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Illumina Body Map 2, young vs old
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Results for T
Z-value: 0.53
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Transcription factors associated with T
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| T | hg19_v2_chr6_-_166581333_166581365 | 0.26 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of T
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.9 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.6 | 3.6 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.5 | 3.5 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.2 | 3.4 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.0 | 3.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 2.9 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 0.2 | 2.6 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.2 | 2.2 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.3 | 2.1 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.0 | 2.1 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 3.2 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 3.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 2.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 1.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 1.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.2 | 1.2 | GO:0070876 | SOSS complex(GO:0070876) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 4.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.5 | 3.6 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.5 | 3.5 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.2 | 3.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 3.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 2.9 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.0 | 2.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.3 | 2.1 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.1 | 2.1 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 6.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 6.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 2.1 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 1.8 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 1.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 2.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.1 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 1.8 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.4 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 1.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |