• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: SPIB.p2

Z-value: 5.102

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrX_-_7667574	148.775	NM_009515	Was	Wiskott-Aldrich syndrome homolog (human)
chrX_-_98463514	115.469	NM_013563	Il2rg	interleukin 2 receptor, gamma chain
chr15_+_103284200	108.781	NM_153505	Nckap1l	NCK associated protein 1 like
chr11_+_33946927	104.727		Lcp2	lymphocyte cytosolic protein 2
chr6_-_136889984	100.687		Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta
chr7_-_52494453	97.591		Cd37	CD37 antigen
chr6_-_136890189	95.027	NM_007486	Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta
chr17_+_34727032	91.535		Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr12_+_99506844	88.519	NM_008152	Gpr65	G-protein coupled receptor 65
chr19_+_10917326	83.710		Slc15a3	solute carrier family 15, member 3
chr7_-_3671918	70.563	NM_011095	Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr19_+_10917005	70.467	NM_023044	Slc15a3	solute carrier family 15, member 3
chr1_-_173164404	66.566	NM_010185	Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide
chr5_+_150076605	66.030	NM_009663	Alox5ap	arachidonate 5-lipoxygenase activating protein
chr17_+_34726750	65.044	NM_134116	Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr7_+_133728451	64.566		Apobr	apolipoprotein B receptor
chr11_+_33947115	63.862	NM_010696	Lcp2	lymphocyte cytosolic protein 2
chr17_+_36003527	63.316	NM_175242	2310014H01Rik	RIKEN cDNA 2310014H01 gene
chr7_+_29225955	61.885	NM_001039192	Gmfg	glia maturation factor, gamma
chr2_+_90936845	59.993	NM_011355	Sfpi1	SFFV proviral integration 1
chr11_-_79343891	59.690		Evi2a	ecotropic viral integration site 2a
chr7_-_52494097	59.655	NM_007645	Cd37	CD37 antigen
chr11_+_60955985	59.416		Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b
chr19_+_12873115	58.833		Lpxn	leupaxin
chr11_+_95703598	58.205	NM_023121	Gngt2	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr6_+_123212124	57.590	NM_001163161 NM_010819	Clec4d	C-type lectin domain family 4, member d
chr19_+_12873063	56.723	NM_134152	Lpxn	leupaxin
chr7_+_133728483	56.572	NM_138310	Apobr	apolipoprotein B receptor
chr14_+_75536138	56.560	NM_008879	Lcp1	lymphocyte cytosolic protein 1
chr7_-_133848235	55.258	NM_009898	Coro1a	coronin, actin binding protein 1A
chrX_-_131117602	54.493	NM_013482	Btk	Bruton agammaglobulinemia tyrosine kinase
chr9_+_55937776	53.976	NM_011193	Pstpip1	proline-serine-threonine phosphatase-interacting protein 1
chr9_+_107885355	52.908	NM_177090	Cdh29 Uba7	cadherin-like 29 ubiquitin-like modifier activating enzyme 7
chr9_+_55937980	52.522		Pstpip1	proline-serine-threonine phosphatase-interacting protein 1
chr15_-_82863658	51.750		Nfam1	Nfat activating molecule with ITAM motif 1
chr6_-_123239765	51.736		Clec4e	C-type lectin domain family 4, member e
chr11_+_95703981	51.012	NM_001038664	Gngt2	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr15_-_66644127	50.689	NM_009192	Sla	src-like adaptor
chrX_-_9046362	50.592	NM_007807	Cybb	cytochrome b-245, beta polypeptide
chr2_+_103810274	48.937	NM_001142335 NM_008505	Lmo2	LIM domain only 2
chr2_-_25052129	48.485		A830007P12Rik	RIKEN cDNA A830007P12 gene
chr17_+_33692639	48.416	NM_053214	Myo1f	myosin IF
chr12_-_32893074	47.433	NM_001146201 NM_020272 NM_001146200	Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr11_-_79337178	46.259		Evi2b	ecotropic viral integration site 2b
chr7_-_31827099	45.812	NM_008761	Fxyd5	FXYD domain-containing ion transport regulator 5
chr16_+_36935029	44.803	NM_008225	Hcls1	hematopoietic cell specific Lyn substrate 1
chr19_-_6932673	44.296	NM_001081291	Ccdc88b	coiled-coil domain containing 88B
chr6_+_123212210	43.974		Clec4d	C-type lectin domain family 4, member d
chr7_-_31826775	43.525	NM_001111073	Fxyd5	FXYD domain-containing ion transport regulator 5
chr19_+_10917432	42.654		Slc15a3	solute carrier family 15, member 3
chr10_+_126760748	41.867	NM_146011	Arhgap9	Rho GTPase activating protein 9
chr19_-_41459518	41.854	NM_031376	Pik3ap1	phosphoinositide-3-kinase adaptor protein 1
chr8_+_87225355	41.503	NM_008535	Lyl1	lymphoblastomic leukemia 1
chr11_+_83476085	41.208	NM_013652	Ccl4	chemokine (C-C motif) ligand 4
chr11_-_79344055	41.017	NM_001033711 NM_010161 NM_146023	Evi2a Evi2b	ecotropic viral integration site 2a ecotropic viral integration site 2b
chr7_+_26472573	40.474		Tgfb1	transforming growth factor, beta 1
chr19_+_12535536	40.281		Mpeg1	macrophage expressed gene 1
chr2_+_152934184	40.077	NM_001172117 NM_010407	Hck	hemopoietic cell kinase
