Motif ID: NKX2-2,8.p2

Z-value: 1.126


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
Nkx2-2 18088 NK2 transcription factor related, locus 2 (Drosophila)
Nkx2-9 18094 NK2 transcription factor related, locus 9 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9chr12_-_57714253-0.092.5e-01Click!
Nkx2-2chr2_-_1470119900.027.8e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_79337178 17.777 Evi2b
ecotropic viral integration site 2b
chr7_-_52494097 14.535 NM_007645
Cd37
CD37 antigen
chr1_+_40497472 14.440 NM_001025602
Il1rl1
interleukin 1 receptor-like 1
chr7_-_52494453 14.319 Cd37
CD37 antigen
chr1_-_140071818 13.277 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr1_+_132762248 12.373 Faim3
Fas apoptotic inhibitory molecule 3
chr16_+_36935029 11.787 NM_008225
Hcls1
hematopoietic cell specific Lyn substrate 1
chr1_-_140071630 11.323 Ptprc
protein tyrosine phosphatase, receptor type, C
chr16_+_45224449 10.957 NM_001037719
NM_177584
Btla

B and T lymphocyte associated

chr11_-_79337251 10.943 NM_001077496
Evi2b
ecotropic viral integration site 2b
chr19_-_28057437 10.771 NM_001166414
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr10_-_80962881 10.302 NM_010102
S1pr4
sphingosine-1-phosphate receptor 4
chr9_+_51021793 10.183 NM_011136
Pou2af1
POU domain, class 2, associating factor 1
chr10_+_87553816 10.180 NM_029971
Pmch
pro-melanin-concentrating hormone
chr7_+_52091656 9.641 NM_010215
Il4i1
interleukin 4 induced 1
chr1_+_132762353 8.635 NM_026976
Faim3
Fas apoptotic inhibitory molecule 3
chr1_+_175603760 7.482 NM_001162938
Pydc3
pyrin domain containing 3
chr13_+_24706474 7.420 NM_178658
Fam65b
family with sequence similarity 65, member B
chrX_+_104344792 7.364 NM_001122595
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr6_-_129187965 7.276 2310001H17Rik
RIKEN cDNA 2310001H17 gene
chr8_-_8666771 7.189 Arglu1
arginine and glutamate rich 1
chr15_-_8273428 7.182 Nipbl
Nipped-B homolog (Drosophila)
chr11_-_16908631 7.094 NM_019549
Plek
pleckstrin
chr4_-_63064369 6.986 NM_001045514
Akna
AT-hook transcription factor
chr5_+_138011078 6.969 NM_015799
Trfr2
transferrin receptor 2
chr19_+_54003803 6.862 Pdcd4
programmed cell death 4
chr19_-_11340591 6.848 NM_007641
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chr18_-_77870871 6.836 2310007O11Rik
RIKEN cDNA 2310007O11 gene
chr1_+_40496493 6.766 NM_010743
Il1rl1
interleukin 1 receptor-like 1
chrX_+_104344953 6.732 NM_175442
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr19_+_12873115 6.427 Lpxn
leupaxin
chr1_-_146024404 6.423 NM_153171
Rgs13
regulator of G-protein signaling 13
chr2_-_4912152 6.381 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr8_-_8667108 6.340 Arglu1
arginine and glutamate rich 1
chr15_-_72926936 6.280 1110029L17Rik
RIKEN cDNA 1110029L17 gene
chr3_-_135988955 6.240 NM_001033350
Bank1
B-cell scaffold protein with ankyrin repeats 1
chr5_+_138011057 6.161 Trfr2
transferrin receptor 2
chr12_+_33987379 6.027 NM_001033436
Atxn7l1
ataxin 7-like 1
chr19_+_12873063 6.009 NM_134152
Lpxn
leupaxin
chr10_+_57365674 5.997 NM_001039052
NM_001039053
Pkib

protein kinase inhibitor beta, cAMP dependent, testis specific

chr14_+_73637697 5.790 NM_175116
Lpar6
lysophosphatidic acid receptor 6
chr14_+_73637961 5.745 Lpar6
lysophosphatidic acid receptor 6
chr10_-_61970481 5.740 NM_011157
Srgn
serglycin
chr3_-_157686385 5.733 NM_026989
Srsf11
serine/arginine-rich splicing factor 11
chr6_+_123212210 5.704 Clec4d
C-type lectin domain family 4, member d
chr16_-_22811458 5.589 NM_009967
Crygs
crystallin, gamma S
chrX_-_98463514 5.572 NM_013563
Il2rg
interleukin 2 receptor, gamma chain
chr1_-_173579057 5.520 Slamf7
SLAM family member 7
chr3_-_51129908 5.377 NM_023502
Elf2
E74-like factor 2
chr1_+_74314377 5.308 Arpc2
actin related protein 2/3 complex, subunit 2
chr4_+_102262447 5.256 NM_001177981
Pde4b
phosphodiesterase 4B, cAMP specific
chr10_+_66648458 5.115 Jmjd1c
jumonji domain containing 1C
chr1_-_175805812 5.000 Mndal
myeloid nuclear differentiation antigen like
chr6_-_48658182 4.991 Gimap6
GTPase, IMAP family member 6
chrX_+_104479684 4.920 NM_001177782
Gpr174
G protein-coupled receptor 174
chr6_-_48658211 4.874 NM_153175
Gimap6
GTPase, IMAP family member 6
chrX_+_104451216 4.798 NM_001177781
NM_001033251
Gpr174

G protein-coupled receptor 174

chr10_-_58904445 4.795 NM_010959
Oit3
oncoprotein induced transcript 3
chr5_-_88956788 4.739 NM_152839
Igj
immunoglobulin joining chain
chrX_+_104344265 4.713 NM_001122596
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr17_+_5341444 4.681 Arid1b
AT rich interactive domain 1B (SWI-like)
chr2_-_7002287 4.641 Celf2
CUGBP, Elav-like family member 2
chr2_+_61642509 4.620 NM_009322
Tbr1
T-box brain gene 1
chr6_-_55631085 4.612 Neurod6
neurogenic differentiation 6
chr13_-_113891176 4.534 NM_010370
Gzma
granzyme A
chr6_+_67846144 4.459


chr11_-_51799215 4.404 Ube2b
ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae)
chr10_-_80962400 4.403 S1pr4
sphingosine-1-phosphate receptor 4
chr5_-_66000506 4.400 B230308N11Rik
RIKEN cDNA B230308N11 gene
chrX_+_12870471 4.367 Ddx3x
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
chr4_-_126540249 4.346 Zmym4
zinc finger, MYM-type 4
chr11_-_114657186 4.256 NM_028055
Btbd17
BTB (POZ) domain containing 17
chr15_-_78403110 4.256 NM_009008
Rac2
RAS-related C3 botulinum substrate 2
chr5_+_66254807 4.215 NM_001081105
Rhoh
ras homolog gene family, member H
chr10_-_88145766 4.163 NM_011461
Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr11_-_79056525 4.147 NM_001042565
Wsb1
WD repeat and SOCS box-containing 1
chr17_-_51965912 4.135 NM_001163631
Satb1
special AT-rich sequence binding protein 1
chr11_-_77538789 4.018 NM_009965
Cryba1
crystallin, beta A1
chr17_-_25482323 4.003 NM_031187
Tpsab1
tryptase alpha/beta 1
chr17_-_33783578 3.997 Hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr6_-_55631256 3.965 NM_009717
Neurod6
neurogenic differentiation 6
chr3_+_88769733 3.934 NM_138679
Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr9_+_35367050 3.880 NM_023292
Pus3
pseudouridine synthase 3
chr9_-_70782614 3.840 NM_008280
Lipc
lipase, hepatic
chr16_+_19760300 3.770 NM_001159407
NM_001159408
NM_054052
B3gnt5


UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5


chr1_-_179178874 3.702 NM_011785
Akt3
thymoma viral proto-oncogene 3
chr7_-_133558344 3.697 NM_009844
Cd19
CD19 antigen
chr7_+_26846512 3.650 NM_007813
Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
chr17_-_35971652 3.640 Tubb5
tubulin, beta 5
chr6_-_122232849 3.635 NM_016970
Klrg1
killer cell lectin-like receptor subfamily G, member 1
chr7_+_113988126 3.632 NM_146596
Olfr703
olfactory receptor 703
chr6_-_55631039 3.586 Neurod6
neurogenic differentiation 6
chr2_-_126719808 3.586 2010106G01Rik
RIKEN cDNA 2010106G01 gene
chr6_-_69367406 3.546 Igkv4-68
immunoglobulin kappa variable 4-68
chr5_-_138605998 3.465


chr16_+_22951144 3.446 NM_053176
Hrg
histidine-rich glycoprotein
chr9_-_40792541 3.425 Crtam
cytotoxic and regulatory T cell molecule
chr5_-_52541869 3.395 Dhx15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr5_+_150242274 3.386 NM_029464
4930588N13Rik
RIKEN cDNA 4930588N13 gene
chr17_+_34052312 3.375


chr19_-_11735008 3.367 NM_001037634
Plac1l
placenta-specific 1-like
chr13_-_94407455 3.357 Bhmt
betaine-homocysteine methyltransferase
chr10_+_23640161 3.296 NM_053205
Taar1
trace amine-associated receptor 1
chr3_+_60432922 3.292 Mbnl1
muscleblind-like 1 (Drosophila)
chr5_-_23012407 3.273 Srpk2
serine/arginine-rich protein specific kinase 2
chr1_+_179374783 3.244 NM_001012330
Zfp238
zinc finger protein 238
chr16_+_22951183 3.207 Hrg
histidine-rich glycoprotein
chr9_-_14587400 3.196 NM_019683
Ankrd49
ankyrin repeat domain 49
chr10_-_116786025 3.185 Cpsf6
cleavage and polyadenylation specific factor 6
chr15_-_66644127 3.165 NM_009192
Sla
src-like adaptor
chr13_+_43497279 3.161 Nol7
nucleolar protein 7
chr3_-_108707417 3.153 Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr11_-_99427891 3.141 NM_023511
Krtap3-1
keratin associated protein 3-1
chrX_-_40627962 3.131 NM_011855
Odz1
odd Oz/ten-m homolog 1 (Drosophila)
chr6_+_116123984 3.117 Gm8203
predicted pseudogene 8203
chr15_-_66644199 3.097 Sla
src-like adaptor
chr8_-_3926756 3.088 NM_001037800
NM_026972
Cd209b

CD209b antigen

chr1_+_177562321 3.080 NM_133809
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr7_-_25873560 3.077


chr6_-_41654290 3.071 NM_032540
Kel
Kell blood group
chr9_+_123715592 3.026 NM_030712
Cxcr6
chemokine (C-X-C motif) receptor 6
chr15_+_44455984 3.025 Ebag9
estrogen receptor-binding fragment-associated gene 9
chr7_+_53339469 3.020


chr1_+_177562307 2.996 Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr16_+_57152994 2.988 Tomm70a
translocase of outer mitochondrial membrane 70 homolog A (yeast)
chr14_-_122364309 2.984 NM_183031
Gpr183
G protein-coupled receptor 183
chr13_-_38694739 2.976


chrX_-_9046362 2.973 NM_007807
Cybb
cytochrome b-245, beta polypeptide
chr5_-_100465086 2.935 Hnrpdl
heterogeneous nuclear ribonucleoprotein D-like
chr6_+_68375560 2.934 Igkv16-104
immunoglobulin kappa variable 16-104
chr10_+_40199817 2.932 Cdk19
cyclin-dependent kinase 19
chr2_+_43604343 2.916 NM_153820
NM_001025377
Arhgap15

Rho GTPase activating protein 15

chrX_+_13209894 2.893 NM_011823
Gpr34
G protein-coupled receptor 34
chr19_+_25127069 2.788 Dock8
dedicator of cytokinesis 8
chr11_+_120466872 2.781 Anapc11
anaphase promoting complex subunit 11
chrX_-_131343508 2.779 Armcx2
armadillo repeat containing, X-linked 2
chr5_-_100391613 2.773 Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr9_-_82826139 2.741 Phip
pleckstrin homology domain interacting protein
chr11_+_46553724 2.740 NM_001166632
Havcr1
hepatitis A virus cellular receptor 1
chr3_-_40659202 2.735 NM_001129886
Gm10731
predicted gene 10731
chr1_+_65973093 2.728 NM_027010
Crygf
crystallin, gamma F
chrX_-_131343759 2.723 NM_001166397
NM_001166398
NM_026139
Armcx2


armadillo repeat containing, X-linked 2


chr8_+_36740640 2.711 Mfhas1
malignant fibrous histiocytoma amplified sequence 1
chrX_-_136533089 2.704 NM_001172147
NM_001172148
NM_153586
Rbm41


RNA binding motif protein 41


chr1_-_178737254 2.693 NM_001099637
Cep170
centrosomal protein 170
chr12_+_33535650 2.687 Nampt
nicotinamide phosphoribosyltransferase
chr4_+_140256449 2.677 Rcc2
regulator of chromosome condensation 2
chr2_+_51928350 2.641 NM_175238
Rif1
Rap1 interacting factor 1 homolog (yeast)
chr5_+_135526788 2.639


chr10_+_80291835 2.629


chr15_+_80453912 2.618 NM_010815
Grap2
GRB2-related adaptor protein 2
chr8_+_42416046 2.606 Pcm1
pericentriolar material 1
chr5_-_135095885 2.583


chrX_-_161764912 2.574 NM_183427
Glra2
glycine receptor, alpha 2 subunit
chr16_-_64786146 2.536 NM_028059
Zfp654
zinc finger protein 654
chr17_-_85461840 2.511 Prepl
prolyl endopeptidase-like
chr7_+_26958427 2.510 NM_010000
Cyp2b9
cytochrome P450, family 2, subfamily b, polypeptide 9
chr6_-_90612275 2.443 Iqsec1
IQ motif and Sec7 domain 1
chr2_+_102546576 2.441 NM_001077515
NM_011393
Slc1a2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr3_+_51298674 2.434 Rab33b
RAB33B, member of RAS oncogene family
chr5_-_135096084 2.419


chr19_-_4785312 2.389


chr13_-_94407548 2.373 Bhmt
betaine-homocysteine methyltransferase
chr16_-_55934909 2.371 NM_001159364
NM_001159365
NM_001159366
NM_028815
Cep97



centrosomal protein 97



chr16_-_88896693 2.356 NM_010676
Krtap8-2
keratin associated protein 8-2
chr18_+_34480612 2.351 Apc
adenomatosis polyposis coli
chr3_-_106592919 2.347 NM_007651
Cd53
CD53 antigen
chr19_+_29218114 2.333


chr9_-_70782366 2.332 Lipc
lipase, hepatic
chr3_+_95463691 2.313 Mcl1
myeloid cell leukemia sequence 1
chr17_+_48403658 2.281 NM_001033922
NM_001163795
NM_001163796
NM_172623
Treml4



triggering receptor expressed on myeloid cells-like 4



chr8_+_89240252 2.270 Lonp2
lon peptidase 2, peroxisomal
chr4_-_120642197 2.268 Smap2
stromal membrane-associated GTPase-activating protein 2
chr11_+_95610380 2.252 NM_201609
Zfp652
zinc finger protein 652
chr17_+_18024787 2.220 NM_008039
Fpr2
Fpr3
formyl peptide receptor 2
formyl peptide receptor 3
chr15_-_98373055 2.204 Ccnt1
cyclin T1
chr5_-_135096100 2.199 Eif4h
eukaryotic translation initiation factor 4H
chr19_+_5647822 2.194 Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr1_+_92509306 2.188 Cops8
COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
chr4_-_34754469 2.177 Zfp292
zinc finger protein 292
chr3_+_84668066 2.174 NM_001177774
Fbxw7
F-box and WD-40 domain protein 7
chr11_+_49933305 2.172 LOC552912
hypothetical LOC552912
chr13_+_105077914 2.163 NM_001081020
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr18_+_24796993 2.160 Elp2
elongation protein 2 homolog (S. cerevisiae)
chr14_-_122314994 2.158 NM_182806
Gpr18
G protein-coupled receptor 18
chr10_-_14438019 2.129 NM_029722
Gje1
gap junction protein, epsilon 1
chr17_-_32557807 2.120 Pglyrp2
peptidoglycan recognition protein 2
chr10_+_67498616 2.119 Rtkn2
rhotekin 2
chr9_-_62644026 2.118 Fem1b
feminization 1 homolog b (C. elegans)
chr3_-_20174589 2.116 NM_029706
Cpb1
carboxypeptidase B1 (tissue)
chr2_+_24817941 2.114 NM_026044
Wdr85
WD repeat domain 85
chr12_+_53800302 2.113 Akap6
A kinase (PRKA) anchor protein 6
chr6_+_123212124 2.086 NM_001163161
NM_010819
Clec4d

C-type lectin domain family 4, member d

chr8_+_97197870 2.086 Arl2bp
ADP-ribosylation factor-like 2 binding protein
chr2_-_83781362 2.075 NM_027964
Zswim2
zinc finger, SWIM domain containing 2
chr9_+_50924105 2.073 NM_019493
Btg4
B-cell translocation gene 4
chr2_-_7002344 2.058 NM_001110229
NM_001110230
NM_001160292
Celf2


CUGBP, Elav-like family member 2


chr6_+_123974775 2.048 NM_019917
Vmn2r26
vomeronasal 2, receptor 26
chr10_-_80555389 2.020 Creb3l3
cAMP responsive element binding protein 3-like 3
chr11_-_29501956 2.011



Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.