Motif ID: RREB1.p2

Z-value: 1.383


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
Rreb1 68750 ras responsive element binding protein 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1chr13_+_37918780,
chr13_+_37919261,
chr13_+_37917906
-0.431.0e-09Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_110783593 24.228 Meg3
maternally expressed 3
chr7_-_31838140 21.233 Fxyd1
FXYD domain-containing ion transport regulator 1
chr9_+_36640268 18.884 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr12_+_110783786 18.042 Meg3
maternally expressed 3
chr18_-_33623069 17.801 NM_001109990
D0H4S114
DNA segment, human D4S114
chr18_-_33623668 17.497 NM_001109988
D0H4S114
DNA segment, human D4S114
chr18_-_33623400 15.653 NM_001109989
D0H4S114
DNA segment, human D4S114
chr4_-_150482562 14.539 Camta1
calmodulin binding transcription activator 1
chr1_-_125942073 13.597 NM_199021
Dpp10
dipeptidylpeptidase 10
chr13_-_78337844 13.192 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr11_-_59263437 12.869 NM_144521
Snap47
synaptosomal-associated protein, 47
chr18_-_33623287 12.774 NM_053078
D0H4S114
DNA segment, human D4S114
chr2_+_92439758 12.443 NM_023850
Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr6_+_88775664 12.279 Mgll
monoglyceride lipase
chr17_+_37210011 11.764 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_-_70847078 11.666 NM_134022
6330403K07Rik
RIKEN cDNA 6330403K07 gene
chr12_+_110782654 11.323 Meg3
maternally expressed 3
chr4_-_82150687 11.213 Nfib
nuclear factor I/B
chr11_-_70846926 11.002 6330403K07Rik
RIKEN cDNA 6330403K07 gene
chr3_-_84063605 10.963 Trim2
tripartite motif-containing 2
chr5_-_139605617 10.753 NM_008923
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr17_+_44090139 10.611 NM_030598
Rcan2
regulator of calcineurin 2
chr17_+_44090222 10.349 Rcan2
regulator of calcineurin 2
chr7_-_149763980 10.085 H19
H19 fetal liver mRNA
chr4_+_147534729 9.807 Fbxo2
F-box protein 2
chr4_+_147534776 9.724 NM_176848
Fbxo2
F-box protein 2
chr3_+_95985065 9.715 NM_022030
Sv2a
synaptic vesicle glycoprotein 2 a
chr14_+_68701838 9.444 NM_010910
Nefl
neurofilament, light polypeptide
chrX_+_133200982 9.138 Tceal3
transcription elongation factor A (SII)-like 3
chr15_+_54577256 8.994 NM_010930
Nov
nephroblastoma overexpressed gene
chrX_+_133200913 8.964 NM_001029978
Tceal3
transcription elongation factor A (SII)-like 3
chr2_-_91772424 8.909 NM_010784
Mdk
midkine
chr1_-_79855177 8.799 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr3_+_55265654 8.759 NM_001111051
NM_001111052
NM_001195539
NM_001195540
Dclk1



doublecortin-like kinase 1



chr9_+_98325217 8.734 Rbp1
retinol binding protein 1, cellular
chr1_-_79855229 8.522 NM_009255
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr15_-_98638230 8.505 Ddn
dendrin
chr11_-_59263508 8.477 Snap47
synaptosomal-associated protein, 47
chr10_+_69903653 8.365 NM_001143776
NM_024244
Fam13c

family with sequence similarity 13, member C

chr1_-_84281018 8.339 Pid1
phosphotyrosine interaction domain containing 1
chr1_-_79855209 8.333 Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr10_-_42893894 8.108 Sobp
sine oculis-binding protein homolog (Drosophila)
chr8_+_98201984 8.060


chr14_-_71035662 7.842 Epb4.9
erythrocyte protein band 4.9
chr7_-_149838254 7.832 Igf2
insulin-like growth factor 2
chr11_+_54128404 7.757 NM_001033599
Acsl6
acyl-CoA synthetase long-chain family member 6
chr8_+_96334879 7.699 Gnao1
guanine nucleotide binding protein, alpha O
chr9_+_75161942 7.668 NM_138719
Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr2_+_70400179 7.667 NM_008077
Gad1
glutamic acid decarboxylase 1
chr17_+_44090341 7.612 Rcan2
regulator of calcineurin 2
chrX_+_53984926 7.587 NM_010211
Fhl1
four and a half LIM domains 1
chr14_-_57752102 7.531 Gjb6
gap junction protein, beta 6
chr7_-_119301920 7.491 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chrX_+_53985133 7.470 NM_001077361
Fhl1
four and a half LIM domains 1
chr9_-_91260597 7.398 Zic1
zinc finger protein of the cerebellum 1
chr17_+_44090192 7.343 Rcan2
regulator of calcineurin 2
chr15_-_37721754 7.340 NM_001170866
Ncald
neurocalcin delta
chr6_-_113841295 7.286 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chrX_+_132373572 7.212 NM_001163015
NM_001163016
NM_001163017
Gprasp2


G protein-coupled receptor associated sorting protein 2


chr7_+_35971403 7.150 NM_017394
Slc7a10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chrX_-_70905062 7.133 NM_012040
Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr1_-_84281164 7.117 NM_001003948
Pid1
phosphotyrosine interaction domain containing 1
chr11_-_90250949 7.112 Hlf
hepatic leukemia factor
chr10_-_79600131 7.108 NM_001195268
Dos
downstream of Stk11
chr4_-_82151004 7.074 Nfib
nuclear factor I/B
chr9_-_91260619 7.057 NM_009573
Zic1
zinc finger protein of the cerebellum 1
chr10_+_59569052 7.043 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr14_-_57752270 6.937 NM_001010937
Gjb6
gap junction protein, beta 6
chr18_-_16967100 6.894 Cdh2
cadherin 2
chr3_+_55265811 6.853 Dclk1
doublecortin-like kinase 1
chr2_-_91771919 6.780 NM_001012336
Mdk
midkine
chr17_+_35960291 6.770 NM_008027
Flot1
flotillin 1
chrX_-_131745187 6.700 NM_025355
Tceal6
transcription elongation factor A (SII)-like 6
chr1_-_42751652 6.674 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr13_+_46597271 6.524 NM_026056
Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr14_-_8491067 6.519 Gm2897
predicted gene 2897
chr13_+_42961598 6.503 Phactr1
phosphatase and actin regulator 1
chr7_-_112781902 6.390 NM_018880
Trim3
tripartite motif-containing 3
chr6_-_113841356 6.352 NM_001036684
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr2_-_156218547 6.314 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr17_+_81343933 6.292 NM_026516
Tmem178
transmembrane protein 178
chr6_-_124719465 6.180 NM_013509
Eno2
enolase 2, gamma neuronal
chr4_-_82151180 6.158 NM_001113209
NM_001113210
NM_008687
Nfib


nuclear factor I/B


chr10_-_108447674 6.122 NM_009306
Syt1
synaptotagmin I
chr1_-_195099285 6.121 NM_008059
G0s2
G0/G1 switch gene 2
chr14_-_7937970 6.120 NM_001024712
Gm3696
predicted gene 3696
chr13_+_46597461 6.111 Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr7_-_25772525 6.096 Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr4_-_128798939 6.070 NM_001130419
Hpca
hippocalcin
chr4_+_33295965 6.035 NM_177774
Srsf13b
serine/arginine-rich splicing factor 13B
chr5_+_143734622 6.032


chr5_-_52957466 6.022 Lgi2
leucine-rich repeat LGI family, member 2
chr5_+_18732863 6.020 NM_001170746
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_83404659 6.005 NM_172430
Sphkap
SPHK1 interactor, AKAP domain containing
chr14_-_71018208 5.989 Epb4.9
erythrocyte protein band 4.9
chr2_-_91771882 5.975 Mdk
midkine
chr2_-_91771836 5.967 NM_001012335
Mdk
midkine
chr15_+_89330287 5.904 NM_021423
Shank3
SH3/ankyrin domain gene 3
chrX_+_54043764 5.900 Fhl1
four and a half LIM domains 1
chr15_-_75397030 5.816 NM_001135689
Ly6h
lymphocyte antigen 6 complex, locus H
chr8_+_75095914 5.806 NM_144534
Nwd1
Tmem38a
NACHT and WD repeat domain containing 1
transmembrane protein 38A
chr3_+_10012576 5.785 NM_010634
Fabp5
fatty acid binding protein 5, epidermal
chr8_+_87162885 5.775 Cacna1a
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr11_-_116668593 5.755


chr13_+_46597448 5.753 Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr4_-_147534144 5.753 NM_001161852
NM_173401
Fbxo44

F-box protein 44

chr12_+_110800212 5.738 Meg3
maternally expressed 3
chr3_-_152331083 5.718 NM_001081277
Ak5
adenylate kinase 5
chr18_+_59222034 5.702 NM_001167925
NM_173759
A730017C20Rik