chr7_+_26472526	40.059		Tgfb1	transforming growth factor, beta 1
chr11_-_69479553	39.924	NM_009853	Cd68	CD68 antigen
chr7_+_150191542	39.767	NM_001128081 NM_001128082 NM_020286	Tspan32	tetraspanin 32
chr5_-_134705423	39.674	NM_010876	Ncf1	neutrophil cytosolic factor 1
chr7_-_3867085	39.445	NM_011087 NM_011090	Pira1 Lilra6	paired-Ig-like receptor A1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chrX_-_20508314	39.437		Cfp	complement factor properdin
chr1_-_80661844	38.950		Dock10	dedicator of cytokinesis 10
chr16_-_19983049	38.473	NM_183390	Klhl6	kelch-like 6 (Drosophila)
chr11_-_95703752	38.284	NM_025659 NM_001163464	Abi3	ABI gene family, member 3
chr9_+_20820403	38.101	NM_010493	Icam1	intercellular adhesion molecule 1
chr1_+_175561105	37.843		Pyhin1	pyrin and HIN domain family, member 1
chr9_-_57493393	37.713		Csk	c-src tyrosine kinase
chr15_-_66644199	37.708		Sla	src-like adaptor
chr1_+_154654953	37.355	NM_010877	Ncf2	neutrophil cytosolic factor 2
chr5_-_65324796	36.691		Tlr1	toll-like receptor 1
chr6_-_123239886	36.675	NM_019948	Clec4e	C-type lectin domain family 4, member e
chr1_+_52065469	36.617		Stat4	signal transducer and activator of transcription 4
chr1_+_89516886	36.449	NM_001110192 NM_001110193 NM_010566	Inpp5d	inositol polyphosphate-5-phosphatase D
chr10_-_18731766	36.305	NM_001166402	Tnfaip3	tumor necrosis factor, alpha-induced protein 3
chr15_-_66392539	36.137	NM_172514	Tmem71	transmembrane protein 71
chr3_-_94946256	36.030	NM_027206	Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2
chr11_+_68245608	35.419	NM_177320	Pik3r5	phosphoinositide-3-kinase, regulatory subunit 5, p101
chr2_-_181426495	34.984		Rgs19	regulator of G-protein signaling 19
chr7_+_26471968	34.930	NM_011577	Tgfb1	transforming growth factor, beta 1
chr9_-_66767436	34.846	NM_173413	Rab8b	RAB8B, member RAS oncogene family
chr3_-_58905678	34.583	NM_173398	Gpr171	G protein-coupled receptor 171
chr2_+_24201033	34.156		Il1rn	interleukin 1 receptor antagonist
chr18_-_35900005	33.923	NM_028261	Tmem173	transmembrane protein 173
chr17_+_50648736	33.783	NM_013880	Plcl2	phospholipase C-like 2
chrX_-_20508584	33.765	NM_008823	Cfp	complement factor properdin
chr6_-_87446228	33.278	NM_175476	Arhgap25	Rho GTPase activating protein 25
chr6_+_145070255	33.223	NM_008511	Lrmp	lymphoid-restricted membrane protein
chr15_+_78156227	32.679	NM_007780	Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr16_+_45224449	32.353	NM_001037719 NM_177584	Btla	B and T lymphocyte associated
chr6_+_29479250	31.896		Irf5	interferon regulatory factor 5
chr11_-_69709003	31.572	NM_153788	Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr2_-_25483461	31.463	NM_007995	Fcna	ficolin A
chr1_-_133096633	30.880		Rassf5	Ras association (RalGDS/AF-6) domain family member 5
chr11_-_79337251	30.817	NM_001077496	Evi2b	ecotropic viral integration site 2b
chr1_-_140071630	30.738		Ptprc	protein tyrosine phosphatase, receptor type, C
chr11_-_23670766	30.584	NM_009044	Rel	reticuloendotheliosis oncogene
chr17_-_57217861	30.510	NM_153551	Dennd1c	DENN/MADD domain containing 1C
chr10_-_10277885	30.455	NM_026405	Rab32	RAB32, member RAS oncogene family
chr5_-_138312923	30.435	NM_001024932	Pilrb2	paired immunoglobin-like type 2 receptor beta 2
chr9_+_5298516	30.203	NM_009807	Casp1	caspase 1
chrX_+_155693729	30.156		Rps6ka3	ribosomal protein S6 kinase polypeptide 3
chr13_-_55122556	29.952		Hk3	hexokinase 3
chr1_-_195027508	28.831	NM_153137	Traf3ip3	TRAF3 interacting protein 3
chr8_+_68910191	28.778	NM_001166375	March1	membrane-associated ring finger (C3HC4) 1
chr11_-_106243873	28.741	NM_010494	Icam2	intercellular adhesion molecule 2
chr16_-_32079317	28.691	NM_177326	Pak2	p21 protein (Cdc42/Rac)-activated kinase 2
chr2_+_24200925	28.512		Il1rn	interleukin 1 receptor antagonist
chr1_+_52065087	28.179	NM_011487	Stat4	signal transducer and activator of transcription 4
chr2_+_24200890	28.026	NM_001039701	Il1rn	interleukin 1 receptor antagonist
chr1_-_54983211	27.978	NM_001081433	Ankrd44	ankyrin repeat domain 44
chr2_+_24200807	27.947	NM_001159562	Il1rn	interleukin 1 receptor antagonist
chr17_+_28344722	27.910	NM_027185	Def6	differentially expressed in FDCP 6
chrX_+_104344792	27.870	NM_001122595	A630033H20Rik	RIKEN cDNA A630033H20 gene
chr3_-_20142068	27.744	NM_007753	Cpa3	carboxypeptidase A3, mast cell
chr16_+_52031704	27.229		Cblb	Casitas B-lineage lymphoma b
chr2_-_31939210	27.171	NM_175511	Fam78a	family with sequence similarity 78, member A
chr8_+_3665753	26.984	NM_026985	1810033B17Rik	RIKEN cDNA 1810033B17 gene
chr11_-_48805585	26.860	NM_001145164 NM_011579	Tgtp2 Tgtp1 Gm12185	T-cell specific GTPase 2 T-cell specific GTPase 1 predicted gene 12185
chr11_-_34597324	26.842	NM_033374	Dock2	dedicator of cyto-kinesis 2
chr11_+_61466766	26.811		Grap	GRB2-related adaptor protein
chr6_-_16848352	26.797	NM_031198	Tcfec	transcription factor EC
chr10_+_67000613	26.792	NM_010118	Egr2	early growth response 2
chr10_-_80962400	26.778		S1pr4	sphingosine-1-phosphate receptor 4
chr3_-_135354151	26.772		Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr11_+_61466797	26.705	NM_027817	Grap	GRB2-related adaptor protein
chr13_-_56279929	26.634		Tifab	TRAF-interacting protein with forkhead-associated domain, family member B
chr6_+_122902755	26.553		Clec4a3	C-type lectin domain family 4, member a3
chr13_-_55122654	26.388		Hk3	hexokinase 3
chr10_-_80962881	26.252	NM_010102	S1pr4	sphingosine-1-phosphate receptor 4
chr9_-_57492978	25.890	NM_007783	Csk	c-src tyrosine kinase
chr19_-_3903069	25.843		Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
chr4_+_130469048	25.807		Laptm5	lysosomal-associated protein transmembrane 5
chr11_-_16908631	25.697	NM_019549	Plek	pleckstrin
chr14_-_20796255	25.512		Gng2	guanine nucleotide binding protein (G protein), gamma 2
chr4_-_106812064	25.314		2210012G02Rik	RIKEN cDNA 2210012G02 gene
chrX_+_104344953	25.281	NM_175442	A630033H20Rik	RIKEN cDNA A630033H20 gene
chr13_-_55122670	25.270	NM_001033245	Hk3	hexokinase 3
chr16_-_32165509	25.249	NM_146069	Lrrc33	leucine rich repeat containing 33
chr12_-_56087322	25.218	NM_013815	Baz1a	bromodomain adjacent to zinc finger domain 1A
chr17_+_57498108	25.071	NM_010130	Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr4_+_155400430	25.069	NM_009400 NM_021985	Tnfrsf18	tumor necrosis factor receptor superfamily, member 18
chr1_-_54983048	25.039		Ankrd44	ankyrin repeat domain 44
chr6_-_124683046	24.964	NM_013545	Ptpn6	protein tyrosine phosphatase, non-receptor type 6
chr4_+_130469187	24.904	NM_010686	Laptm5	lysosomal-associated protein transmembrane 5
chr6_+_123179860	24.431	NM_001190320 NM_001190321 NM_020001	Clec4n	C-type lectin domain family 4, member n
chr3_+_90070455	24.291	NM_201407	Dennd4b	DENN/MADD domain containing 4B
chr1_+_172949069	24.241		Fcgr4	Fc receptor, IgG, low affinity IV
chr1_+_172949049	24.140	NM_144559	Fcgr4	Fc receptor, IgG, low affinity IV
chr6_+_83276009	24.119	NM_145571	Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)
chr7_+_142843598	24.003		Ptpre	protein tyrosine phosphatase, receptor type, E
chr15_-_42508294	23.985	NM_009640	Angpt1	angiopoietin 1
chr16_+_44765848	23.985	NM_021325	Cd200r1	CD200 receptor 1
chr15_+_6529846	23.865	NM_011815	Fyb	FYN binding protein
chr1_+_175560938	23.523	NM_175026	Pyhin1	pyrin and HIN domain family, member 1
chr15_-_78136032	23.506	NM_007781	Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr6_+_123073333	23.394	NM_001170333 NM_011999	Clec4a2	C-type lectin domain family 4, member a2
chr8_-_26212614	23.392		Plekha2	pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr12_+_77471506	23.263		Zbtb1	zinc finger and BTB domain containing 1
chr5_+_34886013	23.182	NM_001145858	Sh3bp2	SH3-domain binding protein 2
chr5_-_115119973	23.179		Gltp	glycolipid transfer protein
chr16_-_3976544	23.094	NM_001081280	Nlrc3	NLR family, CARD domain containing 3
chr2_+_43604343	23.028	NM_153820 NM_001025377	Arhgap15	Rho GTPase activating protein 15
chr2_-_25483295	23.020		Fcna	ficolin A
chr14_-_56721304	22.997	NM_007800	Ctsg	cathepsin G
chr7_-_31204764	22.862	NM_011827	Hcst	hematopoietic cell signal transducer
chr2_-_25052245	22.757	NM_146115	A830007P12Rik	RIKEN cDNA A830007P12 gene
chr7_+_108542896	22.750	NM_198096	Arap1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr7_+_31208322	22.741	NM_172142	Nfkbid	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr3_-_135271190	22.624		Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr1_-_146622545	22.559	NM_022881	Rgs18	regulator of G-protein signaling 18
chr6_-_16848314	22.459		Tcfec	transcription factor EC
chr17_+_35400983	22.266		H2-D1	histocompatibility 2, D region locus 1
chr10_+_79479416	22.155	NM_001142701	Hmha1	histocompatibility (minor) HA-1
chr13_+_20182408	22.141		Elmo1	engulfment and cell motility 1, ced-12 homolog (C. elegans)
chr12_+_72149332	22.023		Arid4a	AT rich interactive domain 4A (RBP1-like)
chr13_+_37917957	21.879		Rreb1	ras responsive element binding protein 1
chr4_-_43467398	21.757	NM_001110320 NM_001110321 NM_001110322 NM_007654	Cd72	CD72 antigen
chr8_-_91159932	21.677	NM_027840	Snx20	sorting nexin 20
chr3_-_90499611	21.645	NM_009114	S100a9	S100 calcium binding protein A9 (calgranulin B)
