972559 16.745 NM_001177780
Dlg3
discs, large homolog 3 (Drosophila)
chr14_-_68743060 16.712 NM_008691
Nefm
neurofilament, medium polypeptide
chr4_-_82151004 16.695 Nfib
nuclear factor I/B
chr2_+_177876858 16.538 Phactr3
phosphatase and actin regulator 3
chr6_-_113841356 16.383 NM_001036684
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr4_-_128798939 16.333 NM_001130419
Hpca
hippocalcin
chr17_-_34875879 16.330 C4b
complement component 4B (Childo blood group)
chr6_+_45010040 16.317 NM_001004357
Cntnap2
contactin associated protein-like 2
chr2_+_25098448 16.315 NM_176834
Rnf208
ring finger protein 208
chr14_-_55735114 16.241 NM_177049
Jph4
junctophilin 4
chrX_+_132373572 16.049 NM_001163015
NM_001163016
NM_001163017
Gprasp2


G protein-coupled receptor associated sorting protein 2


chr7_-_89079335 15.777 NM_013886
Hdgfrp3
hepatoma-derived growth factor, related protein 3
chr7_+_134094045 15.777 NM_144926
Sez6l2
seizure related 6 homolog like 2
chr6_+_88775664 15.717 Mgll
monoglyceride lipase
chr4_-_68615283 15.576 Dbc1
deleted in bladder cancer 1 (human)
chr11_+_69832336 15.559 Dlg4
discs, large homolog 4 (Drosophila)
chr19_+_27292039 15.550 Vldlr
very low density lipoprotein receptor
chr4_-_82151657 15.535 Nfib
nuclear factor I/B
chr9_-_108499855 15.520 NM_028944
P4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr7_-_134164487 15.514 Prrt2
proline-rich transmembrane protein 2
chr10_-_76086045 15.450 Col6a2
collagen, type VI, alpha 2
chr13_-_36826104 15.441 Nrn1
neuritin 1
chr13_+_46597271 15.375 NM_026056
Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr11_-_30854081 15.252 NM_025745
Erlec1
endoplasmic reticulum lectin 1
chr4_-_147534144 15.236 NM_001161852
NM_173401
Fbxo44

F-box protein 44

chr14_-_55531726 15.222 NM_021551
Slc22a17
solute carrier family 22 (organic cation transporter), member 17
chr10_-_108447674 15.160 NM_009306
Syt1
synaptotagmin I
chr6_+_124959207 15.076 Zfp384
zinc finger protein 384
chr14_-_52533114 14.996 NM_001145959
NM_013864
Ndrg2

N-myc downstream regulated gene 2

chrX_-_45245608 14.867 NM_053123
Smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr1_+_42752608 14.837


chr1_+_160292665 14.727 Astn1
astrotactin 1
chr14_-_35315715 14.689 NM_009758
Bmpr1a
bone morphogenetic protein receptor, type 1A
chr10_-_76086144 14.623 NM_146007
Col6a2
collagen, type VI, alpha 2
chr10_-_80119815 14.581 NM_145361
Btbd2
BTB (POZ) domain containing 2
chr7_+_37483196 14.544 Tshz3
teashirt zinc finger family member 3
chrX_-_131745187 14.476 NM_025355
Tceal6
transcription elongation factor A (SII)-like 6
chr4_-_82150687 14.444 Nfib
nuclear factor I/B
chr1_-_125942073 14.328 NM_199021
Dpp10
dipeptidylpeptidase 10
chr12_+_110800212 14.080 Meg3
maternally expressed 3
chrX_+_133200982 14.061 Tceal3
transcription elongation factor A (SII)-like 3
chr4_-_33010429 13.931 NM_001012450
NM_080471
Ankrd6

ankyrin repeat domain 6

chr9_+_72510153 13.876 NM_010890
Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chrX_+_133200913 13.812 NM_001029978
Tceal3
transcription elongation factor A (SII)-like 3
chr18_-_33623668 13.717 NM_001109988
D0H4S114
DNA segment, human D4S114
chr15_+_98462650 13.643 NM_001044741
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr11_+_56825258 13.547 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr9_+_103014279 13.352 Rab6b
RAB6B, member RAS oncogene family
chr16_-_42340613 13.282 NM_008083
Gap43
growth associated protein 43
chr17_+_25945986 13.280 NM_001164225
Fbxl16
F-box and leucine-rich repeat protein 16
chr8_-_105308910 13.223 NM_009866
Cdh11
cadherin 11
chr11_+_78137699 13.138 NM_009657
Aldoc
aldolase C, fructose-bisphosphate
chr5_-_45190857 13.122 NM_001077398
NM_010698
Ldb2

