Motif ID: ONECUT1,2.p2

Z-value: 2.007


Transcription factors associated with ONECUT1,2.p2:

Gene SymbolEntrez IDGene Name
ONECUT1 3175 one cut homeobox 1
ONECUT2 9480 one cut homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ONECUT2hg19_v1_chr18_+_55102777_551029540.631.2e-04Click!
ONECUT1hg19_v1_chr15_-_53082087_530823020.621.5e-04Click!


Activity profile for motif ONECUT1,2.p2.

activity profile for motif ONECUT1,2.p2


Sorted Z-values histogram for motif ONECUT1,2.p2

Sorted Z-values for motif ONECUT1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ONECUT1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_29171729 5.799 NM_000371
TTR
transthyretin
chr6_+_30130982 5.620 NM_033229
TRIM15
tripartite motif containing 15
chr7_+_151653463 5.496 NM_145292
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr1_+_159557615 5.306 NM_001639
APCS
amyloid P component, serum
chr4_-_155511838 4.778 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr4_-_69536314 4.751 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr4_+_156824846 4.683 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr7_-_100239136 4.667 NM_003227
TFR2
transferrin receptor 2
chr2_+_135596185 4.193 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr10_+_7745325 4.041 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_+_63137260 4.015 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr1_+_63063186 3.957 NM_014495
ANGPTL3
angiopoietin-like 3
chr10_+_7745341 3.923 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 3.855 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745229 3.829 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745354 3.758 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_170744767 3.756 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_-_67594219 3.504 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr14_+_100789674 2.997 NM_207117
SLC25A47
solute carrier family 25, member 47
chr1_+_196946666 2.973 NM_030787
CFHR5
complement factor H-related 5
chr10_-_98031154 2.716 NM_001114094
NM_013314
BLNK

B-cell linker

chr3_+_186383770 2.713 NM_000412
HRG
histidine-rich glycoprotein
chr14_+_88490893 2.700 LOC283587
uncharacterized LOC283587
chr4_+_22694547 2.683 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr4_+_69681709 2.556 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr13_-_46679143 2.546 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr4_+_175839508 2.526 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr17_+_28268622 2.424 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr9_+_35673852 2.361 NM_001216
CA9
carbonic anhydrase IX
chr4_+_187148624 2.355 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr5_-_156390206 2.283 NM_001146726
NM_138379
TIMD4

T-cell immunoglobulin and mucin domain containing 4

chr10_+_96698409 2.227 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr11_+_58710721 2.220 NM_001220496
NM_080661
GLYATL1

glycine-N-acyltransferase-like 1

chr19_-_48389514 2.201 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr10_-_101841593 2.187 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr11_+_63057371 2.175 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr1_-_76397975 2.137 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chrX_-_24690740 2.130 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr12_+_21168629 2.057 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr1_-_116383323 1.977 NM_001111061
NHLH2
nescient helix loop helix 2
chr10_+_95517565 1.973 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr9_-_104147261 1.948 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_-_69817478 1.929 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_-_116034932 1.925 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr1_-_116383692 1.912 NM_005599
NHLH2
nescient helix loop helix 2
chr6_+_31913852 1.892 CFB
complement factor B
chr18_+_72201799 1.872 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr3_-_108836908 1.868 NM_014429
MORC1
MORC family CW-type zinc finger 1
chr12_+_107078476 1.859 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr7_-_121944485 1.846 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr6_+_64286348 1.845 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr22_-_37098620 1.844 NM_006078
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chr16_+_56225301 1.828 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chrX_+_106171328 1.817 CLDN2
claudin 2
chr15_-_76352068 1.811 NRG4
neuregulin 4
chr20_-_1974701 1.784 NM_001190898
NM_001190899
NM_024411
PDYN


prodynorphin


chr2_-_163695239 1.758 NM_033272
NM_173162
KCNH7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr14_-_24047428 1.757 JPH4
junctophilin 4
chr8_-_15095791 1.752 NM_139167
SGCZ
sarcoglycan, zeta
chr8_+_104831415 1.741 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr14_-_24047993 1.703 NM_001146028
NM_032452
JPH4

junctophilin 4

chr6_-_50016363 1.662 NM_001037498
DEFB112
defensin, beta 112
chr3_-_148939784 1.630 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_-_21228189 1.569 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_+_96257765 1.556 NM_138800
TRIM43
tripartite motif containing 43
chr2_-_88427535 1.518 NM_001443
FABP1
fatty acid binding protein 1, liver
chr2_-_96150478 1.516 NM_001164464
TRIM43B
tripartite motif containing 43B
chrX_-_131573638 1.500 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr2_+_162272619 1.490 NM_006593
TBR1
T-box, brain, 1
chr2_-_219031646 1.484 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr17_+_72439187 1.478 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_-_21252786 1.460 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_-_69886112 1.444 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr7_-_104909442 1.444 NM_182691
SRPK2
SRSF protein kinase 2
chrX_+_49832214 1.440 NM_000084
CLCN5
chloride channel 5
chr8_+_39442086 1.438 NM_001190956
NM_014237
ADAM18

ADAM metallopeptidase domain 18

chr16_-_11367451 1.429 NM_021247
PRM3
protamine 3
chr17_-_64225496 1.423 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_187187342 1.415 F11
coagulation factor XI
chr7_-_99381703 1.403 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr7_+_128349111 1.399 FAM71F1
family with sequence similarity 71, member F1
chr12_-_70083055 1.397 NM_152439
BEST3
bestrophin 3
chr1_+_34326075 1.393 NM_145205
HMGB4
high mobility group box 4
chr10_+_101088794 1.379 NM_020348
CNNM1
cyclin M1
chr6_+_31895201 1.373 NM_000063
NM_001145903
C2

complement component 2

chr19_+_9296269 1.338 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr20_+_42984088 1.333 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_+_107288199 1.329 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr16_-_72033876 1.326 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr7_+_99425635 1.325 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr22_+_24105207 1.322 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr1_+_196743929 1.314 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr10_+_68685791 1.308 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr4_+_187187117 1.294 NM_000128
F11
coagulation factor XI
chr11_-_46408105 1.276 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr6_+_131571298 1.272 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr20_-_1974393 1.268 NM_001190900
PDYN
prodynorphin
chr9_-_104145800 1.268 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr9_-_123812535 1.260 NM_001735
C5
complement component 5
chr10_-_94003002 1.251 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr10_+_32856650 1.250 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr7_-_23509972 1.231 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr18_-_73139588 1.228 NM_001037331
C18orf62
chromosome 18 open reading frame 62
chr3_+_39509069 1.216 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr10_-_129691047 1.199


chr2_-_163695028 1.198 KCNH7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr4_-_69434215 1.190 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr10_+_134901408 1.179 NM_001083909
GPR123
G protein-coupled receptor 123
chrX_-_142804515 1.175 NM_001009615
SPANXN2
SPANX family, member N2
chr3_+_35721115 1.174 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr17_+_31318881 1.164 NM_173847
SPACA3
sperm acrosome associated 3
chr5_-_160279045 1.157 NM_025153
ATP10B
ATPase, class V, type 10B
chr8_+_32504250 1.155 NM_013959
NRG1
neuregulin 1
chr3_+_108541544 1.134 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr5_+_176516550 1.108 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr5_-_41071404 1.106 NM_173489
HEATR7B2
HEAT repeat family member 7B2
chrY_+_16634487 1.102 NM_001206850
NLGN4Y
neuroligin 4, Y-linked
chr1_+_110993748 1.099 NM_032414
PROK1
prokineticin 1
chr2_-_42991201 1.098 NM_148962
OXER1
oxoeicosanoid (OXE) receptor 1
chrX_+_30261847 1.089 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr15_+_72690653 1.087 NM_001080462
TMEM202
transmembrane protein 202
chr16_+_67381252 1.082 NM_001161575
LRRC36
leucine rich repeat containing 36
chr19_-_48389571 1.064 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr17_-_34195745 1.060 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr14_+_62462540 1.057 NM_031914
SYT16
synaptotagmin XVI
chr13_+_52436116 1.052 NM_031290
CCDC70
coiled-coil domain containing 70
chr3_+_63428752 1.051 NM_144642
SYNPR
synaptoporin
chr1_+_182419255 1.046 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr4_-_72669757 1.036 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr11_-_64727608 1.033 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr19_+_9361605 1.025 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr6_+_100054649 1.006 NM_021620
PRDM13
PR domain containing 13
chr7_+_94297448 1.006 PEG10
paternally expressed 10
chr11_+_113775517 1.005 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr12_-_13248581 0.997 NM_001206843
NM_001206845
NM_031289
NM_153823
GSG1



germ cell associated 1



chr11_+_125703210 0.996 NM_001144874
PATE4
prostate and testis expressed 4
chr2_-_2334887 0.985 NM_015025
MYT1L
myelin transcription factor 1-like
chrX_-_133792497 0.984 NM_021796
PLAC1
placenta-specific 1
chr4_+_37962055 0.979 NM_006607
PTTG2
pituitary tumor-transforming 2
chr4_-_72649734 0.979 NM_000583
GC
group-specific component (vitamin D binding protein)
chr2_+_79252825 0.976 NM_001008387
NM_198448
REG3G

regenerating islet-derived 3 gamma

chr12_-_7818467 0.974 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr11_+_22696381 0.963 GAS2
growth arrest-specific 2
chr16_+_21245015 0.949 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr12_-_81763127 0.944 NM_001220479
NM_001220480
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chrY_+_4924128 0.931 NM_032972
NM_032973
PCDH11X
PCDH11Y

