Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 1.996


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ARNT2hg19_v1_chr15_+_80733579_807336310.551.0e-03Click!
AHRhg19_v1_chr7_+_17338182_17338357-0.271.3e-01Click!
ARNThg19_v1_chr1_-_150849062_1508491100.058.1e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_104178900 6.660 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr10_-_104178569 5.540 PSD
pleckstrin and Sec7 domain containing
chr22_+_42372763 5.339 NM_019106
NM_145733
SEPT3

septin 3

chr10_+_105344714 4.931 NEURL
neuralized homolog (Drosophila)
chr9_-_34589679 4.043 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr6_+_73331808 3.819 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr6_-_6007632 3.606 NM_016588
NRN1
neuritin 1
chr19_-_18314731 3.530 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr9_-_34590137 3.460 NM_001207011
CNTFR
ciliary neurotrophic factor receptor
chrX_-_152939256 3.236 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr7_+_128470462 3.137 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr2_+_220283098 3.092 NM_001927
DES
desmin
chr5_-_172755418 3.067 STC2
stanniocalcin 2
chr3_-_184870727 3.021 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr16_+_6069094 2.942 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr5_-_172755195 2.939 STC2
stanniocalcin 2
chr17_+_43971868 2.876 MAPT
microtubule-associated protein tau
chr17_+_43972014 2.838 MAPT
microtubule-associated protein tau
chr13_+_21277481 2.734 NM_138284
IL17D
interleukin 17D
chr17_+_43971655 2.731 NM_001123066
NM_001123067
NM_001203251
NM_001203252
NM_005910
NM_016834
NM_016835
NM_016841
MAPT







microtubule-associated protein tau







chr13_-_36705432 2.668 DCLK1
doublecortin-like kinase 1
chr15_-_79382839 2.634 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr1_-_13840157 2.547 NM_001010847
LRRC38
leucine rich repeat containing 38
chrX_+_38420690 2.483 NM_004615
TSPAN7
tetraspanin 7
chr15_+_84116172 2.482 SH3GL3
SH3-domain GRB2-like 3
chr6_-_127840499 2.441 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr15_-_79383080 2.405 NM_001145648
NM_002891
RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr6_+_73331570 2.389 NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842
KCNQ5




potassium voltage-gated channel, KQT-like subfamily, member 5




chr12_-_16758839 2.304 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_19006868 2.281 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr6_+_73331992 2.258 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr19_-_47164289 2.190 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr5_-_134369571 2.139 PITX1
paired-like homeodomain 1
chr10_+_60936346 2.118 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr12_+_54943358 2.100 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr2_+_220299699 2.076 NM_005876
SPEG
SPEG complex locus
chr8_+_85095501 2.013 NM_173848
RALYL
RALY RNA binding protein-like
chr22_-_19511777 2.001 CLDN5
claudin 5
chr13_+_51796363 1.965 NM_001242312
NM_145019
FAM124A

family with sequence similarity 124A

chr9_+_87283453 1.949 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr3_+_35681008 1.938 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr1_+_86046434 1.922 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr9_+_87284733 1.912 NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr15_+_84115979 1.910 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr4_-_168155732 1.883 NM_001040159
NM_001204352
NM_001204354
NM_001204355
NM_001204356
NM_001204358
NM_001251967
NM_016950
SPOCK3







sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3







chr10_+_105253734 1.840 NM_004210
NEURL
neuralized homolog (Drosophila)
chr11_+_112832089 1.817 NCAM1
neural cell adhesion molecule 1
chr9_+_87284625 1.785 NM_001007097
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr3_-_149688886 1.776 PFN2
profilin 2
chr17_-_8059637 1.768 PER1
period homolog 1 (Drosophila)
chr1_+_201252579 1.768 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr10_-_60936189 1.751


chr11_+_112831968 1.747 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr13_-_36705513 1.735 NM_004734
DCLK1
doublecortin-like kinase 1
chr7_-_44365019 1.731 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr4_-_168155576 1.729 NM_001204353
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr3_-_149688638 1.726 NM_002628
NM_053024
PFN2

profilin 2

chr5_-_134914447 1.724 CXCL14
chemokine (C-X-C motif) ligand 14
chr17_-_40333190 1.706 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr12_-_16759430 1.694 LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_6902797 1.678 NM_000844
NM_181874
GRM7

glutamate receptor, metabotropic 7

chr3_+_134514044 1.668 NM_004441
EPHB1
EPH receptor B1
chr3_-_151987332 1.666 LOC401093
uncharacterized LOC401093
chrX_-_152938742 1.663 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chrX_-_128788913 1.663 NM_017413
APLN
apelin
chr8_+_85095452 1.653 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr17_-_74236272 1.649 NM_052916
RNF157
ring finger protein 157
chr17_+_4487833 1.628 NM_001114974
SMTNL2
smoothelin-like 2
chr19_-_11565612 1.624


chr17_+_43971998 1.614 MAPT
microtubule-associated protein tau
chr12_+_103351451 1.602 NM_004316
ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr4_-_168155691 1.600 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr12_-_16759420 1.593 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_45236521 1.563 NM_016932
SIX2
SIX homeobox 2
chr13_-_36705466 1.561 DCLK1
doublecortin-like kinase 1
chr16_+_22825806 1.557 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr17_+_41177247 1.553 NM_005440
RND2
Rho family GTPase 2
chr11_+_112832201 1.550 NCAM1
neural cell adhesion molecule 1
chr3_-_184870627 1.547 C3orf70
chromosome 3 open reading frame 70
chr1_+_110693131 1.543 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr1_-_38512446 1.540 NM_002699
POU3F1
POU class 3 homeobox 1
chr11_+_112832281 1.538 NCAM1
neural cell adhesion molecule 1
chr14_+_33408458 1.532 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr5_+_151151511 1.529 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr4_+_94750041 1.513 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr3_+_134514300 1.492 EPHB1
EPH receptor B1
chr3_+_10857867 1.490 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr10_+_23983674 1.489 NM_001098500
KIAA1217
KIAA1217
chr6_-_40555111 1.489 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chrX_+_21392396 1.449 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr4_+_81118639 1.437 NM_001099403
PRDM8
PR domain containing 8
chr7_+_113726364 1.430 FOXP2
forkhead box P2
chrX_-_128977291 1.413 NM_001008222
ZDHHC9
zinc finger, DHHC-type containing 9
chr6_+_126070724 1.391 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr2_+_171673071 1.388 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr8_-_26371387 1.378 NM_007257
PNMA2
paraneoplastic antigen MA2
chr20_-_50384899 1.370 NM_006045
ATP9A
ATPase, class II, type 9A
chr20_-_50384861 1.365 ATP9A
ATPase, class II, type 9A
chr1_+_77748286 1.346 NM_012093
AK5
adenylate kinase 5
chr22_-_39548448 1.345 NM_175709
CBX7
chromobox homolog 7
chr11_+_17757494 1.345 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr1_+_109642814 1.341 SCARNA2
small Cajal body-specific RNA 2
chr10_+_26505593 1.339 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr20_-_3154169 1.337 ProSAPiP1
ProSAPiP1 protein
chr8_+_85095702 1.330 RALYL
RALY RNA binding protein-like
chr21_-_40032563 1.330 NM_001243428
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr19_-_38747171 1.327 NM_001243947
NM_033256
PPP1R14A

protein phosphatase 1, regulatory (inhibitor) subunit 14A

chr20_+_34680569 1.306 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_+_126070813 1.294 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr18_-_35145603 1.294 CELF4
CUGBP, Elav-like family member 4
chr17_+_7554711 1.292 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr5_+_42423811 1.276 NM_000163
GHR
growth hormone receptor
chr12_+_54943176 1.276 NM_000924
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr7_+_54610018 1.258 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr11_-_35440514 1.229 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_-_105412466 1.214 NM_025212
CXXC4
CXXC finger protein 4
chr12_-_88974094 1.206 NM_000899
NM_003994
KITLG

