Motif ID: SMAD1..7,9.p2

Z-value: 1.171


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
Smad1 17125 MAD homolog 1 (Drosophila)
Smad2 17126 MAD homolog 2 (Drosophila)
Smad3 17127 MAD homolog 3 (Drosophila)
Smad4 17128 MAD homolog 4 (Drosophila)
Smad5 17129 MAD homolog 5 (Drosophila)
Smad6 17130 MAD homolog 6 (Drosophila)
Smad7 17131 MAD homolog 7 (Drosophila)
Smad9 55994 MAD homolog 9 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2chr18_+_76401531-0.451.1e-10Click!
Smad1chr8_-_819232380.154.0e-02Click!
Smad7chr18_+_755270150.111.3e-01Click!
Smad3chr9_-_636057450.101.6e-01Click!
Smad4chr18_-_738633810.101.9e-01Click!
Smad9chr3_+_54559503-0.046.0e-01Click!
Smad6chr9_-_63868311-0.037.3e-01Click!
Smad5chr13_+_568043700.019.1e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_55233354 12.264 Sparc
secreted acidic cysteine rich glycoprotein
chr11_-_64976408 11.198 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr7_+_138122822 10.921 Htra1
HtrA serine peptidase 1
chr17_+_43526389 10.580 NM_001081178
Gpr116
G protein-coupled receptor 116
chr2_+_136539202 10.404 Snap25
synaptosomal-associated protein 25
chr11_-_55233581 10.304 NM_009242
Sparc
secreted acidic cysteine rich glycoprotein
chrX_+_10173557 10.159


chr16_+_96689206 9.825 NM_008791
Pcp4
Purkinje cell protein 4
chr1_+_75356913 9.797 NM_010043
Des
desmin
chr2_+_136539143 9.526 NM_011428
Snap25
synaptosomal-associated protein 25
chr8_-_126418628 9.332 NM_009606
Acta1
actin, alpha 1, skeletal muscle
chr1_+_75356906 8.764 Des
desmin
chr11_-_55233366 8.423 Sparc
secreted acidic cysteine rich glycoprotein
chr2_-_127481868 8.145 Mal
myelin and lymphocyte protein, T-cell differentiation protein
chr7_+_19996439 8.143 NM_007710
Ckm
creatine kinase, muscle
chr2_-_151458299 8.027 Snph
syntaphilin
chr6_-_92484838 7.679 NM_001134459
Prickle2
prickle homolog 2 (Drosophila)
chr11_-_55233339 7.496 Sparc
secreted acidic cysteine rich glycoprotein
chr12_+_80130149 7.431 NM_181073
Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr7_-_149276174 7.232 NM_008748
Dusp8
dual specificity phosphatase 8
chr2_+_70400179 7.217 NM_008077
Gad1
glutamic acid decarboxylase 1
chr2_-_151458256 6.996 NM_198214
Snph
syntaphilin
chr6_+_86578225 6.948 Asprv1
aspartic peptidase, retroviral-like 1
chr6_+_86578167 6.930 NM_026414
Asprv1
aspartic peptidase, retroviral-like 1
chr15_-_12479631 6.857 Pdzd2
PDZ domain containing 2
chr7_+_149628285 6.768 NM_009405
Tnni2
troponin I, skeletal, fast 2
chr9_-_91259829 6.547 Zic1
zinc finger protein of the cerebellum 1
chr1_-_175266945 6.497 Cadm3
cell adhesion molecule 3
chr7_+_149684731 6.302 NM_001163664
NM_001163665
NM_001163666
NM_001163667
NM_001163668
NM_001163669
NM_001163670
NM_011620
Tnnt3







troponin T3, skeletal, fast







chr16_+_96689373 6.292 Pcp4
Purkinje cell protein 4
chr18_-_33623069 6.265 NM_001109990
D0H4S114
DNA segment, human D4S114
chr7_+_31844947 6.029 NM_144556
Lgi4
leucine-rich repeat LGI family, member 4
chr13_+_48356795 6.015 NM_031166
Id4
inhibitor of DNA binding 4
chr5_-_75098910 5.985 NM_001159577
Lnx1
ligand of numb-protein X 1
chr6_+_5675638 5.941 NM_001191023
NM_001191025
NM_001191026
NM_001191027
NM_010063
Dync1i1




dynein cytoplasmic 1 intermediate chain 1




chrX_-_16394443 5.888 NM_172778
Maob
monoamine oxidase B
chr8_-_74035667 5.850 NM_032398
Plvap
plasmalemma vesicle associated protein
chr14_+_56130147 5.831 NM_009947
Cpne6
copine VI
chr1_-_89470442 5.772 NM_001111314
Ngef
neuronal guanine nucleotide exchange factor
chr13_-_3803547 5.761 NM_027416
Calml3
calmodulin-like 3
chr10_-_76188683 5.729 NM_009933
Col6a1
collagen, type VI, alpha 1
chr7_-_107805466 5.729 NM_001163186
NM_001163187
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_-_174221511 5.711 Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_+_52845510 5.600 Lhfp
lipoma HMGIC fusion partner
chr13_+_48356487 5.456 Id4
inhibitor of DNA binding 4
chr15_+_99421458 5.391 NM_009701
Aqp5
aquaporin 5
chr1_+_58086831 5.378 Aox1
aldehyde oxidase 1
chr5_+_137729501 5.348 NM_009599
Ache
acetylcholinesterase
chr1_+_155747072 5.235 NM_008131
Glul
glutamate-ammonia ligase (glutamine synthetase)
chr1_-_132359292 5.197 NM_010016
Cd55
CD55 antigen
chr15_-_78034565 5.161 NM_013645
Pvalb
parvalbumin
chr1_-_175297624 4.987 Cadm3
cell adhesion molecule 3
chr1_+_58086804 4.955 NM_009676
Aox1
aldehyde oxidase 1
chr4_+_137263376 4.937 Rap1gap
Rap1 GTPase-activating protein
chr15_-_101510717 4.922 NM_010669
Krt6b
keratin 6B
chrX_-_92361694 4.897 Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
chr9_+_21741435 4.866 BC018242
cDNA sequence BC018242
chrX_-_92361778 4.847 NM_001033329
Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
chr8_-_37631532 4.833 Dlc1
deleted in liver cancer 1
chr7_-_133606586 4.691 NM_007504
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr12_+_118997623 4.651 Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr6_+_115085096 4.632 Syn2
synapsin II
chr5_+_136514548 4.595 Upk3b
uroplakin 3B
chr2_+_55288297 4.530 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr7_-_133606617 4.508 Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr11_-_116515602 4.445 NM_030206
Cygb
cytoglobin
chr14_-_55544648 4.436 Efs
embryonal Fyn-associated substrate
chr1_-_133964541 4.435 NM_001114662
NM_172510
Mfsd4

major facilitator superfamily domain containing 4

chr9_+_27598853 4.423 NM_177906
Opcml
opioid binding protein/cell adhesion molecule-like
chr18_+_45719732 4.399 NM_080465
Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr10_+_18564932 4.339 Perp
PERP, TP53 apoptosis effector
chr14_+_56129440 4.334 Cpne6
copine VI
chr3_-_116671869 4.334 NM_023245
Palmd
palmdelphin
chr15_+_101974978 4.290 Igfbp6
insulin-like growth factor binding protein 6
chr2_-_178149153 4.151 NM_001085501
Ppp1r3d
protein phosphatase 1, regulatory subunit 3D
chrX_+_132567905 4.138 NM_029541
6530401D17Rik
RIKEN cDNA 6530401D17 gene
chr6_+_141472906 4.132 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr18_-_43552694 4.131 NM_009468
Dpysl3
dihydropyrimidinase-like 3
chr5_+_136514365 4.088 NM_175309
Upk3b
uroplakin 3B
chr8_-_74035629 4.070 Plvap
plasmalemma vesicle associated protein
chr9_-_37360141 4.068 NM_022029
Nrgn
neurogranin
chr8_+_128519001 3.993 NM_008430
Kcnk1
potassium channel, subfamily K, member 1
chr16_+_96689322 3.975


chr18_-_33623400 3.973 NM_001109989
D0H4S114
DNA segment, human D4S114
chr18_-_33623287 3.961 NM_053078
D0H4S114
DNA segment, human D4S114
chr7_-_148615247 3.931 NM_021316
Cend1
cell cycle exit and neuronal differentiation 1
chr9_-_62384483 3.918 Coro2b
coronin, actin binding protein, 2B
chr16_+_35001358 3.901 Mylk
myosin, light polypeptide kinase
chr7_-_107805365 3.893 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr15_+_99548011 3.863 Gpd1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr5_+_75971011 3.828 NM_001122733
NM_021099
Kit

kit oncogene

chr8_-_37631772 3.825 Dlc1
deleted in liver cancer 1
chr10_+_111708176 3.822 NM_001025581
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr14_-_55544348 3.800 Efs
embryonal Fyn-associated substrate
chr8_+_128519295 3.784 Kcnk1
potassium channel, subfamily K, member 1
chr3_+_68376289 3.758 NM_013928
Schip1
schwannomin interacting protein 1
chr2_-_177691943 3.754 NM_001190302
Gm14326
predicted gene 14326
chr6_-_142519807 3.749 NM_008428
Kcnj8
potassium inwardly-rectifying channel, subfamily J, member 8
chrX_+_132528317 3.716 NM_029823
6530401D17Rik
2900062L11Rik
RIKEN cDNA 6530401D17 gene
RIKEN cDNA 2900062L11 gene
chr17_-_56144975 3.663 NM_145934
Stap2
signal transducing adaptor family member 2
chr7_-_149763600 3.654 H19
H19 fetal liver mRNA
chr14_-_30534966 3.649 NM_009785
Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
chr5_+_14514906 3.648 NM_001110796
NM_011995
Pclo

piccolo (presynaptic cytomatrix protein)

chr2_+_175868350 3.642 NM_001164689
NM_001099308
NM_001177480
Gm6710
Gm14391

predicted gene 6710
predicted gene 14391

chr11_-_11832366 3.609 Grb10
growth factor receptor bound protein 10
chr2_-_175032305 3.602 NM_001164689
NM_001099308
NM_001177480
Gm6710
Gm14391

predicted gene 6710
predicted gene 14391

chr9_+_120213190 3.584 NM_144557
Myrip
myosin VIIA and Rab interacting protein
chr11_+_16157685 3.568 NM_145967
Vstm2a
V-set and transmembrane domain containing 2A
chr9_-_49311823 3.562 Ncam1
neural cell adhesion molecule 1
chr7_+_112706171 3.558 Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr2_+_49474840 3.532 Kif5c
kinesin family member 5C
chr2_+_164312023 3.520 Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr15_+_38837818 3.506 NM_001162494
Fzd6
frizzled homolog 6 (Drosophila)
chr13_+_25035020 3.478 NM_008156
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr15_+_82105322 3.468 NM_011889
Sept3
septin 3
chr18_+_36508277 3.395 NM_001081365
0610010O12Rik
RIKEN cDNA 0610010O12 gene
chr11_+_89891661 3.395 NM_026433
Tmem100
transmembrane protein 100
chr17_+_27822162 3.392 NM_178365
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr8_-_106966899 3.368 NM_001013380
Dync1li2
dynein, cytoplasmic 1 light intermediate chain 2
chr15_+_99548019 3.337 NM_010271
Gpd1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr6_+_34548512 3.312 Cald1
caldesmon 1
chr2_+_128604653 3.305 Mertk
c-mer proto-oncogene tyrosine kinase
chr10_+_52410306 3.304 NM_178675
Slc35f1
solute carrier family 35, member F1
chr4_+_149022266 3.275


chr4_-_150482562 3.266 Camta1
calmodulin binding transcription activator 1
chr2_+_158201373 3.263 NM_175692
Snhg11
small nucleolar RNA host gene 11
chr6_-_92431385 3.262 NM_001134460
Prickle2
prickle homolog 2 (Drosophila)
chr15_+_101933364 3.262 NM_153533
Tenc1
tensin like C1 domain-containing phosphatase
chr7_-_56103405 3.255 NM_001198841
Csrp3
cysteine and glycine-rich protein 3
chr7_-_56103389 3.234 Csrp3
cysteine and glycine-rich protein 3
chr14_+_31692725 3.230 Mustn1
musculoskeletal, embryonic nuclear protein 1
chr1_-_36592571 3.228 NM_153502
Ankrd23
ankyrin repeat domain 23
chr18_+_65183342 3.209 Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr5_+_137994744 3.196 NM_031404
Actl6b
actin-like 6B
chr1_+_66515003 3.188 NM_175510
Unc80
unc-80 homolog (C. elegans)
chr9_-_53822931 3.155 Elmod1
ELMO domain containing 1
chr9_-_75458865 3.147 Tmod2
tropomodulin 2
chr14_-_122138082 3.146 NM_001128307
NM_001128308
Dock9

dedicator of cytokinesis 9

chrX_-_61530035 3.127 Slitrk4
SLIT and NTRK-like family, member 4
chr17_-_34880784 3.113 NM_009780
C4b
complement component 4B (Childo blood group)
chr9_+_122481617 3.087 9530059O14Rik
RIKEN cDNA 9530059O14 gene
chr18_+_58038278 3.086 NM_009194
Slc12a2
solute carrier family 12, member 2
chr5_-_114250360 3.058 NM_146162
Tmem119
transmembrane protein 119
chr3_+_28162135 3.045 NM_001163007
NM_001163008
NM_001163009
NM_026910
Tnik



TRAF2 and NCK interacting kinase



chr15_+_78744328 3.038 NM_020271
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr11_-_18918923 3.035 NM_001193271
NM_010789
Meis1

Meis homeobox 1

chr12_+_30687597 3.027 Pxdn
peroxidasin homolog (Drosophila)
chr8_+_12949417 3.025 NM_001159485
NM_001159486
Mcf2l

mcf.2 transforming sequence-like

chr1_+_196446049 3.016 Plxna2
plexin A2
chr6_+_113421480 2.974 Il17rc
interleukin 17 receptor C
chr12_-_104594210 2.966 NM_023049
Asb2
ankyrin repeat and SOCS box-containing 2
chr2_-_168559743 2.922 Atp9a
ATPase, class II, type 9A
chr3_-_53461276 2.912 NM_172862
Frem2
Fras1 related extracellular matrix protein 2
chr10_-_24919916 2.884 Akap7
A kinase (PRKA) anchor protein 7
chr1_-_132359220 2.872 Cd55
CD55 antigen
chr15_+_102807462 2.869 NM_008272
Hoxc9
homeobox C9
chr1_+_89160921 2.867 NM_028889
Efhd1
EF hand domain containing 1
chr9_+_36640268 2.850 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr3_+_68376319 2.843 Schip1
schwannomin interacting protein 1
chr2_+_35413977 2.842 NM_001114125
Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr8_+_32200076 2.840 NM_025869
Dusp26
dual specificity phosphatase 26 (putative)
chr7_+_35971403 2.799 NM_017394
Slc7a10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chr11_-_96805092 2.788 Pnpo
pyridoxine 5'-phosphate oxidase
chr17_-_24670527 2.783 NM_177375
Rab26
RAB26, member RAS oncogene family
chr15_-_101543318 2.782 NM_027011
Krt5
keratin 5
chr8_+_115093942 2.781 NM_130457
Cntnap4
contactin associated protein-like 4
chr18_+_45719464 2.774 Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr11_-_96805259 2.755 Pnpo
pyridoxine 5'-phosphate oxidase
chr3_+_133903056 2.738 NM_001004367
Cxxc4
CXXC finger 4
chr2_-_120139738 2.735 NM_001024145
Pla2g4f
phospholipase A2, group IVF
chr8_+_59934719 2.697 NM_009136
Scrg1
scrapie responsive gene 1
chr9_+_50561315 2.690 Cryab
crystallin, alpha B
chr11_+_61298923 2.688 NM_029568
Mfap4
microfibrillar-associated protein 4
chr10_+_45009110 2.685 NM_024286
Popdc3
popeye domain containing 3
chr17_+_75835208 2.682 NM_001166493
Rasgrp3
RAS, guanyl releasing protein 3
chr11_-_99354417 2.675 NM_033373
Krt23
keratin 23
chr18_-_25637786 2.658 Celf4
CUGBP, Elav-like family member 4
chr1_-_175297778 2.647 NM_053199
Cadm3
cell adhesion molecule 3
chr3_+_108086993 2.640 Sort1
sortilin 1
chrX_+_54043764 2.636 Fhl1
four and a half LIM domains 1
chr7_-_149763980 2.624 H19
H19 fetal liver mRNA
chr9_-_56483379 2.619 Lingo1
leucine rich repeat and Ig domain containing 1
chrX_+_132373572 2.613 NM_001163015
NM_001163016
NM_001163017
Gprasp2


G protein-coupled receptor associated sorting protein 2


chr2_+_93027792 2.611 Trp53i11
transformation related protein 53 inducible protein 11
chr11_+_61298978 2.610 Mfap4
microfibrillar-associated protein 4
chr11_-_116515361 2.608 Cygb
cytoglobin
chr7_-_133839152 2.583 NM_029420
Slx1b
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr2_-_174967487 2.558 Gm14399
predicted gene 14399
chr7_-_31911754 2.553 Scn1b
sodium channel, voltage-gated, type I, beta
chr11_-_97883924 2.548 NM_001159319
NM_031173
NM_145121
Cacnb1


calcium channel, voltage-dependent, beta 1 subunit


chr4_+_43888373 2.543 NM_016678
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr11_-_96805294 2.539 NM_134021
Pnpo
pyridoxine 5'-phosphate oxidase
chr5_+_14514975 2.534 Pclo
piccolo (presynaptic cytomatrix protein)
chr10_+_18564876 2.525 NM_022032
Perp
PERP, TP53 apoptosis effector
chr11_-_99354449 2.525 Krt23
keratin 23
chr2_-_25095376 2.521 NM_026415
2310002J15Rik
RIKEN cDNA 2310002J15 gene
chr17_+_43804373 2.466 NM_018887
Cyp39a1
cytochrome P450, family 39, subfamily a, polypeptide 1
chr8_+_122223908 2.458 NM_026922
Atp2c2
ATPase, Ca++ transporting, type 2C, member 2
chr11_-_4060222 2.455 NM_001164620
NM_177616
Ccdc157

coiled-coil domain containing 157

chr11_-_30549383 2.451 NM_029344
Acyp2
acylphosphatase 2, muscle type

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.42 2.89e-08 GO:0006810 transport
1.37 3.69e-08 GO:0051179 localization
1.44 3.78e-08 GO:0048731 system development
1.40 1.22e-07 GO:0048856 anatomical structure development
1.40 1.36e-07 GO:0051234 establishment of localization
2.26 5.91e-07 GO:0019226 transmission of nerve impulse
2.26 5.91e-07 GO:0035637 multicellular organismal signaling
1.54 3.05e-06 GO:0023051 regulation of signaling
1.59 5.00e-06 GO:0007399 nervous system development
1.63 6.45e-06 GO:0035556 intracellular signal transduction
1.33 7.27e-06 GO:0032502 developmental process
2.34 7.53e-06 GO:0007268 synaptic transmission
1.34 1.11e-05 GO:0007275 multicellular organismal development
1.67 3.07e-05 GO:0048468 cell development
1.77 4.57e-05 GO:0007154 cell communication
1.48 5.14e-05 GO:0051239 regulation of multicellular organismal process
1.39 1.18e-04 GO:0048869 cellular developmental process
3.04 1.75e-04 GO:0035023 regulation of Rho protein signal transduction
1.39 1.94e-04 GO:0030154 cell differentiation
3.38 3.07e-04 GO:0001505 regulation of neurotransmitter levels
1.47 3.70e-04 GO:0009653 anatomical structure morphogenesis
1.96 7.31e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.61 7.38e-04 GO:0022008 neurogenesis
1.88 9.97e-04 GO:0007267 cell-cell signaling
1.38 1.61e-03 GO:0065008 regulation of biological quality
4.06 1.65e-03 GO:0007269 neurotransmitter secretion
1.61 1.70e-03 GO:0048699 generation of neurons
1.48 2.14e-03 GO:0009966 regulation of signal transduction
1.51 2.86e-03 GO:0032879 regulation of localization
1.83 4.47e-03 GO:0044057 regulation of system process
2.09 4.63e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.54 5.81e-03 GO:2000026 regulation of multicellular organismal development
2.15 5.96e-03 GO:0046578 regulation of Ras protein signal transduction
1.85 6.81e-03 GO:0048729 tissue morphogenesis
1.90 8.56e-03 GO:0001944 vasculature development
1.55 9.38e-03 GO:0006811 ion transport
1.70 1.09e-02 GO:0072358 cardiovascular system development
1.70 1.09e-02 GO:0072359 circulatory system development
1.83 1.19e-02 GO:0051960 regulation of nervous system development
1.46 1.32e-02 GO:0010646 regulation of cell communication
1.78 1.57e-02 GO:0060284 regulation of cell development
1.95 2.03e-02 GO:0007264 small GTPase mediated signal transduction
2.01 2.09e-02 GO:0048514 blood vessel morphogenesis
1.86 2.22e-02 GO:0031175 neuron projection development
1.74 2.71e-02 GO:0048666 neuron development
1.65 3.23e-02 GO:0030182 neuron differentiation
2.70 3.56e-02 GO:0006836 neurotransmitter transport
1.58 4.79e-02 GO:0022610 biological adhesion