protocadherin 11 X-linked
protocadherin 11 Y-linked

chr3_+_169539709 0.930 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr8_+_76452202 0.926 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr7_+_86273219 0.925 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr7_-_55930444 0.923 NM_207366
SEPT14
septin 14
chr1_+_196788860 0.922 NM_002113
CFHR1
complement factor H-related 1
chr9_-_113100076 0.921 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr6_+_52935770 0.918 NM_012347
FBXO9
F-box protein 9
chr2_-_2335080 0.912 MYT1L
myelin transcription factor 1-like
chr19_-_48495339 0.912 NM_001128326
BSPH1
binder of sperm protein homolog 1
chrX_+_30248552 0.905 NM_002365
MAGEB3
melanoma antigen family B, 3
chr7_-_105319608 0.894 NM_138495
ATXN7L1
ataxin 7-like 1
chr1_-_197036350 0.894 NM_001994
F13B
coagulation factor XIII, B polypeptide
chrX_-_43832920 0.887 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_+_50571963 0.887 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_+_60467046 0.886 NM_031457
MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr10_-_50342052 0.883 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr1_-_153123426 0.874 NM_001014291
SPRR2G
small proline-rich protein 2G
chr11_+_22696318 0.873 NM_005256
GAS2
growth arrest-specific 2
chr2_+_158851690 0.870 NM_001135098
UPP2
uridine phosphorylase 2
chr7_-_18067445 0.866 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr3_+_108855560 0.861 FLJ22763
uncharacterized LOC401081
chr10_+_102732285 0.860 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chrY_+_2803111 0.858 NM_001145276
ZFY
zinc finger protein, Y-linked
chr6_-_49712055 0.857 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr3_-_126277757 0.852 NM_152533
C3orf22
chromosome 3 open reading frame 22
chr12_+_32654976 0.850 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr20_+_42984338 0.848 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr3_-_164914448 0.836 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr19_-_55458864 0.835 NM_001127255
NM_139176
NM_206828
NLRP7


NLR family, pyrin domain containing 7


chr2_+_234600320 0.831 NM_205862
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_-_51887740 0.830 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr14_+_58894709 0.826 NM_014749
KIAA0586
KIAA0586
chr6_-_135271206 0.821 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr3_+_111758464 0.819 NM_001042575
TMPRSS7
transmembrane protease, serine 7
chr18_-_3874252 0.817 NM_001242764
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chrX_-_75004979 0.814 NM_138703
MAGEE2
melanoma antigen family E, 2
chr6_-_119031230 0.812 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr1_+_145883867 0.809 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr15_-_60919642 0.808 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr6_+_105404922 0.804 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr7_+_123565908 0.803 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr19_+_7562444 0.798 NM_198534
C19orf45
chromosome 19 open reading frame 45
chr1_-_200377488 0.797 ZNF281
zinc finger protein 281
chr8_-_117023 0.792 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr14_-_24047774 0.790 JPH4
junctophilin 4
chr3_-_197300193 0.782 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr3_-_170744458 0.770 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr14_-_21029089 0.769 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr3_+_35683848 0.768 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chrX_+_85517970 0.765 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr12_+_10103914 0.760 NM_001207010
CLEC12A
C-type lectin domain family 12, member A
chr12_+_41831484 0.751 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr8_+_67039130 0.745 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr5_+_304290 0.744 NM_001242412
NM_020731
AHRR

aryl-hydrocarbon receptor repressor


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
17.95 5.95e-05 GO:0072376 protein activation cascade
52.13 3.82e-04 GO:0051917 regulation of fibrinolysis
117.28 5.16e-04 GO:0031639 plasminogen activation
20.06 2.39e-03 GO:0030193 regulation of blood coagulation
18.62 3.48e-03 GO:0050818 regulation of coagulation
16.30 6.80e-03 GO:0061041 regulation of wound healing
52.13 1.06e-02 GO:0031638 zymogen activation
22.35 1.46e-02 GO:0030195 negative regulation of blood coagulation
21.58 1.69e-02 GO:0050819 negative regulation of coagulation
36.09 3.54e-02 GO:0006957 complement activation, alternative pathway
5.72 4.11e-02 GO:0008202 steroid metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.16 8.07e-03 GO:0005615 extracellular space
5.35 1.36e-02 GO:0005792 microsome
2.14 1.37e-02 GO:0005576 extracellular region
5.18 1.71e-02 GO:0042598 vesicular fraction
1.48 3.69e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
22.35 4.08e-03 GO:0015020 glucuronosyltransferase activity
14.22 2.50e-02 GO:0043498 cell surface binding
78.19 3.43e-02 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
78.19 3.43e-02 GO:0034875 caffeine oxidase activity