KIT ligand

chr3_-_160822625 1.203 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr3_+_6902812 1.202 GRM7
glutamate receptor, metabotropic 7
chr14_-_35183722 1.194 NM_001243645
NM_138638
CFL2

cofilin 2 (muscle)

chr9_-_101470836 1.193 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr22_-_19512001 1.189 CLDN5
claudin 5
chr3_-_62359189 1.184 NM_018008
FEZF2
FEZ family zinc finger 2
chr14_-_94254765 1.183 NM_178013
PRIMA1
proline rich membrane anchor 1
chr10_-_105452878 1.170 SH3PXD2A
SH3 and PX domains 2A
chr1_+_150336989 1.167 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr1_+_77747727 1.166 AK5
adenylate kinase 5
chrX_+_152954965 1.160 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr1_-_205649616 1.159 NM_033102
SLC45A3
solute carrier family 45, member 3
chr5_-_172756505 1.147 NM_003714
STC2
stanniocalcin 2
chr5_+_151151483 1.146 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr10_+_60936508 1.140 PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr2_+_206547131 1.136 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr16_+_22825481 1.135 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_24267672 1.127 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr16_-_86542463 1.125 LOC400550
uncharacterized LOC400550
chr21_+_47744032 1.121 NM_006031
PCNT
pericentrin
chr8_+_120885899 1.120 NM_022783
DEPTOR
DEP domain containing MTOR-interacting protein
chr4_-_5894695 1.116 NM_001014809
CRMP1
collapsin response mediator protein 1
chr1_+_145472454 1.115 ANKRD34A
ankyrin repeat domain 34A
chr19_-_38746978 1.115 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr13_-_84456473 1.102 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr7_+_97361270 1.099 NM_003182
NM_013996
NM_013997
NM_013998
TAC1



tachykinin, precursor 1



chr7_+_98246595 1.096 NM_002523
NPTX2
neuronal pentraxin II
chr9_+_140033588 1.095 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr4_-_154710207 1.089 NM_003013
SFRP2
secreted frizzled-related protein 2
chr1_+_218519576 1.083 TGFB2
transforming growth factor, beta 2
chr9_-_140196702 1.079 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr17_+_72427535 1.075 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr12_-_22487566 1.065 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr14_-_81687574 1.061 NM_201595
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chrX_-_140271275 1.058 LDOC1
leucine zipper, down-regulated in cancer 1
chr15_-_41166336 1.056 NM_133639
RHOV
ras homolog gene family, member V
chr1_-_37499708 1.052 NM_000831
GRIK3
glutamate receptor, ionotropic, kainate 3
chr13_-_40177304 1.040 LHFP
lipoma HMGIC fusion partner
chr2_-_119916338 1.039 NM_182528
C1QL2
complement component 1, q subcomponent-like 2
chr11_+_107462073 1.035 ELMOD1
ELMO/CED-12 domain containing 1
chr11_+_107461807 1.035 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr11_-_1593149 1.034 NM_004420
DUSP8
dual specificity phosphatase 8
chr11_+_107461955 1.032 ELMOD1
ELMO/CED-12 domain containing 1
chr17_-_38256905 1.031 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr16_+_67197287 1.026 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr16_-_70713927 1.021 MTSS1L
metastasis suppressor 1-like
chr13_-_44361032 1.021 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr9_-_35689902 1.018 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chrX_-_128977719 1.017 NM_016032
ZDHHC9
zinc finger, DHHC-type containing 9
chr9_+_71939487 1.016 NM_001127608
FAM189A2
family with sequence similarity 189, member A2
chr15_-_63673918 1.013 CA12
carbonic anhydrase XII
chr11_-_17498322 1.010 ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr1_+_41249479 1.010 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr1_+_77747602 1.007 NM_174858
AK5
adenylate kinase 5
chr6_+_24126349 1.002 NM_080723
NRSN1
neurensin 1
chr9_+_103115342 1.000


chr3_-_49449400 0.999 RHOA
ras homolog gene family, member A
chrX_+_130192215 0.999 NM_144967
ARHGAP36
Rho GTPase activating protein 36
chr14_-_61115906 0.999 NM_005982
SIX1
SIX homeobox 1
chr20_+_56964289 0.996 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr11_-_18813127 0.994 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr9_-_79520878 0.985 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr8_-_80679897 0.984 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr17_+_45772629 0.983 NM_014726
TBKBP1
TBK1 binding protein 1
chr17_-_38256548 0.978 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr5_-_176057324 0.978 NM_001001502
NM_003085
SNCB

synuclein, beta

chr7_+_86274076 0.970 GRM3
glutamate receptor, metabotropic 3
chr1_-_205649537 0.969 SLC45A3
solute carrier family 45, member 3
chr3_+_39851028 0.968 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr1_+_227127959 0.967 ADCK3
aarF domain containing kinase 3
chr4_+_20255234 0.964 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr16_-_77468930 0.962 NM_199355
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr2_+_29338207 0.960 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr2_+_153191830 0.953 FMNL2
formin-like 2
chr11_-_86383355 0.953 NM_006680
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr18_-_35145999 0.951 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr10_+_71211215 0.947 NM_012339
TSPAN15
tetraspanin 15
chr16_+_82660641 0.946 CDH13
cadherin 13, H-cadherin (heart)
chr6_-_146056372 0.940 EPM2A
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr8_+_68864589 0.939 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr6_-_105584982 0.936 NM_001199563
BVES
blood vessel epicardial substance
chr6_-_146056654 0.926 EPM2A
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr1_-_17445865 0.925 NM_007365
PADI2
peptidyl arginine deiminase, type II

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.76 1.37e-06 GO:0019226 transmission of nerve impulse
5.76 1.37e-06 GO:0035637 multicellular organismal signaling
6.11 1.68e-06 GO:0007268 synaptic transmission
4.39 6.96e-06 GO:0007267 cell-cell signaling
3.63 4.42e-05 GO:0007154 cell communication
1.76 5.62e-04 GO:0032501 multicellular organismal process
2.82 7.65e-04 GO:0007399 nervous system development
1.93 2.11e-03 GO:0023052 signaling
2.03 1.04e-02 GO:0048731 system development
3.12 1.15e-02 GO:0048468 cell development
1.93 1.85e-02 GO:0048856 anatomical structure development
1.86 2.49e-02 GO:0007275 multicellular organismal development
42.94 2.64e-02 GO:0006105 succinate metabolic process
143.12 3.33e-02 GO:0006540 glutamate decarboxylation to succinate
3.95 3.68e-02 GO:0009628 response to abiotic stimulus
2.32 3.72e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.17 6.60e-05 GO:0045202 synapse
4.87 3.40e-04 GO:0043005 neuron projection
5.47 6.85e-04 GO:0044456 synapse part
53.67 2.26e-03 GO:0061200 clathrin sculpted gamma-aminobutyric acid transport vesicle
53.67 2.26e-03 GO:0061202 clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
4.61 8.06e-03 GO:0044433 cytoplasmic vesicle part
35.79 8.69e-03 GO:0060198 clathrin sculpted vesicle
5.00 1.02e-02 GO:0030659 cytoplasmic vesicle membrane
4.83 1.33e-02 GO:0012506 vesicle membrane
1.68 1.43e-02 GO:0005886 plasma membrane
1.66 2.04e-02 GO:0071944 cell periphery
5.90 2.36e-02 GO:0043025 neuronal cell body
5.73 2.83e-02 GO:0044297 cell body
5.70 2.93e-02 GO:0030424 axon
1.97 3.70e-02 GO:0044459 plasma membrane part
8.43 3.99e-02 GO:0030665 clathrin coated vesicle membrane
8.23 4.44e-02 GO:0008021 synaptic vesicle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
20.45 7.04e-03 GO:0008066 glutamate receptor activity