Motif ID: SREBF1,2.p2

Z-value: 1.537


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
Srebf1 20787 sterol regulatory element binding transcription factor 1
Srebf2 20788 sterol regulatory element binding factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srebf2chr15_+_82000246-0.334.1e-06Click!
Srebf1chr11_-_600131410.222.5e-03Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_131135346 47.394 NM_013463
 Gla
galactosidase, alpha
chr8_+_77617514 44.046 NM_010442
 Hmox1
heme oxygenase (decycling) 1
chr8_+_77617542 40.594 Hmox1
heme oxygenase (decycling) 1
chr2_+_164659268 32.690 Ctsa
cathepsin A
chr10_-_18735154 32.067 NM_009397
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr8_+_120022149 32.045 NM_172285
 Plcg2
phospholipase C, gamma 2
chr10_+_122116066 31.152 Ppm1h
protein phosphatase 1H (PP2C domain containing)
chr10_+_122115755 31.068 NM_001110218
NM_176919
 Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr7_-_149573693 29.523 NM_009983
 Ctsd
cathepsin D
chr17_-_24300592 29.233 NM_172935
 Amdhd2
amidohydrolase domain containing 2
chr17_+_25270317 29.126 NM_011930
 Clcn7
chloride channel 7
chr10_+_120802099 28.769 NM_029364
 Gns
glucosamine (N-acetyl)-6-sulfatase
chr1_-_75138905 25.928 NM_026977
 1810031K17Rik
RIKEN cDNA 1810031K17 gene
chr7_-_133726668 25.357 NM_009907
 Cln3
ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
chr17_+_29629987 25.148 Pim1
proviral integration site 1
chr16_-_5204078 24.985 NM_013796
 Nagpa
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr11_+_102291635 24.831 NM_008175
 Grn
granulin
chr13_-_12742377 24.711 Gpr137b-ps
Gpr137b
G protein-coupled receptor 137B, pseudogene
G protein-coupled receptor 137B
chr16_-_5204069 24.570 Nagpa
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr2_-_25211822 24.456 NM_031843
 Dpp7
dipeptidylpeptidase 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 67 entries
Enrichment   P-value GO Accession GO Term
12.33 2.79e-02 GO:0021546 rhombomere development
7.30 1.83e-04 GO:0015988 energy coupled proton transport, against electrochemical gradient
7.30 1.83e-04 GO:0015991 ATP hydrolysis coupled proton transport
7.03 2.93e-04 GO:0007040 lysosome organization
6.91 9.95e-05 GO:0015682 ferric iron transport
6.91 9.95e-05 GO:0033572 transferrin transport
5.25 4.18e-04 GO:0007033 vacuole organization
4.80 5.84e-04 GO:0006826 iron ion transport
4.14 9.36e-06 GO:0000041 transition metal ion transport
3.73 9.09e-03 GO:0048704 embryonic skeletal system morphogenesis
3.42 4.81e-03 GO:0048706 embryonic skeletal system development
2.90 2.06e-03 GO:0048705 skeletal system morphogenesis
2.88 2.21e-04 GO:0009952 anterior/posterior pattern formation
2.36 2.45e-03 GO:0001501 skeletal system development
2.34 5.51e-03 GO:0003002 regionalization
2.24 4.51e-04 GO:0007389 pattern specification process
2.17 3.18e-02 GO:0048568 embryonic organ development
2.14 1.09e-02 GO:0006886 intracellular protein transport
2.06 1.98e-05 GO:0046907 intracellular transport
2.06 2.77e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
11.51 1.70e-05 GO:0016471 vacuolar proton-transporting V-type ATPase complex
9.99 3.95e-07 GO:0033176 proton-transporting V-type ATPase complex
5.60 2.21e-04 GO:0016469 proton-transporting two-sector ATPase complex
4.82 2.04e-06 GO:0005774 vacuolar membrane
4.73 1.19e-06 GO:0044437 vacuolar part
4.30 1.66e-23 GO:0005773 vacuole
4.30 1.39e-19 GO:0000323 lytic vacuole
4.30 1.39e-19 GO:0005764 lysosome
2.54 2.93e-09 GO:0005768 endosome
1.82 6.08e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.76 1.36e-02 GO:0031988 membrane-bounded vesicle
1.74 1.37e-03 GO:0031410 cytoplasmic vesicle
1.73 9.05e-04 GO:0031982 vesicle
1.58 6.47e-03 GO:0005794 Golgi apparatus
1.52 2.52e-02 GO:0005654 nucleoplasm
1.38 5.07e-23 GO:0043227 membrane-bounded organelle
1.37 9.72e-23 GO:0043231 intracellular membrane-bounded organelle
1.35 1.87e-10 GO:0044444 cytoplasmic part
1.32 1.86e-20 GO:0043226 organelle
1.32 4.61e-20 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
8.63 2.88e-03 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism
3.62 2.52e-02 GO:0042625 ATPase activity, coupled to transmembrane movement of ions
2.47 5.07e-03 GO:0022890 inorganic cation transmembrane transporter activity
2.03 2.41e-02 GO:0022804 active transmembrane transporter activity
2.02 3.48e-06 GO:0043565 sequence-specific DNA binding
2.01 3.48e-07 GO:0001071 nucleic acid binding transcription factor activity
2.01 3.48e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.81 1.20e-05 GO:0030528 transcription regulator activity
1.56 8.62e-06 GO:0003677 DNA binding
1.48 1.10e-06 GO:0003676 nucleic acid binding
1.27 9.55e-06 GO:0005515 protein binding
1.20 1.98e-02 GO:0003824 catalytic activity
1.19 6.61e-09 GO:0005488 binding