ISMARA results: ZSCAN4

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Illumina Body Map 2, young vs old

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Results for ZSCAN4

Z-value: 0.95

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Transcription factors associated with ZSCAN4

Gene Symbol	Gene ID	Gene Info
ZSCAN4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000180532.6	zinc finger and SCAN domain containing 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZSCAN4	hg19_v2_chr19_+_58180303_58180303	-0.14	4.5e-01	Click!

Activity profile of ZSCAN4 motif

Sorted Z-values of ZSCAN4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_-_47613673 Show fit	2.93	ENST00000594486.1	AP001468.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Protein LOC101060037
chr3_+_111393501 Show fit	2.38	ENST00000393934.3	PLCXD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphatidylinositol-specific phospholipase C, X domain containing 2
chr3_+_111393659 Show fit	2.34	ENST00000477665.1	PLCXD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphatidylinositol-specific phospholipase C, X domain containing 2
chr1_+_233765353 Show fit	2.22	ENST00000366620.1	KCNK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium channel, subfamily K, member 1
chr16_-_86542652 Show fit	2.13	ENST00000599749.1	FENDRR Ensembl NCBI GeneCards UniProt NextProt Show fit	FOXF1 adjacent non-coding developmental regulatory RNA
chr9_-_93727673 Show fit	2.04	ENST00000427745.1	RP11-367F23.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-367F23.1
chrX_-_20134990 Show fit	1.97	ENST00000379651.3 ENST00000443379.3 ENST00000379643.5	MAP7D2 Ensembl NCBI GeneCards UniProt NextProt Show fit	MAP7 domain containing 2
chr17_+_63133587 Show fit	1.91	ENST00000449996.3 ENST00000262406.9	RGS9 Ensembl NCBI GeneCards UniProt NextProt Show fit	regulator of G-protein signaling 9
chr8_+_85095013 Show fit	1.87	ENST00000522613.1	RALYL Ensembl NCBI GeneCards UniProt NextProt Show fit	RALY RNA binding protein-like
chr17_+_9728828 Show fit	1.85	ENST00000262441.5	GLP2R Ensembl NCBI GeneCards UniProt NextProt Show fit	glucagon-like peptide 2 receptor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZSCAN4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	3.9	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3	3.6	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	3.6	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	3.2	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.2	2.2	GO:0060075	regulation of resting membrane potential(GO:0060075)
0.0	1.8	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.1	1.5	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.0	1.5	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.1	1.4	GO:0045218	zonula adherens maintenance(GO:0045218)

Showing 1 to 10 of 60 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.5	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	4.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	4.4	GO:0031225	anchored component of membrane(GO:0031225)
0.1	2.4	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	2.3	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.4	2.2	GO:1902937	inward rectifier potassium channel complex(GO:1902937)
0.1	1.5	GO:0045179	apical cortex(GO:0045179)
0.1	1.4	GO:0005915	zonula adherens(GO:0005915)
0.0	1.4	GO:0034707	chloride channel complex(GO:0034707)
0.1	1.3	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)

Showing 1 to 10 of 21 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.9	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.3	5.0	GO:0019864	IgG binding(GO:0019864)
0.0	4.0	GO:0008081	phosphoric diester hydrolase activity(GO:0008081)
0.0	3.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	2.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	2.2	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.5	1.8	GO:0004967	glucagon receptor activity(GO:0004967)
0.1	1.7	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0	1.6	GO:0016805	dipeptidase activity(GO:0016805)
0.1	1.5	GO:0043274	phospholipase binding(GO:0043274)

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	3.5	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.1	2.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	2.0	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	1.9	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	1.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	1.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	1.2	PID NOTCH PATHWAY	Notch signaling pathway
0.0	0.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	2.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	2.8	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	2.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	2.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	1.8	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.1	1.5	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	1.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	1.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells

Showing 1 to 10 of 17 entries

Results for ZSCAN4

Z-value: 0.95

Motif logo

Transcription factors associated with ZSCAN4

Activity-expression correlation:

Activity profile of ZSCAN4 motif

Sorted Z-values of ZSCAN4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZSCAN4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: