Motif ID: SRY.p2

Z-value: 0.923


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
Sry 21674 sex determining region of Chr Y

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SrychrY_-_19195670.073.7e-01Click!


Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_129776837 23.427 Prkcb
protein kinase C, beta
chr9_+_120058842 23.358 NM_001039364
NM_001039365
NM_008614
Mobp


myelin-associated oligodendrocytic basic protein


chr17_-_51878720 15.200 Satb1
special AT-rich sequence binding protein 1
chr1_-_140071630 13.495 Ptprc
protein tyrosine phosphatase, receptor type, C
chr6_+_30400873 12.401


chr12_-_32893074 11.098 NM_001146201
NM_020272
NM_001146200
Pik3cg


phosphoinositide-3-kinase, catalytic, gamma polypeptide


chr14_-_122314994 10.911 NM_182806
Gpr18
G protein-coupled receptor 18
chr9_-_52484889 7.711 AI593442
expressed sequence AI593442
chr17_-_51951378 7.711 NM_001163630
Satb1
special AT-rich sequence binding protein 1
chrX_+_13209894 7.098 NM_011823
Gpr34
G protein-coupled receptor 34
chr3_-_20142068 7.042 NM_007753
Cpa3
carboxypeptidase A3, mast cell
chr16_-_46120221 6.751 NM_032465
Cd96
CD96 antigen
chr4_+_102243132 6.640 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_+_112124767 6.506 NM_133648
Slc12a6
solute carrier family 12, member 6
chr18_-_23197156 6.393 NM_001161483
Nol4
nucleolar protein 4
chr3_+_52072251 6.346 NM_019739
Foxo1
forkhead box O1
chr2_-_57905140 6.168 NM_029972
Ermn
ermin, ERM-like protein
chr3_-_58905678 6.122 NM_173398
Gpr171
G protein-coupled receptor 171
chr15_+_91958558 6.055 NM_007727
Cntn1
contactin 1
chr8_+_56040553 6.048 Gpm6a
glycoprotein m6a
chr1_-_80661844 5.800 Dock10
dedicator of cytokinesis 10
chr11_-_118025722 5.647 Cyth1
cytohesin 1
chr2_-_7002287 5.578 Celf2
CUGBP, Elav-like family member 2
chr1_-_140071818 5.518 NM_001111316
NM_011210
Ptprc

protein tyrosine phosphatase, receptor type, C

chr16_+_33500899 5.517 Zfp148
zinc finger protein 148
chr1_-_42749940 5.505 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr12_-_4344470 5.351 Ncoa1
nuclear receptor coactivator 1
chr7_+_97535490 5.239 NM_001040087
NM_001040088
Sytl2

