Motif ID: VSX1,2.p2

Z-value: 0.479


Transcription factors associated with VSX1,2.p2:

Gene SymbolEntrez IDGene Name
Vsx1 114889 visual system homeobox 1 homolog (zebrafish)
Vsx2 12677 visual system homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2chr12_+_859107770.263.6e-04Click!
Vsx1chr2_-_1505147170.206.2e-03Click!


Activity profile for motif VSX1,2.p2.

activity profile for motif VSX1,2.p2


Sorted Z-values histogram for motif VSX1,2.p2

Sorted Z-values for motif VSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of VSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_97028409 11.883 Lum
lumican
chr2_+_20211539 6.004 NM_001081006
Etl4
enhancer trap locus 4
chr4_+_133624366 4.680 NM_001162970
Aim1l
absent in melanoma 1-like
chr3_-_27316628 3.767 Fndc3b
fibronectin type III domain containing 3B
chr9_-_104028940 3.286 NM_145700
Acad11
Ccrl1
acyl-Coenzyme A dehydrogenase family, member 11
chemokine (C-C motif) receptor-like 1
chr4_-_14548903 2.922 NM_145947
Slc26a7
solute carrier family 26, member 7
chr1_-_72920776 2.396 Igfbp5
insulin-like growth factor binding protein 5
chr2_-_168592528 2.340 NM_175303
NM_201395
NM_201396
Sall4


sal-like 4 (Drosophila)


chr19_+_38207270 2.259 NM_001170959
NM_033614
Pde6c

phosphodiesterase 6C, cGMP specific, cone, alpha prime

chr10_-_26095736 2.251 L3mbtl3
l(3)mbt-like 3 (Drosophila)
chr7_+_31536489 2.169 NM_001083903
NM_172205
Sbsn

suprabasin

chr8_+_11448095 2.168 Col4a2
collagen, type IV, alpha 2
chr8_-_11199802 2.097 Col4a1
collagen, type IV, alpha 1
chr8_+_46744023 1.860 Sorbs2
sorbin and SH3 domain containing 2
chr5_+_140019846 1.752 NM_013702
Uncx
UNC homeobox
chr4_+_145260599 1.588 NM_001103158
Gm13242
predicted gene 13242
chr2_-_25325248 1.533 NM_008963
Ptgds
prostaglandin D2 synthase (brain)
chr11_+_60351159 1.530 NM_172943
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr6_+_77193078 1.512 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chrX_+_16196823 1.494 NM_173740
Maoa
monoamine oxidase A
chr5_-_113510602 1.237 NM_001159650
NM_021352
Crybb3

crystallin, beta B3

chr9_+_43118845 1.091 NM_023655
Trim29
tripartite motif-containing 29
chr4_+_145850602 1.007 NM_001177767
NM_009051
Gm13138
Rex2
predicted gene 13138
reduced expression 2
chr4_+_146395958 1.007 NM_001177767
NM_009051
Gm13138
Rex2
predicted gene 13138
reduced expression 2
chr7_-_141568510 0.974 NM_001081331
D7Ertd443e
DNA segment, Chr 7, ERATO Doi 443, expressed
chr4_+_146124224 0.961 NM_001177546
Zfp600
zinc finger protein 600
chr10_+_39332934 0.921 Traf3ip2
TRAF3 interacting protein 2
chr5_-_86802390 0.920 NM_145561
Tmprss11d
transmembrane protease, serine 11d
chr6_-_136730254 0.889 NM_001127318
NM_145067
Gucy2c

