Motif ID: NR5A1,2.p2

Z-value: 3.359


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
Nr5a1 26423 nuclear receptor subfamily 5, group A, member 1
Nr5a2 26424 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr5a2chr1_-_1388568660.231.4e-03Click!
Nr5a1chr2_-_385698910.064.3e-01Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_37631532 56.937 Dlc1
deleted in liver cancer 1
chr18_-_10706693 49.186 NM_134130
Abhd3
abhydrolase domain containing 3
chr1_-_169323901 47.708 NM_025569
Mgst3
microsomal glutathione S-transferase 3
chr19_-_43598949 46.454 NM_010324
Got1
glutamate oxaloacetate transaminase 1, soluble
chr9_+_43893029 44.471 Usp2
ubiquitin specific peptidase 2
chr10_-_76175108 43.867 Col6a1
collagen, type VI, alpha 1
chr6_+_17257720 43.385 Cav1
caveolin 1, caveolae protein
chr13_+_21813912 40.978 NM_178200
Hist1h2bm
histone cluster 1, H2bm
chr11_-_4604308 39.417 NM_197979
Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr16_+_34995000 39.405 Mylk
myosin, light polypeptide kinase
chr15_+_78860043 37.230 H1f0
H1 histone family, member 0
chr13_-_21808011 36.832 NM_178199
Hist1h2bl
histone cluster 1, H2bl
chr7_-_116760069 36.642 St5
suppression of tumorigenicity 5
chr15_-_76881097 35.598 NM_013593
Mb
myoglobin
chr13_+_21845991 35.001 NM_178201
Hist1h2bn
histone cluster 1, H2bn
chr4_-_82151004 34.438 Nfib
nuclear factor I/B
chr6_+_17290478 34.205 Cav1
caveolin 1, caveolae protein
chr1_+_45401303 33.544 Col3a1
collagen, type III, alpha 1
chr13_+_22127689 32.912 NM_175665
Hist1h2bk
histone cluster 1, H2bk
chr8_+_47619706 32.240


chr15_+_78859949 31.679


chr11_+_94811409 31.276 Col1a1
collagen, type I, alpha 1
chr6_+_148303173 30.369 Rps4y2
ribosomal protein S4, Y-linked 2
chr19_-_7292086 29.503 NM_007750
Cox8a
cytochrome c oxidase, subunit VIIIa
chr13_+_22135065 29.005 NM_178198
Hist1h2bj
histone cluster 1, H2bj
chr19_-_7292057 28.934 Cox8a
cytochrome c oxidase, subunit VIIIa
chr15_+_81702875 28.905 NM_080633
LOC100504340
Aco2
hypothetical protein LOC100504340
aconitase 2, mitochondrial
chr7_-_74879894 28.863 Synm
synemin, intermediate filament protein
chr6_+_4483741 28.838 Col1a2
collagen, type I, alpha 2
chr4_-_82150687 27.715 Nfib
nuclear factor I/B
chr10_+_75398588 27.482 Chchd10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr4_-_82151590 27.472 Nfib
nuclear factor I/B
chr17_-_57199207 26.274 NM_025877
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr15_+_97942484 26.125 NM_021514
Pfkm
phosphofructokinase, muscle
chr9_-_30978164 25.926 Aplp2
amyloid beta (A4) precursor-like protein 2
chr2_-_180891448 25.492 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr19_-_7292009 25.129 Cox8a
cytochrome c oxidase, subunit VIIIa
chr2_+_155207542 24.521 Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr7_+_26102182 24.298 NM_001160400
Megf8
multiple EGF-like-domains 8
chr2_+_177853679 24.035 NM_001177789
NM_001177790
Phactr3

phosphatase and actin regulator 3

chr7_+_96781228 23.765 Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr14_+_120724380 23.685 Mbnl2
muscleblind-like 2
chr19_-_6982516 22.898 Prdx5
peroxiredoxin 5
chr13_-_92016479 22.841 NM_198415
Ckmt2
creatine kinase, mitochondrial 2
chr13_+_23838602 22.730 NM_175664
Hist1h2bb
histone cluster 1, H2bb
chrX_+_54032858 22.696 NM_001077362
Fhl1
four and a half LIM domains 1
chr4_-_82151180 22.605 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr16_-_84835213 22.518 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr9_-_66880619 22.335 Tpm1
tropomyosin 1, alpha
chr2_-_23904343 22.214 Hnmt
histamine N-methyltransferase
chr1_+_75542840 22.210 NM_009208
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr17_-_26005645 22.127 Fam195a
family with sequence similarity 195, member A
chr14_-_71029960 22.000 NM_013514
Epb4.9
erythrocyte protein band 4.9
chr6_+_4484651 21.974 Col1a2
collagen, type I, alpha 2
chr9_+_43892984 21.822 NM_198091
Usp2
ubiquitin specific peptidase 2
chr7_+_96781322 21.783 NM_181407
Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr7_-_110962416 21.698 NM_008220
NM_016956
Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr11_+_87861245 21.601 Srsf1
serine/arginine-rich splicing factor 1
chrX_+_54032914 21.250 Fhl1
four and a half LIM domains 1
chr7_+_31092787 21.244 Clip3
CAP-GLY domain containing linker protein 3
chr7_-_31839825 21.191 NM_052991
NM_194321
Fxyd1

FXYD domain-containing ion transport regulator 1

chr9_+_57758783 21.090 NM_001122873
NM_027086
Ubl7

ubiquitin-like 7 (bone marrow stromal cell-derived)

chr7_-_110962324 21.019 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr19_+_23239333 20.945 Klf9
Kruppel-like factor 9
chr12_+_103793130 20.850 NM_007693
Chga
chromogranin A
chr11_+_29618696 20.762 Rtn4
reticulon 4
chr2_-_73497987 20.588 Chn1
chimerin (chimaerin) 1
chr7_-_110976438 20.486 Hbb-b1
hemoglobin, beta adult major chain
chr6_+_90500848 20.457 Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr17_-_26005680 20.440 NM_026633
Fam195a
family with sequence similarity 195, member A
chr5_+_114615526 20.440 NM_133904
Acacb
acetyl-Coenzyme A carboxylase beta
chr6_+_90500855 20.283 Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr7_-_110976314 20.281 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr10_+_93661746 20.225 NM_025551
Ndufa12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr14_+_120724163 20.198 Mbnl2
muscleblind-like 2
chr6_+_90500776 20.175 NM_027406
Aldh1l1
aldehyde dehydrogenase 1 family, member L1
chrX_+_20265590 20.172 NM_011049
Cdk16
cyclin-dependent kinase 16
chr10_+_93661777 19.921 Ndufa12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr7_-_110976439 19.909 Hbb-b1
hemoglobin, beta adult major chain
chr9_-_54509453 19.877 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr2_+_121183509 19.726 Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr8_-_13494457 19.687 NM_019521
Gas6
growth arrest specific 6
chr4_-_60235470 19.465 NM_001134676
Mup8
major urinary protein 8
chr16_+_18777032 19.209 Cldn5
claudin 5
chr2_+_32483909 19.195 NM_001198792
Ak1
adenylate kinase 1
chr2_+_157387284 18.923 Nnat
neuronatin
chrX_-_91787372 18.673 NM_019791
Maged1
melanoma antigen, family D, 1
chr9_-_54509658 18.668 NM_053178
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr13_-_23635220 18.604 NM_178197
Hist1h2bh
histone cluster 1, H2bh
chr19_-_40588235 18.511 Sorbs1
sorbin and SH3 domain containing 1
chr11_-_5703677 18.494 Pgam2
phosphoglycerate mutase 2
chr19_-_40588193 18.475 Sorbs1
sorbin and SH3 domain containing 1
chr2_+_121184334 18.457 NM_009897
Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr1_+_36748379 18.186 Cox5b
cytochrome c oxidase, subunit Vb
chrX_-_91787338 17.913 Maged1
melanoma antigen, family D, 1
chrX_-_91787351 17.910 Maged1
melanoma antigen, family D, 1
chr2_-_181049204 17.856 NM_009133
Stmn3
stathmin-like 3
chr8_+_12915892 17.695 NM_178076
Mcf2l
mcf.2 transforming sequence-like
chr15_+_68758773 17.551 NM_010158
Khdrbs3
KH domain containing, RNA binding, signal transduction associated 3
chrX_-_91787353 17.364 Maged1
melanoma antigen, family D, 1
chr7_-_20284500 17.289 NM_009696
Apoe
apolipoprotein E
chr18_+_82723854 17.156 NM_001025251
NM_001025255
NM_001025256
NM_001025258
NM_001025259
NM_001025254
Mbp





myelin basic protein





chrX_-_91787317 17.152 Maged1
melanoma antigen, family D, 1
chr10_-_83903215 17.119 NM_001004363
Nuak1
NUAK family, SNF1-like kinase, 1
chr1_-_79855177 16.969 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr11_-_116515602 16.908 NM_030206
Cygb
cytoglobin
chr11_-_118181503 16.834 Timp2
tissue inhibitor of metalloproteinase 2
chr7_-_135349828 16.702 NM_009943
Cox6a2
cytochrome c oxidase, subunit VI a, polypeptide 2
chr9_-_107571294 16.692 Slc38a3
solute carrier family 38, member 3
chr13_-_23666058 16.595 NM_178195
Hist1h2bf
histone cluster 1, H2bf
chr1_-_79855229 16.591 NM_009255
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr18_+_82723907 16.572 Mbp
myelin basic protein
chr11_+_6191708 16.509 Ogdh
oxoglutarate dehydrogenase (lipoamide)
chr9_-_45744036 16.479 NM_011526
Tagln
transgelin
chr12_+_73885063 16.384 Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
chr3_-_126701367 16.257 NM_178655
Ank2
ankyrin 2, brain
chr4_-_82151657 16.174 Nfib
nuclear factor I/B
chr18_+_44493726 16.153 NM_001033621
Myot
myotilin
chr1_+_51346108 16.125 Sdpr
serum deprivation response
chr1_-_79855209 16.041 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr3_+_32635988 16.016 Ndufb5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5
chr11_+_6191622 15.935 Ogdh
oxoglutarate dehydrogenase (lipoamide)
chr19_-_38199036 15.930 Rbp4
retinol binding protein 4, plasma
chr1_+_36748331 15.842 NM_009942
Cox5b
cytochrome c oxidase, subunit Vb
chr15_-_44619541 15.794 NM_001032727
NM_176998
Sybu

syntabulin (syntaxin-interacting)

chr16_+_18776936 15.782 NM_013805
Cldn5
claudin 5
chr8_-_107995252 15.760 Tppp3
tubulin polymerization-promoting protein family member 3
chr5_-_134932407 15.711 NM_001081462
NM_001081463
NM_001081464
NM_001081466
NM_001081467
NM_001081468
NM_001081469
NM_001081470
NM_020331
Gtf2ird1








general transcription factor II I repeat domain-containing 1








chr3_-_126646303 15.703 NM_001034168
Ank2
ankyrin 2, brain
chr3_+_90346956 15.687 S100a16
S100 calcium binding protein A16
chr7_+_19996439 15.621 NM_007710
Ckm
creatine kinase, muscle
chr8_+_11448095 15.569 Col4a2
collagen, type IV, alpha 2
chr11_-_116515361 15.520 Cygb
cytoglobin
chr7_-_133591146 15.495 Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr8_-_11212651 15.445 Col4a1
collagen, type IV, alpha 1
chr6_-_136824323 15.424 NM_008597
Mgp
matrix Gla protein
chr6_+_4471231 15.402 Col1a2
collagen, type I, alpha 2
chr11_+_67013553 15.374 NM_030679
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr16_+_18776955 15.367 Cldn5
claudin 5
chr3_-_129035406 15.353 NM_007934
Enpep
glutamyl aminopeptidase
chr13_+_83663817 15.327 Mef2c
myocyte enhancer factor 2C
chr18_+_78012690 15.303 Atp5a1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
chr8_-_107995282 15.206 NM_026481
Tppp3
tubulin polymerization-promoting protein family member 3
chr1_+_74760129 15.109 NM_024264
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr2_+_174170886 14.947 Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr1_+_51346086 14.929 Sdpr
serum deprivation response
chr2_-_130110142 14.928 NM_130884
Idh3b
isocitrate dehydrogenase 3 (NAD+) beta
chr15_+_12251184 14.922 Golph3
golgi phosphoprotein 3
chr18_+_45428413 14.859 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr19_-_40588297 14.844 NM_009166
Sorbs1
sorbin and SH3 domain containing 1
chr5_+_91946651 14.799 NM_145562
Parm1
prostate androgen-regulated mucin-like protein 1
chrX_+_133357268 14.791 NM_011123
Plp1
proteolipid protein (myelin) 1
chr5_-_104542751 14.713 Sparcl1
SPARC-like 1
chr10_+_81022304 14.702 NM_010347
Aes
amino-terminal enhancer of split
chr19_-_40588219 14.672 NM_178362
Sorbs1
sorbin and SH3 domain containing 1
chr1_+_45401659 14.619 Col3a1
collagen, type III, alpha 1
chr8_+_47576483 14.516 Acsl1
acyl-CoA synthetase long-chain family member 1
chr1_-_71632834 14.444 Fn1
fibronectin 1
chr13_-_86186317 14.422 NM_007749
Cox7c
cytochrome c oxidase, subunit VIIc
chr16_+_5884885 14.402 NM_021477
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_66221851 14.371 NM_001039934
NM_008632
Mtap2

microtubule-associated protein 2

chr12_+_62625477 14.325 NM_178714
Lrfn5
leucine rich repeat and fibronectin type III domain containing 5
chr6_-_136824217 14.319 Mgp
matrix Gla protein
chr16_+_5885447 14.311 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_74760162 14.302 Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr7_-_31699850 14.242 NM_010758
Mag
myelin-associated glycoprotein
chr5_+_114222723 14.182 NM_025526
Iscu
IscU iron-sulfur cluster scaffold homolog (E. coli)
chr13_-_64468380 14.172 Ctsl
cathepsin L
chr13_+_23663264 14.148 NM_178196
Hist1h2bg
histone cluster 1, H2bg
chr9_-_107571304 14.123 Slc38a3
solute carrier family 38, member 3
chr10_+_97028456 14.118 Lum
lumican
chr11_-_73137838 14.025 Aspa
aspartoacylase
chr4_+_99602038 13.999 NM_028132
Pgm2
phosphoglucomutase 2
chr14_-_21437545 13.968 NM_030180
Usp54
ubiquitin specific peptidase 54
chr7_-_133606617 13.959 Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr14_+_84933363 13.953 Pcdh17
protocadherin 17
chr17_+_24544500 13.923 Abca3
ATP-binding cassette, sub-family A (ABC1), member 3
chr18_+_82723920 13.835 Mbp
myelin basic protein
chr6_-_136824277 13.828 Mgp
matrix Gla protein
chr4_-_104782337 13.800 Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr19_+_57685498 13.772 NM_181415
Atrnl1
attractin like 1
chr5_-_104542729 13.754 Sparcl1
SPARC-like 1
chr2_+_138104219 13.753 NM_145534
Btbd3
BTB (POZ) domain containing 3
chr9_+_43901941 13.738 Usp2
ubiquitin specific peptidase 2
chr18_+_37979242 13.703 Pcdhgc5
protocadherin gamma subfamily C, 5
chr12_+_91570569 13.598 Nrxn3
neurexin III
chr1_+_164569335 13.544 Myoc
myocilin
chr5_-_17355533 13.501 NM_001159556
NM_001159557
Cd36

CD36 antigen

chr9_+_46037941 13.451


chr9_+_54434140 13.447 NM_029573
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr3_+_32635972 13.379 NM_025316
Ndufb5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5
chrX_+_154137193 13.373 Smpx
small muscle protein, X-linked
chrX_+_162782484 13.357 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
Gpm6b





glycoprotein m6b





chrX_+_154137114 13.336 Smpx
small muscle protein, X-linked
chr1_-_166388431 13.268 NM_009721
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chrX_+_91612443 13.134 NM_026673
Apoo
apolipoprotein O
chr16_-_91931806 13.117 NM_138597
Atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chrX_+_154137049 13.104 NM_025357
Smpx
small muscle protein, X-linked
chr11_-_95936914 13.083 NM_001161419
NM_007506
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr2_+_152561983 13.078 NM_010495
Id1
inhibitor of DNA binding 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.67 2.78e-25 GO:0006091 generation of precursor metabolites and energy
1.52 2.54e-20 GO:0051179 localization
1.56 1.36e-18 GO:0006810 transport
1.54 5.56e-18 GO:0051234 establishment of localization
4.00 8.77e-14 GO:0022900 electron transport chain
1.97 2.46e-13 GO:0055114 oxidation-reduction process
1.21 7.22e-10 GO:0008152 metabolic process
3.41 5.70e-09 GO:0015980 energy derivation by oxidation of organic compounds
1.53 7.66e-09 GO:0044281 small molecule metabolic process
4.30 1.07e-08 GO:0045333 cellular respiration
1.75 4.02e-08 GO:0006629 lipid metabolic process
2.26 7.67e-08 GO:0032787 monocarboxylic acid metabolic process
1.40 8.22e-08 GO:0048731 system development
6.80 1.91e-07 GO:0046356 acetyl-CoA catabolic process
2.45 1.95e-07 GO:0006631 fatty acid metabolic process
1.46 2.93e-07 GO:0065008 regulation of biological quality
1.20 5.95e-07 GO:0044237 cellular metabolic process
1.40 6.63e-07 GO:0048523 negative regulation of cellular process
1.81 6.68e-07 GO:0019752 carboxylic acid metabolic process
1.81 6.68e-07 GO:0043436 oxoacid metabolic process
1.34 7.26e-07 GO:0016043 cellular component organization
1.54 1.25e-06 GO:0009056 catabolic process
6.67 1.31e-06 GO:0006099 tricarboxylic acid cycle
1.79 1.37e-06 GO:0006082 organic acid metabolic process
1.35 1.46e-06 GO:0048856 anatomical structure development
2.94 1.58e-06 GO:0003012 muscle system process
1.78 1.68e-06 GO:0042180 cellular ketone metabolic process
1.37 3.48e-06 GO:0048519 negative regulation of biological process
8.06 3.49e-06 GO:0015985 energy coupled proton transport, down electrochemical gradient
8.06 3.49e-06 GO:0015986 ATP synthesis coupled proton transport
1.78 4.34e-06 GO:0048878 chemical homeostasis
3.03 5.63e-06 GO:0006936 muscle contraction
4.90 5.76e-06 GO:0006096 glycolysis
5.44 6.00e-06 GO:0009109 coenzyme catabolic process
1.78 8.15e-06 GO:0044255 cellular lipid metabolic process
2.63 8.96e-06 GO:0019216 regulation of lipid metabolic process
1.30 9.61e-06 GO:0032502 developmental process
1.31 9.64e-06 GO:0007275 multicellular organismal development
4.52 1.14e-05 GO:0006084 acetyl-CoA metabolic process
1.30 1.77e-05 GO:0071840 cellular component organization or biogenesis
2.67 2.04e-05 GO:0007005 mitochondrion organization
1.61 2.29e-05 GO:0042592 homeostatic process
2.96 3.12e-05 GO:0006006 glucose metabolic process
2.22 7.72e-05 GO:0051129 negative regulation of cellular component organization
3.68 7.84e-05 GO:0006754 ATP biosynthetic process
5.33 9.03e-05 GO:0009060 aerobic respiration
3.41 1.01e-04 GO:0051494 negative regulation of cytoskeleton organization
4.62 1.38e-04 GO:0051187 cofactor catabolic process
1.49 1.41e-04 GO:0007399 nervous system development
1.58 2.14e-04 GO:0051128 regulation of cellular component organization
1.33 4.69e-04 GO:0071842 cellular component organization at cellular level
3.27 4.82e-04 GO:0009206 purine ribonucleoside triphosphate biosynthetic process
1.55 5.21e-04 GO:0022607 cellular component assembly
1.57 5.37e-04 GO:0006811 ion transport
3.22 6.57e-04 GO:0009145 purine nucleoside triphosphate biosynthetic process
3.22 6.57e-04 GO:0009201 ribonucleoside triphosphate biosynthetic process
3.22 6.57e-04 GO:0044275 cellular carbohydrate catabolic process
1.50 7.16e-04 GO:0051641 cellular localization
2.34 7.40e-04 GO:0060537 muscle tissue development
3.95 9.02e-04 GO:0043242 negative regulation of protein complex disassembly
3.13 1.19e-03 GO:0009142 nucleoside triphosphate biosynthetic process
3.55 1.35e-03 GO:0019320 hexose catabolic process
1.75 1.53e-03 GO:0055082 cellular chemical homeostasis
1.82 1.62e-03 GO:0006066 alcohol metabolic process
2.85 1.74e-03 GO:0010565 regulation of cellular ketone metabolic process
1.68 1.92e-03 GO:0019725 cellular homeostasis
1.75 2.10e-03 GO:0006873 cellular ion homeostasis
3.91 2.41e-03 GO:0043648 dicarboxylic acid metabolic process
3.57 2.42e-03 GO:0006007 glucose catabolic process
3.41 2.70e-03 GO:0046365 monosaccharide catabolic process
1.71 2.80e-03 GO:0050801 ion homeostasis
2.78 2.83e-03 GO:0016052 carbohydrate catabolic process
2.40 3.07e-03 GO:0019318 hexose metabolic process
2.83 3.11e-03 GO:0009152 purine ribonucleotide biosynthetic process
2.55 3.29e-03 GO:0010639 negative regulation of organelle organization
1.30 3.71e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.52 3.97e-03 GO:0022008 neurogenesis
1.72 4.01e-03 GO:0044283 small molecule biosynthetic process
2.30 4.35e-03 GO:0010876 lipid localization
3.43 4.87e-03 GO:0043244 regulation of protein complex disassembly
2.27 6.09e-03 GO:0014706 striated muscle tissue development
1.26 6.23e-03 GO:0048518 positive regulation of biological process
1.37 6.56e-03 GO:0065009 regulation of molecular function
1.67 7.43e-03 GO:0044282 small molecule catabolic process
2.42 7.45e-03 GO:0006164 purine nucleotide biosynthetic process
2.98 9.03e-03 GO:0046164 alcohol catabolic process
2.67 1.01e-02 GO:0009260 ribonucleotide biosynthetic process
2.31 1.07e-02 GO:0006869 lipid transport
2.34 1.08e-02 GO:0072522 purine-containing compound biosynthetic process
4.13 1.27e-02 GO:0022904 respiratory electron transport chain
3.23 1.28e-02 GO:0006839 mitochondrial transport
5.71 1.39e-02 GO:0006103 2-oxoglutarate metabolic process
1.44 1.52e-02 GO:0044085 cellular component biogenesis
1.53 1.60e-02 GO:0055085 transmembrane transport
1.43 1.61e-02 GO:0044248 cellular catabolic process
1.82 1.62e-02 GO:0034220 ion transmembrane transport
2.98 1.63e-02 GO:0019217 regulation of fatty acid metabolic process
2.13 1.67e-02 GO:0005996 monosaccharide metabolic process
1.57 2.06e-02 GO:0046907 intracellular transport
1.57 2.09e-02 GO:0006812 cation transport
1.14 2.52e-02 GO:0044238 primary metabolic process
8.16 2.78e-02 GO:0010873 positive regulation of cholesterol esterification
1.46 3.02e-02 GO:0048468 cell development
1.95 3.59e-02 GO:0051186 cofactor metabolic process
1.35 3.70e-02 GO:0009653 anatomical structure morphogenesis
1.56 3.80e-02 GO:0065003 macromolecular complex assembly
1.46 3.84e-02 GO:0051649 establishment of localization in cell
1.38 3.90e-02 GO:0050790 regulation of catalytic activity
2.07 4.21e-02 GO:0042391 regulation of membrane potential
1.53 4.39e-02 GO:0043933 macromolecular complex subunit organization
1.34 4.41e-02 GO:0023051 regulation of signaling
3.75 4.50e-02 GO:0046320 regulation of fatty acid oxidation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.58 2.19e-54 GO:0044444 cytoplasmic part
1.41 1.34e-50 GO:0005737 cytoplasm
2.21 1.40e-44 GO:0005739 mitochondrion
1.26 5.15e-35 GO:0044424 intracellular part
1.25 1.51e-34 GO:0005622 intracellular
2.84 4.78e-33 GO:0044429 mitochondrial part
3.07 8.51e-31 GO:0031966 mitochondrial membrane
2.99 7.14e-30 GO:0005740 mitochondrial envelope
3.31 1.88e-28 GO:0005743 mitochondrial inner membrane
1.27 1.09e-26 GO:0043229 intracellular organelle
1.26 1.54e-26 GO:0043226 organelle
3.14 3.44e-26 GO:0019866 organelle inner membrane
2.39 1.05e-22 GO:0031967 organelle envelope
4.90 1.33e-22 GO:0044455 mitochondrial membrane part
2.36 5.40e-22 GO:0031975 envelope
1.93 1.61e-21 GO:0031090 organelle membrane
1.25 5.47e-19 GO:0043231 intracellular membrane-bounded organelle
1.25 7.58e-19 GO:0043227 membrane-bounded organelle
6.06 1.24e-18 GO:0070469 respiratory chain
1.36 2.30e-14 GO:0044422 organelle part
1.35 1.43e-13 GO:0044446 intracellular organelle part
5.67 1.49e-13 GO:0005746 mitochondrial respiratory chain
1.09 6.03e-11 GO:0005623 cell
1.09 6.03e-11 GO:0044464 cell part
5.82 1.10e-10 GO:0005747 mitochondrial respiratory chain complex I
5.82 1.10e-10 GO:0030964 NADH dehydrogenase complex
5.82 1.10e-10 GO:0045271 respiratory chain complex I
1.66 1.34e-10 GO:0000267 cell fraction
1.66 1.09e-09 GO:0042995 cell projection
1.34 1.41e-09 GO:0032991 macromolecular complex
1.71 2.45e-09 GO:0005626 insoluble fraction
1.71 6.71e-09 GO:0005624 membrane fraction
1.36 1.91e-08 GO:0043234 protein complex
1.87 3.20e-08 GO:0043005 neuron projection
8.73 8.57e-08 GO:0005753 mitochondrial proton-transporting ATP synthase complex
7.62 2.77e-07 GO:0045259 proton-transporting ATP synthase complex
2.92 2.96e-07 GO:0043292 contractile fiber
2.06 6.92e-07 GO:0044297 cell body
2.07 1.12e-06 GO:0043025 neuronal cell body
2.92 1.32e-06 GO:0030016 myofibril
1.27 1.80e-06 GO:0071944 cell periphery
1.40 3.81e-06 GO:0044459 plasma membrane part
1.44 7.55e-06 GO:0005856 cytoskeleton
1.65 8.22e-06 GO:0005615 extracellular space
3.00 1.53e-05 GO:0030017 sarcomere
1.43 2.00e-05 GO:0005829 cytosol
2.81 2.87e-05 GO:0044449 contractile fiber part
1.25 3.13e-05 GO:0005886 plasma membrane
1.52 4.46e-05 GO:0044421 extracellular region part
1.76 4.57e-05 GO:0045202 synapse
1.81 6.64e-05 GO:0044463 cell projection part
1.30 8.23e-05 GO:0043228 non-membrane-bounded organelle
1.30 8.23e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.49 9.11e-05 GO:0005783 endoplasmic reticulum
2.37 1.53e-04 GO:0005759 mitochondrial matrix
1.13 2.45e-04 GO:0016020 membrane
1.93 3.80e-04 GO:0015629 actin cytoskeleton
1.90 6.10e-04 GO:0030425 dendrite
2.03 8.75e-04 GO:0016323 basolateral plasma membrane
1.94 1.19e-03 GO:0045177 apical part of cell
1.85 1.22e-03 GO:0048471 perinuclear region of cytoplasm
2.75 1.30e-03 GO:0042383 sarcolemma
5.71 2.00e-03 GO:0005865 striated muscle thin filament
3.99 2.86e-03 GO:0044304 main axon
1.79 3.18e-03 GO:0042598 vesicular fraction
1.87 3.83e-03 GO:0030424 axon
1.53 5.64e-03 GO:0030054 cell junction
9.52 6.00e-03 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
1.29 7.41e-03 GO:0005576 extracellular region
1.42 7.97e-03 GO:0044430 cytoskeletal part
1.72 1.01e-02 GO:0044456 synapse part
2.25 1.06e-02 GO:0031301 integral to organelle membrane
1.74 1.19e-02 GO:0005792 microsome
7.14 1.46e-02 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
4.33 1.48e-02 GO:0034364 high-density lipoprotein particle
2.16 1.64e-02 GO:0033267 axon part
1.39 1.97e-02 GO:0005794 Golgi apparatus
5.08 2.25e-02 GO:0031672 A band
2.36 2.30e-02 GO:0005741 mitochondrial outer membrane
3.35 2.70e-02 GO:0016469 proton-transporting two-sector ATPase complex
2.27 3.21e-02 GO:0019898 extrinsic to membrane
7.93 3.29e-02 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
2.05 3.68e-02 GO:0031300 intrinsic to organelle membrane
2.41 4.73e-02 GO:0014069 postsynaptic density

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.34 1.80e-19 GO:0005515 protein binding
1.19 1.01e-18 GO:0005488 binding
2.20 8.99e-14 GO:0008092 cytoskeletal protein binding
1.27 2.51e-10 GO:0003824 catalytic activity
1.80 1.40e-08 GO:0016491 oxidoreductase activity
2.10 1.34e-07 GO:0032403 protein complex binding
2.13 1.45e-06 GO:0003779 actin binding
3.30 9.10e-06 GO:0015078 hydrogen ion transmembrane transporter activity
1.52 1.75e-05 GO:0005215 transporter activity
1.58 1.90e-05 GO:0022892 substrate-specific transporter activity
2.13 2.28e-05 GO:0048037 cofactor binding
2.28 3.97e-05 GO:0022890 inorganic cation transmembrane transporter activity
1.75 6.13e-05 GO:0005509 calcium ion binding
1.54 1.81e-04 GO:0022857 transmembrane transporter activity
1.83 1.91e-04 GO:0005198 structural molecule activity
1.57 2.43e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.60 4.43e-04 GO:0015075 ion transmembrane transporter activity
5.51 5.08e-04 GO:0003954 NADH dehydrogenase activity
1.50 1.05e-03 GO:0019899 enzyme binding
2.27 2.38e-03 GO:0015077 monovalent inorganic cation transmembrane transporter activity
5.29 2.83e-03 GO:0008137 NADH dehydrogenase (ubiquinone) activity
5.29 2.83e-03 GO:0050136 NADH dehydrogenase (quinone) activity
1.63 5.55e-03 GO:0008324 cation transmembrane transporter activity
3.24 6.38e-03 GO:0051287 NAD binding
2.45 7.08e-03 GO:0019838 growth factor binding
2.06 7.63e-03 GO:0050662 coenzyme binding
1.68 8.80e-03 GO:0008289 lipid binding
4.76 9.80e-03 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
1.99 1.12e-02 GO:0061134 peptidase regulator activity
1.46 1.55e-02 GO:0042802 identical protein binding
1.56 2.36e-02 GO:0019904 protein domain specific binding
1.20 2.49e-02 GO:0046872 metal ion binding
1.19 3.45e-02 GO:0043169 cation binding
2.02 3.46e-02 GO:0061135 endopeptidase regulator activity
1.19 3.77e-02 GO:0043167 ion binding
1.42 3.90e-02 GO:0030234 enzyme regulator activity
3.88 3.94e-02 GO:0016877 ligase activity, forming carbon-sulfur bonds
1.77 4.40e-02 GO:0004857 enzyme inhibitor activity