synaptotagmin-like 2

chr6_+_123212124 5.223 NM_001163161
NM_010819
Clec4d

C-type lectin domain family 4, member d

chr2_+_143371807 5.186 NM_008792
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr8_+_68910191 4.803 NM_001166375
March1
membrane-associated ring finger (C3HC4) 1
chr14_-_49282546 4.795 NM_144841
Otx2
orthodenticle homolog 2 (Drosophila)
chr4_-_120642197 4.792 Smap2
stromal membrane-associated GTPase-activating protein 2
chr11_-_79343891 4.706 Evi2a
ecotropic viral integration site 2a
chr18_-_43219062 4.695 NM_028392
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr10_+_67000613 4.636 NM_010118
Egr2
early growth response 2
chr4_+_102262447 4.622 NM_001177981
Pde4b
phosphodiesterase 4B, cAMP specific
chr11_-_97372344 4.616 Srcin1
SRC kinase signaling inhibitor 1
chr9_-_71011053 4.579 NM_022026
Aqp9
aquaporin 9
chr19_+_54003803 4.484 Pdcd4
programmed cell death 4
chr3_+_52072302 4.442 Foxo1
forkhead box O1
chr17_+_45692647 4.402 NM_008690
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr11_-_103733519 4.360 Nsf
N-ethylmaleimide sensitive fusion protein
chr16_-_36666078 4.319 NM_019388
Cd86
CD86 antigen
chr4_-_142718290 4.317 Prdm2
PR domain containing 2, with ZNF domain
chr1_+_9591550 4.313 3110035E14Rik
RIKEN cDNA 3110035E14 gene
chr10_+_98486068 4.293 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr3_+_95330700 4.258 NM_021281
Ctss
cathepsin S
chr9_+_55937776 4.161 NM_011193
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr4_-_126114651 4.141 Eif2c1
eukaryotic translation initiation factor 2C, 1
chr6_-_141804691 4.123 NM_030687
Slco1a4
solute carrier organic anion transporter family, member 1a4
chr8_+_56040445 4.121 Gpm6a
glycoprotein m6a
chr15_-_66392539 4.034 NM_172514
Tmem71
transmembrane protein 71
chr3_+_60432922 4.028 Mbnl1
muscleblind-like 1 (Drosophila)
chr14_-_56563373 4.018 Cma1
chymase 1, mast cell
chr11_+_93905443 4.003 Spag9
sperm associated antigen 9
chr9_+_44448105 3.990 Ddx6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr6_-_3349470 3.955 NM_010156
Samd9l
sterile alpha motif domain containing 9-like
chr14_+_26484518 3.942 Gm10397
predicted gene 10397
chr11_+_93905557 3.935 Spag9
sperm associated antigen 9
chrX_+_160528118 3.917 NM_020626
Tmem27
transmembrane protein 27
chr3_+_17695743 3.842 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr2_-_170232008 3.809 Bcas1
breast carcinoma amplified sequence 1
chr13_+_54203236 3.762 Sfxn1
sideroflexin 1
chr9_-_91255831 3.744 Zic1
zinc finger protein of the cerebellum 1
chr6_+_87040212 3.728 Gfpt1
glutamine fructose-6-phosphate transaminase 1
chr1_-_146024404 3.657 NM_153171
Rgs13
regulator of G-protein signaling 13
chr11_-_79337251 3.647 NM_001077496
Evi2b
ecotropic viral integration site 2b
chr9_-_32348863 3.646 NM_008026
Fli1
Friend leukemia integration 1
chr10_-_117252126 3.574


chr9_-_44613544 3.568


chr5_+_89012596 3.560 NM_027530
Rufy3
RUN and FYVE domain containing 3
chr15_+_35860580 3.554 Vps13b
vacuolar protein sorting 13B (yeast)
chr5_+_27231234 3.526 NM_001198886
Dpp6
dipeptidylpeptidase 6
chr11_+_58020859 3.473 Igtp
interferon gamma induced GTPase
chr10_+_4978808 3.461 Syne1
synaptic nuclear envelope 1
chr12_-_73337534 3.446 Rtn1
reticulon 1
chr11_-_94154354 3.444 Luc7l3
LUC7-like 3 (S. cerevisiae)
chr16_-_4941654 3.438 Anks3
ankyrin repeat and sterile alpha motif domain containing 3
chr11_+_87574041 3.427 NM_172449
Bzrap1
benzodiazepine receptor associated protein 1
chr7_-_111613624 3.399 NM_009099
Trim30a
tripartite motif-containing 30A
chr18_-_77870871 3.391 2310007O11Rik
RIKEN cDNA 2310007O11 gene
chr7_+_53693190 3.385 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr7_+_97535516 3.370 Sytl2
synaptotagmin-like 2
chr5_+_89012547 3.356 Rufy3
RUN and FYVE domain containing 3
chr6_-_13789847 3.352 NM_145066
Gpr85
G protein-coupled receptor 85
chr7_-_82453166 3.351 Sv2b
synaptic vesicle glycoprotein 2 b
chr5_-_123183537 3.345 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr10_+_59765201 3.334


chr15_+_16707855 3.313 NM_009869
Cdh9
cadherin 9
chr2_-_129196855 3.256 NM_008361
Il1b
interleukin 1 beta
chr4_+_102242664 3.215 NM_001177980
Pde4b
phosphodiesterase 4B, cAMP specific
chr8_-_74150754 3.212 Unc13a
unc-13 homolog A (C. elegans)
chr10_+_126603057 3.206 B4galnt1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr7_+_97357406 3.205 Picalm
phosphatidylinositol binding clathrin assembly protein
chr9_+_109905895 3.173


chr4_-_70195870 3.154 Megf9
multiple EGF-like-domains 9
chr11_+_117623703 3.129 Tnrc6c
trinucleotide repeat containing 6C
chr3_+_87975676 3.122