chr10_+_96079634	21.606	NM_007569	Btg1	B-cell translocation gene 1, anti-proliferative
chr5_-_138277478	21.528	NM_153510	Pilra	paired immunoglobin-like type 2 receptor alpha
chr6_-_124688630	21.488	NM_001077705	Ptpn6	protein tyrosine phosphatase, non-receptor type 6
chr19_+_12535268	21.428	NM_010821	Mpeg1	macrophage expressed gene 1
chr9_-_110959905	21.408		Ccrl2	chemokine (C-C motif) receptor-like 2
chr2_-_28477437	21.390	NM_001160406 NM_008114	Gfi1b	growth factor independent 1B
chr5_+_86500770	21.354	NM_019992	Stap1	signal transducing adaptor family member 1
chr19_-_5661634	21.340		Sipa1	signal-induced proliferation associated gene 1
chr8_-_73155445	21.282	NM_011819	Gdf15	growth differentiation factor 15
chr3_-_135271247	21.138		Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr19_-_18706181	21.069		Ostf1	osteoclast stimulating factor 1
chr6_+_38868942	21.027	NM_011539	Tbxas1	thromboxane A synthase 1, platelet
chr11_-_118254729	21.013		Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein
chr17_-_35325354	21.010	NM_010734	Lst1	leukocyte specific transcript 1
chr3_-_135271220	20.851		Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
chr9_+_123428782	20.803		Limd1	LIM domains containing 1
chr7_-_128217980	20.750	NM_030691	Igsf6	immunoglobulin superfamily, member 6
chr3_-_106592919	20.734	NM_007651	Cd53	CD53 antigen

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
2.12	3.37e-52	GO:0002376	immune system process
1.40	2.61e-46	GO:0044260	cellular macromolecule metabolic process
1.36	4.51e-42	GO:0043170	macromolecule metabolic process
1.53	7.08e-40	GO:0090304	nucleic acid metabolic process
1.43	8.29e-38	GO:0031323	regulation of cellular metabolic process
1.28	1.06e-36	GO:0044238	primary metabolic process
1.55	3.20e-36	GO:0016070	RNA metabolic process
1.52	5.80e-36	GO:0010467	gene expression
1.43	7.01e-35	GO:0060255	regulation of macromolecule metabolic process
1.44	8.72e-35	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41	3.35e-34	GO:0080090	regulation of primary metabolic process
1.50	3.65e-34	GO:0010556	regulation of macromolecule biosynthetic process
1.48	9.20e-34	GO:0031326	regulation of cellular biosynthetic process
1.47	1.08e-32	GO:0009889	regulation of biosynthetic process
1.50	1.92e-32	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.48	3.49e-32	GO:0010468	regulation of gene expression
1.37	4.70e-32	GO:0019222	regulation of metabolic process
1.47	6.17e-32	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47	8.59e-32	GO:0051171	regulation of nitrogen compound metabolic process
1.27	1.63e-31	GO:0044237	cellular metabolic process
1.50	7.71e-31	GO:0051252	regulation of RNA metabolic process
1.51	2.99e-30	GO:0006355	regulation of transcription, DNA-dependent
1.37	1.25e-27	GO:0034641	cellular nitrogen compound metabolic process
1.36	2.97e-27	GO:0006807	nitrogen compound metabolic process
1.42	6.37e-26	GO:0048518	positive regulation of biological process
2.25	2.52e-25	GO:0006955	immune response
1.21	1.17e-24	GO:0008152	metabolic process
2.21	1.46e-24	GO:0002684	positive regulation of immune system process
1.44	5.75e-24	GO:0009059	macromolecule biosynthetic process
1.44	1.27e-23	GO:0034645	cellular macromolecule biosynthetic process
1.51	4.88e-22	GO:0032774	RNA biosynthetic process
1.51	5.71e-22	GO:0006351	transcription, DNA-dependent
2.41	6.22e-22	GO:0045321	leukocyte activation
1.91	9.44e-22	GO:0002682	regulation of immune system process
2.21	1.41e-20	GO:0050776	regulation of immune response
2.26	2.29e-20	GO:0001775	cell activation
1.40	4.47e-20	GO:0048522	positive regulation of cellular process
1.39	9.74e-18	GO:0048519	negative regulation of biological process
2.26	2.90e-16	GO:0050778	positive regulation of immune response
1.46	5.16e-16	GO:0048583	regulation of response to stimulus
1.31	1.14e-15	GO:0009058	biosynthetic process
1.31	1.17e-15	GO:0044249	cellular biosynthetic process
2.65	1.65e-15	GO:0002764	immune response-regulating signaling pathway
2.32	2.25e-15	GO:0046649	lymphocyte activation
1.49	2.66e-15	GO:0009893	positive regulation of metabolic process
2.02	4.15e-15	GO:0002520	immune system development
1.10	6.54e-15	GO:0009987	cellular process
1.50	1.67e-14	GO:0010604	positive regulation of macromolecule metabolic process
2.62	1.84e-14	GO:0002757	immune response-activating signal transduction
1.37	1.89e-14	GO:0048523	negative regulation of cellular process
1.48	4.51e-14	GO:0031325	positive regulation of cellular metabolic process
2.00	8.43e-14	GO:0048534	hemopoietic or lymphoid organ development