RIKEN cDNA A730017C20 gene

chr2_-_180689328 5.694 Nkain4
Na+/K+ transporting ATPase interacting 4
chr6_-_127718746 5.648 NM_201371
Prmt8
protein arginine N-methyltransferase 8
chr7_+_4642529 5.512 NM_001003920
NM_001168572
Brsk1

BR serine/threonine kinase 1

chr9_+_106356125 5.461 NM_021567
Pcbp4
poly(rC) binding protein 4
chr2_+_131735663 5.459 NM_011170
Prnp
prion protein
chr2_+_25098448 5.423 NM_176834
Rnf208
ring finger protein 208
chr11_+_54117703 5.417 NM_001033597
NM_144823
Acsl6

acyl-CoA synthetase long-chain family member 6

chr1_+_72871060 5.371 NM_008342
Igfbp2
insulin-like growth factor binding protein 2
chr9_+_72510153 5.290 NM_010890
Nedd4
neural precursor cell expressed, developmentally down-regulated 4
chr6_+_17231334 5.236 NM_016900
Cav2
caveolin 2
chr19_-_8913619 5.226 NM_010316
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr13_+_59234737 5.161 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr9_+_75162059 5.150 Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr2_-_152202301 5.144 NM_001009948
Nrsn2
neurensin 2
chr4_+_126287086 5.095 NM_001013755
NM_001145950
5730409E04Rik

RIKEN cDNA 5730409E04Rik gene

chr9_+_75192367 5.085 Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr5_+_148768875 5.083 NM_029920
Mtus2
microtubule associated tumor suppressor candidate 2
chr5_-_123229335 5.081 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr17_+_25945986 5.040 NM_001164225
Fbxl16
F-box and leucine-rich repeat protein 16
chr2_-_180689380 5.036 NM_001141933
NM_021426
Nkain4

Na+/K+ transporting ATPase interacting 4

chr7_-_108043203 5.030 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr14_-_7859962 5.004 NM_001164727
Gm10406
predicted gene 10406
chr2_+_164793487 5.002 NM_020333
Slc12a5
solute carrier family 12, member 5
chr10_-_127058163 4.999 Lrp1
low density lipoprotein receptor-related protein 1
chr4_-_82151590 4.989 Nfib
nuclear factor I/B
chr17_+_27792587 4.979 NM_011861
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr16_+_37777075 4.960 NM_008047
Fstl1
follistatin-like 1
chr17_+_27792487 4.958 Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr3_-_18143265 4.945 NM_007825
Cyp7b1
cytochrome P450, family 7, subfamily b, polypeptide 1
chr6_-_124813922 4.943 NM_013533
Gpr162
G protein-coupled receptor 162
chr7_-_112730004 4.940 NM_009685
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr6_-_92431385 4.934 NM_001134460
Prickle2
prickle homolog 2 (Drosophila)
chr15_+_98465193 4.921 NM_007581
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr2_-_180891448 4.911 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr8_+_59934719 4.897 NM_009136
Scrg1
scrapie responsive gene 1
chr15_-_90880241 4.891 NM_001109040
NM_001109041
NM_001109042
NM_016705
Kif21a



kinesin family member 21A



chr8_-_126417352 4.875 Acta1
actin, alpha 1, skeletal muscle
chr16_+_41533317 4.865 NM_175548
Lsamp
limbic system-associated membrane protein
chr10_-_42894259 4.850 NM_175407
Sobp
sine oculis-binding protein homolog (Drosophila)
chr7_-_31836457 4.826 NM_022007
Fxyd7
FXYD domain-containing ion transport regulator 7
chr13_-_12432984 4.816 NM_033268
Actn2
actinin alpha 2
chr2_-_168567436 4.801 Atp9a
ATPase, class II, type 9A
chrX_+_133242520 4.795 NM_146236
Tceal1
transcription elongation factor A (SII)-like 1
chr7_+_53693190 4.773 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr14_-_52530382 4.770 Ndrg2
N-myc downstream regulated gene 2
chrX_+_7215705 4.764 NM_009305
Syp
synaptophysin
chr1_-_186823350 4.731 NM_145515
Mark1
MAP/microtubule affinity-regulating kinase 1
chr19_-_61304260 4.726 NM_009970
Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr7_+_133968166 4.722 NM_001146347
Fam57b
family with sequence similarity 57, member B
chr11_-_90252208 4.705 Hlf
hepatic leukemia factor
chrX_+_7496899 4.702 NM_013892
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_+_54117299 4.700 NM_001033598
Acsl6
acyl-CoA synthetase long-chain family member 6
chr12_+_72038843 4.699 NM_019785
Actr10
ARP10 actin-related protein 10 homolog (S. cerevisiae)
chrX_+_50911075 4.667 NM_028375
Cxx1c
CAAX box 1 homolog C (human)
chr4_+_17780628 4.616 NM_019724
Mmp16
matrix metallopeptidase 16
chr8_-_87297283 4.605 Nfix
nuclear factor I/X
chr16_+_35001358 4.599 Mylk
myosin, light polypeptide kinase
chr13_-_78338131 4.553 NM_010151
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr6_-_126594802 4.539 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr2_+_103798150 4.516 NM_001142337
Lmo2
LIM domain only 2
chr19_+_44368557 4.509 Scd2
stearoyl-Coenzyme A desaturase 2
chr4_+_104830022 4.495 Ppap2b
phosphatidic acid phosphatase type 2B
chr1_+_75542840 4.477 NM_009208
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr8_+_124254462 4.467 NM_020605
Jph3
junctophilin 3
chrX_-_149471740 4.460 NM_023788
Mageh1
melanoma antigen, family H, 1
chrX_+_102318792 4.457 Magee1
melanoma antigen, family E, 1
chr2_+_55289530 4.438 NM_008426
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr4_+_97444312 4.420 NM_001122953
NM_010905
Nfia

nuclear factor I/A

chr15_-_75397243 4.412 NM_001135688
Ly6h
lymphocyte antigen 6 complex, locus H
chr7_-_112729716 4.394 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr8_-_87298118 4.368 NM_001081981
Nfix
nuclear factor I/X
chr6_-_126690651 4.353 NM_013568
Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr18_+_23656024 4.342 Dtna
dystrobrevin alpha
chr4_+_17780739 4.340 Mmp16
matrix metallopeptidase 16
chrX_+_162676870 4.337 NM_001177961
NM_001177962
NM_023122
Gpm6b


glycoprotein m6b


chr11_-_50641191 4.323 NM_013922
Zfp354c
zinc finger protein 354C
chr15_+_97942484 4.315 NM_021514
Pfkm
phosphofructokinase, muscle
chr18_-_13020914 4.291 Osbpl1a
oxysterol binding protein-like 1A
chr3_-_69402739 4.280 NM_020026
B3galnt1
UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
chr19_+_44368578 4.268 Scd2
stearoyl-Coenzyme A desaturase 2
chr3_-_81878554 4.260 NM_001161796
NM_017469
Gucy1b3

guanylate cyclase 1, soluble, beta 3

chr13_-_25361773 4.240 NM_009513
Nrsn1
neurensin 1
chr4_+_155213834 4.238 Mxra8
matrix-remodelling associated 8
chr4_+_155213788 4.229 NM_024263
Mxra8
matrix-remodelling associated 8
chr17_-_47824991 4.227 Tomm6
translocase of outer mitochondrial membrane 6 homolog (yeast)
chr6_+_45010040 4.179 NM_001004357
Cntnap2
contactin associated protein-like 2
chr16_-_45408997 4.178 NM_010818
Cd200
2300009N04Rik
CD200 antigen
RIKEN cDNA 2300009N04 gene
chr17_+_35960248 4.166 Flot1
flotillin 1
chr1_+_94728217 4.159 NM_016696
Gpc1
glypican 1
chr5_+_27588579 4.144 Dpp6
dipeptidylpeptidase 6
chr6_+_65621583 4.139 NM_172399
A930038C07Rik
RIKEN cDNA A930038C07 gene

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.73 5.03e-18 GO:0007399 nervous system development
1.62 4.22e-16 GO:0023051 regulation of signaling
1.45 5.20e-16 GO:0048731 system development
1.38 1.17e-14 GO:0007275 multicellular organismal development
1.41 1.49e-14 GO:0048856 anatomical structure development
1.36 4.37e-14 GO:0032502 developmental process
1.51 5.45e-14 GO:0065008 regulation of biological quality
1.67 8.14e-13 GO:0032879 regulation of localization
1.78 1.61e-12 GO:0048699 generation of neurons
1.34 4.10e-12 GO:0051179 localization
1.73 4.71e-12 GO:0022008 neurogenesis
1.63 6.19e-12 GO:0010646 regulation of cell communication
1.50 8.04e-11 GO:0051239 regulation of multicellular organismal process
1.43 9.33e-11 GO:0030154 cell differentiation
1.41 5.03e-10 GO:0048869 cellular developmental process
1.39 5.70e-10 GO:0048523 negative regulation of cellular process
1.76 5.87e-10 GO:0007154 cell communication
1.54 1.14e-09 GO:0009966 regulation of signal transduction
2.08 1.80e-09 GO:0031175 neuron projection development
1.96 2.02e-09 GO:0044057 regulation of system process
1.49 2.67e-09 GO:0009653 anatomical structure morphogenesis
2.06 2.88e-09 GO:0019226 transmission of nerve impulse
2.06 2.88e-09 GO:0035637 multicellular organismal signaling
1.36 3.00e-09 GO:0048519 negative regulation of biological process
1.67 1.10e-08 GO:0051049 regulation of transport
1.62 1.18e-08 GO:0048468 cell development
1.45 1.66e-08 GO:0065009 regulation of molecular function
1.90 2.00e-08 GO:0048666 neuron development
1.43 2.09e-08 GO:0048583 regulation of response to stimulus
2.14 2.93e-08 GO:0007268 synaptic transmission
1.31 3.27e-08 GO:0048518 positive regulation of biological process
1.32 4.41e-08 GO:0006810 transport
1.61 5.70e-08 GO:0051128 regulation of cellular component organization
2.27 6.06e-08 GO:0051969 regulation of transmission of nerve impulse
1.31 6.11e-08 GO:0051234 establishment of localization
1.87 1.04e-07 GO:0007267 cell-cell signaling
1.32 1.08e-07 GO:0048522 positive regulation of cellular process
1.29 2.60e-07 GO:0016043 cellular component organization
2.27 3.52e-07 GO:0050804 regulation of synaptic transmission
1.74 3.57e-07 GO:0030182 neuron differentiation
2.15 4.95e-07 GO:0031644 regulation of neurological system process
2.23 5.12e-07 GO:0031344 regulation of cell projection organization
1.85 5.25e-07 GO:0060284 regulation of cell development
1.65 1.59e-06 GO:0007155 cell adhesion
1.64 2.92e-06 GO:0022610 biological adhesion
2.28 3.22e-06 GO:0042391 regulation of membrane potential
1.73 3.33e-06 GO:0030030 cell projection organization
2.53 3.35e-06 GO:0003012 muscle system process
1.84 3.62e-06 GO:0051960 regulation of nervous system development
1.99 3.91e-06 GO:0045664 regulation of neuron differentiation
1.88 4.94e-06 GO:0050767 regulation of neurogenesis
2.24 9.52e-06 GO:0010975 regulation of neuron projection development
2.00 9.95e-06 GO:0048812 neuron projection morphogenesis
1.75 1.02e-05 GO:0060341 regulation of cellular localization
1.46 1.39e-05 GO:0035556 intracellular signal transduction
1.74 1.84e-05 GO:0006873 cellular ion homeostasis
1.72 1.99e-05 GO:0055082 cellular chemical homeostasis
1.21 2.16e-05 GO:0019222 regulation of metabolic process
1.69 2.53e-05 GO:0050801 ion homeostasis
1.25 2.56e-05 GO:0071840 cellular component organization or biogenesis
1.59 4.23e-05 GO:0042325 regulation of phosphorylation
1.57 4.76e-05 GO:0019220 regulation of phosphate metabolic process
1.57 4.76e-05 GO:0051174 regulation of phosphorus metabolic process
1.85 4.77e-05 GO:0000904 cell morphogenesis involved in differentiation
1.65 4.84e-05 GO:0072358 cardiovascular system development
1.65 4.84e-05 GO:0072359 circulatory system development
1.79 5.17e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.64 5.41e-05 GO:0019725 cellular homeostasis
1.82 5.49e-05 GO:0051046 regulation of secretion
1.67 8.57e-05 GO:0032989 cellular component morphogenesis
1.60 1.03e-04 GO:0001932 regulation of protein phosphorylation
1.40 1.21e-04 GO:0050790 regulation of catalytic activity
2.24 1.25e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.24 1.25e-04 GO:0022604 regulation of cell morphogenesis
2.06 1.29e-04 GO:0043269 regulation of ion transport
2.45 1.67e-04 GO:0006936 muscle contraction
1.68 1.69e-04 GO:0000902 cell morphogenesis
1.47 1.73e-04 GO:2000026 regulation of multicellular organismal development
1.73 1.79e-04 GO:0007610 behavior
1.69 1.88e-04 GO:0023057 negative regulation of signaling
1.81 1.98e-04 GO:0048858 cell projection morphogenesis
1.69 2.15e-04 GO:0010648 negative regulation of cell communication
1.42 3.18e-04 GO:0010941 regulation of cell death
1.45 3.47e-04 GO:0042592 homeostatic process
1.78 3.51e-04 GO:0040012 regulation of locomotion
1.56 4.00e-04 GO:0040011 locomotion
1.78 4.86e-04 GO:0032990 cell part morphogenesis
1.41 5.17e-04 GO:0050793 regulation of developmental process
1.48 5.30e-04 GO:0045595 regulation of cell differentiation
3.66 5.76e-04 GO:0046928 regulation of neurotransmitter secretion
1.61 6.09e-04 GO:0060548 negative regulation of cell death
1.20 6.26e-04 GO:0031323 regulation of cellular metabolic process
1.54 6.65e-04 GO:0048878 chemical homeostasis
2.39 7.84e-04 GO:0031346 positive regulation of cell projection organization
1.69 8.26e-04 GO:0090066 regulation of anatomical structure size
1.74 8.27e-04 GO:0035295 tube development
1.86 1.01e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.11 1.08e-03 GO:0065007 biological regulation
1.91 1.14e-03 GO:0007409 axonogenesis
1.86 1.39e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.61 1.43e-03 GO:0043066 negative regulation of apoptosis
1.40 1.75e-03 GO:0006796 phosphate metabolic process
1.40 1.81e-03 GO:0042981 regulation of apoptosis
1.70 2.01e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.40 2.03e-03 GO:0006793 phosphorus metabolic process
1.66 2.08e-03 GO:0009968 negative regulation of signal transduction
1.76 2.32e-03 GO:2000145 regulation of cell motility
2.12 2.50e-03 GO:0010959 regulation of metal ion transport
1.67 2.65e-03 GO:0051050 positive regulation of transport
1.39 2.66e-03 GO:0043067 regulation of programmed cell death
3.84 2.78e-03 GO:0051966 regulation of synaptic transmission, glutamatergic
1.59 2.81e-03 GO:0043069 negative regulation of programmed cell death
1.88 3.08e-03 GO:0046578 regulation of Ras protein signal transduction
1.45 3.53e-03 GO:0031399 regulation of protein modification process
1.71 3.62e-03 GO:0051270 regulation of cellular component movement
1.70 4.01e-03 GO:0001944 vasculature development
3.27 4.91e-03 GO:0051588 regulation of neurotransmitter transport
1.18 5.48e-03 GO:0080090 regulation of primary metabolic process
1.73 5.64e-03 GO:0030334 regulation of cell migration
2.04 6.16e-03 GO:0006813 potassium ion transport
1.37 6.22e-03 GO:0051246 regulation of protein metabolic process
1.55 6.59e-03 GO:0048585 negative regulation of response to stimulus
1.83 6.91e-03 GO:0051129 negative regulation of cellular component organization
1.63 7.04e-03 GO:0016477 cell migration
1.42 7.74e-03 GO:0006811 ion transport
1.52 1.24e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.24 1.28e-02 GO:0071842 cellular component organization at cellular level
1.51 1.28e-02 GO:0010647 positive regulation of cell communication
1.56 1.32e-02 GO:0006928 cellular component movement
2.98 1.42e-02 GO:0007270 nerve-nerve synaptic transmission
1.52 1.55e-02 GO:0030001 metal ion transport
1.47 1.57e-02 GO:0009887 organ morphogenesis
1.10 1.61e-02 GO:0050789 regulation of biological process
1.69 1.64e-02 GO:0001568 blood vessel development
1.50 1.71e-02 GO:0023056 positive regulation of signaling
2.02 1.72e-02 GO:0007626 locomotory behavior
1.65 1.97e-02 GO:0032535 regulation of cellular component size
2.33 2.09e-02 GO:0050770 regulation of axonogenesis
2.50 2.14e-02 GO:0032409 regulation of transporter activity
1.50 2.19e-02 GO:0051094 positive regulation of developmental process
1.77 2.35e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.81 2.48e-02 GO:0044087 regulation of cellular component biogenesis
1.40 2.63e-02 GO:0044093 positive regulation of molecular function
1.76 2.66e-02 GO:0030029 actin filament-based process
1.17 2.72e-02 GO:0060255 regulation of macromolecule metabolic process
2.96 2.89e-02 GO:0021549 cerebellum development
1.78 3.26e-02 GO:0030036 actin cytoskeleton organization
6.05 3.37e-02 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
1.46 3.42e-02 GO:0006812 cation transport
1.35 3.43e-02 GO:0032268 regulation of cellular protein metabolic process
1.73 3.44e-02 GO:0048514 blood vessel morphogenesis
1.68 3.73e-02 GO:0006140 regulation of nucleotide metabolic process
2.23 3.97e-02 GO:0034765 regulation of ion transmembrane transport
1.55 3.98e-02 GO:0040008 regulation of growth
1.87 4.08e-02 GO:0043062 extracellular structure organization
1.38 4.31e-02 GO:0016310 phosphorylation
2.25 4.45e-02 GO:0031589 cell-substrate adhesion
1.84 4.81e-02 GO:0040017 positive regulation of locomotion
1.70 4.87e-02 GO:0061061 muscle structure development
2.15 4.91e-02 GO:0030534 adult behavior

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.47 6.14e-34 GO:0043005 neuron projection
2.35 1.22e-24 GO:0045202 synapse
1.42 1.47e-24 GO:0071944 cell periphery
1.40 1.65e-22 GO:0005886 plasma membrane
1.82 1.81e-22 GO:0042995 cell projection
1.23 4.07e-22 GO:0005737 cytoplasm
2.76 1.87e-21 GO:0030424 axon
2.45 1.12e-19 GO:0044297 cell body
2.49 1.44e-19 GO:0043025 neuronal cell body
2.57 5.58e-19 GO:0030425 dendrite
1.15 8.27e-18 GO:0005622 intracellular
2.32 3.44e-16 GO:0044456 synapse part
1.51 1.54e-15 GO:0044459 plasma membrane part
1.14 4.41e-15 GO:0044424 intracellular part
1.86 2.00e-13 GO:0030054 cell junction
2.18 1.54e-12 GO:0031012 extracellular matrix
2.02 3.04e-12 GO:0044463 cell projection part
1.61 1.24e-10 GO:0044421 extracellular region part
2.77 2.30e-10 GO:0033267 axon part
2.89 2.64e-10 GO:0044420 extracellular matrix part
1.21 3.15e-10 GO:0044444 cytoplasmic part
2.14 4.08e-10 GO:0005578 proteinaceous extracellular matrix
1.07 6.93e-10 GO:0005623 cell
1.07 6.93e-10 GO:0044464 cell part
1.60 7.76e-10 GO:0005626 insoluble fraction
1.52 1.01e-09 GO:0000267 cell fraction
1.57 1.34e-08 GO:0005624 membrane fraction
2.40 4.48e-08 GO:0045211 postsynaptic membrane
2.33 5.94e-08 GO:0034702 ion channel complex
2.95 1.61e-06 GO:0044309 neuron spine
1.92 2.49e-06 GO:0015629 actin cytoskeleton
2.80 2.73e-06 GO:0030427 site of polarized growth
2.82 3.76e-06 GO:0005604 basement membrane
2.82 3.76e-06 GO:0030426 growth cone
1.37 5.66e-06 GO:0005856 cytoskeleton
2.34 5.76e-06 GO:0019717 synaptosome
2.16 1.27e-05 GO:0030135 coated vesicle
2.84 1.42e-05 GO:0043197 dendritic spine
1.11 1.42e-05 GO:0043226 organelle
1.11 1.54e-05 GO:0043229 intracellular organelle
1.31 2.37e-05 GO:0005576 extracellular region
2.46 3.47e-05 GO:0034703 cation channel complex
1.50 4.42e-05 GO:0005615 extracellular space
2.28 7.23e-05 GO:0043292 contractile fiber
1.23 8.23e-05 GO:0043234 protein complex
2.66 8.33e-05 GO:0043679 axon terminus
1.11 8.89e-05 GO:0016020 membrane
2.44 9.31e-05 GO:0008021 synaptic vesicle
2.15 1.03e-04 GO:0005938 cell cortex
2.58 1.13e-04 GO:0042383 sarcolemma
3.45 1.25e-04 GO:0043198 dendritic shaft
2.55 1.55e-04 GO:0044306 neuron projection terminus
2.30 1.62e-04 GO:0030016 myofibril
2.13 1.82e-04 GO:0030136 clathrin-coated vesicle
1.55 2.19e-04 GO:0031988 membrane-bounded vesicle
1.40 3.01e-04 GO:0005794 Golgi apparatus
1.74 3.72e-04 GO:0048471 perinuclear region of cytoplasm
1.56 3.74e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
5.32 3.98e-04 GO:0005583 fibrillar collagen
2.50 4.02e-04 GO:0014069 postsynaptic density
2.40 4.69e-04 GO:0030017 sarcomere
2.02 6.73e-04 GO:0030659 cytoplasmic vesicle membrane
1.96 9.14e-04 GO:0012506 vesicle membrane
3.00 1.01e-03 GO:0043195 terminal button
1.95 1.10e-03 GO:0031252 cell leading edge
3.57 1.36e-03 GO:0030672 synaptic vesicle membrane
2.24 1.40e-03 GO:0044449 contractile fiber part
1.44 1.59e-03 GO:0031410 cytoplasmic vesicle
1.96 1.74e-03 GO:0044433 cytoplasmic vesicle part
1.42 2.10e-03 GO:0031982 vesicle
3.34 3.95e-03 GO:0044304 main axon
2.62 4.78e-03 GO:0005901 caveola
1.17 5.06e-03 GO:0032991 macromolecular complex
1.35 7.92e-03 GO:0044430 cytoskeletal part
2.94 8.62e-03 GO:0042734 presynaptic membrane
2.45 1.14e-02 GO:0031674 I band
2.37 1.39e-02 GO:0030662 coated vesicle membrane
2.22 1.68e-02 GO:0044448 cell cortex part
1.26 1.69e-02 GO:0005829 cytosol
2.37 1.99e-02 GO:0008076 voltage-gated potassium channel complex
2.37 1.99e-02 GO:0034705 potassium channel complex
3.62 2.63e-02 GO:0034704 calcium channel complex
2.52 3.52e-02 GO:0030863 cortical cytoskeleton

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.37 3.98e-34 GO:0005515 protein binding
1.19 2.85e-27 GO:0005488 binding
1.94 9.75e-13 GO:0008092 cytoskeletal protein binding
2.87 2.52e-10 GO:0005516 calmodulin binding
1.82 1.64e-09 GO:0005509 calcium ion binding
2.69 4.51e-09 GO:0022843 voltage-gated cation channel activity
2.03 1.99e-08 GO:0003779 actin binding
2.06 2.73e-08 GO:0022836 gated channel activity
1.26 5.56e-08 GO:0046872 metal ion binding
2.30 1.23e-07 GO:0005244 voltage-gated ion channel activity
2.30 1.23e-07 GO:0022832 voltage-gated channel activity
1.25 1.55e-07 GO:0043169 cation binding
1.87 1.58e-07 GO:0005216 ion channel activity
1.25 2.09e-07 GO:0043167 ion binding
1.85 2.58e-07 GO:0022838 substrate-specific channel activity
1.83 3.52e-07 GO:0015267 channel activity
1.83 4.12e-07 GO:0022803 passive transmembrane transporter activity
1.79 1.41e-06 GO:0030695 GTPase regulator activity
1.76 3.85e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.51 6.14e-06 GO:0030234 enzyme regulator activity
2.69 9.99e-06 GO:0005249 voltage-gated potassium channel activity
1.49 1.02e-05 GO:0019899 enzyme binding
2.40 1.31e-05 GO:0005267 potassium channel activity
1.90 5.06e-05 GO:0005261 cation channel activity
2.18 5.77e-05 GO:0001871 pattern binding
2.18 5.77e-05 GO:0030247 polysaccharide binding
1.59 1.26e-04 GO:0019904 protein domain specific binding
2.37 2.65e-04 GO:0019838 growth factor binding
2.18 2.65e-04 GO:0005539 glycosaminoglycan binding
4.61 6.15e-04 GO:0004683 calmodulin-dependent protein kinase activity
1.38 6.16e-04 GO:0005215 transporter activity
1.46 9.85e-04 GO:0046983 protein dimerization activity
1.88 1.29e-03 GO:0005096 GTPase activator activity
1.78 1.43e-03 GO:0005083 small GTPase regulator activity
1.40 1.98e-03 GO:0022857 transmembrane transporter activity
1.39 2.09e-03 GO:0022892 substrate-specific transporter activity
1.42 2.23e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.36 2.40e-03 GO:0005102 receptor binding
1.68 2.84e-03 GO:0008047 enzyme activator activity
1.68 3.46e-03 GO:0019900 kinase binding
1.45 3.63e-03 GO:0015075 ion transmembrane transporter activity
5.18 3.76e-03 GO:0005159 insulin-like growth factor receptor binding
2.46 5.21e-03 GO:0019199 transmembrane receptor protein kinase activity
1.39 7.64e-03 GO:0042802 identical protein binding
6.91 8.61e-03 GO:0008113 peptide-methionine-(S)-S-oxide reductase activity
1.26 1.05e-02 GO:0046914 transition metal ion binding
3.34 1.46e-02 GO:0005201 extracellular matrix structural constituent
1.49 1.96e-02 GO:0042803 protein homodimerization activity
1.56 2.29e-02 GO:0032403 protein complex binding
2.10 2.78e-02 GO:0008201 heparin binding
2.46 4.10e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity