Motif ID: NKX2-1,4.p2

Z-value: 0.993


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
Nkx2-1 21869 NK2 homeobox 1
Nkx2-4 228731 NK2 transcription factor related, locus 4 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1chr12_-_576378940.145.7e-02Click!
Nkx2-4chr2_-_1469110800.102.0e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_104284572 22.641 NM_172435
P2ry10
purinergic receptor P2Y, G-protein coupled 10
chr18_-_9995729 15.031 Usp14
ubiquitin specific peptidase 14
chr15_-_102062309 14.139 Itgb7
integrin beta 7
chr6_-_122560002 13.990 Gdf3
growth differentiation factor 3
chr7_-_31663995 12.759 NM_009845
Cd22
CD22 antigen
chr10_+_7552260 11.922 NM_172785
Zc3h12d
zinc finger CCCH type containing 12D
chr3_+_116564564 11.465 NM_009146
Frrs1
ferric-chelate reductase 1
chr6_-_122560022 10.996 NM_008108
Gdf3
growth differentiation factor 3
chr15_-_102062331 9.607 NM_013566
Itgb7
integrin beta 7
chr5_-_65323937 9.564 NM_030682
Tlr1
toll-like receptor 1
chr8_-_8666771 9.461 Arglu1
arginine and glutamate rich 1
chr7_-_53971038 8.685 NM_011315
Saa3
serum amyloid A 3
chr15_-_78603874 7.728 NM_008595
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_-_78403110 7.718 NM_009008
Rac2
RAS-related C3 botulinum substrate 2
chr17_+_88382830 7.653 Msh6
mutS homolog 6 (E. coli)
chr10_+_87553816 7.634 NM_029971
Pmch
pro-melanin-concentrating hormone
chr2_-_73291933 7.532 Wipf1
WAS/WASL interacting protein family, member 1
chr2_+_61642509 7.249 NM_009322
Tbr1
T-box brain gene 1
chr13_-_108516475 7.205 Zswim6
zinc finger, SWIM domain containing 6
chr17_-_57333491 7.024 NM_019418
Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_87546558 6.642 NM_013673
Sp100
nuclear antigen Sp100
chr9_+_55937776 5.833 NM_011193
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr11_+_87895626 5.551 Vezf1
vascular endothelial zinc finger 1
chr8_-_127363674 5.526


chr3_-_15575064 5.526 NM_001173460
Sirpb1b
signal-regulatory protein beta 1B
chr6_+_39331379 5.451 NM_011226
Rab19
RAB19, member RAS oncogene family
chr9_+_89094110 5.412 NM_007534
Bcl2a1a
Bcl2a1b
B-cell leukemia/lymphoma 2 related protein A1a
B-cell leukemia/lymphoma 2 related protein A1b
chr4_-_142718290 5.262 Prdm2
PR domain containing 2, with ZNF domain
chr2_-_29103559 5.115 NM_133500
NM_133501
Ntng2

netrin G2

chr17_+_34726750 5.026 NM_134116
Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr14_-_56880985 4.843 NM_013542
Gzmb
granzyme B
chr9_-_43951401 4.487


chr1_-_172906094 4.462 NM_001077189
NM_010187
Fcgr2b

Fc receptor, IgG, low affinity IIb

chr7_+_135273060 4.331 NM_021334
Itgax
integrin alpha X
chr4_-_120597563 4.038 NM_001160043
NM_028457
Dem1

defects in morphology 1 homolog (S. cerevisiae)

chr9_-_113563906 3.970 Pdcd6ip
programmed cell death 6 interacting protein
chr17_+_8428907 3.885 NM_001190333
Ccr6
chemokine (C-C motif) receptor 6
chr9_-_88626434 3.875 Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr1_-_181682859 3.799 Ahctf1
AT hook containing transcription factor 1
chr3_+_125106995 3.785 NM_022565
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr15_+_98885599 3.723 NM_001163588
NM_001163589
NM_013639
Prph


peripherin


chr9_-_44550590 3.702


chr3_+_87924435 3.692 Iqgap3
IQ motif containing GTPase activating protein 3
chr7_-_90883999 3.667 NM_010551
Il16
interleukin 16
chr9_-_88626613 3.622 NM_007536
Bcl2a1d
B-cell leukemia/lymphoma 2 related protein A1d
chr2_+_139996381 3.622 NM_027093
2310003L22Rik
RIKEN cDNA 2310003L22 gene
chr7_+_11983263 3.554 NM_001110316
Zscan4f
zinc finger and SCAN domain containing 4F
chr9_-_14708327 3.511 NM_022888
NM_176807
Folr4

folate receptor 4 (delta)

chr7_-_11896030 3.502 NM_001161802
Zscan4e
zinc finger and SCAN domain containing 4E
chr1_+_173697246 3.502 NM_013730
Slamf1
signaling lymphocytic activation molecule family member 1
chr11_-_79056525 3.457 NM_001042565
Wsb1
WD repeat and SOCS box-containing 1
chr12_-_101397818 3.439 NM_183155
BC002230
cDNA sequence BC002230
chr7_-_11490398 3.428 NM_001185173
Zscan4b
zinc finger and SCAN domain containing 4B
chr6_-_69494873 3.390 Igkv4-57-1
immunoglobulin kappa variable 4-57-1
chr10_+_80291835 3.326


chr1_-_75132608 3.287 1810031K17Rik
RIKEN cDNA 1810031K17 gene
chr7_+_29666674 3.276 NM_001110807
Capn12
calpain 12
chr9_+_88851757 3.213 NM_009742
Bcl2a1a
B-cell leukemia/lymphoma 2 related protein A1a
chr2_+_129838084 3.209 NM_009374
Tgm3
transglutaminase 3, E polypeptide
chr11_+_117864696 3.181 Pgs1
phosphatidylglycerophosphate synthase 1
chr9_-_21035212 3.151 Keap1
kelch-like ECH-associated protein 1
chrX_+_104871850 3.115 NM_145224
Tbx22
T-box 22
chr5_+_53946944 2.955 NM_001080928
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr4_+_99322989 2.929 NM_010425
Foxd3
forkhead box D3
chr7_-_88711829 2.921 NM_172904
Fsd2
fibronectin type III and SPRY domain containing 2
chr16_+_89206105 2.834 NM_001163615
Krtap20-2
keratin associated protein 20-2
chrX_+_98494487 2.822 NM_172932
Nlgn3
neuroligin 3
chr14_-_49282546 2.804 NM_144841
Otx2
orthodenticle homolog 2 (Drosophila)
chr4_-_136891931 2.784 Cdc42
cell division cycle 42 homolog (S. cerevisiae)
chr17_+_87762817 2.779 Ttc7
tetratricopeptide repeat domain 7
chr6_-_69651268 2.765


chr3_+_93197619 2.724 NM_009100
Rptn
repetin
chr5_-_121199781 2.705 NM_145227
Oas2
2'-5' oligoadenylate synthetase 2
chr17_+_33692639 2.687 NM_053214
Myo1f
myosin IF
chr16_+_26463220 2.666 NM_053241
Cldn16
claudin 16
chr1_+_40572206 2.659 NM_010553
Il18rap
interleukin 18 receptor accessory protein
chr11_-_99471502 2.653 NM_001099346
Gm11937
predicted gene 11937
chr1_-_65109982 2.610 NM_007776
Crygd
crystallin, gamma D
chr16_-_38445988 2.605 Adprh
ADP-ribosylarginine hydrolase
chr3_+_89324085 2.599 NM_080466
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr2_-_156754104 2.589 Ndrg3
N-myc downstream regulated gene 3
chr1_-_75132977 2.572 1810031K17Rik
RIKEN cDNA 1810031K17 gene
chr5_+_97520188 2.510 Bmp2k
BMP2 inducible kinase
chr2_+_180447250 2.505 NM_029607
2310003C23Rik
RIKEN cDNA 2310003C23 gene
chr7_-_34977928 2.499 Pdcd2l
programmed cell death 2-like
chr18_+_32416881 2.458 Ercc3
excision repair cross-complementing rodent repair deficiency, complementation group 3
chr8_+_97269489 2.389 NM_009137
Ccl22
chemokine (C-C motif) ligand 22
chr10_-_61885155 2.379 NM_145419
Hkdc1
hexokinase domain containing 1
chr12_+_87027595 2.350 NM_016767
Batf
basic leucine zipper transcription factor, ATF-like
chr4_+_123613778 2.347 Rragc
Ras-related GTP binding C
chr7_-_133514716 2.345 Spns1
spinster homolog 1 (Drosophila)
chr9_+_7272513 2.345 NM_008607
Mmp13
matrix metallopeptidase 13
chrX_+_146029143 2.328 NM_001037716
Gm10439
predicted gene 10439
chr6_-_69367406 2.325 Igkv4-68
immunoglobulin kappa variable 4-68
chr7_-_147174332 2.294 Adam8
a disintegrin and metallopeptidase domain 8
chr7_+_3336653 2.284 NM_133189
Cacng7
calcium channel, voltage-dependent, gamma subunit 7
chr7_+_54110611 2.276 Ldha
lactate dehydrogenase A
chr4_-_129250806 2.220 NM_001162433
Lck
lymphocyte protein tyrosine kinase
chr13_+_35751730 2.215 NM_009881
Cdyl
chromodomain protein, Y chromosome-like
chr6_-_69557773 2.207


chr3_+_95465860 2.183 Mcl1
myeloid cell leukemia sequence 1
chr2_+_154374639 2.170 NM_029305
1700003F12Rik
RIKEN cDNA 1700003F12 gene
chr8_+_97835414 2.167 NM_199455
NM_028532
Tepp

testis, prostate and placenta expressed

chr1_-_184246785 2.138 Fbxo28
F-box protein 28
chr11_+_30854464 2.133 Asb3
ankyrin repeat and SOCS box-containing 3
chr9_+_7792286 2.120 Tmem123
transmembrane protein 123
chr6_+_123179860 2.119 NM_001190320
NM_001190321
NM_020001
Clec4n


C-type lectin domain family 4, member n


chrX_+_145098146 2.103 NM_001114400
Gm10439
Gm15127
predicted gene 10439
predicted gene 15127
chr14_-_51875785 2.094 NM_053113
Ear11
eosinophil-associated, ribonuclease A family, member 11
chr13_-_58456221 2.090 NM_175214
Kif27
kinesin family member 27
chr11_+_100442831 2.081 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr18_+_3435267 2.079 Cul2
cullin 2
chrX_-_140367467 2.027 NM_001110222
NM_001110223
NM_001110224
NM_010025
Dcx



doublecortin



chrX_-_93488752 2.012 NM_177789
Vsig4
V-set and immunoglobulin domain containing 4
chr17_-_51965912 2.007 NM_001163631
Satb1
special AT-rich sequence binding protein 1
chr7_-_91827857 2.000 NM_022985
Zfand6
zinc finger, AN1-type domain 6
chr9_+_122481617 1.993 9530059O14Rik
RIKEN cDNA 9530059O14 gene
chr5_-_138605998 1.991


chr3_-_15426426 1.989 NM_001002898
Sirpb1a
signal-regulatory protein beta 1A
chr6_-_69193672 1.970


chr12_-_86097674 1.943 Npc2
Niemann Pick type C2
chr6_-_69599335 1.871


chr19_+_38207270 1.859 NM_001170959
NM_033614
Pde6c

phosphodiesterase 6C, cGMP specific, cone, alpha prime

chr2_+_153956082 1.826 NM_028528
1700058C13Rik
RIKEN cDNA 1700058C13 gene
chr9_+_123428782 1.810 Limd1
LIM domains containing 1
chr10_+_127669118 1.784 NM_001136082
NM_001164080
NM_001164081
Timeless


timeless homolog (Drosophila)


chr3_-_108707417 1.757 Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr16_+_49913305 1.738 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr7_-_88049882 1.736 NM_026523
Nmb
neuromedin B
chr1_+_175603760 1.709 NM_001162938
Pydc3
pyrin domain containing 3
chr11_-_101139357 1.706


chr2_-_34610751 1.698 NM_025709
Gapvd1
GTPase activating protein and VPS9 domains 1
chr17_+_31432427 1.686 NM_153062
Slc37a1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr4_+_9196439 1.662 NM_028940
Clvs1
clavesin 1
chr17_+_6893421 1.652 NM_183370
Sytl3
synaptotagmin-like 3
chr7_+_54110791 1.636


chr9_+_64809499 1.635 2010321M09Rik
RIKEN cDNA 2010321M09 gene
chr9_-_91255831 1.610 Zic1
zinc finger protein of the cerebellum 1
chrX_-_70535853 1.582 NM_031493
Xlr5c
X-linked lymphocyte-regulated 5C
chr1_+_87423176 1.575 Csprs
component of Sp100-rs
chr8_+_49184445 1.568 NM_001161516
Dctd
dCMP deaminase
chr15_-_72929166 1.561 2310051F07Rik
RIKEN cDNA 2310051F07 gene
chr3_+_145784635 1.551 NM_134160
Mcoln3
mucolipin 3
chr11_+_53534295 1.520 NM_010558
Il5
interleukin 5
chr15_+_54242324 1.510 NM_173422
Colec10
collectin sub-family member 10
chr3_-_6620440 1.504 NM_027048
1700008P02Rik
RIKEN cDNA 1700008P02 gene
chrX_+_145882159 1.502 NM_001122734
NM_011022
Gm15085
Ott
Gm15107
predicted gene 15085
ovary testis transcribed
predicted gene 15107
chr18_-_61874531 1.484 Grpel2
GrpE-like 2, mitochondrial
chr1_-_59220232 1.474 NM_001164682
Mpp4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr6_-_129050920 1.458 NM_153506
Clec2e
C-type lectin domain family 2, member e
chr19_+_53218486 1.429 NM_013758
Add3
adducin 3 (gamma)
chr4_-_147808800 1.420


chr6_+_83068645 1.414 Mogs
mannosyl-oligosaccharide glucosidase
chr2_-_28477437 1.393 NM_001160406
NM_008114
Gfi1b

growth factor independent 1B

chr7_+_109231629 1.385 NM_001109897
Trpc2
transient receptor potential cation channel, subfamily C, member 2
chr3_-_102739990 1.380 NM_011516
Sycp1
synaptonemal complex protein 1
chr1_+_108835529 1.378 Serpinb12
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
chrX_+_145522857 1.358 NM_001122734
NM_011022
Gm15085
Ott
Gm15107
predicted gene 15085
ovary testis transcribed
predicted gene 15107
chr11_+_3964839 1.355 NM_001029937
Sec14l3
SEC14-like 3 (S. cerevisiae)
chrX_+_144615266 1.352 NM_001122734
NM_011022
NM_001081648
Gm15085
Ott
Gm10439
Gm15107
predicted gene 15085
ovary testis transcribed
predicted gene 10439
predicted gene 15107
chr17_+_74898763 1.344 Yipf4
Yip1 domain family, member 4
chr2_+_79547936 1.332 NM_172420
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr11_+_85413817 1.327 7030407E18Rik
RIKEN cDNA 7030407E18 gene
chr2_+_29917372 1.316 Set
SET nuclear oncogene
chrX_+_145532494 1.314 NM_001122734
NM_011022
Gm15085
Ott
Gm15107
predicted gene 15085
ovary testis transcribed
predicted gene 15107
chrX_+_144749072 1.314 NM_001122734
NM_011022
Gm15085
Ott
Gm15107
predicted gene 15085
ovary testis transcribed
predicted gene 15107
chr11_+_100442602 1.286 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr9_-_103255690 1.286


chr16_-_87486487 1.272 Cct8
chaperonin containing Tcp1, subunit 8 (theta)
chr16_-_88648032 1.260 NM_027105
Krtap26-1
keratin associated protein 26-1
chr1_-_179178874 1.259 NM_011785
Akt3
thymoma viral proto-oncogene 3
chr6_-_91757386 1.258 NM_001159507
Grip2
glutamate receptor interacting protein 2
chr9_-_44334460 1.243 NM_007551
Cxcr5
chemokine (C-X-C motif) receptor 5
chr11_+_30854457 1.242 Asb3
ankyrin repeat and SOCS box-containing 3
chr12_-_105938606 1.240 Dicer1
Dicer1, Dcr-1 homolog (Drosophila)
chrX_-_151013872 1.235 NM_001037167
Gm5647
predicted gene 5647
chr7_-_11751496 1.233 NM_001100186
Zscan4d
zinc finger and SCAN domain containing 4D
chr19_+_21354915 1.233 Zfand5
zinc finger, AN1-type domain 5
chr5_+_147762106 1.224 Gtf3a
general transcription factor III A
chr10_+_127669154 1.216 Timeless
timeless homolog (Drosophila)
chr3_+_153507205 1.194 NM_025758
Asb17
ankyrin repeat and SOCS box-containing 17
chr10_-_30375572 1.177 NM_001111267
Ncoa7
nuclear receptor coactivator 7
chr15_+_103129767 1.176


chr17_-_45796257 1.172 NM_001013767
Capn11
calpain 11
chr15_-_101723333 1.171 NM_001033177
Krt76
keratin 76
chr1_-_188573165 1.166 NM_026041
Rrp15
ribosomal RNA processing 15 homolog (S. cerevisiae)
chr2_+_151736942 1.158 NM_009641
Angpt4
angiopoietin 4
chr19_+_58586482 1.148 NM_029372
1700011F14Rik
RIKEN cDNA 1700011F14 gene
chr4_-_117438214 1.146 NM_029416
Klf17
Kruppel-like factor 17
chr9_+_124036265 1.135 NM_009917
Ccr5
chemokine (C-C motif) receptor 5
chr1_-_38721799 1.131 NM_010678
Aff3
AF4/FMR2 family, member 3
chr9_-_71743854 1.131 Tcf12
transcription factor 12
chr2_-_6805937 1.129 NM_001110228
NM_001160293
NM_010160
Celf2


CUGBP, Elav-like family member 2


chr6_-_99385338 1.128 NM_053202
Foxp1
forkhead box P1
chr9_+_123429291 1.127 Limd1
LIM domains containing 1
chr8_-_44226818 1.126 NM_177742
Triml1
tripartite motif family-like 1
chrX_+_13209894 1.115 NM_011823
Gpr34
G protein-coupled receptor 34
chr5_+_44260035 1.111 NM_007646
Cd38
CD38 antigen
chr6_+_142723841 1.104 Cmas
cytidine monophospho-N-acetylneuraminic acid synthetase
chr12_+_106923552 1.085 NM_178613
4933433P14Rik
RIKEN cDNA 4933433P14 gene

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.27 1.43e-02 GO:0002376 immune system process

Nothing significant found in compartment category.

Nothing significant found in function category.