Motif ID: STAT1,3.p3

Z-value: 1.357


Transcription factors associated with STAT1,3.p3:

Gene SymbolEntrez IDGene Name
Stat1 20846 signal transducer and activator of transcription 1
Stat3 20848 signal transducer and activator of transcription 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat1chr1_+_521762810.701.3e-28Click!
Stat3chr11_-_1007491310.444.4e-10Click!


Activity profile for motif STAT1,3.p3.

activity profile for motif STAT1,3.p3


Sorted Z-values histogram for motif STAT1,3.p3

Sorted Z-values for motif STAT1,3.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT1,3.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66663390 58.372 NM_001029841
Sla
src-like adaptor
chr9_+_20820403 41.086 NM_010493
Icam1
intercellular adhesion molecule 1
chr12_+_105452740 32.866 NM_009251
NM_001168294
NM_001168295
NM_001033335
Serpina3g
Serpina3f


Serpina3h
serine (or cysteine) peptidase inhibitor, clade A, member 3G
serine (or cysteine) peptidase inhibitor, clade A, member 3F


serine (or cysteine) peptidase inhibitor, clade A, member 3H
chr11_+_58028478 29.067 NM_019440
Irgm2
immunity-related GTPase family M member 2
chr16_-_35871459 28.586 NM_001039530
Parp14
poly (ADP-ribose) polymerase family, member 14
chr7_-_113102453 27.675 NM_001039160
NM_029000
Gvin1

GTPase, very large interferon inducible 1

chr7_-_113358823 27.675 NM_001039160
NM_029000
Gvin1

GTPase, very large interferon inducible 1

chr11_+_58028487 26.851 Irgm2
immunity-related GTPase family M member 2
chr2_+_103798150 25.100 NM_001142337
Lmo2
LIM domain only 2
chr11_+_48900507 22.442 NM_008330
Ifi47
Olfr56
interferon gamma inducible protein 47
olfactory receptor 56
chr11_-_117830455 22.082 Socs3
suppressor of cytokine signaling 3
chr8_+_123260247 21.974 NM_008320
Irf8
interferon regulatory factor 8
chr1_+_172949049 18.719 NM_144559
Fcgr4
Fc receptor, IgG, low affinity IV
chr11_+_58013057 18.597 NM_018738
Igtp
interferon gamma induced GTPase
chr17_-_32557807 16.459 Pglyrp2
peptidoglycan recognition protein 2
chr2_-_163575826 16.428 NM_007398
Ada
adenosine deaminase
chr11_-_98859189 16.358 Top2a
topoisomerase (DNA) II alpha
chr1_+_172949069 16.200 Fcgr4
Fc receptor, IgG, low affinity IV
chr7_+_50692442 13.900 NM_024253
Nkg7
natural killer cell group 7 sequence
chr6_+_48634576 11.115 NM_174990
NM_175048
Gimap4

GTPase, IMAP family member 4

chr11_-_82684245 10.244 NM_001164570
Rffl
ring finger and FYVE like domain containing protein
chr11_-_82684643 10.121 Rffl
ring finger and FYVE like domain containing protein
chr11_-_48877704 9.965 NM_001145164
Tgtp2
T-cell specific GTPase 2
chr6_+_70676428 9.889


chr18_-_84855007 9.750 NM_023149
Cndp2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr9_+_108242511 9.515


chr7_+_31206749 9.416 Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr17_+_34974004 9.341 Dom3z
DOM-3 homolog Z (C. elegans)
chr15_-_82160509 9.221 Naga
N-acetyl galactosaminidase, alpha
chr7_+_29222465 9.088 NM_022024
Gmfg
glia maturation factor, gamma
chr17_+_34973963 9.031 NM_001163770
NM_033613
Dom3z

DOM-3 homolog Z (C. elegans)

chr13_+_67295437 8.946 NM_001048204
Zfp455
zinc finger protein 455
chr9_-_123883223 8.857 Ccr1
chemokine (C-C motif) receptor 1
chr4_-_136448748 8.671 NM_007574
C1qc
complement component 1, q subcomponent, C chain
chr11_-_82684653 8.353 NM_001007465
NM_001164569
NM_001164571
Rffl


ring finger and FYVE like domain containing protein


chr6_+_129347314 8.264 NM_019985
Clec1b
C-type lectin domain family 1, member b
chr11_-_117830554 7.945 NM_007707
Socs3
suppressor of cytokine signaling 3
chr12_+_85291629 7.806 2410016O06Rik
RIKEN cDNA 2410016O06 gene
chr6_+_48634586 7.757 Gimap4
GTPase, IMAP family member 4
chr17_-_34973781 7.687 NM_019442
Stk19
serine/threonine kinase 19
chr11_-_48805585 7.601 NM_001145164
NM_011579
Tgtp2
Tgtp1
Gm12185
T-cell specific GTPase 2
T-cell specific GTPase 1
predicted gene 12185
chr17_-_34999068 7.530 Cfb
complement factor B
chr11_-_102226419 7.265 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr12_+_85291605 7.231 2410016O06Rik
RIKEN cDNA 2410016O06 gene
chr1_+_173697246 7.090 NM_013730
Slamf1
signaling lymphocytic activation molecule family member 1
chr4_+_115500670 6.852 NM_175308
Mobkl2c
MOB1, Mps One Binder kinase activator-like 2C (yeast)
chr15_-_63829523 6.693 Fam49b
family with sequence similarity 49, member B
chr7_+_127987068 6.611 Eef2k
eukaryotic elongation factor-2 kinase
chr4_+_118100682 6.574 NM_001039175
NM_019422
Elovl1

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1

chrX_-_70327816 6.567 NM_001081642
Xlr4a
X-linked lymphocyte-regulated 4A
chr5_-_73127743 6.490 NM_013698
Txk
TXK tyrosine kinase
chr16_+_91373153 6.382 Ifnar2
interferon (alpha and beta) receptor 2
chr11_-_102331042 6.264 NM_010575
Itga2b
integrin alpha 2b
chrX_-_9014351 5.997 Cybb
cytochrome b-245, beta polypeptide
chr7_-_52391419 5.533 Flt3l
FMS-like tyrosine kinase 3 ligand
chr1_-_158585297 5.365 Tor3a
torsin family 3, member A
chr19_+_11986887 5.010 NM_172635
Patl1
protein associated with topoisomerase II homolog 1 (yeast)
chr11_-_48877544 4.948 Tgtp2
Tgtp1
T-cell specific GTPase 2
T-cell specific GTPase 1
chr3_+_109376824 4.848 NM_146139
Vav3
vav 3 oncogene
chr7_+_148048854 4.742


chr6_-_122806020 4.703 C3ar1
complement component 3a receptor 1
chr8_+_47825072 4.653 Irf2
interferon regulatory factor 2
chr2_-_7317824 4.576 NM_001110231
Celf2
CUGBP, Elav-like family member 2
chr17_+_35403130 4.392 H2-D1
histocompatibility 2, D region locus 1
chr2_-_120966376 4.365 NM_177846
Lcmt2
leucine carboxyl methyltransferase 2
chr16_+_91373008 4.356 NM_001110498
NM_010509
Ifnar2

interferon (alpha and beta) receptor 2

chr4_+_63221260 4.311 NM_144905
6330416G13Rik
RIKEN cDNA 6330416G13 gene
chr11_+_5700192 4.243 Dbnl
drebrin-like
chr12_+_85291557 4.228 NM_023633
2410016O06Rik
RIKEN cDNA 2410016O06 gene
chr7_-_55237665 4.199 NM_153524
Mrgpra4
MAS-related GPR, member A4
chr4_-_106850812 4.190 NM_025617
2210012G02Rik
RIKEN cDNA 2210012G02 gene
chr18_-_84849981 4.169 Cndp2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr11_-_102226475 4.023 NM_011403
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr16_-_17722915 3.965 NM_001040683
NM_033609
Med15

mediator complex subunit 15

chr11_-_54776398 3.862 NM_021327
Tnip1
TNFAIP3 interacting protein 1
chr6_-_122806122 3.845 NM_009779
C3ar1
complement component 3a receptor 1
chr8_-_113605607 3.734 NM_181549
Clec18a
C-type lectin domain family 18, member A
chr13_-_67601323 3.719 NM_001007575
Zfp58
zinc finger protein 58
chr11_+_70783966 3.663 Rpain
RPA interacting protein
chr8_-_125135240 3.524 NM_001193645
NM_016722
Galns

galactosamine (N-acetyl)-6-sulfate sulfatase

chr10_-_126725826 3.414 NM_033072
Mbd6
methyl-CpG binding domain protein 6
chr12_+_11272691 3.366 NM_025695
Smc6
structural maintenance of chromosomes 6
chr7_-_97103461 3.292


chr1_+_40572206 3.189 NM_010553
Il18rap
interleukin 18 receptor accessory protein
chr7_-_111161213 3.091 NM_147084
Olfr639
olfactory receptor 639
chr1_+_133535033 2.894 Ctse
cathepsin E
chrX_+_6644644 2.885 NM_009651
Akap4
A kinase (PRKA) anchor protein 4
chr13_-_67856070 2.860 NM_001001130
Zfp85-rs1
zinc finger protein 85, related sequence 1
chr17_-_79281817 2.859 NM_011163
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr7_-_31397744 2.835 Upk1a
uroplakin 1A
chr14_-_104921839 2.831 NM_026047
Rnf219
ring finger protein 219
chr9_-_123883398 2.745 NM_009912
Ccr1
chemokine (C-C motif) receptor 1
chr11_-_106646226 2.737 Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr11_+_81849074 2.728 NM_011333
Ccl2
chemokine (C-C motif) ligand 2
chr19_-_4269161 2.699 NM_198113
Ssh3
slingshot homolog 3 (Drosophila)
chr10_+_79342408 2.476 NM_011178
Prtn3
proteinase 3
chr3_-_40659202 2.435 NM_001129886
Gm10731
predicted gene 10731
chr7_-_52391649 2.416 Flt3l
FMS-like tyrosine kinase 3 ligand
chr12_-_105228099 2.408 NM_199314
NM_001166350
Serpina11

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11

chr16_-_30310864 2.401 NM_008148
Gp5
glycoprotein 5 (platelet)
chrX_-_137491205 2.397 NM_001164177
NM_016883
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr9_+_107199169 2.351 Cish
cytokine inducible SH2-containing protein
chr9_-_100407241 2.336 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr9_+_72286335 2.326 NM_008613
Mns1
meiosis-specific nuclear structural protein 1
chr2_-_90420529 2.302 Ptprj
protein tyrosine phosphatase, receptor type, J
chr11_+_81915343 2.294 NM_011331
Ccl12
chemokine (C-C motif) ligand 12
chr2_+_164881126 2.286 NM_011611
NM_170702
NM_170703
NM_170704
Cd40



CD40 antigen



chr7_+_133924996 2.280 NM_011538
Tbx6
T-box 6
chr1_-_122161827 2.260 NM_133186
Steap3
STEAP family member 3
chr1_+_40522814 2.227 NM_008365
Il18r1
interleukin 18 receptor 1
chr4_+_108520389 2.170 NM_029571
Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr19_-_4269096 2.111 Ssh3
slingshot homolog 3 (Drosophila)
chr5_-_135391315 2.044 Cldn13
claudin 13
chr7_-_138473006 1.998 NM_027037
1700007K09Rik
RIKEN cDNA 1700007K09 gene
chr19_-_12841737 1.998 Zfp91
zinc finger protein 91
chr11_-_48740660 1.832 NM_001045540
Gm12185
predicted gene 12185
chr18_+_42671130 1.816 NM_001039474
Tcerg1
transcription elongation regulator 1 (CA150)
chrX_-_90877453 1.806 NM_008892
Pola1
polymerase (DNA directed), alpha 1
chr8_-_11478623 1.766 Rab20
RAB20, member RAS oncogene family
chr6_+_87728129 1.750 NM_018762
Gp9
glycoprotein 9 (platelet)
chr7_+_30601080 1.654 NM_001145880
NM_146185
Zfp790

zinc finger protein 790

chr1_+_40496493 1.640 NM_010743
Il1rl1
interleukin 1 receptor-like 1
chr3_+_95462640 1.633 NM_008562
Mcl1
myeloid cell leukemia sequence 1
chr13_+_67914748 1.614 NM_198322
Zfp273
zinc finger protein 273
chr5_+_15124916 1.569 NM_025759
Speer4d
spermatogenesis associated glutamate (E)-rich protein 4d
chr3_-_89568525 1.544 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr8_-_37676914 1.534 Dlc1
deleted in liver cancer 1
chr9_-_44042043 1.531 NM_007619
Cbl
Casitas B-lineage lymphoma
chr7_-_4397194 1.529 NM_175372
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr5_-_136048841 1.503 NM_019577
Ccl24
chemokine (C-C motif) ligand 24
chr7_+_104601713 1.473 NM_001010826
NM_001012434
Kctd14

potassium channel tetramerisation domain containing 14

chr14_+_33599148 1.473 NM_001163616
1810011H11Rik
RIKEN cDNA 1810011H11 gene
chr12_+_11272852 1.465 Smc6
structural maintenance of chromosomes 6
chr4_-_94645735 1.430 NM_177239
Mysm1
myb-like, SWIRM and MPN domains 1
chr15_-_75956971 1.381 NM_001142968
BC024139
cDNA sequence BC024139
chr7_-_25101619 1.369 NM_009568
Zfp94
zinc finger protein 94
chr19_-_45634998 1.347 NM_020032
Poll
polymerase (DNA directed), lambda
chr2_-_7317513 1.329 NM_001110232
Celf2
CUGBP, Elav-like family member 2
chr15_-_9678531 1.323 NM_177123
Spef2
sperm flagellar 2
chr3_+_96836314 1.306 NM_008121
Gja5
gap junction protein, alpha 5
chr7_+_109358966 1.304 Pgap2
post-GPI attachment to proteins 2
chr2_-_164104007 1.281 NM_009300
Svs4
seminal vesicle secretory protein 4
chr9_-_35007875 1.252 NM_001177845
Tirap
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
chr11_+_67346499 1.251 NM_008088
Gas7
growth arrest specific 7
chr6_+_57530968 1.249 NM_025992
Herc6
hect domain and RLD 6
chr7_+_51471844 1.249 NM_008456
Klk1b5
kallikrein 1-related peptidase b5
chr4_-_142802606 1.233 NM_001081355
Prdm2
PR domain containing 2, with ZNF domain
chrX_-_5897723 1.196 NM_009757
Bmp15
bone morphogenetic protein 15
chr10_-_105278374 1.154 NM_207522
BC067068
cDNA sequence BC067068
chr7_+_3581586 1.140 NM_001159714
NM_027328
Prpf31

PRP31 pre-mRNA processing factor 31 homolog (yeast)

chr7_-_149361909 1.129 NM_027844
Krtap5-2
keratin associated protein 5-2
chr15_+_10153734 1.114 Prlr
prolactin receptor
chr13_+_22036962 1.097 NM_183014
Zfp184
zinc finger protein 184 (Kruppel-like)
chr15_+_25870456 1.086 NM_025459
Fam134b
family with sequence similarity 134, member B
chr14_+_21113911 1.066 NM_026341
Nudt13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr15_-_80935436 1.047 NM_153049
Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr15_-_76447278 1.000 NM_028064
Slc39a4
solute carrier family 39 (zinc transporter), member 4
chr12_+_36652206 0.980 NM_207531
Agr3
anterior gradient homolog 3 (Xenopus laevis)
chr2_+_162760505 0.979


chr3_-_92242684 0.969 NM_009265
Sprr1b
small proline-rich protein 1B
chr7_-_4817730 0.966 Isoc2b
isochorismatase domain containing 2b
chrX_-_70488358 0.952 NM_183094
Xlr4c
X-linked lymphocyte-regulated 4C
chr16_-_11220854 0.940 Gspt1
G1 to S phase transition 1
chr9_-_44152208 0.926 Hmbs
hydroxymethylbilane synthase
chr14_-_70577478 0.874 NM_145978
Pdlim2
PDZ and LIM domain 2
chr5_+_136470670 0.874 NM_023742
Dtx2
deltex 2 homolog (Drosophila)
chr2_+_162760289 0.867 Srsf6
serine/arginine-rich splicing factor 6
chr11_+_101037415 0.864 NM_016782
Cntnap1
contactin associated protein-like 1
chr4_+_102242664 0.835 NM_001177980
Pde4b
phosphodiesterase 4B, cAMP specific
chr17_-_47147441 0.829 NM_001177374
NM_146078
Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr13_+_35016277 0.805 NM_025750
4933417A18Rik
RIKEN cDNA 4933417A18 gene
chr7_-_115210309 0.780 NM_020291
Olfr480
olfactory receptor 480
chr2_+_25279213 0.771 NM_001177366
NM_001177367
NM_013524
Fut7


fucosyltransferase 7


chr16_-_93930061 0.768 NM_001165926
Cldn14
claudin 14
chr6_-_41264706 0.739 NM_001003405
Try5
trypsin 5
chr4_+_120339167 0.711 NM_019563
Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr18_-_32071556 0.704 NM_026006
Sft2d3
SFT2 domain containing 3
chr7_-_3581429 0.694 NM_023524
Tfpt
TCF3 (E2A) fusion partner
chr17_+_8627287 0.694 NM_009309
T
brachyury
chr4_+_45903174 0.693 NM_198660
E230008N13Rik
RIKEN cDNA E230008N13 gene
chr7_-_4610551 0.687 NM_172894
Ppp6r1
protein phosphatase 6, regulatory subunit 1
chr5_+_88095232 0.687 NM_007784
Csn1s1
casein alpha s1
chrX_-_7829333 0.683 NM_133991
Ftsj1
FtsJ homolog 1 (E. coli)
chr2_-_91803660 0.682 NM_138306
Dgkz
diacylglycerol kinase zeta
chr17_+_25270317 0.666 NM_011930
Clcn7
chloride channel 7
chr7_-_116875215 0.639 NM_020051
Ascl3
achaete-scute complex homolog 3 (Drosophila)
chr14_-_119076152 0.628 NM_001163675
Abcc4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr6_+_40914752 0.621 NM_023707
1810009J06Rik
RIKEN cDNA 1810009J06 gene
chr16_+_30008752 0.617 4632428C04Rik
RIKEN cDNA 4632428C04 gene
chr13_-_67182447 0.613 NM_001012448
Zfp708
zinc finger protein 708
chr1_+_133534852 0.591 NM_007799
Ctse
cathepsin E
chr7_+_125884231 0.576 9030624J02Rik
RIKEN cDNA 9030624J02 gene
chr8_+_80073295 0.569 NM_001081240
Prmt10
protein arginine methyltransferase 10 (putative)
chr16_-_16504310 0.543 NM_139233
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr7_-_3629631 0.542 Mboat7
membrane bound O-acyltransferase domain containing 7
chr6_-_28399248 0.529 NM_001159925
NM_001159926
NM_011038
Pax4


paired box gene 4


chr3_-_89568298 0.520 Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr8_+_80073336 0.508 Prmt10
protein arginine methyltransferase 10 (putative)
chr19_+_46130978 0.476 NM_001081214
Pprc1
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr2_-_73052484 0.452 NM_025942
NM_030091
Ola1

Obg-like ATPase 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.22 3.51e-05 GO:0002376 immune system process
4.33 7.71e-04 GO:0006955 immune response
5.89 7.73e-04 GO:0034097 response to cytokine stimulus
3.49 9.68e-04 GO:0002682 regulation of immune system process
4.17 1.25e-03 GO:0002684 positive regulation of immune system process
2.26 4.58e-03 GO:0006950 response to stress
3.46 7.26e-03 GO:0006952 defense response
10.97 1.31e-02 GO:0002685 regulation of leukocyte migration
14.79 1.54e-02 GO:0030890 positive regulation of B cell proliferation
5.96 1.64e-02 GO:0002696 positive regulation of leukocyte activation
5.73 2.23e-02 GO:0045087 innate immune response
5.73 2.23e-02 GO:0050867 positive regulation of cell activation
4.68 4.55e-02 GO:0046649 lymphocyte activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.23 3.92e-02 GO:0009897 external side of plasma membrane

Nothing significant found in function category.