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.27 6.35e-18 GO:0005737 cytoplasm
1.47 1.99e-17 GO:0005886 plasma membrane
1.46 7.74e-17 GO:0071944 cell periphery
2.36 2.96e-16 GO:0043005 neuron projection
1.80 8.27e-12 GO:0042995 cell projection
1.29 5.46e-11 GO:0044444 cytoplasmic part
1.21 2.02e-10 GO:0016020 membrane
2.51 1.52e-09 GO:0030425 dendrite
1.15 3.21e-09 GO:0005622 intracellular
1.14 1.21e-07 GO:0044424 intracellular part
1.48 1.44e-07 GO:0044459 plasma membrane part
2.41 1.81e-07 GO:0030424 axon
1.99 2.12e-07 GO:0045202 synapse
1.08 8.46e-07 GO:0005623 cell
1.08 8.46e-07 GO:0044464 cell part
2.02 1.58e-06 GO:0044463 cell projection part
2.97 3.10e-06 GO:0043292 contractile fiber
1.55 5.02e-06 GO:0000267 cell fraction
1.63 5.86e-06 GO:0005626 insoluble fraction
2.08 6.47e-06 GO:0044297 cell body
1.60 1.61e-05 GO:0005794 Golgi apparatus
2.94 1.94e-05 GO:0030016 myofibril
4.71 2.14e-05 GO:0043198 dendritic shaft
3.16 3.17e-05 GO:0030017 sarcomere
1.46 3.20e-05 GO:0005856 cytoskeleton
2.05 3.43e-05 GO:0043025 neuronal cell body
1.70 9.21e-05 GO:0030054 cell junction
1.56 2.40e-04 GO:0005624 membrane fraction
2.77 5.33e-04 GO:0044449 contractile fiber part
1.88 1.23e-03 GO:0044456 synapse part
2.83 3.79e-03 GO:0042383 sarcolemma
1.91 3.98e-03 GO:0015629 actin cytoskeleton
1.11 4.17e-03 GO:0043229 intracellular organelle
2.37 5.35e-03 GO:0033267 axon part
1.11 5.49e-03 GO:0043226 organelle
1.52 6.58e-03 GO:0031982 vesicle
3.63 1.11e-02 GO:0042734 presynaptic membrane
1.52 1.19e-02 GO:0031410 cytoplasmic vesicle
2.66 1.60e-02 GO:0030427 site of polarized growth
2.76 2.34e-02 GO:0043197 dendritic spine
2.62 3.07e-02 GO:0030426 growth cone
2.68 3.43e-02 GO:0044309 neuron spine
2.44 3.90e-02 GO:0016327 apicolateral plasma membrane
1.12 4.96e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.29 5.08e-12 GO:0005515 protein binding
1.15 1.73e-08 GO:0005488 binding
2.44 2.65e-07 GO:0005083 small GTPase regulator activity
1.90 3.42e-06 GO:0008092 cytoskeletal protein binding
1.84 6.33e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.84 9.35e-04 GO:0030695 GTPase regulator activity
1.57 1.53e-03 GO:0022891 substrate-specific transmembrane transporter activity
2.24 2.46e-03 GO:0005244 voltage-gated ion channel activity
2.24 2.46e-03 GO:0022832 voltage-gated channel activity
1.69 2.62e-03 GO:0005509 calcium ion binding
2.97 2.82e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
3.06 2.87e-03 GO:0019199 transmembrane receptor protein kinase activity
1.50 6.77e-03 GO:0022857 transmembrane transporter activity
3.09 7.31e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.56 8.06e-03 GO:0015075 ion transmembrane transporter activity
1.33 8.94e-03 GO:0032553 ribonucleotide binding
1.32 1.24e-02 GO:0032555 purine ribonucleotide binding
1.32 1.59e-02 GO:0017076 purine nucleotide binding
1.83 1.90e-02 GO:0003779 actin binding
1.46 2.01e-02 GO:0022892 substrate-specific transporter activity
1.31 2.14e-02 GO:0035639 purine ribonucleoside triphosphate binding
2.30 2.25e-02 GO:0022843 voltage-gated cation channel activity
1.85 2.38e-02 GO:0022836 gated channel activity
3.03 2.98e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.41 3.20e-02 GO:0005215 transporter activity
1.21 3.37e-02 GO:0043169 cation binding
6.02 3.40e-02 GO:0030675 Rac GTPase activator activity
1.51 3.49e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.61 3.95e-02 GO:0008324 cation transmembrane transporter activity
11.17 4.52e-02 GO:0005030 neurotrophin receptor activity
1.20 4.56e-02 GO:0043167 ion binding