Motif ID: RORA.p2

Z-value: 0.899


Transcription factors associated with RORA.p2:

Gene SymbolEntrez IDGene Name
Rora 19883 RAR-related orphan receptor alpha

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rorachr9_+_685015510.602.2e-19Click!


Activity profile for motif RORA.p2.

activity profile for motif RORA.p2


Sorted Z-values histogram for motif RORA.p2

Sorted Z-values for motif RORA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RORA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_6384413 26.418 NM_011224
Pygm
muscle glycogen phosphorylase
chr9_-_53822931 26.393 Elmod1
ELMO domain containing 1
chr9_-_53823107 24.916 NM_177769
Elmod1
ELMO domain containing 1
chr7_+_52960585 24.414 NM_016974
Dbp
D site albumin promoter binding protein
chr7_+_52960702 20.601 Dbp
D site albumin promoter binding protein
chr11_-_69418965 16.018 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr18_+_23468585 12.434 Dtna
dystrobrevin alpha
chr9_-_86589782 11.179 NM_008615
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr12_-_82434150 10.884 NM_001167920
NM_080440
Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr14_-_56143799 10.706 NM_001136074
Nrl
neural retina leucine zipper gene
chr15_-_7348093 10.632 Egflam
EGF-like, fibronectin type III and laminin G domains
chr15_-_7348393 9.954 Egflam
EGF-like, fibronectin type III and laminin G domains
chr7_+_53693190 9.210 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr8_-_3625251 7.986 NM_008790
Pcp2
Purkinje cell protein 2 (L7)
chrX_-_99447501 7.907 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr2_+_90725895 7.492 NM_026161
C1qtnf4
C1q and tumor necrosis factor related protein 4
chr10_+_56097078 7.456 NM_010288
Gja1
gap junction protein, alpha 1
chr6_+_113408477 7.296 NM_145826
Il17re
interleukin 17 receptor E
chr15_-_7348290 6.858 NM_178748
Egflam
EGF-like, fibronectin type III and laminin G domains
chr10_+_5151833 6.809 NM_001079686
Syne1
synaptic nuclear envelope 1
chr8_-_3624988 6.606 NM_001129804
Pcp2
Purkinje cell protein 2 (L7)
chr1_+_74589461 6.062 NM_001081456
Plcd4
phospholipase C, delta 4
chr7_+_120350963 5.952 NM_007489
Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr6_+_104443037 5.917 NM_017383
Cntn6
contactin 6
chr7_+_120351012 5.643 Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr10_+_79630579 5.386 NM_007705
Cirbp
cold inducible RNA binding protein
chr15_+_99532787 5.319 Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr3_+_146067763 5.301 Ssx2ip
synovial sarcoma, X breakpoint 2 interacting protein
chr6_+_90424727 4.820 Klf15
Kruppel-like factor 15
chr15_+_99532698 4.702 NM_031842
Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr12_+_84861415 4.699 NM_030246
Dcaf4
DDB1 and CUL4 associated factor 4
chr6_+_113408650 4.680 NM_001034029
NM_001034031
Il17re

interleukin 17 receptor E

chr6_-_88824037 4.561 NM_176973
Podxl2
podocalyxin-like 2
chr17_+_25023618 4.260 NM_001163750
NM_001163751
Spsb3

splA/ryanodine receptor domain and SOCS box containing 3

chr5_+_144861227 4.219 NM_001081109
Lmtk2
lemur tyrosine kinase 2
chr9_+_43915391 3.788 NM_001190319
C1qtnf5
C1q and tumor necrosis factor related protein 5
chr12_+_118754951 3.451 NM_175930
Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr19_+_23761879 3.418 NM_028208
Ptar1
protein prenyltransferase alpha subunit repeat containing 1
chr11_+_3414884 3.349 Selm
selenoprotein M
chr7_-_35437859 3.291 NM_146188
Kctd15
potassium channel tetramerisation domain containing 15
chr3_-_107734481 3.290 NM_026672
Gstm7
glutathione S-transferase, mu 7
chr15_-_74583382 3.269 NM_011838
Lynx1
Ly6/neurotoxin 1
chr3_+_89195758 3.164


chr7_+_133416177 2.989 Sbk1
SH3-binding kinase 1
chr8_-_3625510 2.915 NM_001129803
Pcp2
Purkinje cell protein 2 (L7)
chr1_-_182123596 2.874 NM_001163290
Adck3
aarF domain containing kinase 3
chr14_+_37881214 2.765 NM_173418
Lrit2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr6_+_4471231 2.696 Col1a2
collagen, type I, alpha 2
chr6_-_29330414 2.658 NM_007538
Opn1sw
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
chr7_+_96781322 2.614 NM_181407
Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr14_+_21493519 2.544 NM_001168273
NM_172596
Sec24c

Sec24 related gene family, member C (S. cerevisiae)

chr3_+_67868723 2.440 NM_001113420
NM_001113421
Schip1

schwannomin interacting protein 1

chr16_+_41533317 2.422 NM_175548
Lsamp
limbic system-associated membrane protein
chr11_+_121296252 2.339 NM_001038699
NM_022014
Fn3k

fructosamine 3 kinase

chr17_+_24869629 2.288 NM_025425
Rpl3l
ribosomal protein L3-like
chr17_-_79135885 2.243 NM_011500
Strn
striatin, calmodulin binding protein
chr11_-_20729367 2.029 1110067D22Rik
RIKEN cDNA 1110067D22 gene
chr9_+_20673178 1.971 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr12_-_16596573 1.939 NM_001130412
NM_015763
NM_172950
Lpin1


lipin 1


chr6_+_34426352 1.931 NM_007563
Bpgm
2,3-bisphosphoglycerate mutase
chr11_-_99146520 1.914 NM_029393
Krt24
keratin 24
chr3_+_137530638 1.860 NM_001033155
Dnajb14
DnaJ (Hsp40) homolog, subfamily B, member 14
chr12_+_53955707 1.762 Akap6
A kinase (PRKA) anchor protein 6
chr11_-_116060026 1.499 Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr17_-_24135049 1.478 NM_133731
Prss22
protease, serine, 22
chr9_-_54407955 1.451 Cib2
calcium and integrin binding family member 2
chr8_+_113618490 1.444 Pdpr
pyruvate dehydrogenase phosphatase regulatory subunit
chrX_+_150158113 1.440 2210013O21Rik
RIKEN cDNA 2210013O21 gene
chr1_+_53370483 1.417 NM_028091
Osgepl1
O-sialoglycoprotein endopeptidase-like 1
chr2_+_48805027 1.399 NM_029924
Mbd5
methyl-CpG binding domain protein 5
chr12_-_16596567 1.394 Lpin1
lipin 1
chr9_+_43915327 1.360 NM_001040631
NM_001040632
C1qtnf5

C1q and tumor necrosis factor related protein 5

chrX_-_26129763 1.309 NM_001162364
Gm14525
predicted gene 14525
chrX_-_24728580 1.309 NM_001040669
Gm5169
predicted gene 5169
chr18_-_68459753 1.296 4933403F05Rik
RIKEN cDNA 4933403F05 gene
chr14_+_56194510 1.292 NM_026808
Fitm1
fat storage-inducing transmembrane protein 1
chr6_+_124948627 1.280 NM_001145926
C530028O21Rik
RIKEN cDNA C530028O21 gene
chr6_+_48504791 1.277 NM_001110160
NM_177736
Lrrc61

leucine rich repeat containing 61

chr11_+_52202137 1.244 Vdac1
voltage-dependent anion channel 1
chr11_-_115489392 1.202 NM_026071
Slc25a19
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
chr17_+_33775000 1.174 NM_001002842
Pram1
PML-RAR alpha-regulated adaptor molecule 1
chr17_+_23737822 1.156 NM_001033425
Zscan10
zinc finger and SCAN domain containing 10
chr3_-_157587998 1.084 NM_145953
Cth
cystathionase (cystathionine gamma-lyase)
chr9_+_75289299 1.073 NM_001039522
Leo1
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr4_-_138375124 1.068 NM_011110
Pla2g5
phospholipase A2, group V
chr1_+_20720985 1.038 NM_010552
Il17a
interleukin 17A
chr12_+_80309899 0.993 NM_030017
Rdh12
retinol dehydrogenase 12
chrX_-_26362794 0.975 NM_001104946
NM_001114754
Gm2012
Gm6121
predicted gene 2012
predicted gene 6121
chr9_+_77602582 0.957 NM_010295
Gclc
glutamate-cysteine ligase, catalytic subunit
chr9_+_20673069 0.947 NM_175687
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr7_-_7162599 0.858 NM_145577
Zfp772
zinc finger protein 772
chr11_-_97011025 0.855 NM_198100
Tbkbp1
TBK1 binding protein 1
chr3_+_146067605 0.855 NM_138744
Ssx2ip
synovial sarcoma, X breakpoint 2 interacting protein
chr10_-_120335907 0.834 NM_177092
Msrb3
methionine sulfoxide reductase B3
chr2_+_29821079 0.816 NM_001076554
NM_001177667
NM_001177668
Spna2


spectrin alpha 2


chr18_+_85104396 0.807 NM_015798
Fbxo15
F-box protein 15
chr17_+_88071837 0.728 NM_008628
Msh2
mutS homolog 2 (E. coli)
chr2_+_119851954 0.722 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr14_-_51766415 0.714 NM_011271
Rnase1
ribonuclease, RNase A family, 1 (pancreatic)
chrX_-_26904190 0.698 NM_001109969
NM_001099919
NM_001102678
NM_001109970
NM_001110250
NM_001100610
NM_001099347
Gm10058
Gm10147
Gm10096
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_-_24498453 0.698 NM_001109969
NM_001099919
NM_001102678
NM_001109970
NM_001110250
NM_001100610
NM_001099347
Gm10058
Gm10147
Gm10096
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_+_29130521 0.674 NM_001109969
NM_001099919
NM_001102678
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
Gm10058
Gm10147
Gm10096
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chr10_+_77079550 0.668


chrX_-_27251094 0.658 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_-_28258880 0.658 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_-_26822007 0.646 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_-_27912080 0.646 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chr6_+_90554873 0.617 NM_027868
Slc41a3
solute carrier family 41, member 3
chrX_-_29947647 0.616 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_-_27597810 0.616 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_+_29483950 0.606 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_+_32944181 0.605 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chrX_+_32607378 0.605 NM_001109969
NM_001099919
NM_001102678
NM_001100609
NM_001109970
NM_001110250
NM_001099325
NM_001100610
NM_001099347
NM_009529
Gm10058
Gm10147
Gm10096
Gm10487
Gm10486
Gm14819
Gm10488
Gm14632
Gm10230
Gm4836
predicted gene 10058
predicted gene 10147
predicted gene 10096
predicted gene 10487
predicted gene 10486
predicted gene 14819
predicted gene 10488
predicted gene 14632
predicted gene 10230
predicted gene 4836
chr7_+_127883556 0.605 Vwa3a
von Willebrand factor A domain containing 3A
chr17_-_31774075 0.596 NM_178224
NM_144855
Cbs

cystathionine beta-synthase

chr15_-_97561769 0.530 NM_001168693
Endou
endonuclease, polyU-specific
chr17_+_72022598 0.518 NM_177087
Fam179a
family with sequence similarity 179, member A
chr9_+_77602377 0.517 Gclc
glutamate-cysteine ligase, catalytic subunit
chr4_-_82666973 0.513 NM_177863
Frem1
Fras1 related extracellular matrix protein 1
chr17_+_13200673 0.495 NM_013671
Sod2
superoxide dismutase 2, mitochondrial
chr3_-_72860864 0.476 NM_198864
Slitrk3
SLIT and NTRK-like family, member 3
chr11_+_109405024 0.473 NM_001166177
Arsg
arylsulfatase G
chrX_-_24352289 0.466 NM_001081657
Gm5935
predicted gene 5935
chr14_-_55482884 0.407 NM_001177705
Homez
homeodomain leucine zipper-encoding gene
chr6_+_34362333 0.390 NM_009731
Akr1b7
aldo-keto reductase family 1, member B7
chr11_-_78059124 0.389 NM_009297
Supt6h
suppressor of Ty 6 homolog (S. cerevisiae)
chr15_-_77473707 0.375 NM_001143686
Apol11b
apolipoprotein L 11b
chr13_-_21842373 0.359 NM_178211
Hist1h4k
histone cluster 1, H4k
chrX_+_34971918 0.351 NM_201236
Rhox4e
reproductive homeobox 4E
chr5_-_130363128 0.332 Chchd2
coiled-coil-helix-coiled-coil-helix domain containing 2
chr11_-_106642357 0.322 Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr9_+_77602337 0.312 Gclc
glutamate-cysteine ligase, catalytic subunit
chr8_+_113618575 0.255 NM_198308
Pdpr
pyruvate dehydrogenase phosphatase regulatory subunit
chrX_+_34805369 0.223 NM_001039688
Rhox4a
reproductive homeobox 4A
chr16_-_21995441 0.214 NM_153404
NM_001083894
Liph

lipase, member H

chr11_-_11798035 0.205 Ddc
dopa decarboxylase
chr12_-_111934448 0.193 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr9_+_43118845 0.162 NM_023655
Trim29
tripartite motif-containing 29
chrX_+_34847000 0.141 NM_021300
Rhox4e
Rhox4b
Rhox4d
reproductive homeobox 4E
reproductive homeobox 4B
reproductive homeobox 4D
chrX_-_151524332 0.138 NM_020015
Magea1
melanoma antigen, family A, 1
chr10_+_80102813 0.109 Csnk1g2
casein kinase 1, gamma 2
chr15_+_57747523 0.108 Wdr67
WD repeat domain 67
chr2_+_29933228 0.106 Pkn3
protein kinase N3
chr7_-_5068497 0.099 NM_001145013
NM_138954
Rfpl4

ret finger protein-like 4

chr15_-_96886327 0.096 NM_027052
Slc38a4
solute carrier family 38, member 4
chr14_-_53110720 0.080 NM_020512
Olfr1507
olfactory receptor 1507
chr19_-_42358648 0.075 Crtac1
cartilage acidic protein 1
chr5_-_33560819 0.043 NM_133903
Spon2
spondin 2, extracellular matrix protein
chr19_+_11611327 0.020 NM_025658
Ms4a4d
membrane-spanning 4-domains, subfamily A, member 4D
chr10_-_90586710 0.019 Slc25a3
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
chr2_-_48804672 0.019 NM_001177313
NM_011958
Orc4

origin recognition complex, subunit 4


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
66.25 4.18e-03 GO:0006534 cysteine metabolic process
25.77 7.35e-03 GO:0009069 serine family amino acid metabolic process
154.58 1.92e-02 GO:0070813 hydrogen sulfide metabolic process
154.58 1.92e-02 GO:0070814 hydrogen sulfide biosynthetic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
154.58 5.77e-03 GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity