Motif ID: TGIF1.p2

Z-value: 2.110


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
Tgif1 21815 TGFB-induced factor homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1chr17_-_71199129,
chr17_-_71200462,
chr17_-_71201055,
chr17_-_71202829,
chr17_-_71196116
-0.473.5e-11Click!


Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_114280434 20.752 NM_009151
Selplg
selectin, platelet (p-selectin) ligand
chr7_-_110962416 18.964 NM_008220
NM_016956
Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr16_-_19983049 18.732 NM_183390
Klhl6
kelch-like 6 (Drosophila)
chr7_-_110976438 17.539 Hbb-b1
hemoglobin, beta adult major chain
chr7_-_110976439 16.855 Hbb-b1
hemoglobin, beta adult major chain
chr15_-_78403110 16.727 NM_009008
Rac2
RAS-related C3 botulinum substrate 2
chr13_+_83643032 15.191 NM_001170537
NM_025282
Mef2c

myocyte enhancer factor 2C

chr1_-_182126032 15.018 NM_023341
Adck3
aarF domain containing kinase 3
chr8_+_58773380 13.965 Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr7_-_110976499 13.903 Hbb-b1
hemoglobin, beta adult major chain
chr8_+_58773321 13.844 NM_008278
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr7_-_110962324 13.647 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr4_+_130469048 13.482 Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_48058102 13.316 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_66991625 12.648 NM_021285
Myl1
myosin, light polypeptide 1
chr4_+_130469187 12.523 NM_010686
Laptm5
lysosomal-associated protein transmembrane 5
chr8_+_83017933 12.199 NM_010369
Gypa
glycophorin A
chr14_+_56194510 12.120 NM_026808
Fitm1
fat storage-inducing transmembrane protein 1
chr7_-_106859849 11.851 NM_175316
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr15_-_76853069 11.809 NM_001164048
NM_001164047
Mb

myoglobin

chr14_+_52473672 11.708 NM_017385
Ear7
eosinophil-associated, ribonuclease A family, member 7
chr6_+_88674821 11.546 Mgll
monoglyceride lipase
chr1_-_66991580 11.520 Myl1
myosin, light polypeptide 1
chr11_+_33946927 11.436 Lcp2
lymphocyte cytosolic protein 2
chr14_+_44680318 11.399 NM_007895
NM_001012766
NM_017388
BC151093
Ear2
Ear12
Ear3
cDNA sequence BC151093
eosinophil-associated, ribonuclease A family, member 2
eosinophil-associated, ribonuclease A family, member 12
eosinophil-associated, ribonuclease A family, member 3
chr11_-_72303447 11.379 Spns2
spinster homolog 2 (Drosophila)
chr17_-_48572043 11.229 NM_009694
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr17_-_48571942 11.116 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr8_+_24249481 10.970 Ank1
ankyrin 1, erythroid
chr7_-_110976314 10.937 Hbb-b1
Hbb-b2
hemoglobin, beta adult major chain
hemoglobin, beta adult minor chain
chr2_-_76820599 10.916 NM_011652
NM_028004
Ttn

titin

chr15_-_66644127 10.751 NM_009192
Sla
src-like adaptor
chr11_+_83560437 10.542 NM_183249
1100001G20Rik
RIKEN cDNA 1100001G20 gene
chr2_+_150396150 10.500 NM_009977
Cst7
cystatin F (leukocystatin)
chr7_+_129432585 10.474 NM_008855
Prkcb
protein kinase C, beta
chr7_-_90883999 10.464 NM_010551
Il16
interleukin 16
chr2_-_132403964 10.427 NM_001042671
NM_001042672
NM_028802
Gpcpd1


glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)


chr2_-_132403832 10.261 Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr6_+_88674398 10.256 NM_001166249
NM_011844
Mgll

monoglyceride lipase

chr7_-_20283542 10.081 Apoe
apolipoprotein E
chr4_-_133650937 10.058 NM_013706
Cd52
CD52 antigen
chr11_-_6420904 9.971 Myo1g
myosin IG
chr3_-_88259594 9.920 Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_+_114751585 9.837 Cd300a
CD300A antigen
chr6_+_68375560 9.761 Igkv16-104
immunoglobulin kappa variable 16-104
chr16_+_18777032 9.657 Cldn5
claudin 5
chr7_-_133848235 9.618 NM_009898
Coro1a
coronin, actin binding protein 1A
chr11_-_72303293 9.611 NM_153060
Spns2
spinster homolog 2 (Drosophila)
chr14_-_44501032 9.540 NM_053112
Ear10
eosinophil-associated, ribonuclease A family, member 10
chr10_+_79479416 9.441 NM_001142701
Hmha1
histocompatibility (minor) HA-1
chr3_-_88259621 9.119 Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_-_50788445 9.053 Cd33
CD33 antigen
chr3_-_88259682 9.016 NM_013658
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr17_+_43705510 8.985 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_-_66644199 8.872 Sla
src-like adaptor
chr5_-_25004519 8.809 Mll3
myeloid/lymphoid or mixed-lineage leukemia 3
chr7_-_50788540 8.686 NM_001111058
NM_021293
Cd33

CD33 antigen

chr13_+_83803830 8.427 Mef2c
myocyte enhancer factor 2C
chr7_+_135273060 8.413 NM_021334
Itgax
integrin alpha X
chr3_+_17695743 8.408 6430547I21Rik
RIKEN cDNA 6430547I21 gene
chr13_-_37141055 8.381 NM_028784
F13a1
coagulation factor XIII, A1 subunit
chr1_-_130488785 8.348 NM_009911
Cxcr4
chemokine (C-X-C motif) receptor 4
chr11_+_82724754 8.220 NM_178680
Unc45b
unc-45 homolog B (C. elegans)
chr16_+_23146631 8.169 Adipoq
adiponectin, C1Q and collagen domain containing
chr11_+_83777922 8.134 NM_001115009
NM_194341
Synrg

synergin, gamma

chr3_-_115417847 8.091 S1pr1
sphingosine-1-phosphate receptor 1
chr10_-_128181069 8.066 NM_016811
Dgka
diacylglycerol kinase, alpha
chr10_-_88067758 8.056 NM_175418
Mybpc1
myosin binding protein C, slow-type
chr15_-_79572885 8.050 NM_194342
Sun2
Sad1 and UNC84 domain containing 2
chr16_+_18776936 8.030 NM_013805
Cldn5
claudin 5
chr7_+_96552955 7.946 Fzd4
frizzled homolog 4 (Drosophila)
chr7_-_148086285 7.940 Cox8b
cytochrome c oxidase, subunit VIIIb
chr16_+_23146608 7.926 NM_009605
Adipoq
adiponectin, C1Q and collagen domain containing
chr14_+_56194622 7.899 Fitm1
fat storage-inducing transmembrane protein 1
chr15_-_103395483 7.866 NM_008134
Glycam1
glycosylation dependent cell adhesion molecule 1
chr1_-_87500465 7.863 NM_175397
Sp110
Sp110 nuclear body protein
chr12_+_103521355 7.847 Rin3
Ras and Rab interactor 3
chr16_+_18776955 7.832 Cldn5
claudin 5
chr8_+_56040553 7.796 Gpm6a
glycoprotein m6a
chr4_+_124419115 7.778 NM_008385
Inpp5b
inositol polyphosphate-5-phosphatase B
chrX_+_13209894 7.774 NM_011823
Gpr34
G protein-coupled receptor 34
chr9_+_51021793 7.740 NM_011136
Pou2af1
POU domain, class 2, associating factor 1
chr7_-_80703275 7.702 1810026B05Rik
RIKEN cDNA 1810026B05 gene
chr4_-_43059017 7.605 NM_172691
B230312A22Rik
RIKEN cDNA B230312A22 gene
chr2_+_79095582 7.566 NM_010576
Itga4
integrin alpha 4
chr2_+_43604343 7.460 NM_153820
NM_001025377
Arhgap15

Rho GTPase activating protein 15

chr13_-_41454358 7.399 NM_017464
Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr3_-_40650624 7.316 NM_028140
Mfsd8
major facilitator superfamily domain containing 8
chr12_-_115526405 7.106 Igh-VJ558
Igh-2
LOC432699
immunoglobulin heavy chain (J558 family)
immunoglobulin heavy chain 2 (serum IgA)
VH gene product
chr3_-_115417932 7.091 NM_007901
S1pr1
sphingosine-1-phosphate receptor 1
chr3_-_92582820 7.075 NM_029667
Lce1i
late cornified envelope 1I
chr15_-_12479631 7.066 Pdzd2
PDZ domain containing 2
chr12_+_103521251 7.048 NM_177620
Rin3
Ras and Rab interactor 3
chr15_-_41700964 6.997 NM_175456
Abra
actin-binding Rho activating protein
chr6_+_97757012 6.981 NM_001113198
Mitf
microphthalmia-associated transcription factor
chr15_+_81633102 6.948 NM_153484
Tef
thyrotroph embryonic factor
chr15_+_82129383 6.938 NM_029066
Wbp2nl
WBP2 N-terminal like
chr10_+_41530379 6.867 NM_001162908
Sesn1
sestrin 1
chr4_-_43058685 6.843 B230312A22Rik
RIKEN cDNA B230312A22 gene
chr12_+_103521406 6.783 Rin3
Ras and Rab interactor 3
chr17_+_87153083 6.722 NM_010137
Epas1
endothelial PAS domain protein 1
chr7_-_139978601 6.699 NM_175268
Fam53b
family with sequence similarity 53, member B
chr1_+_94807324 6.673 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr8_+_56040445 6.667 Gpm6a
glycoprotein m6a
chr16_-_46120221 6.621 NM_032465
Cd96
CD96 antigen
chr11_+_78640059 6.560 NM_001076681
1810012P15Rik
RIKEN cDNA 1810012P15 gene
chr17_+_35516558 6.482 NM_001143689
H2-Gs10
MHC class I like protein GS10
chr3_-_115417685 6.461 S1pr1
sphingosine-1-phosphate receptor 1
chr11_+_58020859 6.419 Igtp
interferon gamma induced GTPase
chr3_-_112959644 6.360 NM_001190403
NM_001190404
Amy2b

amylase 2b

chr15_-_5058532 6.337 NM_001163138
Card6
caspase recruitment domain family, member 6
chr11_+_100442831 6.239 Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr7_+_96552871 6.214 NM_008055
Fzd4
frizzled homolog 4 (Drosophila)
chr4_+_140977613 6.072 Hspb7
heat shock protein family, member 7 (cardiovascular)
chr14_-_44397257 6.026 NM_007894
Ear1
eosinophil-associated, ribonuclease A family, member 1
chr14_+_56194658 6.004 Fitm1
fat storage-inducing transmembrane protein 1
chr17_+_75835208 6.004 NM_001166493
Rasgrp3
RAS, guanyl releasing protein 3
chr2_+_69508174 6.002 NM_001081087
Kbtbd10
kelch repeat and BTB (POZ) domain containing 10
chr17_-_37712365 5.980 NM_146289
Olfr113
olfactory receptor 113
chr16_-_89818596 5.972 NM_001145887
Tiam1
T-cell lymphoma invasion and metastasis 1
chr6_+_48689045 5.914 NM_008376
NM_175860
Gimap1

GTPase, IMAP family member 1

chr8_+_56040080 5.813 NM_153581
Gpm6a
glycoprotein m6a
chr6_+_50060895 5.740 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr3_-_113094211 5.733 NM_001160150
NM_001160151
NM_001160152
NM_001042711
Amy2a4
Amy2a3
Amy2a2
Amy2a5
amylase 2a4
amylase 2a3
amylase 2a2
amylase 2a5
chr5_-_44617844 5.733 NM_173764
Tapt1
transmembrane anterior posterior transformation 1
chr11_+_78640103 5.730 1810012P15Rik
RIKEN cDNA 1810012P15 gene
chr17_-_27304602 5.725 NM_173027
Ip6k3
inositol hexaphosphate kinase 3
chr8_+_122638031 5.717 NM_001163761
NM_001163762
NM_172286
6430548M08Rik


RIKEN cDNA 6430548M08 gene


chr3_-_116671573 5.695 Palmd
palmdelphin
chr7_-_90803895 5.632 Il16
interleukin 16
chr14_-_73725546 5.565 Rb1
retinoblastoma 1
chr4_-_22415444 5.451 Pou3f2
POU domain, class 3, transcription factor 2
chr2_-_160192737 5.439 Mafb
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
chr14_+_56179739 5.437 NM_001199009
Dcaf11
DDB1 and CUL4 associated factor 11
chr11_+_33947115 5.418 NM_010696
Lcp2
lymphocyte cytosolic protein 2
chr1_+_137949360 5.414 NM_001081023
NM_014193
Cacna1s

calcium channel, voltage-dependent, L type, alpha 1S subunit

chr2_-_113878535 5.379 NM_009608
Actc1
actin, alpha, cardiac muscle 1
chr6_+_55286292 5.349 NM_007472
Aqp1
aquaporin 1
chr5_-_25004598 5.337 NM_001081383
Mll3
myeloid/lymphoid or mixed-lineage leukemia 3
chr12_+_113919213 5.294 Zbtb42
zinc finger and BTB domain containing 42
chrX_+_154137193 5.286 Smpx
small muscle protein, X-linked
chr8_-_63461923 5.253 Clcn3
chloride channel 3
chr11_-_108205199 5.242 NM_011101
Prkca
protein kinase C, alpha
chr10_+_115738429 5.225 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr17_+_35561811 5.216 NM_207648
H2-Q6
histocompatibility 2, Q region locus 6
chr11_+_82930294 5.175 NM_011407
Slfn1
schlafen 1
chr10_-_80131318 5.169 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr8_+_47556503 5.147 Acsl1
acyl-CoA synthetase long-chain family member 1
chr17_+_43705388 5.136 NM_013737
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr7_+_63023547 5.090 NM_178706
Siglech
sialic acid binding Ig-like lectin H
chr7_+_29225955 5.083 NM_001039192
Gmfg
glia maturation factor, gamma
chr1_+_155747072 5.067 NM_008131
Glul
glutamate-ammonia ligase (glutamine synthetase)
chr17_+_35607032 5.066 NM_010391
H2-Q10
histocompatibility 2, Q region locus 10
chr7_+_138554108 5.064 NM_025826
Acadsb
acyl-Coenzyme A dehydrogenase, short/branched chain
chr11_-_86539846 5.051 Cltc
clathrin, heavy polypeptide (Hc)
chr12_+_111723922 5.045 NM_001081457
NM_001081458
NM_012023
Ppp2r5c


protein phosphatase 2, regulatory subunit B (B56), gamma isoform


chr4_+_140977621 5.008 Hspb7
heat shock protein family, member 7 (cardiovascular)
chr17_+_35400056 5.004 H2-D1
H2-L
histocompatibility 2, D region locus 1
histocompatibility 2, D region
chr7_+_138554180 4.959 Acadsb
acyl-Coenzyme A dehydrogenase, short/branched chain
chr4_+_147374850 4.948 NM_008725
Nppa
natriuretic peptide type A
chr3_-_113277601 4.947 NM_007446
Amy1
amylase 1, salivary
chr2_-_11423651 4.922 Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr3_-_144382959 4.912 NM_019464
Sh3glb1
SH3-domain GRB2-like B1 (endophilin)
chr5_+_137729501 4.885 NM_009599
Ache
acetylcholinesterase
chr15_+_81297235 4.876 Rbx1
ring-box 1
chrX_+_154137049 4.863 NM_025357
Smpx
small muscle protein, X-linked
chr13_+_24706474 4.837 NM_178658
Fam65b
family with sequence similarity 65, member B
chrX_+_137491455 4.824 NM_174875
Atg4a
autophagy-related 4A (yeast)
chr6_+_49269294 4.803 Ccdc126
coiled-coil domain containing 126
chr9_+_64659238 4.792 Dennd4a
DENN/MADD domain containing 4A
chr6_-_106750030 4.780 NM_021449
NM_175357
Crbn

cereblon

chrX_+_154137114 4.772 Smpx
small muscle protein, X-linked
chr11_+_114751354 4.731 NM_170758
Cd300a
CD300A antigen
chr11_-_96976562 4.700 NM_019507
Tbx21
T-box 21
chr8_+_56040211 4.691 Gpm6a
glycoprotein m6a
chr17_+_44325518 4.690 NM_172621
Clic5
chloride intracellular channel 5
chr10_+_122116066 4.639 Ppm1h
protein phosphatase 1H (PP2C domain containing)
chr1_-_164408133 4.617 NM_001038619
NM_172646
Dnm3