guanylate cyclase 2c

chr16_+_45094196 0.847 Ccdc80
coiled-coil domain containing 80
chr18_+_57628139 0.839 NM_001134697
Ctxn3
cortexin 3
chr3_+_159502646 0.826 NM_026582
Wls
wntless homolog (Drosophila)
chr3_-_49561168 0.807 NM_130448
Pcdh18
protocadherin 18
chr9_+_31923720 0.796 NM_001195632
Arhgap32
Rho GTPase activating protein 32
chr7_-_123174560 0.778 NM_001025560
Sox6
SRY-box containing gene 6
chr9_-_91255831 0.777 Zic1
zinc finger protein of the cerebellum 1
chr2_+_121184334 0.753 NM_009897
Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr1_+_24184448 0.742 NM_007740
Col9a1
collagen, type IX, alpha 1
chr10_+_97110043 0.727 Epyc
epiphycan
chr6_-_68967061 0.723


chr18_-_35881144 0.691 NM_001033141
Ecscr
endothelial cell-specific chemotaxis regulator
chr7_+_53631843 0.682 NM_010866
Myod1
myogenic differentiation 1
chr10_+_39332739 0.676 NM_134000
Traf3ip2
TRAF3 interacting protein 2
chr6_-_69367406 0.673 Igkv4-68
immunoglobulin kappa variable 4-68
chr10_+_73284612 0.672 NM_001142735
NM_001142736
NM_001142737
NM_001142738
NM_001142739
NM_001142740
NM_001142741
NM_001142742
NM_001142743
NM_001142746
NM_001142747
NM_001142748
NM_001142760
NM_023115
Pcdh15













protocadherin 15













chr6_-_69494873 0.656 Igkv4-57-1
immunoglobulin kappa variable 4-57-1
chr5_+_90919768 0.634 Afp
alpha fetoprotein
chr5_+_90919758 0.634 Afp
alpha fetoprotein
chr12_-_105711324 0.626 NM_010351
Gsc
goosecoid homeobox
chr4_-_147016606 0.616 NM_145078
2610305D13Rik
RIKEN cDNA 2610305D13 gene
chr2_+_103909961 0.567 Cd59b
CD59b antigen
chr1_-_72921098 0.552 Igfbp5
insulin-like growth factor binding protein 5
chr1_+_174486066 0.547 NM_177723
Vsig8
V-set and immunoglobulin domain containing 8
chr1_+_40381420 0.537 NM_133193
Il1rl2
interleukin 1 receptor-like 2
chr6_-_130287518 0.537 NM_010648
Klra3
killer cell lectin-like receptor, subfamily A, member 3
chr17_+_17539832 0.533 Lix1
limb expression 1 homolog (chicken)
chr12_-_11215753 0.528 NM_019544
Msgn1
mesogenin 1
chr19_+_56798916 0.478 Adrb1
adrenergic receptor, beta 1
chr5_-_84846348 0.465 NM_007937
Epha5
Eph receptor A5
chr12_+_110783786 0.462 Meg3
maternally expressed 3
chr2_+_151736942 0.403 NM_009641
Angpt4
angiopoietin 4
chr6_-_116666759 0.389 NM_178768
Tmem72
transmembrane protein 72
chr2_+_3341402 0.344 NM_001110214
NM_146114
NM_175683
Dclre1c


DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)


chr13_-_33250219 0.341 NM_011453
Serpinb9c
serine (or cysteine) peptidase inhibitor, clade B, member 9c
chr5_+_90919739 0.334 NM_007423
Afp
alpha fetoprotein
chr6_+_77192839 0.329 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr4_-_147183894 0.314 NM_001127189
Gm13157
2610036A22Rik
predicted gene 13157
RIKEN cDNA 2610036A22 gene
chr11_-_65083322 0.307 Myocd
myocardin
chr15_-_8660729 0.281 NM_148938
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_57063418 0.281 NM_053231
Vmn1r10
vomeronasal 1 receptor 10
chr11_-_99184254 0.278 NM_133730
Krt25
keratin 25
chr4_+_146927385 0.268 NM_001014397
Gm13154
predicted gene 13154
chr5_-_91069499 0.259 NM_028478
Rassf6
Ras association (RalGDS/AF-6) domain family member 6
chr6_-_130143018 0.246 NM_010651
Klra5
Klra6
Klra9
killer cell lectin-like receptor, subfamily A, member 5
killer cell lectin-like receptor, subfamily A, member 6
killer cell lectin-like receptor subfamily A, member 9
chr1_-_132586370 0.238 Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr2_-_164410946 0.234 NM_001033240
Wfdc6a
WAP four-disulfide core domain 6A
chr11_-_48864726 0.231 NM_173434
9930111J21Rik2
RIKEN cDNA 9930111J21 gene 2
chr3_-_130433225 0.230 NM_026724
Rpl34-ps1
Rpl34
ribosomal protein L34, pseudogene 1
ribosomal protein L34
chr4_-_132066370 0.217 NM_144907
Sesn2
sestrin 2
chr10_+_98453513 0.211 Atp2b1
ATPase, Ca++ transporting, plasma membrane 1
chr12_+_56699903 0.201 NM_020287
Insm2
insulinoma-associated 2
chr17_+_17539908 0.191 Lix1
limb expression 1 homolog (chicken)
chr11_-_94693315 0.186 NM_001163172
Tmem92-ps
transmembrane protein 92, pseudogene
chr17_+_35670145 0.183 NM_020576
Psors1c2
psoriasis susceptibility 1 candidate 2 (human)
chr5_-_84846256 0.175 Epha5
Eph receptor A5
chr10_+_98725871 0.171 Dusp6
dual specificity phosphatase 6
chr15_+_101303908 0.160 NM_010667
Krt86
keratin 86
chr3_+_92748407 0.154 NM_033175
Lce3c
late cornified envelope 3C
chr16_-_92400226 0.138 NM_019466
Rcan1
regulator of calcineurin 1
chr10_+_127335573 0.118 NM_027301
Sdr9c7
4short chain dehydrogenase/reductase family 9C, member 7
chr15_-_101573522 0.118 NM_019956
Krt71
keratin 71
chr4_+_129138924 0.110 Bsdc1
BSD domain containing 1
chr6_+_57087346 0.107 NM_053233
Vmn1r11
vomeronasal 1 receptor 11
chr19_-_55315725 0.104 NM_001081076
Gucy2g
guanylate cyclase 2g
chr15_-_101632762 0.096 NM_212485
Krt73
keratin 73
chr15_+_4677207 0.093 NM_016704
C6
complement component 6
chr11_-_69648350 0.088 NM_198862
Nlgn2
neuroligin 2
chr13_-_16115192 0.086 B230303A05Rik
RIKEN cDNA B230303A05 gene
chr10_-_106922986 0.064 NM_008656
Myf5
myogenic factor 5
chr17_+_26792031 0.058 Ergic1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr3_+_93272675 0.053 NM_027762
Tchhl1
trichohyalin-like 1
chr6_+_57020888 0.032 NM_134185
Vmn1r9
vomeronasal 1 receptor 9
chr3_-_115956312 0.019 NM_022427
Gpr88
G-protein coupled receptor 88
chrM_+_13543 0.012


chr4_+_110070336 0.008 NM_001048189
NM_030231
Agbl4

ATP/GTP binding protein-like 4

chr1_+_179659944 0.005 NM_027077
1700016C15Rik
RIKEN cDNA 1700016C15 gene

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
13.85 1.30e-02 GO:0051147 regulation of muscle cell differentiation
6.42 1.49e-02 GO:0061061 muscle structure development
3.40 2.46e-02 GO:0009888 tissue development
134.68 3.13e-02 GO:0001969 regulation of activation of membrane attack complex
8.04 4.41e-02 GO:0042692 muscle cell differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
31.09 6.21e-04 GO:0005581 collagen
10.37 2.00e-03 GO:0044420 extracellular matrix part
3.07 1.37e-02 GO:0044421 extracellular region part
67.35 2.92e-02 GO:0005587 collagen type IV
67.35 2.92e-02 GO:0030935 sheet-forming collagen
4.99 4.15e-02 GO:0005578 proteinaceous extracellular matrix
18.95 4.25e-02 GO:0045095 keratin filament

Nothing significant found in function category.