LIM domain binding 2

chr13_+_19040215 13.098 NM_175007
Amph
amphiphysin
chr14_-_71028756 12.960 Epb4.9
erythrocyte protein band 4.9
chr11_+_98603186 12.959 NM_178060
Thra
thyroid hormone receptor alpha
chr15_+_87374667 12.881 Fam19a5
family with sequence similarity 19, member A5
chr7_-_134164627 12.861 NM_001102563
Prrt2
proline-rich transmembrane protein 2
chr8_-_87323896 12.766 Nfix
nuclear factor I/X
chr1_+_34858612 12.713 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr10_-_79379610 12.699 NM_177994
C030046I01Rik
RIKEN cDNA C030046I01 gene
chrX_+_33735898 12.593 NM_028325
Zcchc12
zinc finger, CCHC domain containing 12
chr17_+_37182910 12.575 NM_019439
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr15_-_99358024 12.547 Faim2
Fas apoptotic inhibitory molecule 2
chr7_-_134093094 12.511 NM_001039645
Asphd1
aspartate beta-hydroxylase domain containing 1
chr14_-_30534966 12.333 NM_009785
Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
chr18_-_25912171 12.325 Celf4
CUGBP, Elav-like family member 4
chr2_-_91771882 12.316 Mdk
midkine
chr2_+_38206759 12.226 NM_010710
Lhx2
LIM homeobox protein 2
chr10_+_56097078 12.204 NM_010288
Gja1
gap junction protein, alpha 1
chr9_-_91260619 12.166 NM_009573
Zic1
zinc finger protein of the cerebellum 1
chr15_-_75397243 12.135 NM_001135688
Ly6h
lymphocyte antigen 6 complex, locus H
chrX_+_100551808 12.132 NM_009767
Chic1
cysteine-rich hydrophobic domain 1
chrX_-_132738383 12.103 NM_177919
Tceal5
transcription elongation factor A (SII)-like 5
chr10_+_96942124 12.098 NM_001190451
Dcn
decorin
chr17_+_37187550 12.094 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr4_-_57003214 12.002 NM_001142965
6430704M03Rik
RIKEN cDNA 6430704M03 gene
chr7_-_25772525 11.968 Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr11_+_56825192 11.943 NM_001113325
NM_008165
Gria1

glutamate receptor, ionotropic, AMPA1 (alpha 1)

chr7_-_17200285 11.938 NM_172739
Grlf1
glucocorticoid receptor DNA binding factor 1
chr5_-_139605617 11.821 NM_008923
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_+_54960816 11.802 NM_172867
Zfp462
zinc finger protein 462
chr9_-_86775154 11.781 NM_013669
Snap91
synaptosomal-associated protein 91
chr15_-_79656745 11.772 Cbx6
chromobox homolog 6
chr10_+_90292453 11.742 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_+_4853319 11.731 NM_181595
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr2_+_177876710 11.718 Phactr3
phosphatase and actin regulator 3
chr17_+_27792587 11.612 NM_011861
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chrX_+_132528317 11.608 NM_029823
6530401D17Rik
2900062L11Rik
RIKEN cDNA 6530401D17 gene
RIKEN cDNA 2900062L11 gene
chr15_+_98465328 11.579 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr5_-_107718503 11.556 NM_011578
Tgfbr3
transforming growth factor, beta receptor III
chr4_+_41709182 11.519 NM_010549
Il11ra1
interleukin 11 receptor, alpha chain 1
chr14_-_94289847 11.510 Pcdh9
protocadherin 9
chrX_-_49518428 11.471 Gpc4
glypican 4
chr6_+_114232618 11.439 NM_178703
Slc6a1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr18_-_16966954 11.419 Cdh2
cadherin 2
chr7_-_108043203 11.349 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr4_-_68615382 11.329 NM_019967
Dbc1
deleted in bladder cancer 1 (human)
chr4_+_43644806 11.320 NM_173788
Npr2
natriuretic peptide receptor 2
chrX_-_101017152 11.308 Slc16a2
solute carrier family 16 (monocarboxylic acid transporters), member 2
chrX_+_133242520 11.303 NM_146236
Tceal1
transcription elongation factor A (SII)-like 1
chr14_-_52935887 11.300 Sall2
sal-like 2 (Drosophila)
chr16_-_20621287 11.270 NM_028420
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chrX_-_131343508 11.256 Armcx2
armadillo repeat containing, X-linked 2
chr6_-_92656148 11.217 NM_001081146
Prickle2
prickle homolog 2 (Drosophila)
chr13_+_118391270 11.123 Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
chr11_-_90252208 11.090 Hlf
hepatic leukemia factor
chr11_-_70846926 11.075 6330403K07Rik
RIKEN cDNA 6330403K07 gene
chr9_+_50560862 11.046 NM_009964
Cryab
crystallin, alpha B
chrX_+_133357268 11.027 NM_011123
Plp1
proteolipid protein (myelin) 1
chr9_-_58884114 11.014 NM_001042752
NM_008684
Neo1

neogenin

chr10_+_90292388 10.968 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_101223198 10.883 NM_001164583
Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr9_+_89804612 10.883 NM_001039655
NM_011245
Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr8_-_87296172 10.849 Nfix
nuclear factor I/X
chr10_+_4795808 10.780 NM_153399
Syne1
synaptic nuclear envelope 1
chr1_+_60466620 10.772 Abi2
abl-interactor 2
chr6_-_113991945 10.759 NM_009723
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr17_+_85025803 10.715 Dync2li1
dynein cytoplasmic 2 light intermediate chain 1
chr19_+_5740903 10.702 NM_008520
Ltbp3
latent transforming growth factor beta binding protein 3
chr4_+_137283714 10.637 Rap1gap
Rap1 GTPase-activating protein
chr2_-_127481868 10.634 Mal
myelin and lymphocyte protein, T-cell differentiation protein
chr17_+_85025830 10.632 NM_172256
Dync2li1
dynein cytoplasmic 2 light intermediate chain 1
chrX_-_101017286 10.623 NM_009197
Slc16a2
solute carrier family 16 (monocarboxylic acid transporters), member 2
chr3_+_55265654 10.602 NM_001111051
NM_001111052
NM_001195539
NM_001195540
Dclk1



doublecortin-like kinase 1



chr1_-_191167582 10.585 NM_010607
Kcnk2
potassium channel, subfamily K, member 2
chr15_+_89284625 10.579 Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr2_+_92439758 10.578 NM_023850
Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr18_-_33623400 10.559 NM_001109989
D0H4S114
DNA segment, human D4S114
chr2_+_3035692 10.533 Fam171a1
family with sequence similarity 171, member A1
chr9_+_103014374 10.468 NM_173781
Rab6b
RAB6B, member RAS oncogene family
chr18_-_25912453 10.457 NM_001146292
NM_001146293
NM_001146294
NM_001146295
NM_001174074
NM_133195
Celf4





CUGBP, Elav-like family member 4





chr7_-_149843316 10.444 NM_001122737
Igf2
insulin-like growth factor 2
chr6_-_124813922 10.307 NM_013533
Gpr162
G protein-coupled receptor 162
chr2_+_169458802 10.267 Tshz2
teashirt zinc finger family member 2
chr7_+_52955569 10.206 Car11
carbonic anhydrase 11
chr8_-_87323958 10.188 Nfix
nuclear factor I/X
chr3_-_81878554 10.179 NM_001161796
NM_017469
Gucy1b3

guanylate cyclase 1, soluble, beta 3

chr14_+_55555300 10.161 NM_026066
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr18_-_33623069 10.134 NM_001109990
D0H4S114
DNA segment, human D4S114
chr2_+_169459145 10.104 NM_080455
Tshz2
teashirt zinc finger family member 2
chr11_+_102254949 10.099 Rundc3a
RUN domain containing 3A
chr1_+_60466462 10.084 NM_001198570
NM_001198571
NM_198127
Abi2


abl-interactor 2


chr1_-_94998418 10.078 NM_001110315
NM_008440
Kif1a

kinesin family member 1A

chr14_-_7937970 10.004 NM_001024712
Gm3696
predicted gene 3696

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.34 3.83e-28 GO:0032502 developmental process
1.35 2.22e-26 GO:0007275 multicellular organismal development
1.39 1.61e-25 GO:0048731 system development
1.35 1.49e-23 GO:0048856 anatomical structure development
1.25 5.96e-20 GO:0019222 regulation of metabolic process
1.39 6.28e-20 GO:0030154 cell differentiation
1.38 1.55e-19 GO:0048869 cellular developmental process
1.51 2.42e-19 GO:0007399 nervous system development
1.29 3.12e-19 GO:0051179 localization
1.27 5.24e-19 GO:0031323 regulation of cellular metabolic process
1.63 1.62e-18 GO:0048699 generation of neurons
1.32 3.82e-18 GO:0048522 positive regulation of cellular process
1.26 9.68e-18 GO:0080090 regulation of primary metabolic process
1.32 4.96e-17 GO:0048519 negative regulation of biological process
1.29 7.22e-17 GO:0016043 cellular component organization
1.29 1.29e-16 GO:0048518 positive regulation of biological process
1.58 1.40e-16 GO:0022008 neurogenesis
1.33 4.46e-16 GO:0048523 negative regulation of cellular process
1.41 6.44e-15 GO:0023051 regulation of signaling
1.27 7.96e-15 GO:0071840 cellular component organization or biogenesis
1.39 1.33e-14 GO:0051239 regulation of multicellular organismal process
1.28 3.11e-14 GO:0051234 establishment of localization
1.35 6.37e-14 GO:0065008 regulation of biological quality
1.24 6.80e-14 GO:0060255 regulation of macromolecule metabolic process
1.38 2.04e-13 GO:0065009 regulation of molecular function
1.27 3.41e-13 GO:0006810 transport
1.26 1.04e-12 GO:0051171 regulation of nitrogen compound metabolic process
1.26 2.53e-12 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 4.78e-12 GO:0051128 regulation of cellular component organization
1.62 1.13e-11 GO:0030182 neuron differentiation
1.48 1.60e-11 GO:0048468 cell development
1.14 1.91e-11 GO:0044237 cellular metabolic process
1.37 2.31e-11 GO:0009653 anatomical structure morphogenesis
1.39 3.92e-11 GO:0050790 regulation of catalytic activity
1.39 5.35e-11 GO:0009966 regulation of signal transduction
1.68 5.40e-11 GO:0048666 neuron development
1.28 9.44e-11 GO:0071842 cellular component organization at cellular level
1.13 1.01e-10 GO:0008152 metabolic process
1.76 1.19e-10 GO:0031175 neuron projection development
1.67 2.61e-10 GO:0060284 regulation of cell development
1.24 2.70e-10 GO:0031326 regulation of cellular biosynthetic process
1.24 2.98e-10 GO:0009889 regulation of biosynthetic process
1.24 3.26e-10 GO:0010468 regulation of gene expression
1.14 3.39e-10 GO:0044238 primary metabolic process
1.47 3.94e-10 GO:0045595 regulation of cell differentiation
1.30 5.68e-10 GO:0048513 organ development
1.60 6.74e-10 GO:0030030 cell projection organization
1.31 1.11e-09 GO:0048583 regulation of response to stimulus
1.40 1.58e-09 GO:0050793 regulation of developmental process
1.26 2.49e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.39 3.02e-09 GO:0010646 regulation of cell communication
1.39 3.96e-09 GO:0032879 regulation of localization
1.64 4.69e-09 GO:0044057 regulation of system process
1.23 7.08e-09 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.23 1.33e-08 GO:0010556 regulation of macromolecule biosynthetic process
1.41 1.80e-08 GO:2000026 regulation of multicellular organismal development
1.24 2.31e-08 GO:0051252 regulation of RNA metabolic process
1.24 3.99e-08 GO:0006355 regulation of transcription, DNA-dependent
1.37 8.98e-08 GO:0051641 cellular localization
1.75 1.16e-07 GO:0048812 neuron projection morphogenesis
1.43 2.14e-07 GO:0051049 regulation of transport
1.99 2.24e-07 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.99 2.24e-07 GO:0022604 regulation of cell morphogenesis
1.35 2.39e-07 GO:0035556 intracellular signal transduction
1.32 4.75e-07 GO:0033036 macromolecule localization
1.36 5.59e-07 GO:0031324 negative regulation of cellular metabolic process
1.34 5.83e-07 GO:0009892 negative regulation of metabolic process
1.78 6.16e-07 GO:0007409 axonogenesis
1.14 7.51e-07 GO:0044260 cellular macromolecule metabolic process
1.65 1.06e-06 GO:0048858 cell projection morphogenesis
1.49 1.38e-06 GO:0072358 cardiovascular system development
1.49 1.38e-06 GO:0072359 circulatory system development
1.72 1.89e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.63 2.27e-06 GO:0032990 cell part morphogenesis
1.61 2.80e-06 GO:0050767 regulation of neurogenesis
1.63 2.95e-06 GO:0000904 cell morphogenesis involved in differentiation
1.13 3.20e-06 GO:0043170 macromolecule metabolic process
1.34 3.85e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.50 4.79e-06 GO:0032989 cellular component morphogenesis
1.52 5.68e-06 GO:0000902 cell morphogenesis
1.57 6.46e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.28 7.76e-06 GO:0009893 positive regulation of metabolic process
1.16 9.29e-06 GO:0006807 nitrogen compound metabolic process
1.55 1.46e-05 GO:0051960 regulation of nervous system development
1.32 1.53e-05 GO:0051246 regulation of protein metabolic process
1.58 1.54e-05 GO:0009894 regulation of catabolic process
1.33 1.59e-05 GO:0032268 regulation of cellular protein metabolic process
1.73 3.12e-05 GO:0031344 regulation of cell projection organization
1.15 3.95e-05 GO:0034641 cellular nitrogen compound metabolic process
1.62 4.92e-05 GO:0045664 regulation of neuron differentiation
1.56 4.98e-05 GO:0001944 vasculature development
1.36 6.00e-05 GO:0009890 negative regulation of biosynthetic process
1.27 6.47e-05 GO:0031325 positive regulation of cellular metabolic process
1.23 6.48e-05 GO:0006351 transcription, DNA-dependent
1.40 6.71e-05 GO:0009887 organ morphogenesis
1.58 7.31e-05 GO:0001568 blood vessel development
1.27 7.46e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.34 7.56e-05 GO:0051649 establishment of localization in cell
1.23 8.51e-05 GO:0032774 RNA biosynthetic process
1.77 9.92e-05 GO:0010975 regulation of neuron projection development
1.74 1.14e-04 GO:0034762 regulation of transmembrane transport
1.52 1.60e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.60 1.73e-04 GO:0007268 synaptic transmission
1.65 1.83e-04 GO:0031644 regulation of neurological system process
1.35 1.84e-04 GO:0031399 regulation of protein modification process
1.30 1.90e-04 GO:0008104 protein localization
1.46 2.05e-04 GO:0007417 central nervous system development
1.30 2.21e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.35 2.48e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.52 3.41e-04 GO:0019226 transmission of nerve impulse
1.52 3.41e-04 GO:0035637 multicellular organismal signaling
1.34 3.65e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.66 3.93e-04 GO:0051969 regulation of transmission of nerve impulse
1.29 4.04e-04 GO:0010941 regulation of cell death
1.41 4.11e-04 GO:0051094 positive regulation of developmental process
1.36 4.91e-04 GO:0019220 regulation of phosphate metabolic process
1.36 4.91e-04 GO:0051174 regulation of phosphorus metabolic process
1.37 6.19e-04 GO:0016192 vesicle-mediated transport
1.40 7.53e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.52 7.90e-04 GO:0045596 negative regulation of cell differentiation
1.31 8.76e-04 GO:0010628 positive regulation of gene expression
1.34 9.55e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.61 1.06e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.29 1.23e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.40 1.26e-03 GO:0043009 chordate embryonic development
1.39 1.27e-03 GO:0019725 cellular homeostasis
1.40 1.35e-03 GO:0009792 embryo development ending in birth or egg hatching
1.15 1.37e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 1.41e-03 GO:0051254 positive regulation of RNA metabolic process
1.44 1.42e-03 GO:0040008 regulation of growth
1.54 1.64e-03 GO:0006140 regulation of nucleotide metabolic process
1.45 1.88e-03 GO:0045597 positive regulation of cell differentiation
1.44 1.90e-03 GO:0007267 cell-cell signaling
1.31 1.91e-03 GO:0009790 embryo development
1.32 1.94e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.29 1.99e-03 GO:0009888 tissue development
1.35 2.42e-03 GO:0051253 negative regulation of RNA metabolic process
1.48 2.49e-03 GO:0051130 positive regulation of cellular component organization
2.85 2.60e-03 GO:0010717 regulation of epithelial to mesenchymal transition
1.27 2.85e-03 GO:0009891 positive regulation of biosynthetic process
1.59 2.86e-03 GO:0006897 endocytosis
1.59 2.86e-03 GO:0010324 membrane invagination
1.46 2.88e-03 GO:0008285 negative regulation of cell proliferation
1.29 2.91e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 3.00e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.17 3.00e-03 GO:0016070 RNA metabolic process
1.34 3.30e-03 GO:0042325 regulation of phosphorylation
1.42 3.42e-03 GO:0016044 cellular membrane organization
1.34 3.84e-03 GO:0007154 cell communication
1.63 4.00e-03 GO:0050804 regulation of synaptic transmission
1.44 4.19e-03 GO:0090066 regulation of anatomical structure size
1.34 4.41e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.28 4.43e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.47 4.67e-03 GO:0007420 brain development
1.41 4.74e-03 GO:0061024 membrane organization
1.44 4.77e-03 GO:0051093 negative regulation of developmental process
1.28 4.84e-03 GO:0042592 homeostatic process
1.74 5.73e-03 GO:0010720 positive regulation of cell development
1.07 5.82e-03 GO:0065007 biological regulation
1.51 6.03e-03 GO:0001501 skeletal system development
1.54 6.09e-03 GO:0008361 regulation of cell size
1.35 6.55e-03 GO:0001932 regulation of protein phosphorylation
2.07 6.58e-03 GO:0045667 regulation of osteoblast differentiation
1.32 7.18e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 7.37e-03 GO:0006811 ion transport
1.35 7.87e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.52 8.85e-03 GO:0046928 regulation of neurotransmitter secretion
1.39 9.89e-03 GO:0070727 cellular macromolecule localization
1.14 9.98e-03 GO:0044249 cellular biosynthetic process
1.31 1.01e-02 GO:0010629 negative regulation of gene expression
1.26 1.05e-02 GO:0043067 regulation of programmed cell death
1.27 1.24e-02 GO:0022607 cellular component assembly
2.30 1.28e-02 GO:0051149 positive regulation of muscle cell differentiation
1.05 1.37e-02 GO:0009987 cellular process
1.59 1.38e-02 GO:0043269 regulation of ion transport
1.36 1.42e-02 GO:0030001 metal ion transport
2.08 1.54e-02 GO:0070588 calcium ion transmembrane transport
1.27 1.57e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.74 1.60e-02 GO:0003012 muscle system process
1.38 1.69e-02 GO:0034613 cellular protein localization
1.49 1.72e-02 GO:0007264 small GTPase mediated signal transduction
1.49 1.78e-02 GO:0031329 regulation of cellular catabolic process
1.54 1.83e-02 GO:0001558 regulation of cell growth
1.25 1.99e-02 GO:0042981 regulation of apoptosis
1.13 2.09e-02 GO:0009058 biosynthetic process
1.07 2.33e-02 GO:0050789 regulation of biological process
1.79 2.38e-02 GO:0006936 muscle contraction
1.67 2.43e-02 GO:0030811 regulation of nucleotide catabolic process
1.67 2.43e-02 GO:0033121 regulation of purine nucleotide catabolic process
1.30 2.55e-02 GO:0016265 death
1.31 2.71e-02 GO:0012501 programmed cell death
1.38 2.71e-02 GO:0060341 regulation of cellular localization
1.31 2.78e-02 GO:0022610 biological adhesion
1.51 2.89e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.67 3.14e-02 GO:0010959 regulation of metal ion transport
1.37 3.16e-02 GO:0007010 cytoskeleton organization
1.65 3.18e-02 GO:0006813 potassium ion transport
1.35 3.25e-02 GO:0010942 positive regulation of cell death
1.52 3.44e-02 GO:0051129 negative regulation of cellular component organization
1.31 3.47e-02 GO:0007155 cell adhesion
1.18 3.63e-02 GO:0006464 protein modification process
1.50 3.63e-02 GO:0048514 blood vessel morphogenesis
1.29 3.72e-02 GO:0008219 cell death
1.40 3.73e-02 GO:0045859 regulation of protein kinase activity
1.49 3.87e-02 GO:0061061 muscle structure development
1.32 4.02e-02 GO:0006812 cation transport
1.29 4.38e-02 GO:0006468 protein phosphorylation
1.31 4.76e-02 GO:0046907 intracellular transport
1.15 4.91e-02 GO:0044267 cellular protein metabolic process
1.07 4.91e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.19 3.02e-56 GO:0005622 intracellular
1.18 6.74e-51 GO:0044424 intracellular part
1.20 1.41e-37 GO:0005737 cytoplasm
1.17 6.28e-34 GO:0043226 organelle
1.17 1.73e-33 GO:0043229 intracellular organelle
1.17 6.67e-27 GO:0043227 membrane-bounded organelle
1.17 8.92e-27 GO:0043231 intracellular membrane-bounded organelle
1.81 9.48e-24 GO:0043005 neuron projection
1.08 2.77e-23 GO:0005623 cell
1.08 2.77e-23 GO:0044464 cell part
1.83 1.82e-21 GO:0045202 synapse
1.19 8.40e-19 GO:0044444 cytoplasmic part
1.51 1.12e-18 GO:0042995 cell projection
1.24 1.70e-16 GO:0071944 cell periphery
1.19 4.14e-16 GO:0005634 nucleus
1.44 3.00e-15 GO:0000267 cell fraction
1.23 4.34e-15 GO:0005886 plasma membrane
1.84 8.94e-15 GO:0044456 synapse part
1.26 2.12e-14 GO:0043234 protein complex
1.32 7.14e-13 GO:0044459 plasma membrane part
1.46 8.61e-13 GO:0005626 insoluble fraction
1.88 2.90e-12 GO:0030424 axon
1.35 3.47e-12 GO:0005829 cytosol
1.46 7.05e-12 GO:0005624 membrane fraction
1.74 1.18e-11 GO:0044297 cell body
1.76 1.79e-11 GO:0043025 neuronal cell body
1.53 4.49e-11 GO:0030054 cell junction
1.79 4.82e-11 GO:0030425 dendrite
1.21 6.38e-11 GO:0032991 macromolecular complex
1.62 8.46e-10 GO:0044463 cell projection part
1.17 8.48e-09 GO:0044446 intracellular organelle part
1.16 1.33e-08 GO:0044422 organelle part
1.89 2.51e-07 GO:0045211 postsynaptic membrane
1.39 3.33e-07 GO:0031982 vesicle
1.62 7.10e-07 GO:0048471 perinuclear region of cytoplasm
1.34 7.14e-07 GO:0005794 Golgi apparatus
1.27 7.31e-07 GO:0005856 cytoskeleton
1.38 3.49e-06 GO:0031410 cytoplasmic vesicle
1.81 3.93e-06 GO:0030135 coated vesicle
1.35 6.41e-06 GO:0012505 endomembrane system
1.59 6.64e-06 GO:0044431 Golgi apparatus part
1.84 9.30e-06 GO:0030136 clathrin-coated vesicle
1.76 1.14e-05 GO:0034702 ion channel complex
1.52 1.34e-05 GO:0005625 soluble fraction
1.41 2.11e-05 GO:0031988 membrane-bounded vesicle
2.63 2.23e-05 GO:0042734 presynaptic membrane
1.52 5.08e-05 GO:0031012 extracellular matrix
1.95 5.65e-05 GO:0034703 cation channel complex
1.41 7.61e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.29 1.48e-04 GO:0044430 cytoskeletal part
2.57 1.56e-04 GO:0043198 dendritic shaft
1.80 1.71e-04 GO:0033267 axon part
2.02 2.06e-04 GO:0014069 postsynaptic density
1.89 5.64e-04 GO:0008021 synaptic vesicle
1.97 8.56e-04 GO:0030426 growth cone
1.95 9.70e-04 GO:0030427 site of polarized growth
1.35 1.03e-03 GO:0015630 microtubule cytoskeleton
1.23 1.42e-03 GO:0031090 organelle membrane
1.48 1.74e-03 GO:0005578 proteinaceous extracellular matrix
1.77 2.16e-03 GO:0044420 extracellular matrix part
1.88 5.47e-03 GO:0042383 sarcolemma
1.59 5.62e-03 GO:0031252 cell leading edge
1.92 6.02e-03 GO:0044309 neuron spine
1.14 7.24e-03 GO:0043228 non-membrane-bounded organelle
1.14 7.24e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.66 7.69e-03 GO:0019717 synaptosome
1.23 9.90e-03 GO:0005783 endoplasmic reticulum
1.59 1.22e-02 GO:0044433 cytoplasmic vesicle part
1.33 1.48e-02 GO:0009986 cell surface
1.59 1.59e-02 GO:0030659 cytoplasmic vesicle membrane
1.56 1.83e-02 GO:0012506 vesicle membrane
1.87 2.27e-02 GO:0043197 dendritic spine
1.79 2.92e-02 GO:0030027 lamellipodium
1.57 3.24e-02 GO:0000139 Golgi membrane
1.44 4.01e-02 GO:0045177 apical part of cell
1.21 4.78e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.33 4.42e-57 GO:0005515 protein binding
1.18 1.38e-50 GO:0005488 binding
1.49 6.42e-13 GO:0019899 enzyme binding
1.57 3.01e-10 GO:0008092 cytoskeletal protein binding
1.42 5.15e-09 GO:0030234 enzyme regulator activity
1.53 5.39e-09 GO:0019904 protein domain specific binding
1.19 1.59e-08 GO:0046872 metal ion binding
1.18 3.49e-08 GO:0043167 ion binding
1.18 4.27e-08 GO:0043169 cation binding
1.55 4.82e-07 GO:0060589 nucleoside-triphosphatase regulator activity
1.28 2.28e-06 GO:0008270 zinc ion binding
1.25 3.48e-06 GO:0046914 transition metal ion binding
1.51 7.35e-06 GO:0030695 GTPase regulator activity
1.52 2.42e-05 GO:0032403 protein complex binding
1.42 4.92e-05 GO:0005509 calcium ion binding
1.55 7.40e-05 GO:0019900 kinase binding
1.60 7.77e-05 GO:0019901 protein kinase binding
1.28 1.73e-04 GO:0005215 transporter activity
1.30 3.21e-04 GO:0022892 substrate-specific transporter activity
1.30 3.55e-04 GO:0022857 transmembrane transporter activity
1.31 4.50e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.67 4.91e-04 GO:0005244 voltage-gated ion channel activity
1.67 4.91e-04 GO:0022832 voltage-gated channel activity
1.45 4.97e-04 GO:0022838 substrate-specific channel activity
1.51 5.23e-04 GO:0003779 actin binding
1.95 5.77e-04 GO:0030165 PDZ domain binding
1.79 5.82e-04 GO:0022843 voltage-gated cation channel activity
1.33 7.23e-04 GO:0015075 ion transmembrane transporter activity
1.52 9.91e-04 GO:0022836 gated channel activity
1.44 1.17e-03 GO:0005216 ion channel activity
1.86 1.24e-03 GO:0019838 growth factor binding
1.10 1.54e-03 GO:0003824 catalytic activity
1.31 1.97e-03 GO:0046983 protein dimerization activity
1.42 2.21e-03 GO:0015267 channel activity
1.17 2.21e-03 GO:0000166 nucleotide binding
1.25 2.34e-03 GO:0005102 receptor binding
1.52 2.43e-03 GO:0005261 cation channel activity
1.41 2.60e-03 GO:0022803 passive transmembrane transporter activity
1.98 4.99e-03 GO:0019199 transmembrane receptor protein kinase activity
1.45 5.20e-03 GO:0008047 enzyme activator activity
1.36 5.30e-03 GO:0008324 cation transmembrane transporter activity
1.50 5.63e-03 GO:0005083 small GTPase regulator activity
1.26 5.86e-03 GO:0030528 transcription regulator activity
3.17 6.59e-03 GO:0005246 calcium channel regulator activity
1.14 8.57e-03 GO:0003676 nucleic acid binding
2.01 1.36e-02 GO:0042625 ATPase activity, coupled to transmembrane movement of ions
2.44 1.53e-02 GO:0035254 glutamate receptor binding
1.27 1.72e-02 GO:0001071 nucleic acid binding transcription factor activity
1.27 1.72e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.26 2.65e-02 GO:0042802 identical protein binding
2.06 2.74e-02 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
1.16 3.36e-02 GO:0032553 ribonucleotide binding
1.16 4.00e-02 GO:0032555 purine ribonucleotide binding
1.50 4.84e-02 GO:0005096 GTPase activator activity