1.53	1.63e-13	GO:0009892	negative regulation of metabolic process
2.40	2.06e-13	GO:0002253	activation of immune response
1.55	7.55e-13	GO:0010605	negative regulation of macromolecule metabolic process
2.07	1.24e-12	GO:0031347	regulation of defense response
1.55	1.31e-12	GO:0031328	positive regulation of cellular biosynthetic process
1.81	1.79e-12	GO:0080134	regulation of response to stress
1.53	4.79e-12	GO:0031324	negative regulation of cellular metabolic process
1.40	4.98e-12	GO:0006950	response to stress
1.58	5.65e-12	GO:0010628	positive regulation of gene expression
2.36	1.11e-11	GO:0002521	leukocyte differentiation
1.52	1.18e-11	GO:0009891	positive regulation of biosynthetic process
1.59	1.84e-11	GO:0048584	positive regulation of response to stimulus
2.34	2.66e-11	GO:0031349	positive regulation of defense response
1.55	2.81e-11	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.54	3.48e-11	GO:0051173	positive regulation of nitrogen compound metabolic process
1.97	3.70e-11	GO:0030097	hemopoiesis
1.72	4.67e-11	GO:0006952	defense response
2.01	7.43e-11	GO:0001817	regulation of cytokine production
1.53	1.83e-10	GO:0010557	positive regulation of macromolecule biosynthetic process
2.53	2.07e-10	GO:0045089	positive regulation of innate immune response
1.56	3.35e-10	GO:0009890	negative regulation of biosynthetic process
1.57	5.03e-10	GO:0031327	negative regulation of cellular biosynthetic process
2.36	6.08e-10	GO:0045088	regulation of innate immune response
1.48	8.00e-10	GO:0010941	regulation of cell death
1.67	8.09e-10	GO:0006396	RNA processing
1.26	8.40e-10	GO:0071840	cellular component organization or biogenesis
1.31	1.03e-09	GO:0044267	cellular protein metabolic process
1.58	1.45e-09	GO:0051172	negative regulation of nitrogen compound metabolic process
1.47	2.18e-09	GO:0043067	regulation of programmed cell death
1.84	2.59e-09	GO:0051707	response to other organism
1.48	2.93e-09	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.56	3.61e-09	GO:0010558	negative regulation of macromolecule biosynthetic process
1.57	3.65e-09	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.23	4.11e-09	GO:0045087	innate immune response
1.67	4.24e-09	GO:0051704	multi-organism process
1.47	4.40e-09	GO:0042981	regulation of apoptosis
1.57	6.80e-09	GO:0010629	negative regulation of gene expression
1.53	7.44e-09	GO:0045893	positive regulation of transcription, DNA-dependent
1.45	8.75e-09	GO:0035556	intracellular signal transduction
2.22	9.83e-09	GO:0002252	immune effector process
1.52	1.19e-08	GO:0051254	positive regulation of RNA metabolic process
2.20	1.35e-08	GO:0050867	positive regulation of cell activation
2.61	1.49e-08	GO:0002218	activation of innate immune response
2.22	1.52e-08	GO:0002696	positive regulation of leukocyte activation
2.29	1.91e-08	GO:0042110	T cell activation
1.94	2.15e-08	GO:0050865	regulation of cell activation
1.96	2.30e-08	GO:0002694	regulation of leukocyte activation
1.72	2.96e-08	GO:0009607	response to biotic stimulus
2.61	3.60e-08	GO:0002221	pattern recognition receptor signaling pathway
2.01	4.17e-08	GO:0051249	regulation of lymphocyte activation
2.91	4.89e-08	GO:0002756	MyD88-independent toll-like receptor signaling pathway
1.77	5.46e-08	GO:0016071	mRNA metabolic process
2.24	6.26e-08	GO:0051251	positive regulation of lymphocyte activation
1.24	6.92e-08	GO:0016043	cellular component organization
1.53	8.47e-08	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
2.56	1.03e-07	GO:0002758	innate immune response-activating signal transduction
2.63	1.35e-07	GO:0002224	toll-like receptor signaling pathway
2.63	1.35e-07	GO:0042113	B cell activation
1.55	1.50e-07	GO:0051253	negative regulation of RNA metabolic process
1.60	1.54e-07	GO:0051094	positive regulation of developmental process
1.25	1.54e-07	GO:0019538	protein metabolic process
1.35	2.48e-07	GO:0006996	organelle organization
1.31	4.42e-07	GO:0043412	macromolecule modification
1.42	6.79e-07	GO:0032268	regulation of cellular protein metabolic process
2.94	7.53e-07	GO:0002274	myeloid leukocyte activation
1.54	7.93e-07	GO:0045892	negative regulation of transcription, DNA-dependent
2.16	1.03e-06	GO:0001819	positive regulation of cytokine production
1.66	1.36e-06	GO:0045597	positive regulation of cell differentiation
1.72	2.85e-06	GO:0016568	chromatin modification
1.39	2.87e-06	GO:0050793	regulation of developmental process
1.32	3.07e-06	GO:0051239	regulation of multicellular organismal process
2.01	3.61e-06	GO:0002697	regulation of immune effector process
2.59	8.71e-06	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
2.15	9.53e-06	GO:0030098	lymphocyte differentiation
2.39	1.08e-05	GO:0002443	leukocyte mediated immunity
1.43	1.34e-05	GO:0045184	establishment of protein localization
1.29	1.36e-05	GO:0006464	protein modification process
1.55	1.43e-05	GO:0051276	chromosome organization
1.51	1.45e-05	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.34	1.68e-05	GO:0033036	macromolecule localization
1.43	1.82e-05	GO:0045595	regulation of cell differentiation
2.02	2.88e-05	GO:0050863	regulation of T cell activation
2.65	3.00e-05	GO:0002768	immune response-regulating cell surface receptor signaling pathway
2.94	3.48e-05	GO:0002573	myeloid leukocyte differentiation
2.27	3.67e-05	GO:0050870	positive regulation of T cell activation
1.71	3.94e-05	GO:0006397	mRNA processing
1.53	4.25e-05	GO:0010942	positive regulation of cell death
1.46	4.40e-05	GO:0033554	cellular response to stress
1.46	4.45e-05	GO:0070887	cellular response to chemical stimulus
1.53	4.81e-05	GO:0043068	positive regulation of programmed cell death
1.84	4.85e-05	GO:0034097	response to cytokine stimulus
1.80	5.85e-05	GO:0009617	response to bacterium
1.23	5.98e-05	GO:0071841	cellular component organization or biogenesis at cellular level
1.35	7.50e-05	GO:0051246	regulation of protein metabolic process
1.42	8.81e-05	GO:0031399	regulation of protein modification process
1.41	9.15e-05	GO:0015031	protein transport
1.10	9.72e-05	GO:0050789	regulation of biological process
1.71	9.93e-05	GO:0008380	RNA splicing
1.21	1.13e-04	GO:0048856	anatomical structure development
1.38	1.15e-04	GO:2000026	regulation of multicellular organismal development
1.10	1.29e-04	GO:0050794	regulation of cellular process
1.44	1.45e-04	GO:0019220	regulation of phosphate metabolic process
1.44	1.45e-04	GO:0051174	regulation of phosphorus metabolic process
1.09	1.54e-04	GO:0065007	biological regulation
2.35	1.56e-04	GO:0042035	regulation of cytokine biosynthetic process
1.51	1.56e-04	GO:0043065	positive regulation of apoptosis
1.45	1.72e-04	GO:0042325	regulation of phosphorylation
2.20	1.81e-04	GO:0002703	regulation of leukocyte mediated immunity
2.21	1.93e-04	GO:0002699	positive regulation of immune effector process
1.21	2.37e-04	GO:0048731	system development
1.42	2.45e-04	GO:0016265	death
2.10	2.70e-04	GO:0030099	myeloid cell differentiation
1.42	2.83e-04	GO:0008219	cell death
1.94	2.85e-04	GO:0051052	regulation of DNA metabolic process
2.30	3.61e-04	GO:0002250	adaptive immune response
1.31	4.41e-04	GO:0009966	regulation of signal transduction
1.23	4.49e-04	GO:0048869	cellular developmental process
1.60	4.97e-04	GO:0010551	regulation of gene-specific transcription from RNA polymerase II promoter
1.17	5.01e-04	GO:0032502	developmental process
1.89	5.05e-04	GO:0032844	regulation of homeostatic process
1.56	5.19e-04	GO:0006325	chromatin organization
2.99	5.41e-04	GO:0001776	leukocyte homeostasis
2.53	5.53e-04	GO:0002429	immune response-activating cell surface receptor signaling pathway
1.23	6.94e-04	GO:0030154	cell differentiation
2.00	7.16e-04	GO:0010638	positive regulation of organelle organization
1.54	7.81e-04	GO:0032583	regulation of gene-specific transcription
2.59	8.11e-04	GO:0042108	positive regulation of cytokine biosynthetic process
3.02	8.12e-04	GO:0002260	lymphocyte homeostasis
1.54	1.01e-03	GO:0051240	positive regulation of multicellular organismal process
1.92	1.07e-03	GO:0006913	nucleocytoplasmic transport
1.42	1.15e-03	GO:0012501	programmed cell death
1.78	1.24e-03	GO:0016569	covalent chromatin modification
1.26	1.27e-03	GO:0065009	regulation of molecular function
1.36	1.34e-03	GO:0051649	establishment of localization in cell
2.54	1.36e-03	GO:0050871	positive regulation of B cell activation
1.78	1.42e-03	GO:0016570	histone modification
1.44	1.52e-03	GO:0001932	regulation of protein phosphorylation
1.91	1.59e-03	GO:0071345	cellular response to cytokine stimulus
1.34	1.65e-03	GO:0042127	regulation of cell proliferation
2.19	1.71e-03	GO:0002706	regulation of lymphocyte mediated immunity
2.19	1.71e-03	GO:0030217	T cell differentiation
1.32	1.76e-03	GO:0008104	protein localization
2.25	2.04e-03	GO:0050864	regulation of B cell activation
2.54	2.13e-03	GO:0019882	antigen processing and presentation
2.31	2.21e-03	GO:0002449	lymphocyte mediated immunity
2.01	2.27e-03	GO:0002237	response to molecule of bacterial origin
1.88	2.40e-03	GO:0051169	nuclear transport
1.23	2.41e-03	GO:0048513	organ development
2.74	2.46e-03	GO:0050830	defense response to Gram-positive bacterium
1.41	2.61e-03	GO:0046907	intracellular transport
2.67	2.82e-03	GO:0071222	cellular response to lipopolysaccharide
1.21	2.93e-03	GO:0071842	cellular component organization at cellular level
2.22	3.00e-03	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
1.36	3.62e-03	GO:0044093	positive regulation of molecular function
1.45	4.39e-03	GO:0006259	DNA metabolic process
1.46	4.53e-03	GO:0043069	negative regulation of programmed cell death
1.50	4.55e-03	GO:0006974	response to DNA damage stimulus
2.49	5.48e-03	GO:0045621	positive regulation of lymphocyte differentiation
2.40	5.68e-03	GO:0002263	cell activation involved in immune response
2.40	5.68e-03	GO:0002366	leukocyte activation involved in immune response
1.39	5.73e-03	GO:0006915	apoptosis
2.06	5.78e-03	GO:0032496	response to lipopolysaccharide
1.56	5.87e-03	GO:0051098	regulation of binding
1.46	5.96e-03	GO:0043066	negative regulation of apoptosis
1.46	5.96e-03	GO:0051726	regulation of cell cycle
1.64	5.97e-03	GO:0051101	regulation of DNA binding
1.45	6.55e-03	GO:0060548	negative regulation of cell death
1.43	6.85e-03	GO:0008284	positive regulation of cell proliferation
2.12	8.34e-03	GO:0071216	cellular response to biotic stimulus
1.30	8.50e-03	GO:0051641	cellular localization
1.53	8.61e-03	GO:0051130	positive regulation of cellular component organization
2.45	8.83e-03	GO:0071219	cellular response to molecule of bacterial origin
2.80	9.17e-03	GO:0048002	antigen processing and presentation of peptide antigen
1.61	9.54e-03	GO:0032446	protein modification by small protein conjugation
1.16	9.64e-03	GO:0007275	multicellular organismal development
1.57	9.66e-03	GO:0012502	induction of programmed cell death
1.27	1.00e-02	GO:0050790	regulation of catalytic activity
1.47	1.05e-02	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
2.08	1.07e-02	GO:0002819	regulation of adaptive immune response
1.66	1.08e-02	GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
1.87	1.14e-02	GO:0048872	homeostasis of number of cells
1.52	1.17e-02	GO:0007243	intracellular protein kinase cascade
1.52	1.17e-02	GO:0023014	signal transduction via phosphorylation event
2.10	1.17e-02	GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
1.46	1.20e-02	GO:0051247	positive regulation of protein metabolic process
1.66	1.25e-02	GO:0006954	inflammatory response
1.62	1.33e-02	GO:0016567	protein ubiquitination
2.50	1.35e-02	GO:0007249	I-kappaB kinase/NF-kappaB cascade
1.65	1.37e-02	GO:0090046	regulation of transcription regulator activity
1.47	1.38e-02	GO:0051338	regulation of transferase activity
3.53	1.46e-02	GO:0009620	response to fungus
1.56	1.55e-02	GO:0006917	induction of apoptosis
1.42	1.56e-02	GO:0048585	negative regulation of response to stimulus
3.67	1.88e-02	GO:0001562	response to protozoan
3.67	1.88e-02	GO:0042832	defense response to protozoan
1.87	1.93e-02	GO:0050670	regulation of lymphocyte proliferation
1.32	2.22e-02	GO:0007049	cell cycle
1.47	2.44e-02	GO:0010627	regulation of intracellular protein kinase cascade
1.85	2.49e-02	GO:0032944	regulation of mononuclear cell proliferation
1.54	2.54e-02	GO:0033043	regulation of organelle organization
1.28	2.61e-02	GO:0032879	regulation of localization
3.01	2.62e-02	GO:0019884	antigen processing and presentation of exogenous antigen
1.29	2.68e-02	GO:0044085	cellular component biogenesis
2.19	2.70e-02	GO:0010741	negative regulation of intracellular protein kinase cascade
1.45	2.72e-02	GO:0032270	positive regulation of cellular protein metabolic process
1.56	2.76e-02	GO:0007264	small GTPase mediated signal transduction
1.84	2.81e-02	GO:0042742	defense response to bacterium
1.21	3.03e-02	GO:0042221	response to chemical stimulus
1.62	3.30e-02	GO:0006897	endocytosis
1.62	3.30e-02	GO:0010324	membrane invagination
2.31	3.32e-02	GO:0033044	regulation of chromosome organization
1.54	3.34e-02	GO:0018193	peptidyl-amino acid modification
1.15	3.37e-02	GO:0051179	localization
2.35	3.41e-02	GO:0061008	hepaticobiliary system development
1.61	3.41e-02	GO:0043193	positive regulation of gene-specific transcription
2.40	3.45e-02	GO:0050851	antigen receptor-mediated signaling pathway
1.69	3.58e-02	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter
1.51	3.59e-02	GO:0070647	protein modification by small protein conjugation or removal
1.45	3.60e-02	GO:0043549	regulation of kinase activity
3.06	3.94e-02	GO:0046632	alpha-beta T cell differentiation
1.42	3.98e-02	GO:0071310	cellular response to organic substance
1.83	4.12e-02	GO:0070663	regulation of leukocyte proliferation
1.68	4.38e-02	GO:0034470	ncRNA processing

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
1.20	9.30e-47	GO:0005622	intracellular
1.37	5.99e-44	GO:0005634	nucleus
1.19	3.39e-43	GO:0044424	intracellular part
1.22	1.88e-33	GO:0043227	membrane-bounded organelle
1.22	2.48e-33	GO:0043231	intracellular membrane-bounded organelle
1.20	1.85e-32	GO:0043226	organelle
1.20	2.62e-32	GO:0043229	intracellular organelle
1.49	1.08e-21	GO:0044428	nuclear part
1.08	5.07e-18	GO:0005623	cell
1.08	5.07e-18	GO:0044464	cell part
1.50	8.62e-18	GO:0031981	nuclear lumen
1.56	4.01e-15	GO:0005654	nucleoplasm
1.40	1.14e-13	GO:0043233	organelle lumen
1.40	1.31e-13	GO:0070013	intracellular organelle lumen
1.14	2.53e-13	GO:0005737	cytoplasm
1.39	4.71e-13	GO:0031974	membrane-enclosed lumen
1.23	7.92e-13	GO:0044446	intracellular organelle part
1.22	3.99e-12	GO:0044422	organelle part
2.06	2.70e-10	GO:0009897	external side of plasma membrane
1.37	1.02e-09	GO:0005829	cytosol
1.23	1.99e-09	GO:0032991	macromolecular complex
1.52	3.67e-08	GO:0044451	nucleoplasm part
1.60	1.83e-07	GO:0030529	ribonucleoprotein complex
1.55	4.51e-06	GO:0009986	cell surface
1.20	2.88e-05	GO:0043234	protein complex
2.12	1.68e-04	GO:0000790	nuclear chromatin
1.94	1.81e-04	GO:0005681	spliceosomal complex
1.49	2.01e-04	GO:0005694	chromosome
1.20	2.47e-04	GO:0043228	non-membrane-bounded organelle
1.20	2.47e-04	GO:0043232	intracellular non-membrane-bounded organelle
1.48	8.09e-04	GO:0044427	chromosomal part
1.56	1.04e-03	GO:0005667	transcription factor complex
1.11	1.42e-03	GO:0044444	cytoplasmic part
1.48	2.46e-03	GO:0005730	nucleolus
1.70	2.74e-03	GO:0044454	nuclear chromosome part
1.63	4.72e-03	GO:0000785	chromatin
1.69	6.37e-03	GO:0031252	cell leading edge
1.61	1.09e-02	GO:0000228	nuclear chromosome

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
1.20	3.40e-45	GO:0005488	binding
1.30	9.73e-34	GO:0005515	protein binding
1.46	1.92e-29	GO:0003676	nucleic acid binding
1.48	1.55e-20	GO:0003677	DNA binding
1.60	2.51e-15	GO:0030528	transcription regulator activity
1.65	2.45e-12	GO:0043565	sequence-specific DNA binding
1.55	2.17e-10	GO:0001071	nucleic acid binding transcription factor activity
1.55	2.17e-10	GO:0003700	sequence-specific DNA binding transcription factor activity
1.52	2.19e-08	GO:0003723	RNA binding
1.75	1.92e-07	GO:0016564	transcription repressor activity
1.26	6.93e-07	GO:0000166	nucleotide binding
1.73	8.68e-07	GO:0008134	transcription factor binding
1.32	1.84e-06	GO:0008270	zinc ion binding
2.30	2.49e-06	GO:0019955	cytokine binding
1.27	1.72e-05	GO:0046914	transition metal ion binding
1.63	2.63e-05	GO:0016563	transcription activator activity
1.69	2.93e-05	GO:0046982	protein heterodimerization activity
1.81	4.14e-05	GO:0003682	chromatin binding
1.25	6.23e-05	GO:0035639	purine ribonucleoside triphosphate binding
1.37	6.40e-05	GO:0019899	enzyme binding
1.25	6.86e-05	GO:0017076	purine nucleotide binding
3.73	7.09e-05	GO:0001637	G-protein chemoattractant receptor activity
3.73	7.09e-05	GO:0004950	chemokine receptor activity
1.24	1.17e-04	GO:0032553	ribonucleotide binding
1.54	1.25e-04	GO:0060589	nucleoside-triphosphatase regulator activity
1.79	1.27e-04	GO:0019787	small conjugating protein ligase activity
1.40	1.28e-04	GO:0046983	protein dimerization activity
1.82	1.36e-04	GO:0004842	ubiquitin-protein ligase activity
1.24	1.49e-04	GO:0032555	purine ribonucleotide binding
3.47	1.60e-04	GO:0019956	chemokine binding
1.53	2.21e-04	GO:0030695	GTPase regulator activity
1.60	2.83e-04	GO:0008047	enzyme activator activity
1.71	9.20e-04	GO:0005096	GTPase activator activity
1.34	1.01e-03	GO:0030234	enzyme regulator activity
4.14	1.48e-03	GO:0016493	C-C chemokine receptor activity
1.57	1.61e-03	GO:0019900	kinase binding
1.24	1.84e-03	GO:0030554	adenyl nucleotide binding
1.62	1.90e-03	GO:0019901	protein kinase binding
1.24	2.33e-03	GO:0005524	ATP binding
1.65	2.91e-03	GO:0016881	acid-amino acid ligase activity
1.24	3.90e-03	GO:0032559	adenyl ribonucleotide binding
1.21	4.38e-03	GO:0016740	transferase activity
1.67	4.51e-03	GO:0043566	structure-specific DNA binding
3.84	5.61e-03	GO:0019957	C-C chemokine binding
1.11	6.19e-03	GO:0003824	catalytic activity
1.57	8.52e-03	GO:0005083	small GTPase regulator activity
1.63	8.73e-03	GO:0000975	regulatory region DNA binding
1.63	8.73e-03	GO:0001067	regulatory region nucleic acid binding
1.63	8.73e-03	GO:0044212	transcription regulatory region DNA binding
1.69	1.18e-02	GO:0005126	cytokine receptor binding
2.67	1.77e-02	GO:0035586	purinergic receptor activity
1.27	3.41e-02	GO:0016772	transferase activity, transferring phosphorus-containing groups
2.00	4.54e-02	GO:0005057	receptor signaling protein activity