chr11_+_31900378 3.113 NM_008741
Nsg2
neuron specific gene family member 2
chr4_-_70195952 3.108 NM_172694
Megf9
multiple EGF-like-domains 9
chr3_+_133899454 3.104 Cxxc4
CXXC finger 4
chrX_-_54591905 3.060 NM_152801
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr3_-_101091814 3.049 NM_013486
Cd2
CD2 antigen
chr13_+_118009379 3.035 NM_010330
Emb
embigin
chr10_+_4978047 3.034 Syne1
synaptic nuclear envelope 1
chr6_-_132264751 2.999 NM_001024705
Prpmp5
proline-rich protein MP5
chr16_+_52031704 2.998 Cblb
Casitas B-lineage lymphoma b
chr17_-_37712365 2.997 NM_146289
Olfr113
olfactory receptor 113
chr10_+_20760625 2.968 NM_001177776
Ahi1
Abelson helper integration site 1
chr1_+_160292665 2.966 Astn1
astrotactin 1
chr11_-_16908631 2.956 NM_019549
Plek
pleckstrin
chr2_-_7002344 2.941 NM_001110229
NM_001110230
NM_001160292
Celf2


CUGBP, Elav-like family member 2


chr11_-_68635236 2.934 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr10_-_52058305 2.858 Gopc
golgi associated PDZ and coiled-coil motif containing
chr1_-_173537404 2.842 NM_008534
Ly9
lymphocyte antigen 9
chr9_+_7347373 2.829 NM_008605
Mmp12
matrix metallopeptidase 12
chr16_-_11137100 2.824 Zc3h7a
zinc finger CCCH type containing 7 A
chr14_-_45839064 2.814 NM_172597
Txndc16
thioredoxin domain containing 16
chrX_-_161764912 2.802 NM_183427
Glra2
glycine receptor, alpha 2 subunit
chr2_-_91773029 2.799


chr4_+_126800830 2.794 Zmym6
zinc finger, MYM-type 6
chr19_-_4333914 2.790


chr1_+_9591492 2.772 3110035E14Rik
RIKEN cDNA 3110035E14 gene
chr1_+_66368571 2.769 Mtap2
microtubule-associated protein 2
chr14_+_61351770 2.752 Spata13
spermatogenesis associated 13
chr19_-_41151561 2.735 NM_153520
Opalin
oligodendrocytic myelin paranodal and inner loop protein
chr18_-_39572137 2.733 Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr13_+_59234737 2.724 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr6_+_121195885 2.701 NM_011909
Usp18
ubiquitin specific peptidase 18
chr1_-_79436564 2.699 NM_009129
Scg2
secretogranin II
chr5_+_19413335 2.694 NM_001170745
NM_015823
Magi2

membrane associated guanylate kinase, WW and PDZ domain containing 2

chr15_-_77787128 2.688 NM_001017983
NM_001168260
Foxred2

FAD-dependent oxidoreductase domain containing 2

chr1_+_160292470 2.687 NM_007495
Astn1
astrotactin 1
chr14_+_79915429 2.672 Elf1
E74-like factor 1
chr6_+_143156520 2.662 Etnk1
ethanolamine kinase 1
chr4_+_48197852 2.659 Stx17
syntaxin 17
chr2_-_148263617 2.636 Cd93
CD93 antigen
chr8_+_119983566 2.633 4933407C03Rik
RIKEN cDNA 4933407C03 gene
chr2_+_158492468 2.628 NM_153089
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr12_+_105452740 2.618 NM_009251
NM_001168294
NM_001168295
NM_001033335
Serpina3g
Serpina3f


Serpina3h
serine (or cysteine) peptidase inhibitor, clade A, member 3G
serine (or cysteine) peptidase inhibitor, clade A, member 3F


serine (or cysteine) peptidase inhibitor, clade A, member 3H
chr11_-_79344055 2.583 NM_001033711
NM_010161
NM_146023
Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chr2_+_102498839 2.570 NM_001077514
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr13_-_93258004 2.561 Zfyve16
zinc finger, FYVE domain containing 16
chr16_-_22811458 2.552 NM_009967
Crygs
crystallin, gamma S
chr14_+_37881214 2.545 NM_173418
Lrit2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr16_+_43619057 2.541 Zbtb20
zinc finger and BTB domain containing 20
chr6_+_141472906 2.539 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chrX_-_110299092 2.539 NM_018818
Chm
choroidermia
chr10_-_80693488 2.527 NM_178662
Atcay
ataxia, cerebellar, Cayman type homolog (human)
chr13_+_24904944 2.524 BC005537
cDNA sequence BC005537
chr8_+_119984482 2.522 4933407C03Rik
RIKEN cDNA 4933407C03 gene
chrX_+_162782484 2.509 NM_001177955
NM_001177956
NM_001177957
NM_001177958
NM_001177959
NM_001177960
Gpm6b





glycoprotein m6b





chr4_+_134483092 2.500


chr12_+_105474449 2.494 Serpina3g
serine (or cysteine) peptidase inhibitor, clade A, member 3G
chr12_-_73337707 2.492 NM_001007596
Rtn1
reticulon 1
chr9_+_69855789 2.488 Bnip2
BCL2/adenovirus E1B interacting protein 2
chr16_-_34263047 2.487 Kalrn
kalirin, RhoGEF kinase
chr11_-_98190774 2.483 NM_010895
Neurod2
neurogenic differentiation 2
chr1_-_42751652 2.480 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr11_+_93905501 2.479 NM_001025428
NM_001025429
NM_001025430
Spag9


sperm associated antigen 9


chr18_-_43847367 2.475 NM_001163637
Jakmip2
janus kinase and microtubule interacting protein 2
chr2_+_92025639 2.445 NM_001109691
Phf21a
PHD finger protein 21A
chr8_+_90812964 2.443 NM_001037723
Adcy7
adenylate cyclase 7
chr9_+_103014279 2.442 Rab6b
RAB6B, member RAS oncogene family
chr18_+_37120093 2.429 NM_009959
Pcdha5
protocadherin alpha 5
chr6_+_30758582 2.420 Copg2as2
coatomer protein complex, subunit gamma 2, antisense 2
chr15_-_77787081 2.413 Foxred2
FAD-dependent oxidoreductase domain containing 2
chr19_+_53977901 2.405 Pdcd4
programmed cell death 4
chr10_+_5277477 2.403 NM_022027
Syne1
synaptic nuclear envelope 1
chr14_-_37911383 2.398 NM_130878
Cdhr1
cadherin-related family member 1
chr3_-_27795287 2.363 NM_001164437
Tmem212
transmembrane protein 212
chr3_-_66100663 2.350 NM_145820
Veph1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr6_+_54222814 2.340 NM_023543
Chn2
chimerin (chimaerin) 2
chr17_+_4995073 2.338 NM_001085355
Arid1b
AT rich interactive domain 1B (SWI-like)
chr1_-_54983132 2.319 Ankrd44
ankyrin repeat domain 44
chr16_-_52268571 2.310 Alcam
activated leukocyte cell adhesion molecule
chr19_+_11518042 2.304 NM_021718
Ms4a4b
membrane-spanning 4-domains, subfamily A, member 4B
chr6_-_68967061 2.295


chr5_+_88431549 2.288 NM_011422
Smr3a
submaxillary gland androgen regulated protein 3A
chr10_-_118293979 2.287 Dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr5_+_123093892 2.280 NM_001038839
NM_001038845
NM_001038887
NM_011027
P2rx7



purinergic receptor P2X, ligand-gated ion channel, 7



chr18_+_37152024 2.278 NM_201243
Pcdha8
protocadherin alpha 8
chr14_-_45838944 2.275 Txndc16
thioredoxin domain containing 16
chr8_+_68142423 2.271 NM_175188
March1
membrane-associated ring finger (C3HC4) 1
chr2_+_136539143 2.268 NM_011428
Snap25
synaptosomal-associated protein 25
chr6_+_120314442 2.267 Kdm5a
lysine (K)-specific demethylase 5A
chr19_+_12535536 2.265 Mpeg1
macrophage expressed gene 1
chr2_-_147011990 2.257 NM_001077632
NM_010919
Nkx2-2