dynamin 3

chr2_+_32576591 4.593 NM_013781
Sh2d3c
SH2 domain containing 3C
chr6_+_38868942 4.586 NM_011539
Tbxas1
thromboxane A synthase 1, platelet
chr7_-_56892061 4.575 NM_001005232
Dbx1
developing brain homeobox 1
chr1_-_164408123 4.566 Dnm3
dynamin 3
chr17_+_35399970 4.563 H2-D1
histocompatibility 2, D region locus 1
chr17_+_35400038 4.537 NM_010380
H2-D1
histocompatibility 2, D region locus 1
chr17_+_35607037 4.522 H2-Q10
histocompatibility 2, Q region locus 10
chr4_-_60594959 4.517 NM_001122647
Mup10
LOC100048884
Mup1
major urinary protein 10
novel member of the major urinary protein (Mup) gene family
major urinary protein 1
chr7_-_144506091 4.507 Ebf3
early B-cell factor 3
chr7_-_111507159 4.484 NM_175648
Trim30b
tripartite motif-containing 30B
chr19_-_21467250 4.479 Gda
guanine deaminase
chr3_+_52153283 4.475 Foxo1
forkhead box O1
chr7_-_148086341 4.463 NM_007751
Cox8b
cytochrome c oxidase, subunit VIIIb
chr6_+_88674697 4.462 NM_001166250
NM_001166251
Mgll

monoglyceride lipase

chr1_-_182175890 4.454 NM_011183
Psen2
presenilin 2
chr6_-_136889984 4.425 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_-_155999858 4.397 Rbm39
RNA binding motif protein 39
chr18_+_63868337 4.395 NM_001014981
Wdr7
WD repeat domain 7
chr1_-_164408008 4.388 Dnm3
dynamin 3
chr7_+_107621474 4.382 NM_009464
Ucp3
uncoupling protein 3 (mitochondrial, proton carrier)
chr14_+_28051224 4.339 NM_027871
Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chr2_-_126444378 4.335 NM_008230
Hdc
histidine decarboxylase

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.34 5.29e-05 GO:0051179 localization
1.37 1.75e-04 GO:0051234 establishment of localization
1.36 3.18e-04 GO:0006810 transport
2.60 4.81e-03 GO:0019216 regulation of lipid metabolic process
1.57 1.03e-02 GO:0002376 immune system process
1.39 1.09e-02 GO:0065008 regulation of biological quality
1.30 1.27e-02 GO:0048518 positive regulation of biological process
1.27 1.91e-02 GO:0032502 developmental process
1.61 2.46e-02 GO:0051049 regulation of transport
1.31 3.68e-02 GO:0048731 system development
1.50 3.81e-02 GO:0032879 regulation of localization
4.19 3.90e-02 GO:0006941 striated muscle contraction
2.26 4.41e-02 GO:0008015 blood circulation
1.29 4.60e-02 GO:0048856 anatomical structure development
2.24 4.92e-02 GO:0003013 circulatory system process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.27 2.70e-04 GO:0071944 cell periphery
1.26 1.07e-03 GO:0005886 plasma membrane
1.11 2.14e-03 GO:0005622 intracellular
1.19 3.34e-03 GO:0044444 cytoplasmic part
1.69 6.81e-03 GO:0031988 membrane-bounded vesicle
1.10 7.92e-03 GO:0044424 intracellular part
1.71 8.28e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
2.63 9.88e-03 GO:0030016 myofibril
1.34 1.60e-02 GO:0044459 plasma membrane part
1.13 1.93e-02 GO:0005737 cytoplasm
1.55 2.49e-02 GO:0031410 cytoplasmic vesicle
2.59 2.75e-02 GO:0044449 contractile fiber part
2.41 3.73e-02 GO:0043292 contractile fiber
1.80 4.35e-02 GO:0044456 synapse part
2.66 4.36e-02 GO:0030017 sarcomere

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.11 1.25e-03 GO:0005488 binding
1.19 2.32e-03 GO:0005515 protein binding
1.78 2.58e-02 GO:0030695 GTPase regulator activity
1.76 2.93e-02 GO:0060589 nucleoside-triphosphatase regulator activity