NK2 transcription factor related, locus 2 (Drosophila)

chr16_-_34263272 2.253 Kalrn
kalirin, RhoGEF kinase
chr6_+_120314116 2.250 NM_145997
Kdm5a
lysine (K)-specific demethylase 5A
chr18_+_37560490 2.248 NM_053134
Pcdhb9
protocadherin beta 9
chr3_+_127494295 2.225 Tifa
TRAF-interacting protein with forkhead-associated domain
chr12_+_3365295 2.222 Kif3c
kinesin family member 3C
chr2_-_62484208 2.222 Ifih1
interferon induced with helicase C domain 1
chr6_+_41488583 2.222


chr1_-_42724504 2.217 2610017I09Rik
RIKEN cDNA 2610017I09 gene
chr10_+_96079634 2.214 NM_007569
Btg1
B-cell translocation gene 1, anti-proliferative
chr17_+_6877959 2.210 NM_031395
Sytl3
synaptotagmin-like 3
chr12_+_25741653 2.206 Kidins220
kinase D-interacting substrate 220

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.23 5.04e-06 GO:0019222 regulation of metabolic process
1.25 7.62e-06 GO:0031323 regulation of cellular metabolic process
1.25 1.52e-05 GO:0060255 regulation of macromolecule metabolic process
1.28 2.68e-05 GO:0048518 positive regulation of biological process
1.24 3.44e-05 GO:0080090 regulation of primary metabolic process
1.29 7.86e-05 GO:0048522 positive regulation of cellular process
1.44 1.59e-04 GO:0007399 nervous system development
1.30 1.61e-04 GO:0006355 regulation of transcription, DNA-dependent
1.27 2.14e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.26 3.03e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.26 3.23e-04 GO:0009889 regulation of biosynthetic process
1.28 3.46e-04 GO:0051252 regulation of RNA metabolic process
1.26 3.69e-04 GO:0031326 regulation of cellular biosynthetic process
1.28 3.88e-04 GO:0048731 system development
1.26 6.24e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.59 8.47e-04 GO:0002682 regulation of immune system process
1.25 9.36e-04 GO:0048856 anatomical structure development
1.26 9.80e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.59 1.45e-03 GO:0009605 response to external stimulus
1.33 2.42e-03 GO:0048583 regulation of response to stimulus
1.22 2.86e-03 GO:0032502 developmental process
2.20 5.05e-03 GO:0042110 T cell activation
1.22 5.39e-03 GO:0007275 multicellular organismal development
1.23 6.74e-03 GO:0010468 regulation of gene expression
1.42 7.16e-03 GO:0002376 immune system process
1.82 8.18e-03 GO:0045321 leukocyte activation
1.89 1.58e-02 GO:0046649 lymphocyte activation
1.26 1.59e-02 GO:0048523 negative regulation of cellular process
2.65 2.18e-02 GO:0016202 regulation of striated muscle tissue development
1.65 2.33e-02 GO:0007610 behavior
1.44 2.57e-02 GO:0048699 generation of neurons
1.72 2.58e-02 GO:0001775 cell activation
3.26 2.78e-02 GO:0051153 regulation of striated muscle cell differentiation
1.28 2.78e-02 GO:0006351 transcription, DNA-dependent
1.28 3.19e-02 GO:0032774 RNA biosynthetic process
2.58 3.73e-02 GO:0048634 regulation of muscle organ development
2.74 4.88e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.18 2.34e-03 GO:0005886 plasma membrane
1.15 2.48e-03 GO:0005634 nucleus
1.18 3.54e-03 GO:0071944 cell periphery
1.35 5.15e-03 GO:0042995 cell projection
1.08 5.46e-03 GO:0005622 intracellular
1.27 2.80e-02 GO:0005856 cytoskeleton
1.68 3.05e-02 GO:0030424 axon
1.07 4.84e-02 GO:0044424 intracellular part
1.91 5.00e-02 GO:0030136 clathrin-coated vesicle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.17 2.34e-05 GO:0005515 protein binding
1.09 8.68e-05 GO:0005488 binding
1.38 9.55e-05 GO:0008270 zinc ion binding
1.32 5.83e-04 GO:0046914 transition metal ion binding
1.19 7.20e-03 GO:0046872 metal ion binding
1.19 7.43e-03 GO:0043169 cation binding
1.18 1.11e-02 GO:0043167 ion binding
1.39 1.12e-02 GO:0030528 transcription regulator activity
1.40 1.24e-02 GO:0030234 enzyme regulator activity
1.42 1.28e-02 GO:0001071 nucleic acid binding transcription factor activity
1.42 1.28e-02 GO:0003700 sequence-specific DNA binding transcription factor activity